Proteins > Angiotensin-converting enzyme
Page last updated: 2024-08-07 15:57:05
Angiotensin-converting enzyme
[no definition available]
Synonyms
ACE;
EC 3.2.1.-;
EC 3.4.15.1;
Dipeptidyl carboxypeptidase I;
Kininase II
Research
Bioassay Publications (34)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 12 (35.29) | 18.7374 |
| 1990's | 12 (35.29) | 18.2507 |
| 2000's | 3 (8.82) | 29.6817 |
| 2010's | 7 (20.59) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (76)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| amitriptyline | Oryctolagus cuniculus (rabbit) | IC50 | 17.5894 | 1 | 0 |
| amitriptyline | Oryctolagus cuniculus (rabbit) | Ki | 14.4106 | 1 | 0 |
| carvedilol | Oryctolagus cuniculus (rabbit) | IC50 | 4.1193 | 1 | 0 |
| carvedilol | Oryctolagus cuniculus (rabbit) | Ki | 3.3749 | 1 | 0 |
| chlorpromazine | Oryctolagus cuniculus (rabbit) | IC50 | 5.8275 | 1 | 0 |
| chlorpromazine | Oryctolagus cuniculus (rabbit) | Ki | 4.7743 | 1 | 0 |
| cisapride | Oryctolagus cuniculus (rabbit) | IC50 | 0.1701 | 1 | 0 |
| cisapride | Oryctolagus cuniculus (rabbit) | Ki | 0.1394 | 1 | 0 |
| citalopram | Oryctolagus cuniculus (rabbit) | IC50 | 16.6754 | 1 | 0 |
| citalopram | Oryctolagus cuniculus (rabbit) | Ki | 13.6618 | 1 | 0 |
| cyproheptadine | Oryctolagus cuniculus (rabbit) | IC50 | 17.0491 | 1 | 0 |
| cyproheptadine | Oryctolagus cuniculus (rabbit) | Ki | 13.9679 | 1 | 0 |
| desipramine | Oryctolagus cuniculus (rabbit) | IC50 | 27.8497 | 1 | 0 |
| desipramine | Oryctolagus cuniculus (rabbit) | Ki | 22.8166 | 1 | 0 |
| dicyclomine | Oryctolagus cuniculus (rabbit) | IC50 | 20.5909 | 1 | 0 |
| dicyclomine | Oryctolagus cuniculus (rabbit) | Ki | 16.8697 | 1 | 0 |
| diphenhydramine | Oryctolagus cuniculus (rabbit) | IC50 | 31.8590 | 1 | 0 |
| diphenhydramine | Oryctolagus cuniculus (rabbit) | Ki | 26.1013 | 1 | 0 |
| thiorphan | Oryctolagus cuniculus (rabbit) | IC50 | 0.4200 | 1 | 3 |
| doxazosin | Oryctolagus cuniculus (rabbit) | IC50 | 2.2155 | 1 | 0 |
| doxazosin | Oryctolagus cuniculus (rabbit) | Ki | 1.8151 | 1 | 0 |
| droperidol | Oryctolagus cuniculus (rabbit) | IC50 | 0.9272 | 1 | 0 |
| droperidol | Oryctolagus cuniculus (rabbit) | Ki | 0.7596 | 1 | 0 |
| ebastine | Oryctolagus cuniculus (rabbit) | IC50 | 0.1048 | 1 | 0 |
| ebastine | Oryctolagus cuniculus (rabbit) | Ki | 0.0858 | 1 | 0 |
| flavoxate | Oryctolagus cuniculus (rabbit) | IC50 | 24.1069 | 1 | 0 |
| flavoxate | Oryctolagus cuniculus (rabbit) | Ki | 19.7503 | 1 | 0 |
| fluphenazine | Oryctolagus cuniculus (rabbit) | IC50 | 5.7058 | 1 | 0 |
| fluphenazine | Oryctolagus cuniculus (rabbit) | Ki | 4.6746 | 1 | 0 |
| fluoxetine | Oryctolagus cuniculus (rabbit) | IC50 | 12.2864 | 1 | 0 |
| fluoxetine | Oryctolagus cuniculus (rabbit) | Ki | 10.0660 | 1 | 0 |
| haloperidol | Oryctolagus cuniculus (rabbit) | IC50 | 7.0000 | 1 | 1 |
| loratadine | Oryctolagus cuniculus (rabbit) | IC50 | 39.0866 | 1 | 0 |
| loratadine | Oryctolagus cuniculus (rabbit) | Ki | 32.0228 | 1 | 0 |
| methiothepin | Oryctolagus cuniculus (rabbit) | Ki | 0.0022 | 1 | 2 |
| mitoxantrone | Oryctolagus cuniculus (rabbit) | IC50 | 3.5849 | 1 | 0 |
| mitoxantrone | Oryctolagus cuniculus (rabbit) | Ki | 2.9370 | 1 | 0 |
| pentamidine | Oryctolagus cuniculus (rabbit) | IC50 | 15.7215 | 1 | 0 |
| pentamidine | Oryctolagus cuniculus (rabbit) | Ki | 12.8802 | 1 | 0 |
| perphenazine | Oryctolagus cuniculus (rabbit) | IC50 | 4.2160 | 1 | 0 |
| perphenazine | Oryctolagus cuniculus (rabbit) | Ki | 3.4541 | 1 | 0 |
| prazosin | Oryctolagus cuniculus (rabbit) | IC50 | 24.2778 | 1 | 0 |
| prazosin | Oryctolagus cuniculus (rabbit) | Ki | 7.8301 | 2 | 2 |
| prochlorperazine | Oryctolagus cuniculus (rabbit) | IC50 | 1.8481 | 1 | 0 |
| prochlorperazine | Oryctolagus cuniculus (rabbit) | Ki | 1.5141 | 1 | 0 |
| pyrilamine | Oryctolagus cuniculus (rabbit) | IC50 | 12.6182 | 1 | 0 |
| pyrilamine | Oryctolagus cuniculus (rabbit) | Ki | 10.3378 | 1 | 0 |
| risperidone | Oryctolagus cuniculus (rabbit) | IC50 | 4.1901 | 1 | 0 |
| risperidone | Oryctolagus cuniculus (rabbit) | Ki | 3.4328 | 1 | 0 |
| thioridazine | Oryctolagus cuniculus (rabbit) | IC50 | 1.5880 | 1 | 0 |
| thioridazine | Oryctolagus cuniculus (rabbit) | Ki | 1.3010 | 1 | 0 |
| tiopronin | Oryctolagus cuniculus (rabbit) | IC50 | 1.9000 | 2 | 2 |
| trifluoperazine | Oryctolagus cuniculus (rabbit) | IC50 | 6.2260 | 1 | 0 |
| trifluoperazine | Oryctolagus cuniculus (rabbit) | Ki | 5.1008 | 1 | 0 |
| phentolamine | Oryctolagus cuniculus (rabbit) | IC50 | 20.0763 | 1 | 0 |
| phentolamine | Oryctolagus cuniculus (rabbit) | Ki | 16.4480 | 1 | 0 |
| benzethonium chloride | Oryctolagus cuniculus (rabbit) | IC50 | 0.1085 | 1 | 0 |
| benzethonium chloride | Oryctolagus cuniculus (rabbit) | Ki | 0.0889 | 1 | 0 |
| clemastine | Oryctolagus cuniculus (rabbit) | IC50 | 0.3951 | 1 | 0 |
| clemastine | Oryctolagus cuniculus (rabbit) | Ki | 0.3237 | 1 | 0 |
| paroxetine | Oryctolagus cuniculus (rabbit) | IC50 | 10.4293 | 1 | 0 |
| paroxetine | Oryctolagus cuniculus (rabbit) | Ki | 8.5445 | 1 | 0 |
| captopril | Oryctolagus cuniculus (rabbit) | IC50 | 0.0173 | 10 | 16 |
| captopril | Oryctolagus cuniculus (rabbit) | Ki | 0.0017 | 1 | 1 |
| quinapril | Oryctolagus cuniculus (rabbit) | IC50 | 0.1100 | 1 | 1 |
| sertindole | Oryctolagus cuniculus (rabbit) | Ki | 0.0330 | 1 | 2 |
| sparfloxacin | Oryctolagus cuniculus (rabbit) | IC50 | 47.1384 | 1 | 0 |
| sparfloxacin | Oryctolagus cuniculus (rabbit) | Ki | 38.6194 | 1 | 0 |
| fosinoprilat | Oryctolagus cuniculus (rabbit) | Ki | 0.0015 | 1 | 1 |
| sertraline | Oryctolagus cuniculus (rabbit) | IC50 | 8.3173 | 1 | 0 |
| sertraline | Oryctolagus cuniculus (rabbit) | Ki | 6.8141 | 1 | 0 |
| leucyltyrosine | Oryctolagus cuniculus (rabbit) | IC50 | 44.0000 | 1 | 1 |
| alanylproline | Oryctolagus cuniculus (rabbit) | IC50 | 270.0000 | 1 | 1 |
| alanylproline | Oryctolagus cuniculus (rabbit) | Ki | 40.0000 | 2 | 2 |
| glycylaspartic acid | Oryctolagus cuniculus (rabbit) | IC50 | 9,200.0000 | 1 | 1 |
| n-glycylglutamic acid | Oryctolagus cuniculus (rabbit) | IC50 | 5,400.0000 | 1 | 1 |
| 3-(mercaptomethyl)-2-oxo-1-piperidineacetic acid | Oryctolagus cuniculus (rabbit) | IC50 | 3.5286 | 2 | 7 |
| compound 20 | Oryctolagus cuniculus (rabbit) | Ki | 1.8000 | 1 | 1 |
| ceronapril | Oryctolagus cuniculus (rabbit) | IC50 | 0.0360 | 1 | 1 |
| temocaprilat | Oryctolagus cuniculus (rabbit) | IC50 | 0.0036 | 1 | 1 |
| omapatrilat | Oryctolagus cuniculus (rabbit) | IC50 | 0.0053 | 3 | 3 |
| flunarizine | Oryctolagus cuniculus (rabbit) | IC50 | 0.6058 | 1 | 0 |
| flunarizine | Oryctolagus cuniculus (rabbit) | Ki | 0.4963 | 1 | 0 |
| tamoxifen | Oryctolagus cuniculus (rabbit) | IC50 | 0.9670 | 1 | 0 |
| tamoxifen | Oryctolagus cuniculus (rabbit) | Ki | 0.7922 | 1 | 0 |
| zofenoprilate | Oryctolagus cuniculus (rabbit) | Ki | 0.0004 | 1 | 1 |
| glycyllysine | Oryctolagus cuniculus (rabbit) | IC50 | 5,400.0000 | 1 | 1 |
| quercetin 3-o-glucuronide | Oryctolagus cuniculus (rabbit) | IC50 | 200.0000 | 2 | 2 |
| apigenin | Oryctolagus cuniculus (rabbit) | IC50 | 140,140.0000 | 2 | 2 |
| luteolin | Oryctolagus cuniculus (rabbit) | IC50 | 290.0000 | 2 | 2 |
| luteolin-7-glucoside | Oryctolagus cuniculus (rabbit) | IC50 | 280.0000 | 1 | 1 |
| butein | Oryctolagus cuniculus (rabbit) | IC50 | 243,576.9100 | 3 | 3 |
| kaempferol-3-o-galactoside | Oryctolagus cuniculus (rabbit) | IC50 | 260.0000 | 2 | 2 |
| lisinopril | Oryctolagus cuniculus (rabbit) | IC50 | 0.2870 | 3 | 3 |
| lisinopril | Oryctolagus cuniculus (rabbit) | Ki | 0.0510 | 1 | 1 |
| benazepril | Oryctolagus cuniculus (rabbit) | IC50 | 0.1047 | 3 | 3 |
| ramipril | Oryctolagus cuniculus (rabbit) | IC50 | 0.2530 | 2 | 2 |
| enalapril | Oryctolagus cuniculus (rabbit) | IC50 | 2.7083 | 3 | 3 |
| enalaprilat anhydrous | Oryctolagus cuniculus (rabbit) | IC50 | 0.0054 | 4 | 5 |
| enalaprilat anhydrous | Oryctolagus cuniculus (rabbit) | Ki | 0.0014 | 1 | 1 |
| benazeprilat | Oryctolagus cuniculus (rabbit) | IC50 | 0.0020 | 1 | 1 |
| pepstatin | Oryctolagus cuniculus (rabbit) | IC50 | 100.0000 | 1 | 2 |
| uk 81,252 | Oryctolagus cuniculus (rabbit) | IC50 | 0.0070 | 1 | 1 |
| rhc 3659 | Oryctolagus cuniculus (rabbit) | IC50 | 3.6000 | 1 | 1 |
| alanylglycine | Oryctolagus cuniculus (rabbit) | IC50 | 2,500.0000 | 1 | 1 |
| valyltyrosine | Oryctolagus cuniculus (rabbit) | IC50 | 7.0000 | 1 | 1 |
| phenylalanylproline | Oryctolagus cuniculus (rabbit) | IC50 | 210.0000 | 1 | 1 |
| isoleucyl-tyrosine | Oryctolagus cuniculus (rabbit) | IC50 | 3.7000 | 1 | 1 |
| valyl-prolyl-proline | Oryctolagus cuniculus (rabbit) | IC50 | 9.0000 | 1 | 1 |
| prolylvaline | Oryctolagus cuniculus (rabbit) | IC50 | 420.0000 | 1 | 1 |
| 3-hydroxy-4,3',4',5'-tetramethoxychalcone | Oryctolagus cuniculus (rabbit) | IC50 | 225.0000 | 1 | 1 |
| clozapine | Oryctolagus cuniculus (rabbit) | IC50 | 6.2855 | 2 | 1 |
| clozapine | Oryctolagus cuniculus (rabbit) | Ki | 8.6606 | 1 | 0 |
| olanzapine | Oryctolagus cuniculus (rabbit) | IC50 | 100.0000 | 1 | 0 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| captopril | Oryctolagus cuniculus (rabbit) | Inhibition | 0.0027 | 1 | 1 |
Angiotensin-converting enzyme inhibitors: new orally active 1,4-thiazepine-2,5-diones, 1,4-thiazine-2,5-diones, and 1,4-benzothiazepine-2,5-diones possessing antihypertensive activity.Journal of medicinal chemistry, , Volume: 29, Issue:5, 1986
Angiotensin-converting enzyme inhibitors. New orally active antihypertensive (mercaptoalkanoyl)- and [(acylthio)alkanoyl]glycine derivatives.Journal of medicinal chemistry, , Volume: 28, Issue:1, 1985
Probing the importance of spacial and conformational domains in captopril analogs for angiotensin converting enzyme activity.Bioorganic & medicinal chemistry letters, , Aug-18, Volume: 8, Issue:16, 1998
New alpha-thiol dipeptide dual inhibitors of angiotensin-I converting enzyme and neutral endopeptidase EC 3.4.24.11.Journal of medicinal chemistry, , Dec-22, Volume: 38, Issue:26, 1995
(R)-2-(3-mercapto-2(S)-methyl-1-oxo-propoxy)-3-(methylthio)propanoic acid, the first ultra-short-acting angiotensin converting enzyme inhibitor.Journal of medicinal chemistry, , Oct-02, Volume: 35, Issue:20, 1992
Synthesis and pharmacological activity of angiotensin converting enzyme inhibitors: N-(mercaptoacyl)-4-substituted-(S)-prolines.Journal of medicinal chemistry, , Volume: 31, Issue:4, 1988
Angiotensin-converting enzyme inhibitors. Mercaptan, carboxyalkyl dipeptide, and phosphinic acid inhibitors incorporating 4-substituted prolines.Journal of medicinal chemistry, , Volume: 31, Issue:6, 1988
Angiotensin-converting enzyme inhibitors. New orally active antihypertensive (mercaptoalkanoyl)- and [(acylthio)alkanoyl]glycine derivatives.Journal of medicinal chemistry, , Volume: 28, Issue:1, 1985
Angiotensin converting enzyme inhibitors. (Mercaptoaroyl)amino acids.Journal of medicinal chemistry, , Volume: 28, Issue:3, 1985
Bicyclic lactam inhibitors of angiotensin converting enzyme.Journal of medicinal chemistry, , Volume: 27, Issue:6, 1984
Angiotensin converting enzyme inhibitors: 1-glutarylindoline-2-carboxylic acids derivatives.Journal of medicinal chemistry, , Volume: 26, Issue:9, 1983
Angiotensin converting enzyme inhibitors: N-substituted monocyclic and bicyclic amino acid derivatives.Journal of medicinal chemistry, , Volume: 26, Issue:9, 1983
Angiotensin-converting enzyme inhibitors: importance of the amide carbonyl of mercaptoacyl amino acids for hydrogen bonding to the enzyme.Journal of medicinal chemistry, , Volume: 25, Issue:3, 1982
Angiotensin-I-converting enzyme inhibitory peptides: Chemical feature based pharmacophore generation.European journal of medicinal chemistry, , Volume: 46, Issue:8, 2011
N alpha-(diphenoxyphosphoryl)-L-alanyl-L-proline, N alpha-[bis (4-nitrophenoxy)phosphoryl]-L-alanyl-L-proline, and N alpha-[ (2-phenylethyl)phenoxyphosphoryl]-L-alanyl-L-proline: releasers of potent inhibitors of angiotensin converting enzyme at physiologJournal of medicinal chemistry, , Volume: 28, Issue:10, 1985
N-formyl hydroxylamine containing dipeptides: generation of a new class of vasopeptidase inhibitors.Bioorganic & medicinal chemistry letters, , Feb-07, Volume: 10, Issue:3, 2000
Vasopeptidase inhibitors: incorporation of geminal and spirocyclic substituted azepinones in mercaptoacyl dipeptides.Journal of medicinal chemistry, , Jan-28, Volume: 42, Issue:2, 1999
Dual metalloprotease inhibitors: mercaptoacetyl-based fused heterocyclic dipeptide mimetics as inhibitors of angiotensin-converting enzyme and neutral endopeptidase.Journal of medicinal chemistry, , May-23, Volume: 40, Issue:11, 1997
Synthesis and evaluation of novel 2-butyl-4-chloro-1-methylimidazole embedded chalcones and pyrazoles as angiotensin converting enzyme (ACE) inhibitors.Bioorganic & medicinal chemistry, , Aug-15, Volume: 19, Issue:16, 2011
The synthesis and angiotensin converting enzyme (ACE) inhibitory activity of chalcones and their pyrazole derivatives.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 20, Issue:6, 2010
Synthesis and evaluation of novel 2-butyl-4-chloro-1-methylimidazole embedded chalcones and pyrazoles as angiotensin converting enzyme (ACE) inhibitors.Bioorganic & medicinal chemistry, , Aug-15, Volume: 19, Issue:16, 2011
The synthesis and angiotensin converting enzyme (ACE) inhibitory activity of chalcones and their pyrazole derivatives.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 20, Issue:6, 2010
Synthesis and evaluation of novel 2-butyl-4-chloro-1-methylimidazole embedded chalcones and pyrazoles as angiotensin converting enzyme (ACE) inhibitors.Bioorganic & medicinal chemistry, , Aug-15, Volume: 19, Issue:16, 2011
The synthesis and angiotensin converting enzyme (ACE) inhibitory activity of chalcones and their pyrazole derivatives.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 20, Issue:6, 2010
Design and green synthesis of 2-(diarylalkyl)aminobenzothiazole derivatives and their dual activities as angiotensin converting enzyme inhibitors and calcium channel blockers.European journal of medicinal chemistry, , Aug-18, Volume: 83, 2014
Synthesis and evaluation of novel 2-butyl-4-chloro-1-methylimidazole embedded chalcones and pyrazoles as angiotensin converting enzyme (ACE) inhibitors.Bioorganic & medicinal chemistry, , Aug-15, Volume: 19, Issue:16, 2011
The synthesis and angiotensin converting enzyme (ACE) inhibitory activity of chalcones and their pyrazole derivatives.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 20, Issue:6, 2010
Synthesis and evaluation of novel 2-butyl-4-chloro-1-methylimidazole embedded chalcones and pyrazoles as angiotensin converting enzyme (ACE) inhibitors.Bioorganic & medicinal chemistry, , Aug-15, Volume: 19, Issue:16, 2011
The synthesis and angiotensin converting enzyme (ACE) inhibitory activity of chalcones and their pyrazole derivatives.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 20, Issue:6, 2010
Design, synthesis and evaluation of novel 2-butyl-4-chloroimidazole derived peptidomimetics as Angiotensin Converting Enzyme (ACE) inhibitors.Bioorganic & medicinal chemistry, , Jul-01, Volume: 23, Issue:13, 2015
Synthesis and evaluation of novel triazoles and mannich bases functionalized 1,4-dihydropyridine as angiotensin converting enzyme (ACE) inhibitors.Bioorganic & medicinal chemistry, , Nov-01, Volume: 22, Issue:21, 2014
Design, synthesis and evaluation of novel 2-hydroxypyrrolobenzodiazepine-5,11-dione analogues as potent angiotensin converting enzyme (ACE) inhibitors.Bioorganic & medicinal chemistry, , Aug-01, Volume: 21, Issue:15, 2013
Synthesis of novel keto-ACE analogues as domain-selective angiotensin I-converting enzyme inhibitors.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 16, Issue:17, 2006
Design, synthesis and evaluation of novel 2-butyl-4-chloroimidazole derived peptidomimetics as Angiotensin Converting Enzyme (ACE) inhibitors.Bioorganic & medicinal chemistry, , Jul-01, Volume: 23, Issue:13, 2015
Design, synthesis and evaluation of novel 2-hydroxypyrrolobenzodiazepine-5,11-dione analogues as potent angiotensin converting enzyme (ACE) inhibitors.Bioorganic & medicinal chemistry, , Aug-01, Volume: 21, Issue:15, 2013
Dual angiotensin converting enzyme/thromboxane synthase inhibitors.Journal of medicinal chemistry, , Jun-10, Volume: 37, Issue:12, 1994
Design, synthesis and evaluation of novel 2-butyl-4-chloroimidazole derived peptidomimetics as Angiotensin Converting Enzyme (ACE) inhibitors.Bioorganic & medicinal chemistry, , Jul-01, Volume: 23, Issue:13, 2015
Design, synthesis and evaluation of novel 2-hydroxypyrrolobenzodiazepine-5,11-dione analogues as potent angiotensin converting enzyme (ACE) inhibitors.Bioorganic & medicinal chemistry, , Aug-01, Volume: 21, Issue:15, 2013
Design, synthesis and evaluation of novel 2-butyl-4-chloroimidazole derived peptidomimetics as Angiotensin Converting Enzyme (ACE) inhibitors.Bioorganic & medicinal chemistry, , Jul-01, Volume: 23, Issue:13, 2015
Dual angiotensin converting enzyme/thromboxane synthase inhibitors.Journal of medicinal chemistry, , Jun-10, Volume: 37, Issue:12, 1994
Angiotensin-converting enzyme inhibitors. New orally active antihypertensive (mercaptoalkanoyl)- and [(acylthio)alkanoyl]glycine derivatives.Journal of medicinal chemistry, , Volume: 28, Issue:1, 1985
New alpha-thiol dipeptide dual inhibitors of angiotensin-I converting enzyme and neutral endopeptidase EC 3.4.24.11.Journal of medicinal chemistry, , Dec-22, Volume: 38, Issue:26, 1995
Configuration and preferential solid-state conformations of perindoprilat (S-9780). Comparison with the crystal structures of other ACE inhibitors and conclusions related to structure-activity relationships.Journal of medicinal chemistry, , Volume: 34, Issue:2, 1991
Angiotensin-converting enzyme inhibitors. Mercaptan, carboxyalkyl dipeptide, and phosphinic acid inhibitors incorporating 4-substituted prolines.Journal of medicinal chemistry, , Volume: 31, Issue:6, 1988
Angiotensin-converting enzyme inhibitors. 2. Perhydroazepin-2-one derivatives.Journal of medicinal chemistry, , Volume: 31, Issue:2, 1988
Angiotensin-converting enzyme inhibitors: perhydro-1,4-thiazepin-5-one derivatives.Journal of medicinal chemistry, , Volume: 30, Issue:11, 1987