A nischarin that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y2I1]
Imidazoline receptor 1;
I-1;
IR1;
Imidazoline receptor antisera-selected protein;
hIRAS;
Imidazoline-1 receptor;
I1R;
Imidazoline-1 receptor candidate protein;
I-1 receptor candidate protein;
I1R candidate protein
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (30.77) | 18.2507 |
| 2000's | 7 (53.85) | 29.6817 |
| 2010's | 1 (7.69) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| cirazoline | Homo sapiens (human) | Ki | 0.0990 | 1 | 2 |
| clonidine | Homo sapiens (human) | Ki | 0.0322 | 3 | 4 |
| guanfacine | Homo sapiens (human) | Ki | 0.0190 | 1 | 1 |
| naphazoline | Homo sapiens (human) | Ki | 0.1216 | 1 | 2 |
| ondansetron | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| oxymetazoline | Homo sapiens (human) | Ki | 0.0062 | 1 | 2 |
| 4-iodoclonidine | Homo sapiens (human) | Ki | 0.0048 | 1 | 2 |
| moxonidine | Homo sapiens (human) | Ki | 0.0301 | 2 | 2 |
| tizanidine | Homo sapiens (human) | Ki | 0.0283 | 1 | 2 |
| phentolamine | Homo sapiens (human) | Ki | 0.0114 | 1 | 1 |
| idazoxan | Homo sapiens (human) | Ki | 0.9370 | 2 | 3 |
| rilmenidine | Homo sapiens (human) | Ki | 0.0642 | 2 | 3 |
| efaroxan | Homo sapiens (human) | Ki | 0.0591 | 2 | 3 |
| tryptoline | Homo sapiens (human) | Ki | 0.1800 | 1 | 1 |
| 293b cpd | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| 4-chloro-2-(2-imidazolin-2-ylamino)isoindoline | Homo sapiens (human) | Ki | 0.2319 | 1 | 2 |
| harmalan | Homo sapiens (human) | Ki | 0.0970 | 2 | 2 |
| n(1)-guanyl-1,7-diaminoheptane | Homo sapiens (human) | IC50 | 0.5000 | 1 | 1 |
| 2-(2-benzofuranyl)-2-imidazoline | Homo sapiens (human) | IC50 | 6.4000 | 1 | 1 |
| 2-(2-benzofuranyl)-2-imidazoline | Homo sapiens (human) | Ki | 0.0700 | 1 | 1 |
| harmine | Homo sapiens (human) | Ki | 6.9110 | 2 | 2 |
| guanabenz | Homo sapiens (human) | Ki | 0.0347 | 1 | 2 |
| tracizoline | Homo sapiens (human) | Ki | 0.9625 | 4 | 4 |
| 6-cyano-4-(n-ethylsulfonyl-n-methylamino)-3-hydroxy-2,2-dimethylchromane, (trans-(+))-isomer | Homo sapiens (human) | IC50 | 39.0000 | 1 | 1 |
| cilansetron | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| 4-n-butyl-1-(4-(2-methylphenyl)-4-oxo-1-butyl)-piperidine hydrogen chloride | Homo sapiens (human) | Ki | 1.0000 | 1 | 1 |
| bix 02565 | Homo sapiens (human) | IC50 | 0.0970 | 1 | 0 |
This protein enables 6 target(s):
| Target | Category | Definition |
|---|---|---|
| integrin binding | molecular function | Binding to an integrin. [GOC:ceb] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| phosphatidylinositol binding | molecular function | Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives. [GOC:bf, ISBN:0198506732, PMID:11395417] |
| identical protein binding | molecular function | Binding to an identical protein or proteins. [GOC:jl] |
| dynein heavy chain binding | molecular function | Binding to a heavy chain of the dynein complex. [GOC:bf] |
| alpha-tubulin binding | molecular function | Binding to the microtubule constituent protein alpha-tubulin. [GOC:jl] |
This protein is located in 9 target(s):
| Target | Category | Definition |
|---|---|---|
| nucleoplasm | cellular component | That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653] |
| early endosome | cellular component | A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways. [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| microtubule cytoskeleton | cellular component | The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins. [GOC:jl, ISBN:0395825172] |
| membrane | cellular component | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
| intracellular membrane-bounded organelle | cellular component | Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. [GOC:go_curators] |
| intercellular bridge | cellular component | A direct connection between the cytoplasm of two cells that is formed following the completion of cleavage furrow ingression during cell division. They are usually present only briefly prior to completion of cytokinesis. However, in some cases, such as the bridges between germ cells during their development, they become stabilised. [PMID:9635420] |
| recycling endosome | cellular component | An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane. [GOC:dph, GOC:jid, GOC:kmv, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101, PMID:21556374, PMID:21562044] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
This protein is involved in 5 target(s):
| Target | Category | Definition |
|---|---|---|
| apoptotic process | biological process | A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263] |
| Rac protein signal transduction | biological process | An intracellular signaling cassette in which a small monomeric GTPase of the Rac subfamily relays a signal. [GOC:bf] |
| actin cytoskeleton organization | biological process | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. [GOC:dph, GOC:jl, GOC:mah] |
| negative regulation of cell migration | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration. [GOC:go_curators] |
| outer dynein arm assembly | biological process | The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein outer arm, an outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. [GOC:BHF, GOC:vk, PMID:19944400] |