5-sulfooxymethylfurfural

Description

5-sulfooxymethylfurfural: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Synonym
5-sulfoxymethylfurfural
159091-35-7
(5-ormyluran-2-yl)methyl hydrogen sulate
CHEBI:172448
ccris 7269
5-((sulfooxy)methyl)-2-furancarboxaldehyde
5-sulfooxymethylfurfural
(5-formylfuran-2-yl)methyl hydrogen sulfate
DTXSID10166565
SCHEMBL17079156
5MT9W9WN4L
2-furancarboxaldehyde, 5-[(sulfooxy)methyl]-
5-[(sulfooxy)methyl]-2-furancarboxaldehyde

Excerpt	Relevance	Reference
" At a dosage of 250 mg/kg, most animals died after 5-11 days due to massive damage to proximal tubules."	( Toxicity studies with 5-hydroxymethylfurfural and its metabolite 5-sulphooxymethylfurfural in wild-type mice and transgenic mice expressing human sulphotransferases 1A1 and 1A2. Bauer-Marinovic, M; Florian, S; Glatt, H; Taugner, F, 2012)	0.38

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Class	Description
arenecarbaldehyde	Any aldehyde in which the carbonyl group is attached to an aromatic moiety.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	1 (14.29)	18.2507
2000's	2 (28.57)	29.6817
2010's	4 (57.14)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	7 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
furaldehyde Furaldehyde: A heterocyclic compound consisting of a furan where the hydrogen at position 2 is substituted by a formyl group.. furfural : An aldehyde that is furan with the hydrogen at position 2 substituted by a formyl group.	3.43	7	aldehyde; furans	Maillard reaction product; metabolite
azoxymethane Azoxymethane: A potent carcinogen and neurotoxic compound. It is particularly effective in inducing colon carcinomas.	2.07	1
5-hydroxymethylfurfural 5-hydroxymethylfurfural: has antisickling activity; HMF is the causative component in honey that affects the presystemic metabolism and pharmacokinetics of GZ in-vivo. 5-hydroxymethylfurfural : A member of the class of furans that is furan which is substituted at positions 2 and 5 by formyl and hydroxymethyl substituents, respectively. Virtually absent from fresh foods, it is naturally generated in sugar-containing foods during storage, and especially by drying or cooking. It is the causative component in honey that affects the presystemic metabolism and pharmacokinetics of GZ in-vivo.	3.3	6	arenecarbaldehyde; furans; primary alcohol	indicator; Maillard reaction product

Condition	Relationship Strength	Studies
Adenoma, Basal Cell [description not available]	2.05	1
Cancer of Intestines [description not available]	2.05	1
Condition, Preneoplastic [description not available]	2.05	1
Adenoma A benign epithelial tumor with a glandular organization.	7.05	1
Intestinal Neoplasms Tumors or cancer of the INTESTINES.	2.05	1
Necrosis The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.	2.46	2
Precancerous Conditions Pathological conditions that tend eventually to become malignant.	2.05	1
Aberrant Crypt Foci Clusters of colonic crypts that appear different from the surrounding mucosa when visualized after staining. They are of interest as putative precursors to colorectal adenomas and potential biomarkers for colorectal carcinoma.	7.07	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.07	1
Experimental Hepatoma [description not available]	1.98	1