Protein tyrosine phosphatase type IVA 2

A protein tyrosine phosphatase type IVA 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q12974]

EC 3.1.3.48;
HU-PP-1;
OV-1;
PTP(CAAXII);
Protein-tyrosine phosphatase 4a2;
Protein-tyrosine phosphatase of regenerating liver 2;
PRL-2

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
pentamidine	Homo sapiens (human)	IC50	0.3000	1	1

This protein enables 3 target(s):

Target	Category	Definition
prenylated protein tyrosine phosphatase activity	molecular function	Catalysis of the reaction: prenylated-protein tyrosine phosphate + H2O = prenylated-protein tyrosine + phosphate. [EC:3.1.3.48]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
protein tyrosine phosphatase activity	molecular function	Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. [EC:3.1.3.48]

This protein is located in 4 target(s):

Target	Category	Definition
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
early endosome	cellular component	A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways. [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

This protein is active in 2 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]