Proteins > Solute carrier organic anion transporter family member 1B1
Page last updated: 2024-08-07 18:54:17
Solute carrier organic anion transporter family member 1B1
A solute carrier organic anion transporter family member 1B1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y6L6]
Synonyms
Liver-specific organic anion transporter 1;
LST-1;
OATP-C;
Sodium-independent organic anion-transporting polypeptide 2;
OATP-2;
Solute carrier family 21 member 6
Research
Bioassay Publications (29)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (6.90) | 18.2507 |
| 2000's | 14 (48.28) | 29.6817 |
| 2010's | 11 (37.93) | 24.3611 |
| 2020's | 2 (6.90) | 2.80 |
Compounds (85)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| microcystin yr | Homo sapiens (human) | EC50 | 0.0045 | 1 | 1 |
Drugs with Other Measurements
Structure-based identification of OATP1B1/3 inhibitors.Molecular pharmacology, , Volume: 83, Issue:6, 2013
The development, characterization, and application of an OATP1B1 inhibition assay in drug discovery.Drug metabolism and disposition: the biological fate of chemicals, , Volume: 40, Issue:8, 2012
Characterization of the transport of the bicyclic peptide phalloidin by human hepatic transport proteins.Naunyn-Schmiedeberg's archives of pharmacology, , Volume: 368, Issue:5, 2003
Hepatic uptake of bilirubin and its conjugates by the human organic anion transporter SLC21A6.The Journal of biological chemistry, , Mar-30, Volume: 276, Issue:13, 2001
Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver.Gastroenterology, , Volume: 120, Issue:2, 2001
A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane.American journal of physiology. Gastrointestinal and liver physiology, , Volume: 278, Issue:1, 2000
Hepatic uptake of bilirubin and its conjugates by the human organic anion transporter SLC21A6.The Journal of biological chemistry, , Mar-30, Volume: 276, Issue:13, 2001
Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1.The Journal of biological chemistry, , Jun-11, Volume: 274, Issue:24, 1999
A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters.The Journal of biological chemistry, , Dec-24, Volume: 274, Issue:52, 1999
The development, characterization, and application of an OATP1B1 inhibition assay in drug discovery.Drug metabolism and disposition: the biological fate of chemicals, , Volume: 40, Issue:8, 2012
Differential interaction of 3-hydroxy-3-methylglutaryl-coa reductase inhibitors with ABCB1, ABCC2, and OATP1B1.Drug metabolism and disposition: the biological fate of chemicals, , Volume: 33, Issue:4, 2005
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.Journal of medicinal chemistry, , May-24, Volume: 55, Issue:10, 2012
Functional characterization of SLCO1B1 (OATP-C) variants, SLCO1B1*5, SLCO1B1*15 and SLCO1B1*15+C1007G, by using transient expression systems of HeLa and HEK293 cells.Pharmacogenetics and genomics, , Volume: 15, Issue:7, 2005
A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters.The Journal of biological chemistry, , Dec-24, Volume: 274, Issue:52, 1999
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.Journal of medicinal chemistry, , May-24, Volume: 55, Issue:10, 2012
The development, characterization, and application of an OATP1B1 inhibition assay in drug discovery.Drug metabolism and disposition: the biological fate of chemicals, , Volume: 40, Issue:8, 2012
Functional characterization of SLCO1B1 (OATP-C) variants, SLCO1B1*5, SLCO1B1*15 and SLCO1B1*15+C1007G, by using transient expression systems of HeLa and HEK293 cells.Pharmacogenetics and genomics, , Volume: 15, Issue:7, 2005
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.Journal of medicinal chemistry, , May-24, Volume: 55, Issue:10, 2012
The development, characterization, and application of an OATP1B1 inhibition assay in drug discovery.Drug metabolism and disposition: the biological fate of chemicals, , Volume: 40, Issue:8, 2012
Structure-based identification of OATP1B1/3 inhibitors.Molecular pharmacology, , Volume: 83, Issue:6, 2013
Role of organic anion-transporting polypeptides, OATP-A, OATP-C and OATP-8, in the human placenta-maternal liver tandem excretory pathway for foetal bilirubin.The Biochemical journal, , May-01, Volume: 371, Issue:Pt 3, 2003
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.Journal of medicinal chemistry, , May-24, Volume: 55, Issue:10, 2012
The development, characterization, and application of an OATP1B1 inhibition assay in drug discovery.Drug metabolism and disposition: the biological fate of chemicals, , Volume: 40, Issue:8, 2012
Functional characterization of human organic anion transporting polypeptide B (OATP-B) in comparison with liver-specific OATP-C.Pharmaceutical research, , Volume: 18, Issue:9, 2001
A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane.American journal of physiology. Gastrointestinal and liver physiology, , Volume: 278, Issue:1, 2000
[no title available]Journal of medicinal chemistry, , 01-14, Volume: 64, Issue:1, 2021
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.Journal of medicinal chemistry, , May-24, Volume: 55, Issue:10, 2012
The development, characterization, and application of an OATP1B1 inhibition assay in drug discovery.Drug metabolism and disposition: the biological fate of chemicals, , Volume: 40, Issue:8, 2012
Inhibition of transporter-mediated hepatic uptake as a mechanism for drug-drug interaction between cerivastatin and cyclosporin A.The Journal of pharmacology and experimental therapeutics, , Volume: 304, Issue:2, 2003
Characterization of the transport of the bicyclic peptide phalloidin by human hepatic transport proteins.Naunyn-Schmiedeberg's archives of pharmacology, , Volume: 368, Issue:5, 2003
Differential interaction of 3-hydroxy-3-methylglutaryl-coa reductase inhibitors with ABCB1, ABCC2, and OATP1B1.Drug metabolism and disposition: the biological fate of chemicals, , Volume: 33, Issue:4, 2005
Interactions of rifamycin SV and rifampicin with organic anion uptake systems of human liver.Hepatology (Baltimore, Md.), , Volume: 36, Issue:1, 2002
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.Journal of medicinal chemistry, , May-24, Volume: 55, Issue:10, 2012
The development, characterization, and application of an OATP1B1 inhibition assay in drug discovery.Drug metabolism and disposition: the biological fate of chemicals, , Volume: 40, Issue:8, 2012
Human organic anion transporting polypeptide-C (SLC21A6) is a major determinant of rifampin-mediated pregnane X receptor activation.The Journal of pharmacology and experimental therapeutics, , Volume: 304, Issue:1, 2003
Interactions of rifamycin SV and rifampicin with organic anion uptake systems of human liver.Hepatology (Baltimore, Md.), , Volume: 36, Issue:1, 2002
Enables
This protein enables 5 target(s):
| Target | Category | Definition |
|---|
| organic anion transmembrane transporter activity | molecular function | Enables the transfer of organic anions from one side of a membrane to the other. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage. [GOC:ai] |
| bile acid transmembrane transporter activity | molecular function | Enables the transfer of bile acid from one side of a membrane to the other. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine. [GOC:ai] |
| prostaglandin transmembrane transporter activity | molecular function | Enables the transfer of prostaglandins from one side of a membrane to the other. A prostaglandin is any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities. [GOC:ai] |
| sodium-independent organic anion transmembrane transporter activity | molecular function | Enables the transfer of organic anions from one side of a membrane to the other, in a sodium independent manner. [GOC:go_curators] |
| thyroid hormone transmembrane transporter activity | molecular function | Enables the transfer of thyroid hormones from one side of a membrane to the other. Thyroid hormone are any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine. [GOC:ai] |
Located In
This protein is located in 3 target(s):
| Target | Category | Definition |
|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| basal plasma membrane | cellular component | The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. [GOC:go_curators] |
| membrane | cellular component | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
Active In
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|
| basolateral plasma membrane | cellular component | The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. [GOC:go_curators] |
Involved In
This protein is involved in 9 target(s):
| Target | Category | Definition |
|---|
| xenobiotic metabolic process | biological process | The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:cab2, GOC:krc] |
| monoatomic ion transport | biological process | The directed movement of a monoatomic ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic ions (also called simple ions) are ions consisting of exactly one atom. [GOC:ai] |
| organic anion transport | biological process | The directed movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage. [GOC:ai, GOC:krc] |
| bile acid and bile salt transport | biological process | The directed movement of bile acid and bile salts into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:dph, GOC:krc, PMID:12663868, PMID:14699511] |
| prostaglandin transport | biological process | The directed movement of prostaglandins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc] |
| heme catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. [GOC:jl] |
| sodium-independent organic anion transport | biological process | The directed, sodium-independent, movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:go_curators] |
| transmembrane transport | biological process | The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. [GOC:dph, GOC:jid] |
| thyroid hormone transport | biological process | The directed movement of thyroid hormone into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:rph] |