A neutrophil cytosol factor 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P14598]
NCF-1; This protein enables 7 target(s): This protein is located in 7 target(s): This protein is active in 1 target(s): This protein is part of 1 target(s): This protein is involved in 17 target(s):
47 kDa autosomal chronic granulomatous disease protein;
47 kDa neutrophil oxidase factor;
NCF-47K;
Neutrophil NADPH oxidase factor 1;
Nox organizer 2;
Nox-organizing protein 2;
SH3 and PX domain-containing protein 1A;Research
Bioassay Publications (1)
Timeframe Studies on this Protein(%) All Drugs % pre-1990 0 (0.00) 18.7374 1990's 0 (0.00) 18.2507 2000's 0 (0.00) 29.6817 2010's 0 (0.00) 24.3611 2020's 1 (100.00) 2.80 Compounds (18)
Drugs with Inhibition Measurements
Drug Taxonomy Measurement Average (mM) Bioassay(s) Publication(s) 1-(1-naphthyl)piperazine Homo sapiens (human) Ki 1,520.0000 1 1 ebselen Homo sapiens (human) Ki 125.0000 3 3 quipazine Homo sapiens (human) Ki 1,410.0000 1 1 carbostyril Homo sapiens (human) Ki 2,000.0000 1 1 quinoline Homo sapiens (human) Ki 2,000.0000 1 1 2-naphthylamine Homo sapiens (human) Ki 2,000.0000 1 1 2-methylquinoline Homo sapiens (human) Ki 2,000.0000 1 1 2-aminopyrimidine Homo sapiens (human) Ki 2,000.0000 1 1 2-aminobenzothiazole Homo sapiens (human) Ki 2,000.0000 1 1 alpha-aminopyridine Homo sapiens (human) Ki 2,000.0000 1 1 8-aminoquinoline Homo sapiens (human) Ki 2,000.0000 1 1 6-aminoquinoline Homo sapiens (human) Ki 2,000.0000 1 1 1,2-Dihydroquinolin-2-imine Homo sapiens (human) Ki 428.0000 1 1 5-aminoquinoline Homo sapiens (human) Ki 2,000.0000 1 1 4-aminoquinoline Homo sapiens (human) Ki 1,520.0000 1 1 1-(4-pyridyl)piperazine Homo sapiens (human) Ki 302.0000 1 1 1-aminoisoquinoline Homo sapiens (human) Ki 594.0000 1 1 4-amino-2-methylquinoline Homo sapiens (human) Ki 1,070.0000 1 1 Drugs with Activation Measurements
Drug Taxonomy Measurement Average (mM) Bioassay(s) Publication(s) 1-(1-naphthyl)piperazine Homo sapiens (human) Kd 366.0000 1 1 quipazine Homo sapiens (human) Kd 420.0000 1 1 1,2-Dihydroquinolin-2-imine Homo sapiens (human) Kd 488.0000 1 1 4-aminoquinoline Homo sapiens (human) Kd 765.0000 1 1 1-aminoisoquinoline Homo sapiens (human) Kd 687.0000 1 1 4-amino-2-methylquinoline Homo sapiens (human) Kd 521.0000 1 1 Enables
Target Category Definition protein binding molecular function Binding to a protein. [GOC:go_curators] electron transfer activity molecular function A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. [Wikipedia:Electron_transfer] superoxide-generating NAD(P)H oxidase activity molecular function Catalysis of the reaction: NAD(P)H + O2 = NAD(P)H + O2-. [GOC:ai, PMID:10806195] SH3 domain binding molecular function Binding to a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins. [GOC:go_curators, Pfam:PF00018] phosphatidylinositol binding molecular function Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives. [GOC:bf, ISBN:0198506732, PMID:11395417] phosphatidylinositol-3,4-bisphosphate binding molecular function Binding to phosphatidylinositol-3,4-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 4' positions. [GOC:bf, GOC:go_curators] superoxide-generating NADPH oxidase activator activity molecular function Binds to and increases the activity of the enzyme superoxide-generating NADPH oxidase. [GOC:ai] Located In
Target Category Definition cytosol cellular component The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] plasma membrane cellular component The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] cytoplasmic side of plasma membrane cellular component The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface. [GOC:dos, GOC:tb] membrane cellular component A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] dendrite cellular component A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732] phagolysosome cellular component A membrane-bounded intracellular vesicle formed by maturation of an early phagosome following the ingestion of particulate material by phagocytosis; during maturation, phagosomes acquire markers of late endosomes and lysosomes. [GOC:mah, PMID:12388753, PMID:14733906] neuronal cell body cellular component The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. [GOC:go_curators] Active In
Target Category Definition cytoplasm cellular component The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] Part Of
Target Category Definition NADPH oxidase complex cellular component A enzyme complex of which the core is a heterodimer composed of a light (alpha) and heavy (beta) chain, and requires several other water-soluble proteins of cytosolic origin for activity. Functions in superoxide generation by the NADPH-dependent reduction of O2. [GOC:jl, PMID:11483596, PMID:12440767] Involved In
Target Category Definition protein targeting to membrane biological process The process of directing proteins towards a membrane, usually using signals contained within the protein. [GOC:curators] superoxide metabolic process biological process The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species. [GOC:jl] cellular defense response biological process A defense response that is mediated by cells. [GOC:ebc] cellular response to reactive oxygen species biological process Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals. [GOC:mah] superoxide anion generation biological process The enzymatic generation of superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species, by a cell in response to environmental stress, thereby mediating the activation of various stress-inducible signaling pathways. [GOC:jl, PMID:12359750] innate immune response biological process Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu] respiratory burst biological process A phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals. [ISBN:0198506732] positive regulation of epidermal growth factor-activated receptor activity biological process Any process that activates or increases the frequency, rate or extent of EGF-activated receptor activity. [GOC:go_curators] positive regulation of DNA-templated transcription biological process Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH] positive regulation of JNK cascade biological process Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade. [GOC:bf] positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction biological process Any process that activates or increases the frequency, rate or extent of phosphatidylinositol 3-kinase/protein kinase B signal transduction. [GOC:ai] regulation of respiratory burst involved in inflammatory response biological process Any process that modulates the rate, frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases made as a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals. [GOC:BHF, GOC:dph, GOC:rl, GOC:tb] cellular response to cadmium ion biological process Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus. [GOC:mah] cellular response to glucose stimulus biological process Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus. [GOC:mah] cellular response to testosterone stimulus biological process Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a testosterone stimulus. [GOC:mah] positive regulation of p38MAPK cascade biological process Any process that activates or increases the frequency, rate or extent of p38MAPK cascade. [GOC:TermGenie] reactive oxygen species biosynthetic process biological process The chemical reactions and pathways resulting in the formation of reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen. [GO_REF:0000068, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24252804]