Transient receptor potential cation channel subfamily A member 1

A transient receptor potential cation channel TRPA1 that is encoded in the genome of human. [PRO:HJD, UniProtKB:O75762]

Synonyms

Ankyrin-like with transmembrane domains protein 1;
Transformation-sensitive protein p120;
Wasabi receptor

Research

Bioassay Publications (25)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (12.00)	29.6817
2010's	19 (76.00)	24.3611
2020's	3 (12.00)	2.80

Compounds (85)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
cannabinol	Homo sapiens (human)	IC50	0.3050	2	2
cannabichromene	Homo sapiens (human)	IC50	0.3700	1	1
(6ar-trans)-isomer of tetrahydrocannabivarin 9	Homo sapiens (human)	IC50	1.9700	2	2
camphora	Homo sapiens (human)	IC50	530.0000	2	2
dihydroresveratrol	Homo sapiens (human)	IC50	30.0000	1	1
resveratrol	Homo sapiens (human)	IC50	15.3750	2	2
butylidenephthalide	Homo sapiens (human)	IC50	23.0000	1	1
hc 030031	Homo sapiens (human)	IC50	7.3319	11	12
tranilast	Homo sapiens (human)	IC50	125.9465	1	2
cannabigerol	Homo sapiens (human)	IC50	13.0000	1	1
borneol	Homo sapiens (human)	IC50	300.0000	1	1
4-(4-chlorophenyl)-3-methylbut-3-en-2-oxime	Homo sapiens (human)	IC50	3.2778	5	6
cannabidivarin	Homo sapiens (human)	IC50	1.3000	1	1
a-438079	Homo sapiens (human)	IC50	0.0590	2	0
a 967079	Homo sapiens (human)	IC50	0.0691	3	3

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
4-vinylguaiacol	Homo sapiens (human)	EC50	82.8000	1	1
3-methylcatechol	Homo sapiens (human)	EC50	2.8300	1	1
indole	Homo sapiens (human)	EC50	75.2000	1	1
menthol	Homo sapiens (human)	EC50	30.0076	2	3
benzyl isothiocyanate	Homo sapiens (human)	EC50	13.0921	6	6
cannabinol	Homo sapiens (human)	EC50	0.1800	1	1
diclofenac	Homo sapiens (human)	EC50	109.6986	2	3
disulfiram	Homo sapiens (human)	EC50	3.0000	1	1
flufenamic acid	Homo sapiens (human)	EC50	12.6394	2	3
iodoacetamide	Homo sapiens (human)	EC50	357.0000	1	1
juglone	Homo sapiens (human)	EC50	1.7000	1	1
mefenamic acid	Homo sapiens (human)	EC50	31.1986	2	3
masoprocol	Homo sapiens (human)	EC50	25.1271	2	3
5-nitro-2-(3-phenylpropylamino)benzoic acid	Homo sapiens (human)	EC50	0.5075	2	3
probenecid	Homo sapiens (human)	EC50	4,200.0000	1	1
allyl isothiocyanate	Homo sapiens (human)	EC50	7.7870	13	14
thymol	Homo sapiens (human)	EC50	43.0937	6	7
2-chlorophenol	Homo sapiens (human)	EC50	501.0000	1	1
benzyl bromide	Homo sapiens (human)	EC50	12.0000	1	1
ethyl bromoacetate	Homo sapiens (human)	EC50	0.0390	1	1
acrolein	Homo sapiens (human)	EC50	12.9431	4	5
dibenz(b,f)(1,4)oxazepine	Homo sapiens (human)	EC50	0.1029	2	3
4-methylcatechol	Homo sapiens (human)	EC50	11.7000	1	1
plumbagin	Homo sapiens (human)	EC50	0.4600	1	1
carvacrol	Homo sapiens (human)	EC50	13.5320	2	3
2,3-dimethylphenol	Homo sapiens (human)	EC50	86.0000	1	1
toluene 2,4-diisocyanate	Homo sapiens (human)	EC50	10.0000	1	1
allyl sulfide	Homo sapiens (human)	EC50	254.0000	1	1
bromoacetone	Homo sapiens (human)	EC50	1.1000	1	1
diallyl trisulfide	Homo sapiens (human)	EC50	0.4900	1	1
perillaldehyde	Homo sapiens (human)	EC50	41.0000	1	1
diallyl disulfide	Homo sapiens (human)	EC50	66.2750	2	2
menthol	Homo sapiens (human)	EC50	96.0000	1	1
phenethyl isothiocyanate	Homo sapiens (human)	EC50	5.1850	2	2
o-chlorobenzylidenemalonitrile	Homo sapiens (human)	EC50	0.0009	1	1
chlordantoin	Homo sapiens (human)	EC50	3.0000	1	1
cannabichromene	Homo sapiens (human)	EC50	0.0900	1	1
isovelleral	Homo sapiens (human)	EC50	0.5900	1	1
iberverin	Homo sapiens (human)	EC50	0.4500	1	1
4-ethylguaiacol	Homo sapiens (human)	EC50	101.0000	1	1
allicin	Homo sapiens (human)	EC50	1.9100	1	1
perilla ketone	Homo sapiens (human)	EC50	19.7000	1	1
4-ethylcatechol	Homo sapiens (human)	EC50	8.6900	1	1
polygodial	Homo sapiens (human)	EC50	0.0590	1	1
voacamine	Homo sapiens (human)	EC50	8.0000	2	2
erucin	Homo sapiens (human)	EC50	0.4200	1	1
nicotine	Homo sapiens (human)	EC50	152,369.0000	2	3
beta-eudesmol	Homo sapiens (human)	EC50	33.0000	1	1
(6ar-trans)-isomer of tetrahydrocannabivarin 9	Homo sapiens (human)	EC50	0.7850	2	2
4-hydroxybenzyl isothiocyanate	Homo sapiens (human)	EC50	20.0000	1	1
ag 3-5	Homo sapiens (human)	EC50	100.0000	1	1
6-methylthiohexyl isothiocyanate	Homo sapiens (human)	EC50	0.5800	1	1
dihydroresveratrol	Homo sapiens (human)	EC50	30.0000	1	1
resveratrol	Homo sapiens (human)	EC50	30.0000	1	1
2-butenal	Homo sapiens (human)	EC50	16.0000	1	1
cinnamaldehyde	Homo sapiens (human)	EC50	18.8823	4	5
isoeugenol	Homo sapiens (human)	EC50	149.0000	1	1
urb 597	Homo sapiens (human)	EC50	26,993.9200	4	5
prostaglandin a2	Homo sapiens (human)	EC50	24.0000	1	1
prostaglandin a1	Homo sapiens (human)	EC50	15.1000	1	1
15-deoxy-delta(12,14)-prostaglandin j2	Homo sapiens (human)	EC50	5.6000	1	1
cannabigerol	Homo sapiens (human)	EC50	0.7000	1	1
ligustilide	Homo sapiens (human)	EC50	44.0000	1	1
4-amylcinnamoylanthranilic acid	Homo sapiens (human)	EC50	28.0919	1	2
farnesylthioacetic acid	Homo sapiens (human)	EC50	90.0000	1	1
2-pentenal	Homo sapiens (human)	EC50	5.0000	2	2
catharanthine	Homo sapiens (human)	EC50	9.0000	1	1
s-trans,trans-farnesylthiosalicylic acid	Homo sapiens (human)	EC50	3.4079	3	4
4-oxo-2-nonenal	Homo sapiens (human)	EC50	1.9000	1	1
n-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2h)-carboxamide	Homo sapiens (human)	EC50	4.5000	1	1
arachidonoylserotonin	Homo sapiens (human)	EC50	25.0000	1	1
methylphenidate	Homo sapiens (human)	EC50	25.0000	1	1
cannabidivarin	Homo sapiens (human)	EC50	0.4200	1	1
8-iso-prostaglandin a2	Homo sapiens (human)	EC50	22.4000	1	1
voacristine	Homo sapiens (human)	EC50	30.0000	1	1
miogadial	Homo sapiens (human)	EC50	0.2000	1	1

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
allyl isothiocyanate	Homo sapiens (human)	Activity	10.0000	1	1
dronabinol	Homo sapiens (human)	Activity	10.0000	1	1
allicin	Homo sapiens (human)	Activity	10.0000	1	1
ag 3-5	Homo sapiens (human)	Activity	0.0990	1	1
cinnamaldehyde	Homo sapiens (human)	Activity	10.0000	1	1
4-(4-chlorophenyl)-3-methylbut-3-en-2-oxime	Homo sapiens (human)	pA2	1.2600	1	1

Enables

This protein enables 5 target(s):

Target	Category	Definition
calcium channel activity	molecular function	Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. [GOC:mtg_transport, GOC:pr, ISBN:0815340729]
channel activity	molecular function	Enables the energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules. [GOC:mtg_transport, ISBN:0815340729]
intracellularly gated calcium channel activity	molecular function	Enables the transmembrane transfer of a calcium ion by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts. [GOC:mah]
identical protein binding	molecular function	Binding to an identical protein or proteins. [GOC:jl]
temperature-gated cation channel activity	molecular function	Enables the transmembrane transfer of a cation by a channel that opens in response to a temperature stimulus (e.g. exposure to a temperature range different than the optimal temperature for that organism). [GOC:ha, GOC:pr, PMID:23027824]

Located In

This protein is located in 2 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
stereocilium bundle	cellular component	A bundle of cross-linked stereocilia, arranged around a kinocilium on the apical surface of a sensory hair cell (e.g. a neuromast, auditory or vestibular hair cell). Stereocilium bundles act as mechanosensory organelles by responding to fluid motion or fluid pressure changes. [GOC:ecd, PMID:15661519, PMID:7840137]

Involved In

This protein is involved in 17 target(s):

Target	Category	Definition
monoatomic ion transport	biological process	The directed movement of a monoatomic ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic ions (also called simple ions) are ions consisting of exactly one atom. [GOC:ai]
intracellular calcium ion homeostasis	biological process	A homeostatic process involved in the maintenance of a steady state level of calcium ions within a cell. [GOC:ceb, GOC:mah]
cell surface receptor signaling pathway	biological process	The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription. [GOC:signaling]
response to cold	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism. [GOC:lr]
response to xenobiotic stimulus	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:jl, GOC:krc]
response to organic substance	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus. [GOC:sm, PMID:23356676]
response to organic cyclic compound	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus. [GOC:ef]
sensory perception of pain	biological process	The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process. [GOC:curators]
calcium-mediated signaling	biological process	Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions. [GOC:signaling]
response to pain	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli. [GOC:jid, PMID:10203867, PMID:12723742, PMID:12843304, Wikipedia:Pain]
thermoception	biological process	The series of events required for an organism to receive a temperature stimulus, convert it to a molecular signal, and recognize and characterize the signal. Thermoception in larger animals is mainly done in the skin; mammals have at least two types of sensor, for detecting heat (temperatures above body temperature) and cold (temperatures below body temperature). [GOC:ai, Wikipedia:Thermoception]
detection of mechanical stimulus involved in sensory perception of pain	biological process	The series of events involved in the perception of pain in which a mechanical stimulus is received and converted into a molecular signal. [GOC:ai, GOC:dos]
detection of chemical stimulus involved in sensory perception of pain	biological process	The series of events involved in the perception of pain in which a chemical stimulus is received and converted into a molecular signal. [GOC:ai]
protein homotetramerization	biological process	The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits. [GOC:go_curators]
cellular response to hydrogen peroxide	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus. [CHEBI:16240, GOC:mah]
calcium ion transmembrane transport	biological process	A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. [GOC:mah]
cellular response to organic substance	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus. [GOC:mah]