| Substance | Relationship Strength | Studies | Trials | Classes | Roles |
|---|
xanthenes
Xanthenes: Compounds with three aromatic rings in linear arrangement with an OXYGEN in the center ring. | 2.04 | 1 | 0 | xanthene | |
kainic acid
Kainic Acid: (2S-(2 alpha,3 beta,4 beta))-2-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid. Ascaricide obtained from the red alga Digenea simplex. It is a potent excitatory amino acid agonist at some types of excitatory amino acid receptors and has been used to discriminate among receptor types. Like many excitatory amino acid agonists it can cause neurotoxicity and has been used experimentally for that purpose. | 2.47 | 2 | 0 | dicarboxylic acid;
L-proline derivative;
non-proteinogenic L-alpha-amino acid;
pyrrolidinecarboxylic acid | antinematodal drug;
excitatory amino acid agonist |
chromium
Chromium: A trace element that plays a role in glucose metabolism. It has the atomic symbol Cr, atomic number 24, and atomic weight 52. According to the Fourth Annual Report on Carcinogens (NTP85-002,1985), chromium and some of its compounds have been listed as known carcinogens.. chromium ion : An chromium atom having a net electric charge.. chromium atom : A chromium group element atom that has atomic number 24. | 2.04 | 1 | 0 | chromium group element atom;
metal allergen | micronutrient |
phalloidine
Phalloidine: Very toxic polypeptide isolated mainly from AMANITA phalloides (Agaricaceae) or death cup; causes fatal liver, kidney and CNS damage in mushroom poisoning; used in the study of liver damage.. phalloidin : A homodetic bicyclic heptapeptide having a sulfide bridge. | 2.04 | 1 | 0 | homodetic cyclic peptide | |
texas red
Texas red: hydrophilic Texas red; structure given in first source | 2.04 | 1 | 0 | organic heteroheptacyclic compound | fluorochrome |
domoic acid
domoic acid: kainic acid analog, heterocyclic amino acid from seaweed; RN given refers to parent cpd; structure. domoic acid : An L-proline derivative that is L-proline substituted by a carboxymethyl group at position 3 and a 6-carboxyhepta-2,4-dien-2-yl group at position 4. It is produced by the diatomic algal Pseudo-nitzschia. It is an analogue of kainic acid and a neurotoxin which causes amnesic shellfish poisoning (ASP). | 2.47 | 2 | 0 | L-proline derivative;
non-proteinogenic L-alpha-amino acid;
pyrrolidinecarboxylic acid;
tricarboxylic acid | algal metabolite;
hapten;
marine metabolite;
neuromuscular agent;
neurotoxin |
pectenotoxin 2
pectenotoxin 2: isolated from the marine sponges Poecillastra and Jaspis; structure in first source | 3.29 | 6 | 0 | polycyclic ether;
spiroketal | marine metabolite |
pectenotoxin 6
pectenotoxin 6: isolated from scallops (Patinopecten yessoensis); structure in first source | 2.46 | 2 | 0 | polycyclic ether;
spiroketal | marine metabolite |
pectenotoxin-4
pectenotoxin-4: structure in first source | 2.03 | 1 | 0 | | |
yessotoxin
yessotoxin: produced by dinoflagellates and accumulated in invertebrates (e.g., Patinopecten gessoensis also known as YESSO SCALLOP) that feed on them. RN given refers to parent compound | 4.64 | 8 | 0 | ciguatoxin | |
nad
NAD(1-) : An anionic form of nicotinamide adenine dinucleotide arising from deprotonation of the two OH groups of the diphosphate moiety. | 2.04 | 1 | 0 | organophosphate oxoanion | cofactor;
human metabolite;
hydrogen acceptor;
Saccharomyces cerevisiae metabolite |
dinophysistoxin 1
dinophysistoxin 1: from toxic dinoflagellate Dinophysis fortii; RN given for (35R)-isomer; structure given in first source. dinophysistoxin 1 : A ketal that is a marine toxin structurally related to okadaic acid. Produced by dinoflagellates it is known to accumulate in shellfish and cause diarrhoeic shellfish poisoning. It is an inhibitor of serine/threonine protein phosphatases 1 (PP1) and PP2A and has been shown to promote cancer cell growth in tumour cell lines and animal models. | 3.78 | 3 | 0 | ketal | animal metabolite;
EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor;
marine metabolite;
toxin |
azaspiracid
azaspiracid: a toxin from mussels produced in Ireland that caused multiple organ damage; structure in first source | 2.99 | 4 | 0 | | |
brevetoxin
brevetoxin: from Ptychodiscus brevis | 2.1 | 1 | 0 | | |
okadaic acid
Okadaic Acid: A specific inhibitor of phosphoserine/threonine protein phosphatase 1 and 2a. It is also a potent tumor promoter. It is produced by DINOFLAGELLATES and causes diarrhetic SHELLFISH POISONING.. okadaic acid : A polycyclic ether that is produced by several species of dinoflagellates, and is known to accumulate in both marine sponges and shellfish. A polyketide, polyether derivative of a C38 fatty acid, it is one of the primary causes of diarrhetic shellfish poisoning (DSP). It is a potent inhibitor of specific protein phosphatases and is known to have a variety of negative effects on cells. | 4.83 | 10 | 0 | ketal | |
dinophysistoxin 2
dinophysistoxin 2: structure given in first source; a principal toxin responsible for diarrhetic shellfish poisoning. dinophysistoxin 2 : A ketal that is a rare marine toxin structurally related to okadaic acid. Found yearly along with okadaic acid in Portuguese shellfish, its presence has been correlated with the occurrence of Dinophysis acta. | 3.58 | 2 | 0 | ketal | EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor;
toxin |
gymnodimine
gymnodimine: a spiro-imine algal toxin; a neurotoxic shellfish poison produced by Karenia selliformis (formerly Gymnodinium selliforme) and related species | 2.06 | 1 | 0 | | |