Page last updated: 2024-10-25

diazepam and Necrosis

diazepam has been researched along with Necrosis in 21 studies

Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.

Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.

Research Excerpts

ExcerptRelevanceReference
" The present study was undertaken to determine whether diazepam, a potent, centrally penetrating GABAmimetic, alone or in combination with insulin, could mitigate postischemic seizures or regional selective neuronal necrosis and infarction."7.68Postischemic seizures and necrotizing ischemic brain damage: neuroprotective effect of postischemic diazepam and insulin. ( Auer, RN; Voll, CL, 1991)
"Acute fulminant hepatic necrosis was associated with repeated oral administration of diazepam (1."3.69Fulminant hepatic failure associated with oral administration of diazepam in 11 cats. ( Bank, S; Brunt, JE; Center, SA; Dring, LA; Elston, TH; House, J; Levy, JK; Lynch, LR; Reitz, BL; Rodan, I; Rosen, DK; Rowland, PH, 1996)
" The present study was undertaken to determine whether diazepam, a potent, centrally penetrating GABAmimetic, alone or in combination with insulin, could mitigate postischemic seizures or regional selective neuronal necrosis and infarction."3.68Postischemic seizures and necrotizing ischemic brain damage: neuroprotective effect of postischemic diazepam and insulin. ( Auer, RN; Voll, CL, 1991)
"The significant occurrence of thrombophlebitis in patients administered diazepam intravenously was described recently."3.66Poloxamer 188 as vehicle for injectable diazepam. ( Bernardoni, RJ; Ecanow, B; Prancan, AV; Sadove, MS, 1980)

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-199014 (66.67)18.7374
1990's4 (19.05)18.2507
2000's0 (0.00)29.6817
2010's3 (14.29)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Yu, L1
Zhou, Y1
Wang, Y1
Ohno, S1
Kobayashi, K1
Uchida, S1
Amano, O1
Sakagami, H1
Nagasaka, H1
Ukley, B1
Hermann, W1
Ratcliffe, HL2
Snyder, RL1
Mikhaĭlenko, AA1
Beliakov, VA1
Sinitsyn, LN1
Kolpashchikova, IF1
Shidlovskiĭ, AS1
Prancan, AV1
Ecanow, B1
Bernardoni, RJ1
Sadove, MS1
Center, SA1
Elston, TH1
Rowland, PH1
Rosen, DK1
Reitz, BL1
Brunt, JE1
Rodan, I1
House, J1
Bank, S1
Lynch, LR1
Dring, LA1
Levy, JK1
Joist, A1
Tibesku, CO1
Neuber, M1
Frerichmann, U1
Joosten, U1
Varma, AJ1
Fisher, BK1
Sarin, MK1
Steiness, E2
Rasmussen, F2
Svendsen, O2
Nielsen, P1
Ben-Ari, Y1
Lagowska, Y1
Le Gal La Salle, G1
Tremblay, E1
Ottersen, OP1
Naquet, R1
Larsen, JP1
Tassinari, CA1
Roger, J1
Dravat, C1
Gustaut, H1
Voll, CL1
Auer, RN1
Hayward, IJ1
Wall, HG1
Jaax, NK1
Wade, JV1
Marlow, DD1
Nold, JB1
Williams, R1
Grivaux, M1
Soulié, J1
Diallo, A1
Renard, C1
Chevalley, J1
Guaitani, A1
Marcucci, F1
Garattini, S1
Detweiler, DK1
Luginbühl, H1
Jorgensen, F1
Ulff-Moller, B1

Reviews

1 review available for diazepam and Necrosis

ArticleYear
Problems of fulminant hepatic failure.
    British medical bulletin, 1972, Volume: 28, Issue:2

    Topics: Acute Disease; Adrenal Cortex Hormones; Amylases; Brain Diseases; Brain Stem; Diazepam; Dihydroxyphe

1972

Other Studies

20 other studies available for diazepam and Necrosis

ArticleYear
Effect of mild hypothermia on glutamate receptor expression after status epilepticus.
    Epilepsy research, 2012, Volume: 101, Issue:1-2

    Topics: Animals; Apoptosis; Blotting, Western; Cell Count; Diazepam; Electrodes, Implanted; Electroencephalo

2012
Cytotoxicity and type of cell death induced by midazolam in human oral normal and tumor cells.
    Anticancer research, 2012, Volume: 32, Issue:11

    Topics: Anesthetics, Intravenous; Carcinoma, Squamous Cell; Cell Death; Cell Line, Tumor; Diazepam; DNA Frag

2012
[Subacute Parkinson's disease after suicide attempt with diazepam].
    Der Nervenarzt, 2013, Volume: 84, Issue:2

    Topics: Adult; Antiparkinson Agents; Cerebellum; Diazepam; Disease Progression; Drug Overdose; Follow-Up Stu

2013
Arteriosclerotic stenosis of the intramural coronary arteries of chickens: further evidence of a relation to social factors.
    British journal of experimental pathology, 1967, Volume: 48, Issue:3

    Topics: Animals; Arteriosclerosis; Behavior, Animal; Coronary Disease; Diazepam; Female; Male; Myocardium; N

1967
[Use of sodium oxybutyrate and diazepam for removing the psychomotor excitation in hepatic coma].
    Anesteziologiia i reanimatologiia, 1980, Issue:4

    Topics: Animals; Carbon Tetrachloride Poisoning; Cats; Diazepam; Drug Evaluation; Drug Evaluation, Preclinic

1980
Poloxamer 188 as vehicle for injectable diazepam.
    Journal of pharmaceutical sciences, 1980, Volume: 69, Issue:8

    Topics: Animals; Diazepam; Injections; Male; Necrosis; Pharmaceutical Vehicles; Poloxalene; Polyethylene Gly

1980
Fulminant hepatic failure associated with oral administration of diazepam in 11 cats.
    Journal of the American Veterinary Medical Association, 1996, Aug-01, Volume: 209, Issue:3

    Topics: Animals; Anti-Anxiety Agents; Cat Diseases; Cats; Diazepam; Female; Hepatic Encephalopathy; Liver; M

1996
[Gangrene of the fingers caused by accidental intra-arterial injection of diazepam].
    Deutsche medizinische Wochenschrift (1946), 1999, Jun-18, Volume: 124, Issue:24

    Topics: Amputation, Surgical; Angiography; Anti-Anxiety Agents; Arterial Occlusive Diseases; Diagnosis, Diff

1999
Diazepam-induced coma with bullae and eccrine sweat gland necrosis.
    Archives of internal medicine, 1977, Volume: 137, Issue:9

    Topics: Adult; Coma; Diazepam; Humans; Male; Necrosis; Skin Diseases, Vesiculobullous; Substance-Related Dis

1977
A comparative study of serum creatine phosphokinase (CPK) activity in rabbits, pigs and humans after intramuscular injection of local damaging drugs.
    Acta pharmacologica et toxicologica, 1978, Volume: 42, Issue:5

    Topics: Animals; Creatine Kinase; Diazepam; Digoxin; Female; Humans; Injections, Intramuscular; Lidocaine; M

1978
Diazepam pretreatment reduces distant hippocampal damage induced by intra-amygdaloid injections of kainic acid.
    European journal of pharmacology, 1978, Dec-01, Volume: 52, Issue:3-4

    Topics: Amygdala; Animals; Convulsants; Diazepam; Hippocampus; Injections; Kainic Acid; Male; Necrosis; Pyrr

1978
[Necrosis of a finger after radial artery cannulation].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1977, May-10, Volume: 97, Issue:13

    Topics: Adult; Aged; Arm; Arteries; Blood Coagulation Disorders; Catheterization; Diazepam; Fingers; Gangren

1977
[Local necrosis following intramuscular injection].
    Ugeskrift for laeger, 1976, Nov-22, Volume: 138, Issue:48

    Topics: Animals; Creatine Kinase; Diazepam; Humans; Injections, Intramuscular; Isotonic Solutions; Lidocaine

1976
Letter: Comments on a startling article: "loss of limb following intravenous diazepam".
    Pediatrics, 1975, Volume: 55, Issue:6

    Topics: Amputation, Surgical; Arm; Benzodiazepines; Diazepam; Epilepsy; Humans; Injections, Intra-Arterial;

1975
Postischemic seizures and necrotizing ischemic brain damage: neuroprotective effect of postischemic diazepam and insulin.
    Neurology, 1991, Volume: 41, Issue:3

    Topics: Animals; Brain Damage, Chronic; Brain Ischemia; Diazepam; Insulin; Male; Necrosis; Nervous System; R

1991
Decreased brain pathology in organophosphate-exposed rhesus monkeys following benzodiazepine therapy.
    Journal of the neurological sciences, 1990, Volume: 98, Issue:1

    Topics: Animals; Brain; Diazepam; Macaca mulatta; Male; Midazolam; Necrosis; Neurons; Soman

1990
[Therapeutic hyperosmolarity].
    Annales de medecine interne, 1973, Volume: 124, Issue:3

    Topics: Adult; Bicarbonates; Blood Transfusion; Brain Diseases; Chemical and Drug Induced Liver Injury; Diaz

1973
Increased aggression and toxicity in grouped male mice treated with tranquilizing benzodiazepines.
    Psychopharmacologia, 1971, Volume: 19, Issue:3

    Topics: Aggression; Animals; Behavior, Animal; Diazepam; Dibenzazepines; Female; Humans; Male; Methylation;

1971
The significance of naturally occurring coronary and cerebral arterial disease in animals.
    Annals of the New York Academy of Sciences, 1968, Nov-21, Volume: 149, Issue:2

    Topics: Analysis of Variance; Animals; Animals, Zoo; Basal Ganglia; Brain; Carnivora; Cerebral Arterial Dise

1968
[Abuse of hypnotics and sedatives by young addicts].
    Ugeskrift for laeger, 1971, Jul-30, Volume: 133, Issue:30

    Topics: Adolescent; Adult; Barbiturates; Diazepam; Female; Humans; Hypnotics and Sedatives; Morphine; Necros

1971