Proteins > Solute carrier organic anion transporter family member 1B3
Page last updated: 2024-08-08 00:17:20
Solute carrier organic anion transporter family member 1B3
A solute carrier organic anion transporter family member 1B3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NPD5]
Synonyms
Liver-specific organic anion transporter 2;
LST-2;
Organic anion transporter 8;
Organic anion-transporting polypeptide 8;
OATP-8;
Solute carrier family 21 member 8
Research
Bioassay Publications (22)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 10 (45.45) | 29.6817 |
| 2010's | 11 (50.00) | 24.3611 |
| 2020's | 1 (4.55) | 2.80 |
Compounds (79)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| microcystin yr | Homo sapiens (human) | EC50 | 0.0030 | 1 | 1 |
Drugs with Other Measurements
Structure-based identification of OATP1B1/3 inhibitors.Molecular pharmacology, , Volume: 83, Issue:6, 2013
Role of organic anion-transporting polypeptides, OATP-A, OATP-C and OATP-8, in the human placenta-maternal liver tandem excretory pathway for foetal bilirubin.The Biochemical journal, , May-01, Volume: 371, Issue:Pt 3, 2003
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.Journal of medicinal chemistry, , May-24, Volume: 55, Issue:10, 2012
Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide.The Journal of biological chemistry, , Jul-28, Volume: 275, Issue:30, 2000
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.Journal of medicinal chemistry, , May-24, Volume: 55, Issue:10, 2012
Interactions of rifamycin SV and rifampicin with organic anion uptake systems of human liver.Hepatology (Baltimore, Md.), , Volume: 36, Issue:1, 2002
Enables
This protein enables 4 target(s):
| Target | Category | Definition |
|---|
| serine-type endopeptidase inhibitor activity | molecular function | Binds to and stops, prevents or reduces the activity of a serine-type endopeptidase. [GOC:ai] |
| organic anion transmembrane transporter activity | molecular function | Enables the transfer of organic anions from one side of a membrane to the other. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage. [GOC:ai] |
| bile acid transmembrane transporter activity | molecular function | Enables the transfer of bile acid from one side of a membrane to the other. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine. [GOC:ai] |
| sodium-independent organic anion transmembrane transporter activity | molecular function | Enables the transfer of organic anions from one side of a membrane to the other, in a sodium independent manner. [GOC:go_curators] |
Located In
This protein is located in 2 target(s):
| Target | Category | Definition |
|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| basal plasma membrane | cellular component | The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. [GOC:go_curators] |
Active In
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|
| basolateral plasma membrane | cellular component | The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. [GOC:go_curators] |
Involved In
This protein is involved in 7 target(s):
| Target | Category | Definition |
|---|
| xenobiotic metabolic process | biological process | The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:cab2, GOC:krc] |
| monoatomic ion transport | biological process | The directed movement of a monoatomic ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic ions (also called simple ions) are ions consisting of exactly one atom. [GOC:ai] |
| organic anion transport | biological process | The directed movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage. [GOC:ai, GOC:krc] |
| bile acid and bile salt transport | biological process | The directed movement of bile acid and bile salts into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:dph, GOC:krc, PMID:12663868, PMID:14699511] |
| heme catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. [GOC:jl] |
| sodium-independent organic anion transport | biological process | The directed, sodium-independent, movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:go_curators] |
| transmembrane transport | biological process | The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. [GOC:dph, GOC:jid] |