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Androgen receptor
An androgen receptor that is encoded in the genome of mouse. [OMA:P19091, PRO:DNx]
Synonyms
Dihydrotestosterone receptor;
Nuclear receptor subfamily 3 group C member 4
Research
Bioassay Publications (11)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 5 (45.45) | 29.6817 |
| 2010's | 4 (36.36) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
Compounds (14)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| bicalutamide | Mus musculus (house mouse) | IC50 | 1.8350 | 2 | 2 |
| dihydrotestosterone | Mus musculus (house mouse) | IC50 | 0.0010 | 1 | 1 |
| hydroxyflutamide | Mus musculus (house mouse) | IC50 | 0.6073 | 3 | 3 |
| 17-n,n-diethylcarbamoyl-4-methyl-4-azaandrostane-3-one | Mus musculus (house mouse) | IC50 | 0.4630 | 1 | 1 |
| lg190155 | Mus musculus (house mouse) | IC50 | 1.9000 | 1 | 1 |
| lg190178 | Mus musculus (house mouse) | IC50 | 0.0190 | 1 | 1 |
| 5-(2,5-difluorophenyl)-N-(2,6-dimethylphenyl)-2-furancarboxamide | Mus musculus (house mouse) | IC50 | 25.0000 | 1 | 0 |
| 5-(2,5-dichlorophenyl)-N-(2,6-dimethoxyphenyl)-2-furancarboxamide | Mus musculus (house mouse) | IC50 | 10.5400 | 1 | 0 |
| 5-(2,5-dichlorophenyl)-N-[2,6-di(propan-2-yl)phenyl]-2-furancarboxamide | Mus musculus (house mouse) | IC50 | 25.0000 | 1 | 0 |
| 5-(2,5-dichlorophenyl)-N-(2,6-diethylphenyl)-2-furancarboxamide | Mus musculus (house mouse) | IC50 | 25.0000 | 1 | 0 |
| N-(2,6-dimethylphenyl)-5-(4-methyl-3-thiophenyl)-2-furancarboxamide | Mus musculus (house mouse) | IC50 | 25.0000 | 1 | 0 |
Drugs with Activation Measurements
Development of silicon-containing bis-phenol derivatives as androgen receptor antagonists: selectivity switching by C/Si exchange.Bioorganic & medicinal chemistry, , Apr-01, Volume: 21, Issue:7, 2013
Novel selective anti-androgens with a diphenylpentane skeleton.Bioorganic & medicinal chemistry letters, , Nov-15, Volume: 20, Issue:22, 2010
Novel 6-aryl-1,4-dihydrobenzo[d]oxazine-2-thiones as potent, selective, and orally active nonsteroidal progesterone receptor agonists.Bioorganic & medicinal chemistry letters, , Apr-07, Volume: 13, Issue:7, 2003
Novel 5-aryl-1,3-dihydro-indole-2-thiones. potent, orally active progesterone receptor agonists.Bioorganic & medicinal chemistry letters, , Apr-07, Volume: 13, Issue:7, 2003
SAR based design of nicotinamides as a novel class of androgen receptor antagonists for prostate cancer.Journal of medicinal chemistry, , Apr-25, Volume: 56, Issue:8, 2013
Synthesis, structure-activity relationships, and characterization of novel nonsteroidal and selective androgen receptor modulators.Journal of medicinal chemistry, , Nov-26, Volume: 52, Issue:22, 2009
Design and Synthesis of 4-(4-Benzoylaminophenoxy)phenol Derivatives As Androgen Receptor Antagonists.ACS medicinal chemistry letters, , Oct-10, Volume: 4, Issue:10, 2013
Development of silicon-containing bis-phenol derivatives as androgen receptor antagonists: selectivity switching by C/Si exchange.Bioorganic & medicinal chemistry, , Apr-01, Volume: 21, Issue:7, 2013
Synthesis and in vitro activity of 17 beta-(N-alkyl/arylformamido)- and 17 beta-[(N-alkyl/aryl)alkyl/arylamido]-4-methyl-4-aza-3-oxo-5 alpha-androstan-3-ones as inhibitors of human 5 alpha-reductases and antagonists of the androgen receptor.Journal of medicinal chemistry, , Mar-31, Volume: 38, Issue:7, 1995
Therapeutic Strategies to Target the Androgen Receptor.Journal of medicinal chemistry, , 07-14, Volume: 65, Issue:13, 2022
Synthesis and SAR of tetrahydropyrrolo[1,2-b][1,2,5]thiadiazol-2(3H)-one 1,1-dioxide analogues as highly potent selective androgen receptor modulators.Bioorganic & medicinal chemistry letters, , Aug-15, Volume: 17, Issue:16, 2007