Page last updated: 2024-08-07 15:52:06
Lysosomal alpha-glucosidase
A lysosomal alpha-glucosidase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P10253]
Synonyms
EC 3.2.1.20;
Acid maltase;
Aglucosidase alfa
Research
Bioassay Publications (26)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (7.69) | 18.2507 |
| 2000's | 4 (15.38) | 29.6817 |
| 2010's | 18 (69.23) | 24.3611 |
| 2020's | 2 (7.69) | 2.80 |
Compounds (38)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
Drugs with Other Measurements
5-Journal of medicinal chemistry, , 02-10, Volume: 65, Issue:3, 2022
Inhibition of protein tyrosine phosphatase 1B (PTP1B) and α-glucosidase by xanthones from Cratoxylum cochinchinense, and their kinetic characterization.Bioorganic & medicinal chemistry, , 02-01, Volume: 26, Issue:3, 2018
[no title available]European journal of medicinal chemistry, , Feb-25, Volume: 146, 2018
Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation.Journal of medicinal chemistry, , Jan-28, Volume: 53, Issue:2, 2010
Synthesis and evaluation of D-gluco-pyranocyclopropyl amines as potential glucosidase inhibitors.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 19, Issue:23, 2009
In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures.Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008
Homoisofagomines: chemical-enzymatic synthesis and evaluation as alpha- and beta-glucosidase inhibitors.Bioorganic & medicinal chemistry letters, , Feb-22, Volume: 9, Issue:4, 1999
Phloroglucinol Benzophenones and Xanthones from the Leaves of Journal of natural products, , 01-24, Volume: 83, Issue:1, 2020
Synthesis of benzotriazoles derivatives and their dual potential as α-amylase and α-glucosidase inhibitors in vitro: Structure-activity relationship, molecular docking, and kinetic studies.European journal of medicinal chemistry, , Dec-01, Volume: 183, 2019
Role of sulphur-heterocycles in medicinal chemistry: An update.European journal of medicinal chemistry, , Oct-15, Volume: 180, 2019
Synthetic heterocyclic candidates as promising α-glucosidase inhibitors: An overview.European journal of medicinal chemistry, , Aug-15, Volume: 176, 2019
[no title available]European journal of medicinal chemistry, , Feb-25, Volume: 146, 2018
New butenolide derivatives from the marine sponge-derived fungus Aspergillus terreus.Bioorganic & medicinal chemistry letters, , 02-01, Volume: 28, Issue:3, 2018
Synthesis, α-glucosidase inhibition and molecular docking studies of novel thiazolidine-2,4-dione or rhodanine derivatives.MedChemComm, , Jul-01, Volume: 8, Issue:7, 2017
Bioactive Asarone-Derived Phenylpropanoids from the Rhizome of Acorus tatarinowii Schott.Journal of natural products, , 11-22, Volume: 80, Issue:11, 2017
Bioactive Azaphilone Derivatives from the Fungus Talaromyces aculeatus.Journal of natural products, , 08-25, Volume: 80, Issue:8, 2017
Synthesis, in vitro evaluation and molecular docking studies of novel triazine-triazole derivatives as potential α-glucosidase inhibitors.European journal of medicinal chemistry, , Jan-05, Volume: 125, 2017
5-Journal of medicinal chemistry, , 02-10, Volume: 65, Issue:3, 2022
N-Butyl-l-deoxynojirimycin (l-NBDNJ): Synthesis of an Allosteric Enhancer of α-Glucosidase Activity for the Treatment of Pompe Disease.Journal of medicinal chemistry, , 12-14, Volume: 60, Issue:23, 2017
Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation.Journal of medicinal chemistry, , Jan-28, Volume: 53, Issue:2, 2010
Synthesis and evaluation of D-gluco-pyranocyclopropyl amines as potential glucosidase inhibitors.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 19, Issue:23, 2009
5-Journal of medicinal chemistry, , 02-10, Volume: 65, Issue:3, 2022
Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation.Journal of medicinal chemistry, , Jan-28, Volume: 53, Issue:2, 2010
In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures.Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008
Polyketides with α-Glucosidase Inhibitory Activity from a Mangrove Endophytic Fungus, Penicillium sp. HN29-3B1.Journal of natural products, , Aug-28, Volume: 78, Issue:8, 2015
Synthesis, crystal structure and antidiabetic activity of substituted (E)-3-(Benzo [d]thiazol-2-ylamino) phenylprop-2-en-1-one.European journal of medicinal chemistry, , Volume: 59, 2013
In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures.Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008
Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation.Journal of medicinal chemistry, , Jan-28, Volume: 53, Issue:2, 2010
Synthesis and evaluation of D-gluco-pyranocyclopropyl amines as potential glucosidase inhibitors.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 19, Issue:23, 2009
Enables
This protein enables 4 target(s):
| Target | Category | Definition |
|---|
| alpha-1,4-glucosidase activity | molecular function | Catalysis of the hydrolysis of terminal, non-reducing alpha-(1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose. [EC:3.2.1.20] |
| carbohydrate binding | molecular function | Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. [GOC:mah] |
| maltose alpha-glucosidase activity | molecular function | Catalysis of the reaction: alpha-maltose + H2O = 2 alpha-D-glucose. [MetaCyc:RXN-2141] |
| alpha-glucosidase activity | molecular function | Catalysis of the hydrolysis of terminal, non-reducing alpha-linked alpha-D-glucose residue with release of alpha-D-glucose. [GOC:tb] |
Located In
This protein is located in 11 target(s):
| Target | Category | Definition |
|---|
| lysosome | cellular component | A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. [GOC:mah, ISBN:0198506732] |
| lysosomal membrane | cellular component | The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm. [GOC:ai] |
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| membrane | cellular component | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
| azurophil granule membrane | cellular component | The lipid bilayer surrounding an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid. [GOC:bf, PMID:17152095] |
| lysosomal lumen | cellular component | The volume enclosed within the lysosomal membrane. [GOC:jl, PMID:15213228] |
| intracellular membrane-bounded organelle | cellular component | Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. [GOC:go_curators] |
| extracellular exosome | cellular component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
| tertiary granule membrane | cellular component | The lipid bilayer surrounding a tertiary granule. [GOC:BHF, GOC:mah, GOC:rl, PMID:12070036] |
| ficolin-1-rich granule membrane | cellular component | The lipid bilayer surrounding a ficolin-1-rich granule. [GOC:mec, PMID:23650620] |
| autolysosome lumen | cellular component | The volume that is enclosed within the autolysosome single-membrane. [GOC:krc, GOC:nhn, PMID:17182262, PMID:24657946, PMID:26382870, PMID:32047650] |
Involved In
This protein is involved in 17 target(s):
| Target | Category | Definition |
|---|
| maltose metabolic process | biological process | The chemical reactions and pathways involving the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose), an intermediate in the catabolism of glycogen and starch. [GOC:jl, ISBN:0198506732] |
| regulation of the force of heart contraction | biological process | Any process that modulates the extent of heart contraction, changing the force with which blood is propelled. [GOC:dph, GOC:tb, PMID:10358008] |
| diaphragm contraction | biological process | A process in which force is generated within involuntary skeletal muscle tissue, resulting in a change in muscle geometry. This process occurs in the diaphragm. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The diaphragm is a striated muscle that is necessary for the process of respiratory gaseous exchange. [GOC:dph, GOC:mtg_muscle, PMID:12458206] |
| heart morphogenesis | biological process | The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. [GOC:dph, GOC:isa_complete] |
| glycogen catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. [ISBN:0198506732] |
| sucrose metabolic process | biological process | The chemical reactions and pathways involving sucrose, the disaccharide fructofuranosyl-glucopyranoside. [GOC:go_curators] |
| glucose metabolic process | biological process | The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. [ISBN:0198506732] |
| lysosome organization | biological process | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases. [GOC:mah] |
| locomotory behavior | biological process | The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions. [GOC:dph] |
| tissue development | biological process | The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure. [ISBN:0471245208] |
| aorta development | biological process | The progression of the aorta over time, from its initial formation to the mature structure. An aorta is an artery that carries blood from the heart to other parts of the body. [GOC:bf, GOC:dgh, MA:0000062, UBERON:0000947, Wikipedia:Aorta] |
| vacuolar sequestering | biological process | The process of transporting a substance into, and confining within, a vacuole. [GOC:jl] |
| muscle cell cellular homeostasis | biological process | The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state. [GOC:mah, PMID:3091429, PMID:7781901] |
| neuromuscular process controlling posture | biological process | Any process in which an organism voluntarily modulates its posture, the alignment of its anatomical parts. [GOC:dph, GOC:tb] |
| neuromuscular process controlling balance | biological process | Any process that an organism uses to control its balance, the orientation of the organism (or the head of the organism) in relation to the source of gravity. In humans and animals, balance is perceived through visual cues, the labyrinth system of the inner ears and information from skin pressure receptors and muscle and joint receptors. [GOC:ai, GOC:dph] |
| cardiac muscle contraction | biological process | Muscle contraction of cardiac muscle tissue. [GOC:dph] |
| glycophagy | biological process | The selective degradation of glycogen by macroautophagy. [GOC:autophagy, PMID:21893048] |