An alkaline phosphatase, germ cell type that is encoded in the genome of human. [PRO:DNx, UniProtKB:P10696]
EC 3.1.3.1;
ALP-1;
Alkaline phosphatase Nagao isozyme;
Alkaline phosphatase, placental-like;
Germ cell alkaline phosphatase;
GCAP;
Placental alkaline phosphatase-like;
PLAP-like
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| methylphosphonic acid | Homo sapiens (human) | Ki | 11,000.0000 | 1 | 1 |
| cromolyn sodium | Homo sapiens (human) | IC50 | 12,840.0000 | 2 | 2 |
| 1-(3,4-dihydroxyphenyl)-2-(1-imidazolyl)ethanone | Homo sapiens (human) | IC50 | 1.2000 | 1 | 1 |
| bufrolin | Homo sapiens (human) | IC50 | 1,595.0000 | 2 | 2 |
| benzylphosphonic acid | Homo sapiens (human) | Ki | 580.0000 | 1 | 1 |
| ro 21-7634 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| methylphosphonothiolate | Homo sapiens (human) | Ki | 19,000.0000 | 1 | 1 |
| 1-(3,4-dihydroxyphenyl)-2-[(4,6-dimethyl-2-pyrimidinyl)thio]ethanone | Homo sapiens (human) | IC50 | 0.6000 | 1 | 1 |
| zaprinast | Homo sapiens (human) | IC50 | 6,250.0000 | 1 | 1 |
This protein enables 2 target(s):
| Target | Category | Definition |
|---|---|---|
| alkaline phosphatase activity | molecular function | Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum. [EC:3.1.3.1] |
| metal ion binding | molecular function | Binding to a metal ion. [GOC:ai] |
This protein is located in 3 target(s):
| Target | Category | Definition |
|---|---|---|
| extracellular region | cellular component | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators] |
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| side of membrane | cellular component | A cellular component consisting of one leaflet of a membrane bilayer and any proteins embedded or anchored in it or attached to its surface. [GOC:dos] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
This protein is involved in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| dephosphorylation | biological process | The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. [ISBN:0198506732] |