Liquiritigenin is a flavonoid compound found in licorice root (Glycyrrhiza glabra). It exhibits various biological activities, including antioxidant, anti-inflammatory, and anticancer properties. Research suggests that liquiritigenin may be involved in regulating cellular signaling pathways, such as those involving nuclear factor-kappa B (NF-κB) and mitogen-activated protein kinases (MAPKs). Its potential therapeutic applications in treating inflammatory diseases, cardiovascular disorders, and certain types of cancer are currently under investigation. The compound's unique structure and biological effects make it a promising target for drug discovery and development.'
liquiritigenin: structure given in first source; isolated from Pterocarpus marsupium [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
4',7-dihydroxyflavanone : A dihydroxyflavanone in which the two hydroxy substituents are located at positions 4' and 7. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
liquiritigenin : A dihydroxyflavanone compound having the two hydroxy substituents at the 4'- and 7-positions. Isolated from the root of Glycyrrhizae uralensis, it is a selective agonist for oestrogen receptor beta. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
| Flora | Rank | Flora Definition | Family | Family Definition |
|---|---|---|---|---|
| Pterocarpus | genus | A plant genus of the family FABACEAE. Members contain TRITERPENES.[MeSH] | Fabaceae | The large family of plants characterized by pods. Some are edible and some cause LATHYRISM or FAVISM and other forms of poisoning. Other species yield useful materials like gums from ACACIA and various LECTINS like PHYTOHEMAGGLUTININS from PHASEOLUS. Many of them harbor NITROGEN FIXATION bacteria on their roots. Many but not all species of beans belong to this family.[MeSH] |
| Pterocarpus marsupium | species | [no description available] | Fabaceae | The large family of plants characterized by pods. Some are edible and some cause LATHYRISM or FAVISM and other forms of poisoning. Other species yield useful materials like gums from ACACIA and various LECTINS like PHYTOHEMAGGLUTININS from PHASEOLUS. Many of them harbor NITROGEN FIXATION bacteria on their roots. Many but not all species of beans belong to this family.[MeSH] |
| ID Source | ID |
|---|---|
| PubMed CID | 114829 |
| CHEMBL ID | 252642 |
| CHEBI ID | 28777 |
| SCHEMBL ID | 74552 |
| MeSH ID | M0221321 |
| Synonym |
|---|
| 4h-1-benzopyran-4-one, 2,3-dihydro-7-hydroxy-2-(4-hydroxyphenyl)-, (2s)- |
| 7,4'-dihydroxyflavanone |
| DFV , |
| 7-hydroxy-2-(4-hydroxy-phenyl)-chroman-4-one |
| 4',7-dihydroxyflavanone |
| C09762 |
| liquiritigenin |
| 578-86-9 |
| DB03601 |
| 5-deoxyflavanone |
| (2s)-liquiritigenin |
| LMPK12140061 |
| bdbm50241408 |
| (2s)-7-hydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-4h-chromen-4-one |
| (-)-liquiritigenin |
| CHEBI:28777 , |
| (2s)-7-hydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-4h-1-benzopyran-4-one |
| CHEMBL252642 , |
| liquirtigenin |
| (2s)-7-hydroxy-2-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one |
| A831662 |
| (2s)-7-hydroxy-2-(4-hydroxyphenyl)-3,4-dihydro-2h-1-benzopyran-4-one |
| A826663 |
| (2s)-2-(4-hydroxyphenyl)-7-oxidanyl-2,3-dihydrochromen-4-one |
| 4h-1-benzopyran-4-one, 2,3-dihydro-7-hydroxy-2-(4-hydroxyphenyl)-, (s)- |
| menerba |
| t194lkp9w6 , |
| mf101 |
| unii-t194lkp9w6 |
| S3929 |
| AKOS015903151 |
| flavanone, 4',7-dihydroxy- |
| liquiritigenin [inci] |
| (-)-(2s)-7,4'-dihydroxyflavanone |
| SCHEMBL74552 |
| (2s)-7-hydroxy-2-(4-hydroxyphenyl)chroman-4-one |
| (s)-7-hydroxy-2-(4-hydroxyphenyl)chroman-4-one , |
| FURUXTVZLHCCNA-AWEZNQCLSA-N |
| (s)-2,3-dihydro-7-hydroxy-2-(4-hydroxyphenyl)-4h-1-benzopyran-4-one |
| AC-33949 |
| DTXSID90206493 , |
| (s)-liquiritigenin |
| gtpl8899 |
| liquiritigenin, >=97.0% (hplc) |
| NCGC00370972-01 |
| HY-N0377 |
| CS-6977 |
| BCP18371 |
| AS-18739 |
| Q6557526 |
| mf-101 |
| CCG-267019 |
| 4h-1-benzopyran-4-one, 2,3-dihydro-7-hydroxy-2-(4-hydroxyphenyl)-,(2s)- |
| A869565 |
| STL578166 |
| GLXC-13419 |
| dtxcid90128984 |
Liquiritigenin (LQG) is a natural flavonoid from the herb Glycyrrhiza uralensis Fisch. It has been reported to have positive effects in vitro on osteoblasts activity and bone mineralization.
Liquiritigenin (LQ) has protective effects against various hepatotoxicities.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Liquiritigenin has been isolated and identified from Sargassum pallidum." | ( Design, synthesis, and cholinesterase inhibition assay of liquiritigenin derivatives as anti-Alzheimer's activity. Guan, L; Jia, J; Jiang, H; Peng, D; Zhang, L, 2021) | 1.59 |
| "Liquiritigenin (LQ) has protective effects against various hepatotoxicities. " | ( Liquiritigenin protects against arsenic trioxide-induced liver injury by inhibiting oxidative stress and enhancing mTOR-mediated autophagy. Chu, L; Chu, X; Han, X; Li, L; Wu, Y; Wu, Z; Xue, Y; Zhang, J; Zhang, M; Zhao, Y; Zheng, B, 2021) | 3.51 |
Liquiritigenin treatment of zebrafish embryo significantly enhances the osteogenesis during development. Treatment also resulted in increased apoptosis and enhanced Caspase3 activity. Pretreatment before antimycin A exposure significantly reduced PI3K inactivation, mitochondrial membrane potential dissipation, and ATP loss.
The study aimed to develop a sensitive and simultaneous analytical method for detecting glycyrrhizin, isoliquiritigenin, liquiritigen in rat plasma using liquid chromatography-tandem mass spectrometry. The aim was to apply this analytical method to pharmacokinetic studies.
| Excerpt | Reference | Relevance |
|---|---|---|
| "The objective of this paper was to develop a preparative method for the isolation and purification of liquiritigenin and glycyrrhetic acid from Glycyrrhiza uralensis Fisch using hydrolytic extraction combined with high-speed countercurrent chromatography (HSCCC)." | ( Preparative separation of liquiritigenin and glycyrrhetic acid from Glycyrrhiza uralensis Fisch using hydrolytic extraction combined with high-speed countercurrent chromatography. Lü, H; Shan, H; Wang, H, 2020) | 1.07 |
The absorbed fraction of isoliquiritigenin was high, but the absolute bioavailability was low mainly due to its metabolism. Pharmacokinetics results suggested that the bioavailability of liquiritin, isoliquiritin, glycyrrhizin and its metabolite, Glycyrrhetinic acid, could be improved.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Modification of oral dosage regimen of LQ may not be necessary in patients with acute hepatitis; but human studies are required." | ( Pharmacokinetics of liquiritigenin and its two glucuronides, M1 and M2, in rats with acute hepatitis induced by d-galactosamine/lipopolysaccharide or CCl(4). Baek, SR; Kang, HE; Kim, SG; Kim, YW; Lee, I; Lee, JW; Lee, MG; Sohn, SI, 2010) | 0.68 |
| Role | Description |
|---|---|
| hormone agonist | A chemical substance which binds to specific hormone receptors activating the function of the endocrine glands, the biosynthesis of their secreted hormones, or the action of hormones upon their specific sites. |
| plant metabolite | Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms. |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Class | Description |
|---|---|
| 4',7-dihydroxyflavanone | A dihydroxyflavanone in which the two hydroxy substituents are located at positions 4' and 7. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 16.9330 | 0.0123 | 7.9835 | 43.2770 | AID1645841 |
| G | Vesicular stomatitis virus | Potency | 11.9877 | 0.0123 | 8.9648 | 39.8107 | AID1645842 |
| Interferon beta | Homo sapiens (human) | Potency | 11.9877 | 0.0033 | 9.1582 | 39.8107 | AID1645842 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 11.9877 | 0.0123 | 8.9648 | 39.8107 | AID1645842 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 11.9877 | 0.0123 | 8.9648 | 39.8107 | AID1645842 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 11.9877 | 0.0123 | 8.9648 | 39.8107 | AID1645842 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Neuraminidase | Influenza A virus (A/Wilson-Smith/1933(H1N1)) | IC50 (µMol) | 5.2000 | 0.0000 | 0.5035 | 10.0000 | AID1073043; AID1073044 |
| Acetylcholinesterase | Electrophorus electricus (electric eel) | IC50 (µMol) | 9.1000 | 0.0000 | 0.9453 | 9.9400 | AID1809143 |
| Tyrosine-protein kinase Yes | Homo sapiens (human) | IC50 (µMol) | 11.3000 | 0.0004 | 0.5740 | 8.9000 | AID1649932 |
| Aromatase | Homo sapiens (human) | IC50 (µMol) | 1.2200 | 0.0000 | 1.2904 | 10.0000 | AID321164; AID387613 |
| Tyrosine-protein phosphatase non-receptor type 1 | Homo sapiens (human) | IC50 (µMol) | 70.0000 | 0.0005 | 3.4984 | 9.7600 | AID379219; AID447165; AID612168 |
| Proteasome subunit beta type-5 | Homo sapiens (human) | IC50 (µMol) | 100.0000 | 0.0005 | 0.9394 | 10.0000 | AID1633148 |
| Xanthine dehydrogenase/oxidase | Bos taurus (cattle) | IC50 (µMol) | 11.3000 | 0.0030 | 3.1015 | 9.8000 | AID338975 |
| Cholinesterase | Equus caballus (horse) | IC50 (µMol) | 14.0400 | 0.0000 | 2.2214 | 9.4000 | AID1809144 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Estrogen receptor beta | Homo sapiens (human) | EC50 (µMol) | 0.0365 | 0.0000 | 0.4795 | 4.8900 | AID1855801 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID378533 | Cytotoxicity against human HL60 cells after 72 hrs by MTT assay | 2005 | Journal of natural products, Mar, Volume: 68, Issue:3 | Cytotoxic flavonoids from Platymiscium floribundum. |
| AID1073043 | Inhibition of oseltamivir-resistant Influenza A virus H1N1 B/55/08 neuraminidase by chemiluminescence based assay | 2014 | Journal of natural products, Mar-28, Volume: 77, Issue:3 | Computer-guided approach to access the anti-influenza activity of licorice constituents. |
| AID404181 | Cytotoxicity against mouse LLC cells after 72 hrs by MTT assay | 2008 | Bioorganic & medicinal chemistry, May-15, Volume: 16, Issue:10 | Cytotoxic constituents from Brazilian red propolis and their structure-activity relationship. |
| AID422532 | Inhibition of melanin synthesis in NHEM after 24 hrs by liquid scintillation | 2009 | Journal of natural products, Jan, Volume: 72, Issue:1 | Melanin synthesis inhibitors from Lespedeza cyrtobotrya. |
| AID626863 | Antibacterial activity against Prevotella intermedia ATCC 25611 at 40 ug/ml assessed as growth inhibition by microdilution technique relative to untreated control | 2011 | Journal of natural products, Sep-23, Volume: 74, Issue:9 | Comparative evaluation of two structurally related flavonoids, isoliquiritigenin and liquiritigenin, for their oral infection therapeutic potential. |
| AID404184 | Cytotoxicity against human HT1080 cells after 72 hrs by MTT assay | 2008 | Bioorganic & medicinal chemistry, May-15, Volume: 16, Issue:10 | Cytotoxic constituents from Brazilian red propolis and their structure-activity relationship. |
| AID404179 | Cytotoxicity against mouse colon 26-L5 cells after 72 hrs by MTT assay | 2008 | Bioorganic & medicinal chemistry, May-15, Volume: 16, Issue:10 | Cytotoxic constituents from Brazilian red propolis and their structure-activity relationship. |
| AID612168 | Inhibition of human recombinant PTP1B assessed as p-nitorphenol production after 30 mins | 2011 | Bioorganic & medicinal chemistry, Jun-01, Volume: 19, Issue:11 | New 5-deoxyflavonoids and their inhibitory effects on protein tyrosine phosphatase 1B (PTP1B) activity. |
| AID387613 | Inhibition of human aromatase by fluorometric assay | 2008 | Bioorganic & medicinal chemistry, Sep-15, Volume: 16, Issue:18 | Screening of herbal constituents for aromatase inhibitory activity. |
| AID404180 | Cytotoxicity against mouse B16-BL6 cells after 72 hrs by MTT assay | 2008 | Bioorganic & medicinal chemistry, May-15, Volume: 16, Issue:10 | Cytotoxic constituents from Brazilian red propolis and their structure-activity relationship. |
| AID1875269 | Inhibition of MMP13 in human U2OS cells at 5 umol/L by peptide microarray-based fluorescence assay | 2022 | Journal of natural products, 10-28, Volume: 85, Issue:10 | Discovery of Phenolic Matrix Metalloproteinase Inhibitors by Peptide Microarray for Osteosarcoma Treatment. |
| AID626957 | Antibacterial activity against Prevotella intermedia ATCC 25611 by microdilution technique in presence of 10% unstimulated whole salive | 2011 | Journal of natural products, Sep-23, Volume: 74, Issue:9 | Comparative evaluation of two structurally related flavonoids, isoliquiritigenin and liquiritigenin, for their oral infection therapeutic potential. |
| AID339156 | Antihyperlipidemic activity in diet-induced hyperlipidemic rat model assessed as serum HDLC level at 40 mg/kg, po administered once daily in morning through gastric intubation for 14 days measured after 4 hrs of last dose | 1993 | Journal of natural products, Jul, Volume: 56, Issue:7 | Antihyperlipidemic effect of flavonoids from Pterocarpus marsupium. |
| AID404183 | Cytotoxicity against human HeLa cells after 72 hrs by MTT assay | 2008 | Bioorganic & medicinal chemistry, May-15, Volume: 16, Issue:10 | Cytotoxic constituents from Brazilian red propolis and their structure-activity relationship. |
| AID1453625 | Inhibition of mushroom tyrosinase at 10 uM using L-tyrosine as substrate incubated for 15 mins followed by substrate addition relative to control | 2017 | Bioorganic & medicinal chemistry, 07-15, Volume: 25, Issue:14 | Screening for bioactive natural products from a 67-compound library of Glycyrrhiza inflata. |
| AID494422 | Cytotoxicity against human DU145 cells after 72 hrs by MTT assay | 2010 | European journal of medicinal chemistry, Aug, Volume: 45, Issue:8 | Synthesis and antitumor activity of liquiritigenin thiosemicarbazone derivatives. |
| AID1372447 | Antitussive activity in ammonia liquor-induced cough ICR mouse model assessed as reduction in cough frequency at 50 mg/kg, po treated with ammonia 1 hr before and 1 to 5 hrs after test compound dosing measured for 3 mins in presence of opioid receptor ant | 2018 | Bioorganic & medicinal chemistry, 01-01, Volume: 26, Issue:1 | Antitussive and expectorant activities of licorice and its major compounds. |
| AID1372448 | Expectorant activity in ICR mouse assessed as increase in phenol red secretion in trachea at 50 mg/kg, po for 3 days followed by phenol red treatment at 30 mins post last dose measured after 30 mins by UV-Vis spectrophotometric assay relative to control | 2018 | Bioorganic & medicinal chemistry, 01-01, Volume: 26, Issue:1 | Antitussive and expectorant activities of licorice and its major compounds. |
| AID378532 | Cytotoxicity against human CEM cells after 72 hrs by MTT assay | 2005 | Journal of natural products, Mar, Volume: 68, Issue:3 | Cytotoxic flavonoids from Platymiscium floribundum. |
| AID339158 | Antihyperlipidemic activity in diet-induced hyperlipidemic rat model assessed as serum VLDLC level at 40 mg/kg, po administered once daily in morning through gastric intubation for 14 days measured after 4 hrs of last dose | 1993 | Journal of natural products, Jul, Volume: 56, Issue:7 | Antihyperlipidemic effect of flavonoids from Pterocarpus marsupium. |
| AID1875272 | Inhibition of MMP3 in human U2OS cells at 5 umol/L by peptide microarray-based fluorescence assay | 2022 | Journal of natural products, 10-28, Volume: 85, Issue:10 | Discovery of Phenolic Matrix Metalloproteinase Inhibitors by Peptide Microarray for Osteosarcoma Treatment. |
| AID458820 | Inhibition of Spanish flu (A/Bervig_Mission/1/18) neuraminidase | 2010 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 20, Issue:3 | Inhibition of neuraminidase activity by polyphenol compounds isolated from the roots of Glycyrrhiza uralensis. |
| AID1453619 | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production at 10 uM after 24 hrs by Griess reagent based assay relative to control | 2017 | Bioorganic & medicinal chemistry, 07-15, Volume: 25, Issue:14 | Screening for bioactive natural products from a 67-compound library of Glycyrrhiza inflata. |
| AID469801 | Estrogenic activity in human T47D cells assessed as drug level causing stimulation of cell proliferation equivalent to 100 pM estradiol after 96 hrs by alamar blue assay | 2009 | Journal of natural products, Dec, Volume: 72, Issue:12 | Flavonoids from the heartwood of the Thai medicinal plant Dalbergia parviflora and their effects on estrogenic-responsive human breast cancer cells. |
| AID378534 | Cytotoxicity against human HCT8 cells after 72 hrs by MTT assay | 2005 | Journal of natural products, Mar, Volume: 68, Issue:3 | Cytotoxic flavonoids from Platymiscium floribundum. |
| AID469805 | Estrogenic activity in luciferase transfected human T47D cells assessed as drug level causing stimulation of cell proliferation equivalent to 10 pM estradiol by luciferase reporter gene assay | 2009 | Journal of natural products, Dec, Volume: 72, Issue:12 | Flavonoids from the heartwood of the Thai medicinal plant Dalbergia parviflora and their effects on estrogenic-responsive human breast cancer cells. |
| AID494421 | Cytotoxicity against human K562 cells after 72 hrs by MTT assay | 2010 | European journal of medicinal chemistry, Aug, Volume: 45, Issue:8 | Synthesis and antitumor activity of liquiritigenin thiosemicarbazone derivatives. |
| AID626891 | Antiinflammatory activity in human U937 cells assessed as inhibition of LPS-induced TNFalpha secretion at 5 ug/ml after 24 hrs by ELISA relative to control | 2011 | Journal of natural products, Sep-23, Volume: 74, Issue:9 | Comparative evaluation of two structurally related flavonoids, isoliquiritigenin and liquiritigenin, for their oral infection therapeutic potential. |
| AID626887 | Inhibition of Porphyromonas gingivalis ATCC 33277 collagenase assessed at 100 ug/ml after 4 hrs by fluorimetric analysis relative to control | 2011 | Journal of natural products, Sep-23, Volume: 74, Issue:9 | Comparative evaluation of two structurally related flavonoids, isoliquiritigenin and liquiritigenin, for their oral infection therapeutic potential. |
| AID1372142 | Inhibition of recombinant human CYP1A1 expressed in yeast microsomal membranes at 10 uM by fluorescence assay relative to control | |||
| AID339161 | Antihyperlipidemic activity in Triton-induced hyperlipidemic rat model assessed as serum total cholesterol level at 75 mg/kg, po administered for 2 days through gastric intubation immediately and 20 hrs after triton challenge measured after 4 hrs of last | 1993 | Journal of natural products, Jul, Volume: 56, Issue:7 | Antihyperlipidemic effect of flavonoids from Pterocarpus marsupium. |
| AID1484045 | Antiproliferative activity against human HepG2 cells at 10 uM after 24 hrs by MTS assay relative to control | 2017 | Journal of natural products, 02-24, Volume: 80, Issue:2 | Glycybridins A-K, Bioactive Phenolic Compounds from Glycyrrhiza glabra. |
| AID404182 | Cytotoxicity against human A549 cells after 72 hrs by MTT assay | 2008 | Bioorganic & medicinal chemistry, May-15, Volume: 16, Issue:10 | Cytotoxic constituents from Brazilian red propolis and their structure-activity relationship. |
| AID347889 | Inhibition of human recombinant PTP1B | 2008 | Bioorganic & medicinal chemistry, Dec-15, Volume: 16, Issue:24 | Flavanones from the stem bark of Erythrina abyssinica. |
| AID775570 | Inhibition of PTP1B (unknown origin) using p-nitrophenyl phosphate as substrate at 100 uM | 2013 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 23, Issue:21 | Evaluation of licorice flavonoids as protein tyrosine phosphatase 1B inhibitors. |
| AID313354 | Cytotoxicity against human PANC1 cells in nutrient deprived medium after 24 hrs | 2008 | Bioorganic & medicinal chemistry, Jan-01, Volume: 16, Issue:1 | Constituents of Brazilian red propolis and their preferential cytotoxic activity against human pancreatic PANC-1 cancer cell line in nutrient-deprived condition. |
| AID626866 | Inhibition of Porphyromonas gingivalis ATCC 33277 collagenase assessed as remaining activity at 100 ug/ml after 4 hrs by fluorimetric analysis relative to control | 2011 | Journal of natural products, Sep-23, Volume: 74, Issue:9 | Comparative evaluation of two structurally related flavonoids, isoliquiritigenin and liquiritigenin, for their oral infection therapeutic potential. |
| AID1809144 | Inhibition of equine serum BuChE using butyrylthiocholine chloride as substrate incubated for 15 to 20 mins by Ellman's method | 2021 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 52 | Design, synthesis, and cholinesterase inhibition assay of liquiritigenin derivatives as anti-Alzheimer's activity. |
| AID378535 | Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay | 2005 | Journal of natural products, Mar, Volume: 68, Issue:3 | Cytotoxic flavonoids from Platymiscium floribundum. |
| AID1453614 | Growth inhibition of human MCF7 cells at 10 uM after 24 hrs by MTS assay relative to control | 2017 | Bioorganic & medicinal chemistry, 07-15, Volume: 25, Issue:14 | Screening for bioactive natural products from a 67-compound library of Glycyrrhiza inflata. |
| AID1875271 | Inhibition of MMP7 in human U2OS cells at 5 umol/L by peptide microarray-based fluorescence assay | 2022 | Journal of natural products, 10-28, Volume: 85, Issue:10 | Discovery of Phenolic Matrix Metalloproteinase Inhibitors by Peptide Microarray for Osteosarcoma Treatment. |
| AID1484039 | Activation of Nrf2 (unknown origin) expressed in human HepG2 cells at 10 uM after 6 hrs by ARE-driven luciferase reporter gene assay relative to control | 2017 | Journal of natural products, 02-24, Volume: 80, Issue:2 | Glycybridins A-K, Bioactive Phenolic Compounds from Glycyrrhiza glabra. |
| AID1372143 | Inhibition of human CYP1B1 expressed in yeast microsomal membranes at 10 uM using 7-ethoxyresorufin as substrate by fluorescence assay relative to control | |||
| AID1809146 | Antioxidant activity assessed as ABTS radical scavenging activity | 2021 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 52 | Design, synthesis, and cholinesterase inhibition assay of liquiritigenin derivatives as anti-Alzheimer's activity. |
| AID1372445 | Antitussive activity in ammonia liquor-induced cough ICR mouse model assessed as reduction in cough frequency at 50 mg/kg, po treated with ammonia 1 hr before and 1 hr after test compound dosing measured for 3 mins in presence of 5-HT receptor antagonist | 2018 | Bioorganic & medicinal chemistry, 01-01, Volume: 26, Issue:1 | Antitussive and expectorant activities of licorice and its major compounds. |
| AID1484046 | Antiproliferative activity against human A549 cells at 10 uM after 24 hrs by MTS assay relative to control | 2017 | Journal of natural products, 02-24, Volume: 80, Issue:2 | Glycybridins A-K, Bioactive Phenolic Compounds from Glycyrrhiza glabra. |
| AID494423 | Cytotoxicity against human SGC7901 cells after 72 hrs by MTT assay | 2010 | European journal of medicinal chemistry, Aug, Volume: 45, Issue:8 | Synthesis and antitumor activity of liquiritigenin thiosemicarbazone derivatives. |
| AID1073038 | Antiviral activity against Influenza A virus (A/Hong Kong/1/1968(H3N2)) infected in MDCK cells assessed as inhibition of virus-induced cytopathic effect at 50 uM after 48 hrs | 2014 | Journal of natural products, Mar-28, Volume: 77, Issue:3 | Computer-guided approach to access the anti-influenza activity of licorice constituents. |
| AID469799 | Estrogenic activity in human T47D cells assessed as drug level causing stimulation of cell proliferation equivalent to 10 pM estradiol after 96 hrs by alamar blue assay | 2009 | Journal of natural products, Dec, Volume: 72, Issue:12 | Flavonoids from the heartwood of the Thai medicinal plant Dalbergia parviflora and their effects on estrogenic-responsive human breast cancer cells. |
| AID626888 | Inhibition of human MMP9 assessed as remaining activity at 5 ug/ml after 4 hrs by fluorimetric analysis relative to control | 2011 | Journal of natural products, Sep-23, Volume: 74, Issue:9 | Comparative evaluation of two structurally related flavonoids, isoliquiritigenin and liquiritigenin, for their oral infection therapeutic potential. |
| AID469806 | Estrogenic activity in luciferase transfected human T47D cells assessed as drug level causing stimulation of cell proliferation equivalent to 100 pM estradiol by luciferase reporter gene assay | 2009 | Journal of natural products, Dec, Volume: 72, Issue:12 | Flavonoids from the heartwood of the Thai medicinal plant Dalbergia parviflora and their effects on estrogenic-responsive human breast cancer cells. |
| AID1410197 | Cytotoxicity against human Ishikawa cells assessed as cell death | 2018 | Journal of natural products, 04-27, Volume: 81, Issue:4 | Estrogen Receptor (ER) Subtype Selectivity Identifies 8-Prenylapigenin as an ERβ Agonist from Glycyrrhiza inflata and Highlights the Importance of Chemical and Biological Authentication. |
| AID469802 | Estrogenic activity in human MCF7 cells assessed as drug level causing stimulation of cell proliferation equivalent to 10 pM estradiol after 96 hrs by alamar blue assay | 2009 | Journal of natural products, Dec, Volume: 72, Issue:12 | Flavonoids from the heartwood of the Thai medicinal plant Dalbergia parviflora and their effects on estrogenic-responsive human breast cancer cells. |
| AID494425 | Cytotoxicity against human HeLa cells after 72 hrs by MTT assay | 2010 | European journal of medicinal chemistry, Aug, Volume: 45, Issue:8 | Synthesis and antitumor activity of liquiritigenin thiosemicarbazone derivatives. |
| AID626894 | Antiinflammatory activity in human U937 cells assessed as inhibition of LPS-induced IL1-beta secretion at 5 ug/ml after 24 hrs by ELISA relative to control | 2011 | Journal of natural products, Sep-23, Volume: 74, Issue:9 | Comparative evaluation of two structurally related flavonoids, isoliquiritigenin and liquiritigenin, for their oral infection therapeutic potential. |
| AID1875274 | Inhibition of MMP1 in human U2OS cells at 5 umol/L by peptide microarray-based fluorescence assay | 2022 | Journal of natural products, 10-28, Volume: 85, Issue:10 | Discovery of Phenolic Matrix Metalloproteinase Inhibitors by Peptide Microarray for Osteosarcoma Treatment. |
| AID419369 | Antioxidant activity assessed as DPPH radical scavenging activity at 200 ug after 30 mins by UV-visible spectrophotometry | 2009 | European journal of medicinal chemistry, May, Volume: 44, Issue:5 | Synthesis of (+/-)Abyssinone I and related compounds: Their anti-oxidant and cytotoxic activities. |
| AID626889 | Inhibition of human MMP9 assessed as remaining activity at 25 ug/ml after 4 hrs by fluorimetric analysis relative to control | 2011 | Journal of natural products, Sep-23, Volume: 74, Issue:9 | Comparative evaluation of two structurally related flavonoids, isoliquiritigenin and liquiritigenin, for their oral infection therapeutic potential. |
| AID1484040 | Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production at 10 uM after 24 hrs by Griess assay relative to control | 2017 | Journal of natural products, 02-24, Volume: 80, Issue:2 | Glycybridins A-K, Bioactive Phenolic Compounds from Glycyrrhiza glabra. |
| AID1372438 | Antitussive activity in po dosed ammonia liquor-induced cough ICR mouse model assessed as reduction in cough frequency treated with ammonia 1 hr before and 1 to 5 hrs after test compound dosing measured for 3 mins | 2018 | Bioorganic & medicinal chemistry, 01-01, Volume: 26, Issue:1 | Antitussive and expectorant activities of licorice and its major compounds. |
| AID1372449 | Expectorant activity in ICR mouse assessed as phenol red secretion in trachea at 20 to 50 mg/kg, po for 3 days followed by phenol red treatment at 30 mins post last dose measured after 30 mins by UV-Vis spectrophotometric assay relative to control | 2018 | Bioorganic & medicinal chemistry, 01-01, Volume: 26, Issue:1 | Antitussive and expectorant activities of licorice and its major compounds. |
| AID626903 | Cytotoxicity against human U937 cells assessed as loss of cell viability by MTT assay | 2011 | Journal of natural products, Sep-23, Volume: 74, Issue:9 | Comparative evaluation of two structurally related flavonoids, isoliquiritigenin and liquiritigenin, for their oral infection therapeutic potential. |
| AID338974 | Inhibition of cow milk xanthine oxidase at 50 ug/mL | |||
| AID338975 | Inhibition of cow milk xanthine oxidase | |||
| AID1649932 | Inhibition of YES (unknown origin) | 2019 | European journal of medicinal chemistry, Mar-15, Volume: 166 | Pharmacological urate-lowering approaches in chronic kidney disease. |
| AID1484037 | Inhibition of recombinant human PTP1B using pNPP as substrate at 10 uM after 30 mins relative to control | 2017 | Journal of natural products, 02-24, Volume: 80, Issue:2 | Glycybridins A-K, Bioactive Phenolic Compounds from Glycyrrhiza glabra. |
| AID339159 | Antihyperlipidemic activity in diet-induced hyperlipidemic rat model assessed as ratio of HDLC to serum total cholesterol level at 40 mg/kg, po administered once daily in morning through gastric intubation for 14 days measured after 4 hrs of last dose | 1993 | Journal of natural products, Jul, Volume: 56, Issue:7 | Antihyperlipidemic effect of flavonoids from Pterocarpus marsupium. |
| AID626890 | Inhibition of human MMP9 assessed as remaining activity at 100 ug/ml after 4 hrs by fluorimetric analysis relative to control | 2011 | Journal of natural products, Sep-23, Volume: 74, Issue:9 | Comparative evaluation of two structurally related flavonoids, isoliquiritigenin and liquiritigenin, for their oral infection therapeutic potential. |
| AID447165 | Inhibition of recombinant human PTP1B assessed as hydrolysis of p-nitrophenyl phosphate after 30 mins | 2009 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 19, Issue:17 | Inhibitory effect of chalcones and their derivatives from Glycyrrhiza inflata on protein tyrosine phosphatase 1B. |
| AID1484047 | Antiproliferative activity against human MCF7 cells at 10 uM after 24 hrs by MTS assay relative to control | 2017 | Journal of natural products, 02-24, Volume: 80, Issue:2 | Glycybridins A-K, Bioactive Phenolic Compounds from Glycyrrhiza glabra. |
| AID494424 | Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay | 2010 | European journal of medicinal chemistry, Aug, Volume: 45, Issue:8 | Synthesis and antitumor activity of liquiritigenin thiosemicarbazone derivatives. |
| AID1484034 | Inhibition of tyrosinase (unknown origin) using L-tyrosine as substrate at 10 uM preincubated for 15 mins followed by substrate addition relative to control | 2017 | Journal of natural products, 02-24, Volume: 80, Issue:2 | Glycybridins A-K, Bioactive Phenolic Compounds from Glycyrrhiza glabra. |
| AID626892 | Antiinflammatory activity in human U937 cells assessed as inhibition of LPS-induced CCL5 secretion at 5 ug/ml after 24 hrs by ELISA relative to control | 2011 | Journal of natural products, Sep-23, Volume: 74, Issue:9 | Comparative evaluation of two structurally related flavonoids, isoliquiritigenin and liquiritigenin, for their oral infection therapeutic potential. |
| AID379219 | Inhibition of human recombinant PTP1B | 2006 | Journal of natural products, Nov, Volume: 69, Issue:11 | Protein tyrosine phosphatase-1B inhibitory activity of isoprenylated flavonoids isolated from Erythrina mildbraedii. |
| AID419368 | Antioxidant activity assessed as ferric ion reducing activity at 200 ug after 20 mins by UV-visible spectrophotometry | 2009 | European journal of medicinal chemistry, May, Volume: 44, Issue:5 | Synthesis of (+/-)Abyssinone I and related compounds: Their anti-oxidant and cytotoxic activities. |
| AID458821 | Inhibition of Spanish flu (A/Bervig_Mission/1/18) neuraminidase by noncompetitive inhibition assay | 2010 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 20, Issue:3 | Inhibition of neuraminidase activity by polyphenol compounds isolated from the roots of Glycyrrhiza uralensis. |
| AID1463920 | Activation of Nrf2 (unknown origin) expressed in human HepG2 cells at 10 uM incubated for 6 hrs by ARE-driven luciferase reporter gene assay relative to untreated control | 2017 | Bioorganic & medicinal chemistry, 10-15, Volume: 25, Issue:20 | Nrf2 activators from Glycyrrhiza inflata and their hepatoprotective activities against CCl |
| AID385354 | Cytotoxicity against rat H4IIE cells after 24 hrs by MTT assay | 2008 | Journal of natural products, Apr, Volume: 71, Issue:4 | Prenylated flavonoid derivatives from the bark of Erythrina addisoniae. |
| AID1875270 | Inhibition of MMP9 in human U2OS cells at 5 umol/L by peptide microarray-based fluorescence assay | 2022 | Journal of natural products, 10-28, Volume: 85, Issue:10 | Discovery of Phenolic Matrix Metalloproteinase Inhibitors by Peptide Microarray for Osteosarcoma Treatment. |
| AID1484042 | Inhibition of LPS-induced NF-kappaB (unknown origin) transactivation expressed in human SW480 cells at 10 uM administered 1 hr after LPS stimulation measured after 6 hrs by luciferase reporter gene assay relative to control | 2017 | Journal of natural products, 02-24, Volume: 80, Issue:2 | Glycybridins A-K, Bioactive Phenolic Compounds from Glycyrrhiza glabra. |
| AID1809143 | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate incubated for 15 to 20 mins by Ellman's method | 2021 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 52 | Design, synthesis, and cholinesterase inhibition assay of liquiritigenin derivatives as anti-Alzheimer's activity. |
| AID469804 | Estrogenic activity in luciferase transfected human MCF7 cells assessed as drug level causing stimulation of cell proliferation equivalent to 100 pM estradiol by luciferase reporter gene assay | 2009 | Journal of natural products, Dec, Volume: 72, Issue:12 | Flavonoids from the heartwood of the Thai medicinal plant Dalbergia parviflora and their effects on estrogenic-responsive human breast cancer cells. |
| AID321165 | Inhibition of human aromatase in placental microsomes relative to aminogluthetimide | 2008 | Bioorganic & medicinal chemistry, Feb-01, Volume: 16, Issue:3 | New 7,8-benzoflavanones as potent aromatase inhibitors: synthesis and biological evaluation. |
| AID1073037 | Cytotoxicity against MDCK cells after 72 hrs | 2014 | Journal of natural products, Mar-28, Volume: 77, Issue:3 | Computer-guided approach to access the anti-influenza activity of licorice constituents. |
| AID1410198 | Cytotoxicity against human MDA-MB-231/beta41 cells assessed as cell death | 2018 | Journal of natural products, 04-27, Volume: 81, Issue:4 | Estrogen Receptor (ER) Subtype Selectivity Identifies 8-Prenylapigenin as an ERβ Agonist from Glycyrrhiza inflata and Highlights the Importance of Chemical and Biological Authentication. |
| AID1809145 | Selectivity index, ratio of IC50 for equine serum BuChE using butyrylthiocholine chloride as substrate to IC50 for electric eel AChE using acetylthiocholine iodide as substrate incubated for 15 to 20 mins by Ellman's method | 2021 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 52 | Design, synthesis, and cholinesterase inhibition assay of liquiritigenin derivatives as anti-Alzheimer's activity. |
| AID378536 | Cytotoxicity against mouse B16 cells after 72 hrs by MTT assay | 2005 | Journal of natural products, Mar, Volume: 68, Issue:3 | Cytotoxic flavonoids from Platymiscium floribundum. |
| AID1073042 | Inhibition of Influenza A virus (A/Hong Kong/1/1968(H3N2)) neuraminidase by chemiluminescence based assay | 2014 | Journal of natural products, Mar-28, Volume: 77, Issue:3 | Computer-guided approach to access the anti-influenza activity of licorice constituents. |
| AID339154 | Antihyperlipidemic activity in diet-induced hyperlipidemic rat model assessed as serum total cholesterol level at 40 mg/kg, po administered once daily in morning through gastric intubation for 14 days measured after 4 hrs of last dose | 1993 | Journal of natural products, Jul, Volume: 56, Issue:7 | Antihyperlipidemic effect of flavonoids from Pterocarpus marsupium. |
| AID339160 | Antihyperlipidemic activity in diet-induced hyperlipidemic rat model assessed as atherogenic index at 40 mg/kg, po administered once daily in morning through gastric intubation for 14 days measured after 4 hrs of last dose | 1993 | Journal of natural products, Jul, Volume: 56, Issue:7 | Antihyperlipidemic effect of flavonoids from Pterocarpus marsupium. |
| AID422533 | Cytotoxicity against NHEM cells assessed as cell viability 24 hrs by WST-8 assay | 2009 | Journal of natural products, Jan, Volume: 72, Issue:1 | Melanin synthesis inhibitors from Lespedeza cyrtobotrya. |
| AID1633148 | Inhibition of chymotrypsin-like activity of purified human erythrocyte 20S proteasome assessed as decrease in AMC hydrolysis using Suc-LLVY-AMC as substrate preincubated for 10 mins and measured by fluorescence based method | 2019 | European journal of medicinal chemistry, Apr-01, Volume: 167 | Another look at phenolic compounds in cancer therapy the effect of polyphenols on ubiquitin-proteasome system. |
| AID469800 | Estrogenic activity in human MCF7 cells assessed as drug level causing stimulation of cell proliferation equivalent to 100 pM estradiol after 96 hrs by alamar blue assay | 2009 | Journal of natural products, Dec, Volume: 72, Issue:12 | Flavonoids from the heartwood of the Thai medicinal plant Dalbergia parviflora and their effects on estrogenic-responsive human breast cancer cells. |
| AID626864 | Inhibition of Porphyromonas gingivalis ATCC 33277 collagenase assessed as remaining activity at 5 ug/ml after 4 hrs by fluorimetric analysis relative to control | 2011 | Journal of natural products, Sep-23, Volume: 74, Issue:9 | Comparative evaluation of two structurally related flavonoids, isoliquiritigenin and liquiritigenin, for their oral infection therapeutic potential. |
| AID1855801 | Agonist activity at ER-beta (unknown origin) | 2022 | European journal of medicinal chemistry, Nov-05, Volume: 241 | An overview on Estrogen receptors signaling and its ligands in breast cancer. |
| AID469803 | Estrogenic activity in luciferase transfected human MCF7 cells assessed as drug level causing stimulation of cell proliferation equivalent to 10 pM estradiol by luciferase reporter gene assay | 2009 | Journal of natural products, Dec, Volume: 72, Issue:12 | Flavonoids from the heartwood of the Thai medicinal plant Dalbergia parviflora and their effects on estrogenic-responsive human breast cancer cells. |
| AID1372435 | Antitussive activity in ammonia liquor-induced cough ICR mouse model assessed as reduction in cough frequency at 50 mg/kg, po treated with ammonia 1 hr before and 5 hrs after test compound dosing measured for 3 mins relative to control | 2018 | Bioorganic & medicinal chemistry, 01-01, Volume: 26, Issue:1 | Antitussive and expectorant activities of licorice and its major compounds. |
| AID1372437 | Antitussive activity in ammonia liquor-induced cough ICR mouse model assessed as reduction in cough frequency at 50 mg/kg, po treated with ammonia 1 hr before and 1 to 5 hrs after test compound dosing measured for 3 mins relative to control | 2018 | Bioorganic & medicinal chemistry, 01-01, Volume: 26, Issue:1 | Antitussive and expectorant activities of licorice and its major compounds. |
| AID1453621 | Inhibition of LPS-induced NF-kappaB transcription (unknown origin) expressed in human SW480 cells at 10 uM by luciferase reporter gene assay | 2017 | Bioorganic & medicinal chemistry, 07-15, Volume: 25, Issue:14 | Screening for bioactive natural products from a 67-compound library of Glycyrrhiza inflata. |
| AID1484048 | Antiproliferative activity against human SW480 cells at 10 uM after 24 hrs by MTS assay relative to control | 2017 | Journal of natural products, 02-24, Volume: 80, Issue:2 | Glycybridins A-K, Bioactive Phenolic Compounds from Glycyrrhiza glabra. |
| AID339157 | Antihyperlipidemic activity in diet-induced hyperlipidemic rat model assessed as serum LDLC level at 40 mg/kg, po administered once daily in morning through gastric intubation for 14 days measured after 4 hrs of last dose | 1993 | Journal of natural products, Jul, Volume: 56, Issue:7 | Antihyperlipidemic effect of flavonoids from Pterocarpus marsupium. |
| AID1453616 | Growth inhibition of human HepG2 cells at 10 uM after 24 hrs by MTS assay relative to control | 2017 | Bioorganic & medicinal chemistry, 07-15, Volume: 25, Issue:14 | Screening for bioactive natural products from a 67-compound library of Glycyrrhiza inflata. |
| AID1453615 | Growth inhibition of human SW480 cells at 10 uM after 24 hrs by MTS assay relative to control | 2017 | Bioorganic & medicinal chemistry, 07-15, Volume: 25, Issue:14 | Screening for bioactive natural products from a 67-compound library of Glycyrrhiza inflata. |
| AID1410191 | Estrogenic activity at ERalpha in human Ishikawa cells assessed as induction of alkaline phosphatase activity using p-nitrophenol as substrate treated for 96 hrs followed by substrate addition by spectrophotometric method | 2018 | Journal of natural products, 04-27, Volume: 81, Issue:4 | Estrogen Receptor (ER) Subtype Selectivity Identifies 8-Prenylapigenin as an ERβ Agonist from Glycyrrhiza inflata and Highlights the Importance of Chemical and Biological Authentication. |
| AID1372446 | Antitussive activity in ammonia liquor-induced cough ICR mouse model assessed as reduction in cough frequency at 50 mg/kg, po treated with ammonia 1 hr before and 1 hr after test compound dosing measured for 3 mins in presence of ATP-sensitive K+ channel | 2018 | Bioorganic & medicinal chemistry, 01-01, Volume: 26, Issue:1 | Antitussive and expectorant activities of licorice and its major compounds. |
| AID339163 | Antihyperlipidemic activity in Triton-induced hyperlipidemic rat model assessed as serum total lipid level at 75 mg/kg, po administered for 2 days through gastric intubation immediately and 20 hrs after triton challenge measured after 4 hrs of last dose | 1993 | Journal of natural products, Jul, Volume: 56, Issue:7 | Antihyperlipidemic effect of flavonoids from Pterocarpus marsupium. |
| AID321164 | Inhibition of human aromatase in placental microsomes | 2008 | Bioorganic & medicinal chemistry, Feb-01, Volume: 16, Issue:3 | New 7,8-benzoflavanones as potent aromatase inhibitors: synthesis and biological evaluation. |
| AID1410193 | Estrogenic activity at ERbeta (unknown origin) expressed in human MDA-MB-231/beta41 cells after 18 hrs by renilla luciferase reporter gene assay | 2018 | Journal of natural products, 04-27, Volume: 81, Issue:4 | Estrogen Receptor (ER) Subtype Selectivity Identifies 8-Prenylapigenin as an ERβ Agonist from Glycyrrhiza inflata and Highlights the Importance of Chemical and Biological Authentication. |
| AID626895 | Antiinflammatory activity in human U937 cells assessed as inhibition of LPS-induced IL8 secretion at 5 ug/ml after 24 hrs by ELISA relative to control | 2011 | Journal of natural products, Sep-23, Volume: 74, Issue:9 | Comparative evaluation of two structurally related flavonoids, isoliquiritigenin and liquiritigenin, for their oral infection therapeutic potential. |
| AID626952 | Antibacterial activity against Prevotella intermedia ATCC 25611 by microdilution technique in presence of 1% fetal bovine serum | 2011 | Journal of natural products, Sep-23, Volume: 74, Issue:9 | Comparative evaluation of two structurally related flavonoids, isoliquiritigenin and liquiritigenin, for their oral infection therapeutic potential. |
| AID1073045 | Inhibition of Influenza A virus J/8178/09 neuraminidase by chemiluminescence based assay | 2014 | Journal of natural products, Mar-28, Volume: 77, Issue:3 | Computer-guided approach to access the anti-influenza activity of licorice constituents. |
| AID1301467 | Inhibition of recombinant human PTP1B assessed as hydrolysis of p-nitrophenyl phosphate at 25 uM after 30 mins relative to control | 2016 | Journal of natural products, Feb-26, Volume: 79, Issue:2 | Bioactive Constituents of Glycyrrhiza uralensis (Licorice): Discovery of the Effective Components of a Traditional Herbal Medicine. |
| AID626904 | Antiinflammatory activity in human U937 cells assessed as inhibition of LPS-induced MMP9 secretion at 5 ug/ml after 24 hrs by ELISA relative to control | 2011 | Journal of natural products, Sep-23, Volume: 74, Issue:9 | Comparative evaluation of two structurally related flavonoids, isoliquiritigenin and liquiritigenin, for their oral infection therapeutic potential. |
| AID419370 | Cytotoxicity against human MCF7 cells at 25 to 150 uM after 72 hrs by MTT assay | 2009 | European journal of medicinal chemistry, May, Volume: 44, Issue:5 | Synthesis of (+/-)Abyssinone I and related compounds: Their anti-oxidant and cytotoxic activities. |
| AID626893 | Antiinflammatory activity in human U937 cells assessed as inhibition of LPS-induced of IL6 secretion at 5 ug/ml after 24 hrs by ELISA relative to control | 2011 | Journal of natural products, Sep-23, Volume: 74, Issue:9 | Comparative evaluation of two structurally related flavonoids, isoliquiritigenin and liquiritigenin, for their oral infection therapeutic potential. |
| AID1875273 | Inhibition of MMP2 in human U2OS cells at 5 umol/L by peptide microarray-based fluorescence assay | 2022 | Journal of natural products, 10-28, Volume: 85, Issue:10 | Discovery of Phenolic Matrix Metalloproteinase Inhibitors by Peptide Microarray for Osteosarcoma Treatment. |
| AID1073044 | Inhibition of Influenza A virus (A/Puerto Rico/8/1934(H1N1)) neuraminidase by chemiluminescence based assay | 2014 | Journal of natural products, Mar-28, Volume: 77, Issue:3 | Computer-guided approach to access the anti-influenza activity of licorice constituents. |
| AID1334868 | Inhibition of LPS-stimulated nitric oxide production in ddy mouse peritoneal macrophages measured after 20 hrs by Greiss method | 2017 | Bioorganic & medicinal chemistry, 01-15, Volume: 25, Issue:2 | Structure-activity relationship of the inhibitory effects of flavonoids on nitric oxide production in RAW264.7 cells. |
| AID626906 | Inhibition of LPS-induced AP-1 activation in human U937 cells at 5 ug/ml after 1 hr relative to control | 2011 | Journal of natural products, Sep-23, Volume: 74, Issue:9 | Comparative evaluation of two structurally related flavonoids, isoliquiritigenin and liquiritigenin, for their oral infection therapeutic potential. |
| AID626865 | Inhibition of Porphyromonas gingivalis ATCC 33277 collagenase assessed as remaining activity at 25 ug/ml after 4 hrs by fluorimetric analysis relative to control | 2011 | Journal of natural products, Sep-23, Volume: 74, Issue:9 | Comparative evaluation of two structurally related flavonoids, isoliquiritigenin and liquiritigenin, for their oral infection therapeutic potential. |
| AID1073039 | Antiviral activity against Influenza A virus J/8178/09 infected in MDCK cells assessed as inhibition of virus-induced cytopathic effect at 50 uM after 48 hrs | 2014 | Journal of natural products, Mar-28, Volume: 77, Issue:3 | Computer-guided approach to access the anti-influenza activity of licorice constituents. |
| AID1453623 | Inhibition of recombinant human PTP1B using p-nitrophenyl phosphate as substrate at 10 uM after 30 mins relative to control | 2017 | Bioorganic & medicinal chemistry, 07-15, Volume: 25, Issue:14 | Screening for bioactive natural products from a 67-compound library of Glycyrrhiza inflata. |
| AID339162 | Antihyperlipidemic activity in Triton-induced hyperlipidemic rat model assessed as serum triglyceride level at 75 mg/kg, po administered for 2 days through gastric intubation immediately and 20 hrs after triton challenge measured after 4 hrs of last dose | 1993 | Journal of natural products, Jul, Volume: 56, Issue:7 | Antihyperlipidemic effect of flavonoids from Pterocarpus marsupium. |
| AID626905 | Inhibition of LPS-induced NF-kappaB p65 activation in human U937 cells at 5 ug/ml after 1 hr relative to control | 2011 | Journal of natural products, Sep-23, Volume: 74, Issue:9 | Comparative evaluation of two structurally related flavonoids, isoliquiritigenin and liquiritigenin, for their oral infection therapeutic potential. |
| AID339155 | Antihyperlipidemic activity in diet-induced hyperlipidemic rat model assessed as serum triglyceride level at 40 mg/kg, po administered once daily in morning through gastric intubation for 14 days measured after 4 hrs of last dose | 1993 | Journal of natural products, Jul, Volume: 56, Issue:7 | Antihyperlipidemic effect of flavonoids from Pterocarpus marsupium. |
| AID1347159 | Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 | Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1 | Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5 | A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347160 | Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 | Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5 | A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1346880 | Human Estrogen receptor-beta (3A. Estrogen receptors) | 2008 | Molecular and cellular endocrinology, Feb-13, Volume: 283, Issue:1-2 | Liquiritigenin is a plant-derived highly selective estrogen receptor beta agonist. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (2.42) | 18.2507 |
| 2000's | 43 (20.77) | 29.6817 |
| 2010's | 126 (60.87) | 24.3611 |
| 2020's | 33 (15.94) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.
| This Compound (37.03) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 6 (2.84%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 205 (97.16%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||