Neuronal acetylcholine receptor subunit alpha-3

A neuronal acetylcholine receptor subunit alpha-3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P32297]

Synonyms

Research

Bioassay Publications (59)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	4 (6.78)	18.2507
2000's	20 (33.90)	29.6817
2010's	30 (50.85)	24.3611
2020's	5 (8.47)	2.80

Compounds (41)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
bupropion	Homo sapiens (human)	IC50	1.3670	6	6
3-(1-methylpyrrolidin-2-yl)pyridine	Homo sapiens (human)	Ki	0.0050	1	1
epibatidine	Homo sapiens (human)	Ki	0.0002	6	6
decamethonium	Homo sapiens (human)	IC50	1.7000	1	1
granisetron	Homo sapiens (human)	Ki	67.0000	1	1
mecamylamine	Homo sapiens (human)	IC50	1.6133	4	6
ondansetron	Homo sapiens (human)	IC50	27.0000	1	1
indopan	Homo sapiens (human)	Ki	10.0000	2	2
cytisine	Homo sapiens (human)	Ki	0.7664	7	7
anabaseine	Homo sapiens (human)	Ki	0.1070	1	1
polygodial	Homo sapiens (human)	IC50	48.2000	1	1
nicotine	Homo sapiens (human)	IC50	0.3899	4	4
nicotine	Homo sapiens (human)	Ki	0.3763	20	20
philanthotoxin 343	Homo sapiens (human)	IC50	0.0076	1	1
varenicline	Homo sapiens (human)	IC50	0.5550	2	2
varenicline	Homo sapiens (human)	Ki	0.0804	2	2
pozanicline	Homo sapiens (human)	Ki	10.0000	1	1
tropisetron	Homo sapiens (human)	IC50	1.8000	1	1
tropisetron	Homo sapiens (human)	Ki	16.0000	1	1
epibatidine	Homo sapiens (human)	Ki	0.0001	1	1
5-(6-chloro-3-pyridinyl)-9-azabicyclo[4.2.1]non-4-ene	Homo sapiens (human)	Ki	0.0065	1	1
trans-metanicotine	Homo sapiens (human)	Ki	5.4000	1	1
ar-r 17779	Homo sapiens (human)	IC50	1,000.0000	1	1
3-(2,4-dimethoxybenzylidene)anabaseine	Homo sapiens (human)	Ki	2.5000	2	2
mg 624	Homo sapiens (human)	Ki	0.4330	1	1
a 84543	Homo sapiens (human)	Ki	0.0077	1	1
radafaxine	Homo sapiens (human)	IC50	4.9000	2	2
pnu-282987	Homo sapiens (human)	IC50	60.0000	1	1
pnu-282987	Homo sapiens (human)	Ki	60.0000	1	1
ssr180711	Homo sapiens (human)	IC50	6.4800	1	1
desnitroimidacloprid	Homo sapiens (human)	IC50	0.0140	1	1
pnu-282987	Homo sapiens (human)	IC50	60.0000	1	1
3-bromocytisine	Homo sapiens (human)	IC50	0.0156	2	2
a-582941	Homo sapiens (human)	Ki	4.7000	1	1
n,n-diallyl-5-methoxytryptamine	Homo sapiens (human)	Ki	10.0000	2	2
imidacloprid	Homo sapiens (human)	IC50	14.0000	1	1
3-(4-hydroxy-2-methoxybenzylidene)anabaseine	Homo sapiens (human)	Ki	0.9700	2	2

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
epibatidine	Homo sapiens (human)	EC50	0.0158	6	7
epibatidine	Homo sapiens (human)	Kd	0.0002	2	2
dimethylphenylpiperazinium iodide	Homo sapiens (human)	EC50	56.0000	1	1
tilorone	Homo sapiens (human)	EC50	10.0000	2	2
cytisine	Homo sapiens (human)	EC50	46.5000	2	2
nicotine	Homo sapiens (human)	EC50	21.3260	14	15
3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole	Homo sapiens (human)	EC50	64.0000	1	1
varenicline	Homo sapiens (human)	EC50	1.5333	3	3
epibatidine	Homo sapiens (human)	Kd	0.0003	1	1
hmr 3647	Homo sapiens (human)	EC50	132.0000	1	1
abt 594	Homo sapiens (human)	EC50	0.1733	2	3
trans-metanicotine	Homo sapiens (human)	EC50	46.0000	1	1
a 85380	Homo sapiens (human)	EC50	0.7000	2	2
3-(2,4-dimethoxybenzylidene)anabaseine	Homo sapiens (human)	EC50	10.0000	1	1
a 84543	Homo sapiens (human)	EC50	19.4000	1	1
ispronicline	Homo sapiens (human)	EC50	10.0000	1	1
dianicline	Homo sapiens (human)	EC50	100.0000	1	1

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
3-(1-methylpyrrolidin-2-yl)pyridine	Homo sapiens (human)	ED50	14.0000	1	1
epibatidine	Homo sapiens (human)	Activity	0.0050	1	1
epibatidine	Homo sapiens (human)	ED50	0.0190	1	1
epibatidine	Homo sapiens (human)	INH	0.0003	1	1
cytisine	Homo sapiens (human)	Rmax	23.0000	1	1

Enables

This protein enables 5 target(s):

Target	Category	Definition
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
ligand-gated monoatomic ion channel activity	molecular function	Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. [GOC:mtg_transport, ISBN:0815340729]
acetylcholine receptor activity	molecular function	Combining with an acetylcholine receptor ligand and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:jl, GOC:signaling]
acetylcholine-gated monoatomic cation-selective channel activity	molecular function	Selectively enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine. [GOC:mah, PMID:2466967]
acetylcholine binding	molecular function	Binding to acetylcholine, an acetic acid ester of the organic base choline that functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions. [GOC:ai]

Located In

This protein is located in 10 target(s):

Target	Category	Definition
endoplasmic reticulum	cellular component	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732]
Golgi apparatus	cellular component	A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. [ISBN:0198506732]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
postsynaptic density	cellular component	An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. [GOC:BHF, GOC:dos, GOC:ef, GOC:jid, GOC:pr, GOC:sjp, http://molneuro.kaist.ac.kr/psd, PMID:14532281, Wikipedia:Postsynaptic_density]
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
nuclear speck	cellular component	A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy. [http://www.cellnucleus.com/]
dendrite	cellular component	A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]
neuronal cell body	cellular component	The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. [GOC:go_curators]
plasma membrane raft	cellular component	A membrane raft that is part of the plasma membrane. [GOC:jl]
postsynaptic membrane	cellular component	A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane. [ISBN:0198506732]

Active In

This protein is active in 3 target(s):

Target	Category	Definition
neuron projection	cellular component	A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. [GOC:jl, http://www.cogsci.princeton.edu/~wn/]
synapse	cellular component	The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Part Of

This protein is part of 1 target(s):

Target	Category	Definition
acetylcholine-gated channel complex	cellular component	A homo- or hetero-pentameric protein complex that forms a transmembrane channel through which ions may pass in response to acetylcholine binding. [GOC:bf, GOC:mah, PMID:12381728, PMID:15579462]

Involved In

This protein is involved in 18 target(s):

Target	Category	Definition
monoatomic ion transport	biological process	The directed movement of a monoatomic ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic ions (also called simple ions) are ions consisting of exactly one atom. [GOC:ai]
regulation of smooth muscle contraction	biological process	Any process that modulates the frequency, rate or extent of smooth muscle contraction. [GOC:go_curators]
signal transduction	biological process	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. [GOC:go_curators, GOC:mtg_signaling_feb11]
activation of transmembrane receptor protein tyrosine kinase activity	biological process	Any process that initiates the activity of the inactive transmembrane receptor protein tyrosine kinase activity. [GOC:dph, GOC:tb]
synaptic transmission, cholinergic	biological process	The vesicular release of acetylcholine from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. [GOC:dos, Wikipedia:Cholinergic]
nervous system development	biological process	The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state. [GOC:dgh]
locomotory behavior	biological process	The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions. [GOC:dph]
regulation of acetylcholine secretion, neurotransmission	biological process	Any process that modulates the frequency, rate or extent of the regulated release of acetylcholine. [GOC:ef]
monoatomic ion transmembrane transport	biological process	A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom. [GOC:mah]
behavioral response to nicotine	biological process	Any process that results in a change in the behavior of an organism as a result of a nicotine stimulus. [GOC:bf, ISBN:0198506732]
regulation of membrane potential	biological process	Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. [GOC:jl, GOC:mtg_cardio, GOC:tb, ISBN:0198506732]
regulation of dendrite morphogenesis	biological process	Any process that modulates the frequency, rate or extent of dendrite morphogenesis. [GOC:ai]
excitatory postsynaptic potential	biological process	A process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential. [GOC:dph, GOC:ef]
synaptic transmission involved in micturition	biological process	The process of communication from a neuron to a smooth muscle in the bladder that contributes to the expulsion of urine from the body. [GOC:dph, PMID:15827347]
acetylcholine receptor signaling pathway	biological process	The series of molecular signals generated as a consequence of an acetylcholine receptor binding to one of its physiological ligands. [GOC:mah]
response to acetylcholine	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetylcholine stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:21238497]
response to nicotine	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus. [GOC:bf, GOC:ef, ISBN:0198506732, ISBN:0582227089]
membrane depolarization	biological process	The process in which membrane potential decreases with respect to its steady-state potential, usually from negative potential to a more positive potential. For example, the initial depolarization during the rising phase of an action potential is in the direction from the negative steady-state resting potential towards the positive membrane potential that will be the peak of the action potential. [GOC:dh, Wikipedia:Depolarization]