A kallikrein-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P06870]
EC 3.4.21.35;
Kidney/pancreas/salivary gland kallikrein;
Tissue kallikrein
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 4 (66.67) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| sivelestat | Homo sapiens (human) | IC50 | 2.0000 | 1 | 1 |
| sepimostate mesilate | Homo sapiens (human) | Ki | 0.6100 | 1 | 1 |
| foy 251 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| beta-naphthamidine | Homo sapiens (human) | Ki | 23.0000 | 1 | 1 |
| camostat mesylate | Homo sapiens (human) | IC50 | 34.1000 | 1 | 1 |
| dpc 423 | Homo sapiens (human) | Ki | 0.0610 | 1 | 1 |
| a-317567 | Homo sapiens (human) | Ki | 0.5760 | 1 | 1 |
This protein enables 1 target(s):
| Target | Category | Definition |
|---|---|---|
| serine-type endopeptidase activity | molecular function | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE] |
This protein is located in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| nucleus | cellular component | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators] |
| extracellular exosome | cellular component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| secretory granule | cellular component | A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules. [GOC:mah, ISBN:0198506732] |
This protein is involved in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| zymogen activation | biological process | The proteolytic processing of an inactive enzyme to an active form. [GOC:hjd] |
| regulation of systemic arterial blood pressure | biological process | The process that modulates the force with which blood travels through the systemic arterial circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure. [GOC:mtg_cardio] |