| ID Source | ID |
|---|---|
| PubMed CID | 441401 |
| CHEMBL ID | 126 |
| CHEBI ID | 63607 |
| SCHEMBL ID | 5027 |
| MeSH ID | M0257529 |
| Synonym |
|---|
| BIDD:GT0404 |
| HY-10394 |
| AB00639994-08 |
| n-(((s)-3-(3-fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl)methyl)acetamide |
| c16h20fn3o4 |
| zyvoxa |
| zyvoxid |
| acetamide, n-((3-(3-fluoro-4-(4-morpholinyl)phenyl)-2-oxo-5-oxazolidinyl)methyl)-, (s)- |
| acetamide, n-(((5s)-3-(3-fluoro-4-(4-morpholinyl)phenyl)-2-oxo-5-oxazolidinyl)methyl)- |
| u 100766 |
| hsdb 7478 |
| pnu 100766 |
| zyvoxam |
| n-((3-(3-fluoro-4-morpholinylphenyl)-2-oxo-5-oxazolidinyl)methyl)acetamide |
| linezolid & vrc3375 |
| MLS001424075 |
| C08146 |
| 165800-03-3 |
| LINEZOLID , |
| pnu-100766 |
| zyvox |
| nda 21-132 zyvox oral suspension (linzolid oral suspension) |
| nda 21-130 zyvox (linezolid tablets) |
| (s)-n-[[3-(3-fluoro-4-morpholinylphenyl)-2-oxo-5-oxazolidinyl]methyl]acetamide |
| nda 21-131 zyvox for injection (linezolid injection) |
| u-100766 |
| n-[[(5s)-3-(3-fluoro-4-morpholino-phenyl)-2-oxo-oxazolidin-5-yl]methyl]acetamide |
| MLS000759444 |
| smr000466335 |
| cpd000466335 |
| DB00601 |
| D00947 |
| linezolid (jan/usan/inn) |
| zyvox (tn) |
| NCGC00164628-01 |
| ZLD , |
| n-{[(5s)-3-(3-fluoro-4-morpholin-4-ylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl}acetamide |
| HMS2089K06 |
| HMS2051F08 |
| CHEMBL126 , |
| u-100,766 |
| chebi:63607 , |
| 111GE017 , |
| benzotriazol-2-yl-acetonitrile |
| (s)-n-((3-(3-fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl)acetamide |
| n-[(r)-3-(3-fluoro-4-morpholin-4-yl-phenyl)-2-oxo-oxazolidin-5-ylmethyl]-acetamide |
| n-((s)-2-oxo-3-(s)-2,3,3a,4-tetrahydro-1h-benzo[b]pyrrolo[1,2-d][1,4]oxazin-7-yl-oxazolidin-5-ylmethyl)-acetamide |
| (s)-3-(3-fluoro-4-morpholin-4-yl-phenyl)-5-[(1-hydroxy-ethylamino)-methyl]-oxazolidin-2-one |
| n-[(s)-3-(3-fluoro-4-morpholin-4-yl-phenyl)-2-oxo-oxazolidin-5-ylmethyl]-acetamide |
| n-[3-(3-fluoro-4-morpholin-4-yl-phenyl)-2-oxo-oxazolidin-5-ylmethyl]-acetamide(linezolid) |
| (linezolid)n-[3-(3-fluoro-4-morpholin-4-yl-phenyl)-2-oxo-oxazolidin-5-ylmethyl]-acetamide |
| (s)-n-((3-fluoro-4-morpholinophenyl)-2-oxaoxazolidin-5-yl)methyl)acetamide |
| bdbm50116067 |
| linezoid |
| cid_441401 |
| n-[3-(3-fluoro-4-morpholin-4-yl-phenyl)-2-oxo-oxazolidin-5-ylmethyl]-acetamide |
| n-[[(5s)-3-(3-fluoro-4-morpholin-4-ylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamide |
| A810662 |
| n-[[(5s)-3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide |
| n-[[(5s)-3-(3-fluoranyl-4-morpholin-4-yl-phenyl)-2-oxidanylidene-1,3-oxazolidin-5-yl]methyl]ethanamide |
| HMS3260C14 |
| linezolide |
| dtxcid3026489 |
| dtxsid5046489 , |
| tox21_112246 |
| cas-165800-03-3 |
| CCG-101009 |
| linezolid [usan:inn:ban] |
| isq9i6j12j , |
| zivoxid |
| unii-isq9i6j12j |
| BCP9000855 |
| NCGC00263531-03 |
| n-({(5s)-3-[3-fluoro-4-(morpholin-4-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)acetamide |
| linezolid [hsdb] |
| n-[[(s)-3-(3-fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methyl]acetamide |
| linezolid [usp-rs] |
| linezolid [usp monograph] |
| linezolid [inn] |
| linezolid [mart.] |
| linezolid [jan] |
| linezolid [usan] |
| linezolid [vandf] |
| linezolid [who-dd] |
| linezolid [orange book] |
| linezolid [mi] |
| AM84567 |
| CS-0756 |
| S1408 |
| KS-1178 |
| AKOS016340522 |
| AB00639994-06 |
| NC00259 |
| SCHEMBL5027 |
| AB00639994-09 |
| tox21_500096 |
| NCGC00260781-01 |
| (s)-n-((3-(3-fluoro-4-(4-morpholinyl)phenyl)-2-oxo-5-oxazolidinyl)methyl)acetamide |
| (s)-n-[ [3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxo-oxazolidin-5-yl]methyl]-acetamide |
| (s)-n-[[3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]-acetamide |
| Q-201308 |
| linezolid, pharmaceutical secondary standard; certified reference material |
| acetamide, n-[[(5s)-3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]- |
| AB00639994_11 |
| AB00639994_10 |
| n-{[(5s)-3-[3-fluoro-4-(morpholin-4-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl}acetamide |
| pnu100766 |
| SR-01000759376-5 |
| sr-01000759376 |
| SR-01000759376-4 |
| linezolid, united states pharmacopeia (usp) reference standard |
| linezolid, >=98% (hplc) |
| NCGC00263531-10 |
| HMS3713K10 |
| linezolid (pnu-100766) |
| SW197639-3 |
| BCP05586 |
| Q411377 |
| linezolid (zyvox) |
| gtpl10827 |
| NCGC00263531-05 |
| SR-01000759376-11 |
| linezolid 100 microg/ml in acetonitrile |
| HB4443 |
| L0362 |
| Z1515385084 |
| n-(((5s)-3-(3-fluoro-4-(morpholin-4-yl)phenyl)-2-oxo-1,3-oxazolidin-5-yl)methyl)acetamide |
| linezolid (usp-rs) |
| n-(((5s)-3-(3-fluoro-4-(4-morpholinyl)phenyl)-2-oxo-5-oxazolidinyl)acetamide |
| linezolidum |
| linezolid in sodium chloride 0.9% in plastic container |
| j01xx08 |
| linezolid (mart.) |
| linezolid (usp monograph) |
Linezolid is a critically important antibiotic used to treat human infections caused by MRSA and VRE. It is an oxazolidinone antibacterial drug, and its therapeutic drug monitoring and individualized treatment have been challenged since its approval.
Linezolid has a unique structure and mechanism of action, which targets protein synthesis at an exceedingly early stage. It is amenable to oral or parenteral administration and potentially useful for continuing outpatient therapy that was initiated for inpatients.
Linezolid has a wide spectrum of activity against gram-positive organisms. Blood count monitoring is recommended in patients receiving this drug for long-term therapy. Linezolid also provided improved outcomes in the treatment of serious vancomycin-resistant entrococci and methicillin-resistant Staphylococcus aureus.
Linezolid did not inhibit the independent binding of either mRNA or N-formylmethionyl-tRNA to E. Linezolid may cause reversible optic neuropathy and irreversible peripheral neuropathy after months of treatment. LineZolid can cause serious adverse effects including thrombocytopenia and anemia.
Linezolid improves the treatment outcomes of multidrug-resistant tuberculosis substantially. Linezolid-related treatment interruption is common, is strongly associated with HIV co-infection, and system-specific toxicity occurs within predictable time frames.
Linezolid was significantly related to higher adverse events than ampicillin/sulbactam. Among children with MDR-TB there are no linezolid pharmacokinetic data, and its adverse effects have not yet been prospectively described.
The aim of the study was to assess the biliary penetration of linezolid and the probabilities of attaining optimal pharmacodynamic exposure against vancomycin-resistant enterococci in the bile of liver transplant (LTx) patients. The purpose was to describe the pharmacokinetic profile and determine the level of penetration oflinezolid into healthy thigh tissue.
Linezolid in combination with ertapenem showed in vitro synergy against methicillin-resistant Staphylococcus aureus strains. When combined with 8 mg/L rifampicin, MBECs for ciprofloxacin and linezolid dropped to 16-32mg/L.
Linezolid, an oxazolidinone antibiotic, has 100% oral bioavailability. The bioavailability of linezolid is not impaired by RYGBS. Linezolid offers a valuable alternative to more traditional therapies, such as glycopeptides.
| Excerpt | Reference | Relevance |
|---|---|---|
| "The Upjohn oxazolidinones, U-100592 and U-100766, are orally bioavailable synthetic antimicrobial agents with spectra of activity against antibiotic-susceptible and -resistant gram-positive pathogens." | ( In vivo activities of U-100592 and U-100766, novel oxazolidinone antimicrobial agents, against experimental bacterial infections. Barbachyn, MR; Brickner, SJ; Ford, CW; Hamel, JC; Hutchinson, DK; Moerman, JK; Stapert, D; Wilson, DM; Yancey, RJ, 1996) | 0.29 |
| " Linezolid, the oxazolidinone which has been selected for clinical development, has near complete oral bioavailability plus favourable pharmacokinetic and toxicity profiles." | ( Oxazolidinones: a review. Diekema, DI; Jones, RN, 2000) | 1.22 |
| " It has good pharmacokinetics, with equal bioavailability by both oral and intravenous routes and no need for dose adjustment in patients with renal impairment." | ( Linezolid. French, G, ) | 1.57 |
| " Linezolid has almost 100% bioavailability and the area under the plasma concentration curve is identical after oral and iv." | ( Linezolid--a review of the first oxazolidinone. Norrby, R, 2001) | 2.66 |
| " Linezolid may be administered either intravenously or orally with oral bioavailability of approximately 100% and limited adverse effects." | ( The oxazolidinones as a new family of antimicrobial agent. Marchese, A; Schito, GC, 2001) | 1.22 |
| " The objectives of this study were twofold: (1) to compare the absorption of linezolid tablets given immediately following a high-fat meal with the absorption of tablets administered while fasting, and (2) to assess the bioavailability of a 375-mg oral dose given while fasting relative to a 375-mg dose of linezolid sterile solution given intravenously." | ( Linezolid absolute bioavailability and the effect of food on oral bioavailability. Hopkins, NK; Jungbluth, GL; Sisson, TA; Stalker, DJ; Welshman, IR, 2001) | 1.98 |
| " Linezolid is a parenteral agent that also possesses near-complete oral bioavailability plus favourable pharmacokinetic and toxic effect profiles." | ( Oxazolidinone antibiotics. Diekema, DJ; Jones, RN, 2001) | 1.22 |
| " It is well absorbed with high bioavailability that allows conversion to oral therapy as soon as the patient is clinically stable." | ( Linezolid: its role in the treatment of gram-positive, drug-resistant bacterial infections. Ament, PW; Horne, JP; Jamshed, N, 2002) | 1.76 |
| " bioavailability of > 95% in rat and dog, and > 70% in mouse." | ( Pharmacokinetics, toxicokinetics, distribution, metabolism and excretion of linezolid in mouse, rat and dog. Adams, LA; Bush, EC; Chiba, K; Daley-Yates, PT; Feenstra, KL; Koike, S; Ozawa, N; Peng, GW; Sams, JP; Schuette, MR; Slatter, JG; Yamazaki, S, 2002) | 0.54 |
| " LZD is rapidly absorbed following oral administration and bioavailability when compared with intravenous administration is almost 100%." | ( [Antimicrobial and clinical effect of linezolid (ZYVOX), new class of synthetic antibacterial drug]. Hashimoto, M; Irinoda, K; Nomura, S, 2002) | 0.59 |
| " Oral bioavailability in humans was determined to be 100% and twice daily dosing in humans resulted in blood levels which even at trough values were in excess of the MIC90 for significant Gram-positive pathogens." | ( The discovery of linezolid, the first oxazolidinone antibacterial agent. Barbachyn, MR; Ford, CW; Zurenko, GE, 2001) | 0.65 |
| " Virtually complete oral bioavailability allows for 1:1 conversion between the intravenous and oral dosage forms." | ( Linezolid: an oxazolidinone antimicrobial agent. Paladino, JA, 2002) | 1.76 |
| " The almost-complete bioavailability of linezolid permits oral administration." | ( Quinupristin-dalfopristin and linezolid: evidence and opinion. Eliopoulos, GM, 2003) | 0.88 |
| "Linezolid, an oxazolidinone antibiotic, has 100% oral bioavailability and favorable activities against gram-positive pathogens including multidrug-resistant staphylococci, enterococci, and pneumococci." | ( Worldwide assessment of linezolid's clinical safety and tolerability: comparator-controlled phase III studies. Cammarata, S; Hafkin, B; Isturiz, R; Le, V; Oliphant, TH; Remington, J; Rubinstein, E; Smith, LG; Standiford, HC, 2003) | 2.07 |
| " Linezolid has complete bioavailability in parenteral and oral administration, is well tolerated and shows little toxicity, thus favoring a shortened hospital stay, improving the patient's quality of life and reducing social costs." | ( Treatment of gram-positive surgical sepsis: role of the oxazolidinones. Carnuccio, P; Colizza, S; Cucchiara, G; Rodio, F; Rossi, S, 2003) | 1.23 |
| " Oral linezolid has excellent bioavailability and activity against MRSA and MR-CoNS and offers the potential for outpatient treatment of MRSA and MR-CoNS infections." | ( Early switch and early discharge opportunities in intravenous vancomycin treatment of suspected methicillin-resistant staphylococcal species infections. Goetz, MB; Parodi, S; Rhew, DC, ) | 0.61 |
| " Linezolid possesses a high activity against all multiresistant gram-positive cocci, favourable pharmacokinetics, a good safety profile, a complete bioavailability after and administration permitting switch therapy, a low capacity of inducing resistance, and both clinical and microbiologic efficacy as demonstrated by a number of clinical trials conducted on thousands of patients." | ( [The role of linezolid in the therapy of infections caused by multiresistant gram-positive cocci]. Corti, G; Paradisi, F, 2004) | 1.6 |
| " The compound's excellent oral bioavailability and reasonable safety profile, along with the increasing incidence of resistant infections, means that linezolid offers a valuable alternative to more traditional therapies such as vancomycin." | ( The safety and efficacy of linezolid in orthopaedic practice for the treatment of infection due to antibiotic-resistant organisms. Giannoudis, PV; Harwood, PJ, 2004) | 0.82 |
| " The excellent bioavailability after oral administration (almost 100%) makes it suitable for outpatient treatment and treatment by general practitioners." | ( [Linezolid, an agent from a new class of antibiotics]. Bernards, AT; Kuijper, EJ; Schippers, EF, 2004) | 1.23 |
| "Linezolid is an oxazolidinone antimicrobial with excellent oral bioavailability and tissue penetration and is active against multidrug-resistant skin/soft tissue pathogens." | ( Pharmacokinetics and pharmacodynamics of linezolid in obese patients with cellulitis. Citron, DM; Goldstein, EJ; Havlichek, DH; Kak, V; Peloquin, CA; Schooley, SL; Stein, GE; Tyrrell, KL, 2005) | 2.04 |
| " With an excellent oral bioavailability and acceptable safety profile, linezolid offers a valuable alternative to more traditional therapies, such as glycopeptides." | ( Role of linezolid in the treatment of orthopedic infections. Bassetti, D; Bassetti, M; Beltrame, A; Di Biagio, A; Righi, E; Rosso, R, 2005) | 1 |
| " Therefore, the bioavailability of linezolid administered enterally in the presence of enteral feedings in hospitalized patients was examined." | ( Absolute bioavailability and pharmacokinetics of linezolid in hospitalized patients given enteral feedings. Beringer, P; Gill, M; Gurevitch, M; Hoem, N; Louie, S; Nguyen, M; Wong-Beringer, A, 2005) | 0.86 |
| " Linezolid is a pararental drug that also possesses near-complete oral bioavailability and a favourable pharmacokinetic profile." | ( Oxazolidinones--a new class of broad-spectrum chemotherapeutics. Pasternak, K; Sztanke, K; Sztanke, M, 2004) | 1.23 |
| " The oral bioavailability of linezolid is approximately 100%, thus allowing sequential intravenous-to-oral administration without changing the drug or dosage regimen." | ( Linezolid: a pharmacoeconomic review of its use in serious Gram-positive infections. Figgitt, DP; Plosker, GL, 2005) | 2.06 |
| "The aim of this study was to determine the bioavailability of a novel oxazolidinone, DRF-6196, in mice and rats following intravenous (i." | ( Assessment of oral bioavailability and preclinical pharmacokinetics of DRF-6196, a novel oxazolidinone analogue, in comparison to linezolid. Bhamidipati, R; Das, J; Dravid, PV; Mullangi, R; Narasimhulu, PC; Srinivas, NR; Tvrs, S; Venkatesh, P, ) | 0.34 |
| " With its oral bioavailability profiles, it obviously holds great promise." | ( In vitro activity of linezolid and other antibiotics against Gram-positive bacteria from the major teaching hospitals in Kuwait. Al Sweih, N; Jamal, W; Mokaddas, E; Phillips, OA; Rotimi, VO, 2005) | 0.65 |
| " Prosthesis retention, in conjunction with debridement and prolonged (for at least 3 months) oral antibiotic therapy, can be an alternative for early postoperative or late acute haematogenous infections, when the duration of symptoms is less than 1 month, the implant is stable, and the pathogen is relatively avirulent and sensitive to an orally well absorbed antibiotic." | ( Management of infections of osteoarticular prosthesis. Barberán, J, 2006) | 0.33 |
| " Linezolid is a new antibiotic with high bioavailability and an outstanding safety profile, synergistic with imipenem, which may deserve a place in the armamentarium for severe pneumonia in children." | ( Effectiveness of linezolid and imipenem association in the treatment of severe community-acquired pneumonia in children: two case reports. Caillon, J; Christophe Roze, J; Denizot, S; Godon, N; Gras-Le Guen, C; Podevin, G; Potel, G, 2006) | 1.58 |
| " Linezolid is the first of a new class of antimicrobial agents known as the oxazolidinones with activity against gram-positive bacteria similar to that of vancomycin and yet its oral bioavailability allows for enteral administration." | ( Preliminary experience with the use of oral linezolid in infants for the completion of antibiotic therapy in the outpatient setting after admission to the pediatric intensive care unit. Sullivan, J; Tobias, JD, ) | 1.3 |
| " Linezolid is well absorbed in the intestinal system." | ( [Linezolid in the treatment of antibiotic-resistant gram-positive infections of the musculoskeletal system]. Jahoda, D; Landor, I; Nyc, O; Pokorný, D; Sosna, A, 2006) | 2.15 |
| " Pharmacocinetics studies have shown that linezolid has an excellent bioavailability allowing a fast relay per os." | ( [Linezolid: antibacterial activity, clinical efficacy and resistance]. Bourgeois-Nicolaos, N; Butel, MJ; Doucet-Populaire, F; Piriou, O, ) | 1.31 |
| " It is well absorbed with high bioavailability after oral administration and generally well tolerated." | ( [Linezolid--novel antibiotic for the treatment of gram-positive bacterial infections]. Jankowski, A; Stefanik, W, 2006) | 1.24 |
| "Linezolid is an attractive alternative for orthopedic infections because of oral bioavailability and activity against methicillin-resistant staphylococci and vancomycin-resistant enterococci." | ( Efficacy and safety of linezolid for Gram-positive orthopedic infections: a prospective case series. Hamilton, CW; Rao, N, 2007) | 2.09 |
| " Human oral bioavailability is an important pharmacokinetic property, which is directly related to the amount of drug available in the systemic circulation to exert pharmacological and therapeutic effects." | ( Hologram QSAR model for the prediction of human oral bioavailability. Andricopulo, AD; Moda, TL; Montanari, CA, 2007) | 0.34 |
| " Furthermore, in vivo efficacies and pharmacokinetic properties of the selected compounds were also disclosed herein; the selected compounds showed reasonable bioavailability as well as in vivo efficacy comparable to that of linezolid." | ( Synthesis and biological evaluation of new N-linked 5-triazolylmethyl oxazolidinones. Chen, Y; Fan, H; Ji, R; Jiang, Z; Yang, Y; Zhang, S; Zhong, D, 2008) | 0.53 |
| "The excellent oral bioavailability and the Gram-positive antimicrobial spectrum make linezolid an attractive antibiotic for treatment of osteoarticular infections." | ( Experience with linezolid therapy in children with osteoarticular infections. Chen, CJ; Chiu, CH; Huang, YC; Lee, ZL; Lin, TY; Yang, WE, 2007) | 0.91 |
| " It has an excellent bioavailability both intravenously and orally and a very good safety profile both in adults and in children." | ( Linezolid in children: recent patents and advances. Velissariou, IM, 2007) | 1.78 |
| "We have developed a first generation of hybrid sparsomycin-linezolid compounds into a new family of orally bioavailable biaryloxazolidinones that have activity against both linezolid-susceptible and -resistant gram-positive bacteria as well as the fastidious gram-negative bacteria Haemophilus influenzae and Moraxella catarrahalis." | ( Design at the atomic level: design of biaryloxazolidinones as potent orally active antibiotics. Bhattacharjee, A; Chen, S; Chen, Y; Duffy, E; Farmer, J; Goldberg, J; Hanselmann, R; Ippolito, JA; Johnson, G; Lou, R; Orbin, A; Oyelere, A; Salvino, J; Springer, D; Tran, J; Wang, D; Wu, Y; Zhou, J, 2008) | 0.59 |
| " The availability of intravenous and oral formulations, with near 100% bioavailability of the latter, is hoped to facilitate the management of multiply drug-resistant Gram-positive infections." | ( Linezolid: a review of safety and tolerability. Rubinstein, E; Vinh, DC, 2009) | 1.8 |
| "Oral bioavailability (F) is a product of fraction absorbed (Fa), fraction escaping gut-wall elimination (Fg), and fraction escaping hepatic elimination (Fh)." | ( Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV, 2010) | 0.36 |
| " PNU-100480 doses to 1000 mg were well absorbed and showed approximately proportional increases in exposures of parent and metabolites." | ( Pharmacokinetics and whole-blood bactericidal activity against Mycobacterium tuberculosis of single doses of PNU-100480 in healthy volunteers. Campbell, S; Dimitrova, D; Friedland, G; Jakubiec, WM; Kumar, V; Ladutko, L; Li, X; Miller, PF; Mitton-Fry, M; Paige, D; Silvia, AM; Wallis, RS, 2010) | 0.36 |
| " Moreover, the availability of intravenous and oral formulation with an excellent bioavailability of the latter, is hoped to facilitate the management of these infections." | ( [Linezolide in paediatrics]. Ménager, C; Moulin, F, 2010) | 1.27 |
| " It is unique amongst antibiotics active against most multiply-resistant Gram-positive bacteria in that there is an oral preparation with 100% bioavailability and an extensive volume of distribution." | ( Linezolid pharmacokinetics and pharmacodynamics in clinical treatment. Dryden, MS, 2011) | 1.81 |
| "Fusidic acid (CEM-102), an orally bioavailable fusidane antibiotic with a unique mode of action, is under development for treatment of acute gram-positive bacterial skin and skin structure infections, including those caused by methicillin-susceptible and methicillin-resistant Staphylococcus aureus and streptococci." | ( A randomized, double-blind phase 2 study comparing the efficacy and safety of an oral fusidic acid loading-dose regimen to oral linezolid for the treatment of acute bacterial skin and skin structure infections. Clark, K; Corey, GR; Craft, JC; Das, A; Degenhardt, TP; Fernandes, P; Moriarty, SR; Scott, D; Still, JG, 2011) | 0.57 |
| " This compound also showed excellent pharmacokinetic profiles, with a half-life of more than 5 h as well as an oral bioavailability of 81% in rats." | ( Design, synthesis, and structure-activity relationship studies of highly potent novel benzoxazinyl-oxazolidinone antibacterial agents. Fan, H; Gao, S; Guo, B; He, H; Huang, Y; Wang, H; Xin, Q; Yang, Y, 2011) | 0.37 |
| " Two compounds were identified that exhibit both oral bioavailability in rat and clinically relevant bacterial susceptibility profiles against major respiratory pathogens." | ( Fluorocyclines. 2. Optimization of the C-9 side-chain for antibacterial activity and oral efficacy. Achorn, C; Chen, CL; Clark, RB; Deng, Y; Fyfe, C; Grossman, TH; He, M; Hogan, PC; Hunt, DK; O'Brien, WJ; Plamondon, L; Rönn, M; Sutcliffe, JA; Xiao, XY; Zhu, Z, 2012) | 0.38 |
| " Parametric population pharmacokinetic analysis was used to evaluate bioavailability and the influence of total body weight (TBW) on pharmacokinetic parameters." | ( Oral bioavailability of linezolid before and after Roux-en-Y gastric bypass surgery: is dose modification necessary in obese subjects? Ameri, D; Hamilton, R; Pai, MP; Thai, XC, 2013) | 0.7 |
| "The bioavailability of linezolid is not impaired by RYGBS." | ( Oral bioavailability of linezolid before and after Roux-en-Y gastric bypass surgery: is dose modification necessary in obese subjects? Ameri, D; Hamilton, R; Pai, MP; Thai, XC, 2013) | 1.01 |
| "Linezolid may be an interesting alternative for prosthetic joint infection (PJI) due to its bioavailability and its antimicrobial spectrum." | ( Linezolid in late-chronic prosthetic joint infection caused by gram-positive bacteria. Ariza, J; Cobo, J; del Toro, MD; Euba, G; Jover-Sáenz, A; Lora-Tamayo, J; Palomino, J; Riera, M; Rodríguez-Pardo, D, 2013) | 3.28 |
| " This study was conducted to evaluate the pharmacokinetics (PKs) and relative bioavailability of suspension (reference) and tablet (test) formulations of Linezolid (LZD)." | ( Pharmacokinetics and relative bioavailability evaluation of linezolid suspension and tablet formulations. Helmy, SA, 2013) | 0.83 |
| " Of primary importance when treating cSSTIs is the agent's clinical efficacy against the causative pathogens, as well as its bioavailability in the skin and associated structures." | ( European perspective and update on the management of complicated skin and soft tissue infections due to methicillin-resistant Staphylococcus aureus after more than 10 years of experience with linezolid. Baguneid, M; Bassetti, M; Bouza, E; Dryden, M; Nathwani, D; Wilcox, M, 2014) | 0.59 |
| " The high oral bioavailability of linezolid makes it an attractive oral alternative to glycopeptides and its use has increased in the last decade." | ( Clinical experience with linezolid for the treatment of orthopaedic implant infections. García-Ramiro, S; Martínez-Pastor, JC; Mensa, J; Morata, L; Soriano, A; Tornero, E, 2014) | 0.98 |
| " This antibiotic is bactericidal and is orally bioavailable in mice." | ( Structure-activity relationship for the oxadiazole class of antibiotics. Antunes, NT; Boudreau, MA; Chang, M; Ding, D; Lastochkin, E; Leemans, E; Lichtenwalter, K; Mobashery, S; O'Daniel, PI; Peng, Z; Pi, H; Schroeder, VA; Song, W; Spink, E; Suckow, MA; Testero, SA; Vakulenko, S; Wolter, WR, 2015) | 0.42 |
| " The compound also demonstrated high oral bioavailability (F = 99." | ( Discovery of a Teraryl Oxazolidinone Compound (S)-N-((3-(3-Fluoro-4-(4-(pyridin-2-yl)-1H-pyrazol-1-yl)phenyl)-2-oxooxazolidin-5-yl)methyl)acetamide Phosphate as a Novel Antimicrobial Agent with Enhanced Safety Profile and Efficacies. Ang, W; Chang, Y; Chen, G; Li, G; Liu, Y; Long, H; Luo, Y; Sang, Z; Tang, J; Wang, Z; Wei, Y; Yang, S; Yang, T; Yang, X; Zhang, J, 2015) | 0.42 |
| " This new quinazolinone has potent activity against methicillin-resistant (MRSA) strains, low clearance, oral bioavailability and shows efficacy in a mouse neutropenic thigh infection model." | ( Structure-Activity Relationship for the 4(3H)-Quinazolinone Antibacterials. Bastian, M; Bouley, R; Chang, M; Ding, D; Lastochkin, E; Mobashery, S; Peng, Z; Schroeder, VA; Song, W; Suckow, MA; Wolter, WR, 2016) | 0.43 |
| " Pharmacokinetic parameters such as oral clearance, oral volume of distribution of the central compartment, time to reach maximum plasma concentration, absorption rate constant, and half-life in humans were predicted from animals using allometric scaling." | ( Prediction of Plasma Concentration-time Profiles of Drugs in Humans from Animals Following Oral Administration: An Allometric Approach. Mahmood, I, 2016) | 0.43 |
| "Tedizolid is an orally bioavailable oxazolidinone with once-daily dosing and broad-spectrum Gram-positive activity." | ( Exploring the pharmacodynamic interactions between tedizolid and other orally bioavailable antimicrobials against Staphylococcus aureus and Staphylococcus epidermidis. Werth, BJ, 2017) | 0.46 |
| " The addition of other orally bioavailable anti-staphylococcal agents to tedizolid may be unlikely to improve killing but further research is warranted to assess the impact of these combinations on resistance prevention, or against biofilm-embedded organisms." | ( Exploring the pharmacodynamic interactions between tedizolid and other orally bioavailable antimicrobials against Staphylococcus aureus and Staphylococcus epidermidis. Werth, BJ, 2017) | 0.46 |
| " Oral MRX-I was associated with a greater bioavailability and exposure when administered with food, and minimal accumulation of MRX-I occurred after multiple-dose administration." | ( Single- and Multiple-Dose Study To Determine the Safety, Tolerability, Pharmacokinetics, and Food Effect of Oral MRX-I versus Linezolid in Healthy Adult Subjects. Eckburg, PB; Ge, Y; Hafkin, B, 2017) | 0.66 |
| " Pharmacokinetic studies indicate that 1 has an oral bioavailability with an average F-value of 27." | ( An antimycobacterial pleuromutilin analogue effective against dormant bacilli. Eslamimehr, S; Franzblau, SG; Kong, Y; Kurosu, M; Lemieux, MR; Mitachi, K; Park, F; Pressly, JD; Siricilla, S; Wang, Y; Yang, D, 2018) | 0.48 |
| " These compounds were found to be orally bioavailable and highly effective." | ( Synthesis, antituberculosis studies and biological evaluation of new quinoline derivatives carrying 1,2,4-oxadiazole moiety. Eswaran, S; Narayanan, S; Shivarudraiah, P; Shruthi, TG; Subramanian, S, 2019) | 0.51 |
| " Consequently, compound 10 was orally bioavailable with a highly-acceptable pharmacokinetic profile in vivo that exhibited a half-life of 4 h and achieved a maximum plasma concentration that exceeded the minimum inhibitory concentration (MIC) values against all tested bacterial isolates." | ( Phenylthiazoles with nitrogenous side chain: An approach to overcome molecular obesity. Abutaleb, NS; Elsebaei, MM; Hagras, M; Li, D; Mahgoub, AA; Mayhoub, AS; Mohammad, H; Seleem, MN, 2019) | 0.51 |
| "The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs." | ( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019) | 0.51 |
| " Pharmacokinetic analysis showed that bioavailability of oral levonadifloxacin was 90% and similar pharmacokinetic profile of levonadifloxacin by both routes provide an option for IV to oral switch for the treatment of subjects." | ( Efficacy and Safety of a Novel Broad-Spectrum Anti-MRSA Agent Levonadifloxacin Compared with Linezolid for Acute Bacterial Skin and Skin Structure Infections: A Phase 3, Openlabel, Randomized Study. Bhagwat, S; Bhatia, A; Chavan, R; Friedland, HD; Gutte, R; Joshi, P; Kumbhar, D; Llorens, L; Mastim, M; Palwe, SR; Patel, M; Periasamy, H; Shah, M, 2020) | 0.78 |
| "Many lead compounds fail to reach clinical trials despite being potent because of low bioavailability attributed to their insufficient solubility making solubility a primary and crucial factor in early phase drug discovery." | ( Structural modification aimed for improving solubility of lead compounds in early phase drug discovery. Baidya, ATK; Das, B; Kumar, R; Mathew, AT; Yadav, AK, 2022) | 0.72 |
| " para-Aminosalicylic acid (PAS), an important second-line agent for treating drug-resistant Mycobacterium tuberculosis, has moderate bioavailability and rapid clearance that necessitate high daily doses of up to 12 g per day, which in turn causes severe gastrointestinal disturbances presumably by disruption of gut microbiota and host epithelial cells." | ( Synthesis and biological evaluation of orally active prodrugs and analogs of para-aminosalicylic acid (PAS). Aldrich, CC; Baughn, AD; Boshoff, HIM; Dartois, V; Hegde, PV; Howe, MD; Jia, Z; Pan, Y; Remache, B; Sharma, S; Zimmerman, MD, 2022) | 0.72 |
| " Postoperatively, the study group had higher bone graft fusion rate, shorter mean bone graft fusion time, and higher paraspinal cyst absorption rate than the control group (P<0." | ( Analysis of efficacy and safety of linezolid-based chemotherapeutic regimens for patients with postoperative multidrug-resistant spinal tuberculosis. Dai, X; Feng, J; Qiao, J; Xia, P; Xu, F; Yang, L, 2022) | 1 |
| " Oxazolidinone antibiotics such as linezolid have excellent oral bioavailability and provide coverage against MRSA infections." | ( The Novel Oxazolidinone TBI-223 Is Effective in Three Preclinical Mouse Models of Methicillin-Resistant Staphylococcus aureus Infection. Archer, NK; Dikeman, DA; Fotouhi, N; Gordon, O; Gough, E; Kaushik, A; Miller, LS; Mumtaz, M; Nuermberger, EL; Orlando, N; Ortines, RV; Patel, AM; Upton, AM; Wang, Y; Youn, C; Zhang, J, 2022) | 1 |
| "This study is an economic analysis seeking to examine cost savings that may be accrued from usage of oral linezolid in place of OPAT IV daptomycin in patients requiring prolonged courses of IV or highly bioavailable oral antibiotic therapy." | ( A cost minimisation analysis comparing oral linezolid and intravenous daptomycin administered via an outpatient parenteral antibiotic therapy programme in patients requiring prolonged antibiotic courses. Faller, E; Jackson, A, 2023) | 1.39 |
A daily dosage of 600 mg of linezolid was well tolerated without stopping treatment in any case. A tedizolid dose of 200 mg/day or 700 mg twice a week is recommended for testing in patients.
| Role | Description |
|---|---|
| antibacterial drug | A drug used to treat or prevent bacterial infections. |
| protein synthesis inhibitor | A compound, usually an anti-bacterial agent or a toxin, which inhibits the synthesis of a protein. |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Class | Description |
|---|---|
| oxazolidinone | An oxazolidine containing one or more oxo groups. |
| morpholines | Any compound containing morpholine as part of its structure. |
| organofluorine compound | An organofluorine compound is a compound containing at least one carbon-fluorine bond. |
| acetamides | Compounds with the general formula RNHC(=O)CH3. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| TDP1 protein | Homo sapiens (human) | Potency | 27.3171 | 0.0008 | 11.3822 | 44.6684 | AID686978; AID686979 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 9.4254 | 0.0013 | 10.1577 | 42.8575 | AID1259253; AID1259255; AID1259256 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 13.3332 | 0.0002 | 29.3054 | 16,493.5996 | AID743079 |
| G | Vesicular stomatitis virus | Potency | 37.9083 | 0.0123 | 8.9648 | 39.8107 | AID1645842 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 35.4813 | 0.0178 | 9.6374 | 44.6684 | AID588834 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 35.4813 | 0.8913 | 12.0676 | 28.1838 | AID1487 |
| Interferon beta | Homo sapiens (human) | Potency | 37.9083 | 0.0033 | 9.1582 | 39.8107 | AID1645842 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 37.9083 | 0.0123 | 8.9648 | 39.8107 | AID1645842 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 37.9083 | 0.0123 | 8.9648 | 39.8107 | AID1645842 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 37.9083 | 0.0123 | 8.9648 | 39.8107 | AID1645842 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 (µMol) | 133.0000 | 0.6315 | 4.4531 | 9.3000 | AID1473740 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 (µMol) | 133.0000 | 0.2000 | 5.6774 | 10.0000 | AID1473741 |
| Voltage-dependent L-type calcium channel subunit alpha-1F | Homo sapiens (human) | IC50 (µMol) | 105.4000 | 0.0003 | 2.6311 | 9.0000 | AID1207747 |
| Bile salt export pump | Homo sapiens (human) | IC50 (µMol) | 566.5000 | 0.1100 | 7.1903 | 10.0000 | AID1449628; AID1473738 |
| 30S ribosomal protein S6 | Escherichia coli K-12 | IC50 (µMol) | 1,150.0000 | 0.0089 | 1.2035 | 5.0000 | AID531644; AID531645 |
| 30S ribosomal protein S7 | Escherichia coli K-12 | IC50 (µMol) | 1,150.0000 | 0.0089 | 1.2035 | 5.0000 | AID531644; AID531645 |
| 50S ribosomal protein L15 | Escherichia coli K-12 | IC50 (µMol) | 1,150.0000 | 0.0089 | 1.2035 | 5.0000 | AID531644; AID531645 |
| Cytochrome P450 1A2 | Homo sapiens (human) | IC50 (µMol) | 20.0000 | 0.0001 | 1.7740 | 10.0000 | AID1056339; AID745377 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 (µMol) | 20.0000 | 0.0001 | 1.7536 | 10.0000 | AID1056336; AID745375 |
| 50S ribosomal protein L10 | Escherichia coli K-12 | IC50 (µMol) | 1,150.0000 | 0.0089 | 1.2035 | 5.0000 | AID531644; AID531645 |
| 50S ribosomal protein L11 | Escherichia coli K-12 | IC50 (µMol) | 1,150.0000 | 0.0089 | 1.2035 | 5.0000 | AID531644; AID531645 |
| 50S ribosomal protein L7/L12 | Escherichia coli K-12 | IC50 (µMol) | 1,150.0000 | 0.0089 | 1.2035 | 5.0000 | AID531644; AID531645 |
| 50S ribosomal protein L19 | Escherichia coli K-12 | IC50 (µMol) | 1,150.0000 | 0.0089 | 1.2035 | 5.0000 | AID531644; AID531645 |
| 50S ribosomal protein L1 | Escherichia coli K-12 | IC50 (µMol) | 1,150.0000 | 0.0089 | 1.2035 | 5.0000 | AID531644; AID531645 |
| 50S ribosomal protein L20 | Escherichia coli K-12 | IC50 (µMol) | 1,150.0000 | 0.0089 | 1.2035 | 5.0000 | AID531644; AID531645 |
| 50S ribosomal protein L27 | Escherichia coli K-12 | IC50 (µMol) | 1,150.0000 | 0.0089 | 1.2035 | 5.0000 | AID531644; AID531645 |
| 50S ribosomal protein L28 | Escherichia coli K-12 | IC50 (µMol) | 1,150.0000 | 0.0089 | 1.2035 | 5.0000 | AID531644; AID531645 |
| 50S ribosomal protein L29 | Escherichia coli K-12 | IC50 (µMol) | 1,150.0000 | 0.0089 | 1.2035 | 5.0000 | AID531644; AID531645 |
| 50S ribosomal protein L31 | Escherichia coli K-12 | IC50 (µMol) | 1,150.0000 | 0.0089 | 1.2035 | 5.0000 | AID531644; AID531645 |
| 50S ribosomal protein L31 type B | Escherichia coli K-12 | IC50 (µMol) | 1,150.0000 | 0.0089 | 1.2035 | 5.0000 | AID531644; AID531645 |
| 50S ribosomal protein L32 | Escherichia coli K-12 | IC50 (µMol) | 1,150.0000 | 0.0089 | 1.2035 | 5.0000 | AID531644; AID531645 |
| 50S ribosomal protein L33 | Escherichia coli K-12 | IC50 (µMol) | 1,150.0000 | 0.0089 | 1.2035 | 5.0000 | AID531644; AID531645 |
| 50S ribosomal protein L34 | Escherichia coli K-12 | IC50 (µMol) | 1,150.0000 | 0.0089 | 1.2035 | 5.0000 | AID531644; AID531645 |
| 50S ribosomal protein L35 | Escherichia coli K-12 | IC50 (µMol) | 1,150.0000 | 0.0089 | 1.2035 | 5.0000 | AID531644; AID531645 |
| 50S ribosomal protein L36 | Escherichia coli K-12 | IC50 (µMol) | 1,150.0000 | 0.0089 | 1.2035 | 5.0000 | AID531644; AID531645 |
| 30S ribosomal protein S10 | Escherichia coli K-12 | IC50 (µMol) | 1,150.0000 | 0.0089 | 1.2035 | 5.0000 | AID531644; AID531645 |
| 30S ribosomal protein S11 | Escherichia coli K-12 | IC50 (µMol) | 1,150.0000 | 0.0089 | 1.2035 | 5.0000 | AID531644; AID531645 |
| 30S ribosomal protein S12 | Escherichia coli K-12 | IC50 (µMol) | 1,150.0000 | 0.0089 | 1.2035 | 5.0000 | AID531644; AID531645 |
| 30S ribosomal protein S13 | Escherichia coli K-12 | IC50 (µMol) | 1,150.0000 | 0.0089 | 1.2035 | 5.0000 | AID531644; AID531645 |
| 30S ribosomal protein S16 | Escherichia coli K-12 | IC50 (µMol) | 1,150.0000 | 0.0089 | 1.2035 | 5.0000 | AID531644; AID531645 |
| 30S ribosomal protein S18 | Escherichia coli K-12 | IC50 (µMol) | 1,150.0000 | 0.0089 | 1.2035 | 5.0000 | AID531644; AID531645 |
| 30S ribosomal protein S19 | Escherichia coli K-12 | IC50 (µMol) | 1,150.0000 | 0.0089 | 1.2035 | 5.0000 | AID531644; AID531645 |
| 30S ribosomal protein S20 | Escherichia coli K-12 | IC50 (µMol) | 1,150.0000 | 0.0089 | 1.2035 | 5.0000 | AID531644; AID531645 |
| 30S ribosomal protein S2 | Escherichia coli K-12 | IC50 (µMol) | 1,150.0000 | 0.0089 | 1.2035 | 5.0000 | AID531644; AID531645 |
| 30S ribosomal protein S3 | Escherichia coli K-12 | IC50 (µMol) | 1,150.0000 | 0.0089 | 1.2035 | 5.0000 | AID531644; AID531645 |
| 30S ribosomal protein S4 | Escherichia coli K-12 | IC50 (µMol) | 1,150.0000 | 0.0089 | 1.2035 | 5.0000 | AID531644; AID531645 |
| 30S ribosomal protein S5 | Escherichia coli K-12 | IC50 (µMol) | 1,150.0000 | 0.0089 | 1.2035 | 5.0000 | AID531644; AID531645 |
| 30S ribosomal protein S8 | Escherichia coli K-12 | IC50 (µMol) | 1,150.0000 | 0.0089 | 1.2035 | 5.0000 | AID531644; AID531645 |
| 30S ribosomal protein S9 | Escherichia coli K-12 | IC50 (µMol) | 1,150.0000 | 0.0089 | 1.2035 | 5.0000 | AID531644; AID531645 |
| 50S ribosomal protein L13 | Escherichia coli K-12 | IC50 (µMol) | 1,150.0000 | 0.0089 | 1.2035 | 5.0000 | AID531644; AID531645 |
| 50S ribosomal protein L14 | Escherichia coli K-12 | IC50 (µMol) | 1,150.0000 | 0.0089 | 1.2035 | 5.0000 | AID531644; AID531645 |
| 50S ribosomal protein L16 | Escherichia coli K-12 | IC50 (µMol) | 1,150.0000 | 0.0089 | 1.2035 | 5.0000 | AID531644; AID531645 |
| 50S ribosomal protein L23 | Escherichia coli K-12 | IC50 (µMol) | 1,150.0000 | 0.0089 | 1.2035 | 5.0000 | AID531644; AID531645 |
| 30S ribosomal protein S15 | Escherichia coli K-12 | IC50 (µMol) | 1,150.0000 | 0.0089 | 1.2035 | 5.0000 | AID531644; AID531645 |
| DNA gyrase subunit A | Escherichia coli K-12 | IC50 (µMol) | 32.0000 | 0.0239 | 0.5629 | 5.2300 | AID1167728 |
| DNA gyrase subunit B | Escherichia coli K-12 | IC50 (µMol) | 32.0000 | 0.0050 | 0.4398 | 5.2300 | AID1167728 |
| 50S ribosomal protein L17 | Escherichia coli K-12 | IC50 (µMol) | 1,150.0000 | 0.0089 | 1.2035 | 5.0000 | AID531644; AID531645 |
| 50S ribosomal protein L21 | Escherichia coli K-12 | IC50 (µMol) | 1,150.0000 | 0.0089 | 1.2035 | 5.0000 | AID531644; AID531645 |
| 50S ribosomal protein L30 | Escherichia coli K-12 | IC50 (µMol) | 1,150.0000 | 0.0089 | 1.2035 | 5.0000 | AID531644; AID531645 |
| 50S ribosomal protein L6 | Escherichia coli K-12 | IC50 (µMol) | 1,150.0000 | 0.0089 | 1.2035 | 5.0000 | AID531644; AID531645 |
| 30S ribosomal protein S14 | Escherichia coli K-12 | IC50 (µMol) | 1,150.0000 | 0.0089 | 1.2035 | 5.0000 | AID531644; AID531645 |
| 30S ribosomal protein S17 | Escherichia coli K-12 | IC50 (µMol) | 1,150.0000 | 0.0089 | 1.2035 | 5.0000 | AID531644; AID531645 |
| 30S ribosomal protein S1 | Escherichia coli K-12 | IC50 (µMol) | 1,150.0000 | 0.0089 | 1.2035 | 5.0000 | AID531644; AID531645 |
| 50S ribosomal protein L18 | Escherichia coli K-12 | IC50 (µMol) | 1,150.0000 | 0.0089 | 1.2035 | 5.0000 | AID531644; AID531645 |
| Cytochrome P450 2D6 | Homo sapiens (human) | IC50 (µMol) | 20.0000 | 0.0000 | 2.0151 | 10.0000 | AID1056337; AID745376 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 (µMol) | 20.0000 | 0.0000 | 2.8005 | 10.0000 | AID1056338; AID745378 |
| Amine oxidase [flavin-containing] B | Rattus norvegicus (Norway rat) | IC50 (µMol) | 17.0000 | 0.0004 | 0.7649 | 12.5000 | AID126688 |
| Amine oxidase [flavin-containing] A | Homo sapiens (human) | IC50 (µMol) | 46.0000 | 0.0000 | 2.3789 | 9.7700 | AID1265126 |
| Amine oxidase [flavin-containing] A | Homo sapiens (human) | Ki | 33.9750 | 0.0019 | 2.3797 | 10.0000 | AID292903; AID303963; AID319168; AID751392 |
| Prostaglandin G/H synthase 1 | Homo sapiens (human) | IC50 (µMol) | 8.1900 | 0.0002 | 1.5574 | 10.0000 | AID1553385 |
| Amine oxidase [flavin-containing] B | Homo sapiens (human) | IC50 (µMol) | 9.5500 | 0.0000 | 1.8914 | 9.5700 | AID1265127; AID434137 |
| Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | Homo sapiens (human) | IC50 (µMol) | 8.1900 | 8.1900 | 8.1900 | 8.1900 | AID1553386 |
| Cytochrome P450 2C19 | Homo sapiens (human) | Ki | 53.0000 | 0.0001 | 0.8300 | 10.0000 | AID303963 |
| 50S ribosomal protein L2 | Escherichia coli K-12 | IC50 (µMol) | 1,150.0000 | 0.0089 | 1.2035 | 5.0000 | AID531644; AID531645 |
| 50S ribosomal protein L3 | Escherichia coli K-12 | IC50 (µMol) | 1,150.0000 | 0.0089 | 1.2035 | 5.0000 | AID531644; AID531645 |
| 50S ribosomal protein L24 | Escherichia coli K-12 | IC50 (µMol) | 1,150.0000 | 0.0089 | 1.2035 | 5.0000 | AID531644; AID531645 |
| 50S ribosomal protein L4 | Escherichia coli K-12 | IC50 (µMol) | 1,150.0000 | 0.0089 | 1.2035 | 5.0000 | AID531644; AID531645 |
| 50S ribosomal protein L22 | Escherichia coli K-12 | IC50 (µMol) | 1,150.0000 | 0.0089 | 1.2035 | 5.0000 | AID531644; AID531645 |
| 50S ribosomal protein L5 | Escherichia coli K-12 | IC50 (µMol) | 1,150.0000 | 0.0089 | 1.2035 | 5.0000 | AID531644; AID531645 |
| 30S ribosomal protein S21 | Escherichia coli K-12 | IC50 (µMol) | 1,150.0000 | 0.0089 | 1.2035 | 5.0000 | AID531644; AID531645 |
| 50S ribosomal protein L25 | Escherichia coli K-12 | IC50 (µMol) | 1,150.0000 | 0.0089 | 1.2035 | 5.0000 | AID531644; AID531645 |
| Voltage-dependent L-type calcium channel subunit alpha-1D | Homo sapiens (human) | IC50 (µMol) | 105.4000 | 0.0003 | 2.5955 | 9.0000 | AID1207747 |
| Voltage-dependent L-type calcium channel subunit alpha-1S | Homo sapiens (human) | IC50 (µMol) | 105.4000 | 0.0003 | 2.6311 | 9.0000 | AID1207747 |
| Voltage-dependent L-type calcium channel subunit alpha-1C | Homo sapiens (human) | IC50 (µMol) | 105.4000 | 0.0003 | 2.2545 | 9.6000 | AID1207747 |
| 50S ribosomal protein L36 2 | Escherichia coli K-12 | IC50 (µMol) | 1,150.0000 | 0.0089 | 1.2035 | 5.0000 | AID531644; AID531645 |
| Dual specificity tyrosine-phosphorylation-regulated kinase 1A | Mus musculus (house mouse) | IC50 (µMol) | 20.0000 | 0.0120 | 2.5060 | 5.0000 | AID1056337 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 (µMol) | 133.0000 | 2.4100 | 6.3433 | 10.0000 | AID1473739 |
| Renin | Callithrix jacchus (white-tufted-ear marmoset) | IC50 (µMol) | 17.0000 | 0.0800 | 3.1267 | 6.7000 | AID434137 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| streptokinase A precursor | Streptococcus pyogenes M1 GAS | EC50 (µMol) | 3.0780 | 0.0600 | 8.9128 | 130.5170 | AID1902; AID1914 |
| Estrogen receptor | Rattus norvegicus (Norway rat) | EC50 (µMol) | 5.9980 | 0.0060 | 22.3670 | 130.5170 | AID1914 |
| Estrogen receptor beta | Rattus norvegicus (Norway rat) | EC50 (µMol) | 5.9980 | 0.0060 | 22.3670 | 130.5170 | AID1914 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Cytochrome P450 1A2 | Homo sapiens (human) | INH | 100.0000 | 0.1000 | 0.1000 | 0.1000 | AID1553380 |
| Cytochrome P450 3A4 | Homo sapiens (human) | INH | 100.0000 | 1.7000 | 2.8500 | 4.0000 | AID1553384 |
| Cytochrome P450 2D6 | Homo sapiens (human) | INH | 100.0000 | 3.2000 | 3.4000 | 3.6000 | AID1553383 |
| Cytochrome P450 2C9 | Homo sapiens (human) | INH | 100.0000 | 4.4000 | 7.0000 | 9.1000 | AID1553381 |
| Cytochrome P450 2C19 | Homo sapiens (human) | INH | 100.0000 | 7.0000 | 7.0000 | 7.0000 | AID1553382 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1745854 | NCATS anti-infectives library activity on HEK293 viability as a counter-qHTS vs the C. elegans viability qHTS | 2023 | Disease models & mechanisms, 03-01, Volume: 16, Issue:3 | In vivo quantitative high-throughput screening for drug discovery and comparative toxicology. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5 | A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1 | Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5 | A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347411 | qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS Mechanism Interrogation Plate v5.0 (MIPE) Libary | 2020 | ACS chemical biology, 07-17, Volume: 15, Issue:7 | High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle. |
| AID1347160 | Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 | Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347159 | Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 | Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID535021 | Antimicrobial activity against vancomycin intermediate Staphylococcus aureus NRS-18 expressing SCCmec type 2 element by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | In vitro activity of ceftaroline against community-associated methicillin-resistant, vancomycin-intermediate, vancomycin-resistant, and daptomycin-nonsusceptible Staphylococcus aureus isolates. |
| AID1692904 | Antibacterial activity against vancomycin-resistant Enterococcus faecium | 2021 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 32 | Design, synthesis and antibacterial evaluation of novel oxazolidinone derivatives nitrogen-containing fused heterocyclic moiety. |
| AID406621 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae isolates by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Prevalence, characteristics, and molecular epidemiology of macrolide and fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae at five tertiary-care hospitals in Korea. |
| AID548473 | Antibacterial activity against vancomycin-susceptible Staphylococcus aureus Mu50omega expressing vraSn mutant gene after 48 hrs by Etest | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Contribution of vraSR and graSR point mutations to vancomycin resistance in vancomycin-intermediate Staphylococcus aureus. |
| AID285132 | Antimicrobial activity against viridans group Streptococcus sanguinis at 0.25 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID523796 | Antimicrobial activity against oxacillin-resistant coagulase-negative Staphylococcus aureus assessed as percent susceptible strain by CLSI method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative activities of TR-700 (torezolid) against staphylococcal blood isolates collected in Spain. |
| AID308919 | Antibacterial activity against multidrug resistant Enterococcus faecalis ATCC 700802 by broth microdilution method | 2007 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 17, Issue:18 | Synthesis and in vitro antibacterial activity of novel methylamino piperidinyl oxazolidinones. |
| AID516167 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus clinical isolates assessed as resistant isolates by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | In vitro activity of telavancin against a contemporary worldwide collection of Staphylococcus aureus isolates. |
| AID429417 | Antibacterial activity against Staphylococcus aureus ATCC 25923 by agar dilution method in presence of human plasma | 2009 | European journal of medicinal chemistry, Aug, Volume: 44, Issue:8 | Synthesis and antibacterial activity of novel 5-(4-methyl-1H-1,2,3-triazole) methyl oxazolidinones. |
| AID531561 | Antibacterial activity against coagulase-negative Staphylococcus sciuri obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID523778 | Antimicrobial activity against oxacillin-susceptible Staphylococcus aureus by CLSI method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative activities of TR-700 (torezolid) against staphylococcal blood isolates collected in Spain. |
| AID1167993 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis clinical isolate 7079 after overnight incubation by two-fold serial dilution method | 2014 | Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21 | Synthesis and biological evaluation of novel peptide BF2 as an antibacterial agent against clinical isolates of vancomycin-resistant enterococci. |
| AID582991 | Antimicrobial activity against glycopeptide-resistant Enterococcus faecalis isolate HS08369 harboring MLST sequence type ST18 and pulsotype G expressing vanM gene cluster isolated from urine of patient by Etest | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | vanM, a new glycopeptide resistance gene cluster found in Enterococcus faecium. |
| AID1852684 | Antibacterial activity against wild type Pseudomonas aeruginosa assessed as inhibition of bacterial growth | |||
| AID369446 | Antimicrobial activity against Streptococcus group A after 20 to 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vitro activity of telavancin against gram-positive clinical isolates recently obtained in Europe. |
| AID561245 | Antibacterial activity against methicillin-resistant Staphylococcus epidermidis by CLSI M100-S17 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | AFN-1252, a FabI inhibitor, demonstrates a Staphylococcus-specific spectrum of activity. |
| AID523046 | Antimicrobial activity against Moraxella catarrhalis by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative in vitro antimicrobial activities of torezolid (TR-700), the active moiety of a new oxazolidinone, torezolid phosphate (TR-701), determination of tentative disk diffusion interpretive criteria, and quality control ranges. |
| AID571990 | Antibacterial activity against Ruminococcus torques by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID1649290 | Antibacterial activity against Vancomycin-resistant Enterococcus faecium SRM1101 (c_VanB) assessed as inhibition of bacterial growth incubated for 20 hrs by microdilution broth method | |||
| AID520521 | Oral bioavailability in osteomylitic patient | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Efficacies of ceftobiprole medocaril and comparators in a rabbit model of osteomyelitis due to methicillin-resistant Staphylococcus aureus. |
| AID558532 | Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus 1287 measured on day 35 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID1265136 | Inhibition of human recombinant MAO-B using p-tyramine as substrate at 50 to 200 uM measured up to 50 mins by ELISA screening analysis | 2015 | European journal of medicinal chemistry, Dec-01, Volume: 106 | Synthesis and biological evaluation of novel 5-(hydroxamic acid)methyl oxazolidinone derivatives. |
| AID564811 | Antimicrobial activity against methicillin-resistant coagulase-negative Staphylococcus haemolyticus assessed as susceptible isolates after 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID285138 | Antimicrobial activity against viridans group Streptococcus vestibularis at 0.25 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID523040 | Antimicrobial activity against penicillin-susceptible Streptococcus pneumoniae by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative in vitro antimicrobial activities of torezolid (TR-700), the active moiety of a new oxazolidinone, torezolid phosphate (TR-701), determination of tentative disk diffusion interpretive criteria, and quality control ranges. |
| AID542919 | Antimicrobial activity against Bacillus anthracis infected in in vitro hollow fiber PK/PD model assessed as cell killing at 800 mg administered once every 24 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID576132 | Antibacterial activity against 10'4 to 10'5 CFU Haemophilus influenzae after 18 hrs by CLSI 2-fold agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | In vitro and in vivo activities of LCB01-0371, a new oxazolidinone. |
| AID244888 | Minimal inhibitory concentration against Escherichia coli ATCC 25922 | 2004 | Bioorganic & medicinal chemistry letters, Sep-20, Volume: 14, Issue:18 | Synthesis and antibacterial activity of some aryloxy/thioaryloxy oxazolidinone derivatives. |
| AID520025 | Antimicrobial activity against Enterococcus faecalis A7789 | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID1680007 | Induction of outer membrane permeabilization in Escherichia coli ATCC 25922 at 20 ug/ml measured for 12 mins by NPN dye based fluorescence assay | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Synthesis and antibacterial bioactivities of cationic deacetyl linezolid amphiphiles. |
| AID531579 | Antibacterial activity against Micrococcus spp. obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID284977 | Antimicrobial activity against Corynebacterium striatum at 0.12 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID1304851 | Ratio of MIC for methicillin-resistant Staphylococcus aureus clinical isolate 2 in absence and presence of Cu2+ | 2016 | Journal of medicinal chemistry, 04-28, Volume: 59, Issue:8 | Structure-Activity Relationships of a Diverse Class of Halogenated Phenazines That Targets Persistent, Antibiotic-Tolerant Bacterial Biofilms and Mycobacterium tuberculosis. |
| AID1390481 | Antibacterial activity against vancomycin-resistant Enterococcus faecium 03080 DS | 2018 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 28, Issue:7 | Design, synthesis and biological evaluation of spiropyrimidinetriones oxazolidinone derivatives as antibacterial agents. |
| AID1904916 | Antibacterial activity against methicillin-resistant Staphylococcus aureus NRS 123 (USA400) incubated for 18 to 20 hrs by broth microdilution method | 2022 | European journal of medicinal chemistry, Apr-15, Volume: 234 | Exploring the structure-activity relationships of diphenylurea as an antibacterial scaffold active against methicillin- and vancomycin-resistant Staphylococcus aureus. |
| AID576873 | Bactericidal activity against 0.5 hrs peripheral compartment culture samples of Enterococcus faecalis Ef1497 MutM3 in two-compartment pharmacokinetic/pharmacodynamic model assessed as effect on bacterial count at 600 mg, bid administered as 0.5 hr infusio | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID283160 | Antimicrobial susceptibility of Staphylococcus lugdunensis IDRL2554 biofilms after 24 hrs assessed as bacterial regrowth | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | In vitro effects of antimicrobial agents on planktonic and biofilm forms of Staphylococcus lugdunensis clinical isolates. |
| AID289866 | Antibacterial activity against Enterococcus faecalis ATCC 29212 | 2007 | European journal of medicinal chemistry, Apr, Volume: 42, Issue:4 | Synthesis, SAR and antibacterial studies on novel chalcone oxazolidinone hybrids. |
| AID576140 | Antibacterial activity against 10'4 to 10'5 CFU methicillin-susceptible coagulase-negative Staphylococcus after 18 hrs by CLSI 2-fold agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | In vitro and in vivo activities of LCB01-0371, a new oxazolidinone. |
| AID1168018 | Antibacterial activity against vancomycin-resistant Enterococcus faecium clinical isolate 147969 after overnight incubation by two-fold serial dilution method | 2014 | Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21 | Synthesis and biological evaluation of novel peptide BF2 as an antibacterial agent against clinical isolates of vancomycin-resistant enterococci. |
| AID519139 | Antimicrobial activity against community-acquired methicillin resistant Staphylococcus aureus expressing PVL gene and mec type IV gene assessed as susceptible strains by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Antimicrobial activities of Ceftaroline and ME1036 tested against clinical strains of community-acquired methicillin-resistant Staphylococcus aureus. |
| AID267722 | Antimicrobial activity against Enterococcus faecium UC12712 | 2006 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 16, Issue:13 | Synthesis and structure-activity studies of antibacterial oxazolidinones containing dihydrothiopyran or dihydrothiazine C-rings. |
| AID285376 | Bactericidal activity against heteroresistant vancomycin-intermediate Staphylococcus aureus Mu3 assessed as reduction of CFU using in vitro PK/PD model with human dosage regimen 600 mg every 12 hrs after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Pharmacokinetic/pharmacodynamic factors influencing emergence of resistance to linezolid in an in vitro model. |
| AID369675 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus Smith infected in C3H mouse assessed as mortality at 6.25 mg/kg/day, po administered within 15 mins of infection measured after 48 hrs by organ burden assay relative to control | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vivo efficacy of a novel oxazolidinone compound in two mouse models of infection. |
| AID1698704 | Antibacterial activity against Vancomycin-resistant Enterococcus by CLSI method | 2020 | Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22 | Lead optimization of 8-(methylamino)-2-oxo-1,2-dihydroquinolines as bacterial type II topoisomerase inhibitors. |
| AID283639 | Antimicrobial activity against Staphylococcus aureus ST/02/2121 with 23S rRNA T2504C mutation | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | In vitro activity of the oxazolidinone RWJ-416457 against linezolid-resistant and -susceptible staphylococci and enterococci. |
| AID566569 | Antimicrobial activity against Bacillus subtilis PTCC 1023 by conventional agar-dilution method | 2011 | European journal of medicinal chemistry, Jan, Volume: 46, Issue:1 | Discovery of a novel nitroimidazolyl-oxazolidinone hybrid with potent anti Gram-positive activity: Synthesis and antibacterial evaluation. |
| AID571799 | Antibacterial activity against Clostridium bifermentans by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID583881 | Antibacterial activity against laboratory-derived Staphylococcus aureus isolate 29213-3 harboring ribosomal protein L3 deltaPhe127-His146 mutant and cfr-containing p42262 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Elevated linezolid resistance in clinical cfr-positive Staphylococcus aureus isolates is associated with co-occurring mutations in ribosomal protein L3. |
| AID318352 | Antibacterial activity against Staphylococcus aureus in presence of serum | 2007 | Proceedings of the National Academy of Sciences of the United States of America, May-01, Volume: 104, Issue:18 | Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties. |
| AID1778647 | Antibacterial activity against vancomycin-susceptible Enterococcus faecalis ATCC 29212 assessed as bacterial growth inhibition incubated for 24 hrs by CLSI protocol based broth microdilution method | 2021 | European journal of medicinal chemistry, Oct-05, Volume: 221 | Design, synthesis and evaluation of novel 9-arylalkyl-10-methylacridinium derivatives as highly potent FtsZ-targeting antibacterial agents. |
| AID439889 | Antibacterial activity against Staphylococcus epidermidis ATCC 12229 after 18 hrs by agar dilution method | 2010 | European journal of medicinal chemistry, Jan, Volume: 45, Issue:1 | Synthesis and antibacterial activity of isothiazolyl oxazolidinones and analogous 3(2H)-isothiazolones. |
| AID369441 | Antibacterial activity against vancomycin-susceptible Enterococcus faecium after 20 to 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vitro activity of telavancin against gram-positive clinical isolates recently obtained in Europe. |
| AID1770355 | Bactericidal activity against penicillin-susceptible Bacillus pumilus CMCC63202 assessed as inhibition of bacterial growth measured after 20 hrs by two-fold microdilution assay | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Modification of 5-methylphenanthridium from benzothiazoles to indoles as potent FtsZ inhibitors: Broadening the antibacterial spectrum toward vancomycin-resistant enterococci. |
| AID571803 | Antibacterial activity against Clostridium glycolicum by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID1327122 | Antitubercular activity against dormant stage Mycobacterium bovis BCG ATCC 35734 at 3 ug/ml measured after 12 days by nitrate reductase assay | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Design, synthesis and biological evaluation of novel azaspiro analogs of linezolid as antibacterial and antitubercular agents. |
| AID573143 | Antibacterial activity against penicillin-susceptible Streptococcus viridans by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID575050 | AUC (12 hrs) in liver transplant patient plasma at 600 mg, iv or 600 mg, po administered every 12 hrs by HPLC | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Therapeutic drug monitoring of linezolid: a retrospective monocentric analysis. |
| AID68244 | In vitro antibacterial activity against vancomycin-resistant Enterococcus faecium C6487 (VRE). | 1999 | Bioorganic & medicinal chemistry letters, Sep-20, Volume: 9, Issue:18 | Synthesis and in vitro activity of new oxazolidinone antibacterial agents having substituted isoxazoles. |
| AID1312945 | Bactericidal activity against methicillin-sensitive Staphylococcus aureus NRS72 clinical isolate after 20 hrs by broth microdilution method | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10 | Second-Generation Phenylthiazole Antibiotics with Enhanced Pharmacokinetic Properties. |
| AID373310 | Antibacterial activity against methicillin-resistant coagulase-negative Staphylococcus clinical isolate after 18 hrs by NCCLS M7-A4 method | 2009 | European journal of medicinal chemistry, Mar, Volume: 44, Issue:3 | Synthesis, antibacterial and anticonvulsant evaluations of some cyclic enaminones. |
| AID575269 | Antimicrobial activity against vancomycin-susceptible Enterococcus faecium by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Comparative in vitro activity profiles of novel bis-indole antibacterials against gram-positive and gram-negative clinical isolates. |
| AID1139109 | Antimicrobial activity against Staphylococcus aureus in rat thigh assessed as log reduction of CFU at 3 mg/kg, iv after 8 hrs | 2014 | Bioorganic & medicinal chemistry letters, May-01, Volume: 24, Issue:9 | Successful application of serum shift prediction models to the design of dual targeting inhibitors of bacterial gyrase B and topoisomerase IV with improved in vivo efficacy. |
| AID458460 | Antimicrobial activity against Mycobacterium vaccae IMET 10670 at 2 mM after overnight incubation by agar diffusion method | 2010 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 20, Issue:3 | Syntheses and antibacterial activity studies of new oxazolidinones from nitroso Diels-Alder chemistry. |
| AID533984 | Bacteriostatic activity against linezolid-susceptible Staphylococcus aureus NRS384 infected in THP1 cells after 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Cellular pharmacodynamics of the novel biaryloxazolidinone radezolid: studies with infected phagocytic and nonphagocytic cells, using Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Legionella pneumophila. |
| AID585161 | Antibacterial activity against Mycobacterium smegmatis harboring 23S rRNA A2503G mutant after 24 generation times | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Mutations in 23S rRNA at the peptidyl transferase center and their relationship to linezolid binding and cross-resistance. |
| AID561340 | Antibacterial activity against Methicillin-sensitive Staphylococcus aureus by CLSI broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Potency and bactericidal activity of iclaprim against recent clinical gram-positive isolates. |
| AID1308231 | Antibacterial activity against Streptococcus oralis ATCC 9811 incubated for 16 to 20 hrs by microdilution method | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10 | Structure-Activity Relationship for the 4(3H)-Quinazolinone Antibacterials. |
| AID1680054 | Antibacterial activity against carbapenem-resistant Klebsiella pneumoniae clinical isolate 2 assessed as reduction in bacterial growth incubated for 16 to 20 hrs by CLSI-based broth microdilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Synthesis and antibacterial bioactivities of cationic deacetyl linezolid amphiphiles. |
| AID373995 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus 547 after 48 passages with Linezolid measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID1079945 | Animal toxicity known. [column 'TOXIC' in source] | |||
| AID573868 | Antibacterial activity against penicillin-susceptible Streptococcus pneumoniae ATCC 6301 infected in po dosed Swiss Webster mouse administered at 1 to 3 hrs post infection measured after 3 days | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | In vivo activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. |
| AID1151777 | Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate 0605 in mouse thigh infection model assessed as reduction of log10 CFU per thigh at 10 mg/kg, po | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID1400754 | Antibacterial activity against vancomycin-resistant Enterococcus faecium ATCC 700221 after 16 to 18 hrs by broth microdilution method | 2017 | MedChemComm, Apr-01, Volume: 8, Issue:4 | Microwave-enhanced Friedländer synthesis for the rapid assembly of halogenated quinolines with antibacterial and biofilm eradication activities against drug resistant and tolerant bacteria. |
| AID1832945 | Antibacterial activity against Vanomycin-resistant Enterococcus faecium NCTC 12204 assessed as reduction in bacterial growth incubated for 20 hrs by microplate reader method | 2021 | Bioorganic & medicinal chemistry, 11-01, Volume: 49 | Synthesis, microbiological evaluation and structure activity relationship analysis of linezolid analogues with different C5-acylamino substituents. |
| AID572012 | Antibacterial activity against Prevotella buccae by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID523039 | Antimicrobial activity against Streptococcus pneumoniae by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative in vitro antimicrobial activities of torezolid (TR-700), the active moiety of a new oxazolidinone, torezolid phosphate (TR-701), determination of tentative disk diffusion interpretive criteria, and quality control ranges. |
| AID562251 | Antibacterial activity against methicillin-resistant Staphylococcus aureus isolated form patient blood measured after 18 to 24 hrs on day 1 post isolation by Etest | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Correlation between vancomycin MIC values and those of other agents against gram-positive bacteria among patients with bloodstream infections caused by methicillin-resistant Staphylococcus aureus. |
| AID576643 | Bactericidal activity against 12.5 hrs peripheral compartment culture samples of Staphylococcus aureus RN4220 MutS2 in two-compartment pharmacokinetic/pharmacodynamic model assessed as effect on bacterial count at 600 mg, bid administered as 0.5 hr infusi | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID561266 | Antibacterial activity against Enterococcus faecium assessed as susceptible isolates by CLSI M100-S17 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | AFN-1252, a FabI inhibitor, demonstrates a Staphylococcus-specific spectrum of activity. |
| AID304010 | Antibacterial activity against methicillin-resistant Staphylococcus aureus C203 in po dosed CD1 mouse systemic infection model assessed as mortality after 7 days | 2007 | Journal of medicinal chemistry, Nov-29, Volume: 50, Issue:24 | Antibacterial oxazolidinones possessing a novel C-5 side chain. (5R)-trans-3-[3-Fluoro-4- (1-oxotetrahydrothiopyran-4-yl)phenyl]-2- oxooxazolidine-5-carboxylic acid amide (PF-00422602), a new lead compound. |
| AID609062 | Antibacterial activity against Staphylococcus aureus ATCC 9144 at 1 mg/ml after 24 hrs by agar-well diffusion technique | 2011 | European journal of medicinal chemistry, Jul, Volume: 46, Issue:7 | A regioselective synthesis of some new pyrazol-1'-ylpyrazolo[1,5-a]pyrimidines in aqueous medium and their evaluation as antimicrobial agents. |
| AID559784 | Antimicrobial activity against vancomycin-susceptible Staphylococcus aureus by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID729178 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus ATCC 19636 infected in po dosed systemic infection mouse model administered 1 hr post infection measured after 48 hrs | 2013 | Journal of medicinal chemistry, Mar-28, Volume: 56, Issue:6 | Solubility-driven optimization of (pyridin-3-yl) benzoxazinyl-oxazolidinones leading to a promising antibacterial agent. |
| AID576417 | Volume of distribution at steady state in two-compartment pharmacokinetic/pharmacodynamic model at 200 mg, bid administered as 0.5 hrs infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID1596545 | Antibacterial activity against methicillin-resistant Staphylococcus aureus USA300 assessed as reduction in bacterial cell growth incubated for 18 to 20 hrs by broth microdilution method | 2019 | European journal of medicinal chemistry, Aug-01, Volume: 175 | Lipophilic efficient phenylthiazoles with potent undecaprenyl pyrophosphatase inhibitory activity. |
| AID255572 | In vitro minimum inhibitory concentration against Staphylococcus aureus ATCC 25923 after incubation in air at 35 degree C for 24 hr using agar dilution method | 2005 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 15, Issue:19 | Synthesis and SAR of novel oxazolidinones: discovery of ranbezolid. |
| AID1539456 | Antibacterial activity against cephalosporin-resistant Streptococcus pneumoniae ATCC 51916 clinical isolates after 18 to 20 hrs by CLSI-based broth microdilution assay | |||
| AID555307 | Antibacterial activity against methicillin-susceptible coagulase-negative Staphylococcus epidermidis 057 by broth macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Antistaphylococcal activity of dihydrophthalazine antifolates, a family of novel antibacterial drugs. |
| AID562395 | Antimicrobial activity against Staphylococcus epidermidis clinical isolates assessed as percent susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID730748 | Antibacterial activity against macrolides, lincosamides, streptogramin B and methicillin-resistant Staphylococcus epidermidis 1105-00 assessed as growth inhibition | 2013 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 23, Issue:6 | Novel 3-O-carbamoyl erythromycin A derivatives (carbamolides) with activity against resistant staphylococcal and streptococcal isolates. |
| AID373997 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus 547 after 50 passages with vancomycin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID1390485 | Antibacterial activity against vancomycin-resistant Enterococcus faecium 134 | 2018 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 28, Issue:7 | Design, synthesis and biological evaluation of spiropyrimidinetriones oxazolidinone derivatives as antibacterial agents. |
| AID562386 | Antimicrobial activity against Enterococcus faecalis expressing VanA gene clinical isolates assessed as percent susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID548255 | Antibacterial activity against vancomycin-susceptible Staphylococcus aureus Mu50omega expressing vraSn mutant gene after 24 hrs by Etest | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Contribution of vraSR and graSR point mutations to vancomycin resistance in vancomycin-intermediate Staphylococcus aureus. |
| AID576866 | Bactericidal activity against 2 hrs peripheral compartment culture samples of Enterococcus faecalis Ef1497 MutM3 in two-compartment pharmacokinetic/pharmacodynamic model assessed as effect on bacterial count at 200 mg, bid administered as 0.5 hr infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID531571 | Antibacterial activity against Streptococcus constellatus obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID249176 | Protective dose against Staphylococcus aureus in mice after 8 days of oral b.i.d. administration at 1 and 5 h per interval with water as vehicle (n=10); range is 5-6 mg/kg/day | 2005 | Bioorganic & medicinal chemistry letters, Jun-02, Volume: 15, Issue:11 | Biaryl isoxazolinone antibacterial agents. |
| AID534791 | Bactericidal activity against vancomycin-resistant Staphylococcus aureus assessed as antibiotic concentration that reduced the number of viable cells by =>99.9% by colony count method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | In vitro activity of ceftaroline against community-associated methicillin-resistant, vancomycin-intermediate, vancomycin-resistant, and daptomycin-nonsusceptible Staphylococcus aureus isolates. |
| AID571994 | Antibacterial activity against Finegoldia magna by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID1400034 | Bactericidal activity against replicating Mycobacterium tuberculosis H37Rv incubated for 15 days under aerobic condition by MABA | 2018 | Bioorganic & medicinal chemistry, 09-15, Volume: 26, Issue:17 | An antimycobacterial pleuromutilin analogue effective against dormant bacilli. |
| AID524723 | Antibacterial activity against linezolid-resistant Enterococcus faecium 03B1077 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro antibacterial activity of CE-156811, a novel analog derived from hygromycin A. |
| AID695443 | Antibacterial activity against fluoroquinolone resistant Staphylococcus aureus 2-FQR2M NY2746 expressing GyrA Ser84Leu mutant and GrlA Ser80Phe mutant | 2011 | Journal of medicinal chemistry, May-12, Volume: 54, Issue:9 | Selenophene-containing inhibitors of type IIA bacterial topoisomerases. |
| AID475000 | Antibacterial activity against Enterococcus faecalis LCB0005 by two fold serial dilution method | 2010 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 20, Issue:7 | Synthesis, crystal and antibacterial studies of diversely functionalized tetrahydropyridin-4-ol. |
| AID477372 | Antibacterial activity against fmethicillin and vancomycin-resistant Staphylococcus aureus ATCC 29213 after 24 hrs | 2009 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13 | Synthesis and antibacterial evaluation of isoxazolinyl oxazolidinones: Search for potent antibacterial. |
| AID511384 | Antibacterial activity against Enterococcus faecium by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Comparative in vitro activities of nemonoxacin (TG-873870), a novel nonfluorinated quinolone, and other quinolones against clinical isolates. |
| AID524958 | Antibacterial activity against methicillin-resistant coagulase-negative Staphylococcus haemolyticus clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Comparative surveillance study of telavancin activity against recently collected gram-positive clinical isolates from across the United States. |
| AID1197132 | Antibacterial activity against Enterococcus faecium NCTC 7171 after 16 to 20 hrs by broth microdilution method | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3 | Structure-activity relationship for the oxadiazole class of antibiotics. |
| AID1504622 | Antibacterial activity against Enterococcus faecium 19434 by microbroth dilution method | 2017 | ACS medicinal chemistry letters, Nov-09, Volume: 8, Issue:11 | Design, Synthesis, and Antibacterial Evaluation of Oxazolidinones with Fused Heterocyclic C-Ring Substructure. |
| AID1862431 | Antibacterial activity against methicillin-resistant Staphylococcus aureus USA 300 (ARLG 1663) assessed as reduction in visible bacterial growth incubated for 18 to 20 hrs by CLSI based broth microdilution analysis | 2022 | European journal of medicinal chemistry, Oct-05, Volume: 240 | Membrane acting Povarov-Doebner derived compounds potently disperse preformed multidrug resistant Gram-positive bacterial biofilms. |
| AID524974 | Antibacterial activity against Streptococcus sp. Group C clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Comparative surveillance study of telavancin activity against recently collected gram-positive clinical isolates from across the United States. |
| AID533417 | Antimicrobial activity against Micromonas micros by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activities of doripenem, a new broad-spectrum carbapenem, against recently collected clinical anaerobic isolates, with emphasis on the Bacteroides fragilis group. |
| AID520021 | Antimicrobial activity against Enterococcus faecalis ATCC 29212-P5 harboring G2576U mutation in 23S rRNA | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID523037 | Antimicrobial activity against vancomycin-susceptible Enterococcus faecium by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative in vitro antimicrobial activities of torezolid (TR-700), the active moiety of a new oxazolidinone, torezolid phosphate (TR-701), determination of tentative disk diffusion interpretive criteria, and quality control ranges. |
| AID1400752 | Antibacterial activity against methicillin-resistant Staphylococcus epidermidis ATCC 35984 after 16 to 18 hrs by broth microdilution method | 2017 | MedChemComm, Apr-01, Volume: 8, Issue:4 | Microwave-enhanced Friedländer synthesis for the rapid assembly of halogenated quinolines with antibacterial and biofilm eradication activities against drug resistant and tolerant bacteria. |
| AID278569 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus ATCC 29213 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | In vitro activities of the lipopeptides palmitoyl (Pal)-Lys-Lys-NH(2) and Pal-Lys-Lys alone and in combination with antimicrobial agents against multiresistant gram-positive cocci. |
| AID522902 | Antibacterial activity against vancomycin-intermediate Staphylococcus aureus isolate 1003 after 24 hrs by modified broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Antistaphylococcal activity of ACHN-490 tested alone and in combination with other agents by time-kill assay. |
| AID576863 | Bactericidal activity against 48 hrs peripheral compartment culture samples of Enterococcus faecalis Ef1497 in two-compartment pharmacokinetic/pharmacodynamic model assessed as effect on bacterial count at 800 mg, bid administered as 0.5 hr infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID575270 | Antimicrobial activity against vancomycin-resistant Enterococcus faecium by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Comparative in vitro activity profiles of novel bis-indole antibacterials against gram-positive and gram-negative clinical isolates. |
| AID1374170 | Antibacterial activity against Staphylococcus aureus ATCC 33591 incubated at 37 degC for 20 hrs by agar dilution method | 2018 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4 | Design, synthesis and antibacterial evaluation of honokiol derivatives. |
| AID1687307 | Antimicrobial activity against Escherichia coli JW55031 TolC mutant assessed as reduction in microbial growth incubated for 18 to 20 hrs by broth microdilution method | 2020 | European journal of medicinal chemistry, Jan-15, Volume: 186 | Development of benzimidazole-based derivatives as antimicrobial agents and their synergistic effect with colistin against gram-negative bacteria. |
| AID1852692 | Antibacterial activity against Staphylococcus aureus ATCC 25923 incubated for 24 hrs by twofold serial dilution method | |||
| AID207793 | Compound was evaluated for minimum inhibitory concentration against Staphylococcus aureus 9616 strain | 2002 | Bioorganic & medicinal chemistry letters, Mar-25, Volume: 12, Issue:6 | Synthesis and antibacterial activity of linezolid analogues. |
| AID1578431 | Antimicrobial activity against Listeria monocytogenes ATCC 19111 by broth liquid microdilution method | 2020 | European journal of medicinal chemistry, Jan-01, Volume: 185 | Modifying the lipophilic part of phenylthiazole antibiotics to control their drug-likeness. |
| AID285077 | Antimicrobial activity against viridans group Streptococcus bovis at <= 0.06 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID581041 | Inhibition of mammalian ribosomal activity by coupled transcription/translation assay | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Mode of action of Ranbezolid against staphylococci and structural modeling studies of its interaction with ribosomes. |
| AID524969 | Antibacterial activity against vancomycin-susceptible Enterococcus faecium clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Comparative surveillance study of telavancin activity against recently collected gram-positive clinical isolates from across the United States. |
| AID1421220 | Antibacterial activity against Staphylococcus aureus ATCC 29213 by broth liquid microdilution method | 2018 | European journal of medicinal chemistry, Oct-05, Volume: 158 | Synthesis and antibacterial activity evaluation of novel biaryloxazolidinone analogues containing a hydrazone moiety as promising antibacterial agents. |
| AID285150 | Antimicrobial activity against viridans group Streptococcus oralis at by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID555310 | Antibacterial activity against methicillin-resistant coagulase-negative Staphylococcus epidermidis 225 by broth macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Antistaphylococcal activity of dihydrophthalazine antifolates, a family of novel antibacterial drugs. |
| AID278861 | Inhibition of metabolic activity in HeLa cells assessed as MTT reduction after 48 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Influence on mitochondria and cytotoxicity of different antibiotics administered in high concentrations on primary human osteoblasts and cell lines. |
| AID566572 | Antimicrobial activity against Klebsiella pneumoniae ATCC 10031 by conventional agar-dilution method | 2011 | European journal of medicinal chemistry, Jan, Volume: 46, Issue:1 | Discovery of a novel nitroimidazolyl-oxazolidinone hybrid with potent anti Gram-positive activity: Synthesis and antibacterial evaluation. |
| AID30153 | Volume distribution in Male Sprague-Dawley Rat (10 mg/kg iv) | 2003 | Journal of medicinal chemistry, Jan-16, Volume: 46, Issue:2 | Identification of phenylisoxazolines as novel and viable antibacterial agents active against Gram-positive pathogens. |
| AID499161 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus Smith OC 4172 infected in SKH1 mouse assessed as log change in bacterial colony forming unit per gram of skin tissue at 1.6 mg/kg/day, po (Rvb = 1.6 deltalog CFU) | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vivo activity of ceftobiprole in murine skin infections due to Staphylococcus aureus and Pseudomonas aeruginosa. |
| AID763952 | Antibacterial activity against Moraxella catarrhalis clinical isolate 125 after 18 hrs by NCCLS agar dilution method | 2013 | European journal of medicinal chemistry, Aug, Volume: 66 | Synthesis and antibacterial activities of N-substituted-glycinyl 1H-1,2,3-triazolyl oxazolidinones. |
| AID1895487 | Antibacterial activity against methicillin resistant Staphylococcus aureus incubated for 24 hrs by broth microdilution method | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Synthetic access to thiolane-based therapeutics and biological activity studies. |
| AID671561 | Antibacterial activity against methicillin-resistant Staphylococcus aureus VL-137 | 2012 | Journal of medicinal chemistry, Jan-26, Volume: 55, Issue:2 | Fluorocyclines. 2. Optimization of the C-9 side-chain for antibacterial activity and oral efficacy. |
| AID1519049 | Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay | 2020 | European journal of medicinal chemistry, Jan-01, Volume: 185 | Optimization of biaryloxazolidinone as promising antibacterial agents against antibiotic-susceptible and antibiotic-resistant gram-positive bacteria. |
| AID520233 | Antimicrobial activity against Haemophilus influenzae 54A1100 | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID548526 | Antimicrobial activity against Oxacillin-resistant Staphylococcus aureus by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Activities of dalbavancin against a worldwide collection of 81,673 gram-positive bacterial isolates. |
| AID1852678 | Antibacterial activity against recombinant OM pore producing Acinetobacter baumannii assessed as inhibition of bacterial growth | |||
| AID285122 | Antimicrobial activity against viridans group Streptococcus parasanguis at 0.5 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID131894 | Effective dose required to inhibit Staphylococcus aureus UC9213 in mice subjected to a lethal systemic infection (when administered orally) | 1998 | Bioorganic & medicinal chemistry letters, May-19, Volume: 8, Issue:10 | Synthesis and antibacterial activity of [6,5,5] and [6,6,5] tricyclic fused oxazolidinones. |
| AID304004 | Effect on hematology in Sprague-Dawley rat assessed as decrease in red blood cells at 200 mg/kg/day, po after 14 days | 2007 | Journal of medicinal chemistry, Nov-29, Volume: 50, Issue:24 | Antibacterial oxazolidinones possessing a novel C-5 side chain. (5R)-trans-3-[3-Fluoro-4- (1-oxotetrahydrothiopyran-4-yl)phenyl]-2- oxooxazolidine-5-carboxylic acid amide (PF-00422602), a new lead compound. |
| AID559554 | Antimicrobial activity against compound-intermediate susceptible Coxiella burnetii isolate CP5 obtained from patient with acute Q fever infected in african green monkey Vero cells after 24 hrs by shell vial assay | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Bacteriostatic and bactericidal activities of tigecycline against Coxiella burnetii and comparison with those of six other antibiotics. |
| AID531565 | Antibacterial activity against Enterococcus faecalis obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID285313 | Antimicrobial activity against Pediococcus spp. by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Daptomycin susceptibility of unusual gram-positive bacteria: comparison of results obtained by the Etest and the broth microdilution method. |
| AID1312944 | Antimicrobial activity against vancomycin-resistant Enterococcus faecium ATCC 700221 after 20 hrs by broth microdilution method | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10 | Second-Generation Phenylthiazole Antibiotics with Enhanced Pharmacokinetic Properties. |
| AID1378018 | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv | 2017 | European journal of medicinal chemistry, Sep-29, Volume: 138 | Triazole derivatives and their anti-tubercular activity. |
| AID1390470 | Antibacterial activity against linezolid-resistant Staphylococcus aureus ATCC 13709 SMITH | 2018 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 28, Issue:7 | Design, synthesis and biological evaluation of spiropyrimidinetriones oxazolidinone derivatives as antibacterial agents. |
| AID278856 | Antiproliferative effect against primary human osteoblasts assessed as BrdU incorporation into DNA after 48 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Influence on mitochondria and cytotoxicity of different antibiotics administered in high concentrations on primary human osteoblasts and cell lines. |
| AID523041 | Antimicrobial activity against penicillin-intermediate Streptococcus pneumoniae by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative in vitro antimicrobial activities of torezolid (TR-700), the active moiety of a new oxazolidinone, torezolid phosphate (TR-701), determination of tentative disk diffusion interpretive criteria, and quality control ranges. |
| AID1151774 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus ATCC 29213 in mouse thigh infection model assessed as reduction of log10 CFU per thigh at 40 mg/kg, po | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID523042 | Antimicrobial activity against penicillin-resistant Streptococcus pneumoniae by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative in vitro antimicrobial activities of torezolid (TR-700), the active moiety of a new oxazolidinone, torezolid phosphate (TR-701), determination of tentative disk diffusion interpretive criteria, and quality control ranges. |
| AID245560 | In vitro minimum inhibitory concentration against methicillin-resistant Staphylococcus aureus (ST450, ATCC 15187, ICH 1 and 37) | 2005 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 15, Issue:12 | Synthesis and antibacterial activity of novel (un)substituted benzotriazolyl oxazolidinone derivatives. |
| AID285032 | Antimicrobial activity against Rothia mucilaginosa at 0.25 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID1126485 | Antimicrobial activity against vancomycin-susceptible Staphylococcus aureus ATCC 25923 | 2014 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 24, Issue:8 | Synthesis, antibiotic activity and structure-activity relationship study of some 3-enaminetetramic acids. |
| AID565004 | Antimicrobial activity against methicillin-susceptible coagulase-negative Staphylococcus epidermidis after 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID1126484 | Antimicrobial activity against methicillin-sensitive Staphylococcus aureus ATCC 13709 | 2014 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 24, Issue:8 | Synthesis, antibiotic activity and structure-activity relationship study of some 3-enaminetetramic acids. |
| AID1390479 | Antibacterial activity against Enterococcus faecium ATCC 19434 | 2018 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 28, Issue:7 | Design, synthesis and biological evaluation of spiropyrimidinetriones oxazolidinone derivatives as antibacterial agents. |
| AID1680065 | Antibacterial activity against methicillin-resistant Staphylococcus aureus clinical isolate 1 assessed as reduction in bacterial growth incubated for 16 to 20 hrs by CLSI-based broth microdilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Synthesis and antibacterial bioactivities of cationic deacetyl linezolid amphiphiles. |
| AID561085 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae by CLSI M7-A7 broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | In vitro activity of TR-700, the active ingredient of the antibacterial prodrug TR-701, a novel oxazolidinone antibacterial agent. |
| AID524959 | Antibacterial activity against methicillin-resistant coagulase-negative Staphylococcus hominis clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Comparative surveillance study of telavancin activity against recently collected gram-positive clinical isolates from across the United States. |
| AID1778657 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis ATCC 51559 assessed as bacterial growth inhibition incubated for 24 hrs by CLSI protocol based broth microdilution method | 2021 | European journal of medicinal chemistry, Oct-05, Volume: 221 | Design, synthesis and evaluation of novel 9-arylalkyl-10-methylacridinium derivatives as highly potent FtsZ-targeting antibacterial agents. |
| AID562234 | Antibacterial activity against methicillin-resistant Staphylococcus aureus OC2878 assessed as log reduction in bacterial count at 8 times MIC after 24 hrs by time kill study | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Pharmacokinetic-pharmacodynamic modeling of the in vitro activities of oxazolidinone antimicrobial agents against methicillin-resistant Staphylococcus aureus. |
| AID1151628 | Toxicity in female rat assessed as effect on neutrophil count at 100 mg/kg/day, po bid administered for 4 weeks (Rvb = 22.4%) | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID519092 | Antimicrobial activity against Staphylococcus aureus KM187+198 harboring G2576U mutation in 23S rRNA by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Linezolid and tiamulin cross-resistance in Staphylococcus aureus mediated by point mutations in the peptidyl transferase center. |
| AID285063 | Antimicrobial activity against beta hemolytic Streptococci group F at 1 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID326529 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis UCN41 challenged with 10 times ID90 bacterial size inoculum in Wistar rat assessed as infection at single administration of 600 mg, po | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Single-dose oral amoxicillin or linezolid for prophylaxis of experimental endocarditis due to vancomycin-susceptible and vancomycin-resistant Enterococcus faecalis. |
| AID396031 | Antibacterial activity against drug-resistant AcrAB-TolC efflux pump deficient Enterobacter cloacae EcdeltaacrA isolate expressing pACYC184 plasmid by Etest | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Cloning, nucleotide sequencing, and analysis of the AcrAB-TolC efflux pump of Enterobacter cloacae and determination of its involvement in antibiotic resistance in a clinical isolate. |
| AID244816 | Minimum inhibitory concentration Moraxella catarrhalis | 2005 | Journal of medicinal chemistry, Jul-28, Volume: 48, Issue:15 | Conformational constraint in oxazolidinone antibacterials. Synthesis and structure-activity studies of (azabicyclo[3.1.0]hexylphenyl)oxazolidinones. |
| AID244864 | Minimum inhibitory concentration against Escherichia coli UC6674 | 2005 | Journal of medicinal chemistry, Jul-28, Volume: 48, Issue:15 | Conformational constraint in oxazolidinone antibacterials. Synthesis and structure-activity studies of (azabicyclo[3.1.0]hexylphenyl)oxazolidinones. |
| AID1879691 | Antimycobacterial activity against extensively drug resistant Mycobacterium tuberculosis H37Rv assessed as inhibition of bacterial growth measured after 2 weeks by microbroth dilution method | 2022 | European journal of medicinal chemistry, Mar-15, Volume: 232 | Synthesis and biological evaluation of orally active prodrugs and analogs of para-aminosalicylic acid (PAS). |
| AID1117384 | Antimicrobial activity against Micrococcus luteus ATCC 10240 assessed as inhibition zone at 37 degC for 24 hrs by agar diffusion method | 2010 | MedChemComm, Aug-01, Volume: 1, Issue:2 | Syntheses and biological evaluation of new cephalosporin-oxazolidinone conjugates. |
| AID353062 | Antibacterial activity against vancomycin-resistant Enterococcus 5 after 18 to 20 hrs by agar dilution method | 2009 | Bioorganic & medicinal chemistry letters, May-01, Volume: 19, Issue:9 | Synthesis and antibacterial activities of novel oxazolidinones having spiro[2,4]heptane moieties. |
| AID576405 | Mean residence time in two-compartment pharmacokinetic/pharmacodynamic model at 200 mg, bid administered as 0.5 hrs infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID1304828 | Antibiofilm activity against methicillin-resistant Staphylococcus aureus BAA-1707 assessed as biofilm eradication incubated for 24 hrs by CBD assay | 2016 | Journal of medicinal chemistry, 04-28, Volume: 59, Issue:8 | Structure-Activity Relationships of a Diverse Class of Halogenated Phenazines That Targets Persistent, Antibiotic-Tolerant Bacterial Biofilms and Mycobacterium tuberculosis. |
| AID383558 | Antibacterial activity against Staphylococcus epidermidis ATCC 155 by broth microdilution technique | 2008 | European journal of medicinal chemistry, Apr, Volume: 43, Issue:4 | Synthesis and in vitro antibacterial activities of novel oxazolidinones. |
| AID558517 | Antimicrobial activity against vancomycin-resistant Staphylococcus aureus 510 measured on day 25 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID1327097 | Antibacterial activity against Pseudomonas aeruginosa NCIM 2036 measured after 8 hrs by spectrophotometric method | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Design, synthesis and biological evaluation of novel azaspiro analogs of linezolid as antibacterial and antitubercular agents. |
| AID1778124 | Antitubercular activity against linezolid resistant Mycobacterium tuberculosis assessed as inhibition of bacterial growth incubated for 7 days by MABA | |||
| AID261063 | Antibacterial activity against Enterococcus faecalis MGH-2 EF1-1 | 2006 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 16, Issue:5 | Conformational constraint in oxazolidinone antibacterials. Part 2: Synthesis and structure-activity studies of oxa-, aza-, and thiabicyclo[3.1.0]hexylphenyl oxazolidinones. |
| AID541519 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID285135 | Antimicrobial activity against viridans group Streptococcus sanguinis at 2 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID565011 | Bactericidal activity against methicillin-susceptible coagulase-negative Staphylococcus haemolyticus after 24 hrs by plate counting method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID583407 | Antimicrobial activity against vancomycin-resistant Staphylococcus aureus isolate PA assessed as bacterial count at 4 times MIC after 24 hrs by colony counting method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | In vitro activity of the new multivalent glycopeptide-cephalosporin antibiotic TD-1792 against vancomycin-nonsusceptible Staphylococcus isolates. |
| AID1553387 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus ATCC 43300 measured after 16 hrs by broth microdilution method | 2019 | Bioorganic & medicinal chemistry letters, 09-15, Volume: 29, Issue:18 | Incorporation of a chiral gem-disubstituted nitrogen heterocycle yields an oxazolidinone antibiotic with reduced mitochondrial toxicity. |
| AID1504621 | Antibacterial activity against Enterococcus faecalis ATCC 29212 by microbroth dilution method | 2017 | ACS medicinal chemistry letters, Nov-09, Volume: 8, Issue:11 | Design, Synthesis, and Antibacterial Evaluation of Oxazolidinones with Fused Heterocyclic C-Ring Substructure. |
| AID533401 | Antimicrobial activity against Clostridium subterminale by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activities of doripenem, a new broad-spectrum carbapenem, against recently collected clinical anaerobic isolates, with emphasis on the Bacteroides fragilis group. |
| AID573113 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID1904082 | Antibacterial activity against Pseudomonas aeruginosa HER 1018 | 2022 | European journal of medicinal chemistry, Apr-05, Volume: 233 | Alternative approaches utilizing click chemistry to develop next-generation analogs of solithromycin. |
| AID558730 | Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus 1287 measured on day 50 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID576135 | Antibacterial activity against 10'4 to 10'5 CFU Enterococcus faecium after 18 hrs by CLSI 2-fold agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | In vitro and in vivo activities of LCB01-0371, a new oxazolidinone. |
| AID1079944 | Benign tumor, proven histopathologically. Value is number of references indexed. [column 'T.BEN' in source] | |||
| AID571931 | Antimicrobial activity against Escherichia coli K-12 3-AG300 harboring AcrB-615-628MexB-S623N mutant gene | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Site-directed mutagenesis reveals amino acid residues in the Escherichia coli RND efflux pump AcrB that confer macrolide resistance. |
| AID560511 | Antimicrobial activity against SCCmec type III vancomycin-intermediate Staphylococcus aureus isolate b5k3578 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID572000 | Antibacterial activity against Streptococcus intermedius by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID285375 | Bactericidal activity against methicillin-resistant Staphylococcus aureus ATCC 43300 assessed as reduction of CFU using in vitro PK/PD model with human dosage regimen 600 mg every 12 hrs after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Pharmacokinetic/pharmacodynamic factors influencing emergence of resistance to linezolid in an in vitro model. |
| AID548474 | Antibacterial activity against vancomycin-susceptible Staphylococcus aureus Mu50omega expressing vraSm mutant gene after 48 hrs by Etest | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Contribution of vraSR and graSR point mutations to vancomycin resistance in vancomycin-intermediate Staphylococcus aureus. |
| AID206609 | In vitro antibacterial activity against methicillin-resistant Staphylococcus aureus 241 (MRSA) | 2003 | Bioorganic & medicinal chemistry letters, Nov-17, Volume: 13, Issue:22 | Synthesis and in vitro activity of novel isoxazolyl tetrahydropyridinyl oxazolidinone antibacterial agents. |
| AID311479 | Antimicrobial activity against penicillin-sensitive Streptococcus pneumoniae ATCC 49619 after 14 to 16 hrs by serial microbroth dilution method | 2007 | Journal of natural products, Sep, Volume: 70, Issue:9 | Lipoxazolidinones A, B, and C: antibacterial 4-oxazolidinones from a marine actinomycete isolated from a Guam marine sediment. |
| AID531559 | Antibacterial activity against coagulase-negative Staphylococcus saprophyticus obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID353063 | Antibacterial activity against vancomycin-resistant Enterococcus 6 after 18 to 20 hrs by agar dilution method | 2009 | Bioorganic & medicinal chemistry letters, May-01, Volume: 19, Issue:9 | Synthesis and antibacterial activities of novel oxazolidinones having spiro[2,4]heptane moieties. |
| AID373317 | Antibacterial activity against Staphylococcus epidermidis ATCC 12228 after 18 hrs by NCCLS M7-A4 method | 2009 | European journal of medicinal chemistry, Mar, Volume: 44, Issue:3 | Synthesis, antibacterial and anticonvulsant evaluations of some cyclic enaminones. |
| AID574950 | Antimicrobial activity against Streptococcus pneumoniae serotype 35B by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID428277 | Antituberculosis activity against linezolid-resistant Mycobacterium tuberculosis by bactec 460 TB method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro-selected linezolid-resistant Mycobacterium tuberculosis mutants. |
| AID523033 | Antimicrobial activity against Enterococcus by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative in vitro antimicrobial activities of torezolid (TR-700), the active moiety of a new oxazolidinone, torezolid phosphate (TR-701), determination of tentative disk diffusion interpretive criteria, and quality control ranges. |
| AID1151729 | Antibacterial activity against Streptococcus mitis | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID1151775 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus ATCC 29213 in mouse thigh infection model assessed as reduction of log10 CFU per thigh at 80 mg/kg, po | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID1778102 | Antibacterial activity against Enterococcus faecium ATCC 49624 assessed as bacterial growth inhibition after 18 hrs by broth microdilution method | |||
| AID555295 | Antibacterial activity against Tmp-resistant Staphylococcus aureus by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Antistaphylococcal activity of dihydrophthalazine antifolates, a family of novel antibacterial drugs. |
| AID1117382 | Antimicrobial activity against vancomycin-resistant Enterococcus faecalis 1528 assessed as inhibition zone at 37 degC for 24 hrs by agar diffusion method | 2010 | MedChemComm, Aug-01, Volume: 1, Issue:2 | Syntheses and biological evaluation of new cephalosporin-oxazolidinone conjugates. |
| AID1504620 | Antibacterial activity against linezolid-resistant Staphylococcus aureus by microbroth dilution method | 2017 | ACS medicinal chemistry letters, Nov-09, Volume: 8, Issue:11 | Design, Synthesis, and Antibacterial Evaluation of Oxazolidinones with Fused Heterocyclic C-Ring Substructure. |
| AID559556 | Antimicrobial activity against compound-resistant Coxiella burnetii isolate CP6 obtained from patient with acute Q fever infected in african green monkey Vero cells after 24 hrs by shell vial assay | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Bacteriostatic and bactericidal activities of tigecycline against Coxiella burnetii and comparison with those of six other antibiotics. |
| AID645036 | Antibacterial activity against erythromycin-sensitive Streptococcus pyogenes 3 after 16 to 20 hrs by microbroth dilution method | 2012 | European journal of medicinal chemistry, Apr, Volume: 50 | Synthesis and preliminary antibacterial evaluation of Linezolid-like 1,2,4-oxadiazole derivatives. |
| AID576420 | Cmax in healthy human at 600 mg, iv, bid administered as 0.5 hr infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID1852671 | Antibacterial activity against multidrug resistant Pseudomonas aeruginosa BAA 2108 assessed as inhibition of bacterial growth incubated for 24 hrs in MHI medium by twofold serial dilution method | |||
| AID206222 | In vitro antibacterial activity against Staphylococcus epidermis (S.e.1) ATCC 1228. | 1999 | Bioorganic & medicinal chemistry letters, Sep-20, Volume: 9, Issue:18 | Synthesis and in vitro activity of new oxazolidinone antibacterial agents having substituted isoxazoles. |
| AID1412975 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus after 16 hrs by agar dilution method | 2018 | MedChemComm, May-01, Volume: 9, Issue:5 | The semi-synthesis, biological evaluation and docking analysis of the oxime, hydrazine and hydrazide derivatives of platensimycin. |
| AID533022 | Antibacterial activity against vancomycin-susceptible Staphylococcus aureus N315-LR5-P1-3 assessed as inhibition of bacterial growth in brain heart infusion broth medium | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Improved antimicrobial activity of linezolid against vancomycin-intermediate Staphylococcus aureus. |
| AID125114 | In vitro minimum inhibitory concentration (MIC) against Moraxella catarrhalis UC30610 | 2003 | Journal of medicinal chemistry, Jan-16, Volume: 46, Issue:2 | Identification of phenylisoxazolines as novel and viable antibacterial agents active against Gram-positive pathogens. |
| AID285516 | Antibacterial activity against Enterococcus faecalis | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | In vitro and in vivo antibacterial activities of heteroaryl isothiazolones against resistant gram-positive pathogens. |
| AID572272 | Antimicrobial activity against Streptococcus pneumoniae ATCC 6301 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vivo characterization of the peptide deformylase inhibitor LBM415 in murine infection models. |
| AID1308233 | Antibacterial activity against Bacillus cereus ATCC 13061 incubated for 16 to 20 hrs by microdilution method | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10 | Structure-Activity Relationship for the 4(3H)-Quinazolinone Antibacterials. |
| AID319168 | Inhibition of monoamine oxidase A | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7 | Linezolid (ZYVOX), the first member of a completely new class of antibacterial agents for treatment of serious gram-positive infections. |
| AID544820 | Antimicrobial activity against Staphylococcus epidermidis Xen 43 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Effect of electrical current on the activities of antimicrobial agents against Pseudomonas aeruginosa, Staphylococcus aureus, and Staphylococcus epidermidis biofilms. |
| AID565749 | Antimicrobial activity against Enterococcus faecalis expressing VanA gene clinical isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID1428626 | Antibacterial activity against methicillin-resistant Staphylococcus aureus USA300 by broth microdilution method | 2017 | European journal of medicinal chemistry, Feb-15, Volume: 127 | Diaryltriazenes as antibacterial agents against methicillin resistant Staphylococcus aureus (MRSA) and Mycobacterium smegmatis. |
| AID424760 | Antibacterial activity against macrolide, methicillin-resistant Staphylococcus aureus CL5705 after 20 hrs by twofold serial broth dilution method | 2009 | Journal of natural products, May-22, Volume: 72, Issue:5 | Thiazomycins, thiazolyl peptide antibiotics from Amycolatopsis fastidiosa. |
| AID1414206 | Bactericidal activity against methicillin-resistant Staphylococcus aureus ATCC 43300 assessed as reduction in viable bacterial count at 8 ug/ml after 24 hrs by time-kill assay | 2018 | European journal of medicinal chemistry, Nov-05, Volume: 159 | Design, synthesis and structure-based optimization of novel isoxazole-containing benzamide derivatives as FtsZ modulators. |
| AID206607 | In vitro antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) | 2003 | Bioorganic & medicinal chemistry letters, Jul-07, Volume: 13, Issue:13 | Synthesis and in vitro activity of new methylenepiperidinyl and methylenepyrrolidinyl oxazolidinone antibacterial agents. |
| AID263968 | Efficacy against po dosed mouse infected with Staphylococcus aureus ATCC 29213 | 2006 | Bioorganic & medicinal chemistry letters, May-01, Volume: 16, Issue:9 | Synthesis and antibacterial activity of novel oxazolidinones bearing N-hydroxyacetamidine substituent. |
| AID520228 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus BK 11118 | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID285142 | Antimicrobial activity against beta hemolytic Streptococcus group F by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID524960 | Antibacterial activity against methicillin-resistant coagulase-negative Staphylococcus saprophyticus clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Comparative surveillance study of telavancin activity against recently collected gram-positive clinical isolates from across the United States. |
| AID523026 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative in vitro antimicrobial activities of torezolid (TR-700), the active moiety of a new oxazolidinone, torezolid phosphate (TR-701), determination of tentative disk diffusion interpretive criteria, and quality control ranges. |
| AID523045 | Antimicrobial activity against Listeria monocytogenes by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative in vitro antimicrobial activities of torezolid (TR-700), the active moiety of a new oxazolidinone, torezolid phosphate (TR-701), determination of tentative disk diffusion interpretive criteria, and quality control ranges. |
| AID520015 | Antimicrobial activity against Staphylococcus hominis A7828 | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID1578410 | Antimicrobial activity against methicillin-sensitive Staphylococcus aureus ATCC 6538 by broth liquid microdilution method | 2020 | European journal of medicinal chemistry, Jan-01, Volume: 185 | Modifying the lipophilic part of phenylthiazole antibiotics to control their drug-likeness. |
| AID268865 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis NCTC 12201 | 2006 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 16, Issue:16 | Synthesis of novel tricyclic oxazolidinones by a tandem SN2 and SNAr reaction: SAR studies on conformationally constrained analogues of Linezolid. |
| AID528737 | Antibacterial activity against methicillin resistant Staphylococcus epidermidis clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID552857 | Antibacterial activity against Enterococcus faecium infected in po dosed in vivo acute model administered bid for 1 day | 2011 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1 | The discovery and structure-activity relationships leading to CE-156811, a difluorophenyl cyclopropyl fluoroether: a novel potent antibacterial analog derived from hygromycin A. |
| AID726197 | Antibacterial activity against vancomycin-resistant Enterococcus faecium C803 by agar dilution method | 2013 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 23, Issue:5 | Synthesis and antibacterial activities of new piperidine substituted (5R)-[1,2,3]triazolylmethyl and (5R)-[(4-F-[1,2,3]triazolyl)methyl] oxazolidinones. |
| AID1710582 | Antibacterial activity against methicillin-resistant Staphylococcus aureus NRS483 assessed as inhibition of visible bacterial growth incubated for 18 to 20 hrs by CLSI method | 2020 | RSC medicinal chemistry, Jan-01, Volume: 11, Issue:1 | Potent trifluoromethoxy, trifluoromethylsulfonyl, trifluoromethylthio and pentafluorosulfanyl containing (1,3,4-oxadiazol-2-yl)benzamides against drug-resistant Gram-positive bacteria. |
| AID1609262 | Bactericidal activity against vancomycin-resistant Enterococcus faecium ATCC 700221 incubated for 18 to 20 hrs followed by replating on tryptic soy agar plate and further incubated for 18 to 24 hrs by CLSI-based broth microdilution assay | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Phenylthiazoles with nitrogenous side chain: An approach to overcome molecular obesity. |
| AID575264 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Comparative in vitro activity profiles of novel bis-indole antibacterials against gram-positive and gram-negative clinical isolates. |
| AID541042 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 infected in Albino guiena pig assessed as no. of culture-negative cage fluid samples at 75 mg/kg measured on day 10 postinfection | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Linezolid alone or combined with rifampin against methicillin-resistant Staphylococcus aureus in experimental foreign-body infection. |
| AID285507 | Antibacterial activity against methicillin-resistant Staphylococcus aureus after 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | In vitro and in vivo antibacterial activities of heteroaryl isothiazolones against resistant gram-positive pathogens. |
| AID533966 | Bacteriostatic activity against Legionella pneumophila ATCC 33153 infected in THP1 cells after 48hrs | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Cellular pharmacodynamics of the novel biaryloxazolidinone radezolid: studies with infected phagocytic and nonphagocytic cells, using Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Legionella pneumophila. |
| AID244933 | Minimal inhibitory concentration against Staphylococcus aureus ATCC 25923 | 2004 | Bioorganic & medicinal chemistry letters, Sep-20, Volume: 14, Issue:18 | Synthesis and antibacterial activity of some aryloxy/thioaryloxy oxazolidinone derivatives. |
| AID572007 | Antibacterial activity against Bacteroides splanchnicus by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID285518 | Antibacterial activity against Streptococcus pyogenes | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | In vitro and in vivo antibacterial activities of heteroaryl isothiazolones against resistant gram-positive pathogens. |
| AID29723 | Tmax value in Male Sprague-Dawley Rat at dose 25 (mg/kg po) [tmax (h)] | 2003 | Journal of medicinal chemistry, Jan-16, Volume: 46, Issue:2 | Identification of phenylisoxazolines as novel and viable antibacterial agents active against Gram-positive pathogens. |
| AID729217 | Antibacterial activity against linezolid-resistant Staphylococcus epidermidis after 16 hrs by NCCLS agar dilution method | 2013 | Journal of medicinal chemistry, Mar-28, Volume: 56, Issue:6 | Solubility-driven optimization of (pyridin-3-yl) benzoxazinyl-oxazolidinones leading to a promising antibacterial agent. |
| AID1167988 | Antibacterial activity against vancomycin-resistant Enterococcus ATCC 29212 after overnight incubation by two-fold serial dilution method | 2014 | Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21 | Synthesis and biological evaluation of novel peptide BF2 as an antibacterial agent against clinical isolates of vancomycin-resistant enterococci. |
| AID326509 | Tmax in Enterococcus faecalis infected Wistar rat at single administration of 600 mg, po | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Single-dose oral amoxicillin or linezolid for prophylaxis of experimental endocarditis due to vancomycin-susceptible and vancomycin-resistant Enterococcus faecalis. |
| AID541784 | Antimicrobial activity against Streptococcus pyogenes clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID1861537 | Clearance in Wistar rat at 15 mg/kg, iv | 2022 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 71 | WCK 4034: A promising oxazolidinone for treating gram positive infections. |
| AID558702 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus 547 measured on day 35 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID522822 | Antibacterial activity against vancomycin-hetero-intermediate Staphylococcus aureus after 24 hrs by modified broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Antistaphylococcal activity of ACHN-490 tested alone and in combination with other agents by time-kill assay. |
| AID1421230 | Antibacterial activity against methicillin-resistant Staphylococcus aureus clinical isolates by broth liquid microdilution method | 2018 | European journal of medicinal chemistry, Oct-05, Volume: 158 | Synthesis and antibacterial activity evaluation of novel biaryloxazolidinone analogues containing a hydrazone moiety as promising antibacterial agents. |
| AID575268 | Antimicrobial activity against vancomycin-resistant Enterococcus faecalis by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Comparative in vitro activity profiles of novel bis-indole antibacterials against gram-positive and gram-negative clinical isolates. |
| AID270147 | Antibacterial activity against gram positive vancomycin-susceptible Enterococcus faecalis ATCC 29212 | 2006 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 16, Issue:17 | Antibacterial activity of pyrrolopyridine-substituted oxazolidinones: synthesis and in vitro SAR of various C-5 acetamide replacements. |
| AID1721058 | Toxicity in Mycobacterium tuberculosis H37Rv infected Balb/c mouse assessed as change in body weight at 100 mg/kg/day, po administered via gavage 5 times per week for 3 weeks starting from 10 days post-infection (Rvb = 21.29 +/- 0.84 g) | 2020 | Journal of medicinal chemistry, 09-10, Volume: 63, Issue:17 | Discovery of a Conformationally Constrained Oxazolidinone with Improved Safety and Efficacy Profiles for the Treatment of Multidrug-Resistant Tuberculosis. |
| AID1770345 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC43300 assessed as inhibition of bacterial growth measured after 20 hrs by two-fold microdilution assay | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Modification of 5-methylphenanthridium from benzothiazoles to indoles as potent FtsZ inhibitors: Broadening the antibacterial spectrum toward vancomycin-resistant enterococci. |
| AID534250 | Bacteriostatic activity against linezolid-susceptible Staphylococcus aureus SA238 infected in THP1 cells at pH 7.4 after 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Cellular pharmacodynamics of the novel biaryloxazolidinone radezolid: studies with infected phagocytic and nonphagocytic cells, using Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Legionella pneumophila. |
| AID559772 | Antimicrobial activity against heterogeneous vancomycin-intermediate Staphylococcus aureus by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID511393 | Antibacterial activity against Levofloxacin resistant Streptococcus pneumoniae by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Comparative in vitro activities of nemonoxacin (TG-873870), a novel nonfluorinated quinolone, and other quinolones against clinical isolates. |
| AID548257 | Antibacterial activity against vancomycin-susceptible Staphylococcus aureus Mu50omega expressing vraSm, graRm mutant gene after 24 hrs by Etest | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Contribution of vraSR and graSR point mutations to vancomycin resistance in vancomycin-intermediate Staphylococcus aureus. |
| AID572019 | Antibacterial activity against Prevotella loescheii by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID523035 | Antimicrobial activity against vancomycin-susceptible Enterococcus faecalis by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative in vitro antimicrobial activities of torezolid (TR-700), the active moiety of a new oxazolidinone, torezolid phosphate (TR-701), determination of tentative disk diffusion interpretive criteria, and quality control ranges. |
| AID528732 | Antibacterial activity against methicillin resistant coagulase-negative Staphylococcus saprophyticus clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID1197124 | Antibacterial activity against Streptococcus pyogenes ATCC 49399 after 16 to 20 hrs by broth microdilution method | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3 | Structure-activity relationship for the oxadiazole class of antibiotics. |
| AID1873947 | Antibacterial activity against Staphylococcus aureus ATCC 29213 at pH 8.6 incubated for 16 to 20 hrs in presence of 25% foetal bovine serum by broth microdilution method | 2022 | European journal of medicinal chemistry, Aug-05, Volume: 238 | Design, synthesis and activity against drug-resistant bacteria evaluation of C-20, C-23 modified 5-O-mycaminosyltylonolide derivatives. |
| AID545602 | Bacteriostatic activity against stationary-phase methicillin-resistant Staphylococcus aureus ATCC 33591 grown on nutrient-depleted CAMHB medium at 8 ug/ml after 24 hrs by time kill analysis | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Oritavancin kills stationary-phase and biofilm Staphylococcus aureus cells in vitro. |
| AID85956 | Antibacterial activity against Haemophilus influenzae UC30063 (Haemophilus influenzae) | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | Synthesis and biological evaluation of benzazepine oxazolidinone antibacterials. |
| AID278572 | Antimicrobial activity against Streptococcus pyogenes ATCC 19615 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | In vitro activities of the lipopeptides palmitoyl (Pal)-Lys-Lys-NH(2) and Pal-Lys-Lys alone and in combination with antimicrobial agents against multiresistant gram-positive cocci. |
| AID245045 | Minimal inhibitory concentration against Enterococcus faecalis (VRE) ATCC 346-VRE | 2004 | Bioorganic & medicinal chemistry letters, Sep-20, Volume: 14, Issue:18 | Synthesis and antibacterial activity of some aryloxy/thioaryloxy oxazolidinone derivatives. |
| AID535256 | Antimicrobial activity against vancomycin resistant Staphylococcus aureus VRS-4 expressing SCCmec type 4 element by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | In vitro activity of ceftaroline against community-associated methicillin-resistant, vancomycin-intermediate, vancomycin-resistant, and daptomycin-nonsusceptible Staphylococcus aureus isolates. |
| AID576125 | Antibacterial activity against 1 x 10'8 CFU methicillin-resistant Staphylococcus aureus p125 infected in ICR mouse systemic infection model assessed as mouse protection administered orally twice after 1 and 4 hrs post infection measured after 48 hrs | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | In vitro and in vivo activities of LCB01-0371, a new oxazolidinone. |
| AID1873914 | Antibacterial activity against Pseudomonas aeruginosa LTP-3 incubated for 16 to 20 hrs by broth microdilution method | 2022 | European journal of medicinal chemistry, Aug-05, Volume: 238 | Design, synthesis and activity against drug-resistant bacteria evaluation of C-20, C-23 modified 5-O-mycaminosyltylonolide derivatives. |
| AID577119 | Cmax in two-compartment pharmacokinetic/pharmacodynamic model at 600 mg, bid administered as 0.5 hr infusion over 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID717212 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus CCARM 3089 incubated for 24 hrs by microtiter broth dilution method | 2012 | Journal of natural products, Dec-28, Volume: 75, Issue:12 | Antibacterial butenolides from the Korean tunicate Pseudodistoma antinboja. |
| AID1304853 | Antibacterial activity against methicillin-resistant Staphylococcus aureus clinical isolate 2 incubated for 16 hrs by broth microdilution method | 2016 | Journal of medicinal chemistry, 04-28, Volume: 59, Issue:8 | Structure-Activity Relationships of a Diverse Class of Halogenated Phenazines That Targets Persistent, Antibiotic-Tolerant Bacterial Biofilms and Mycobacterium tuberculosis. |
| AID83804 | In vitro minimum inhibitory concentration (MIC) against Haemophilus influenzae UC30063 | 2003 | Journal of medicinal chemistry, Jan-16, Volume: 46, Issue:2 | Identification of phenylisoxazolines as novel and viable antibacterial agents active against Gram-positive pathogens. |
| AID311478 | Antimicrobial activity against Staphylococcus epidermidis ATCC 700582 after 14 to 16 hrs by serial microbroth dilution method | 2007 | Journal of natural products, Sep, Volume: 70, Issue:9 | Lipoxazolidinones A, B, and C: antibacterial 4-oxazolidinones from a marine actinomycete isolated from a Guam marine sediment. |
| AID125242 | The compound was evaluated for its anti-bacterial activity against Moraxella catarrhalis UC 30610 | 1998 | Journal of medicinal chemistry, Dec-17, Volume: 41, Issue:26 | Nitrogen-carbon-linked (azolylphenyl)oxazolidinones with potent antibacterial activity against the fastidious gram-negative organisms Haemophilus influenzae and Moraxella catarrhalis. |
| AID530121 | Antimicrobial activity against hospital acquired methicillin-resistant Staphylococcus aureus 152 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Pharmacodynamic characterization of ceftobiprole in experimental pneumonia caused by phenotypically diverse Staphylococcus aureus strains. |
| AID730746 | Antibacterial activity against methicillin-resistant Staphylococcus aureus 2111-10-USA300 harboring cfr gene assessed as growth inhibition | 2013 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 23, Issue:6 | Novel 3-O-carbamoyl erythromycin A derivatives (carbamolides) with activity against resistant staphylococcal and streptococcal isolates. |
| AID524692 | Antibacterial activity against Listeria monocytogenes clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro antibacterial activity of CE-156811, a novel analog derived from hygromycin A. |
| AID1473740 | Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and GSH measured after 10 mins by membrane vesicle transport assay | 2013 | Toxicological sciences : an official journal of the Society of Toxicology, Nov, Volume: 136, Issue:1 | A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. |
| AID571833 | Antibacterial activity against Ruminococcus flavefaciens by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID1514450 | Antitubercular activity against streptomycin-resistant Mycobacterium tuberculosis after 7 days by resazurin dye based colorimetric assay | 2019 | Bioorganic & medicinal chemistry letters, 01-01, Volume: 29, Issue:1 | Synthesis, antituberculosis studies and biological evaluation of new quinoline derivatives carrying 1,2,4-oxadiazole moiety. |
| AID560522 | Antimicrobial activity against SCCmec type III vancomycin-intermediate Staphylococcus aureus isolate gz07030 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID571811 | Antibacterial activity against Clostridium sporogenes by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID1168003 | Antibacterial activity against vancomycin-resistant Enterococcus faecium clinical isolate 7/27 after overnight incubation by two-fold serial dilution method | 2014 | Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21 | Synthesis and biological evaluation of novel peptide BF2 as an antibacterial agent against clinical isolates of vancomycin-resistant enterococci. |
| AID565016 | Antimicrobial activity against methicillin-susceptible coagulase-negative Staphylococcus sciuri after 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID533969 | Antimicrobial activity against linezolid-susceptible Staphylococcus aureus NRS384 infected in THP1 cells assessed as log reduction in bacterial count after 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Cellular pharmacodynamics of the novel biaryloxazolidinone radezolid: studies with infected phagocytic and nonphagocytic cells, using Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Legionella pneumophila. |
| AID640890 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus by agar microdilution method | 2012 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 22, Issue:2 | Design, synthesis, and structure-activity relationship studies of conformationally restricted mutilin 14-carbamates. |
| AID561094 | Antibacterial activity against Clostridium perfringens by CLSI M11-A7 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | In vitro activity of TR-700, the active ingredient of the antibacterial prodrug TR-701, a novel oxazolidinone antibacterial agent. |
| AID523034 | Antimicrobial activity against vancomycin-resistant Enterococcus faecalis by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative in vitro antimicrobial activities of torezolid (TR-700), the active moiety of a new oxazolidinone, torezolid phosphate (TR-701), determination of tentative disk diffusion interpretive criteria, and quality control ranges. |
| AID535032 | Antimicrobial activity against vancomycin intermediate Staphylococcus aureus NRS-76 expressing SCCmec type 2 element by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | In vitro activity of ceftaroline against community-associated methicillin-resistant, vancomycin-intermediate, vancomycin-resistant, and daptomycin-nonsusceptible Staphylococcus aureus isolates. |
| AID531568 | Antibacterial activity against Streptococcus pyogenes obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID1327119 | Antitubercular activity against dormant stage Mycobacterium tuberculosis H37Ra at 3 ug/ml measured after 12 days by XTT assay | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Design, synthesis and biological evaluation of novel azaspiro analogs of linezolid as antibacterial and antitubercular agents. |
| AID285328 | Antimicrobial activity against vancomycin-resistant Enterococcus faecalis ATCC 51299 | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | In vitro activity of aurein 1.2 alone and in combination with antibiotics against gram-positive nosocomial cocci. |
| AID559282 | Antimicrobial activity against Enterococcus faecalis JH2-2 harboring nucleotides at position 2576 in rrlA 2576T, rrlB 2576G, rrlC 2576G/T and rrlD 2576T after 6, 8 passages under Linezolid selective pressure by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Influence of recombination on development of mutational resistance to linezolid in Enterococcus faecalis JH2-2. |
| AID542713 | fT>MIC in Bacillus anthracis infected in vitro hollow fiber PK/PD model at simulated dose of 600 mg /day | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID285152 | Antimicrobial activity against viridans group Streptococcus salivarius by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID574080 | Ratio of fAUC (24 hrs) for Methicillin-susceptible Staphylococcus aureus ATCC 13709 infected iv dosed mouse to MIC for Methicillin-susceptible Staphylococcus aureus ATCC 1370 | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | In vivo activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. |
| AID283628 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus Ho 4536-0368 with heterozygous 23S rRNA G2576U mutation | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | In vitro activity of the oxazolidinone RWJ-416457 against linezolid-resistant and -susceptible staphylococci and enterococci. |
| AID561078 | Antibacterial activity against methicillin-resistant Staphylococcus epidermidis by CLSI M7-A7 broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | In vitro activity of TR-700, the active ingredient of the antibacterial prodrug TR-701, a novel oxazolidinone antibacterial agent. |
| AID1117369 | Antimicrobial activity against Bacillus subtilis ATCC 6633 assessed as inhibition zone at 37 degC for 24 hrs by agar diffusion method | 2010 | MedChemComm, Aug-01, Volume: 1, Issue:2 | Syntheses and biological evaluation of new cephalosporin-oxazolidinone conjugates. |
| AID1609269 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis ATCC 51299 after 18 to 20 hrs by CLSI-based broth microdilution assay | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Phenylthiazoles with nitrogenous side chain: An approach to overcome molecular obesity. |
| AID533638 | Antimicrobial activity against Propionibacterium sp. assessed as resistant isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activities of doripenem, a new broad-spectrum carbapenem, against recently collected clinical anaerobic isolates, with emphasis on the Bacteroides fragilis group. |
| AID1703716 | Antibacterial activity against methicillin-resistant Staphylococcus aureus USA700 NRS386 assessed as inhibition of bacterial growth measured after 18 to 20 hrs by CLSI protocol based broth microdilution method | 2020 | European journal of medicinal chemistry, Sep-15, Volume: 202 | Evaluation of N-phenyl-2-aminothiazoles for treatment of multi-drug resistant and intracellular Staphylococcus aureus infections. |
| AID575267 | Antimicrobial activity against vancomycin-susceptible Enterococcus faecalis by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Comparative in vitro activity profiles of novel bis-indole antibacterials against gram-positive and gram-negative clinical isolates. |
| AID573149 | Antibacterial activity against vancomycin-susceptible Enterococcus faecalis by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID207421 | In vitro antibacterial activity against Staphylococcus aureus ATCC 29213 (S. a. 035) | 2002 | Journal of medicinal chemistry, Aug-29, Volume: 45, Issue:18 | Synthesis of conformationally constrained analogues of linezolid: structure-activity relationship (SAR) studies on selected novel tricyclic oxazolidinones. |
| AID534256 | Antimicrobial activity against linezolid-resistant Staphylococcus aureus SA238L infected in THP1 cells assessed as log reduction in bacterial count after 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Cellular pharmacodynamics of the novel biaryloxazolidinone radezolid: studies with infected phagocytic and nonphagocytic cells, using Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Legionella pneumophila. |
| AID562177 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus 525 after 50 passages by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID319156 | Toxicity in dog at 40 mg/kg, po for 30 days | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7 | Linezolid (ZYVOX), the first member of a completely new class of antibacterial agents for treatment of serious gram-positive infections. |
| AID571992 | Antibacterial activity against Anaerococcus prevotii by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID1688277 | In vivo antibacterial activity against methicillin resistant Staphylococcus aureus clinical isolate 15-1 infected in kunming mouse assessed as animal survival rate at 9 mg/kg, po administered 6 hrs prior to bacterial infection and at 0 and 6 hrs post infe | 2020 | European journal of medicinal chemistry, Feb-15, Volume: 188 | N-thiadiazole-4-hydroxy-2-quinolone-3-carboxamides bearing heteroaromatic rings as novel antibacterial agents: Design, synthesis, biological evaluation and target identification. |
| AID562162 | Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus 1287 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID1832943 | Antibacterial activity against Vanomycin-sensitive Enterococcus faecalis NCTC 775 assessed as reduction in bacterial growth incubated for 20 hrs by microplate reader method | 2021 | Bioorganic & medicinal chemistry, 11-01, Volume: 49 | Synthesis, microbiological evaluation and structure activity relationship analysis of linezolid analogues with different C5-acylamino substituents. |
| AID561246 | Antibacterial activity against methicillin-resistant Staphylococcus epidermidis assessed as susceptible isolates by CLSI M100-S17 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | AFN-1252, a FabI inhibitor, demonstrates a Staphylococcus-specific spectrum of activity. |
| AID562617 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus assessed as susceptible isolates by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | In vitro activities of three new dihydrofolate reductase inhibitors against clinical isolates of gram-positive bacteria. |
| AID284899 | Antimicrobial activity against heterogeneous glycopeptide-intermediate Staphylococcus aureus by broth microdilution technique after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Antimicrobial activities of ceragenins against clinical isolates of resistant Staphylococcus aureus. |
| AID1350028 | Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate 11 incubated overnight by agar dilution method | 2018 | Journal of natural products, 02-23, Volume: 81, Issue:2 | Biomimetic Stereoselective Sulfa-Michael Addition Leads to Platensimycin and Platencin Sulfur Analogues against Methicillin-Resistant Staphylococcus aureus. |
| AID671565 | Antibacterial activity against Moraxella catarrhalis | 2012 | Journal of medicinal chemistry, Jan-26, Volume: 55, Issue:2 | Fluorocyclines. 2. Optimization of the C-9 side-chain for antibacterial activity and oral efficacy. |
| AID127506 | Antibacterial activity against Moraxella catarrhalis (MC1002) | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | Novel oxazolidinone-quinolone hybrid antimicrobials. |
| AID91253 | Compound was evaluated for metabolic stability via In vitro Human 5E6 cell at 25 uM concentration; ND denotes not determined | 2003 | Journal of medicinal chemistry, Jan-16, Volume: 46, Issue:2 | Identification of phenylisoxazolines as novel and viable antibacterial agents active against Gram-positive pathogens. |
| AID1877884 | Antibacterial activity against methicillin-resistant Staphylococcus aureus N315 assessed as bacterial growth inhibition | 2022 | Bioorganic & medicinal chemistry letters, 03-01, Volume: 59 | Novel 2,4-disubstituted quinazoline analogs as antibacterial agents with improved cytotoxicity profile: Modification of the benzenoid part. |
| AID523782 | Antimicrobial activity against linezolid-resistant Staphylococcus aureus by CLSI method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative activities of TR-700 (torezolid) against staphylococcal blood isolates collected in Spain. |
| AID532789 | Antibacterial activity against vancomycin-intermediate Staphylococcus aureus BR1 after 24 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Improved antimicrobial activity of linezolid against vancomycin-intermediate Staphylococcus aureus. |
| AID576878 | Bactericidal activity against 13 hrs peripheral compartment culture samples of Enterococcus faecalis Ef1497 MutM3 in two-compartment pharmacokinetic/pharmacodynamic model assessed as effect on bacterial count at 600 mg, bid administered as 0.5 hr infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID1375999 | Inhibition of Mycobacterium tuberculosis H37Rv cytochrome bc1 oxidase assessed as reduction in ATP level measured up to 24 hrs under anaerobic condition | 2016 | MedChemComm, Nov-01, Volume: 7, Issue:11 | SAR and identification of 2-(quinolin-4-yloxy)acetamides as |
| AID1547715 | Antibacterial activity against Enterococcus faecalis ATCC 29212 by broth microdilution method | 2020 | ACS medicinal chemistry letters, Mar-12, Volume: 11, Issue:3 | Structure-Activity Relationship for the Oxadiazole Class of Antibacterials. |
| AID285349 | Antibacterial activity against community acquired methicillin-resistant Staphylococcus aureus HT20030203 in CCY media | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Effect of antibiotics on Staphylococcus aureus producing Panton-Valentine leukocidin. |
| AID370033 | Antibacterial activity against linezolid-resistant methicillin-resistant Staphylococcus aureus infected in po dosed C3H mouse localized infection model assessed as reduction of number of CFU per gram of thigh administered 2 hrs postinfection thrice daily | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vivo efficacy of a novel oxazolidinone compound in two mouse models of infection. |
| AID523043 | Antimicrobial activity against Streptococcus viridans by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative in vitro antimicrobial activities of torezolid (TR-700), the active moiety of a new oxazolidinone, torezolid phosphate (TR-701), determination of tentative disk diffusion interpretive criteria, and quality control ranges. |
| AID1197125 | Antibacterial activity against Bacillus cereus ATCC 13061 after 16 to 20 hrs by broth microdilution method | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3 | Structure-activity relationship for the oxadiazole class of antibiotics. |
| AID1493811 | Antibacterial activity against Enterobacter cloacae BAA-1154 after 20 hrs by broth microdilution method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Biphenylthiazole antibiotics with an oxadiazole linker: An approach to improve physicochemical properties and oral bioavailability. |
| AID1553369 | Inhibition of protein synthesis in mitochondria (unknown origin) assessed as [35S]methionine incorporation incubated for 15 to 120 mins by paper disk assay | 2019 | Bioorganic & medicinal chemistry letters, 09-15, Volume: 29, Issue:18 | Incorporation of a chiral gem-disubstituted nitrogen heterocycle yields an oxazolidinone antibiotic with reduced mitochondrial toxicity. |
| AID1687317 | Synergistic antibacterial activity against Pseudomonas aeruginosa ATCC 15442 in presence of 0.25 times MIC of colistin incubated for 18 to 20 hrs by broth microdilution method | 2020 | European journal of medicinal chemistry, Jan-15, Volume: 186 | Development of benzimidazole-based derivatives as antimicrobial agents and their synergistic effect with colistin against gram-negative bacteria. |
| AID1311365 | Antibacterial activity against Enterococcus faecalis ATCC 19433 measured after 18 hrs by broth microdilution assay | 2016 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15 | An evolved oxazolidinone with selective potency against Mycobacterium tuberculosis and gram positive bacteria. |
| AID574551 | Decrease in delta toxin levels in Staphylococcus aureus Sanger 252 at subinhibitory concentrations after 24 hrs by RP-HPLC/ESI- MS | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Subinhibitory concentrations of protein synthesis-inhibiting antibiotics promote increased expression of the agr virulence regulator and production of phenol-soluble modulin cytolysins in community-associated methicillin-resistant Staphylococcus aureus. |
| AID533956 | Antimicrobial activity against Staphylococcus epidermidis infected in THP1 cells assessed as log reduction in bacterial count after 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Cellular pharmacodynamics of the novel biaryloxazolidinone radezolid: studies with infected phagocytic and nonphagocytic cells, using Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Legionella pneumophila. |
| AID1151766 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae isolate 0613 in po dosed mouse systemic infection model | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID1689208 | Antibacterial activity against Clostridium difficile BAA1870 assessed as reduction in bacterial growth by CLSI based broth microdilution method | 2020 | European journal of medicinal chemistry, Mar-01, Volume: 189 | Oxadiazolylthiazoles as novel and selective antifungal agents. |
| AID576676 | Bactericidal activity against 1 hr peripheral compartment culture samples of Enterococcus faecalis Ef1497 in two-compartment pharmacokinetic/pharmacodynamic model assessed as effect on bacterial count at 800 mg, bid administered as 0.5 hr infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID1647978 | Antibacterial activity against Staphylococcus aureus ATCC 29213 by resazurin dye based microdilution method | 2020 | Journal of natural products, 02-28, Volume: 83, Issue:2 | The Isolation of Pyrroloformamide Congeners and Characterization of Their Biosynthetic Gene Cluster. |
| AID283623 | Antimicrobial activity against Enterococcus faecium 16 with homozygous 23S rRNA G2576U mutation | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | In vitro activity of the oxazolidinone RWJ-416457 against linezolid-resistant and -susceptible staphylococci and enterococci. |
| AID563324 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis EF NJ1 assessed as log reduction in bacterial count at 12 mg/l after 24 hrs by time kill assay | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | In vivo activity of a novel anti-methicillin-resistant Staphylococcus aureus cephalosporin, ceftaroline, against vancomycin-susceptible and -resistant Enterococcus faecalis strains in a rabbit endocarditis model: a comparative study with linezolid and van |
| AID1409852 | Antibacterial activity against linezolid-resistant Staphylococcus aureus NRS271 infected in BALB/c mouse assessed as reduction of bacterial burden in heart at 0.1 mg, ip bid administered at 12 hrs prior to bacterial infection dosed at 12 intervals for 4.5 | 2018 | ACS medicinal chemistry letters, Mar-08, Volume: 9, Issue:3 | Novel Staphyloxanthin Inhibitors with Improved Potency against Multidrug Resistant |
| AID1501361 | Antibacterial activity against vancomycin-resistant Staphylococcus aureus isolate 4 after 20 hrs by broth microdilution assay | 2017 | European journal of medicinal chemistry, Oct-20, Volume: 139 | Arylthiazole antibiotics targeting intracellular methicillin-resistant Staphylococcus aureus (MRSA) that interfere with bacterial cell wall synthesis. |
| AID303963 | Inhibition of human recombinant MAOA | 2007 | Journal of medicinal chemistry, Nov-29, Volume: 50, Issue:24 | Antibacterial oxazolidinones possessing a novel C-5 side chain. (5R)-trans-3-[3-Fluoro-4- (1-oxotetrahydrothiopyran-4-yl)phenyl]-2- oxooxazolidine-5-carboxylic acid amide (PF-00422602), a new lead compound. |
| AID532788 | Antibacterial activity against vancomycin-intermediate Staphylococcus aureus BR2 after 24 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Improved antimicrobial activity of linezolid against vancomycin-intermediate Staphylococcus aureus. |
| AID1603257 | Antibacterial activity against INH-resistant Mycobacterium tuberculosis after 7 days by microplate alamar blue assay | |||
| AID323830 | Antibacterial activity against methicillin-resistant Staphylococcus aureus Xen1 infected neutropenic CD1 mouse assessed as mortality at 100 mg/kg, po after 4 days | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Rapid bactericidal activity of daptomycin against methicillin-resistant and methicillin-susceptible Staphylococcus aureus peritonitis in mice as measured with bioluminescent bacteria. |
| AID533396 | Antimicrobial activity against Clostridium innocuum assessed as resistant isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activities of doripenem, a new broad-spectrum carbapenem, against recently collected clinical anaerobic isolates, with emphasis on the Bacteroides fragilis group. |
| AID1167994 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis clinical isolate 7846 after overnight incubation by two-fold serial dilution method | 2014 | Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21 | Synthesis and biological evaluation of novel peptide BF2 as an antibacterial agent against clinical isolates of vancomycin-resistant enterococci. |
| AID759691 | Antibacterial activity against methicillin-resistant Staphylococcus aureus F511 assessed as growth inhibition after 18 to 24 hrs by broth microdilution method | 2013 | European journal of medicinal chemistry, Jul, Volume: 65 | New linezolid-like 1,2,4-oxadiazoles active against Gram-positive multiresistant pathogens. |
| AID270148 | Antibacterial activity against gram positive vancomycin-resistant Enterococcus faecium OC 3312 | 2006 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 16, Issue:17 | Antibacterial activity of pyrrolopyridine-substituted oxazolidinones: synthesis and in vitro SAR of various C-5 acetamide replacements. |
| AID12301 | Half life of compound (25 mg/kg) after po administration was determined in Sprague-Dawley rat | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | The effect of remote chirality on the antibacterial activity of indolinyl, tetrahydroquinolyl and dihydrobenzoxazinyl oxazolidinones. |
| AID207680 | Minimum inhibitory concentration (MIC) against Staphylococcus aureus OC 4172 in the absence of mouse serum | 2004 | Bioorganic & medicinal chemistry letters, Jun-21, Volume: 14, Issue:12 | The synthesis and antimicrobial evaluation of a new series of isoxazolinyl oxazolidinones. |
| AID561076 | Antibacterial activity against community-acquired methicillin-resistant Staphylococcus aureus by CLSI M7-A7 broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | In vitro activity of TR-700, the active ingredient of the antibacterial prodrug TR-701, a novel oxazolidinone antibacterial agent. |
| AID1591542 | Antibacterial activity against penicillin-resistant Staphylococcus aureus clinical isolate incubated for 24 hrs by CLSI protocol based broth microdilution method | 2019 | Bioorganic & medicinal chemistry, 07-15, Volume: 27, Issue:14 | Discovery of 1,3,4-oxadiazol-2-one-containing benzamide derivatives targeting FtsZ as highly potent agents of killing a variety of MDR bacteria strains. |
| AID564833 | Antimicrobial activity against methicillin-susceptible coagulase-negative Staphylococcus hominis after 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID439888 | Antibacterial activity against Staphylococcus aureus ATCC 29737 after 18 hrs by agar dilution method | 2010 | European journal of medicinal chemistry, Jan, Volume: 45, Issue:1 | Synthesis and antibacterial activity of isothiazolyl oxazolidinones and analogous 3(2H)-isothiazolones. |
| AID562250 | Antibacterial activity against methicillin-resistant Staphylococcus aureus isolated form patient blood measured after 18 to 24 hrs on day 1 isolation by Etest | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Correlation between vancomycin MIC values and those of other agents against gram-positive bacteria among patients with bloodstream infections caused by methicillin-resistant Staphylococcus aureus. |
| AID565483 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus by broth microdilution method in presence of 50% human plasma | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro bactericidal activity of iclaprim in human plasma. |
| AID292671 | Antibacterial activity against Enterococcus faecalis by broth microdilution method | 2007 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 17, Issue:18 | A distal methyl substituent attenuates mitochondrial protein synthesis inhibition in oxazolidinone antibacterials. |
| AID1079949 | Proposed mechanism(s) of liver damage. [column 'MEC' in source] | |||
| AID1563585 | Inhibition of FabB/FabF in methicillin-sensitive Staphylococcus aureus assessed as antibacterial activity after 16 hrs by agar dilution method | 2019 | Journal of medicinal chemistry, 07-25, Volume: 62, Issue:14 | Late-Stage Functionalization of Platensimycin Leading to Multiple Analogues with Improved Antibacterial Activity in Vitro and in Vivo. |
| AID561752 | Antibacterial activity against Methicillin-resistant Staphylococcus aureus assessed as susceptible isolates by CLSI broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Potency and bactericidal activity of iclaprim against recent clinical gram-positive isolates. |
| AID697277 | Antibacterial activity against community acquired methicillin-resistant Staphylococcus aureus ARC 3189 after 18 to 24 hrs by CLSI broth microdilution method | 2012 | Journal of medicinal chemistry, Aug-09, Volume: 55, Issue:15 | Novel N-linked aminopiperidine inhibitors of bacterial topoisomerase type II with reduced pK(a): antibacterial agents with an improved safety profile. |
| AID1778093 | Antibacterial activity against Escherichia coli 25922 assessed as inhibition of bacterial growth incubated for 18 hrs by broth microdilution method | |||
| AID533959 | Antimicrobial activity against Staphylococcus aureus infected in THP1 cells after 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Cellular pharmacodynamics of the novel biaryloxazolidinone radezolid: studies with infected phagocytic and nonphagocytic cells, using Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Legionella pneumophila. |
| AID571995 | Antibacterial activity against Peptoniphilus asaccharolyticus by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID532783 | Antibacterial activity against vancomycin-susceptible Staphylococcus aureus MI after 24 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Improved antimicrobial activity of linezolid against vancomycin-intermediate Staphylococcus aureus. |
| AID584994 | Antibacterial activity against Staphylococcus aureus XU21-T1 harboring cfr-encoding conjugative pSCFS7 and fexA by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Identification and characterization of the multidrug resistance gene cfr in a Panton-Valentine leukocidin-positive sequence type 8 methicillin-resistant Staphylococcus aureus IVa (USA300) isolate. |
| AID1703728 | Antibacterial activity against Listeria monocytogenes ATCC 19111 assessed as inhibition of bacterial growth measured after 18 to 20 hrs by CLSI protocol based broth microdilution method | 2020 | European journal of medicinal chemistry, Sep-15, Volume: 202 | Evaluation of N-phenyl-2-aminothiazoles for treatment of multi-drug resistant and intracellular Staphylococcus aureus infections. |
| AID285379 | Bactericidal activity against vancomycin-intermediate Staphylococcus aureus Mu50 assessed as reduction of CFU using in vitro PK/PD model with human dosage regimen 120 mg every 12 hrs after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Pharmacokinetic/pharmacodynamic factors influencing emergence of resistance to linezolid in an in vitro model. |
| AID523802 | Antimicrobial activity against linezolid-susceptible Staphylococcus aureus assessed as inhibition of microbial growth at 2 ug/ml by CLSI method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative activities of TR-700 (torezolid) against staphylococcal blood isolates collected in Spain. |
| AID1519263 | Inhibition of human MAO-A at 30 uM relative to control | 2019 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 29, Issue:23 | Synthesis and antibacterial evaluation of novel oxazolidinone derivatives containing a piperidinyl moiety. |
| AID374006 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus 540 after 16 passages with quinupristin-dalfopristin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID284953 | Antimicrobial activity against Bacillus cereus at 0.25 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID528734 | Antibacterial activity against methicillin resistant coagulase-negative Staphylococcus haemolyticus clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID1539443 | Antibacterial activity against Methicillin-sensitive Staphylococcus aureus ATCC 6538 clinical isolates after 18 to 20 hrs in aerobic condition by CLSI protocol based broth microdilution assay | |||
| AID308912 | Antibacterial activity against Bacillus subtilis ATCC 6633 by broth microdilution method | 2007 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 17, Issue:18 | Synthesis and in vitro antibacterial activity of novel methylamino piperidinyl oxazolidinones. |
| AID524954 | Antibacterial activity against methicillin-susceptible coagulase-negative unspeciated Staphylococcus clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Comparative surveillance study of telavancin activity against recently collected gram-positive clinical isolates from across the United States. |
| AID562396 | Antimicrobial activity against oxacillin-resistant Staphylococcus aureus clinical isolates assessed as percent susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID285113 | Antimicrobial activity against viridans group Streptococcus oralis at 0.12 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID1710591 | Antibacterial activity against Listeria monocytogenes ATCC 19111 assessed as inhibition of visible bacterial growth incubated for 18 to 20 hrs by CLSI method | 2020 | RSC medicinal chemistry, Jan-01, Volume: 11, Issue:1 | Potent trifluoromethoxy, trifluoromethylsulfonyl, trifluoromethylthio and pentafluorosulfanyl containing (1,3,4-oxadiazol-2-yl)benzamides against drug-resistant Gram-positive bacteria. |
| AID1501359 | Antibacterial activity against methicillin-resistant Staphylococcus aureus USA200 NRS383 after 20 hrs by broth microdilution assay | 2017 | European journal of medicinal chemistry, Oct-20, Volume: 139 | Arylthiazole antibiotics targeting intracellular methicillin-resistant Staphylococcus aureus (MRSA) that interfere with bacterial cell wall synthesis. |
| AID283149 | Antimicrobial susceptibility of Staphylococcus lugdunensis isolates by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | In vitro effects of antimicrobial agents on planktonic and biofilm forms of Staphylococcus lugdunensis clinical isolates. |
| AID1151746 | Antibacterial activity against Staphylococcus aureus measured after 8 serial passages | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID373829 | Antimicrobial activity against panton-valentine leukocidin-positive community-acquired methicillin-resistant Staphylococcus aureus 490 after 17 passages with CG400549 measured after 10 antibiotic-free subculture by multi-step resistance selection techniqu | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID560829 | Ratio of Cmax in human adults with pulmonary tuberculosis at 600 mg administered twice daily for 5 days to MIC for Mycobacterium tuberculosis | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Population pharmacokinetics of linezolid in adults with pulmonary tuberculosis. |
| AID520489 | AUC in New Zealand rabbit at 20 mg/kg, sc administered every 6 hrs for 4 days measured after 1 hr post first dose by RP-HPLC/MS/MS | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Efficacies of ceftobiprole medocaril and comparators in a rabbit model of osteomyelitis due to methicillin-resistant Staphylococcus aureus. |
| AID608940 | Antibacterial activity against Staphylococcus aureus ATCC 9144 after 24 hrs by broth microdilution method | 2011 | European journal of medicinal chemistry, Jul, Volume: 46, Issue:7 | A regioselective synthesis of some new pyrazol-1'-ylpyrazolo[1,5-a]pyrimidines in aqueous medium and their evaluation as antimicrobial agents. |
| AID1677793 | Bacteriostatic activity against Staphylococcus aureus clinical isolate assessed as ratio of MBC to MIC | 2020 | Bioorganic & medicinal chemistry, 11-01, Volume: 28, Issue:21 | Design, synthesis of novel 4,5-dihydroisoxazole-containing benzamide derivatives as highly potent FtsZ inhibitors capable of killing a variety of MDR Staphylococcus aureus. |
| AID308487 | Antibacterial activity against Streptococcus pneumoniae SV1 SP3 | 2007 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 17, Issue:16 | Synthesis and SAR of novel conformationally restricted oxazolidinones possessing gram-positive and fastidious gram-negative antibacterial activity. Part 2: Amino substitutions on heterocyclic D-ring system. |
| AID535016 | Bactericidal activity against daptomycin-nonsusceptible Staphylococcus aureus assessed as antibiotic concentration that reduced the number of viable cells by =>99.9% by colony count method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | In vitro activity of ceftaroline against community-associated methicillin-resistant, vancomycin-intermediate, vancomycin-resistant, and daptomycin-nonsusceptible Staphylococcus aureus isolates. |
| AID548524 | Antimicrobial activity against Oxacillin-resistant Staphylococcus aureus assessed as percent resistant isolate by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Activities of dalbavancin against a worldwide collection of 81,673 gram-positive bacterial isolates. |
| AID576677 | Bactericidal activity against 2 hrs peripheral compartment culture samples of Enterococcus faecalis Ef1497 in two-compartment pharmacokinetic/pharmacodynamic model assessed as effect on bacterial count at 800 mg, bid administered as 0.5 hr infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID128015 | Compound was tested against Staphylococcus aureus UC9213 after po administration in mouse | 1998 | Journal of medicinal chemistry, Sep-10, Volume: 41, Issue:19 | Piperazinyl oxazolidinone antibacterial agents containing a pyridine, diazene, or triazene heteroaromatic ring. |
| AID524687 | Antibacterial activity against vancomycin-susceptible Enterococcus faecium clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro antibacterial activity of CE-156811, a novel analog derived from hygromycin A. |
| AID671567 | Antibacterial activity against methicillin-resistant Staphylococcus aureus VL-137 infected in neutropenic Balb/c mouse assessed as reduction in lung CFU at 50 mg/kg, po administered 2 and 12 hrs post infection measured 24 hrs post treatment | 2012 | Journal of medicinal chemistry, Jan-26, Volume: 55, Issue:2 | Fluorocyclines. 2. Optimization of the C-9 side-chain for antibacterial activity and oral efficacy. |
| AID525146 | Antimicrobial activity against Staphylococcus epidermidis isolate 426-3147L expressing cfr gene by Etest method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | First report of cfr-mediated resistance to linezolid in human staphylococcal clinical isolates recovered in the United States. |
| AID775532 | Inhibition of CYP2C9 in human liver microsomes assessed as tolbutamide hydroxylation after 20 mins by LC/MS/MS analysis | 2013 | European journal of medicinal chemistry, Nov, Volume: 69 | Synthesis and in vitro/in vivo antibacterial activity of oxazolidinones having thiocarbamate at C-5 on the A-ring and an amide- or urea-substituted [1,2,5]triazepane or [1,2,5]oxadiazepane as the C-ring. |
| AID1680045 | Antibacterial activity against NDM1 producing carbapenem-resistant Enterobacteriaceae clinical isolate 1 assessed as reduction in bacterial growth incubated for 16 to 20 hrs by CLSI-based broth microdilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Synthesis and antibacterial bioactivities of cationic deacetyl linezolid amphiphiles. |
| AID1151728 | Antibacterial activity against Streptococcus equisimilis | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID528720 | Antibacterial activity against vancomycin resistant Enterococcus faecalis VanB clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID564820 | Bactericidal activity against methicillin-susceptible Staphylococcus aureus after 24 hrs by plate counting method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID283399 | Antimicrobial activity against Nocardia brasiliensis after 72 hrs by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | In vitro activities of tigecycline and eight other antimicrobials against different Nocardia species identified by molecular methods. |
| AID541096 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 infected in Albino guiena pig assessed as cure rate at 75 mg/kg measured on day 4 postinfection | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Linezolid alone or combined with rifampin against methicillin-resistant Staphylococcus aureus in experimental foreign-body infection. |
| AID583387 | Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus isolate MU50 assessed as bacterial count at 4 times MIC after 24 hrs by colony counting method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | In vitro activity of the new multivalent glycopeptide-cephalosporin antibiotic TD-1792 against vancomycin-nonsusceptible Staphylococcus isolates. |
| AID319158 | Cmin in human at 625 mg, po bid after 14 days | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7 | Linezolid (ZYVOX), the first member of a completely new class of antibacterial agents for treatment of serious gram-positive infections. |
| AID561096 | Antibacterial activity against Peptostreptococcus micros by CLSI M11-A7 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | In vitro activity of TR-700, the active ingredient of the antibacterial prodrug TR-701, a novel oxazolidinone antibacterial agent. |
| AID1308224 | Antibacterial activity against mecA-positive multidrug resistant Staphylococcus aureus COL NRS100 incubated for 16 to 20 hrs by microdilution method | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10 | Structure-Activity Relationship for the 4(3H)-Quinazolinone Antibacterials. |
| AID523780 | Antimicrobial activity against oxacillin-resistant Staphylococcus aureus by CLSI method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative activities of TR-700 (torezolid) against staphylococcal blood isolates collected in Spain. |
| AID753115 | Antibacterial activity against Micrococcus luteus MTCC 2470 assessed as growth inhibition at 20 mg/mL after 24 hrs | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | Anti-tubercular agents. Part 7: a new class of diarylpyrrole-oxazolidinone conjugates as antimycobacterial agents. |
| AID561084 | Antibacterial activity against penicillin-intermediate Streptococcus pneumoniae by CLSI M7-A7 broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | In vitro activity of TR-700, the active ingredient of the antibacterial prodrug TR-701, a novel oxazolidinone antibacterial agent. |
| AID498891 | Half life in immunocompetent SKH1 mouse plasma at 50 mg/kg, po | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vivo activity of ceftobiprole in murine skin infections due to Staphylococcus aureus and Pseudomonas aeruginosa. |
| AID475002 | Antibacterial activity against vancomycin and Linezolid resistant Enterococcus faecalis LCB0007 by two fold serial dilution method | 2010 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 20, Issue:7 | Synthesis, crystal and antibacterial studies of diversely functionalized tetrahydropyridin-4-ol. |
| AID541095 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 infected in Albino guiena pig assessed as cure rate at 50 mg/kg measured on day 4 postinfection | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Linezolid alone or combined with rifampin against methicillin-resistant Staphylococcus aureus in experimental foreign-body infection. |
| AID1409847 | Antibacterial activity against vancomycin-intermediate Staphylococcus aureus Mu50 infected in BALB/c mouse assessed as reduction of bacterial burden in liver at 0.4 mg, ip bid for 3.5 days administered 6 hrs post bacterial infection measured 84 hrs post i | 2018 | ACS medicinal chemistry letters, Mar-08, Volume: 9, Issue:3 | Novel Staphyloxanthin Inhibitors with Improved Potency against Multidrug Resistant |
| AID558480 | Antimicrobial activity against heterogeneous vancomycin-intermediate Staphylococcus aureus 873 measured on day 10 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID1151713 | Antibacterial activity against methicillin-resistant Staphylococcus epidermidis | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID532810 | Antibacterial activity against vancomycin-susceptible Staphylococcus aureus BR4 after 24 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Improved antimicrobial activity of linezolid against vancomycin-intermediate Staphylococcus aureus. |
| AID571993 | Antibacterial activity against Anaerococcus tetradius by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID637969 | Antibacterial activity against Streptococcus pneumoniae expressing PenR gene after overnight incubation by twofold broth dilution technique in presence of 2.5% blood | 2012 | Bioorganic & medicinal chemistry, Jan-01, Volume: 20, Issue:1 | Efficient microwave-assisted synthesis, antibacterial activity and high fluorescence of 5 benzimidazolyl-2'-deoxyuridines. |
| AID390339 | Antimicrobial activity against Moraxella catarrhalis 557 | 2008 | Journal of natural products, Dec, Volume: 71, Issue:12 | Citreamicins with potent gram-positive activity. |
| AID1390478 | Antibacterial activity against linezolid-resistant Enterococcus faecalis ATCC 29212 | 2018 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 28, Issue:7 | Design, synthesis and biological evaluation of spiropyrimidinetriones oxazolidinone derivatives as antibacterial agents. |
| AID1873913 | Antibacterial activity against Escherichia coli incubated for 16 to 20 hrs by broth microdilution method | 2022 | European journal of medicinal chemistry, Aug-05, Volume: 238 | Design, synthesis and activity against drug-resistant bacteria evaluation of C-20, C-23 modified 5-O-mycaminosyltylonolide derivatives. |
| AID573134 | Antibacterial activity against erythromycin-nonsusceptible Streptococcus pyogenes by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID561080 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis by CLSI M7-A7 broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | In vitro activity of TR-700, the active ingredient of the antibacterial prodrug TR-701, a novel oxazolidinone antibacterial agent. |
| AID571800 | Antibacterial activity against Clostridium butyricum by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID388045 | Antibacterial activity against Staphylococcus aureus EP167 after 18 to 20 hrs by serial dilution method | 2008 | Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19 | Isolation, structure, and antibacterial activity of thiazomycin A, a potent thiazolyl peptide antibiotic from Amycolatopsis fastidiosa. |
| AID456044 | Antibacterial activity against penicillin-intermediate resistant Streptococcus pneumoniae after 18 hrs by twofold microbroth dilution method | 2009 | Bioorganic & medicinal chemistry, Oct-01, Volume: 17, Issue:19 | Design, synthesis and biological evaluations of novel 7-[3-(1-aminocycloalkyl)pyrrolidin-1-yl]-6-desfluoro-8-methoxyquinolones with potent antibacterial activity against multi-drug resistant Gram-positive bacteria. |
| AID523031 | Antimicrobial activity against vancomycin-nonsusceptible Staphylococcus aureus by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative in vitro antimicrobial activities of torezolid (TR-700), the active moiety of a new oxazolidinone, torezolid phosphate (TR-701), determination of tentative disk diffusion interpretive criteria, and quality control ranges. |
| AID467838 | Antibacterial activity against methicillin and vancomycin-resistant Staphylococcus aureus ATCC 29213 after 24 hrs by agar dilution method | 2009 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 19, Issue:23 | Novel 4-N-substituted aryl but-3-ene-1,2-dione derivatives of piperazinyloxazolidinones as antibacterial agents. |
| AID519995 | Antimicrobial activity against Streptococcus pneumoniae harboring erm(B) and mef(A) gene | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID562179 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus 547 after 48 passages by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID695448 | Cytotoxicity against human HeLa cell line after 72 hrs | 2011 | Journal of medicinal chemistry, May-12, Volume: 54, Issue:9 | Selenophene-containing inhibitors of type IIA bacterial topoisomerases. |
| AID558088 | Antimicrobial activity against Ureaplasma urealyticum isolated from human by two fold serial dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Comparative in vitro susceptibilities of human mycoplasmas and ureaplasmas to a new investigational ketolide, CEM-101. |
| AID745373 | Inhibition of MAO-B in rat forebrain using [14C]PEA as substrate at 30 uM incubated for 20 mins prior to substrate addition measured after 10 mins by liquid scintillation counting analysis relative to control | 2013 | European journal of medicinal chemistry, May, Volume: 63 | Antibacterial oxazolidinone analogues having a N-hydroxyacetyl-substituted seven-membered [1,2,5]triazepane or [1,2,5]oxadiazepane C-ring unit. |
| AID223280 | Dose required to cure 50% of Staphylococcus aureus infected mice when administered orally; value ranges from 2.9-8.5 | 2000 | Journal of medicinal chemistry, Mar-09, Volume: 43, Issue:5 | Substituent effects on the antibacterial activity of nitrogen-carbon-linked (azolylphenyl)oxazolidinones with expanded activity against the fastidious gram-negative organisms Haemophilus influenzae and Moraxella catarrhalis. |
| AID576651 | Bactericidal activity against 12 hrs peripheral compartment culture samples of Enterococcus faecalis ATCC 29212 in two-compartment pharmacokinetic/pharmacodynamic model assessed as effect on bacterial count at 200 mg, bid administered as 0.5 hr infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID1056338 | Inhibition of human CYP2C9 assessed as tolbutamide hydroxylation after 20 mins by LC-MS/MS analysis | 2013 | ACS medicinal chemistry letters, Nov-14, Volume: 4, Issue:11 | Potent oxazolidinone antibacterials with heteroaromatic C-ring substructure. |
| AID571796 | Antibacterial activity against Clostridium subterminale by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID575274 | Antimicrobial activity against Streptococcus agalactiae by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Comparative in vitro activity profiles of novel bis-indole antibacterials against gram-positive and gram-negative clinical isolates. |
| AID576412 | Total clearance in two-compartment pharmacokinetic/pharmacodynamic model at 600 mg, bid administered as 0.5 hrs infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID576900 | Ratio of AUC (0 to 24 hrs) to MIC for Enterococcus faecalis ATCC 29212 in two-compartment pharmacokinetic/pharmacodynamic model at 200 mg, bid administered as 0.5 hr infusion for 2 days | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID575948 | Antimicrobial activity against erythromycin-resistant Streptococcus pneumoniae assessed as resistant isolates by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Distribution of serotypes, genotypes, and resistance determinants among macrolide-resistant Streptococcus pneumoniae isolates. |
| AID368282 | AUC in rabbit plasma at 58 mg/kg infused every 12 hrs for 4 days | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vivo efficacy of ceftaroline (PPI-0903), a new broad-spectrum cephalosporin, compared with linezolid and vancomycin against methicillin-resistant and vancomycin-intermediate Staphylococcus aureus in a rabbit endocarditis model. |
| AID525144 | Antimicrobial activity against Staphylococcus epidermidis isolate 426-3147L expressing cfr gene by broth microdilution CLSI method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | First report of cfr-mediated resistance to linezolid in human staphylococcal clinical isolates recovered in the United States. |
| AID562252 | Antibacterial activity against methicillin-resistant Staphylococcus aureus isolated form patient blood measured after 18 to 24 hrs on day 1 isolation stratified with vancomycin MIC < 1.5 mh/L by Etest | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Correlation between vancomycin MIC values and those of other agents against gram-positive bacteria among patients with bloodstream infections caused by methicillin-resistant Staphylococcus aureus. |
| AID671566 | Antibacterial activity against Acinetobacter baumannii | 2012 | Journal of medicinal chemistry, Jan-26, Volume: 55, Issue:2 | Fluorocyclines. 2. Optimization of the C-9 side-chain for antibacterial activity and oral efficacy. |
| AID1904084 | Antibacterial activity against Acinetobacter baumannii 2208 ATCC 19606 | 2022 | European journal of medicinal chemistry, Apr-05, Volume: 233 | Alternative approaches utilizing click chemistry to develop next-generation analogs of solithromycin. |
| AID245024 | In vitro minimum inhibitory concentration against Escherichia coli (ATCC 25922) | 2005 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 15, Issue:12 | Synthesis and antibacterial activity of novel (un)substituted benzotriazolyl oxazolidinone derivatives. |
| AID283398 | Antimicrobial activity against Nocardia carnea after 72 hrs by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | In vitro activities of tigecycline and eight other antimicrobials against different Nocardia species identified by molecular methods. |
| AID574951 | Antimicrobial activity against Streptococcus pneumoniae serotype 7F by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID373747 | Antimicrobial activity against mupirocin-susceptible methicillin-resistant Staphylococcus aureus by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Mupirocin-resistant, methicillin-resistant Staphylococcus aureus strains in Canadian hospitals. |
| AID1151768 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis isolate EFL 4041 in po dosed mouse systemic infection model | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID576122 | Antibacterial activity against 7.5 x 10'8 CFU Haemophilus influenzae hd2 infected in ICR mouse systemic infection model assessed as mouse protection administered orally twice after 1 and 4 hrs post infection measured after 48 hrs | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | In vitro and in vivo activities of LCB01-0371, a new oxazolidinone. |
| AID373748 | Antimicrobial activity against mupirocin-resistant methicillin-resistant Staphylococcus aureus by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Mupirocin-resistant, methicillin-resistant Staphylococcus aureus strains in Canadian hospitals. |
| AID532786 | Antibacterial activity against vancomycin-intermediate Staphylococcus aureus BR4 after 24 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Improved antimicrobial activity of linezolid against vancomycin-intermediate Staphylococcus aureus. |
| AID1151717 | Antibacterial activity against coagulase-negative Staphylococcus | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID209475 | In vitro antibacterial activity against Streptococcus pyogenes strain UC 152 | 1996 | Journal of medicinal chemistry, Feb-02, Volume: 39, Issue:3 | Synthesis and antibacterial activity of U-100592 and U-100766, two oxazolidinone antibacterial agents for the potential treatment of multidrug-resistant gram-positive bacterial infections. |
| AID533961 | Antimicrobial activity against Listeria monocytogenes infected in THP1 cells after 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Cellular pharmacodynamics of the novel biaryloxazolidinone radezolid: studies with infected phagocytic and nonphagocytic cells, using Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Legionella pneumophila. |
| AID1168016 | Antibacterial activity against vancomycin-resistant Enterococcus faecium clinical isolate 27/221 after overnight incubation by two-fold serial dilution method | 2014 | Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21 | Synthesis and biological evaluation of novel peptide BF2 as an antibacterial agent against clinical isolates of vancomycin-resistant enterococci. |
| AID561736 | Antibacterial activity against Beta-hemolytic Streptococcus group B assessed as susceptible isolates by CLSI broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Potency and bactericidal activity of iclaprim against recent clinical gram-positive isolates. |
| AID1472609 | In vivo anti-virulence activity against Staphylococcus aureus Newman infected in BALB/c mouse model assessed as reduction in bacterial load in heart at 0.4 mg bid for 4.5 days administered intraperitoneally 6 hrs post infection by serial dilution method | 2018 | Journal of medicinal chemistry, 01-11, Volume: 61, Issue:1 | Novel Terminal Bipheny-Based Diapophytoene Desaturases (CrtN) Inhibitors as Anti-MRSA/VISR/LRSA Agents with Reduced hERG Activity. |
| AID1862427 | Antibacterial activity against methicillin-resistant Staphylococcus aureus USA 300 (ARLG 1569) assessed as reduction in visible bacterial growth incubated for 18 to 20 hrs by CLSI based broth microdilution analysis | 2022 | European journal of medicinal chemistry, Oct-05, Volume: 240 | Membrane acting Povarov-Doebner derived compounds potently disperse preformed multidrug resistant Gram-positive bacterial biofilms. |
| AID542893 | fAUC (24 hrs) in Bacillus anthracis infected in vitro hollow fiber PK/PD model at simulated dose of 200 mg administered every 12 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID574948 | Antimicrobial activity against Streptococcus pneumoniae serotype 19A by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID285043 | Antimicrobial activity against Corynebacterium striatum by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID571814 | Antibacterial activity against Clostridium sp. by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID1861539 | Clearance in Beagle dog at 15 mg/kg, iv | 2022 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 71 | WCK 4034: A promising oxazolidinone for treating gram positive infections. |
| AID285036 | Antimicrobial activity against Aerococcus spp. by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID533963 | Bacteriostatic activity against Staphylococcus aureus infected in THP1 cells after 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Cellular pharmacodynamics of the novel biaryloxazolidinone radezolid: studies with infected phagocytic and nonphagocytic cells, using Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Legionella pneumophila. |
| AID542695 | fT>MIC in Bacillus anthracis infected in vitro hollow fiber PK/PD model at simulated dose of 800 mg administered every 24 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID1591551 | Bactericidal activity against methicillin-resistant Staphylococcus aureus ATCC 43300 assessed as log reduction in viable bacterial count at 4 ug/ml incubated for 24 hrs by time-kill curve assay | 2019 | Bioorganic & medicinal chemistry, 07-15, Volume: 27, Issue:14 | Discovery of 1,3,4-oxadiazol-2-one-containing benzamide derivatives targeting FtsZ as highly potent agents of killing a variety of MDR bacteria strains. |
| AID297125 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis NCTC-12201 after 18 hrs by agar plate dilution method | 2007 | Journal of medicinal chemistry, Aug-23, Volume: 50, Issue:17 | Discovery of 1,4-dihydroxy-2-naphthoate [corrected] prenyltransferase inhibitors: new drug leads for multidrug-resistant gram-positive pathogens. |
| AID524944 | Antibacterial activity against methicillin-susceptible coagulase-negative Staphylococcus capitis clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Comparative surveillance study of telavancin activity against recently collected gram-positive clinical isolates from across the United States. |
| AID528703 | Antibacterial activity against Streptococcus oralis clinical isolate assessed as susceptibility level by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID283388 | Effect on mitochondrial mass in PBMCs from patient during hyperlactemic phase by citrate synthase method relative to control | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Reversible inhibition of mitochondrial protein synthesis during linezolid-related hyperlactatemia. |
| AID210352 | In vitro antibacterial activity against Streptococcus pneumoniae strains ATCC 6305 and 31573 (SPN). | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | New antibacterial tetrahydro-4(2H)-thiopyran and thiomorpholine S-oxide and S,S-dioxide phenyloxazolidinones. |
| AID1271203 | Solubility of compound at pH 1.2 by HPLC analysis | 2015 | ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11 | Design, Synthesis, and Identification of Silicon Incorporated Oxazolidinone Antibiotics with Improved Brain Exposure. |
| AID523049 | Antimicrobial activity against beta-lactamase positive Haemophilus influenzae by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative in vitro antimicrobial activities of torezolid (TR-700), the active moiety of a new oxazolidinone, torezolid phosphate (TR-701), determination of tentative disk diffusion interpretive criteria, and quality control ranges. |
| AID66578 | Antibacterial activity was determined against clinically isolated vancomycin-B resistant enterococci (VRE) strains (10 strains) | 2003 | Journal of medicinal chemistry, Mar-13, Volume: 46, Issue:6 | Synthesis and structure-activity relationships of 5-amino-6-fluoro-1-[(1R,2S)-2-fluorocyclopropan-1-yl]-8-methylquinolonecarboxylic acid antibacterials having fluorinated 7-[(3R)-3-(1-aminocyclopropan-1-yl)pyrrolidin-1-yl] substituents. |
| AID1151723 | Bactericidal activity against penicillin intermediate-sensitive Streptococcus pneumoniae | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID1367592 | Antibacterial activity against gram-negative wild type Escherichia coli MG1655 by CLSI broth microdilution method | 2017 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23 | Compound design guidelines for evading the efflux and permeation barriers of Escherichia coli with the oxazolidinone class of antibacterials: Test case for a general approach to improving whole cell Gram-negative activity. |
| AID571805 | Antibacterial activity against Clostridium leptum by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID520002 | Antimicrobial activity against Mycoplasma pneumoniae isolated from human respiratory tract by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID1549094 | Antibacterial activity against Staphylococcus aureus ATCC 29213 measured after 16 to 20 hrs by microdilution method | 2020 | Journal of medicinal chemistry, 05-28, Volume: 63, Issue:10 | Exploration of the Structural Space in 4(3 |
| AID524956 | Antibacterial activity against methicillin-resistant coagulase-negative Staphylococcus cohnii clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Comparative surveillance study of telavancin activity against recently collected gram-positive clinical isolates from across the United States. |
| AID591663 | Antimicrobial activity against multidrug-resistant Streptococcus pneumoniae after 18 hrs by agar dilution method | 2011 | Journal of medicinal chemistry, Apr-14, Volume: 54, Issue:7 | A new DNA gyrase inhibitor subclass of the cyclothialidine family based on a bicyclic dilactam-lactone scaffold. Synthesis and antibacterial properties. |
| AID1770342 | Antibacterial activity against erythromycin-susceptible Streptococcus pyogenes assessed as inhibition of bacterial growth measured after 20 hrs by two-fold microdilution assay | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Modification of 5-methylphenanthridium from benzothiazoles to indoles as potent FtsZ inhibitors: Broadening the antibacterial spectrum toward vancomycin-resistant enterococci. |
| AID573886 | Antibacterial activity against penicillin-susceptible Streptococcus pneumoniae ATCC 6301 infected in po dosed CF-1 mouse administered at 24 hrs post infection measured after 48 hrs relative to Linezolid | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | In vivo activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. |
| AID520017 | Antimicrobial activity against Staphylococcus capitis A8935 | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID112686 | In vivo antibacterial activity against Staphylococcus aures strain UC 9213 administered subcutaneously in mice | 1996 | Journal of medicinal chemistry, Feb-02, Volume: 39, Issue:3 | Synthesis and antibacterial activity of U-100592 and U-100766, two oxazolidinone antibacterial agents for the potential treatment of multidrug-resistant gram-positive bacterial infections. |
| AID369435 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus after 20 to 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vitro activity of telavancin against gram-positive clinical isolates recently obtained in Europe. |
| AID1647976 | Cytotoxicity against human A549 cells by CCK8 assay | 2020 | Journal of natural products, 02-28, Volume: 83, Issue:2 | The Isolation of Pyrroloformamide Congeners and Characterization of Their Biosynthetic Gene Cluster. |
| AID565750 | Antimicrobial activity against vancomycin-nonsusceptible Enterococcus faecalis clinical isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID1553379 | Cytotoxicity against human HepG2 cells assessed as reduction in cell viability by CellTiter-Glo assay | 2019 | Bioorganic & medicinal chemistry letters, 09-15, Volume: 29, Issue:18 | Incorporation of a chiral gem-disubstituted nitrogen heterocycle yields an oxazolidinone antibiotic with reduced mitochondrial toxicity. |
| AID1243930 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus USA700 assessed as reduction in bacterial growth incubated for 18 to 20 hrs at 37 degC by broth microdilution method | 2015 | European journal of medicinal chemistry, Aug-28, Volume: 101 | Discovery and characterization of aryl isonitriles as a new class of compounds versus methicillin- and vancomycin-resistant Staphylococcus aureus. |
| AID1327111 | Antibacterial activity against Staphylococcus aureus NCIM 2079 at 30 ug/ml measured after 12 hrs by spectrophotometric method | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Design, synthesis and biological evaluation of novel azaspiro analogs of linezolid as antibacterial and antitubercular agents. |
| AID285055 | Antimicrobial activity against beta hemolytic Streptococcus group C at 0.25 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID525134 | Antibacterial activity against Staphylococcus aureus KM51 after 18 to 24 hrs by broth microdilution method selected after 16 ug/ml drug exposure for 6 hrs by culture absorbance method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Delayed development of linezolid resistance in Staphylococcus aureus following exposure to low levels of antimicrobial agents. |
| AID1395981 | Bactericidal activity against methicillin-resistant Staphylococcus aureus 2 planktonic cells after 24 hrs by calgary biofilm device method | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9 | An Efficient Buchwald-Hartwig/Reductive Cyclization for the Scaffold Diversification of Halogenated Phenazines: Potent Antibacterial Targeting, Biofilm Eradication, and Prodrug Exploration. |
| AID524718 | Antibacterial activity against linezolid-resistant Staphylococcus aureus 01A1220 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro antibacterial activity of CE-156811, a novel analog derived from hygromycin A. |
| AID572006 | Antibacterial activity against Bacteroides vulgatus by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID558470 | Antimicrobial activity against heterogeneous vancomycin-intermediate Staphylococcus aureus 873 measured on day 5 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID576426 | Antibacterial activity against Staphylococcus aureus RN4220 MutS2 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID582988 | Antimicrobial activity against glycopeptide-resistant Enterococcus faecalis isolate HS07261 harboring MLST sequence type ST78 and pulsotype D expressing vanM gene cluster isolated from urine of patient by Etest | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | vanM, a new glycopeptide resistance gene cluster found in Enterococcus faecium. |
| AID1591545 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 incubated for 24 hrs by CLSI protocol based broth microdilution method | 2019 | Bioorganic & medicinal chemistry, 07-15, Volume: 27, Issue:14 | Discovery of 1,3,4-oxadiazol-2-one-containing benzamide derivatives targeting FtsZ as highly potent agents of killing a variety of MDR bacteria strains. |
| AID572017 | Antibacterial activity against Prevotella intermedia by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID1361113 | Bactericidal activity against vancomycin-resistant Staphylococcus aureus VRS12 clinical isolate preincubated for 20 hrs followed by TSA plating and measured after 18 hrs | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | N-(1,3,4-oxadiazol-2-yl)benzamide analogs, bacteriostatic agents against methicillin- and vancomycin-resistant bacteria. |
| AID522934 | Antibacterial activity against vancomycin-resistant Staphylococcus aureus isolate 510 after 24 hrs by modified broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Antistaphylococcal activity of ACHN-490 tested alone and in combination with other agents by time-kill assay. |
| AID1308226 | Antibacterial activity against mecA-positive multidrug resistant Staphylococcus aureus NRS120 incubated for 16 to 20 hrs by microdilution method | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10 | Structure-Activity Relationship for the 4(3H)-Quinazolinone Antibacterials. |
| AID533949 | Antimicrobial activity against methicillin-resistant, vancomycin intermediate Staphylococcus aureus NRS18 after 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Cellular pharmacodynamics of the novel biaryloxazolidinone radezolid: studies with infected phagocytic and nonphagocytic cells, using Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Legionella pneumophila. |
| AID532803 | Antibacterial activity against vancomycin-susceptible Staphylococcus aureus 99/3759-V after 24 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Improved antimicrobial activity of linezolid against vancomycin-intermediate Staphylococcus aureus. |
| AID285325 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus ATCC 29213 | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | In vitro activity of aurein 1.2 alone and in combination with antibiotics against gram-positive nosocomial cocci. |
| AID573123 | Antibacterial activity against coagulase-negative and oxacillin-resistant Staphylococcus aureus assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID1852672 | Antibacterial activity against multidrug resistant Acinetobacter baumannii Ab5075 assessed as inhibition of bacterial growth incubated for 24 hrs in M9-MOPS medium by twofold serial dilution method | |||
| AID1350031 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus isolate 2 incubated overnight by agar dilution method | 2018 | Journal of natural products, 02-23, Volume: 81, Issue:2 | Biomimetic Stereoselective Sulfa-Michael Addition Leads to Platensimycin and Platencin Sulfur Analogues against Methicillin-Resistant Staphylococcus aureus. |
| AID295155 | Antibacterial activity against methicillin-resistant Staphylococcus aureus by microdilution broth method | 2007 | European journal of medicinal chemistry, Aug, Volume: 42, Issue:8 | Synthesis and antibacterial activity of oxazolidinones containing triazolyl group. |
| AID1079936 | Choleostatic liver toxicity, either proven histopathologically or where the ratio of maximal ALT or AST activity above normal to that of Alkaline Phosphatase is < 2 (see ACUTE). Value is number of references indexed. [column 'CHOLE' in source] | |||
| AID576134 | Antibacterial activity against 10'4 to 10'5 CFU vancomycin-resistant Enterococcus after 18 hrs by CLSI 2-fold agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | In vitro and in vivo activities of LCB01-0371, a new oxazolidinone. |
| AID645046 | Antibacterial activity against Escherichia coli 3350 after 16 to 20 hrs by microbroth dilution method | 2012 | European journal of medicinal chemistry, Apr, Volume: 50 | Synthesis and preliminary antibacterial evaluation of Linezolid-like 1,2,4-oxadiazole derivatives. |
| AID1723492 | Antibacterial activity against Enterococcus faecium NR-28978 incubated for 18 to 20 hrs under aerobic condition by CLSI protocol based broth microdilution assay | |||
| AID571834 | Antibacterial activity against Ruminococcus luti by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID206146 | In vitro antibacterial activity against S. a. 035 (Staphylococcus aureus ATCC 29213) | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | Influence of ethylene-oxy spacer group on the activity of linezolid: synthesis of potent antibacterials possessing a thiocarbonyl group. |
| AID571795 | Antibacterial activity against Clostridium ramosum by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID1272264 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus MMX 2002 after 18 to 20 hrs by microdilution method | 2016 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 26, Issue:3 | A stepwise dechlorination/cross-coupling strategy to diversify the vancomycin 'in-chloride'. |
| AID373841 | Antimicrobial activity against vancomycin-resistant Staphylococcus aureus 509 Michigan after 28 passages with Linezolid measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID577103 | AUBC (0 to 24 hrs) in Staphylococcus aureus RN4220MutS2 in two-compartment pharmacokinetic/pharmacodynamic model at 600 mg, bid administered as 0.5 hr infusion for 2 days | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID562630 | Antimicrobial activity against Group G Streptococcus by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | In vitro activities of three new dihydrofolate reductase inhibitors against clinical isolates of gram-positive bacteria. |
| AID528968 | Antimicrobial activity against methicillin-susceptible Staphylococcus epidermidis assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID562619 | Antimicrobial activity against Heterovancomycin-resistant Staphylococcus aureus assessed as susceptible isolates by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | In vitro activities of three new dihydrofolate reductase inhibitors against clinical isolates of gram-positive bacteria. |
| AID571827 | Antibacterial activity against Eggerthella lenta by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID533989 | Bacteriostatic activity against linezolid-resistant Staphylococcus aureus SA238L infected in THP1 cells after 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Cellular pharmacodynamics of the novel biaryloxazolidinone radezolid: studies with infected phagocytic and nonphagocytic cells, using Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Legionella pneumophila. |
| AID1374172 | Antibacterial activity against Streptococcus pyogenes ATCC 19615 incubated at 37 degC for 20 hrs by agar dilution method | 2018 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4 | Design, synthesis and antibacterial evaluation of honokiol derivatives. |
| AID1703720 | Antibacterial activity against vancomycin-resistant Staphylococcus aureus 12 assessed as inhibition of bacterial growth measured after 18 to 20 hrs by CLSI protocol based broth microdilution method | 2020 | European journal of medicinal chemistry, Sep-15, Volume: 202 | Evaluation of N-phenyl-2-aminothiazoles for treatment of multi-drug resistant and intracellular Staphylococcus aureus infections. |
| AID1151771 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus ATCC 29213 in mouse thigh infection model assessed as reduction of log10 CFU per thigh at 5 mg/kg, po | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID1594383 | Cmax in human at 625 mg, po | 2019 | Bioorganic & medicinal chemistry, 05-01, Volume: 27, Issue:9 | Second-generation aryl isonitrile compounds targeting multidrug-resistant Staphylococcus aureus. |
| AID763949 | Antibacterial activity against Moraxella catarrhalis clinical isolate 2824 after 18 hrs by NCCLS agar dilution method | 2013 | European journal of medicinal chemistry, Aug, Volume: 66 | Synthesis and antibacterial activities of N-substituted-glycinyl 1H-1,2,3-triazolyl oxazolidinones. |
| AID1390475 | Antibacterial activity against TolC-deficient Escherichia coli | 2018 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 28, Issue:7 | Design, synthesis and biological evaluation of spiropyrimidinetriones oxazolidinone derivatives as antibacterial agents. |
| AID542888 | fT>MIC in Bacillus anthracis infected in vitro hollow fiber PK/PD model at simulated dose of 800 mg administered as 4 divided doses every 6 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID531570 | Antibacterial activity against Streptococcus sp. 'group G' obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID542675 | fCmax in Bacillus anthracis infected in vitro hollow fiber PK/PD model at simulated dose of 400 mg administered every 24 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID576901 | Ratio of AUC (0 to 24 hrs) to MIC for Enterococcus faecalis ATCC 29212 in two-compartment pharmacokinetic/pharmacodynamic model at 600 mg, bid administered as 0.5 hr infusion for 2 days | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID1434680 | Anti-bacterial activity against methicillin-resistant Staphylococcus aureus CCARM 3090 by 2-fold microtiter broth dilution method | 2017 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 27, Issue:3 | Cadiolides J-M, antibacterial polyphenyl butenolides from the Korean tunicate Pseudodistoma antinboja. |
| AID1553385 | Inhibition of COX1 (unknown origin) by ELISA | 2019 | Bioorganic & medicinal chemistry letters, 09-15, Volume: 29, Issue:18 | Incorporation of a chiral gem-disubstituted nitrogen heterocycle yields an oxazolidinone antibiotic with reduced mitochondrial toxicity. |
| AID283613 | Antimicrobial activity against Enterococcus faecalis 45 with heterozygous 23S rRNA G2576U mutation | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | In vitro activity of the oxazolidinone RWJ-416457 against linezolid-resistant and -susceptible staphylococci and enterococci. |
| AID511303 | Antibacterial activity against ciprofloxacin susceptible and methicillin resistant Staphylococcus aureus by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Comparative in vitro activities of nemonoxacin (TG-873870), a novel nonfluorinated quinolone, and other quinolones against clinical isolates. |
| AID524727 | Antibacterial activity against linezolid-resistant Enterococcus faecium 03B1076 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro antibacterial activity of CE-156811, a novel analog derived from hygromycin A. |
| AID1327102 | Antitubercular activity against dormant stage Mycobacterium tuberculosis H37Ra measured after 12 days by XTT assay | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Design, synthesis and biological evaluation of novel azaspiro analogs of linezolid as antibacterial and antitubercular agents. |
| AID528708 | Antibacterial activity against multidrug-resistant Streptococcus pneumoniae clinical isolate assessed as susceptibility level by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID434137 | Inhibition of MAOB | 2009 | European journal of medicinal chemistry, Sep, Volume: 44, Issue:9 | Knowledge based identification of MAO-B selective inhibitors using pharmacophore and structure based virtual screening models. |
| AID283163 | Antimicrobial susceptibility of Staphylococcus lugdunensis IDRL2639 biofilms after 24 hrs assessed as bacterial regrowth | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | In vitro effects of antimicrobial agents on planktonic and biofilm forms of Staphylococcus lugdunensis clinical isolates. |
| AID573887 | AUC (0 to 24 hrs) in CF-1 mouse at 2 mg/kg, iv | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | In vivo activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. |
| AID262237 | Antibacterial activity against Streptococcus pyogenes ATCC 14289 | 2006 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 16, Issue:6 | Novel 4-N-substituted aryl pent-2-ene-1,4-dione derivatives of piperazinyloxazolidinones as antibacterials. |
| AID532801 | Antibacterial activity against vancomycin-susceptible Staphylococcus aureus IL after 24 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Improved antimicrobial activity of linezolid against vancomycin-intermediate Staphylococcus aureus. |
| AID522916 | Antibacterial activity against hospital-acquired methicillin-resistant Staphylococcus aureus isolate 1851 after 24 hrs by modified broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Antistaphylococcal activity of ACHN-490 tested alone and in combination with other agents by time-kill assay. |
| AID535018 | Antimicrobial activity against vancomycin intermediate Staphylococcus aureus NRS-3 expressing SCCmec type 2 element by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | In vitro activity of ceftaroline against community-associated methicillin-resistant, vancomycin-intermediate, vancomycin-resistant, and daptomycin-nonsusceptible Staphylococcus aureus isolates. |
| AID630560 | Antibacterial activity against linezolid-resistant Staphylococcus epidermidis after 16 hrs by agar dilution method | 2011 | Journal of medicinal chemistry, Nov-10, Volume: 54, Issue:21 | Design, synthesis, and structure-activity relationship studies of highly potent novel benzoxazinyl-oxazolidinone antibacterial agents. |
| AID444050 | Fraction unbound in human plasma | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3 | Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. |
| AID534161 | Antimicrobial activity against linezolid-resistant Staphylococcus hominis by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains. |
| AID571802 | Antibacterial activity against Clostridium disporicum by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID524691 | Antibacterial activity against Streptococcus pyogenes clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro antibacterial activity of CE-156811, a novel analog derived from hygromycin A. |
| AID262232 | Antibacterial activity against Staphylococcus aureus ATCC 29213 | 2006 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 16, Issue:6 | Novel 4-N-substituted aryl pent-2-ene-1,4-dione derivatives of piperazinyloxazolidinones as antibacterials. |
| AID509631 | Antimicrobial activity against Staphylococcus aureus RN4220 transformant carrying plasmid pKKS25 and expressing erm(T), dfrK and tet(L) genes by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Identification of a plasmid-borne resistance gene cluster comprising the resistance genes erm(T), dfrK, and tet(L) in a porcine methicillin-resistant Staphylococcus aureus ST398 strain. |
| AID1584837 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis BM 4390 after 18 to 24 hrs by microdilution assay | 2018 | European journal of medicinal chemistry, Nov-05, Volume: 159 | 1-(2-Hydroxybenzoyl)-thiosemicarbazides are promising antimicrobial agents targeting d-alanine-d-alanine ligase in bacterio. |
| AID1877892 | Antibacterial activity against Mycobacterium smegmatis mc2 155 assessed as bacterial growth inhibition | 2022 | Bioorganic & medicinal chemistry letters, 03-01, Volume: 59 | Novel 2,4-disubstituted quinazoline analogs as antibacterial agents with improved cytotoxicity profile: Modification of the benzenoid part. |
| AID1186428 | Antimicrobial activity against Staphylococcus aureus ATCC 19636 infected in neutropenic mouse assessed as reduction in colony forming units at 25 mg/kg, iv administered as single dose measured 24 hrs post infection relative to control | 2014 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 24, Issue:17 | Discovery and in vivo evaluation of alcohol-containing benzothiazoles as potent dual-targeting bacterial DNA supercoiling inhibitors. |
| AID519091 | Antimicrobial activity against Staphylococcus aureus KM168 harboring Arg149Ser mutation in rplC gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Linezolid and tiamulin cross-resistance in Staphylococcus aureus mediated by point mutations in the peptidyl transferase center. |
| AID285041 | Antimicrobial activity against Corynebacterium jeikeium by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID520001 | Antimicrobial activity against Haemophilus influenzae | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID524967 | Antibacterial activity against vancomycin- and teichoplanin-nonsusceptible Enterococcus faecalis clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Comparative surveillance study of telavancin activity against recently collected gram-positive clinical isolates from across the United States. |
| AID133302 | Minimum inhibitory concentration of the subcutaneously administered compound evaluated against Staphylococcus pneumoniae PW3 strain in mice (SC) | 2000 | Bioorganic & medicinal chemistry letters, Aug-07, Volume: 10, Issue:15 | Improved antibacterial activities of coumarin antibiotics bearing 5',5'-dialkylnoviose: biological activity of RU79115. |
| AID576670 | Bactericidal activity against 12.5 hrs peripheral compartment culture samples of Enterococcus faecalis Ef1497 in two-compartment pharmacokinetic/pharmacodynamic model assessed as effect on bacterial count at 600 mg, bid administered as 0.5 hr infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID545804 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus ATCC 33591 planktonic cells by broth microdilution method in presence of 0.002% polysorbate 80 | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Oritavancin kills stationary-phase and biofilm Staphylococcus aureus cells in vitro. |
| AID535006 | Bactericidal activity against vancomycin-intermediate Staphylococcus aureus assessed as antibiotic concentration that reduced the number of viable cells by =>99.9% by colony count method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | In vitro activity of ceftaroline against community-associated methicillin-resistant, vancomycin-intermediate, vancomycin-resistant, and daptomycin-nonsusceptible Staphylococcus aureus isolates. |
| AID559774 | Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID523032 | Antimicrobial activity against methicillin-susceptible coagulase-negative Staphylococcus by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative in vitro antimicrobial activities of torezolid (TR-700), the active moiety of a new oxazolidinone, torezolid phosphate (TR-701), determination of tentative disk diffusion interpretive criteria, and quality control ranges. |
| AID523781 | Antimicrobial activity against oxacillin-resistant Staphylococcus aureus assessed as percent susceptible strain by CLSI method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative activities of TR-700 (torezolid) against staphylococcal blood isolates collected in Spain. |
| AID565758 | Antimicrobial activity against Staphylococcus epidermidis clinical isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID575273 | Antimicrobial activity against penicillin-resistant Streptococcus pneumoniae by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Comparative in vitro activity profiles of novel bis-indole antibacterials against gram-positive and gram-negative clinical isolates. |
| AID577131 | Mean residence time in two-compartment pharmacokinetic/pharmacodynamic model at 600 mg, bid administered as 0.5 hr infusion over 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID1557277 | Antitubercular activity against multidrug resistant Mycobacterium tuberculosis | 2019 | MedChemComm, Aug-01, Volume: 10, Issue:8 | Drug-resistance in |
| AID245273 | Minimum inhibitory concentration against Staphylococcus aureus ATCC 13709 (+4% BSA); value ranges from 3-6 uM | 2004 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 14, Issue:22 | Aryl urea analogs with broad-spectrum antibacterial activity. |
| AID285136 | Antimicrobial activity against viridans group Streptococcus vestibularis at <= 0.06 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID1395704 | Bactericidal activity against methicillin-sensitive Staphylococcus aureus NRS107 incubated fo 18 hrs followed by re-plating on tryptic soy agar plates at 37 degC for 18 hrs by broth microdilution assay | 2018 | European journal of medicinal chemistry, May-10, Volume: 151 | Phenylthiazoles with tert-Butyl side chain: Metabolically stable with anti-biofilm activity. |
| AID311481 | Antimicrobial activity against vancomycin-sensitive Enterococcus faecalis ATCC 29212 after 14 to 16 hrs by serial microbroth dilution method | 2007 | Journal of natural products, Sep, Volume: 70, Issue:9 | Lipoxazolidinones A, B, and C: antibacterial 4-oxazolidinones from a marine actinomycete isolated from a Guam marine sediment. |
| AID577107 | AUBC (0 to 24 hrs) in Enterococcus faecalis Ef1497 in two-compartment pharmacokinetic/pharmacodynamic model at 800 mg, bid administered as 0.5 hr infusion for 2 days | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID1265135 | Inhibition of human recombinant MAO-A using p-tyramine as substrate at 50 to 200 uM measured up to 50 mins by ELISA screening analysis | 2015 | European journal of medicinal chemistry, Dec-01, Volume: 106 | Synthesis and biological evaluation of novel 5-(hydroxamic acid)methyl oxazolidinone derivatives. |
| AID511434 | Antimicrobial activity against Clostridium perfringens LFM1 assessed as resistant breakpoint by EUCAST method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Resistance to linezolid in a porcine Clostridium perfringens strain carrying a mutation in the rplD gene encoding the ribosomal protein L4. |
| AID285069 | Antimicrobial activity against beta hemolytic Streptococci group G at 1 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID517666 | Antimicrobial activity against Staphylococcus aureus Smith by standard serial-dilution technique | 2010 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 20, Issue:20 | Bottromycin derivatives: efficient chemical modifications of the ester moiety and evaluation of anti-MRSA and anti-VRE activities. |
| AID523029 | Antimicrobial activity against Staphylococcus sp. by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative in vitro antimicrobial activities of torezolid (TR-700), the active moiety of a new oxazolidinone, torezolid phosphate (TR-701), determination of tentative disk diffusion interpretive criteria, and quality control ranges. |
| AID165190 | In vitro antibacterial activity against Pseudomonas aeruginosa strain ATCC 27853 | 1996 | Journal of medicinal chemistry, Feb-02, Volume: 39, Issue:3 | Synthesis and antibacterial activity of U-100592 and U-100766, two oxazolidinone antibacterial agents for the potential treatment of multidrug-resistant gram-positive bacterial infections. |
| AID524686 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro antibacterial activity of CE-156811, a novel analog derived from hygromycin A. |
| AID278930 | Antibacterial activity against methicillin-resistant Staphylococcus aureus OC 2878 by time kill experiments | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | In vitro antibacterial activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. |
| AID560832 | fT>MIC in human adults with pulmonary tuberculosis at 600 mg administered twice daily for 5 days | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Population pharmacokinetics of linezolid in adults with pulmonary tuberculosis. |
| AID520482 | Toxicity in methicillin-resistant Staphylococcus aureus-infected New Zealand rabbit osteomyelitis model assessed as body weight at 30 mg/kg, sc administered every 12 hrs for 4 days measured on week 6 postinfection (Rvb = 2.84 +/- 0.30 kg) | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Efficacies of ceftobiprole medocaril and comparators in a rabbit model of osteomyelitis due to methicillin-resistant Staphylococcus aureus. |
| AID745375 | Inhibition of human CYP3A4 assessed as terfenadine hydroxylation after 20 mins by LC/MS/MS analysis | 2013 | European journal of medicinal chemistry, May, Volume: 63 | Antibacterial oxazolidinone analogues having a N-hydroxyacetyl-substituted seven-membered [1,2,5]triazepane or [1,2,5]oxadiazepane C-ring unit. |
| AID571807 | Antibacterial activity against Clostridium paraputrificum by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID1474209 | Bactericidal activity against Enterococcus faecalis clinical isolates after 18 to 22 hrs by broth microdilution method | 2017 | Journal of medicinal chemistry, 03-23, Volume: 60, Issue:6 | Phenylthiazole Antibacterial Agents Targeting Cell Wall Synthesis Exhibit Potent Activity in Vitro and in Vivo against Vancomycin-Resistant Enterococci. |
| AID206435 | In vitro antibacterial activity against ciprofloxacin and methicillin resistant Staphylococcus aureus (Sau2CIP) was determined | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | Structure-activity relationship in the oxazolidinone-quinolone hybrid series: influence of the central spacer on the antibacterial activity and the mode of action. |
| AID373835 | Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus 504 after 50 passages with daptomycin measured after 10 times antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID533428 | Antimicrobial activity against Peptostreptococcus sp. assessed as resistant isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activities of doripenem, a new broad-spectrum carbapenem, against recently collected clinical anaerobic isolates, with emphasis on the Bacteroides fragilis group. |
| AID424756 | Antibacterial activity against macrolide, imipenem, methicillin-resistant Staphylococcus aureus MB5393 after 20 hrs by twofold serial broth dilution method | 2009 | Journal of natural products, May-22, Volume: 72, Issue:5 | Thiazomycins, thiazolyl peptide antibiotics from Amycolatopsis fastidiosa. |
| AID558708 | Antimicrobial activity against heterogeneous vancomycin-intermediate Staphylococcus aureus 873 measured on day 40 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID284974 | Antimicrobial activity against Corynebacterium pseudodiphtheriticum at 0.5 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID571816 | Antibacterial activity against Bifidobacterium adolescentis by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID523025 | Antimicrobial activity against linezolid-resistant Staphylococcus aureus by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative in vitro antimicrobial activities of torezolid (TR-700), the active moiety of a new oxazolidinone, torezolid phosphate (TR-701), determination of tentative disk diffusion interpretive criteria, and quality control ranges. |
| AID523047 | Antimicrobial activity against Haemophilus influenzae by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative in vitro antimicrobial activities of torezolid (TR-700), the active moiety of a new oxazolidinone, torezolid phosphate (TR-701), determination of tentative disk diffusion interpretive criteria, and quality control ranges. |
| AID573155 | Antibacterial activity against vancomycin-resistant Enterococcus faecium by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID373308 | Antibacterial activity against methicillin-resistant Staphylococcus aureus clinical isolate after 18 hrs by NCCLS M7-A4 method | 2009 | European journal of medicinal chemistry, Mar, Volume: 44, Issue:3 | Synthesis, antibacterial and anticonvulsant evaluations of some cyclic enaminones. |
| AID1076822 | Antitubercular activity against multidrug-resistant Mycobacterium tuberculosis clinical isolate 3 assessed as growth inhibition by microdilution method | 2014 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 24, Issue:6 | Discovery of novel bis-oxazolidinone compounds as potential potent and selective antitubercular agents. |
| AID1677805 | Antibacterial activity against penicillin-resistant Staphylococcus aureus incubated for 24 hrs by CLSI-based broth microdilution method | 2020 | Bioorganic & medicinal chemistry, 11-01, Volume: 28, Issue:21 | Design, synthesis of novel 4,5-dihydroisoxazole-containing benzamide derivatives as highly potent FtsZ inhibitors capable of killing a variety of MDR Staphylococcus aureus. |
| AID326499 | Antibacterial activity against vancomycin-susceptible Enterococcus faecalis JH2-2 after 24 hrs by broth macrodilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Single-dose oral amoxicillin or linezolid for prophylaxis of experimental endocarditis due to vancomycin-susceptible and vancomycin-resistant Enterococcus faecalis. |
| AID533012 | Antibacterial activity against vancomycin-intermediate Staphylococcus aureus BR3 phenotypic revertant after 24 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Improved antimicrobial activity of linezolid against vancomycin-intermediate Staphylococcus aureus. |
| AID571767 | Antimicrobial activity against Escherichia coli K-12 3-AG300 harboring AcrB-615-628MexB-M626I mutant gene | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Site-directed mutagenesis reveals amino acid residues in the Escherichia coli RND efflux pump AcrB that confer macrolide resistance. |
| AID561098 | Antibacterial activity against Prevotella sp. by CLSI M11-A7 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | In vitro activity of TR-700, the active ingredient of the antibacterial prodrug TR-701, a novel oxazolidinone antibacterial agent. |
| AID285101 | Antimicrobial activity against viridans group Streptococcus mitis at 0.12 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID581655 | Antibacterial activity against Staphylococcus aureus SCV isolated from cystic fibrosis patient at pH 7.4 after 48 hrs by broth microdilution method in presence of thymidine | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Intracellular activity of antibiotics in a model of human THP-1 macrophages infected by a Staphylococcus aureus small-colony variant strain isolated from a cystic fibrosis patient: pharmacodynamic evaluation and comparison with isogenic normal-phenotype a |
| AID1578433 | Antimicrobial activity against methicillin-resistant Streptococcus pneumoniae ATCC 700677 by broth liquid microdilution method | 2020 | European journal of medicinal chemistry, Jan-01, Volume: 185 | Modifying the lipophilic part of phenylthiazole antibiotics to control their drug-likeness. |
| AID274227 | Antibacterial activity against Enterococcus faecalis MGH-2 EF1-1 | 2006 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 16, Issue:20 | Synthesis and structure-activity studies of novel benzocycloheptanone oxazolidinone antibacterial agents. |
| AID590152 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus Smith infected iv dosed ICR mouse assessed as protection against mouse mortality administered 1 hr after infection measured up to 7 days | 2011 | European journal of medicinal chemistry, Apr, Volume: 46, Issue:4 | Discovery of torezolid as a novel 5-hydroxymethyl-oxazolidinone antibacterial agent. |
| AID1076833 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus ATCC 29213 assessed as growth inhibition after 18 hrs by broth microdilution method | 2014 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 24, Issue:6 | Discovery of novel bis-oxazolidinone compounds as potential potent and selective antitubercular agents. |
| AID1680009 | Induction of inner membrane permeabilization in Staphylococcus aureus ATCC 29213 at 20 ug/ml measured for 12 mins by propidium iodide staining based fluorescence microscopic analysis | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Synthesis and antibacterial bioactivities of cationic deacetyl linezolid amphiphiles. |
| AID1770348 | Antibacterial activity against erythromycin-resistant Streptococcus pyogenes assessed as inhibition of bacterial growth measured after 20 hrs by two-fold microdilution assay | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Modification of 5-methylphenanthridium from benzothiazoles to indoles as potent FtsZ inhibitors: Broadening the antibacterial spectrum toward vancomycin-resistant enterococci. |
| AID285384 | Antibacterial activity against heteroresistant vancomycin-intermediate Staphylococcus aureus Mu3 using in vitro PK/PD model with 120 mg/24 hr continuous infusion simulated regimen after 72 hrs | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Pharmacokinetic/pharmacodynamic factors influencing emergence of resistance to linezolid in an in vitro model. |
| AID576896 | Ratio of Cmax to MIC for 0.5 hrs peripheral compartment culture samples of Enterococcus faecalis Ef1497 MutM3 in two-compartment pharmacokinetic/pharmacodynamic model at 600 mg, bid administered as 0.5 hr infusion for 2 days | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID1076821 | Antitubercular activity against extensive drug-resistant Mycobacterium tuberculosis clinical isolate 4 assessed as growth inhibition by microdilution method | 2014 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 24, Issue:6 | Discovery of novel bis-oxazolidinone compounds as potential potent and selective antitubercular agents. |
| AID374003 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus 540 after 14 passages with CG400549 measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID595861 | Antibacterial activity against methicillin-resistant Staphylococcus aureus clinical isolate after 24 hrs by microdilution method | 2011 | Journal of medicinal chemistry, May-12, Volume: 54, Issue:9 | Exploration of the activity of 7-pyrrolidino-8-methoxyisothiazoloquinolones against methicillin-resistant Staphylococcus aureus (MRSA). |
| AID1329445 | Antibacterial activity against linezolid-resistant Mycobacterium tuberculosis H37Rv in hollow-fiber infection model assessed as reduction in bacterial burden at 600 mg, po at 24 hrs dose regimen measured after 3 weeks | 2016 | Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24 | From lead optimization to NDA approval for a new antimicrobial: Use of pre-clinical effect models and pharmacokinetic/pharmacodynamic mathematical modeling. |
| AID1361051 | Antibacterial activity against vancomycin-resistant Enterococcus faecium ATCC 700221 after 16 to 18 hrs by broth microdilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Halogenated quinolines bearing polar functionality at the 2-position: Identification of new antibacterial agents with enhanced activity against Staphylococcus epidermidis. |
| AID278931 | Antibacterial activity against Enterococcus faecalis ATCC 51922 by time kill experiments | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | In vitro antibacterial activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. |
| AID1367594 | Antibacterial activity against gram-negative Escherichia coli MG1655 expressing AcrAB-TolC efflux pump deletion mutant by CLSI broth microdilution method | 2017 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23 | Compound design guidelines for evading the efflux and permeation barriers of Escherichia coli with the oxazolidinone class of antibacterials: Test case for a general approach to improving whole cell Gram-negative activity. |
| AID1390477 | Antibacterial activity against Enterococcus faecalis ATCC 51299 | 2018 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 28, Issue:7 | Design, synthesis and biological evaluation of spiropyrimidinetriones oxazolidinone derivatives as antibacterial agents. |
| AID283387 | Effect on mitochondrial DNA level in PBMCs from patient on a long-term schedule of the drug with hyperlactatemia relative to control | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Reversible inhibition of mitochondrial protein synthesis during linezolid-related hyperlactatemia. |
| AID533936 | Antimicrobial activity against linezolid-resistant Staphylococcus aureus 131-6952X harboring plasmid borne cfr gene by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains. |
| AID326286 | Antibacterial activity against methicillin-resistant Staphylococcus aureus 4875 at 4 hrs daily exposure for 1 day by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Comparative activities of daptomycin, linezolid, and tigecycline against catheter-related methicillin-resistant Staphylococcus bacteremic isolates embedded in biofilm. |
| AID323787 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus Xen29 infected neutropenic CD1 mouse assessed as mouse survival at 50 mg/kg, sc after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Rapid bactericidal activity of daptomycin against methicillin-resistant and methicillin-susceptible Staphylococcus aureus peritonitis in mice as measured with bioluminescent bacteria. |
| AID528723 | Antibacterial activity against Streptococcus constellatus clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID1557278 | Antitubercular activity against Mycobacterium tuberculosis XDR | 2019 | MedChemComm, Aug-01, Volume: 10, Issue:8 | Drug-resistance in |
| AID458458 | Antimicrobial activity against Escherichia coli ATCC 25922 at 2 mM after overnight incubation by agar diffusion method | 2010 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 20, Issue:3 | Syntheses and antibacterial activity studies of new oxazolidinones from nitroso Diels-Alder chemistry. |
| AID528727 | Antibacterial activity against Streptococcus agalactiae group B clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID545809 | Antimicrobial activity against methicillin-sensitive Staphylococcus aureus ATCC 29213 assessed as inhibition of biofilm formation after 24 hrs by serial dilution method in presence of 0.002% polysorbate 80 | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Oritavancin kills stationary-phase and biofilm Staphylococcus aureus cells in vitro. |
| AID390333 | Antimicrobial activity against Haemophilus parainfluenzae 2319 | 2008 | Journal of natural products, Dec, Volume: 71, Issue:12 | Citreamicins with potent gram-positive activity. |
| AID528839 | Antimicrobial activity against vancomycin-resistant Enterococcus sp. isolated from ICU patient blood assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID1660515 | Antibacterial activity against Bacillus cereus ATCC 14579 after 16 hrs by CLSI-based broth microdilution method | 2020 | Journal of natural products, 06-26, Volume: 83, Issue:6 | Synthesis of the Cyanobacterial Antibiotics Anaephenes A and B. |
| AID511383 | Antibacterial activity against vancomycin resistant Enterococcus faecalis by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Comparative in vitro activities of nemonoxacin (TG-873870), a novel nonfluorinated quinolone, and other quinolones against clinical isolates. |
| AID523028 | Antimicrobial activity against Staphylococcus aureus by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative in vitro antimicrobial activities of torezolid (TR-700), the active moiety of a new oxazolidinone, torezolid phosphate (TR-701), determination of tentative disk diffusion interpretive criteria, and quality control ranges. |
| AID318353 | Antibacterial activity against methicillin-resistant Staphylococcus aureus | 2007 | Proceedings of the National Academy of Sciences of the United States of America, May-01, Volume: 104, Issue:18 | Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties. |
| AID1563586 | Inhibition of FabB/FabF in methicillin-resistant Staphylococcus aureus assessed as antibacterial activity after 16 hrs by agar dilution method | 2019 | Journal of medicinal chemistry, 07-25, Volume: 62, Issue:14 | Late-Stage Functionalization of Platensimycin Leading to Multiple Analogues with Improved Antibacterial Activity in Vitro and in Vivo. |
| AID1853479 | Bactericidal activity against persister methicillin-resistant Staphylococcus aureus ATCC 33592 assessed as reduction in colony forming unit at 4 x MIC incubated for 18 to 24 hrs by Time-kill analysis | 2021 | RSC medicinal chemistry, Nov-17, Volume: 12, Issue:11 | SF |
| AID530122 | Antimicrobial activity against hospital acquired methicillin-resistant Staphylococcus aureus 149 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Pharmacodynamic characterization of ceftobiprole in experimental pneumonia caused by phenotypically diverse Staphylococcus aureus strains. |
| AID572020 | Antibacterial activity against Prevotella melaninogenica by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID1139113 | Antimicrobial activity against Streptococcus pneumoniae infected in rat lung infection model assessed as log reduction of bacterial density at 30 mg/kg, po | 2014 | Bioorganic & medicinal chemistry letters, May-01, Volume: 24, Issue:9 | Successful application of serum shift prediction models to the design of dual targeting inhibitors of bacterial gyrase B and topoisomerase IV with improved in vivo efficacy. |
| AID207424 | In vitro antibacterial activity against Staphylococcus aureus ATCC 49951 (S. a. 213) | 2002 | Journal of medicinal chemistry, Aug-29, Volume: 45, Issue:18 | Synthesis of conformationally constrained analogues of linezolid: structure-activity relationship (SAR) studies on selected novel tricyclic oxazolidinones. |
| AID574952 | Antimicrobial activity against Streptococcus pneumoniae serotype 11A by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID1519050 | Stability in human liver microsomes assessed as half life at 1.5 uM preincubated for 5 mins with NADPH and measured after 45 mins by LC/MS analysis | 2020 | European journal of medicinal chemistry, Jan-01, Volume: 185 | Optimization of biaryloxazolidinone as promising antibacterial agents against antibiotic-susceptible and antibiotic-resistant gram-positive bacteria. |
| AID278916 | Antibacterial activity against linezolid-resistant Enterococcus faecalis | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | In vitro antibacterial activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. |
| AID555315 | Antibacterial activity against methicillin-susceptible, vancomycin-intermediate Staphylococcus aureus 505 by broth macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Antistaphylococcal activity of dihydrophthalazine antifolates, a family of novel antibacterial drugs. |
| AID293837 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus 209P | 2007 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6 | A new class of anti-MRSA and anti-VRE agents: preparation and antibacterial activities of indole-containing compounds. |
| AID528707 | Antibacterial activity against Streptococcus pyogenes group A clinical isolate assessed as susceptibility level by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID560583 | Bactericidal activity against vancomycin-resistant Enterococcus faecalis 1058946 expressing vanA gene assessed as change in bacterial count at 4 ug/ml by time-kill assay | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Impact of human serum albumin on oritavancin in vitro activity against enterococci. |
| AID520231 | Antimicrobial activity against Streptococcus pneumoniae 02J1258 | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID541540 | Antimicrobial activity against vancomycin-resistant Enterococcus faecium clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID572018 | Antibacterial activity against Prevotella nigrescens by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID1409845 | Antibacterial activity against vancomycin-intermediate Staphylococcus aureus Mu50 infected in BALB/c mouse assessed as reduction of bacterial burden in heart at 0.4 mg, ip bid for 3.5 days administered 6 hrs post bacterial infection measured 84 hrs post i | 2018 | ACS medicinal chemistry letters, Mar-08, Volume: 9, Issue:3 | Novel Staphyloxanthin Inhibitors with Improved Potency against Multidrug Resistant |
| AID428276 | Antituberculosis activity against Mycobacterium tuberculosis by bactec MGIT 960 method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro-selected linezolid-resistant Mycobacterium tuberculosis mutants. |
| AID424765 | Antibacterial activity against vancomycin, macrolide-resistant, linezolid-sensitive Enterococcus faecalis CL5246 after 20 hrs by twofold serial broth dilution method | 2009 | Journal of natural products, May-22, Volume: 72, Issue:5 | Thiazomycins, thiazolyl peptide antibiotics from Amycolatopsis fastidiosa. |
| AID533940 | Antimicrobial activity against linezolid-resistant Enterococcus faecalis 411 harboring G2576U mutation in peptidyl transferase centre by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains. |
| AID370013 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus Smith infected in C3H mouse assessed as reduction in log number of CFU at 6.25 mg/kg/day, po administered within 15 mins of infection measured after 48 hrs by organ burden assay | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vivo efficacy of a novel oxazolidinone compound in two mouse models of infection. |
| AID1434681 | Anti-bacterial activity against methicillin-resistant Staphylococcus aureus CCARM 3634 by 2-fold microtiter broth dilution method | 2017 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 27, Issue:3 | Cadiolides J-M, antibacterial polyphenyl butenolides from the Korean tunicate Pseudodistoma antinboja. |
| AID66098 | Inhibitory activity against Enterococcus faecium | 1996 | Journal of medicinal chemistry, Sep-27, Volume: 39, Issue:20 | New directions in antibacterial research. |
| AID1180585 | Ratio of MIC for 2 times drug resistance selected Staphylococcus aureus ARC2381-2F to MIC for Staphylococcus aureus ARC2381 | 2014 | Journal of medicinal chemistry, Jul-24, Volume: 57, Issue:14 | Optimization of pyrrolamide topoisomerase II inhibitors toward identification of an antibacterial clinical candidate (AZD5099). |
| AID561088 | Antibacterial activity against Haemophilus influenzae by CLSI M7-A7 broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | In vitro activity of TR-700, the active ingredient of the antibacterial prodrug TR-701, a novel oxazolidinone antibacterial agent. |
| AID753130 | Antitubercular activity against Mycobacterium tuberculosis XDR-1 assessed as growth inhibition after 2 to 3 weeks by broth microdilution method | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | Anti-tubercular agents. Part 7: a new class of diarylpyrrole-oxazolidinone conjugates as antimycobacterial agents. |
| AID1451758 | Antibacterial activity against Staphylococcus aureus Newman infected in BALB/c mouse assessed as reduction of bacterial burden in liver at 0.1 mg, ip bid for 4.5 days pretreated 24 hrs prior to bacterial infection measured 108 hrs post infection relative | 2017 | Journal of medicinal chemistry, 10-12, Volume: 60, Issue:19 | Novel Inhibitors of Staphyloxanthin Virulence Factor in Comparison with Linezolid and Vancomycin versus Methicillin-Resistant, Linezolid-Resistant, and Vancomycin-Intermediate Staphylococcus aureus Infections in Vivo. |
| AID562390 | Antimicrobial activity against oxacillin-resistant Staphylococcus haemolyticus clinical isolates assessed as percent susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID561258 | Antibacterial activity against Streptococcus agalactiae assessed as susceptible isolates by CLSI M100-S17 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | AFN-1252, a FabI inhibitor, demonstrates a Staphylococcus-specific spectrum of activity. |
| AID1304843 | Antibiofilm activity against methicillin-resistant Enterococcus faecium ATCC 700221 assessed as biofilm eradication incubated for 24 hrs by CBD assay | 2016 | Journal of medicinal chemistry, 04-28, Volume: 59, Issue:8 | Structure-Activity Relationships of a Diverse Class of Halogenated Phenazines That Targets Persistent, Antibiotic-Tolerant Bacterial Biofilms and Mycobacterium tuberculosis. |
| AID1609279 | Bactericidal activity against methicilline-sensitive Staphylococcus aureus ATCC 6538 incubated for 18 to 20 hrs followed by replating on tryptic soy agar plate and further incubated for 18 to 24 hrs by CLSI-based broth microdilution assay | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Phenylthiazoles with nitrogenous side chain: An approach to overcome molecular obesity. |
| AID278571 | Antimicrobial activity against vancomycin-resistant Enterococcus faecalis ATCC 51299 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | In vitro activities of the lipopeptides palmitoyl (Pal)-Lys-Lys-NH(2) and Pal-Lys-Lys alone and in combination with antimicrobial agents against multiresistant gram-positive cocci. |
| AID541516 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID572004 | Antibacterial activity against Bacteroides ovatus by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID528970 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus isolated from ICU patient wound assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID1395711 | Bactericidal activity against vancomycin-resistant Staphylococcus aureus VRS12 incubated fo 18 hrs followed by re-plating on tryptic soy agar plates at 37 degC for 18 hrs by broth microdilution assay | 2018 | European journal of medicinal chemistry, May-10, Volume: 151 | Phenylthiazoles with tert-Butyl side chain: Metabolically stable with anti-biofilm activity. |
| AID523048 | Antimicrobial activity against beta-lactamase negative Haemophilus influenzae by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative in vitro antimicrobial activities of torezolid (TR-700), the active moiety of a new oxazolidinone, torezolid phosphate (TR-701), determination of tentative disk diffusion interpretive criteria, and quality control ranges. |
| AID548531 | Antimicrobial activity against Vancomycin-susceptible Enterococcus faecium by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Activities of dalbavancin against a worldwide collection of 81,673 gram-positive bacterial isolates. |
| AID373833 | Antimicrobial activity against panton-valentine leukocidin-positive community-acquired methicillin-resistant Staphylococcus aureus 490 after 50 passages with vancomycin measured after 10 antibiotic-free subculture by multi-step resistance selection techni | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID524950 | Antibacterial activity against methicillin-susceptible coagulase-negative Staphylococcus sciuri clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Comparative surveillance study of telavancin activity against recently collected gram-positive clinical isolates from across the United States. |
| AID671564 | Antibacterial activity against Streptococcus pyogenes | 2012 | Journal of medicinal chemistry, Jan-26, Volume: 55, Issue:2 | Fluorocyclines. 2. Optimization of the C-9 side-chain for antibacterial activity and oral efficacy. |
| AID528728 | Antibacterial activity against Streptococcus pyogenes group A clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID523836 | Ratio of vancomycin MIC50 to compound MIC50 for linezolid-susceptible Staphylococcus aureus | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative activities of TR-700 (torezolid) against staphylococcal blood isolates collected in Spain. |
| AID541094 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 infected in Albino guiena pig assessed as cure rate at 25 mg/kg measured on day 10 postinfection | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Linezolid alone or combined with rifampin against methicillin-resistant Staphylococcus aureus in experimental foreign-body infection. |
| AID1154474 | Antibacterial activity against of methicillin-sensitive Staphylococcus aureus ATCC 19636 infected in iv dosed mouse administered 1 hr after infection measured after 48 hrs | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | Design, synthesis, and structure-activity relationship studies of novel thioether pleuromutilin derivatives as potent antibacterial agents. |
| AID571826 | Antibacterial activity against Coriobacteriumecies by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID1151709 | Myelosuppression activity against human CD34-positive blood stem/progenitor cells assessed as growth inhibition after 9 to 10 days by CellTiter-Glo luminescent assay | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID1877888 | Antibacterial activity against Enterococcus faecium DSM-20477 assessed as bacterial growth inhibition | 2022 | Bioorganic & medicinal chemistry letters, 03-01, Volume: 59 | Novel 2,4-disubstituted quinazoline analogs as antibacterial agents with improved cytotoxicity profile: Modification of the benzenoid part. |
| AID558487 | Antimicrobial activity against vancomycin-resistant Staphylococcus aureus 510 measured on day 10 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID559360 | Antimicrobial activity against compound-susceptible Coxiella burnetii Nine-Mile obtained from patient with acute Q fever infected in african green monkey Vero cells after 24 hrs by shell vial assay | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Bacteriostatic and bactericidal activities of tigecycline against Coxiella burnetii and comparison with those of six other antibiotics. |
| AID573146 | Antibacterial activity against penicillin-nonsusceptible Streptococcus viridans by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID522917 | Antibacterial activity against hospital-acquired methicillin-resistant Staphylococcus aureus isolate 1867 after 24 hrs by modified broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Antistaphylococcal activity of ACHN-490 tested alone and in combination with other agents by time-kill assay. |
| AID571790 | Antibacterial activity against Clostridium clostridioforme by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID207423 | In vitro antibacterial activity against methicillin resistant Staphylococcus aureus ATCC 33591 (S. a. 019) | 2002 | Journal of medicinal chemistry, Aug-29, Volume: 45, Issue:18 | Synthesis of conformationally constrained analogues of linezolid: structure-activity relationship (SAR) studies on selected novel tricyclic oxazolidinones. |
| AID206629 | Antibacterial activity was determined against clinically isolated Levofloxacin-methicillin resistant Staphylococcus aureus (LVFX-r MRSA) strains (74 strains) | 2003 | Journal of medicinal chemistry, Mar-13, Volume: 46, Issue:6 | Synthesis and structure-activity relationships of 5-amino-6-fluoro-1-[(1R,2S)-2-fluorocyclopropan-1-yl]-8-methylquinolonecarboxylic acid antibacterials having fluorinated 7-[(3R)-3-(1-aminocyclopropan-1-yl)pyrrolidin-1-yl] substituents. |
| AID585165 | Antibacterial activity against Mycobacterium smegmatis harboring 23S rRNA C2612A mutant after 24 generation times | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Mutations in 23S rRNA at the peptidyl transferase center and their relationship to linezolid binding and cross-resistance. |
| AID541808 | Antimicrobial activity against Enterococcus durans clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID1760591 | Antibacterial activity against vancomycin resistant Enterococcus faecalis 51575 assessed as inhibition of bacterial growth measured after 24 hrs | 2021 | European journal of medicinal chemistry, Feb-05, Volume: 211 | Installation of an aryl boronic acid function into the external section of N-aryl-oxazolidinones: Synthesis and antimicrobial evaluation. |
| AID304007 | Effect on hematology in Sprague-Dawley rat assessed as decrease in reticulocytes at 200 mg/kg/day after 14 days | 2007 | Journal of medicinal chemistry, Nov-29, Volume: 50, Issue:24 | Antibacterial oxazolidinones possessing a novel C-5 side chain. (5R)-trans-3-[3-Fluoro-4- (1-oxotetrahydrothiopyran-4-yl)phenyl]-2- oxooxazolidine-5-carboxylic acid amide (PF-00422602), a new lead compound. |
| AID511304 | Antibacterial activity against ciprofloxacin and methicillin resistant Staphylococcus aureus by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Comparative in vitro activities of nemonoxacin (TG-873870), a novel nonfluorinated quinolone, and other quinolones against clinical isolates. |
| AID541546 | Antimicrobial activity against penicillin-susceptible Streptococcus pneumoniae clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID275469 | Antibacterial activity against Staphylococcus aureus ATCC 33591 infected in CD1 mouse at 20 mg/kg, sc | 2007 | Journal of medicinal chemistry, Jan-25, Volume: 50, Issue:2 | Isothiazoloquinolones with enhanced antistaphylococcal activities against multidrug-resistant strains: effects of structural modifications at the 6-, 7-, and 8-positions. |
| AID1539453 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis ATCC 51299 clinical isolates after 18 to 20 hrs in aerobic condition by CLSI-based broth microdilution assay | |||
| AID775548 | Antibacterial activity against Staphylococcus aureus SR20549 clinical isolate assessed as growth inhibition by broth microdilution method | 2013 | European journal of medicinal chemistry, Nov, Volume: 69 | Synthesis and in vitro/in vivo antibacterial activity of oxazolidinones having thiocarbamate at C-5 on the A-ring and an amide- or urea-substituted [1,2,5]triazepane or [1,2,5]oxadiazepane as the C-ring. |
| AID1759684 | Inhibition of protein synthesis in Staphylococcus aureus ATCC 29213 at 8 times MIC measured by liquid scintillation counter | 2021 | European journal of medicinal chemistry, Jul-05, Volume: 219 | 4-4-(Anilinomethyl)-3-[4-(trifluoromethyl)phenyl]-1H-pyrazol-1-ylbenzoic acid derivatives as potent anti-gram-positive bacterial agents. |
| AID1180570 | Antimicrobial activity against 2 times drug resistance selected Staphylococcus aureus ARC516-1F by broth microdilution/CLSI method | 2014 | Journal of medicinal chemistry, Jul-24, Volume: 57, Issue:14 | Optimization of pyrrolamide topoisomerase II inhibitors toward identification of an antibacterial clinical candidate (AZD5099). |
| AID542686 | fAUC (24 hrs) in Bacillus anthracis infected in vitro hollow fiber PK/PD model at simulated dose of 700 mg administered every 24 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID745404 | Antibacterial activity against Enterococcus faecalis SR1004 clinical isolate assessed as growth inhibition by CLSI broth microdilution method | 2013 | European journal of medicinal chemistry, May, Volume: 63 | Antibacterial oxazolidinone analogues having a N-hydroxyacetyl-substituted seven-membered [1,2,5]triazepane or [1,2,5]oxadiazepane C-ring unit. |
| AID548746 | Antimicrobial activity against viridans group Streptococcus assessed as percent susceptible isolate by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Activities of dalbavancin against a worldwide collection of 81,673 gram-positive bacterial isolates. |
| AID558085 | Antimicrobial activity against Mycoplasma fermentans isolated from human by two fold serial dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Comparative in vitro susceptibilities of human mycoplasmas and ureaplasmas to a new investigational ketolide, CEM-101. |
| AID1167738 | Antimicrobial activity against methicillin-sensitive Staphylococcus aureus by broth microdilution method in presence of 50% human serum | 2014 | Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21 | Novel DNA gyrase inhibiting spiropyrimidinetriones with a benzisoxazole scaffold: SAR and in vivo characterization. |
| AID1862423 | Antibacterial activity against methicillin-resistant Staphylococcus aureus USA 300 assessed as reduction in visible bacterial growth incubated for 18 to 20 hrs by CLSI based broth microdilution analysis | 2022 | European journal of medicinal chemistry, Oct-05, Volume: 240 | Membrane acting Povarov-Doebner derived compounds potently disperse preformed multidrug resistant Gram-positive bacterial biofilms. |
| AID585157 | Antibacterial activity against Mycobacterium smegmatis harboring 23S rRNA A2058G mutant after 24 generation times | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Mutations in 23S rRNA at the peptidyl transferase center and their relationship to linezolid binding and cross-resistance. |
| AID283157 | Antimicrobial susceptibility of Staphylococcus lugdunensis IDRL2414 biofilms after 24 hrs assessed as bacterial regrowth | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | In vitro effects of antimicrobial agents on planktonic and biofilm forms of Staphylococcus lugdunensis clinical isolates. |
| AID572003 | Antibacterial activity against Bacteroides fragilis by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID1271211 | Metabolic stability in rat liver microsomes after 30 mins by LC-MS/MS analysis | 2015 | ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11 | Design, Synthesis, and Identification of Silicon Incorporated Oxazolidinone Antibiotics with Improved Brain Exposure. |
| AID1474257 | Toxicity in Caenorhabditis elegans AU37 assessed as worm survival at 20 ug/ml after 24 hrs by microscopic analysis | 2017 | Journal of medicinal chemistry, 03-23, Volume: 60, Issue:6 | Phenylthiazole Antibacterial Agents Targeting Cell Wall Synthesis Exhibit Potent Activity in Vitro and in Vivo against Vancomycin-Resistant Enterococci. |
| AID1400045 | Bactericidal activity against Staphylococcus aureus BAA 44 incubated for 24 hrs under aerobic condition by MABA | 2018 | Bioorganic & medicinal chemistry, 09-15, Volume: 26, Issue:17 | An antimycobacterial pleuromutilin analogue effective against dormant bacilli. |
| AID311476 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 after 14 to 16 hrs by serial micro-broth dilution method | 2007 | Journal of natural products, Sep, Volume: 70, Issue:9 | Lipoxazolidinones A, B, and C: antibacterial 4-oxazolidinones from a marine actinomycete isolated from a Guam marine sediment. |
| AID370034 | Antibacterial activity against methicillin-resistant Staphylococcus aureus COL infected in po dosed DBA/2 mouse localized infection model assessed as log reduction in CFU per gram of thigh at 10 mg/kg, po administered 2 hrs postinfection thrice daily for | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vivo efficacy of a novel oxazolidinone compound in two mouse models of infection. |
| AID558705 | Antimicrobial activity against vancomycin-resistant Staphylococcus aureus 510 measured on day 35 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID1167736 | Antimicrobial activity against Escherichia coli by broth microdilution method | 2014 | Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21 | Novel DNA gyrase inhibiting spiropyrimidinetriones with a benzisoxazole scaffold: SAR and in vivo characterization. |
| AID285544 | Cmax in mouse at 50 mg/kg, sc | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | In vitro and in vivo antibacterial activities of heteroaryl isothiazolones against resistant gram-positive pathogens. |
| AID387450 | Antibacterial activity against linezolid-resistant Staphylococcus aureus DRCC 564 | 2008 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 18, Issue:18 | Novel and potent oxazolidinone antibacterials featuring 3-indolylglyoxamide substituents. |
| AID573869 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus ATCC 13709 infected in sc dosed Swiss Webster mouse administered at 1 to 3 hrs post infection measured after 3 days | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | In vivo activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. |
| AID208611 | Antibacterial activity was determined against clinically isolated penicillin resistant Streptococcus pneumoniae (PRSP) strains (50 strains) | 2003 | Journal of medicinal chemistry, Mar-13, Volume: 46, Issue:6 | Synthesis and structure-activity relationships of 5-amino-6-fluoro-1-[(1R,2S)-2-fluorocyclopropan-1-yl]-8-methylquinolonecarboxylic acid antibacterials having fluorinated 7-[(3R)-3-(1-aminocyclopropan-1-yl)pyrrolidin-1-yl] substituents. |
| AID541091 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 during logarithmic growth phase by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Linezolid alone or combined with rifampin against methicillin-resistant Staphylococcus aureus in experimental foreign-body infection. |
| AID125077 | In vitro antibacterial activity against Moraxella catarrhalis 30607 | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | The synthesis and antibacterial activity of 1,3,4-thiadiazole phenyl oxazolidinone analogues. |
| AID1689205 | Antibacterial activity against methicillin resistant Staphylococcus aureus subsp. aureus USA300 assessed as reduction in bacterial growth by CLSI based broth microdilution method | 2020 | European journal of medicinal chemistry, Mar-01, Volume: 189 | Oxadiazolylthiazoles as novel and selective antifungal agents. |
| AID528725 | Antibacterial activity against Streptococcus intermedius clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID1578417 | Antimicrobial activity against vancomycin-resistant Staphylococcus aureus 10 by broth liquid microdilution method | 2020 | European journal of medicinal chemistry, Jan-01, Volume: 185 | Modifying the lipophilic part of phenylthiazole antibiotics to control their drug-likeness. |
| AID1862415 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 33592 assessed as reduction in visible bacterial growth incubated for 18 to 20 hrs by CLSI based broth microdilution analysis | 2022 | European journal of medicinal chemistry, Oct-05, Volume: 240 | Membrane acting Povarov-Doebner derived compounds potently disperse preformed multidrug resistant Gram-positive bacterial biofilms. |
| AID326296 | Antibacterial activity against methicillin-resistant Staphylococcus aureus 4875 at 4 hrs daily exposure for 5 days by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Comparative activities of daptomycin, linezolid, and tigecycline against catheter-related methicillin-resistant Staphylococcus bacteremic isolates embedded in biofilm. |
| AID540213 | Half life in human after iv administration | 2008 | Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7 | Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. |
| AID1446761 | Bactericidal activity against vancomycin-resistant Staphylococcus aureus VRSA4 after 18 hrs by broth microdilution method | 2017 | European journal of medicinal chemistry, Apr-21, Volume: 130 | Diphenylurea derivatives for combating methicillin- and vancomycin-resistant Staphylococcus aureus. |
| AID1553377 | Stability in gastric pH assessed as compound remaining after 24 hrs relative to control | 2019 | Bioorganic & medicinal chemistry letters, 09-15, Volume: 29, Issue:18 | Incorporation of a chiral gem-disubstituted nitrogen heterocycle yields an oxazolidinone antibiotic with reduced mitochondrial toxicity. |
| AID349309 | Antibacterial activity against methicillin-resistant Staphylococcus aureus clinical isolate after 18 hrs by agar dilution method | 2008 | European journal of medicinal chemistry, May, Volume: 43, Issue:5 | Synthesis and structure-antibacterial activity of triazolyl oxazolidinones containing long chain acyl moiety. |
| AID1584842 | Antibacterial activity against community-acquired methicillin and erythromycin resistant Staphylococcus aureus SA 325 after 18 to 24 hrs by microdilution assay | 2018 | European journal of medicinal chemistry, Nov-05, Volume: 159 | 1-(2-Hydroxybenzoyl)-thiosemicarbazides are promising antimicrobial agents targeting d-alanine-d-alanine ligase in bacterio. |
| AID285116 | Antimicrobial activity against viridans group Streptococcus oralis at 1 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID519990 | Antimicrobial activity against vancomycin-susceptible Enterococcus faecalis nosocomial isolate | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID555294 | Antibacterial activity against Tmp-susceptible Staphylococcus aureus by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Antistaphylococcal activity of dihydrophthalazine antifolates, a family of novel antibacterial drugs. |
| AID577127 | Terminal half-life in two-compartment pharmacokinetic/pharmacodynamic model at 200 mg, bid administered as 0.5 hr infusion over 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID383564 | Antibacterial activity against Staphylococcus aureus ATCC 29213 by broth microdilution technique | 2008 | European journal of medicinal chemistry, Apr, Volume: 43, Issue:4 | Synthesis and in vitro antibacterial activities of novel oxazolidinones. |
| AID69194 | Minimum inhibitory concentration (MIC) against Escherichia coli OC 2605 | 2004 | Bioorganic & medicinal chemistry letters, Jun-21, Volume: 14, Issue:12 | The synthesis and antimicrobial evaluation of a new series of isoxazolinyl oxazolidinones. |
| AID1139111 | Clearance in rat at 2.8 to 9.5 mg/kg, iv | 2014 | Bioorganic & medicinal chemistry letters, May-01, Volume: 24, Issue:9 | Successful application of serum shift prediction models to the design of dual targeting inhibitors of bacterial gyrase B and topoisomerase IV with improved in vivo efficacy. |
| AID524682 | Antibacterial activity against glycopeptide-intermediate Staphylococcus aureus clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro antibacterial activity of CE-156811, a novel analog derived from hygromycin A. |
| AID604294 | Antibacterial activity against Bacillus subtilis BD54 after 16 to 24 hrs by twofold serial dilution method | 2011 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 21, Issue:14 | 7-Alkyl-N(2)-substituted-3-deazaguanines. Synthesis, DNA polymerase III inhibition and antibacterial activity. |
| AID1361097 | Bacteriostatic activity against methicillin-resistant Staphylococcus aureus NRS119 clinical isolate after 20 hrs by broth microdilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | N-(1,3,4-oxadiazol-2-yl)benzamide analogs, bacteriostatic agents against methicillin- and vancomycin-resistant bacteria. |
| AID1688278 | In vivo antibacterial activity against methicillin resistant Staphylococcus aureus clinical isolate 15-1 infected in kunming mouse assessed as animal survival rate at 3 mg/kg, po administered 6 hrs prior to bacterial infection and at 0 and 6 hrs post infe | 2020 | European journal of medicinal chemistry, Feb-15, Volume: 188 | N-thiadiazole-4-hydroxy-2-quinolone-3-carboxamides bearing heteroaromatic rings as novel antibacterial agents: Design, synthesis, biological evaluation and target identification. |
| AID572556 | Antibacterial activity against multidrug-resistant Mycobacterium tuberculosis by agar proportion method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | In vitro activities of linezolid against clinical isolates of Mycobacterium tuberculosis complex isolated in Taiwan over 10 years. |
| AID318360 | Antibacterial activity against wild type Escherichia coli | 2007 | Proceedings of the National Academy of Sciences of the United States of America, May-01, Volume: 104, Issue:18 | Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties. |
| AID1677803 | Antibacterial activity against Escherichia coli ATCC25922 incubated for 24 hrs by CLSI-based broth microdilution method | 2020 | Bioorganic & medicinal chemistry, 11-01, Volume: 28, Issue:21 | Design, synthesis of novel 4,5-dihydroisoxazole-containing benzamide derivatives as highly potent FtsZ inhibitors capable of killing a variety of MDR Staphylococcus aureus. |
| AID1056364 | Antibacterial activity against Staphylococcus aureus SR20549 clinical isolate assessed as parasite growth inhibition by CLSI broth microdilution method | 2013 | ACS medicinal chemistry letters, Nov-14, Volume: 4, Issue:11 | Potent oxazolidinone antibacterials with heteroaromatic C-ring substructure. |
| AID1361109 | Bactericidal activity against methicillin-resistant Staphylococcus aureus USA500 NRS385 clinical isolate preincubated for 20 hrs followed by TSA plating and measured after 18 hrs | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | N-(1,3,4-oxadiazol-2-yl)benzamide analogs, bacteriostatic agents against methicillin- and vancomycin-resistant bacteria. |
| AID285020 | Antimicrobial activity against Listeria monocytogenes at 0.12 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID1594375 | Antibacterial activity against Escherichia coli BW25113 after 18 to 24 hrs in absence of colistin by broth microdilution method | 2019 | Bioorganic & medicinal chemistry, 05-01, Volume: 27, Issue:9 | Second-generation aryl isonitrile compounds targeting multidrug-resistant Staphylococcus aureus. |
| AID1151758 | Antibacterial activity against vancomycin-sensitive/high-level gentamycin-resistant Enterococcus faecalis isolate HH22 | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID297128 | Antibacterial activity against Staphylococcus aureus Smith after 18 hrs by agar plate dilution method | 2007 | Journal of medicinal chemistry, Aug-23, Volume: 50, Issue:17 | Discovery of 1,4-dihydroxy-2-naphthoate [corrected] prenyltransferase inhibitors: new drug leads for multidrug-resistant gram-positive pathogens. |
| AID524964 | Antibacterial activity against methicillin-resistant coagulase-negative Staphylococcus xylosus clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Comparative surveillance study of telavancin activity against recently collected gram-positive clinical isolates from across the United States. |
| AID717875 | Antibacterial activity against methicillin-resistant Staphylococcus aureus OM584 by two-fold liquid microdilution method | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24 | Riccardin C derivatives as anti-MRSA agents: structure-activity relationship of a series of hydroxylated bis(bibenzyl)s. |
| AID285029 | Antimicrobial activity against Micrococcus luteus at 1 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID558513 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus 525 measured on day 25 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID562587 | Antimicrobial activity against Enterococcus faecium expressing VanB gene clinical isolates assessed as resistant isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID637971 | Antibacterial activity against Streptococcus pneumoniae expressing PenR gene after overnight incubation by twofold broth dilution technique | 2012 | Bioorganic & medicinal chemistry, Jan-01, Volume: 20, Issue:1 | Efficient microwave-assisted synthesis, antibacterial activity and high fluorescence of 5 benzimidazolyl-2'-deoxyuridines. |
| AID1680075 | Antibacterial activity against Staphylococcus aureus ATCC 29213 assessed as reduction in bacterial measured after 20 passages by CLSI-based broth microdilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Synthesis and antibacterial bioactivities of cationic deacetyl linezolid amphiphiles. |
| AID285140 | Antimicrobial activity against viridans group Streptococcus vestibularis at 1 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID524948 | Antibacterial activity against methicillin-susceptible coagulase-negative Staphylococcus hominis clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Comparative surveillance study of telavancin activity against recently collected gram-positive clinical isolates from across the United States. |
| AID1243929 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus USA500 assessed as reduction in bacterial growth incubated for 18 to 20 hrs at 37 degC by broth microdilution method | 2015 | European journal of medicinal chemistry, Aug-28, Volume: 101 | Discovery and characterization of aryl isonitriles as a new class of compounds versus methicillin- and vancomycin-resistant Staphylococcus aureus. |
| AID560584 | Bactericidal activity against vancomycin-resistant Enterococcus faecium 1119175 expressing vanB gene assessed as change in bacterial count at 4 ug/ml by time-kill assay | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Impact of human serum albumin on oritavancin in vitro activity against enterococci. |
| AID1446754 | Antibacterial activity against methicillin-resistant Staphylococcus aureus USA100 NRS382 clinical isolate after 20 hrs by broth microdilution method | 2017 | European journal of medicinal chemistry, Apr-21, Volume: 130 | Diphenylurea derivatives for combating methicillin- and vancomycin-resistant Staphylococcus aureus. |
| AID295160 | Antibacterial activity against methicillin-resistant Staphylococcus aureus BAA-42 infected po dosed KunMing mouse | 2007 | European journal of medicinal chemistry, Aug, Volume: 42, Issue:8 | Synthesis and antibacterial activity of oxazolidinones containing triazolyl group. |
| AID285099 | Antimicrobial activity against viridans group Streptococcus intermedius at 2 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID533985 | Bacteriostatic activity against linezolid-susceptible Staphylococcus aureus NRS18 infected in THP1 cells after 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Cellular pharmacodynamics of the novel biaryloxazolidinone radezolid: studies with infected phagocytic and nonphagocytic cells, using Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Legionella pneumophila. |
| AID522886 | Antibacterial activity against vancomycin-hetero-intermediate Staphylococcus aureus isolate 618 after 24 hrs by modified broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Antistaphylococcal activity of ACHN-490 tested alone and in combination with other agents by time-kill assay. |
| AID531638 | Selectivity ratio of IC50 for rabbit reticulocyte 50S ribosomal subunit to IC50 for Staphylococcus aureus ATCC 29213 50S ribosomal subunit | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | R chi-01, a new family of oxazolidinones that overcome ribosome-based linezolid resistance. |
| AID583196 | Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus isolate NJ992 after 24 hrs by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | In vitro activity of the new multivalent glycopeptide-cephalosporin antibiotic TD-1792 against vancomycin-nonsusceptible Staphylococcus isolates. |
| AID1853451 | Antibacterial activity against methicillin-resistant Staphylococcus aureus USA300 assessed as bacterial growth inhibition incubated for 18 to 20 hrs by CLSI based broth microdilution assay | 2021 | RSC medicinal chemistry, Nov-17, Volume: 12, Issue:11 | SF |
| AID278573 | Antimicrobial activity against Rhodococcus equi ATCC 6939 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | In vitro activities of the lipopeptides palmitoyl (Pal)-Lys-Lys-NH(2) and Pal-Lys-Lys alone and in combination with antimicrobial agents against multiresistant gram-positive cocci. |
| AID116078 | Minimum inhibitory concentration in mice against antimicrobial activity in vancomycin-resistant Enterococcus faecalis (VREF 29212). | 2004 | Bioorganic & medicinal chemistry letters, May-03, Volume: 14, Issue:9 | DNA binding ligands with in vivo efficacy in murine models of bacterial infection: optimization of internal aromatic amino acids. |
| AID581029 | Inhibition of lipid synthesis in Staphylococcus epidermidis ATCC 23760 assessed as incorporation of [14C]acetate at 2 ug/ml after 60 mins by liquid scintillation counter | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Mode of action of Ranbezolid against staphylococci and structural modeling studies of its interaction with ribosomes. |
| AID1723493 | Antibacterial activity against Enterococcus faecium NR-31903 incubated for 18 to 20 hrs under aerobic condition by CLSI protocol based broth microdilution assay | |||
| AID523812 | Antimicrobial activity against linezolid-susceptible coagulase-negative Staphylococcus assessed as inhibition of microbial growth at 2 ug/ml by CLSI method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative activities of TR-700 (torezolid) against staphylococcal blood isolates collected in Spain. |
| AID1594378 | Antibacterial activity against AcrAB-TolC deficient Escherichia coli JW25113 after 18 to 24 hrs in presence of colistin by broth microdilution method | 2019 | Bioorganic & medicinal chemistry, 05-01, Volume: 27, Issue:9 | Second-generation aryl isonitrile compounds targeting multidrug-resistant Staphylococcus aureus. |
| AID285380 | Bactericidal activity against heteroresistant vancomycin-intermediate Staphylococcus aureus Mu3 assessed as reduction of CFU using in vitro PK/PD model with human dosage regimen 120 mg every 12 hrs after 48 hrs | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Pharmacokinetic/pharmacodynamic factors influencing emergence of resistance to linezolid in an in vitro model. |
| AID406622 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae isolates assessed as percent susceptible isolates by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Prevalence, characteristics, and molecular epidemiology of macrolide and fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae at five tertiary-care hospitals in Korea. |
| AID571791 | Antibacterial activity against Clostridium difficile by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID1414199 | Selectivity ratio of MBC for methicillin-resistant Staphylococcus aureus ATCC 43300 to MIC for methicillin-resistant Staphylococcus aureus ATCC 43300 | 2018 | European journal of medicinal chemistry, Nov-05, Volume: 159 | Design, synthesis and structure-based optimization of novel isoxazole-containing benzamide derivatives as FtsZ modulators. |
| AID1151770 | Antibacterial activity against Streptococcus pyogenes isolate 556 in po dosed mouse systemic infection model | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID583892 | Antibacterial activity against vancomycin-heteroresistant Staphylococcus aureus isolate 443 by broth microdilution assay | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Comparative efficacies of human simulated exposures of telavancin and vancomycin against methicillin-resistant Staphylococcus aureus with a range of vancomycin MICs in a murine pneumonia model. |
| AID1437032 | Antimycobacterial activity against isoniazid/rifampicin/streptomycin-resistant Mycobacterium tuberculosis by microplate Alamar Blue assay | 2017 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 27, Issue:4 | Development of gallic acid formazans as novel enoyl acyl carrier protein reductase inhibitors for the treatment of tuberculosis. |
| AID68389 | In vitro antibacterial activity against vancomycin-resistant Enterococcus faecium (VRE.1) | 2003 | Bioorganic & medicinal chemistry letters, Nov-17, Volume: 13, Issue:22 | Synthesis and in vitro activity of novel isoxazolyl tetrahydropyridinyl oxazolidinone antibacterial agents. |
| AID1414200 | Selectivity ratio of MBC for clinical isolate of penicillin-resistant Staphylococcus aureus to MIC for clinical isolate of penicillin-resistant Staphylococcus aureus | 2018 | European journal of medicinal chemistry, Nov-05, Volume: 159 | Design, synthesis and structure-based optimization of novel isoxazole-containing benzamide derivatives as FtsZ modulators. |
| AID1609289 | Antibacterial activity against methicilline-sensitive Staphylococcus aureus NRS-107 after 18 to 20 hrs by CLSI-based broth microdilution assay | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Phenylthiazoles with nitrogenous side chain: An approach to overcome molecular obesity. |
| AID576678 | Bactericidal activity against 12 hrs peripheral compartment culture samples of Enterococcus faecalis Ef1497 in two-compartment pharmacokinetic/pharmacodynamic model assessed as effect on bacterial count at 800 mg, bid administered as 0.5 hr infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID498886 | Antimicrobial activity against Pseudomonas aeruginosa OC 4354 assessed as inhibition of growth by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vivo activity of ceftobiprole in murine skin infections due to Staphylococcus aureus and Pseudomonas aeruginosa. |
| AID456046 | Antibacterial activity against vancomycin-resistant Enterococcus faecium after 18 hrs by twofold microbroth dilution method | 2009 | Bioorganic & medicinal chemistry, Oct-01, Volume: 17, Issue:19 | Design, synthesis and biological evaluations of novel 7-[3-(1-aminocycloalkyl)pyrrolidin-1-yl]-6-desfluoro-8-methoxyquinolones with potent antibacterial activity against multi-drug resistant Gram-positive bacteria. |
| AID524962 | Antibacterial activity against methicillin-resistant coagulase-negative Staphylococcus simulans clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Comparative surveillance study of telavancin activity against recently collected gram-positive clinical isolates from across the United States. |
| AID558527 | Antimicrobial activity against vancomycin-resistant Staphylococcus aureus 510 measured on day 30 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID523030 | Antimicrobial activity against methicillin-resistant coagulase-negative Staphylococcus by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative in vitro antimicrobial activities of torezolid (TR-700), the active moiety of a new oxazolidinone, torezolid phosphate (TR-701), determination of tentative disk diffusion interpretive criteria, and quality control ranges. |
| AID523038 | Antimicrobial activity against streptococcal sp. by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative in vitro antimicrobial activities of torezolid (TR-700), the active moiety of a new oxazolidinone, torezolid phosphate (TR-701), determination of tentative disk diffusion interpretive criteria, and quality control ranges. |
| AID562397 | Antimicrobial activity against oxacillin-susceptible Staphylococcus aureus clinical isolates assessed as percent susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID245165 | In vitro minimum inhibitory concentration against Staphylococcus epidermidis (ATCC 12228) | 2005 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 15, Issue:12 | Synthesis and antibacterial activity of novel (un)substituted benzotriazolyl oxazolidinone derivatives. |
| AID575188 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Comparative in vitro activity profiles of novel bis-indole antibacterials against gram-positive and gram-negative clinical isolates. |
| AID729220 | Antibacterial activity against Enterococcus faecalis after 16 hrs by NCCLS agar dilution method | 2013 | Journal of medicinal chemistry, Mar-28, Volume: 56, Issue:6 | Solubility-driven optimization of (pyridin-3-yl) benzoxazinyl-oxazolidinones leading to a promising antibacterial agent. |
| AID1710606 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 33592 assessed as reduction in bacterial count at 3 x MIC incubated upto 24 hrs by time kill analysis | 2020 | RSC medicinal chemistry, Jan-01, Volume: 11, Issue:1 | Potent trifluoromethoxy, trifluoromethylsulfonyl, trifluoromethylthio and pentafluorosulfanyl containing (1,3,4-oxadiazol-2-yl)benzamides against drug-resistant Gram-positive bacteria. |
| AID1167737 | Antimicrobial activity against tolC-deficient Escherichia coli by broth microdilution method | 2014 | Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21 | Novel DNA gyrase inhibiting spiropyrimidinetriones with a benzisoxazole scaffold: SAR and in vivo characterization. |
| AID531574 | Antibacterial activity against Aerococcus viridans obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID573141 | Antibacterial activity against erythromycin-nonsusceptible Streptococcus agalactiae by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID484702 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus | 2010 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 20, Issue:12 | Potent antimicrobial activity of 3-(4,5-diaryl-1H-imidazol-2-yl)-1H-indole derivatives against methicillin-resistant Staphylococcus aureus. |
| AID1312939 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus USA400 NRS123 clinical isolate after 20 hrs by broth microdilution method | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10 | Second-Generation Phenylthiazole Antibiotics with Enhanced Pharmacokinetic Properties. |
| AID284979 | Antimicrobial activity against Corynebacterium striatum at 0.5 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID571813 | Antibacterial activity against Clostridium tertium by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID383566 | Antibacterial activity against Staphylococcus aureus ATCC 14154 by broth microdilution technique | 2008 | European journal of medicinal chemistry, Apr, Volume: 43, Issue:4 | Synthesis and in vitro antibacterial activities of novel oxazolidinones. |
| AID565009 | Antimicrobial activity against methicillin-susceptible coagulase-negative Staphylococcus haemolyticus assessed as susceptible isolates after 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID283393 | Antimicrobial activity against Nocardia abscessus after 72 hrs by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | In vitro activities of tigecycline and eight other antimicrobials against different Nocardia species identified by molecular methods. |
| AID531558 | Antibacterial activity against coagulase-negative Staphylococcus capitis obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID1596562 | Bactericidal activity against methicillin resistant Staphylococcus aureus NRS119 assessed as reduction in bacterial cell growth incubated for 18 to 20 hrs followed by re-plating on tryptic soy agar plates at 37 degC for 18 hrs by broth microdilution assay | 2019 | European journal of medicinal chemistry, Aug-01, Volume: 175 | Lipophilic efficient phenylthiazoles with potent undecaprenyl pyrophosphatase inhibitory activity. |
| AID523036 | Antimicrobial activity against vancomycin-resistant Enterococcus faecium by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative in vitro antimicrobial activities of torezolid (TR-700), the active moiety of a new oxazolidinone, torezolid phosphate (TR-701), determination of tentative disk diffusion interpretive criteria, and quality control ranges. |
| AID585158 | Antibacterial activity against Mycobacterium smegmatis harboring 23S rRNA G2032C mutant after 24 generation times | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Mutations in 23S rRNA at the peptidyl transferase center and their relationship to linezolid binding and cross-resistance. |
| AID127508 | Antibacterial activity against Moraxella catarrhalis UC30610 (M. cat) | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | Synthesis and biological evaluation of benzazepine oxazolidinone antibacterials. |
| AID576434 | Bactericidal activity against 14 hrs peripheral compartment culture samples of Staphylococcus aureus RN4220 in two-compartment pharmacokinetic/pharmacodynamic model assessed as effect on bacterial count at 600 mg, bid administered as 0.5 hr infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID405618 | Antibacterial activity against coagulase-negative Staphylococcus | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Comparative study of the effects of pyridoxine, rifampin, and renal function on hematological adverse events induced by linezolid. |
| AID523798 | Antimicrobial activity against linezolid-resistant coagulase-negative Staphylococcus assessed as percent susceptible strain by CLSI method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative activities of TR-700 (torezolid) against staphylococcal blood isolates collected in Spain. |
| AID561087 | Antibacterial activity against Streptococcus agalactiae by CLSI M7-A7 broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | In vitro activity of TR-700, the active ingredient of the antibacterial prodrug TR-701, a novel oxazolidinone antibacterial agent. |
| AID1710589 | Antibacterial activity against vancomycin- resistant Enterococcus faecalis ATCC 51299 assessed as inhibition of visible bacterial growth incubated for 18 to 20 hrs by CLSI method | 2020 | RSC medicinal chemistry, Jan-01, Volume: 11, Issue:1 | Potent trifluoromethoxy, trifluoromethylsulfonyl, trifluoromethylthio and pentafluorosulfanyl containing (1,3,4-oxadiazol-2-yl)benzamides against drug-resistant Gram-positive bacteria. |
| AID710139 | Antibacterial activity against methicillin-resistant Staphylococcus aureus | 2012 | Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22 | From triclosan toward the clinic: discovery of nonbiocidal, potent FabI inhibitors for the treatment of resistant bacteria. |
| AID576393 | Cmax in two-compartment pharmacokinetic/pharmacodynamic model at 200 mg, bid administered as 0.5 hrs infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID697276 | Antibacterial activity against hospital acquired methicillin-resistant Staphylococcus aureus ARC 1692 after 18 to 24 hrs by CLSI broth microdilution method | 2012 | Journal of medicinal chemistry, Aug-09, Volume: 55, Issue:15 | Novel N-linked aminopiperidine inhibitors of bacterial topoisomerase type II with reduced pK(a): antibacterial agents with an improved safety profile. |
| AID1409844 | Antibacterial activity against vancomycin-intermediate Staphylococcus aureus Mu50 infected in BALB/c mouse assessed as reduction of bacterial burden in heart at 0.1 mg, ip bid for 3.5 days administered 6 hrs post bacterial infection measured 84 hrs post i | 2018 | ACS medicinal chemistry letters, Mar-08, Volume: 9, Issue:3 | Novel Staphyloxanthin Inhibitors with Improved Potency against Multidrug Resistant |
| AID567568 | Antimicrobial activity against Staphylococcus aureus RN4220 harboring pBS-01multiple resistance gene cfr and phenolic resistance gene fexA obtained from swine feces | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | First report of the multidrug resistance gene cfr and the phenicol resistance gene fexA in a Bacillus strain from swine feces. |
| AID573114 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID1367598 | Inhibition of protein synthesis in Escherichia coli ribosomes incubated for 1 hr at 37 degC by SDS-PAGE and Gaussia luciferase reporter gene assay | 2017 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23 | Compound design guidelines for evading the efflux and permeation barriers of Escherichia coli with the oxazolidinone class of antibacterials: Test case for a general approach to improving whole cell Gram-negative activity. |
| AID533008 | Antibacterial activity against vancomycin-intermediate Staphylococcus aureus LIM2 phenotypic revertant after 24 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Improved antimicrobial activity of linezolid against vancomycin-intermediate Staphylococcus aureus. |
| AID1327108 | Antibacterial activity against Pseudomonas aeruginosa NCIM 2036 at 30 ug/ml measured after 8 hrs by spectrophotometric method | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Design, synthesis and biological evaluation of novel azaspiro analogs of linezolid as antibacterial and antitubercular agents. |
| AID373845 | Antimicrobial activity against vancomycin-resistant Staphylococcus aureus 510 Hershey after 14 passages with CG400549 measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID542912 | Antimicrobial activity against Bacillus anthracis infected in in vitro hollow fiber PK/PD model assessed as cell killing at 400 mg administered once every 24 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID564806 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus after 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID1680008 | Induction of inner membrane permeabilization in Escherichia coli ATCC 25922 at 20 ug/ml measured for 12 mins by propidium iodide staining based fluorescence microscopic analysis | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Synthesis and antibacterial bioactivities of cationic deacetyl linezolid amphiphiles. |
| AID548797 | Antimicrobial activity against Vancomycin-susceptible Enterococcus faecalis assessed as percent resistant isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Activities of dalbavancin against a worldwide collection of 81,673 gram-positive bacterial isolates. |
| AID775530 | Inhibition of CYP3A4 in human liver microsomes assessed as terfenadine hydroxylation after 20 mins by LC/MS/MS analysis | 2013 | European journal of medicinal chemistry, Nov, Volume: 69 | Synthesis and in vitro/in vivo antibacterial activity of oxazolidinones having thiocarbamate at C-5 on the A-ring and an amide- or urea-substituted [1,2,5]triazepane or [1,2,5]oxadiazepane as the C-ring. |
| AID284946 | Antimicrobial activity against Bacillus spp. at 0.12 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID262238 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae ATCC 700904 | 2006 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 16, Issue:6 | Novel 4-N-substituted aryl pent-2-ene-1,4-dione derivatives of piperazinyloxazolidinones as antibacterials. |
| AID278865 | Increase in lactate production in primary human osteoblasts at 400 ug/ml by ELISA relative to control | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Influence on mitochondria and cytotoxicity of different antibiotics administered in high concentrations on primary human osteoblasts and cell lines. |
| AID560504 | Antimicrobial activity against SCCmec type III vancomycin-intermediate Staphylococcus aureus isolate bd4768 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID577102 | AUBC (0 to 24 hrs) in Staphylococcus aureus RN4220 in two-compartment pharmacokinetic/pharmacodynamic model at 600 mg, bid administered as 0.5 hr infusion for 2 days | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID285091 | Antimicrobial activity against viridans group Streptococcus gordonii at 0.25 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID531560 | Antibacterial activity against coagulase-negative Staphylococcus cohnii obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID533978 | Antimicrobial activity against linezolid-susceptible Staphylococcus aureus SA040 infected in THP1 cells after 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Cellular pharmacodynamics of the novel biaryloxazolidinone radezolid: studies with infected phagocytic and nonphagocytic cells, using Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Legionella pneumophila. |
| AID287259 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus by agar dilution method | 2007 | European journal of medicinal chemistry, Feb, Volume: 42, Issue:2 | Structure-antibacterial activity of arylcarbonyl- and arylsulfonyl-piperazine 5-triazolylmethyl oxazolidinones. |
| AID1167990 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis clinical isolate 7670 after overnight incubation by two-fold serial dilution method | 2014 | Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21 | Synthesis and biological evaluation of novel peptide BF2 as an antibacterial agent against clinical isolates of vancomycin-resistant enterococci. |
| AID1415070 | Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate 6 after 16 hrs by agar dilution method | 2018 | Journal of medicinal chemistry, 12-27, Volume: 61, Issue:24 | Semisynthesis of Platensimycin Derivatives with Antibiotic Activities in Mice via Suzuki-Miyaura Cross-Coupling Reactions. |
| AID522925 | Antibacterial activity against community-acquired methicillin-resistant panton-valentine leukocidin-positive Staphylococcus aureus isolate 693 after 24 hrs by modified broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Antistaphylococcal activity of ACHN-490 tested alone and in combination with other agents by time-kill assay. |
| AID560520 | Antimicrobial activity against SCCmec type III vancomycin-intermediate Staphylococcus aureus isolate sh07043 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID1117378 | Antimicrobial activity against Staphylococcus aureus Efs4 assessed as partially clear inhibition zone at 37 degC for 24 hrs by agar diffusion method | 2010 | MedChemComm, Aug-01, Volume: 1, Issue:2 | Syntheses and biological evaluation of new cephalosporin-oxazolidinone conjugates. |
| AID207511 | Minimum inhibitory concentration against Staphylococcus aureus UC9213 | 1998 | Journal of medicinal chemistry, Sep-10, Volume: 41, Issue:19 | Piperazinyl oxazolidinone antibacterial agents containing a pyridine, diazene, or triazene heteroaromatic ring. |
| AID524966 | Antibacterial activity against vancomycin-susceptible Enterococcus faecalis clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Comparative surveillance study of telavancin activity against recently collected gram-positive clinical isolates from across the United States. |
| AID540209 | Volume of distribution at steady state in human after iv administration | 2008 | Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7 | Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. |
| AID560364 | Antimicrobial activity against vancomycin-resistant Enterococcus faecalis ATCC 51299 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Impact of human serum albumin on oritavancin in vitro activity against enterococci. |
| AID565745 | Antimicrobial activity against vancomycin-nonsusceptible Enterococcus faecium clinical isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID1400041 | Bactericidal activity against Staphylococcus aureus BAA 2094 incubated for 24 hrs under aerobic condition by MABA | 2018 | Bioorganic & medicinal chemistry, 09-15, Volume: 26, Issue:17 | An antimycobacterial pleuromutilin analogue effective against dormant bacilli. |
| AID559788 | Antimicrobial activity against heterogeneous vancomycin-susceptible Staphylococcus aureus assessed as susceptible isolates by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID278570 | Antimicrobial activity against vancomycin-susceptible Enterococcus faecalis ATCC 29212 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | In vitro activities of the lipopeptides palmitoyl (Pal)-Lys-Lys-NH(2) and Pal-Lys-Lys alone and in combination with antimicrobial agents against multiresistant gram-positive cocci. |
| AID574954 | Antimicrobial activity against multiple drug resistant Streptococcus pneumoniae serotype 19A by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID573116 | Antibacterial activity against methicillin-resistant Staphylococcus aureus by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID285103 | Antimicrobial activity against viridans group Streptococcus mitis at 0.5 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID245147 | Minimum inhibitory concentration against Haemophilus influenzae (strain A20191) in absence of calf serum | 2004 | Bioorganic & medicinal chemistry letters, Sep-20, Volume: 14, Issue:18 | Discovery of isoxazolinone antibacterial agents. Nitrogen as a replacement for the stereogenic center found in oxazolidinone antibacterials. |
| AID278568 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | In vitro activities of the lipopeptides palmitoyl (Pal)-Lys-Lys-NH(2) and Pal-Lys-Lys alone and in combination with antimicrobial agents against multiresistant gram-positive cocci. |
| AID1778656 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis ATCC 51299 assessed as bacterial growth inhibition incubated for 24 hrs by CLSI protocol based broth microdilution method | 2021 | European journal of medicinal chemistry, Oct-05, Volume: 221 | Design, synthesis and evaluation of novel 9-arylalkyl-10-methylacridinium derivatives as highly potent FtsZ-targeting antibacterial agents. |
| AID369444 | Antibacterial activity against penicillin-intermediate Streptococcus pneumoniae after 20 to 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vitro activity of telavancin against gram-positive clinical isolates recently obtained in Europe. |
| AID1451772 | Antibacterial activity against Staphylococcus aureus NRS271 infected in BALB/c mouse assessed as reduction of bacterial burden in heart at 0.4 mg, ip bid for 4.5 days treated 24 hrs prior to bacterial infection measured 108 hrs post infection relative to | 2017 | Journal of medicinal chemistry, 10-12, Volume: 60, Issue:19 | Novel Inhibitors of Staphyloxanthin Virulence Factor in Comparison with Linezolid and Vancomycin versus Methicillin-Resistant, Linezolid-Resistant, and Vancomycin-Intermediate Staphylococcus aureus Infections in Vivo. |
| AID245007 | Antibacterial activity against Staphylococcus epidermidis 56500 was determined | 2004 | Bioorganic & medicinal chemistry letters, Oct-18, Volume: 14, Issue:20 | Synthesis and antibacterial activity of novel 6-fluoro-1-[(1R,2S)-2-fluorocyclopropan-1-yl]-4-oxoquinoline-3-carboxylic acids bearing cyclopropane-fused 2-amino-8-azabicyclo[4.3.0]nonan-8-yl substituents at the C-7 position. |
| AID562191 | Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus 1287 measured after 10 antibiotic-free subculturing by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID1553376 | Aqueous solubility of compound | 2019 | Bioorganic & medicinal chemistry letters, 09-15, Volume: 29, Issue:18 | Incorporation of a chiral gem-disubstituted nitrogen heterocycle yields an oxazolidinone antibiotic with reduced mitochondrial toxicity. |
| AID261061 | Antibacterial activity against Staphylococcus aureus UC-76 SA-1 | 2006 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 16, Issue:5 | Conformational constraint in oxazolidinone antibacterials. Part 2: Synthesis and structure-activity studies of oxa-, aza-, and thiabicyclo[3.1.0]hexylphenyl oxazolidinones. |
| AID524942 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Comparative surveillance study of telavancin activity against recently collected gram-positive clinical isolates from across the United States. |
| AID278910 | Antibacterial activity against linezolid-resistant methicillin-resistant Staphylococcus aureus | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | In vitro antibacterial activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. |
| AID1400060 | Bactericidal activity against Streptococcus salivarius ATCC 6301 incubated for 24 hrs under aerobic condition by MABA | 2018 | Bioorganic & medicinal chemistry, 09-15, Volume: 26, Issue:17 | An antimycobacterial pleuromutilin analogue effective against dormant bacilli. |
| AID529822 | Bactericidal activity against hospital-acquired methicillin-resistant Staphylococcus aureus by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Activities of ceftobiprole, linezolid, vancomycin, and daptomycin against community-associated and hospital-associated methicillin-resistant Staphylococcus aureus. |
| AID373825 | Antimicrobial activity against panton-valentine leukocidin-negative community-acquired methicillin-resistant Staphylococcus aureus 481 after 14 passages with daptomycin measured after 10 antibiotic-free subculture by multi-step resistance selection techni | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID285059 | Antimicrobial activity against beta hemolytic Streptococci group C at <= 0.06 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID533967 | Antimicrobial activity against linezolid-susceptible Staphylococcus aureus ATCC 25923 infected in THP1 cells assessed as log reduction in bacterial count after 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Cellular pharmacodynamics of the novel biaryloxazolidinone radezolid: studies with infected phagocytic and nonphagocytic cells, using Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Legionella pneumophila. |
| AID1271208 | Metabolic stability in rat plasma by LC-MS/MS analysis | 2015 | ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11 | Design, Synthesis, and Identification of Silicon Incorporated Oxazolidinone Antibiotics with Improved Brain Exposure. |
| AID263961 | Antibacterial activity against methicillin-resistant Staphylococcus aureus DRCC 019 | 2006 | Bioorganic & medicinal chemistry letters, May-01, Volume: 16, Issue:9 | Synthesis and antibacterial activity of novel oxazolidinones bearing N-hydroxyacetamidine substituent. |
| AID583202 | Antimicrobial activity against vancomycin-heteroresistant Staphylococcus aureus after 24 hrs by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | In vitro activity of the new multivalent glycopeptide-cephalosporin antibiotic TD-1792 against vancomycin-nonsusceptible Staphylococcus isolates. |
| AID561755 | Antibacterial activity against Methicillin-sensitive Staphylococcus aureus assessed as resistant isolates by CLSI broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Potency and bactericidal activity of iclaprim against recent clinical gram-positive isolates. |
| AID541034 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 infected in Albino guiena pig assessed as decrease in planktonic bacterial counts in cage fluid at 75 mg/kg after measured on day 10 postinfection | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Linezolid alone or combined with rifampin against methicillin-resistant Staphylococcus aureus in experimental foreign-body infection. |
| AID1710590 | Antibacterial activity against vancomycin- resistant Enterococcus faecalis ATCC 700221 assessed as inhibition of visible bacterial growth incubated for 18 to 20 hrs by CLSI method | 2020 | RSC medicinal chemistry, Jan-01, Volume: 11, Issue:1 | Potent trifluoromethoxy, trifluoromethylsulfonyl, trifluoromethylthio and pentafluorosulfanyl containing (1,3,4-oxadiazol-2-yl)benzamides against drug-resistant Gram-positive bacteria. |
| AID1308266 | Drug level in uninfected thighs of ICR mouse neutropenic thigh model of methicillin-resistant Staphylococcus aureus NRS70 infection at 10 mg/kg, sc tid administered every 8 hrs starting from 1 hr post infection and measured 7 hrs post last dose by UPLC an | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10 | Structure-Activity Relationship for the 4(3H)-Quinazolinone Antibacterials. |
| AID326290 | Antibacterial activity against methicillin-resistant Staphylococcus aureus 4803 at 4 hrs daily exposure for 5 days by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Comparative activities of daptomycin, linezolid, and tigecycline against catheter-related methicillin-resistant Staphylococcus bacteremic isolates embedded in biofilm. |
| AID1609261 | Bactericidal activity against Listeria monocytogenes ATCC 19111 incubated for 18 to 20 hrs followed by replating on tryptic soy agar plate and further incubated for 18 to 24 hrs by CLSI-based broth microdilution assay | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Phenylthiazoles with nitrogenous side chain: An approach to overcome molecular obesity. |
| AID245274 | Minimum inhibitory concentration against methicillin-resistant Staphylococcus epidermidis UC12084 | 2005 | Journal of medicinal chemistry, Jul-28, Volume: 48, Issue:15 | Conformational constraint in oxazolidinone antibacterials. Synthesis and structure-activity studies of (azabicyclo[3.1.0]hexylphenyl)oxazolidinones. |
| AID284988 | Antimicrobial activity against Enterococcus casseliflavus at 0.12 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID1474210 | Bactericidal activity against vancomycin-resistant Enterococcus faecalis clinical isolates after 18 to 22 hrs by broth microdilution method | 2017 | Journal of medicinal chemistry, 03-23, Volume: 60, Issue:6 | Phenylthiazole Antibacterial Agents Targeting Cell Wall Synthesis Exhibit Potent Activity in Vitro and in Vivo against Vancomycin-Resistant Enterococci. |
| AID285344 | Antibacterial activity against community acquired methicillin-resistant Staphylococcus aureus HT20040332 in Mueller-Hinton medium | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Effect of antibiotics on Staphylococcus aureus producing Panton-Valentine leukocidin. |
| AID542889 | fCmax in Bacillus anthracis infected in vitro hollow fiber PK/PD model at simulated dose of 200 mg administered every 12 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID368281 | Cmax in rabbit plasma at 58 mg/kg infused every 12 hrs for 4 days | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vivo efficacy of ceftaroline (PPI-0903), a new broad-spectrum cephalosporin, compared with linezolid and vancomycin against methicillin-resistant and vancomycin-intermediate Staphylococcus aureus in a rabbit endocarditis model. |
| AID509632 | Antimicrobial activity against Staphylococcus aureus 25 transformant carrying plasmid pKKS25 and expressing erm(T), dfrKtet(L), tet(K), tet(M), mecA and blaZ genes by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Identification of a plasmid-borne resistance gene cluster comprising the resistance genes erm(T), dfrK, and tet(L) in a porcine methicillin-resistant Staphylococcus aureus ST398 strain. |
| AID1414195 | Bactericidal activity against Staphylococcus aureus ATCC 25923 incubated for 24 hrs followed by plating onto tryptic soy agar plates and further incubated for 24 hrs by broth microdilution based CLSI method | 2018 | European journal of medicinal chemistry, Nov-05, Volume: 159 | Design, synthesis and structure-based optimization of novel isoxazole-containing benzamide derivatives as FtsZ modulators. |
| AID404936 | Antibacterial activity against methicillin-resistant coagulase-negative Staphylococcus sp. by CLSI dilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro activities of CG400549, a novel FabI inhibitor, against recently isolated clinical staphylococcal strains in Korea. |
| AID499116 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus OC 8525 infected immunocompromized SKH1 mouse assessed as lesion volume at 25 mg/kg/day, sc measured after 48 hrs postinfection (Rvb = 1535 mm3) | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vivo activity of ceftobiprole in murine skin infections due to Staphylococcus aureus and Pseudomonas aeruginosa. |
| AID572014 | Antibacterial activity against Prevotella P denticola by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID1778101 | Antibacterial activity against linezolid resistant Enterococcus faecalis assessed as bacterial growth inhibition after 18 hrs by broth microdilution method | |||
| AID562620 | Antimicrobial activity against vancomycin-resistant Staphylococcus aureus by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | In vitro activities of three new dihydrofolate reductase inhibitors against clinical isolates of gram-positive bacteria. |
| AID373815 | Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus 555 Hershey after 50 passages by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID522885 | Antibacterial activity against vancomycin-resistant Staphylococcus aureus isolate 1264 after 24 hrs by modified broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Antistaphylococcal activity of ACHN-490 tested alone and in combination with other agents by time-kill assay. |
| AID542683 | fAUC (24 hrs) in Bacillus anthracis infected in vitro hollow fiber PK/PD model at simulated dose of 400 mg administered every 24 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID244902 | Minimal inhibitory concentration against Enterococcus durans ATCC 581 | 2004 | Bioorganic & medicinal chemistry letters, Sep-20, Volume: 14, Issue:18 | Synthesis and antibacterial activity of some aryloxy/thioaryloxy oxazolidinone derivatives. |
| AID522894 | Antibacterial activity against vancomycin-intermediate Staphylococcus aureus isolate 1011 after 24 hrs by modified broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Antistaphylococcal activity of ACHN-490 tested alone and in combination with other agents by time-kill assay. |
| AID1609276 | Bactericidal activity against methicilline-resistant Staphylococcus aureus NRS123 USA400 incubated for 18 to 20 hrs followed by replating on tryptic soy agar plate and further incubated for 18 to 24 hrs by CLSI-based broth microdilution assay | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Phenylthiazoles with nitrogenous side chain: An approach to overcome molecular obesity. |
| AID1180571 | Antimicrobial activity against 2 times drug resistance selected Staphylococcus aureus ARC516-2F by broth microdilution/CLSI method | 2014 | Journal of medicinal chemistry, Jul-24, Volume: 57, Issue:14 | Optimization of pyrrolamide topoisomerase II inhibitors toward identification of an antibacterial clinical candidate (AZD5099). |
| AID1596564 | Bactericidal activity against vancomycin resistant Staphylococcus aureus VRS10 assessed as reduction in bacterial cell growth incubated for 18 to 20 hrs followed by re-plating on tryptic soy agar plates at 37 degC for 18 hrs by broth microdilution assay | 2019 | European journal of medicinal chemistry, Aug-01, Volume: 175 | Lipophilic efficient phenylthiazoles with potent undecaprenyl pyrophosphatase inhibitory activity. |
| AID562622 | Antimicrobial activity against Coagulase-negative Staphylococcus by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | In vitro activities of three new dihydrofolate reductase inhibitors against clinical isolates of gram-positive bacteria. |
| AID1703730 | Antibacterial activity against cephalosporin-resistant Streptococcus pneumoniae ATCC 51916 assessed as inhibition of bacterial growth measured after 18 to 20 hrs by CLSI protocol based broth microdilution method | 2020 | European journal of medicinal chemistry, Sep-15, Volume: 202 | Evaluation of N-phenyl-2-aminothiazoles for treatment of multi-drug resistant and intracellular Staphylococcus aureus infections. |
| AID1710588 | Antibacterial activity against methicillin- resistant Streptococcus pneumoniae ATCC 700677 assessed as inhibition of visible bacterial growth incubated for 18 to 20 hrs by CLSI method | 2020 | RSC medicinal chemistry, Jan-01, Volume: 11, Issue:1 | Potent trifluoromethoxy, trifluoromethylsulfonyl, trifluoromethylthio and pentafluorosulfanyl containing (1,3,4-oxadiazol-2-yl)benzamides against drug-resistant Gram-positive bacteria. |
| AID534156 | Antimicrobial activity against linezolid-resistant Enterococcus faecium 854 harboring G2576U mutation in peptidyl transferase centre by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains. |
| AID581021 | Inhibition of DNA synthesis in Staphylococcus epidermidis ATCC 23760 assessed as incorporation of [3H]thymidine at 2 ug/ml by liquid scintillation counter | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Mode of action of Ranbezolid against staphylococci and structural modeling studies of its interaction with ribosomes. |
| AID562394 | Antimicrobial activity against oxacillin-susceptible Staphylococcus epidermidis clinical isolates assessed as percent susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID1151765 | Antibacterial activity against penicillin-sensitive Streptococcus pneumoniae isolate 0806 in po dosed mouse systemic infection model | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID541781 | Antimicrobial activity against penicillin-resistant Streptococcus pneumoniae clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID519082 | Antimicrobial activity against Escherichia coli KM69-73 harboring G2576U mutation in 23S rRNA by agar dilution method in presence of 16 ug/ml polymyxin B nonapeptide | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Linezolid and tiamulin cross-resistance in Staphylococcus aureus mediated by point mutations in the peptidyl transferase center. |
| AID244869 | Minimum inhibitory concentration against Klebsiella pneumoniae ATCC 13383 | 2004 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 14, Issue:22 | Aryl urea analogs with broad-spectrum antibacterial activity. |
| AID308489 | Antibacterial activity against Haemophilus influenzae HI3542 | 2007 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 17, Issue:16 | Synthesis and SAR of novel conformationally restricted oxazolidinones possessing gram-positive and fastidious gram-negative antibacterial activity. Part 2: Amino substitutions on heterocyclic D-ring system. |
| AID1400027 | Selectivity index, ratio of IC50 for African green monkey Vero cells to MIC100 for replicating Mycobacterium tuberculosis H37Rv by MABA | 2018 | Bioorganic & medicinal chemistry, 09-15, Volume: 26, Issue:17 | An antimycobacterial pleuromutilin analogue effective against dormant bacilli. |
| AID511302 | Antibacterial activity against methicillin susceptible Staphylococcus aureus by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Comparative in vitro activities of nemonoxacin (TG-873870), a novel nonfluorinated quinolone, and other quinolones against clinical isolates. |
| AID561248 | Antibacterial activity against methicillin-resistant Staphylococcus epidermidis assessed as resistant isolates by CLSI M100-S17 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | AFN-1252, a FabI inhibitor, demonstrates a Staphylococcus-specific spectrum of activity. |
| AID1578428 | Antimicrobial activity against methicillin-resistant Staphylococcus epidermidis NRS101 by broth liquid microdilution method | 2020 | European journal of medicinal chemistry, Jan-01, Volume: 185 | Modifying the lipophilic part of phenylthiazole antibiotics to control their drug-likeness. |
| AID326285 | Antibacterial activity against methicillin-resistant Staphylococcus aureus 859 at 4 hrs daily exposure for 1 day by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Comparative activities of daptomycin, linezolid, and tigecycline against catheter-related methicillin-resistant Staphylococcus bacteremic isolates embedded in biofilm. |
| AID548525 | Antimicrobial activity against Oxacillin-susceptible Staphylococcus aureus by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Activities of dalbavancin against a worldwide collection of 81,673 gram-positive bacterial isolates. |
| AID576431 | Bactericidal activity against 12 hrs peripheral compartment culture samples of Staphylococcus aureus RN4220 in two-compartment pharmacokinetic/pharmacodynamic model assessed as effect on bacterial count at 600 mg, bid administered as 0.5 hr infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID604290 | Antibacterial activity against Enterococcus faecalis ATCC 29212 after 16 to 24 hrs by twofold serial dilution method | 2011 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 21, Issue:14 | 7-Alkyl-N(2)-substituted-3-deazaguanines. Synthesis, DNA polymerase III inhibition and antibacterial activity. |
| AID1852675 | Antibacterial activity against multidrug resistant Acinetobacter baumannii AYE assessed as inhibition of bacterial growth incubated for 24 hrs in MHI medium by twofold serial dilution method | |||
| AID571806 | Antibacterial activity against Clostridium orbiscindens by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID560804 | Cmax in human adults with pulmonary tuberculosis at 600 mg administered daily for 7 days | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Population pharmacokinetics of linezolid in adults with pulmonary tuberculosis. |
| AID245123 | In vitro antibacterial activity against Staphylococcus aureus; value ranges from 3-6 uM | 2004 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 14, Issue:22 | Aryl urea analogs with broad-spectrum antibacterial activity. |
| AID519138 | Antimicrobial activity against community-acquired methicillin resistant Staphylococcus aureus expressing PVL and mec type IV gene by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Antimicrobial activities of Ceftaroline and ME1036 tested against clinical strains of community-acquired methicillin-resistant Staphylococcus aureus. |
| AID617501 | Antibacterial activity against methicillin-resistant Staphylococcus aureus 43300 by CLSI method | 2011 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 21, Issue:18 | Synthesis and in vitro activity of novel 1,2,4-triazolo[4,3-a]pyrimidine oxazolidinone antibacterial agents. Part II. |
| AID245128 | Minimum inhibitory concentration against Enterococcus faecalis (strain A20688) in absence of calf serum | 2004 | Bioorganic & medicinal chemistry letters, Sep-20, Volume: 14, Issue:18 | Discovery of isoxazolinone antibacterial agents. Nitrogen as a replacement for the stereogenic center found in oxazolidinone antibacterials. |
| AID245217 | Minimum inhibitory concentration against Staphylococcus aureus (strain A15090) in presence of 50% calf serum | 2004 | Bioorganic & medicinal chemistry letters, Sep-20, Volume: 14, Issue:18 | Discovery of isoxazolinone antibacterial agents. Nitrogen as a replacement for the stereogenic center found in oxazolidinone antibacterials. |
| AID1778669 | Ratio of MBC to MIC against penicillin-resistant Staphylococcus epidermidis | 2021 | European journal of medicinal chemistry, Oct-05, Volume: 221 | Design, synthesis and evaluation of novel 9-arylalkyl-10-methylacridinium derivatives as highly potent FtsZ-targeting antibacterial agents. |
| AID577093 | Ratio of AUC (0 to 24 hrs) to MIC for Enterococcus faecalis Ef1497 MutM3 in two-compartment pharmacokinetic/pharmacodynamic model at 600 mg, bid administered as 0.5 hr infusion for 2 days | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID1076825 | Antitubercular activity against Mycobacterium tuberculosis H37RV ATCC 27294 assessed as growth inhibition after 3 to 11 days by microdilution method | 2014 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 24, Issue:6 | Discovery of novel bis-oxazolidinone compounds as potential potent and selective antitubercular agents. |
| AID1151627 | Toxicity in female rat assessed as effect on platelet count at 100 mg/kg/day, po bid administered for 4 weeks (Rvb = 654.6 x 10'9/L) | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID1350036 | Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate 7 incubated overnight by agar dilution method | 2018 | Journal of natural products, 02-23, Volume: 81, Issue:2 | Biomimetic Stereoselective Sulfa-Michael Addition Leads to Platensimycin and Platencin Sulfur Analogues against Methicillin-Resistant Staphylococcus aureus. |
| AID745407 | Antibacterial activity against Staphylococcus aureus SR20549 clinical isolate assessed as growth inhibition by CLSI broth microdilution method | 2013 | European journal of medicinal chemistry, May, Volume: 63 | Antibacterial oxazolidinone analogues having a N-hydroxyacetyl-substituted seven-membered [1,2,5]triazepane or [1,2,5]oxadiazepane C-ring unit. |
| AID285123 | Antimicrobial activity against viridans group Streptococcus parasanguis at 1 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID1395681 | Antibacterial activity against vancomycin-resistant Staphylococcus aureus VRS12 after 18 hrs by broth microdilution assay | 2018 | European journal of medicinal chemistry, May-10, Volume: 151 | Phenylthiazoles with tert-Butyl side chain: Metabolically stable with anti-biofilm activity. |
| AID326299 | Antibacterial activity against methicillin-resistant Staphylococcus aureus 789 at 4 hrs daily exposure for 5 days by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Comparative activities of daptomycin, linezolid, and tigecycline against catheter-related methicillin-resistant Staphylococcus bacteremic isolates embedded in biofilm. |
| AID591660 | Antimicrobial activity against multidrug-resistant Staphylococcus aureus after 18 hrs by agar dilution method | 2011 | Journal of medicinal chemistry, Apr-14, Volume: 54, Issue:7 | A new DNA gyrase inhibitor subclass of the cyclothialidine family based on a bicyclic dilactam-lactone scaffold. Synthesis and antibacterial properties. |
| AID475001 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis LCB0006 by two fold serial dilution method | 2010 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 20, Issue:7 | Synthesis, crystal and antibacterial studies of diversely functionalized tetrahydropyridin-4-ol. |
| AID571793 | Antibacterial activity against Clostridium innocuum by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID571828 | Antibacterial activity against Holdemania filiformis by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID1649294 | Antibacterial activity against Escherichia coli JC2 assessed as inhibition of bacterial growth incubated for 20 hrs by microdilution broth method | |||
| AID319170 | Protection against methicillin-resistant Staphylococcus aureus infection in pneumonia patient | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7 | Linezolid (ZYVOX), the first member of a completely new class of antibacterial agents for treatment of serious gram-positive infections. |
| AID373831 | Antimicrobial activity against panton-valentine leukocidin-positive community-acquired methicillin-resistant Staphylococcus aureus 490 after 22 passages with Linezolid measured after 10 antibiotic-free subculture by multi-step resistance selection techniq | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID1312952 | Bactericidal activity against vancomycin-resistant Enterococcus faecium ATCC 700221 after 20 hrs by broth microdilution method | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10 | Second-Generation Phenylthiazole Antibiotics with Enhanced Pharmacokinetic Properties. |
| AID318369 | Inhibition of fatty acid synthesis in Streptococcus pneumoniae in whole cell activity assay | 2007 | Proceedings of the National Academy of Sciences of the United States of America, May-01, Volume: 104, Issue:18 | Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties. |
| AID541528 | Antimicrobial activity against Staphylococcus haemolyticus clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID561241 | Antibacterial activity against methicillin-susceptible Staphylococcus epidermidis by CLSI M100-S17 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | AFN-1252, a FabI inhibitor, demonstrates a Staphylococcus-specific spectrum of activity. |
| AID206863 | Antibacterial activity against Methicillin-resistant Staphylococcus aureus UC6685 (S. a.) | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | Synthesis and biological evaluation of benzazepine oxazolidinone antibacterials. |
| AID285038 | Antimicrobial activity against Bacillus cereus by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID1303419 | Antibacterial activity against methicillin-resistant Staphylococcus aureus infected in po dosed mouse model assessed as inhibition of systemic infection administered bid for 3 days | 2016 | Bioorganic & medicinal chemistry letters, 07-01, Volume: 26, Issue:13 | Identification of novel aminopiperidine derivatives for antibacterial activity against Gram-positive bacteria. |
| AID562193 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus 547 measured after 10 antibiotic-free subculturing by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID1770366 | Bactericidal activity against Vancomycin-resistant Enterococcus faecium ATCC 51559 assessed as inhibition of bacterial growth measured after 20 hrs by two-fold microdilution assay | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Modification of 5-methylphenanthridium from benzothiazoles to indoles as potent FtsZ inhibitors: Broadening the antibacterial spectrum toward vancomycin-resistant enterococci. |
| AID524963 | Antibacterial activity against methicillin-resistant coagulase-negative Staphylococcus warneri clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Comparative surveillance study of telavancin activity against recently collected gram-positive clinical isolates from across the United States. |
| AID1861531 | Terminal half life in Wistar rat at 15 mg/kg, iv | 2022 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 71 | WCK 4034: A promising oxazolidinone for treating gram positive infections. |
| AID1435926 | Antibacterial activity against vancomycin-resistant Staphylococcus aureus VRSA4 clinical isolate after 18 to 20 hrs by broth microdilution method | 2017 | European journal of medicinal chemistry, Jan-27, Volume: 126 | Phenylthiazole antibiotics: A metabolism-guided approach to overcome short duration of action. |
| AID519481 | Antibacterial activity against Staphylococcus aureus T991 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Linezolid resistance in Staphylococcus aureus: gene dosage effect, stability, fitness costs, and cross-resistances. |
| AID562163 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus 525 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID534159 | Antimicrobial activity against linezolid-resistant Enterococcus faecalis by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains. |
| AID1303421 | Antibacterial activity against Penicillin-resistant Streptococcus pneumoniae yonsei 15 infected in po dosed immunosuppressed mouse model assessed as inhibition of pulmonary infection administered bid for 3 days | 2016 | Bioorganic & medicinal chemistry letters, 07-01, Volume: 26, Issue:13 | Identification of novel aminopiperidine derivatives for antibacterial activity against Gram-positive bacteria. |
| AID645044 | Antibacterial activity against Streptococcus pneumoniae PEN-1 after 16 to 20 hrs by microbroth dilution method | 2012 | European journal of medicinal chemistry, Apr, Volume: 50 | Synthesis and preliminary antibacterial evaluation of Linezolid-like 1,2,4-oxadiazole derivatives. |
| AID583392 | Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus isolate NJ992 assessed as bacterial count at 8 times MIC after 24 hrs by colony counting method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | In vitro activity of the new multivalent glycopeptide-cephalosporin antibiotic TD-1792 against vancomycin-nonsusceptible Staphylococcus isolates. |
| AID1698677 | Antibacterial activity against Methicillin-resistant Staphylococcus aureus by CLSI method | 2020 | Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22 | Lead optimization of 8-(methylamino)-2-oxo-1,2-dihydroquinolines as bacterial type II topoisomerase inhibitors. |
| AID1591562 | Bactericidal activity against penicillin-resistant Staphylococcus aureus clinical isolate assessed as 3 log reduction in number of colony forming units incubated for 24 hrs followed by aliquots transfer to tryptic soy agar and grown for 24 hrs | 2019 | Bioorganic & medicinal chemistry, 07-15, Volume: 27, Issue:14 | Discovery of 1,3,4-oxadiazol-2-one-containing benzamide derivatives targeting FtsZ as highly potent agents of killing a variety of MDR bacteria strains. |
| AID285061 | Antimicrobial activity against beta hemolytic Streptococci group F at 0.25 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID533932 | Antimicrobial activity against linezolid-resistant methicillin-resistant Staphylococcus aureus NRS121 harboring G2576U mutation in peptidyl transferase centre by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains. |
| AID561092 | Antibacterial activity against Bacteroides thetaiotaomicron by CLSI M11-A7 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | In vitro activity of TR-700, the active ingredient of the antibacterial prodrug TR-701, a novel oxazolidinone antibacterial agent. |
| AID1414189 | Antibacterial activity against Bacillus pumilus CMCC63202 after 24 hrs by broth microdilution based CLSI method | 2018 | European journal of medicinal chemistry, Nov-05, Volume: 159 | Design, synthesis and structure-based optimization of novel isoxazole-containing benzamide derivatives as FtsZ modulators. |
| AID571989 | Antibacterial activity against Ruminococcus productus by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID533927 | Antimicrobial activity against Staphylococcus aureus 1651 harboring G2576U mutation in peptidyl transferase centre by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains. |
| AID717210 | Antimicrobial activity against methicillin-sensitive Staphylococcus aureus CCARM 0205 incubated for 24 hrs by microtiter broth dilution method | 2012 | Journal of natural products, Dec-28, Volume: 75, Issue:12 | Antibacterial butenolides from the Korean tunicate Pseudodistoma antinboja. |
| AID1421231 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus clinical isolates by broth liquid microdilution method | 2018 | European journal of medicinal chemistry, Oct-05, Volume: 158 | Synthesis and antibacterial activity evaluation of novel biaryloxazolidinone analogues containing a hydrazone moiety as promising antibacterial agents. |
| AID1304827 | Antibiofilm activity against methicillin-resistant Staphylococcus aureus isolate 2 assessed as biofilm eradication incubated for 24 hrs by CBD assay | 2016 | Journal of medicinal chemistry, 04-28, Volume: 59, Issue:8 | Structure-Activity Relationships of a Diverse Class of Halogenated Phenazines That Targets Persistent, Antibiotic-Tolerant Bacterial Biofilms and Mycobacterium tuberculosis. |
| AID1687308 | Antibacterial activity against Escherichia coli ATCC 25922 incubated for 18 to 20 hrs by broth microdilution method | 2020 | European journal of medicinal chemistry, Jan-15, Volume: 186 | Development of benzimidazole-based derivatives as antimicrobial agents and their synergistic effect with colistin against gram-negative bacteria. |
| AID1361098 | Bacteriostatic activity against methicillin-resistant Staphylococcus aureus USA400 NRS123 clinical isolate after 20 hrs by broth microdilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | N-(1,3,4-oxadiazol-2-yl)benzamide analogs, bacteriostatic agents against methicillin- and vancomycin-resistant bacteria. |
| AID285351 | Antibacterial activity against community acquired methicillin-resistant Staphylococcus aureus HT20041010 in CCY media | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Effect of antibiotics on Staphylococcus aureus producing Panton-Valentine leukocidin. |
| AID369672 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus Smith by dilution susceptibility test | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vivo efficacy of a novel oxazolidinone compound in two mouse models of infection. |
| AID576657 | Bactericidal activity against 0.5 hrs peripheral compartment culture samples of Enterococcus faecalis ATCC 29212 in two-compartment pharmacokinetic/pharmacodynamic model assessed as effect on bacterial count at 600 mg, bid administered as 0.5 hr infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID1547719 | Antibacterial activity against vancomycin-resistant Enterococcus faecium 106 clinical isolate by broth microdilution method | 2020 | ACS medicinal chemistry letters, Mar-12, Volume: 11, Issue:3 | Structure-Activity Relationship for the Oxadiazole Class of Antibacterials. |
| AID369437 | Antimicrobial activity against methicillin-susceptible coagulase-negative Staphylococcus after 20 to 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vitro activity of telavancin against gram-positive clinical isolates recently obtained in Europe. |
| AID542884 | fAUC (24 hrs) in Bacillus anthracis infected in vitro hollow fiber PK/PD model at simulated dose of 800 mg administered as 2 divided doses every 12 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID558083 | Antimicrobial activity against Mycoplasma pneumoniae isolated from human by two fold serial dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Comparative in vitro susceptibilities of human mycoplasmas and ureaplasmas to a new investigational ketolide, CEM-101. |
| AID637979 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after overnight incubation by twofold broth dilution technique in presence of 10% human serum | 2012 | Bioorganic & medicinal chemistry, Jan-01, Volume: 20, Issue:1 | Efficient microwave-assisted synthesis, antibacterial activity and high fluorescence of 5 benzimidazolyl-2'-deoxyuridines. |
| AID206238 | In vitro antibacterial activity against Staphylococcus aures strain UC12673 | 1996 | Journal of medicinal chemistry, Feb-02, Volume: 39, Issue:3 | Synthesis and antibacterial activity of U-100592 and U-100766, two oxazolidinone antibacterial agents for the potential treatment of multidrug-resistant gram-positive bacterial infections. |
| AID1151780 | Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate 0605 in mouse thigh infection model assessed as reduction of log10 CFU per thigh at 80 mg/kg, po | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID541534 | Antimicrobial activity against Enterococcus faecium clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID1304836 | Antibacterial activity against methicillin-resistant Staphylococcus epidermidis ATCC 35984 incubated for 16 to 18 hrs by broth microdilution method | 2016 | Journal of medicinal chemistry, 04-28, Volume: 59, Issue:8 | Structure-Activity Relationships of a Diverse Class of Halogenated Phenazines That Targets Persistent, Antibiotic-Tolerant Bacterial Biofilms and Mycobacterium tuberculosis. |
| AID523786 | Antimicrobial activity against linezolid-resistant Staphylococcus aureus assessed as inhibition of microbial growth at 16 ug/ml by CLSI method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative activities of TR-700 (torezolid) against staphylococcal blood isolates collected in Spain. |
| AID519488 | Antibacterial activity against Staphylococcus aureus T1910 expressing 23S rrn2 G2576T, rrn3 G2576T, rrn4 G2576T and rrn5 G2576T mutants by Etest method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Linezolid resistance in Staphylococcus aureus: gene dosage effect, stability, fitness costs, and cross-resistances. |
| AID576414 | Apparent volume of distribution in two-compartment pharmacokinetic/pharmacodynamic model at 200 mg, bid administered as 0.5 hrs infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID1180581 | Ratio of MIC for 2 times drug resistance selected Staphylococcus aureus ARC516-1F to MIC for Staphylococcus aureus ARC516 | 2014 | Journal of medicinal chemistry, Jul-24, Volume: 57, Issue:14 | Optimization of pyrrolamide topoisomerase II inhibitors toward identification of an antibacterial clinical candidate (AZD5099). |
| AID1594360 | Antibacterial activity against methicillin-resistant Staphylococcus aureus NRS385 USA500 after 18 to 24 hrs by broth microdilution assay | 2019 | Bioorganic & medicinal chemistry, 05-01, Volume: 27, Issue:9 | Second-generation aryl isonitrile compounds targeting multidrug-resistant Staphylococcus aureus. |
| AID67243 | In vitro antibacterial activity against Enterococcus faecalis C6291 (E.f.1). | 1999 | Bioorganic & medicinal chemistry letters, Sep-20, Volume: 9, Issue:18 | Synthesis and in vitro activity of new oxazolidinone antibacterial agents having substituted isoxazoles. |
| AID1474207 | Bactericidal activity against Vancomycin-resistant Enterococcus faecium clinical isolates after 18 to 22 hrs by broth microdilution method | 2017 | Journal of medicinal chemistry, 03-23, Volume: 60, Issue:6 | Phenylthiazole Antibacterial Agents Targeting Cell Wall Synthesis Exhibit Potent Activity in Vitro and in Vivo against Vancomycin-Resistant Enterococci. |
| AID297123 | Antibacterial activity against Linezolid and methicillin-resistant Staphylococcus aureus 06 after 18 hrs by agar plate dilution method | 2007 | Journal of medicinal chemistry, Aug-23, Volume: 50, Issue:17 | Discovery of 1,4-dihydroxy-2-naphthoate [corrected] prenyltransferase inhibitors: new drug leads for multidrug-resistant gram-positive pathogens. |
| AID373812 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus 547 after 48 passages by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID444051 | Total clearance in human | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3 | Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. |
| AID284968 | Antimicrobial activity against Corynebacterium jeikeium at 0.25 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID303916 | Antibacterial activity against Streptococcus pyogenes ATCC 19615 after 24 hrs by agar dilution method | 2007 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 17, Issue:24 | Synthesis and antibacterial activity of potent heterocyclic oxazolidinones and the identification of RBx 8700. |
| AID571991 | Antibacterial activity against Ruminococcus sp. by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID284957 | Antimicrobial activity against Corynebacterium spp. at <= 0.06 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID559367 | Antimicrobial activity against compound-resistant Coxiella burnetii isolate CP2 obtained from patient with acute Q fever infected in african green monkey Vero cells after 24 hrs by shell vial assay | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Bacteriostatic and bactericidal activities of tigecycline against Coxiella burnetii and comparison with those of six other antibiotics. |
| AID625292 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) combined score | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID1151624 | Toxicity in female rat assessed as effect on hematocrit level at 100 mg/kg/day, po bid administered for 4 weeks (Rvb = 39.08%) | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID645038 | Antibacterial activity against erythromycin-sensitive Streptococcus pyogenes 12 after 16 to 20 hrs by microbroth dilution method | 2012 | European journal of medicinal chemistry, Apr, Volume: 50 | Synthesis and preliminary antibacterial evaluation of Linezolid-like 1,2,4-oxadiazole derivatives. |
| AID499164 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus Smith OC 4172 infected in SKH1 mouse assessed as log change in bacterial colony forming unit per gram of skin tissue at 100 mg/kg/day, po (Rvb = 1.6 deltalog CFU) | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vivo activity of ceftobiprole in murine skin infections due to Staphylococcus aureus and Pseudomonas aeruginosa. |
| AID1367597 | Permeability index, ratio of MIC for wild type Escherichia coli MG1655 to MIC for Escherichia coli MG1655 membrane permeabilized mutant in presence of polymyxinnonapeptide | 2017 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23 | Compound design guidelines for evading the efflux and permeation barriers of Escherichia coli with the oxazolidinone class of antibacterials: Test case for a general approach to improving whole cell Gram-negative activity. |
| AID283386 | Increase in Cytochrome C oxidase 2 mitochondrial RNA transcripts in PBMCs from patient on a long-term schedule of the drug with hyperlactatemia relative to control | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Reversible inhibition of mitochondrial protein synthesis during linezolid-related hyperlactatemia. |
| AID1680050 | Antibacterial activity against carbapenem-resistant Klebsiella pneumoniae clinical isolate 6 assessed as reduction in bacterial growth incubated for 16 to 20 hrs by CLSI-based broth microdilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Synthesis and antibacterial bioactivities of cationic deacetyl linezolid amphiphiles. |
| AID533119 | Antimicrobial activity against Staphylococcus aureus 10*3d1-10 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Serial daptomycin selection generates daptomycin-nonsusceptible Staphylococcus aureus strains with a heterogeneous vancomycin-intermediate phenotype. |
| AID528726 | Antibacterial activity against Streptococcus mitis clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID1271217 | Cmax in BALB/c mouse plasma at 10 mg/kg, po by LC-MS/MS analysis | 2015 | ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11 | Design, Synthesis, and Identification of Silicon Incorporated Oxazolidinone Antibiotics with Improved Brain Exposure. |
| AID662300 | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv grown in glycerol-alanine-salts media | 2012 | Bioorganic & medicinal chemistry, Jun-01, Volume: 20, Issue:11 | Syntheses and biological studies of novel spiropiperazinyl oxazolidinone antibacterial agents using a spirocyclic diene derived acylnitroso Diels-Alder reaction. |
| AID1056337 | Inhibition of human CYP2D6 assessed as dextromethorphan O-demethylation after 20 mins by LC-MS/MS analysis | 2013 | ACS medicinal chemistry letters, Nov-14, Volume: 4, Issue:11 | Potent oxazolidinone antibacterials with heteroaromatic C-ring substructure. |
| AID573870 | Antibacterial activity against community-associated methicillin-resistant Staphylococcus aureus OC8525 infected in sc dosed Swiss Webster mouse administered at 1 to 3 hrs post infection measured after 3 days | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | In vivo activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. |
| AID1390484 | Antibacterial activity against Enterococcus faecalis ATCC 29212 | 2018 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 28, Issue:7 | Design, synthesis and biological evaluation of spiropyrimidinetriones oxazolidinone derivatives as antibacterial agents. |
| AID695450 | Inhibition of human ERG expressed in mammalian cells at 10 uM by patch clamp method | 2011 | Journal of medicinal chemistry, May-12, Volume: 54, Issue:9 | Selenophene-containing inhibitors of type IIA bacterial topoisomerases. |
| AID1591548 | Ratio of MBC for penicillin-resistant Staphylococcus aureus clinical isolate to MIC for penicillin-resistant Staphylococcus aureus clinical isolate | 2019 | Bioorganic & medicinal chemistry, 07-15, Volume: 27, Issue:14 | Discovery of 1,3,4-oxadiazol-2-one-containing benzamide derivatives targeting FtsZ as highly potent agents of killing a variety of MDR bacteria strains. |
| AID1308240 | Bacteriostatic activity against multidrug resistant Staphylococcus aureus ATCC 27660 | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10 | Structure-Activity Relationship for the 4(3H)-Quinazolinone Antibacterials. |
| AID1501357 | Antibacterial activity against methicillin-resistant Staphylococcus aureus NRS123 (USA400) after 20 hrs by broth microdilution assay | 2017 | European journal of medicinal chemistry, Oct-20, Volume: 139 | Arylthiazole antibiotics targeting intracellular methicillin-resistant Staphylococcus aureus (MRSA) that interfere with bacterial cell wall synthesis. |
| AID326500 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis UCN41 after 24 hrs by broth macrodilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Single-dose oral amoxicillin or linezolid for prophylaxis of experimental endocarditis due to vancomycin-susceptible and vancomycin-resistant Enterococcus faecalis. |
| AID1710576 | Antibacterial activity against methicillin-resistant Staphylococcus aureus NRS383 assessed as inhibition of visible bacterial growth incubated for 18 to 20 hrs by CLSI method | 2020 | RSC medicinal chemistry, Jan-01, Volume: 11, Issue:1 | Potent trifluoromethoxy, trifluoromethylsulfonyl, trifluoromethylthio and pentafluorosulfanyl containing (1,3,4-oxadiazol-2-yl)benzamides against drug-resistant Gram-positive bacteria. |
| AID206439 | In vitro antibacterial activity against linezolid-resistant Staphylococcus aureus ATCC 29213 (LRSA). | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | New antibacterial tetrahydro-4(2H)-thiopyran and thiomorpholine S-oxide and S,S-dioxide phenyloxazolidinones. |
| AID1390473 | Antibacterial activity against linezolid-resistant Staphylococcus epidermidis 1117174 | 2018 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 28, Issue:7 | Design, synthesis and biological evaluation of spiropyrimidinetriones oxazolidinone derivatives as antibacterial agents. |
| AID323807 | Reduction in bioluminescent methicillin-sensitive Staphylococcus aureus Xen29 in immunocompetent CD1 mouse with peritonitis at 100 mg/kg, po after 4 hrs relative to control | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Rapid bactericidal activity of daptomycin against methicillin-resistant and methicillin-susceptible Staphylococcus aureus peritonitis in mice as measured with bioluminescent bacteria. |
| AID1395989 | Hemolytic activity in human RBC at 200 uM after 1 hr relative to control | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9 | An Efficient Buchwald-Hartwig/Reductive Cyclization for the Scaffold Diversification of Halogenated Phenazines: Potent Antibacterial Targeting, Biofilm Eradication, and Prodrug Exploration. |
| AID533413 | Antimicrobial activity against Peptoniphilus asaccharolyticus by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activities of doripenem, a new broad-spectrum carbapenem, against recently collected clinical anaerobic isolates, with emphasis on the Bacteroides fragilis group. |
| AID576869 | Bactericidal activity against 13 hrs peripheral compartment culture samples of Enterococcus faecalis Ef1497 MutM3 in two-compartment pharmacokinetic/pharmacodynamic model assessed as effect on bacterial count at 200 mg, bid administered as 0.5 hr infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID528738 | Antibacterial activity against methicillin resistant Staphylococcus aureus clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID1393962 | Antibacterial activity against methicillin resistant Staphylococcus aureus ATCC 33591 after 16 to 20 hrs by CLSI method | 2018 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 28, Issue:16 | 3-Hydroxy-1,5-dihydro-2H-pyrrol-2-ones as novel antibacterial scaffolds against methicillin-resistant Staphylococcus aureus. |
| AID525135 | Antibacterial activity against Staphylococcus aureus KM50 after 18 to 24 hrs by broth microdilution method selected after 16 ug/ml drug exposure for 6 hrs by culture absorbance method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Delayed development of linezolid resistance in Staphylococcus aureus following exposure to low levels of antimicrobial agents. |
| AID572015 | Antibacterial activity against Prevotella P disiens by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID1151773 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus ATCC 29213 in mouse thigh infection model assessed as reduction of log10 CFU per thigh at 20 mg/kg, po | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID574949 | Antimicrobial activity against Streptococcus pneumoniae serotype 3 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID1547708 | Antibacterial activity against Staphylococcus aureus NRS120 by broth microdilution method | 2020 | ACS medicinal chemistry letters, Mar-12, Volume: 11, Issue:3 | Structure-Activity Relationship for the Oxadiazole Class of Antibacterials. |
| AID534158 | Antimicrobial activity against linezolid-resistant Staphylococcus epidermidis by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains. |
| AID734707 | Antibacterial activity against Micrococcus luteus MTCC 2470 after 24 hrs by agar dilution method | 2013 | European journal of medicinal chemistry, Apr, Volume: 62 | Synthesis, biological evaluation of new oxazolidino-sulfonamides as potential antimicrobial agents. |
| AID1710573 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus NRS 107 assessed as inhibition of visible bacterial growth incubated for 18 to 20 hrs by CLSI method | 2020 | RSC medicinal chemistry, Jan-01, Volume: 11, Issue:1 | Potent trifluoromethoxy, trifluoromethylsulfonyl, trifluoromethylthio and pentafluorosulfanyl containing (1,3,4-oxadiazol-2-yl)benzamides against drug-resistant Gram-positive bacteria. |
| AID373652 | Antimicrobial activity against panton-valentine leukocidin-positive community-acquired methicillin-resistant Staphylococcus aureus 490 by agar dilution CLSI method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID1311369 | Antibacterial activity against Mycobacterium abscessus ATCC 19977 measured after 3 days by broth microdilution assay | 2016 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15 | An evolved oxazolidinone with selective potency against Mycobacterium tuberculosis and gram positive bacteria. |
| AID285082 | Antimicrobial activity against viridans group Streptococcus bovis at 2 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID1308209 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus ATCC 29213 incubated for 16 to 20 hrs by microdilution method | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10 | Structure-Activity Relationship for the 4(3H)-Quinazolinone Antibacterials. |
| AID1594362 | Antibacterial activity against vancomycin-resistant Staphylococcus aureus VRS11a after 18 to 24 hrs by broth microdilution assay | 2019 | Bioorganic & medicinal chemistry, 05-01, Volume: 27, Issue:9 | Second-generation aryl isonitrile compounds targeting multidrug-resistant Staphylococcus aureus. |
| AID528722 | Antibacterial activity against Streptococcus viridans clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID520011 | Antimicrobial activity against Staphylococcus aureus A8831 harboring U2500A mutation in 23S rRNA | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID561079 | Antibacterial activity against vancomycin-susceptible Enterococcus faecalis by CLSI M7-A7 broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | In vitro activity of TR-700, the active ingredient of the antibacterial prodrug TR-701, a novel oxazolidinone antibacterial agent. |
| AID208756 | Antibacterial activity against Streptococcus agalactiae | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | Iclaprim, a novel diaminopyrimidine with potent activity on trimethoprim sensitive and resistant bacteria. |
| AID1329015 | Antibacterial activity against Streptococcus pneumoniae PBS1399 | 2016 | Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24 | Discovery, pharmacology, and clinical profile of omadacycline, a novel aminomethylcycline antibiotic. |
| AID1710571 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 33592 assessed as inhibition of visible bacterial growth incubated for 18 to 20 hrs by CLSI method | 2020 | RSC medicinal chemistry, Jan-01, Volume: 11, Issue:1 | Potent trifluoromethoxy, trifluoromethylsulfonyl, trifluoromethylthio and pentafluorosulfanyl containing (1,3,4-oxadiazol-2-yl)benzamides against drug-resistant Gram-positive bacteria. |
| AID209895 | Antibacterial activity against Streptococcus pneumoniae UC9912 (S.p) | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | Synthesis and biological evaluation of benzazepine oxazolidinone antibacterials. |
| AID541067 | Half life in cage fluid of Albino guiena pig at 25 mg/kg, ip | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Linezolid alone or combined with rifampin against methicillin-resistant Staphylococcus aureus in experimental foreign-body infection. |
| AID576662 | Bactericidal activity against 13 hrs peripheral compartment culture samples of Enterococcus faecalis ATCC 29212 in two-compartment pharmacokinetic/pharmacodynamic model assessed as effect on bacterial count at 600 mg, bid administered as 0.5 hr infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID369442 | Antibacterial activity against vancomycin-resistant Enterococcus faecium after 20 to 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vitro activity of telavancin against gram-positive clinical isolates recently obtained in Europe. |
| AID348864 | Antibacterial activity against vancomycin-resistant Enterococcus 5 after 18 to 20 hrs by agar dilution method | 2008 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 18, Issue:21 | Synthesis and antibacterial activities of novel oxazolidinones having cyclic sulfonamide moieties. |
| AID524946 | Antibacterial activity against methicillin-susceptible coagulase-negative Staphylococcus epidermidis clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Comparative surveillance study of telavancin activity against recently collected gram-positive clinical isolates from across the United States. |
| AID1539452 | Antibacterial activity against Staphylococcus epidermidis NRS101 after 18 to 20 hrs in aerobic condition by CLSI-based broth microdilution assay | |||
| AID695449 | Cytotoxicity against human HepG2 cell line after 72 hrs | 2011 | Journal of medicinal chemistry, May-12, Volume: 54, Issue:9 | Selenophene-containing inhibitors of type IIA bacterial topoisomerases. |
| AID429430 | Antibacterial activity against Moraxella catarrhalis by agar dilution method | 2009 | European journal of medicinal chemistry, Aug, Volume: 44, Issue:8 | Synthesis and antibacterial activity of novel 5-(4-methyl-1H-1,2,3-triazole) methyl oxazolidinones. |
| AID1547738 | Drug level in mouse thigh infected with linezolid-sensitive Staphylococcus aureus NRS70 at 40 mg/kg, po administered 1 hrs post infection and measured for 48 hrs | 2020 | ACS medicinal chemistry letters, Mar-12, Volume: 11, Issue:3 | Structure-Activity Relationship for the Oxadiazole Class of Antibacterials. |
| AID1151718 | Antibacterial activity against beta-lactamase-negative Staphylococcus | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID428275 | Antituberculosis activity against Mycobacterium tuberculosis by bactec 460 TB method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro-selected linezolid-resistant Mycobacterium tuberculosis mutants. |
| AID571794 | Antibacterial activity against Clostridium perfringens by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID1151749 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus ATCC 29213 | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID522892 | Antibacterial activity against vancomycin-intermediate Staphylococcus aureus isolate 1009 after 24 hrs by modified broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Antistaphylococcal activity of ACHN-490 tested alone and in combination with other agents by time-kill assay. |
| AID523050 | Antimicrobial activity against ampicillin-nonsusceptible beta-lactamase negative Haemophilus influenzae by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative in vitro antimicrobial activities of torezolid (TR-700), the active moiety of a new oxazolidinone, torezolid phosphate (TR-701), determination of tentative disk diffusion interpretive criteria, and quality control ranges. |
| AID1151779 | Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate 0605 in mouse thigh infection model assessed as reduction of log10 CFU per thigh at 40 mg/kg, po | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID1703724 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis ATCC 51299 assessed as inhibition of bacterial growth measured after 18 to 20 hrs by CLSI protocol based broth microdilution method | 2020 | European journal of medicinal chemistry, Sep-15, Volume: 202 | Evaluation of N-phenyl-2-aminothiazoles for treatment of multi-drug resistant and intracellular Staphylococcus aureus infections. |
| AID572016 | Antibacterial activity against Prevotella P intermedia by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID1390489 | Antibacterial activity against vancomycin-resistant Enterococcus faecium 31/132 | 2018 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 28, Issue:7 | Design, synthesis and biological evaluation of spiropyrimidinetriones oxazolidinone derivatives as antibacterial agents. |
| AID1311359 | Antibacterial activity against Acinetobacter baumannii ATCC 19606 measured after 18 hrs by broth microdilution assay | 2016 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15 | An evolved oxazolidinone with selective potency against Mycobacterium tuberculosis and gram positive bacteria. |
| AID1327116 | Antibacterial activity against Bacillus subtilis NCIM 2010 at 3 ug/ml measured after 12 hrs by spectrophotometric method | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Design, synthesis and biological evaluation of novel azaspiro analogs of linezolid as antibacterial and antitubercular agents. |
| AID363435 | Antibacterial activity against Streptococcus pneumoniae ATCC 6303-infeceted Sprague-Dawley rat assessed as reduction in lung bacterial density at 25 mg/kg, po administered twice at 18 and 26 hrs after bacterial challenge measured at 72 hrs postinfection | 2008 | Journal of medicinal chemistry, Sep-11, Volume: 51, Issue:17 | Novel dual-targeting benzimidazole urea inhibitors of DNA gyrase and topoisomerase IV possessing potent antibacterial activity: intelligent design and evolution through the judicious use of structure-guided design and structure-activity relationships. |
| AID1852686 | Antibacterial activity against efflux pump lacking Pseudomonas aeruginosa assessed as inhibition of bacterial growth | |||
| AID575041 | AUC (24 hrs) in patient plasma at 600 mg, iv or 600 mg, po administered every 12 hrs by HPLC | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Therapeutic drug monitoring of linezolid: a retrospective monocentric analysis. |
| AID1374166 | Antibacterial activity against Escherichia coli ATCC 25922 incubated at 37 degC for 20 hrs by standard broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4 | Design, synthesis and antibacterial evaluation of honokiol derivatives. |
| AID548528 | Antimicrobial activity against Oxacillin-resistant coagulase-negative Staphylococcus by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Activities of dalbavancin against a worldwide collection of 81,673 gram-positive bacterial isolates. |
| AID429419 | Antibacterial activity against methicillin-resistant Staphylococcus aureus by agar dilution method | 2009 | European journal of medicinal chemistry, Aug, Volume: 44, Issue:8 | Synthesis and antibacterial activity of novel 5-(4-methyl-1H-1,2,3-triazole) methyl oxazolidinones. |
| AID528733 | Antibacterial activity against methicillin resistant coagulase-negative Staphylococcus hominis subsp. novobiosepticus clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID1591544 | Antibacterial activity against Escherichia coli ATCC 25922 incubated for 24 hrs by CLSI protocol based broth microdilution method | 2019 | Bioorganic & medicinal chemistry, 07-15, Volume: 27, Issue:14 | Discovery of 1,3,4-oxadiazol-2-one-containing benzamide derivatives targeting FtsZ as highly potent agents of killing a variety of MDR bacteria strains. |
| AID326298 | Antibacterial activity against methicillin-resistant Staphylococcus aureus 293 at 4 hrs daily exposure for 5 days by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Comparative activities of daptomycin, linezolid, and tigecycline against catheter-related methicillin-resistant Staphylococcus bacteremic isolates embedded in biofilm. |
| AID745377 | Inhibition of human CYP1A2 assessed as ethoxyresorufin O-deethylation after 20 mins by fluorescence plate reader analysis | 2013 | European journal of medicinal chemistry, May, Volume: 63 | Antibacterial oxazolidinone analogues having a N-hydroxyacetyl-substituted seven-membered [1,2,5]triazepane or [1,2,5]oxadiazepane C-ring unit. |
| AID1151705 | Antibacterial activity against Staphylococcus aureus | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID349316 | Antibacterial activity against vancomycin-sensitive Enterococcus after 18 hrs by agar dilution method | 2008 | European journal of medicinal chemistry, May, Volume: 43, Issue:5 | Synthesis and structure-antibacterial activity of triazolyl oxazolidinones containing long chain acyl moiety. |
| AID559366 | Antimicrobial activity against compound-susceptible Coxiella burnetii isolate CP1 obtained from patient with acute Q fever infected in african green monkey Vero cells after 24 hrs by shell vial assay | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Bacteriostatic and bactericidal activities of tigecycline against Coxiella burnetii and comparison with those of six other antibiotics. |
| AID572273 | Antimicrobial activity against Streptococcus pneumoniae ATCC 6303 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vivo characterization of the peptide deformylase inhibitor LBM415 in murine infection models. |
| AID125097 | Minimum inhibitory concentration measured against Moraxella catarrhalis | 2002 | Bioorganic & medicinal chemistry letters, Aug-19, Volume: 12, Issue:16 | The synthesis and biological evaluation of a novel series of antimicrobials of the oxazolidinone class. |
| AID278906 | Antibacterial activity against Staphylococcus aureus | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | In vitro antibacterial activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. |
| AID308486 | Antibacterial activity against Staphylococcus aureus UC76 SA1 | 2007 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 17, Issue:16 | Synthesis and SAR of novel conformationally restricted oxazolidinones possessing gram-positive and fastidious gram-negative antibacterial activity. Part 2: Amino substitutions on heterocyclic D-ring system. |
| AID1770364 | Bactericidal activity against Vancomycin-susceptible Enterococcus faecalis ATCC 29212 assessed as inhibition of bacterial growth measured after 20 hrs by two-fold microdilution assay | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Modification of 5-methylphenanthridium from benzothiazoles to indoles as potent FtsZ inhibitors: Broadening the antibacterial spectrum toward vancomycin-resistant enterococci. |
| AID370009 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus Smith infected in C3H mouse assessed as eradication at 6.25 mg/kg/day, po administered within 15 mins of infection assessed per gram of kidney measured after 48 hrs by organ burd | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vivo efficacy of a novel oxazolidinone compound in two mouse models of infection. |
| AID410113 | Antimicrobial activity against erm (B) expressing Streptococcus pneumoniae 02J1258 + L4 by NCCLS method | 2008 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 18, Issue:23 | Design at the atomic level: design of biaryloxazolidinones as potent orally active antibiotics. |
| AID477370 | Antibacterial activity against floxacin and methicillin-resistant Staphylococcus aureus ATCC 25923 after 24 hrs | 2009 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13 | Synthesis and antibacterial evaluation of isoxazolinyl oxazolidinones: Search for potent antibacterial. |
| AID285021 | Antimicrobial activity against Listeria monocytogenes at 0.25 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID561097 | Antibacterial activity against Porphyromonas asaccharolytica by CLSI M11-A7 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | In vitro activity of TR-700, the active ingredient of the antibacterial prodrug TR-701, a novel oxazolidinone antibacterial agent. |
| AID1862422 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis ATCC 51575 assessed as reduction in visible bacterial growth incubated for 18 to 20 hrs by CLSI based broth microdilution analysis | 2022 | European journal of medicinal chemistry, Oct-05, Volume: 240 | Membrane acting Povarov-Doebner derived compounds potently disperse preformed multidrug resistant Gram-positive bacterial biofilms. |
| AID525136 | Antibacterial activity against Staphylococcus aureus KB103 after 18 to 24 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Delayed development of linezolid resistance in Staphylococcus aureus following exposure to low levels of antimicrobial agents. |
| AID283400 | Antimicrobial activity against Nocardia sp. after 72 hrs by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | In vitro activities of tigecycline and eight other antimicrobials against different Nocardia species identified by molecular methods. |
| AID555300 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus ATCC 29213 by broth macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Antistaphylococcal activity of dihydrophthalazine antifolates, a family of novel antibacterial drugs. |
| AID1076824 | Antitubercular activity against isoniazid-resistant Mycobacterium tuberculosis H37RV clinical isolate 1 assessed as growth inhibition by microdilution method | 2014 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 24, Issue:6 | Discovery of novel bis-oxazolidinone compounds as potential potent and selective antitubercular agents. |
| AID528695 | Antibacterial activity against methicillin resistant Staphylococcus aureus MED 1805 bloodstream isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID1167728 | Inhibition of Escherichia coli DNA gyrase using fluorescence-tagged DNA by fluorescenct polarization assay | 2014 | Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21 | Novel DNA gyrase inhibiting spiropyrimidinetriones with a benzisoxazole scaffold: SAR and in vivo characterization. |
| AID533425 | Antimicrobial activity against Peptostreptococcus sp. by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activities of doripenem, a new broad-spectrum carbapenem, against recently collected clinical anaerobic isolates, with emphasis on the Bacteroides fragilis group. |
| AID370041 | Antibacterial activity against 10'9 CFU linezolid-resistant methicillin-resistant Staphylococcus aureus by dilution susceptibility test | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vivo efficacy of a novel oxazolidinone compound in two mouse models of infection. |
| AID285017 | Antimicrobial activity against Enterococcus raffinosus at 1 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID284994 | Antimicrobial activity against Enterococcus durans at <= 0.06 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID1308232 | Antibacterial activity against Streptococcus pyogenes ATCC 49399 incubated for 16 to 20 hrs by microdilution method | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10 | Structure-Activity Relationship for the 4(3H)-Quinazolinone Antibacterials. |
| AID585167 | Antibacterial activity against Mycobacterium smegmatis harboring 23S rRNA G2032A, C2499A mutant after 24 generation times | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Mutations in 23S rRNA at the peptidyl transferase center and their relationship to linezolid binding and cross-resistance. |
| AID1193403 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 measured after overnight incubation | 2015 | Bioorganic & medicinal chemistry, Apr-01, Volume: 23, Issue:7 | Identification of Bacillus anthracis PurE inhibitors with antimicrobial activity. |
| AID1649280 | Antibacterial activity against Staphylococcus aureus RN4220 assessed as inhibition of bacterial growth incubated for 20 hrs by microdilution broth method | |||
| AID776671 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 after 16 to 20 hrs by microdilution method | 2013 | European journal of medicinal chemistry, Nov, Volume: 69 | Novel promising linezolid analogues: rational design, synthesis and biological evaluation. |
| AID564805 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus after 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID745406 | Antibacterial activity against Staphylococcus aureus Smith assessed as growth inhibition by CLSI broth microdilution method | 2013 | European journal of medicinal chemistry, May, Volume: 63 | Antibacterial oxazolidinone analogues having a N-hydroxyacetyl-substituted seven-membered [1,2,5]triazepane or [1,2,5]oxadiazepane C-ring unit. |
| AID303913 | Antibacterial activity against methicillin-resistant Staphylococcus aureus 33 after 24 hrs by agar dilution method | 2007 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 17, Issue:24 | Synthesis and antibacterial activity of potent heterocyclic oxazolidinones and the identification of RBx 8700. |
| AID283629 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus Ho 4280-0257 with heterozygous 23S rRNA G2576U mutation | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | In vitro activity of the oxazolidinone RWJ-416457 against linezolid-resistant and -susceptible staphylococci and enterococci. |
| AID439894 | Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate 1 after 18 hrs by agar dilution method | 2010 | European journal of medicinal chemistry, Jan, Volume: 45, Issue:1 | Synthesis and antibacterial activity of isothiazolyl oxazolidinones and analogous 3(2H)-isothiazolones. |
| AID85783 | Antibacterial activity against Haemophillia influenzae | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | Iclaprim, a novel diaminopyrimidine with potent activity on trimethoprim sensitive and resistant bacteria. |
| AID1539447 | Antibacterial activity against Methicillin-resistant Staphylococcus aureus NRS385-USA500 clinical isolates after 18 to 20 hrs in aerobic condition by CLSI protocol based broth microdilution assay | |||
| AID581663 | Antibacterial activity against Staphylococcus aureus SCV isolated from cystic fibrosis patient infected in human THP-1 cells assessed as log reduction of intracellular CFU level per mg of protein at up to 10'5 times MIC after 24 hrs | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Intracellular activity of antibiotics in a model of human THP-1 macrophages infected by a Staphylococcus aureus small-colony variant strain isolated from a cystic fibrosis patient: pharmacodynamic evaluation and comparison with isogenic normal-phenotype a |
| AID285052 | Antimicrobial activity against Rothia mucilaginosa by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID1327101 | Antitubercular activity against active stage Mycobacterium tuberculosis H37Ra measured after 8 days by XTT assay | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Design, synthesis and biological evaluation of novel azaspiro analogs of linezolid as antibacterial and antitubercular agents. |
| AID1400059 | Antibacterial activity against Streptococcus salivarius ATCC 6301 incubated for 24 hrs under aerobic condition by MABA | 2018 | Bioorganic & medicinal chemistry, 09-15, Volume: 26, Issue:17 | An antimycobacterial pleuromutilin analogue effective against dormant bacilli. |
| AID1861526 | Cmax in Wistar rat at 30 mg/kg, iv | 2022 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 71 | WCK 4034: A promising oxazolidinone for treating gram positive infections. |
| AID285067 | Antimicrobial activity against beta hemolytic Streptococci group G at 0.25 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID428278 | Antituberculosis activity against linezolid-resistant Mycobacterium tuberculosis by bactec MGIT 960 method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro-selected linezolid-resistant Mycobacterium tuberculosis mutants. |
| AID562636 | Antimicrobial activity against Listeria monocytogenes by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | In vitro activities of three new dihydrofolate reductase inhibitors against clinical isolates of gram-positive bacteria. |
| AID1390464 | Antibacterial activity against methicillin-resistant Staphylococcus aureus 562 | 2018 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 28, Issue:7 | Design, synthesis and biological evaluation of spiropyrimidinetriones oxazolidinone derivatives as antibacterial agents. |
| AID1594357 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus NRS107 after 18 to 24 hrs by broth microdilution assay | 2019 | Bioorganic & medicinal chemistry, 05-01, Volume: 27, Issue:9 | Second-generation aryl isonitrile compounds targeting multidrug-resistant Staphylococcus aureus. |
| AID326294 | Antibacterial activity against methicillin-resistant Staphylococcus aureus 5004 at 4 hrs daily exposure for 5 days by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Comparative activities of daptomycin, linezolid, and tigecycline against catheter-related methicillin-resistant Staphylococcus bacteremic isolates embedded in biofilm. |
| AID561253 | Antibacterial activity against Streptococcus pyogenes by CLSI M100-S17 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | AFN-1252, a FabI inhibitor, demonstrates a Staphylococcus-specific spectrum of activity. |
| AID529823 | Bactericidal activity against community-acquired methicillin-resistant Staphylococcus aureus by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Activities of ceftobiprole, linezolid, vancomycin, and daptomycin against community-associated and hospital-associated methicillin-resistant Staphylococcus aureus. |
| AID1329018 | Antibacterial activity against Streptococcus pneumoniae PBS1399 infected in mouse assessed as protection against bacterial infection by measuring mouse survival administered intravenously as single dose after 2 hrs of infection measured on day 7 | 2016 | Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24 | Discovery, pharmacology, and clinical profile of omadacycline, a novel aminomethylcycline antibiotic. |
| AID561515 | Antibacterial activity against Enterococcus faecium by CLSI broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Potency and bactericidal activity of iclaprim against recent clinical gram-positive isolates. |
| AID573156 | Antibacterial activity against vancomycin-resistant Enterococcus faecium assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID278909 | Antibacterial activity against vancomycin-intermediate methicillin-resistant Staphylococcus aureus | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | In vitro antibacterial activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. |
| AID285343 | Antibacterial activity against community acquired methicillin-resistant Staphylococcus aureus HT20030203 in Mueller-Hinton medium | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Effect of antibiotics on Staphylococcus aureus producing Panton-Valentine leukocidin. |
| AID1414209 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 infected in mouse assessed as reduction of bacterial burden in blood at 30 mg/kg, ip administered 0.1, 6 hrs postinfection and measured at 24 hrs post last dose | 2018 | European journal of medicinal chemistry, Nov-05, Volume: 159 | Design, synthesis and structure-based optimization of novel isoxazole-containing benzamide derivatives as FtsZ modulators. |
| AID370006 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus Smith infected in C3H mouse assessed as mortality at 3.12 mg/kg/day, po administered within 15 mins of infection measured after 48 hrs by organ burden assay relative to control | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vivo efficacy of a novel oxazolidinone compound in two mouse models of infection. |
| AID207681 | Minimum inhibitory concentration (MIC) against Staphylococcus aureus OC 4172 in the presence of 50% mouse serum | 2004 | Bioorganic & medicinal chemistry letters, Jun-21, Volume: 14, Issue:12 | The synthesis and antimicrobial evaluation of a new series of isoxazolinyl oxazolidinones. |
| AID499113 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus Smith OC 4172 infected immunocompromized SKH1 mouse assessed as lesion volume at 100 mg/kg/day, sc measured after 48 hrs postinfection (Rvb = 1181 mm3) | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vivo activity of ceftobiprole in murine skin infections due to Staphylococcus aureus and Pseudomonas aeruginosa. |
| AID1361111 | Bactericidal activity against methicillin-resistant Staphylococcus aureus USA800 NRS387 clinical isolate preincubated for 20 hrs followed by TSA plating and measured after 18 hrs | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | N-(1,3,4-oxadiazol-2-yl)benzamide analogs, bacteriostatic agents against methicillin- and vancomycin-resistant bacteria. |
| AID1079939 | Cirrhosis, proven histopathologically. Value is number of references indexed. [column 'CIRRH' in source] | |||
| AID373992 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus 525 after 50 passages with vancomycin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID522924 | Antibacterial activity against community-acquired methicillin-resistant panton-valentine leukocidin-positive Staphylococcus aureus isolate 593 after 24 hrs by modified broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Antistaphylococcal activity of ACHN-490 tested alone and in combination with other agents by time-kill assay. |
| AID245440 | Minimum inhibitory concentration against penicillin-susceptible Streptococcus pneumoniae UC9912; Range is 0.5-1 ug/mL | 2005 | Journal of medicinal chemistry, Jul-28, Volume: 48, Issue:15 | Conformational constraint in oxazolidinone antibacterials. Synthesis and structure-activity studies of (azabicyclo[3.1.0]hexylphenyl)oxazolidinones. |
| AID1415069 | Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate 5 after 16 hrs by agar dilution method | 2018 | Journal of medicinal chemistry, 12-27, Volume: 61, Issue:24 | Semisynthesis of Platensimycin Derivatives with Antibiotic Activities in Mice via Suzuki-Miyaura Cross-Coupling Reactions. |
| AID1778655 | Antibacterial activity against erythromycin-resistant Streptococcus pyogenes 2 assessed as bacterial growth inhibition incubated for 24 hrs by CLSI protocol based broth microdilution method | 2021 | European journal of medicinal chemistry, Oct-05, Volume: 221 | Design, synthesis and evaluation of novel 9-arylalkyl-10-methylacridinium derivatives as highly potent FtsZ-targeting antibacterial agents. |
| AID1609283 | Antibacterial activity against methicilline-resistant Staphylococcus aureus NRS385 USA500 after 18 to 20 hrs by CLSI-based broth microdilution assay | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Phenylthiazoles with nitrogenous side chain: An approach to overcome molecular obesity. |
| AID237336 | Calculated partition coefficient (clogP) | 2004 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 14, Issue:22 | Aryl urea analogs with broad-spectrum antibacterial activity. |
| AID274229 | Antibacterial activity against Moraxella catarrhalis BC-3531 | 2006 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 16, Issue:20 | Synthesis and structure-activity studies of novel benzocycloheptanone oxazolidinone antibacterial agents. |
| AID533982 | Bacteriostatic activity against linezolid-susceptible Staphylococcus aureus ATCC 25923 infected in THP1 cells after 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Cellular pharmacodynamics of the novel biaryloxazolidinone radezolid: studies with infected phagocytic and nonphagocytic cells, using Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Legionella pneumophila. |
| AID562628 | Antimicrobial activity against Group C Streptococcus by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | In vitro activities of three new dihydrofolate reductase inhibitors against clinical isolates of gram-positive bacteria. |
| AID1435931 | Bactericidal activity against methicillin/ciprofloxacin/clindamycin-resistant Staphylococcus aureus USA100 NRS382 clinical isolate after 24 hrs | 2017 | European journal of medicinal chemistry, Jan-27, Volume: 126 | Phenylthiazole antibiotics: A metabolism-guided approach to overcome short duration of action. |
| AID1308264 | Drug level in plasma of ICR mouse neutropenic thigh model of methicillin-resistant Staphylococcus aureus NRS70 infection at 10 mg/kg, sc tid administered every 8 hrs starting from 1 hr post infection and measured 7 hrs post last dose by UPLC analysis | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10 | Structure-Activity Relationship for the 4(3H)-Quinazolinone Antibacterials. |
| AID1151732 | Antibacterial activity against Streptococcus sanguinis | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID1609282 | Antibacterial activity against vancomycin-resistant Staphylococcus aureus 10 after 18 to 20 hrs by CLSI-based broth microdilution assay | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Phenylthiazoles with nitrogenous side chain: An approach to overcome molecular obesity. |
| AID297958 | AUC in Streptococcus pneumoniae 548 infected mouse lung infection model at 80 mg/kg/day, po | 2007 | Journal of medicinal chemistry, Oct-04, Volume: 50, Issue:20 | Novel substituted (pyridin-3-yl)phenyloxazolidinones: antibacterial agents with reduced activity against monoamine oxidase A and increased solubility. |
| AID583409 | Antimicrobial activity against vancomycin-resistant Staphylococcus aureus isolate PA assessed as bacterial count at 16 times MIC after 24 hrs by colony counting method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | In vitro activity of the new multivalent glycopeptide-cephalosporin antibiotic TD-1792 against vancomycin-nonsusceptible Staphylococcus isolates. |
| AID528717 | Antibacterial activity against methicillin resistant Staphylococcus aureus clinical isolate assessed as susceptibility level by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID542903 | Antimicrobial activity against Bacillus anthracis infected in in vitro hollow fiber PK/PD model assessed as bacterial regrowth at 200 mg administered once every 24 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID1151751 | Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate 0605 | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID542702 | fCmax in Bacillus anthracis infected in vitro hollow fiber PK/PD model at simulated dose of 800 mg /day administered once every 24 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID326505 | Cmax in Enterococcus faecalis infected Wistar rat at 600 mg, po two consecutive administration every 12 hrs | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Single-dose oral amoxicillin or linezolid for prophylaxis of experimental endocarditis due to vancomycin-susceptible and vancomycin-resistant Enterococcus faecalis. |
| AID383568 | Antibacterial activity against linezolid-resistant Staphylococcus aureus NRS 119 with G 2576T mutation by broth microdilution technique | 2008 | European journal of medicinal chemistry, Apr, Volume: 43, Issue:4 | Synthesis and in vitro antibacterial activities of novel oxazolidinones. |
| AID278929 | Antibacterial activity against Chlamydophila pneumoniae in HEp2 cells | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | In vitro antibacterial activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. |
| AID524979 | Antibacterial activity against Streptococcus intermedius clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Comparative surveillance study of telavancin activity against recently collected gram-positive clinical isolates from across the United States. |
| AID542699 | fCmax in Bacillus anthracis infected in vitro hollow fiber PK/PD model at simulated dose of 600 mg /day | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID555737 | Antibacterial activity against methicillin-resistant and vancomycin-resistant Staphylococcus aureus VRS1 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Antistaphylococcal activity of dihydrophthalazine antifolates, a family of novel antibacterial drugs. |
| AID205679 | Minimum inhibitory concentration against Staphylococcus aureus MTCC 96 | 2004 | Bioorganic & medicinal chemistry letters, Jun-21, Volume: 14, Issue:12 | Oxazolidinone: search for highly potent antibacterial. |
| AID285056 | Antimicrobial activity against beta hemolytic Streptococcus group C at 0.5 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID542715 | fT>MIC in Bacillus anthracis infected in vitro hollow fiber PK/PD model at simulated dose of 600 mg /day administered as 6 divided doses every 4 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID1427354 | Antibacterial activity against methicillin-resistant Staphylococcus aureus RKI 11-02670 after 18 hrs | 2017 | Bioorganic & medicinal chemistry, 03-15, Volume: 25, Issue:6 | New nitrofurans amenable by isocyanide multicomponent chemistry are active against multidrug-resistant and poly-resistant Mycobacterium tuberculosis. |
| AID1151754 | Antibacterial activity against penicillin-sensitive Streptococcus pneumoniae isolate 0806 | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID323823 | Reduction in bioluminescent methicillin-sensitive Staphylococcus aureus Xen29 in neutropenic CD1 mouse with peritonitis at 100 mg/kg, po after 5 hrs relative to control | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Rapid bactericidal activity of daptomycin against methicillin-resistant and methicillin-susceptible Staphylococcus aureus peritonitis in mice as measured with bioluminescent bacteria. |
| AID520772 | Toxicity in methicillin-resistant Staphylococcus aureus-infected New Zealand rabbit osteomyelitis model assessed as body weight at 60 mg/kg, po administered every 8 hrs for 4 days measured on week 4 postinfection (Rvb = 2.43 +/- 0.15 kg) | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Efficacies of ceftobiprole medocaril and comparators in a rabbit model of osteomyelitis due to methicillin-resistant Staphylococcus aureus. |
| AID520009 | Antimicrobial activity against Staphylococcus aureus A7819 harboring G2576U mutation in 23S rRNA | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID558515 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus 540 measured on day 25 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID565228 | Antimicrobial activity against Mycobacterium chelonae ATCC 35752 by resazurine microtiter assay | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Role of porins in the susceptibility of Mycobacterium smegmatis and Mycobacterium chelonae to aldehyde-based disinfectants and drugs. |
| AID573138 | Antibacterial activity against erythromycin-susceptible Streptococcus agalactiae by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID576427 | Antibacterial activity against Enterococcus faecalis ATCC 29212 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID285326 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus ATCC 43300 | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | In vitro activity of aurein 1.2 alone and in combination with antibiotics against gram-positive nosocomial cocci. |
| AID1390463 | Antibacterial activity against Staphylococcus aureus FDA 209P | 2018 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 28, Issue:7 | Design, synthesis and biological evaluation of spiropyrimidinetriones oxazolidinone derivatives as antibacterial agents. |
| AID541549 | Antimicrobial activity against penicillin-intermediate Streptococcus pneumoniae clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID373311 | Antibacterial activity against Haemophilus influenzae clinical isolate after 18 hrs by NCCLS M7-A4 method | 2009 | European journal of medicinal chemistry, Mar, Volume: 44, Issue:3 | Synthesis, antibacterial and anticonvulsant evaluations of some cyclic enaminones. |
| AID517669 | Antimicrobial activity against Enterococcus faecium NCTC 12201 by standard serial-dilution technique | 2010 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 20, Issue:20 | Bottromycin derivatives: efficient chemical modifications of the ester moiety and evaluation of anti-MRSA and anti-VRE activities. |
| AID303971 | Antibacterial activity against Staphylococcus aureus UC76 in po dosed CD1 mouse systemic infection model assessed as mortality after 7 days | 2007 | Journal of medicinal chemistry, Nov-29, Volume: 50, Issue:24 | Antibacterial oxazolidinones possessing a novel C-5 side chain. (5R)-trans-3-[3-Fluoro-4- (1-oxotetrahydrothiopyran-4-yl)phenyl]-2- oxooxazolidine-5-carboxylic acid amide (PF-00422602), a new lead compound. |
| AID511396 | Antibacterial activity against Streptococcus viridans by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Comparative in vitro activities of nemonoxacin (TG-873870), a novel nonfluorinated quinolone, and other quinolones against clinical isolates. |
| AID520004 | Antimicrobial activity against Ureaplasma urealyticum isolated from human respiratory tract by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID535008 | Antimicrobial activity against daptomycin-nonsusceptible Staphylococcus aureus by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | In vitro activity of ceftaroline against community-associated methicillin-resistant, vancomycin-intermediate, vancomycin-resistant, and daptomycin-nonsusceptible Staphylococcus aureus isolates. |
| AID562249 | Antibacterial activity against Staphylococcus aureus NARSA NRS127 harboring rplC T433 to T435 and L3 Ser145 deletion mutant by CLSI broth microdilution assay | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Mutations in ribosomal protein L3 are associated with oxazolidinone resistance in staphylococci of clinical origin. |
| AID495879 | Antibacterial activity against methicillin-resistant Staphylococcus aureus COL infected New Zealand White rabbit aortic valve endocarditis model assessed as decrease in bacterial colony forming unit in spleen at 75 mg/kg, sc dosed every 8 hrs for 4 days ( | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Ceftobiprole is superior to vancomycin, daptomycin, and linezolid for treatment of experimental endocarditis in rabbits caused by methicillin-resistant Staphylococcus aureus. |
| AID285100 | Antimicrobial activity against viridans group Streptococcus mitis at <= 0.06 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID1676981 | Antimicrobial activity against Escherichia coli JW55031 harboring TolC mutant assessed as reduction in microbial growth after 48 hrs by CLSI based broth microdilution method | |||
| AID499167 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus OC 8525 infected in SKH1 mouse assessed as log change in bacterial colony forming unit per gram of skin tissue at 25 mg/kg/day, po (Rvb = 0.8 deltalog CFU) | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vivo activity of ceftobiprole in murine skin infections due to Staphylococcus aureus and Pseudomonas aeruginosa. |
| AID541525 | Antimicrobial activity against methicillin-susceptible Staphylococcus epidermidis clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID576645 | Bactericidal activity against 14 hrs peripheral compartment culture samples of Staphylococcus aureus RN4220 MutS2 in two-compartment pharmacokinetic/pharmacodynamic model assessed as effect on bacterial count at 600 mg, bid administered as 0.5 hr infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID531569 | Antibacterial activity against Streptococcus sp. 'group C' obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID542714 | fT>MIC in Bacillus anthracis infected in vitro hollow fiber PK/PD model at simulated dose of 600 mg /day administered as 2 divided doses every 12 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID1151630 | Toxicity in female rat assessed as effect on reticulocyte count at 100 mg/kg/day, po bid administered for 4 weeks (Rvb = 1.48%) | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID561089 | Antibacterial activity against Moraxella catarrhalis by CLSI M7-A7 broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | In vitro activity of TR-700, the active ingredient of the antibacterial prodrug TR-701, a novel oxazolidinone antibacterial agent. |
| AID533020 | Antibacterial activity against vancomycin-susceptible Staphylococcus aureus N315-LR5-P1-2 assessed as inhibition of bacterial growth in brain heart infusion broth medium | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Improved antimicrobial activity of linezolid against vancomycin-intermediate Staphylococcus aureus. |
| AID285053 | Antimicrobial activity against beta hemolytic Streptococcus group C at <= 0.06 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID542707 | fAUC (24 hrs) in Bacillus anthracis infected in vitro hollow fiber PK/PD model at simulated dose of 600 mg /day administered as 2 divided doses every 12 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID729219 | Antibacterial activity against Staphylococcus aureus ATCC 29213 after 16 hrs by NCCLS agar dilution method | 2013 | Journal of medicinal chemistry, Mar-28, Volume: 56, Issue:6 | Solubility-driven optimization of (pyridin-3-yl) benzoxazinyl-oxazolidinones leading to a promising antibacterial agent. |
| AID561075 | Antibacterial activity against methicillin-resistant Staphylococcus aureus by CLSI M7-A7 broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | In vitro activity of TR-700, the active ingredient of the antibacterial prodrug TR-701, a novel oxazolidinone antibacterial agent. |
| AID555306 | Antibacterial activity against methicillin-susceptible coagulase-negative Staphylococcus epidermidis 051 by broth macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Antistaphylococcal activity of dihydrophthalazine antifolates, a family of novel antibacterial drugs. |
| AID1596547 | Antibacterial activity against vancomycin resistant Staphylococcus aureus VRS10 assessed as reduction in bacterial cell growth incubated for 18 to 20 hrs by broth microdilution method | 2019 | European journal of medicinal chemistry, Aug-01, Volume: 175 | Lipophilic efficient phenylthiazoles with potent undecaprenyl pyrophosphatase inhibitory activity. |
| AID1853455 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis ATCC 700221 assessed as bacterial growth inhibition incubated for 18 to 20 hrs by CLSI based broth microdilution assay | 2021 | RSC medicinal chemistry, Nov-17, Volume: 12, Issue:11 | SF |
| AID370024 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus Smith infected in C3H mouse assessed as reduction in log number of CFU at 12.5 mg/kg/day, iv administered within 15 mins of infection measured after 48 hrs by organ burden assay | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vivo efficacy of a novel oxazolidinone compound in two mouse models of infection. |
| AID283156 | Antimicrobial susceptibility of Staphylococcus lugdunensis IDRL2394 biofilms after 24 hrs assessed as bacterial regrowth | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | In vitro effects of antimicrobial agents on planktonic and biofilm forms of Staphylococcus lugdunensis clinical isolates. |
| AID1395987 | Bactericidal activity against vancomycin-resistant Enterococcus faecium ATCC 700221 planktonic cells after 24 hrs by calgary biofilm device method | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9 | An Efficient Buchwald-Hartwig/Reductive Cyclization for the Scaffold Diversification of Halogenated Phenazines: Potent Antibacterial Targeting, Biofilm Eradication, and Prodrug Exploration. |
| AID390322 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus 43300 | 2008 | Journal of natural products, Dec, Volume: 71, Issue:12 | Citreamicins with potent gram-positive activity. |
| AID511435 | Antimicrobial activity against Streptococcus pneumoniae | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Resistance to linezolid in a porcine Clostridium perfringens strain carrying a mutation in the rplD gene encoding the ribosomal protein L4. |
| AID533018 | Antibacterial activity against vancomycin-susceptible Staphylococcus aureus N315-LR5-P1-1 assessed as inhibition of bacterial growth in brain heart infusion broth medium | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Improved antimicrobial activity of linezolid against vancomycin-intermediate Staphylococcus aureus. |
| AID1868233 | Antibacterial activity against Enterococcus faecium ATCC BAA-2317 assessed as inhibition of bacterial growth | |||
| AID576424 | Antibacterial activity against Enterococcus faecalis Ef1497 MutM3 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID541805 | Antimicrobial activity against Enterococcus casseliflavus clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID545603 | Bacteriostatic activity against stationary-phase vancomycin-resistant Staphylococcus aureus isolate VRS5 grown on nutrient-depleted CAMHB medium at 8 ug/ml after 24 hrs by time kill analysis | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Oritavancin kills stationary-phase and biofilm Staphylococcus aureus cells in vitro. |
| AID370035 | Antibacterial activity against methicillin-resistant Staphylococcus aureus COL infected in po dosed DBA/2 mouse localized infection model assessed as log reduction in CFU per gram of thigh at 5 mg/kg, po administered 2 hrs postinfection thrice daily for 1 | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vivo efficacy of a novel oxazolidinone compound in two mouse models of infection. |
| AID559285 | Antimicrobial activity against recombination-deficient Enterococcus faecalis JH2-2 recA harboring nucleotides at position 2576 in rrlA 2576G, rrlB 2576G, rrlC 2576G and rrlD 2576T after 5 passages under Linezolid selective pressure by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Influence of recombination on development of mutational resistance to linezolid in Enterococcus faecalis JH2-2. |
| AID558486 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus 543 measured on day 10 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID520732 | Antimicrobial activity against Staphylococcus aureus RN4220 harboring plasmid LI50 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Transcriptional and translational control of the mlr operon, which confers resistance to seven classes of protein synthesis inhibitors. |
| AID533945 | Antimicrobial activity against Linezolid resistant hospital acquired methicillin-resistant Staphylococcus aureus SA238L after 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Cellular pharmacodynamics of the novel biaryloxazolidinone radezolid: studies with infected phagocytic and nonphagocytic cells, using Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Legionella pneumophila. |
| AID1409843 | Antibacterial activity against Staphylococcus aureus Newman infected in BALB/c mouse assessed as reduction of bacterial burden in heart at 0.1 mg, ip bid for 3.5 days administered 6 hrs post bacterial infection measured 84 hrs post infection relative to c | 2018 | ACS medicinal chemistry letters, Mar-08, Volume: 9, Issue:3 | Novel Staphyloxanthin Inhibitors with Improved Potency against Multidrug Resistant |
| AID67752 | Minimum inhibitory concentration against Enterococcus faecalis ATCC 14506 | 2004 | Bioorganic & medicinal chemistry letters, Jun-21, Volume: 14, Issue:12 | Oxazolidinone: search for highly potent antibacterial. |
| AID278925 | Antibacterial activity against Haemophilus influenzae | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | In vitro antibacterial activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. |
| AID522914 | Antibacterial activity against hospital-acquired methicillin-resistant Staphylococcus aureus isolate 1808 after 24 hrs by modified broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Antistaphylococcal activity of ACHN-490 tested alone and in combination with other agents by time-kill assay. |
| AID1684999 | Antibacterial activity against Staphylococcus aureus ATCC 25923 assessed as inhibition of bacterial growth incubated for 16 to 20 hrs by microdilution method | 2021 | ACS medicinal chemistry letters, Jan-14, Volume: 12, Issue:1 | Enhancing Antimicrobial Peptide Potency through Multivalent Presentation on Coiled-Coil Nanofibrils. |
| AID726193 | Antibacterial activity against betalactamase positive Haemophilus influenzae by agar dilution method | 2013 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 23, Issue:5 | Synthesis and antibacterial activities of new piperidine substituted (5R)-[1,2,3]triazolylmethyl and (5R)-[(4-F-[1,2,3]triazolyl)methyl] oxazolidinones. |
| AID548527 | Antimicrobial activity against Oxacillin-susceptible coagulase-negative Staphylococcus by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Activities of dalbavancin against a worldwide collection of 81,673 gram-positive bacterial isolates. |
| AID558722 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus 547 measured on day 45 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID533964 | Bacteriostatic activity against Staphylococcus epidermidis infected in THP1 cells after 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Cellular pharmacodynamics of the novel biaryloxazolidinone radezolid: studies with infected phagocytic and nonphagocytic cells, using Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Legionella pneumophila. |
| AID283630 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus Ho 4280-0258 with heterozygous 23S rRNA G2576U mutation | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | In vitro activity of the oxazolidinone RWJ-416457 against linezolid-resistant and -susceptible staphylococci and enterococci. |
| AID531552 | Antibacterial activity against methicillin resistant Staphylococcus aureus obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID1862414 | Antibacterial activity against vancomycin-resistant Enterococcus faecium ATCC 700221 assessed as reduction in visible bacterial growth incubated for 18 to 20 hrs by CLSI based broth microdilution analysis | 2022 | European journal of medicinal chemistry, Oct-05, Volume: 240 | Membrane acting Povarov-Doebner derived compounds potently disperse preformed multidrug resistant Gram-positive bacterial biofilms. |
| AID444054 | Oral bioavailability in human | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3 | Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. |
| AID533421 | Antimicrobial activity against Anaerococcus prevotii by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activities of doripenem, a new broad-spectrum carbapenem, against recently collected clinical anaerobic isolates, with emphasis on the Bacteroides fragilis group. |
| AID561235 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus assessed as intermediate isolates by CLSI M100-S17 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | AFN-1252, a FabI inhibitor, demonstrates a Staphylococcus-specific spectrum of activity. |
| AID1174908 | Antibacterial activity against linezolid-resistant methicillin-resistant Staphylococcus epidermidis by broth microdilution method | 2014 | Bioorganic & medicinal chemistry, Dec-15, Volume: 22, Issue:24 | New potent antibacterials against Gram-positive multiresistant pathogens: effects of side chain modification and chirality in linezolid-like 1,2,4-oxadiazoles. |
| AID285115 | Antimicrobial activity against viridans group Streptococcus oralis at 0.5 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID559560 | Antimicrobial activity against compound-intermediate susceptible Coxiella burnetii isolate CP7 obtained from patient with acute Q fever infected in african green monkey Vero cells after 24 hrs by shell vial assay | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Bacteriostatic and bactericidal activities of tigecycline against Coxiella burnetii and comparison with those of six other antibiotics. |
| AID541033 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 infected in Albino guiena pig assessed as decrease in planktonic bacterial counts in cage fluid at 50 mg/kg after measured on day 10 postinfection | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Linezolid alone or combined with rifampin against methicillin-resistant Staphylococcus aureus in experimental foreign-body infection. |
| AID1862424 | Antibacterial activity against methicillin-resistant Staphylococcus aureus USA 300 (ARLG 1561) assessed as reduction in visible bacterial growth incubated for 18 to 20 hrs by CLSI based broth microdilution analysis | 2022 | European journal of medicinal chemistry, Oct-05, Volume: 240 | Membrane acting Povarov-Doebner derived compounds potently disperse preformed multidrug resistant Gram-positive bacterial biofilms. |
| AID261064 | Antibacterial activity against Haemophilus influenzae HI3542 | 2006 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 16, Issue:5 | Conformational constraint in oxazolidinone antibacterials. Part 2: Synthesis and structure-activity studies of oxa-, aza-, and thiabicyclo[3.1.0]hexylphenyl oxazolidinones. |
| AID318361 | Antibacterial activity against efflux negative-tolC mutant containing Escherichia coli | 2007 | Proceedings of the National Academy of Sciences of the United States of America, May-01, Volume: 104, Issue:18 | Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties. |
| AID410205 | Antibacterial activity against Enterococcus faecalis by broth micro dilution method | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24 | A facile synthesis, antibacterial, and antitubercular studies of some piperidin-4-one and tetrahydropyridine derivatives. |
| AID1407930 | Antibacterial activity against Staphylococcus aureus ATCC 29213 after 24 hrs by broth microdilution method | 2018 | European journal of medicinal chemistry, Sep-05, Volume: 157 | Discovery of dual GyrB/ParE inhibitors active against Gram-negative bacteria. |
| AID373848 | Antimicrobial activity against vancomycin-resistant Staphylococcus aureus 510 Hershey after 14 passages with quinupristin-dalfopristin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID583199 | Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus after 24 hrs by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | In vitro activity of the new multivalent glycopeptide-cephalosporin antibiotic TD-1792 against vancomycin-nonsusceptible Staphylococcus isolates. |
| AID1760595 | Antibacterial activity against Methicillin resistant Staphylococcus aureus 43300 assessed as inhibition of bacterial growth measured after 24 hrs | 2021 | European journal of medicinal chemistry, Feb-05, Volume: 211 | Installation of an aryl boronic acid function into the external section of N-aryl-oxazolidinones: Synthesis and antimicrobial evaluation. |
| AID209767 | Minimum inhibitory concentration against Streptococcus pyogenes MTCC 442 | 2004 | Bioorganic & medicinal chemistry letters, Jun-21, Volume: 14, Issue:12 | Oxazolidinone: search for highly potent antibacterial. |
| AID1539450 | Antibacterial activity against vancomycin-resistant Staphylococcus aureus isolate 12 after 18 to 20 hrs in aerobic condition by CLSI-based broth microdilution assay | |||
| AID206236 | In vitro antibacterial activity against Staphylococcus aures strain ATCC 29213 | 1996 | Journal of medicinal chemistry, Feb-02, Volume: 39, Issue:3 | Synthesis and antibacterial activity of U-100592 and U-100766, two oxazolidinone antibacterial agents for the potential treatment of multidrug-resistant gram-positive bacterial infections. |
| AID67401 | In vitro antibacterial activity against vancomycin-resistant Enterococcus faecalis C6487 | 2003 | Bioorganic & medicinal chemistry letters, Jul-07, Volume: 13, Issue:13 | Synthesis and in vitro activity of new methylenepiperidinyl and methylenepyrrolidinyl oxazolidinone antibacterial agents. |
| AID1421234 | Inhibition of recombinant human MAOA expressed in baculovirus infected Sf9 insect cells at 30 uM using luciferin derived substrate pretreated for 15 mins followed by substrate addition and measured after 60 mins by luminescence assay relative to control | 2018 | European journal of medicinal chemistry, Oct-05, Volume: 158 | Synthesis and antibacterial activity evaluation of novel biaryloxazolidinone analogues containing a hydrazone moiety as promising antibacterial agents. |
| AID566575 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus 5 by conventional agar-dilution method | 2011 | European journal of medicinal chemistry, Jan, Volume: 46, Issue:1 | Discovery of a novel nitroimidazolyl-oxazolidinone hybrid with potent anti Gram-positive activity: Synthesis and antibacterial evaluation. |
| AID410209 | Antibacterial activity against vancomycin-resistant Enterococcus faecium by broth micro dilution method | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24 | A facile synthesis, antibacterial, and antitubercular studies of some piperidin-4-one and tetrahydropyridine derivatives. |
| AID474998 | Antibacterial activity against Staphylococcus epidermidis LCB0003 by two fold serial dilution method | 2010 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 20, Issue:7 | Synthesis, crystal and antibacterial studies of diversely functionalized tetrahydropyridin-4-ol. |
| AID1596568 | Bactericidal activity against vancomycin resistant Enterococcus faecalis ATCC 51299 assessed as reduction in bacterial cell growth incubated for 18 to 20 hrs followed by re-plating on tryptic soy agar plates at 37 degC for 18 hrs by broth microdilution as | 2019 | European journal of medicinal chemistry, Aug-01, Volume: 175 | Lipophilic efficient phenylthiazoles with potent undecaprenyl pyrophosphatase inhibitory activity. |
| AID323782 | Antimicrobial activity against bioluminescent methicillin-susceptible Staphylococcus aureus Xen29 | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Rapid bactericidal activity of daptomycin against methicillin-resistant and methicillin-susceptible Staphylococcus aureus peritonitis in mice as measured with bioluminescent bacteria. |
| AID524722 | Antibacterial activity against linezolid-resistant Enterococcus faecium 03B1073 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro antibacterial activity of CE-156811, a novel analog derived from hygromycin A. |
| AID541531 | Antimicrobial activity against Enterococcus faecalis clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID1519271 | Antibacterial activity agianst methicillin-resistant Staphylococcus aureus | 2019 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 29, Issue:23 | Synthesis and antibacterial evaluation of novel oxazolidinone derivatives containing a piperidinyl moiety. |
| AID1578432 | Antimicrobial activity against cephalosporin-resistant Streptococcus pneumoniae ATCC 51916 by broth liquid microdilution method | 2020 | European journal of medicinal chemistry, Jan-01, Volume: 185 | Modifying the lipophilic part of phenylthiazole antibiotics to control their drug-likeness. |
| AID552833 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae | 2011 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1 | The discovery and structure-activity relationships leading to CE-156811, a difluorophenyl cyclopropyl fluoroether: a novel potent antibacterial analog derived from hygromycin A. |
| AID383559 | Antibacterial activity against Enterococcus faecalis ATCC 35550 by broth microdilution technique | 2008 | European journal of medicinal chemistry, Apr, Volume: 43, Issue:4 | Synthesis and in vitro antibacterial activities of novel oxazolidinones. |
| AID498885 | Antimicrobial activity against Pseudomonas aeruginosa OC 4351 assessed as inhibition of growth by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vivo activity of ceftobiprole in murine skin infections due to Staphylococcus aureus and Pseudomonas aeruginosa. |
| AID1680071 | Antibacterial activity against Staphylococcus aureus ATCC 29213 assessed as reduction in bacterial growth incubated for 16 to 20 hrs by CLSI-based broth microdilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Synthesis and antibacterial bioactivities of cationic deacetyl linezolid amphiphiles. |
| AID444058 | Volume of distribution at steady state in human | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3 | Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. |
| AID519090 | Antimicrobial activity against Staphylococcus aureus RN4220 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Linezolid and tiamulin cross-resistance in Staphylococcus aureus mediated by point mutations in the peptidyl transferase center. |
| AID717874 | Antibacterial activity against methicillin-resistant Staphylococcus aureus OM481 by two-fold liquid microdilution method | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24 | Riccardin C derivatives as anti-MRSA agents: structure-activity relationship of a series of hydroxylated bis(bibenzyl)s. |
| AID1151743 | Antibacterial activity against Staphylococcus aureus measured after 5 serial passages | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID528711 | Antibacterial activity against methicillin resistant coagulase-negative Staphylococcus saprophyticus clinical isolate assessed as susceptibility level by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID555312 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus ATCC 29213 after 50 passages by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Antistaphylococcal activity of dihydrophthalazine antifolates, a family of novel antibacterial drugs. |
| AID577097 | T>MIC in Enterococcus faecalis ATCC 29212 in two-compartment pharmacokinetic/pharmacodynamic model at 600 mg, bid administered as 0.5 hr infusion for 2 days | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID565757 | Antimicrobial activity against oxacillin-susceptible Staphylococcus epidermidis clinical isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID1474196 | Antibacterial activity against vancomycin-resistant Enterococcus faecium ATCC 700221 after 18 to 22 hrs in absence of colistin by broth microdilution method | 2017 | Journal of medicinal chemistry, 03-23, Volume: 60, Issue:6 | Phenylthiazole Antibacterial Agents Targeting Cell Wall Synthesis Exhibit Potent Activity in Vitro and in Vivo against Vancomycin-Resistant Enterococci. |
| AID285000 | Antimicrobial activity against Enterococcus gallinarum at <= 0.06 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID284900 | Antimicrobial activity against glycopeptide-intermediate Staphylococcus aureus by broth microdilution technique after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Antimicrobial activities of ceragenins against clinical isolates of resistant Staphylococcus aureus. |
| AID1778666 | Ratio of MBC to MIC against penicillin-resistant Staphylococcus aureus | 2021 | European journal of medicinal chemistry, Oct-05, Volume: 221 | Design, synthesis and evaluation of novel 9-arylalkyl-10-methylacridinium derivatives as highly potent FtsZ-targeting antibacterial agents. |
| AID555297 | Antibacterial activity against methicillin-resistant coagulase-negative Staphylococcus aureus by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Antistaphylococcal activity of dihydrophthalazine antifolates, a family of novel antibacterial drugs. |
| AID1703718 | Antibacterial activity against vancomycin-resistant Staphylococcus aureus 10 assessed as inhibition of bacterial growth measured after 18 to 20 hrs by CLSI protocol based broth microdilution method | 2020 | European journal of medicinal chemistry, Sep-15, Volume: 202 | Evaluation of N-phenyl-2-aminothiazoles for treatment of multi-drug resistant and intracellular Staphylococcus aureus infections. |
| AID308917 | Antibacterial activity against Staphylococcus aureus ATCC 29213 by broth microdilution method | 2007 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 17, Issue:18 | Synthesis and in vitro antibacterial activity of novel methylamino piperidinyl oxazolidinones. |
| AID1271227 | Antibacterial activity against clinical isolate Neisseria meningitidis E-63 by microbroth dilution method | 2015 | ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11 | Design, Synthesis, and Identification of Silicon Incorporated Oxazolidinone Antibiotics with Improved Brain Exposure. |
| AID369440 | Antimicrobial activity against vancomycin-resistant Enterococcus faecalis after 20 to 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vitro activity of telavancin against gram-positive clinical isolates recently obtained in Europe. |
| AID572009 | Antibacterial activity against Fusobacterium mortiferum by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID1421238 | Stability in human liver microsomes assessed as parent compound remaining at 1.5 uM pretreated for 5 mins followed by NADPH addition measured after 45 mins by LC-MS analysis | 2018 | European journal of medicinal chemistry, Oct-05, Volume: 158 | Synthesis and antibacterial activity evaluation of novel biaryloxazolidinone analogues containing a hydrazone moiety as promising antibacterial agents. |
| AID285095 | Antimicrobial activity against viridans group Streptococcus intermedius at 0.12 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID524972 | Antibacterial activity against Streptococcus pyogenes clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Comparative surveillance study of telavancin activity against recently collected gram-positive clinical isolates from across the United States. |
| AID283610 | Antimicrobial activity against Enterococcus faecalis 1 L2 with heterozygous 23S rRNA G2576U mutation | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | In vitro activity of the oxazolidinone RWJ-416457 against linezolid-resistant and -susceptible staphylococci and enterococci. |
| AID583404 | Antimicrobial activity against vancomycin-resistant Staphylococcus aureus isolate MI assessed as bacterial count at 8 times MIC after 24 hrs by colony counting method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | In vitro activity of the new multivalent glycopeptide-cephalosporin antibiotic TD-1792 against vancomycin-nonsusceptible Staphylococcus isolates. |
| AID566577 | Antimicrobial activity against Pseudomonas aeruginosa ATCC 9027 by conventional agar-dilution method | 2011 | European journal of medicinal chemistry, Jan, Volume: 46, Issue:1 | Discovery of a novel nitroimidazolyl-oxazolidinone hybrid with potent anti Gram-positive activity: Synthesis and antibacterial evaluation. |
| AID1243927 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus USA200 assessed as reduction in bacterial growth incubated for 18 to 20 hrs at 37 degC by broth microdilution method | 2015 | European journal of medicinal chemistry, Aug-28, Volume: 101 | Discovery and characterization of aryl isonitriles as a new class of compounds versus methicillin- and vancomycin-resistant Staphylococcus aureus. |
| AID352921 | Antibacterial activity against Staphylococcus aureus C463 after 18 to 20 hrs by agar dilution method | 2009 | Bioorganic & medicinal chemistry letters, May-01, Volume: 19, Issue:9 | Synthesis and antibacterial activities of novel oxazolidinones having spiro[2,4]heptane moieties. |
| AID522897 | Antibacterial activity against vancomycin-intermediate Staphylococcus aureus isolate 1014 after 24 hrs by modified broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Antistaphylococcal activity of ACHN-490 tested alone and in combination with other agents by time-kill assay. |
| AID522905 | Antibacterial activity against vancomycin-intermediate Staphylococcus aureus isolate 1006 after 24 hrs by modified broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Antistaphylococcal activity of ACHN-490 tested alone and in combination with other agents by time-kill assay. |
| AID1271206 | Solubility of compound at pH 7.4 by HPLC analysis | 2015 | ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11 | Design, Synthesis, and Identification of Silicon Incorporated Oxazolidinone Antibiotics with Improved Brain Exposure. |
| AID1474263 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis ATCC 51299 after 14 serial passages measured after 18 hrs by broth microdillution method | 2017 | Journal of medicinal chemistry, 03-23, Volume: 60, Issue:6 | Phenylthiazole Antibacterial Agents Targeting Cell Wall Synthesis Exhibit Potent Activity in Vitro and in Vivo against Vancomycin-Resistant Enterococci. |
| AID548739 | Antimicrobial activity against Oxacillin-susceptible coagulase-negative Staphylococcus assessed as percent susceptible isolate by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Activities of dalbavancin against a worldwide collection of 81,673 gram-positive bacterial isolates. |
| AID558512 | Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus 1287 measured on day 25 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID1167735 | Antimicrobial activity against Haemophilus influenzae by broth microdilution method | 2014 | Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21 | Novel DNA gyrase inhibiting spiropyrimidinetriones with a benzisoxazole scaffold: SAR and in vivo characterization. |
| AID1435927 | Antibacterial activity against vancomycin-resistant Staphylococcus aureus VRSA10 clinical isolate after 18 to 20 hrs by broth microdilution method | 2017 | European journal of medicinal chemistry, Jan-27, Volume: 126 | Phenylthiazole antibiotics: A metabolism-guided approach to overcome short duration of action. |
| AID1519051 | Stability in human liver microsomes assessed as intrinsic clearance at 1.5 uM preincubated for 5 mins with NADPH and measured after 45 mins by LC/MS analysis | 2020 | European journal of medicinal chemistry, Jan-01, Volume: 185 | Optimization of biaryloxazolidinone as promising antibacterial agents against antibiotic-susceptible and antibiotic-resistant gram-positive bacteria. |
| AID528731 | Antibacterial activity against penicillin intermediate Streptococcus pneumoniae clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID581025 | Inhibition of RNA synthesis in Staphylococcus epidermidis ATCC 23760 assessed as incorporation of [3H]uridine at 2 ug/ml by liquid scintillation counter | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Mode of action of Ranbezolid against staphylococci and structural modeling studies of its interaction with ribosomes. |
| AID67565 | In vitro minimum inhibitory concentration against Enterococcus faecalis | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | New classes of antibacterial oxazolidinones with C-5, methylene O-linked heterocyclic side chains. |
| AID1703707 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus ATCC 6538 assessed as inhibition of bacterial growth measured after 18 to 20 hrs by CLSI broth microdilution method | 2020 | European journal of medicinal chemistry, Sep-15, Volume: 202 | Evaluation of N-phenyl-2-aminothiazoles for treatment of multi-drug resistant and intracellular Staphylococcus aureus infections. |
| AID410111 | Antimicrobial activity against vanA+ expressing Enterococcus faecalis A6349 by NCCLS method | 2008 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 18, Issue:23 | Design at the atomic level: design of biaryloxazolidinones as potent orally active antibiotics. |
| AID519999 | Antimicrobial activity against Streptococcus pyogenes harboring mef(A) gene | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID262233 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 700699 | 2006 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 16, Issue:6 | Novel 4-N-substituted aryl pent-2-ene-1,4-dione derivatives of piperazinyloxazolidinones as antibacterials. |
| AID1547717 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis 99 clinical isolate by broth microdilution method | 2020 | ACS medicinal chemistry letters, Mar-12, Volume: 11, Issue:3 | Structure-Activity Relationship for the Oxadiazole Class of Antibacterials. |
| AID571801 | Antibacterial activity against Clostridium celerecrescens by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID208313 | Minimum inhibitory concentration measured against Streptococcus pneumoniae | 2002 | Bioorganic & medicinal chemistry letters, Aug-19, Volume: 12, Issue:16 | The synthesis and biological evaluation of a novel series of antimicrobials of the oxazolidinone class. |
| AID565015 | Bactericidal activity against methicillin-susceptible coagulase-negative Staphylococcus simulans after 24 hrs by plate counting method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID571824 | Antibacterial activity against Colinsella aerofaciens by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID1764092 | Antibacterial activity against methicillin-resistant Staphylococcus aureus USA300 assessed as bacterial growth inhibition measured by two-fold serial microdilution method | 2021 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 47 | Synthesis, optimization, in vitro and in vivo study of bicyclic substituted amine as MenA inhibitor. |
| AID353058 | Antibacterial activity against vancomycin-resistant Enterococcus 1 after 18 to 20 hrs by agar dilution method | 2009 | Bioorganic & medicinal chemistry letters, May-01, Volume: 19, Issue:9 | Synthesis and antibacterial activities of novel oxazolidinones having spiro[2,4]heptane moieties. |
| AID283172 | Effect on biofilm formation of Staphylococcus lugdunensis assessed as percent non-biofilm forming isolates | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | In vitro effects of antimicrobial agents on planktonic and biofilm forms of Staphylococcus lugdunensis clinical isolates. |
| AID571815 | Antibacterial activity against Actinomyces naeslundii by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID442574 | Antibacterial activity against methicillin and vancomycin-resistant Staphylococcus aureus ATCC 29213 after 24 hrs by spectrophotometry | 2010 | European journal of medicinal chemistry, Feb, Volume: 45, Issue:2 | Synthesis of nitroimidazole derived oxazolidinones as antibacterial agents. |
| AID429066 | Antiplasmodial activity after 120 hrs against Plasmodium falciparum 3D7 as Malstat LDH activity | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Telithromycin and quinupristin-dalfopristin induce delayed death in Plasmodium falciparum. |
| AID577140 | Apparent volume of distribution in two-compartment pharmacokinetic/pharmacodynamic model at 400 mg, bid administered as 0.5 hr infusion over 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID1680059 | Antibacterial activity against NDM1 producing carbapenem-resistant Enterobacteriaceae clinical isolate 9 assessed as reduction in bacterial growth incubated for 16 to 20 hrs by CLSI-based broth microdilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Synthesis and antibacterial bioactivities of cationic deacetyl linezolid amphiphiles. |
| AID285133 | Antimicrobial activity against viridans group Streptococcus sanguinis at 0.5 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID1649287 | Antibacterial activity against Enterococcus faecium SR16972 assessed as inhibition of bacterial growth incubated for 20 hrs by microdilution broth method | |||
| AID374008 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus 543 after 14 passages with CG400549 measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID575271 | Antimicrobial activity against penicillin-susceptible Streptococcus pneumoniae by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Comparative in vitro activity profiles of novel bis-indole antibacterials against gram-positive and gram-negative clinical isolates. |
| AID1879689 | Antimycobacterial activity against drug susceptible Mycobacterium tuberculosis H37Rv assessed as inhibition of bacterial growth measured after 2 weeks by microbroth dilution method | 2022 | European journal of medicinal chemistry, Mar-15, Volume: 232 | Synthesis and biological evaluation of orally active prodrugs and analogs of para-aminosalicylic acid (PAS). |
| AID1520487 | Antibacterial activity against methicillin-resistant Staphylococcus aureus infected in Kunming mouse dosed subcutaneously at 0.5 and 4.0 hrs postinfection and measured at 7 to 14 days post treatment by Bliss method | |||
| AID210054 | Compound was evaluated for minimum inhibitory concentration against Streptococcus pneumoniae 9753 strain | 2002 | Bioorganic & medicinal chemistry letters, Mar-25, Volume: 12, Issue:6 | Synthesis and antibacterial activity of linezolid analogues. |
| AID563320 | Antibacterial activity against vancomycin-susceptible Enterococcus faecalis EF 12704 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | In vivo activity of a novel anti-methicillin-resistant Staphylococcus aureus cephalosporin, ceftaroline, against vancomycin-susceptible and -resistant Enterococcus faecalis strains in a rabbit endocarditis model: a comparative study with linezolid and van |
| AID71095 | In vitro antibacterial activity against Escherichia coli strain ATCC 25922 | 1996 | Journal of medicinal chemistry, Feb-02, Volume: 39, Issue:3 | Synthesis and antibacterial activity of U-100592 and U-100766, two oxazolidinone antibacterial agents for the potential treatment of multidrug-resistant gram-positive bacterial infections. |
| AID1250833 | Antibacterial activity against methicillin-resistant Staphylococcus aureus incubated for 18 hrs by agar dilution method | 2015 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 25, Issue:20 | Discovery of a potent enoyl-acyl carrier protein reductase (FabI) inhibitor suitable for antistaphylococcal agent. |
| AID499165 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus OC 8525 infected in SKH1 mouse assessed as log change in bacterial colony forming unit per gram of skin tissue at 1.6 mg/kg/day, po (Rvb = 0.8 deltalog CFU) | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vivo activity of ceftobiprole in murine skin infections due to Staphylococcus aureus and Pseudomonas aeruginosa. |
| AID1591546 | Ratio of MBC for Staphylococcus aureus ATCC 25923 to MIC for Staphylococcus aureus ATCC 25923 | 2019 | Bioorganic & medicinal chemistry, 07-15, Volume: 27, Issue:14 | Discovery of 1,3,4-oxadiazol-2-one-containing benzamide derivatives targeting FtsZ as highly potent agents of killing a variety of MDR bacteria strains. |
| AID1269333 | Apparent permeability from apical to basolateral side in human Caco2 cells | 2016 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 26, Issue:2 | Synthesis and evaluation of pretomanid (PA-824) oxazolidinone hybrids. |
| AID1493807 | Antibacterial activity against Staphylococcus aureus VRS12 clinical isolate after 20 hrs by broth microdilution method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Biphenylthiazole antibiotics with an oxadiazole linker: An approach to improve physicochemical properties and oral bioavailability. |
| AID1853456 | Antibacterial activity against Listeria monocytogenes ATCC 19115 assessed as bacterial growth inhibition incubated for 18 to 20 hrs by CLSI based broth microdilution assay | 2021 | RSC medicinal chemistry, Nov-17, Volume: 12, Issue:11 | SF |
| AID1862430 | Antibacterial activity against methicillin-resistant Staphylococcus aureus USA 300 (ARLG 1649) assessed as reduction in visible bacterial growth incubated for 18 to 20 hrs by CLSI based broth microdilution analysis | 2022 | European journal of medicinal chemistry, Oct-05, Volume: 240 | Membrane acting Povarov-Doebner derived compounds potently disperse preformed multidrug resistant Gram-positive bacterial biofilms. |
| AID1778648 | Antibacterial activity against vancomycin-susceptible Enterococcus faecalis ATCC19434 assessed as bacterial growth inhibition incubated for 24 hrs by CLSI protocol based broth microdilution method | 2021 | European journal of medicinal chemistry, Oct-05, Volume: 221 | Design, synthesis and evaluation of novel 9-arylalkyl-10-methylacridinium derivatives as highly potent FtsZ-targeting antibacterial agents. |
| AID260739 | Antibacterial activity against Staphylococcus aureus smith | 2006 | Journal of medicinal chemistry, Feb-23, Volume: 49, Issue:4 | Hybrid antibacterials. DNA polymerase-topoisomerase inhibitors. |
| AID520773 | Toxicity in methicillin-resistant Staphylococcus aureus-infected New Zealand rabbit osteomyelitis model assessed as body weight at 60 mg/kg, po administered every 8 hrs for 4 days measured on week 6 postinfection (Rvb = 2.43 +/- 0.15 kg) | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Efficacies of ceftobiprole medocaril and comparators in a rabbit model of osteomyelitis due to methicillin-resistant Staphylococcus aureus. |
| AID561513 | Antibacterial activity against Beta-hemolytic Streptococcus group B by CLSI broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Potency and bactericidal activity of iclaprim against recent clinical gram-positive isolates. |
| AID373654 | Antimicrobial activity against vancomycin-resistant Staphylococcus aureus 509 Michigan by agar dilution CLSI method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID1271214 | Cmax in BALB/c mouse brain at 10 mg/kg, po by LC-MS/MS analysis | 2015 | ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11 | Design, Synthesis, and Identification of Silicon Incorporated Oxazolidinone Antibiotics with Improved Brain Exposure. |
| AID1904083 | Antibacterial activity against Klebsiella pneumoniae BAA 2146 | 2022 | European journal of medicinal chemistry, Apr-05, Volume: 233 | Alternative approaches utilizing click chemistry to develop next-generation analogs of solithromycin. |
| AID662301 | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv grown in iron-deficient glycerol-alanine-salts media | 2012 | Bioorganic & medicinal chemistry, Jun-01, Volume: 20, Issue:11 | Syntheses and biological studies of novel spiropiperazinyl oxazolidinone antibacterial agents using a spirocyclic diene derived acylnitroso Diels-Alder reaction. |
| AID1873945 | Antibacterial activity against Staphylococcus aureus ATCC 29213 at pH 8.6 incubated for 16 to 20 hrs in presence of 5% foetal bovine serum by broth microdilution method | 2022 | European journal of medicinal chemistry, Aug-05, Volume: 238 | Design, synthesis and activity against drug-resistant bacteria evaluation of C-20, C-23 modified 5-O-mycaminosyltylonolide derivatives. |
| AID595022 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 | 2011 | Bioorganic & medicinal chemistry letters, May-15, Volume: 21, Issue:10 | Synthesis and in vitro activity of novel 1,2,4-triazolo[4,3-a]pyrimidine oxazolidinone antibacterial agents. |
| AID349308 | Antibacterial activity against methicillin-susceptible coagulase-negative Staphylococcus clinical isolate after 18 hrs by agar dilution method | 2008 | European journal of medicinal chemistry, May, Volume: 43, Issue:5 | Synthesis and structure-antibacterial activity of triazolyl oxazolidinones containing long chain acyl moiety. |
| AID561264 | Antibacterial activity against Enterococcus faecalis assessed as resistant isolates by CLSI M100-S17 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | AFN-1252, a FabI inhibitor, demonstrates a Staphylococcus-specific spectrum of activity. |
| AID625286 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatitis | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID560516 | Antimicrobial activity against SCCmec type III vancomycin-intermediate Staphylococcus aureus isolate 11b091 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID244872 | In vitro minimum inhibitory concentration against Enterococcus faecalis ATCC 29212 | 2005 | Bioorganic & medicinal chemistry letters, Jan-17, Volume: 15, Issue:2 | Effects of positional and geometrical isomerism on the biological activity of some novel oxazolidinones. |
| AID28199 | Plasma clearance in Male Sprague-Dawley Rat (25 mg/kg po); ND denotes not reported | 2003 | Journal of medicinal chemistry, Jan-16, Volume: 46, Issue:2 | Identification of phenylisoxazolines as novel and viable antibacterial agents active against Gram-positive pathogens. |
| AID303961 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis MGH2 EF1 by microbroth technology | 2007 | Journal of medicinal chemistry, Nov-29, Volume: 50, Issue:24 | Antibacterial oxazolidinones possessing a novel C-5 side chain. (5R)-trans-3-[3-Fluoro-4- (1-oxotetrahydrothiopyran-4-yl)phenyl]-2- oxooxazolidine-5-carboxylic acid amide (PF-00422602), a new lead compound. |
| AID564822 | Bactericidal activity against methicillin-resistant Staphylococcus aureus after 24 hrs by plate counting method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID1887614 | Synergistic antibacterial activity against Staphylococcus aureus ATCC 29213 assessed as fractional inhibitory concentration incubated for 24 hrs in presence of artocarpin by checkerboard method | 2022 | Journal of natural products, 10-28, Volume: 85, Issue:10 | Developing the Natural Prenylflavone Artocarpin from |
| AID373653 | Antimicrobial activity against community-acquired vancomycin-intermediate Staphylococcus aureus 504 by agar dilution CLSI method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID1578415 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus NRS 385 by broth liquid microdilution method | 2020 | European journal of medicinal chemistry, Jan-01, Volume: 185 | Modifying the lipophilic part of phenylthiazole antibiotics to control their drug-likeness. |
| AID524726 | Antibacterial activity against linezolid-resistant Enterococcus faecium 03B1078 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro antibacterial activity of CE-156811, a novel analog derived from hygromycin A. |
| AID561081 | Antibacterial activity against vancomycin-susceptible Enterococcus faecium by CLSI M7-A7 broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | In vitro activity of TR-700, the active ingredient of the antibacterial prodrug TR-701, a novel oxazolidinone antibacterial agent. |
| AID410107 | Antimicrobial activity against Haemophilus influenzae parent strain RD1 by NCCLS method | 2008 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 18, Issue:23 | Design at the atomic level: design of biaryloxazolidinones as potent orally active antibiotics. |
| AID1703710 | Antibacterial activity against methicillin-resistant Staphylococcus aureus NRS119 assessed as inhibition of bacterial growth measured after 18 to 20 hrs by CLSI protocol based broth microdilution method | 2020 | European journal of medicinal chemistry, Sep-15, Volume: 202 | Evaluation of N-phenyl-2-aminothiazoles for treatment of multi-drug resistant and intracellular Staphylococcus aureus infections. |
| AID255574 | In vitro minimum inhibitory concentration against Streptococcus pneumoniae ATCC 6303 after incubation in air at 35 degree C for 24 hr using agar dilution method | 2005 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 15, Issue:19 | Synthesis and SAR of novel oxazolidinones: discovery of ranbezolid. |
| AID571822 | Antibacterial activity against Bifidobacterium pseudolongum by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID1680037 | Antibacterial activity against NDM1 producing carbapenem-resistant Enterobacteriaceae clinical isolate 10 assessed as reduction in bacterial growth incubated for 16 to 20 hrs by CLSI-based broth microdilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Synthesis and antibacterial bioactivities of cationic deacetyl linezolid amphiphiles. |
| AID1873946 | Antibacterial activity against Staphylococcus aureus ATCC 29213 at pH 8.6 incubated for 16 to 20 hrs in presence of 10% foetal bovine serum by broth microdilution method | 2022 | European journal of medicinal chemistry, Aug-05, Volume: 238 | Design, synthesis and activity against drug-resistant bacteria evaluation of C-20, C-23 modified 5-O-mycaminosyltylonolide derivatives. |
| AID533975 | Antimicrobial activity against linezolid-susceptible Staphylococcus aureus ATCC 33591 infected in THP1 cells after 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Cellular pharmacodynamics of the novel biaryloxazolidinone radezolid: studies with infected phagocytic and nonphagocytic cells, using Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Legionella pneumophila. |
| AID1194832 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus incubated for 16 hrs by agar dilution method | 2015 | Bioorganic & medicinal chemistry letters, , Volume: 25, Issue:10 | Synthesis and structure-activity relationship studies of novel [6,6,5] tricyclic oxazolidinone derivatives as potential antibacterial agents. |
| AID511381 | Antibacterial activity against methicillin resistant coagulase negative Staphylococcus epidermidis by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Comparative in vitro activities of nemonoxacin (TG-873870), a novel nonfluorinated quinolone, and other quinolones against clinical isolates. |
| AID533416 | Antimicrobial activity against Peptoniphilus asaccharolyticus assessed as resistant isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activities of doripenem, a new broad-spectrum carbapenem, against recently collected clinical anaerobic isolates, with emphasis on the Bacteroides fragilis group. |
| AID559286 | Antimicrobial activity against recombination-deficient Enterococcus faecalis JH2-2 recA harboring nucleotides at position 2576 in rrlA 2576G, rrlB 2576G, rrlC 2576G/T and rrlD 2576T after 6 passages under Linezolid selective pressure by agar dilution meth | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Influence of recombination on development of mutational resistance to linezolid in Enterococcus faecalis JH2-2. |
| AID533947 | Antimicrobial activity against community acquired methicillin-resistant Staphylococcus aureus NRS384 after 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Cellular pharmacodynamics of the novel biaryloxazolidinone radezolid: studies with infected phagocytic and nonphagocytic cells, using Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Legionella pneumophila. |
| AID585160 | Antibacterial activity against Mycobacterium smegmatis harboring 23S rRNA C2499U mutant after 24 generation times | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Mutations in 23S rRNA at the peptidyl transferase center and their relationship to linezolid binding and cross-resistance. |
| AID245403 | In vitro minimum inhibitory concentration against methicillin-resistant Staphylococcus epidermidis (ATCC 23760) | 2005 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 15, Issue:12 | Synthesis and antibacterial activity of novel (un)substituted benzotriazolyl oxazolidinone derivatives. |
| AID308922 | Antibacterial activity against linezolid-resistant Staphylococcus aureus NRS 119 by broth microdilution method | 2007 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 17, Issue:18 | Synthesis and in vitro antibacterial activity of novel methylamino piperidinyl oxazolidinones. |
| AID245182 | Minimal inhibitory concentration against methicillin resistant Staphylococcus aureus ST450 | 2004 | Bioorganic & medicinal chemistry letters, Sep-20, Volume: 14, Issue:18 | Synthesis and antibacterial activity of some aryloxy/thioaryloxy oxazolidinone derivatives. |
| AID572011 | Antibacterial activity against Prevotella bivia by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID1519038 | Antibacterial activity against linezolid-resistant Enterococcus faecalis assessed as complete reduction in bacterial cell growth by CLSI protocol based broth liquid microdilution method | 2020 | European journal of medicinal chemistry, Jan-01, Volume: 185 | Optimization of biaryloxazolidinone as promising antibacterial agents against antibiotic-susceptible and antibiotic-resistant gram-positive bacteria. |
| AID524945 | Antibacterial activity against methicillin-susceptible coagulase-negative Staphylococcus cohnii clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Comparative surveillance study of telavancin activity against recently collected gram-positive clinical isolates from across the United States. |
| AID533941 | Antimicrobial activity against linezolid-resistant Enterococcus faecalis 412 harboring G2576U mutation in peptidyl transferase centre by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains. |
| AID520005 | Antimicrobial activity against Mycoplasma hominis isolated from human respiratory tract by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID311524 | Oral bioavailability in human | 2007 | Bioorganic & medicinal chemistry, Dec-15, Volume: 15, Issue:24 | Hologram QSAR model for the prediction of human oral bioavailability. |
| AID373650 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus by agar dilution CLSI method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID560213 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus in mouse systemic infection model | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | Molecular basis and phenotype of methicillin resistance in Staphylococcus aureus and insights into new beta-lactams that meet the challenge. |
| AID1308230 | Antibacterial activity against Staphylococcus haemolyticus ATCC 29970 incubated for 16 to 20 hrs by microdilution method | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10 | Structure-Activity Relationship for the 4(3H)-Quinazolinone Antibacterials. |
| AID542706 | fAUC (24 hrs) in Bacillus anthracis infected in vitro hollow fiber PK/PD model at simulated dose of 600 mg /day | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID1424067 | Antibiotic activity against methicillin-resistant Staphylococcus aureus isolate CAIRD142 by broth microdilution assay or Alamar blue dye based colorimetric assay | 2017 | Journal of natural products, 04-28, Volume: 80, Issue:4 | The Berkeleylactones, Antibiotic Macrolides from Fungal Coculture. |
| AID1898415 | Antibiofilm activity against methicillin-resistant vancomycin-resistant Enterococcus faecium ATCC 700221 biofilms assessed as biofilm eradication incubated for 24 hrs followed by incubation for 24 hrs in fresh medium by Calgary biofilm device assay | 2021 | Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11 | A Modular Synthetic Route Involving |
| AID368276 | Bactericidal activity against methicillin-resistant Staphylococcus aureus SA2 by microdilution technique | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vivo efficacy of ceftaroline (PPI-0903), a new broad-spectrum cephalosporin, compared with linezolid and vancomycin against methicillin-resistant and vancomycin-intermediate Staphylococcus aureus in a rabbit endocarditis model. |
| AID522903 | Antibacterial activity against vancomycin-intermediate Staphylococcus aureus isolate 1004 after 24 hrs by modified broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Antistaphylococcal activity of ACHN-490 tested alone and in combination with other agents by time-kill assay. |
| AID583197 | Antimicrobial activity against vancomycin-resistant Staphylococcus aureus isolate PA after 24 hrs by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | In vitro activity of the new multivalent glycopeptide-cephalosporin antibiotic TD-1792 against vancomycin-nonsusceptible Staphylococcus isolates. |
| AID1393960 | Antibacterial activity against methicillin resistant Staphylococcus aureus BAA-1685 after 16 to 20 hrs by CLSI method | 2018 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 28, Issue:16 | 3-Hydroxy-1,5-dihydro-2H-pyrrol-2-ones as novel antibacterial scaffolds against methicillin-resistant Staphylococcus aureus. |
| AID523027 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative in vitro antimicrobial activities of torezolid (TR-700), the active moiety of a new oxazolidinone, torezolid phosphate (TR-701), determination of tentative disk diffusion interpretive criteria, and quality control ranges. |
| AID196689 | tmax was evaluated in male Dawley rats at a dose of 25 mg/kg when taken perorally | 1998 | Journal of medicinal chemistry, Dec-17, Volume: 41, Issue:26 | Nitrogen-carbon-linked (azolylphenyl)oxazolidinones with potent antibacterial activity against the fastidious gram-negative organisms Haemophilus influenzae and Moraxella catarrhalis. |
| AID582987 | Antimicrobial activity against glycopeptide-resistant Enterococcus faecalis isolate HS0761 harboring MLST sequence type ST78 and pulsotype C expressing vanM gene cluster isolated from urine of patient by Etest | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | vanM, a new glycopeptide resistance gene cluster found in Enterococcus faecium. |
| AID1904921 | Antibacterial activity against Vancomycin-resistant Staphylococcus aureus 10 incubated for 18 to 20 hrs by broth microdilution method | 2022 | European journal of medicinal chemistry, Apr-15, Volume: 234 | Exploring the structure-activity relationships of diphenylurea as an antibacterial scaffold active against methicillin- and vancomycin-resistant Staphylococcus aureus. |
| AID1139107 | Antimicrobial activity against Staphylococcus aureus ATCC 29213 infected in Sprague-Dawley rat cyclophosphamide-induced neutropenic sepsis model assessed as host survival at 25 mg/kg, iv administered 1 hr before bacterial infection measured up to 120 hrs | 2014 | Bioorganic & medicinal chemistry letters, May-01, Volume: 24, Issue:9 | Successful application of serum shift prediction models to the design of dual targeting inhibitors of bacterial gyrase B and topoisomerase IV with improved in vivo efficacy. |
| AID561267 | Antibacterial activity against Enterococcus faecium assessed as intermediate isolates by CLSI M100-S17 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | AFN-1252, a FabI inhibitor, demonstrates a Staphylococcus-specific spectrum of activity. |
| AID565078 | Antibacterial activity against community-acquired methicillin-resistant Staphylococcus aureus 156 by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Pharmacodynamic profile of tigecycline against methicillin-resistant Staphylococcus aureus in an experimental pneumonia model. |
| AID474999 | Antibacterial activity against methicillin-resistant Staphylococcus epidermidis LCB0004 by two fold serial dilution method | 2010 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 20, Issue:7 | Synthesis, crystal and antibacterial studies of diversely functionalized tetrahydropyridin-4-ol. |
| AID285145 | Antimicrobial activity against viridans group Streptococcus bovis by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID134122 | Protective dose of subcutaneously administered compound against intraperitoneally-induced septicaemia model (Staphylococcus aureus HT-17) in murine | 2000 | Bioorganic & medicinal chemistry letters, Aug-07, Volume: 10, Issue:15 | Improved antibacterial activities of coumarin antibiotics bearing 5',5'-dialkylnoviose: biological activity of RU79115. |
| AID574955 | Antimicrobial activity against multiple drug resistant Streptococcus pneumoniae serotype 19F by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID1151703 | Antibacterial activity against Staphylococcus aureus by agar dilution method | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID1167995 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis clinical isolate 21/235 after overnight incubation by two-fold serial dilution method | 2014 | Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21 | Synthesis and biological evaluation of novel peptide BF2 as an antibacterial agent against clinical isolates of vancomycin-resistant enterococci. |
| AID687494 | Cmax in rat at 10 mg/kg, iv | 2012 | Bioorganic & medicinal chemistry, Oct-15, Volume: 20, Issue:20 | Antitubercular nitrofuran isoxazolines with improved pharmacokinetic properties. |
| AID285081 | Antimicrobial activity against viridans group Streptococcus bovis at 1 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID392201 | Antibacterial activity against Staphylococcus aureus UC-76 SA-1 by micro broth method | 2009 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 19, Issue:2 | Synthesis and structure-activity studies of novel homomorpholine oxazolidinone antibacterial agents. |
| AID531557 | Antibacterial activity against coagulase-negative Staphylococcus hominis obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID560574 | Bactericidal activity against vancomycin-susceptible Enterococcus faecalis ATCC 29212 assessed as change in bacterial count at 16 ug/ml by time-kill assay | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Impact of human serum albumin on oritavancin in vitro activity against enterococci. |
| AID575042 | Cmax in patient plasma at 600 mg, iv or 600 mg, po administered every 12 hrs by HPLC | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Therapeutic drug monitoring of linezolid: a retrospective monocentric analysis. |
| AID591665 | Antimicrobial activity against multidrug-resistant Moraxella catarrhalis after 18 hrs by agar dilution method | 2011 | Journal of medicinal chemistry, Apr-14, Volume: 54, Issue:7 | A new DNA gyrase inhibitor subclass of the cyclothialidine family based on a bicyclic dilactam-lactone scaffold. Synthesis and antibacterial properties. |
| AID637970 | Antibacterial activity against Haemophilus influenzae ATCC 31517 after overnight incubation by twofold broth dilution technique | 2012 | Bioorganic & medicinal chemistry, Jan-01, Volume: 20, Issue:1 | Efficient microwave-assisted synthesis, antibacterial activity and high fluorescence of 5 benzimidazolyl-2'-deoxyuridines. |
| AID268866 | Antibacterial activity against vancomycin-resistant Enterococcus faecium ATCC 12202 | 2006 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 16, Issue:16 | Synthesis of novel tricyclic oxazolidinones by a tandem SN2 and SNAr reaction: SAR studies on conformationally constrained analogues of Linezolid. |
| AID571792 | Antibacterial activity against Clostridium hathewayi by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID516161 | Antibacterial activity against methicillin-resistant Staphylococcus aureus clinical isolates assessed as resistant isolates by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | In vitro activity of telavancin against a contemporary worldwide collection of Staphylococcus aureus isolates. |
| AID1862432 | Antibacterial activity against methicillin-resistant Staphylococcus aureus USA 300 (ARLG 1665) assessed as reduction in visible bacterial growth incubated for 18 to 20 hrs by CLSI based broth microdilution analysis | 2022 | European journal of medicinal chemistry, Oct-05, Volume: 240 | Membrane acting Povarov-Doebner derived compounds potently disperse preformed multidrug resistant Gram-positive bacterial biofilms. |
| AID562387 | Antimicrobial activity against vancomycin-nonsusceptible Enterococcus faecalis clinical isolates assessed as percent susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID293551 | Antibacterial activity against Salmonella typhi MTCC 733 after 24 hrs by agar dilution assay | 2007 | European journal of medicinal chemistry, Jun, Volume: 42, Issue:6 | Organoiodine(III) mediated synthesis of 3,9-diaryl- and 3,9-difuryl-bis-1,2,4-triazolo[4,3-a][4,3-c]pyrimidines as antibacterial agents. |
| AID1151722 | Bacteriostatic activity against vancomycin-resistant Enterococcus faecium | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID405631 | Toxicity in rabbit liver mitochondria assessed as inhibition of mitochondrial protein synthesis | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Comparative study of the effects of pyridoxine, rifampin, and renal function on hematological adverse events induced by linezolid. |
| AID583410 | Antimicrobial activity against vancomycin-resistant Staphylococcus aureus isolate PA assessed as bacterial count at 32 times MIC after 24 hrs by colony counting method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | In vitro activity of the new multivalent glycopeptide-cephalosporin antibiotic TD-1792 against vancomycin-nonsusceptible Staphylococcus isolates. |
| AID318364 | Toxicity in human RBC assessed as drug level causing hemolysis | 2007 | Proceedings of the National Academy of Sciences of the United States of America, May-01, Volume: 104, Issue:18 | Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties. |
| AID533408 | Antimicrobial activity against Clostridium tertium assessed as resistant isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activities of doripenem, a new broad-spectrum carbapenem, against recently collected clinical anaerobic isolates, with emphasis on the Bacteroides fragilis group. |
| AID542923 | Antimicrobial activity against Bacillus anthracis infected in in vitro hollow fiber PK/PD model assessed as bacterial killing at 600 mg administered once every 24 hrs for 15 days | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID132092 | Tested for the dose to protect the mice from infection with Staphylococcus aureus OC 4172, by subcutaneous administration | 2004 | Bioorganic & medicinal chemistry letters, Jun-21, Volume: 14, Issue:12 | The synthesis and antimicrobial evaluation of a new series of isoxazolinyl oxazolidinones. |
| AID519086 | Antimicrobial activity against Escherichia coli KM87-88 harboring Arg141Ser mutation in rplC gene by agar dilution method in presence of 16 ug/ml polymyxin B nonapeptide | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Linezolid and tiamulin cross-resistance in Staphylococcus aureus mediated by point mutations in the peptidyl transferase center. |
| AID67386 | In vitro antibacterial activity against vancomycin-susceptible E. f. 034 (Enterococcus faecalis ATCC 29212) | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | Influence of ethylene-oxy spacer group on the activity of linezolid: synthesis of potent antibacterials possessing a thiocarbonyl group. |
| AID1151756 | Antibacterial activity against vancomycin-sensitive Enterococcus faecalis ATCC 29212 | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID308914 | Antibacterial activity against Enterococcus faecalis ATCC 29212 by broth microdilution method | 2007 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 17, Issue:18 | Synthesis and in vitro antibacterial activity of novel methylamino piperidinyl oxazolidinones. |
| AID562638 | Antimicrobial activity against Streptococcus mitis by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | In vitro activities of three new dihydrofolate reductase inhibitors against clinical isolates of gram-positive bacteria. |
| AID575047 | Cmin in human intensive care unit patient plasma at 600 mg, iv or 600 mg, po administered every 12 hrs by HPLC | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Therapeutic drug monitoring of linezolid: a retrospective monocentric analysis. |
| AID533970 | Antimicrobial activity against linezolid-susceptible Staphylococcus aureus NRS18 infected in THP1 cells assessed as log reduction in bacterial count after 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Cellular pharmacodynamics of the novel biaryloxazolidinone radezolid: studies with infected phagocytic and nonphagocytic cells, using Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Legionella pneumophila. |
| AID540211 | Fraction unbound in human after iv administration | 2008 | Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7 | Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. |
| AID562248 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus ATCC 29213 by CLSI broth microdilution assay | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Mutations in ribosomal protein L3 are associated with oxazolidinone resistance in staphylococci of clinical origin. |
| AID1574835 | Antibacterial activity against methicillin-resistant Staphylococcus aureus by broth liquid microdilution method | 2019 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 29, Issue:3 | Design and synthesis of biaryloxazolidinone derivatives containing a rhodanine or thiohydantoin moiety as novel antibacterial agents against Gram-positive bacteria. |
| AID1390469 | Antibacterial activity against linezolid-resistant Staphylococcus aureus O-128 | 2018 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 28, Issue:7 | Design, synthesis and biological evaluation of spiropyrimidinetriones oxazolidinone derivatives as antibacterial agents. |
| AID565482 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus by broth microdilution method in presence of 50% human plasma | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro bactericidal activity of iclaprim in human plasma. |
| AID285315 | Antimicrobial activity against Leuconostoc spp. by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Daptomycin susceptibility of unusual gram-positive bacteria: comparison of results obtained by the Etest and the broth microdilution method. |
| AID1168020 | Antibacterial activity against vancomycin-resistant Enterococcus faecium clinical isolate 30/48 after overnight incubation by two-fold serial dilution method | 2014 | Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21 | Synthesis and biological evaluation of novel peptide BF2 as an antibacterial agent against clinical isolates of vancomycin-resistant enterococci. |
| AID1594377 | Antibacterial activity against AcrAB-TolC deficient Escherichia coli JW25113 after 18 to 24 hrs in absence of colistin by broth microdilution method | 2019 | Bioorganic & medicinal chemistry, 05-01, Volume: 27, Issue:9 | Second-generation aryl isonitrile compounds targeting multidrug-resistant Staphylococcus aureus. |
| AID458450 | Antimicrobial activity against Bacillus subtilis ATCC 6633 at 2 mM after overnight incubation by agar diffusion method | 2010 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 20, Issue:3 | Syntheses and antibacterial activity studies of new oxazolidinones from nitroso Diels-Alder chemistry. |
| AID278908 | Antibacterial activity against methicillin-resistant Staphylococcus aureus | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | In vitro antibacterial activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. |
| AID577117 | ABBC (0 to 24 hrs) in Enterococcus faecalis Ef1497 MutM3 in two-compartment pharmacokinetic/pharmacodynamic model at 600 mg, bid administered as 0.5 hr infusion for 2 days | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID531572 | Antibacterial activity against Streptococcus mitis obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID562168 | Antimicrobial activity against vancomycin-resistant Staphylococcus aureus 509 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID405619 | Antibacterial activity against Enterococcus | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Comparative study of the effects of pyridoxine, rifampin, and renal function on hematological adverse events induced by linezolid. |
| AID1350035 | Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate 6 incubated overnight by agar dilution method | 2018 | Journal of natural products, 02-23, Volume: 81, Issue:2 | Biomimetic Stereoselective Sulfa-Michael Addition Leads to Platensimycin and Platencin Sulfur Analogues against Methicillin-Resistant Staphylococcus aureus. |
| AID533971 | Antimicrobial activity against linezolid-susceptible Staphylococcus aureus SA040 infected in THP1 cells assessed as log reduction in bacterial count after 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Cellular pharmacodynamics of the novel biaryloxazolidinone radezolid: studies with infected phagocytic and nonphagocytic cells, using Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Legionella pneumophila. |
| AID625284 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatic failure | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID278920 | Antibacterial activity against macrolide-resistant Streptococcus pyogenes | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | In vitro antibacterial activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. |
| AID534786 | Antimicrobial activity against community-acquired methicillin-resistant Staphylococcus aureus by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | In vitro activity of ceftaroline against community-associated methicillin-resistant, vancomycin-intermediate, vancomycin-resistant, and daptomycin-nonsusceptible Staphylococcus aureus isolates. |
| AID206449 | In vitro antibacterial activity against methicillin-resistant S. a. 019 (Staphylococcus aureus ATCC 33591 ) | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | Influence of ethylene-oxy spacer group on the activity of linezolid: synthesis of potent antibacterials possessing a thiocarbonyl group. |
| AID285048 | Antimicrobial activity against Enterococcus hirae by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID205584 | Compound was evaluated for minimum inhibitory concentration against Staphylococcus epidermidis 975 strain | 2002 | Bioorganic & medicinal chemistry letters, Mar-25, Volume: 12, Issue:6 | Synthesis and antibacterial activity of linezolid analogues. |
| AID511305 | Antibacterial activity against methicillin resistant coagulase negative Staphylococcus by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Comparative in vitro activities of nemonoxacin (TG-873870), a novel nonfluorinated quinolone, and other quinolones against clinical isolates. |
| AID1117387 | Antimicrobial activity against Pseudomonas aeruginosa K799/WT assessed as inhibition zone at 37 degC for 24 hrs by agar diffusion method | 2010 | MedChemComm, Aug-01, Volume: 1, Issue:2 | Syntheses and biological evaluation of new cephalosporin-oxazolidinone conjugates. |
| AID1269329 | Antimicrobial activity against Mycobacterium tuberculosis H37Rv assessed as growth inhibition after 7 days by microbroth dilution method | 2016 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 26, Issue:2 | Synthesis and evaluation of pretomanid (PA-824) oxazolidinone hybrids. |
| AID519083 | Antimicrobial activity against Escherichia coli KM74 harboring U2500A mutation in 23S rRNA by agar dilution method in presence of 16 ug/ml polymyxin B nonapeptide | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Linezolid and tiamulin cross-resistance in Staphylococcus aureus mediated by point mutations in the peptidyl transferase center. |
| AID1861530 | AUC in Beagle dog at 15 mg/kg, iv | 2022 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 71 | WCK 4034: A promising oxazolidinone for treating gram positive infections. |
| AID541090 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 during stationary growth phase by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Linezolid alone or combined with rifampin against methicillin-resistant Staphylococcus aureus in experimental foreign-body infection. |
| AID697274 | Antibacterial activity against linezolid-resistant Staphylococcus aureus ARC 3583 after 18 to 24 hrs by CLSI broth microdilution method | 2012 | Journal of medicinal chemistry, Aug-09, Volume: 55, Issue:15 | Novel N-linked aminopiperidine inhibitors of bacterial topoisomerase type II with reduced pK(a): antibacterial agents with an improved safety profile. |
| AID1117394 | Antimicrobial activity against Escherichia coli SG458 assessed as partially clear inhibition zone at 37 degC for 24 hrs by agar diffusion method | 2010 | MedChemComm, Aug-01, Volume: 1, Issue:2 | Syntheses and biological evaluation of new cephalosporin-oxazolidinone conjugates. |
| AID567489 | Antimicrobial activity against linezolid pretreated vancomycin-intermediate Staphylococcus aureus isolate 4 obtained from wound of patient by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Clinical outcomes by methicillin-resistant Staphylococcus aureus staphylococcal cassette chromosome mec type: isolates recovered from a phase IV clinical trial of linezolid and vancomycin for complicated skin and skin structure infections. |
| AID583195 | Antimicrobial activity against vancomycin-resistant Staphylococcus aureus isolate NY after 24 hrs by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | In vitro activity of the new multivalent glycopeptide-cephalosporin antibiotic TD-1792 against vancomycin-nonsusceptible Staphylococcus isolates. |
| AID263963 | Antibacterial activity against vancomycin-susceptible Enterococcus faecalis DRCC 034 | 2006 | Bioorganic & medicinal chemistry letters, May-01, Volume: 16, Issue:9 | Synthesis and antibacterial activity of novel oxazolidinones bearing N-hydroxyacetamidine substituent. |
| AID206281 | In vitro antibacterial activity against Staphylococcus aureus (S. a.) ATCC 29213. | 1999 | Bioorganic & medicinal chemistry letters, Sep-20, Volume: 9, Issue:18 | Synthesis and in vitro activity of new oxazolidinone antibacterial agents having substituted isoxazoles. |
| AID1578414 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus NRS384 by broth liquid microdilution method | 2020 | European journal of medicinal chemistry, Jan-01, Volume: 185 | Modifying the lipophilic part of phenylthiazole antibiotics to control their drug-likeness. |
| AID285154 | Antimicrobial activity against viridans group Streptococcus vestibularis by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID572555 | Antibacterial activity against multidrug-resistant Mycobacterium tuberculosis harboring gyrA D94A mutation by agar proportion method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | In vitro activities of linezolid against clinical isolates of Mycobacterium tuberculosis complex isolated in Taiwan over 10 years. |
| AID1350030 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus isolate 1 incubated overnight by agar dilution method | 2018 | Journal of natural products, 02-23, Volume: 81, Issue:2 | Biomimetic Stereoselective Sulfa-Michael Addition Leads to Platensimycin and Platencin Sulfur Analogues against Methicillin-Resistant Staphylococcus aureus. |
| AID569340 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 by broth micro dilution technique | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 | Design, synthesis and antibacterial activity of 3-methylenepyrrolidine formyl hydroxyamino derivatives as novel peptide deformylase inhibitors. |
| AID524982 | Antibacterial activity against Streptococcus sanguinis clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Comparative surveillance study of telavancin activity against recently collected gram-positive clinical isolates from across the United States. |
| AID565007 | Bactericidal activity against methicillin-susceptible coagulase-negative Staphylococcus epidermidis after 24 hrs by plate counting method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID571809 | Antibacterial activity against Clostridium sordellii by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID260743 | Antibacterial activity against Vancomycin resistant Enterococcus faecium VRE 700802 | 2006 | Journal of medicinal chemistry, Feb-23, Volume: 49, Issue:4 | Hybrid antibacterials. DNA polymerase-topoisomerase inhibitors. |
| AID285162 | Antimicrobial activity against non replicating persistence Mycobacterium tuberculosis H37Rv in anaerobic condition assessed as bacterial density after 10 days | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Low-oxygen-recovery assay for high-throughput screening of compounds against nonreplicating Mycobacterium tuberculosis. |
| AID1400057 | Antibacterial activity against Escherichia coli ATCC 10798 incubated for 24 hrs under aerobic condition by MABA | 2018 | Bioorganic & medicinal chemistry, 09-15, Volume: 26, Issue:17 | An antimycobacterial pleuromutilin analogue effective against dormant bacilli. |
| AID303970 | Antibacterial activity against Streptococcus pyogenes C203 by micro-broth technology | 2007 | Journal of medicinal chemistry, Nov-29, Volume: 50, Issue:24 | Antibacterial oxazolidinones possessing a novel C-5 side chain. (5R)-trans-3-[3-Fluoro-4- (1-oxotetrahydrothiopyran-4-yl)phenyl]-2- oxooxazolidine-5-carboxylic acid amide (PF-00422602), a new lead compound. |
| AID565761 | Antimicrobial activity against Staphylococcus aureus clinical isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID1578418 | Antimicrobial activity against vancomycin-resistant Staphylococcus aureus 12 by broth liquid microdilution method | 2020 | European journal of medicinal chemistry, Jan-01, Volume: 185 | Modifying the lipophilic part of phenylthiazole antibiotics to control their drug-likeness. |
| AID558496 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus 543 measured on day 15 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID763953 | Antibacterial activity against Moraxella catarrhalis clinical isolate 112 after 18 hrs by NCCLS agar dilution method | 2013 | European journal of medicinal chemistry, Aug, Volume: 66 | Synthesis and antibacterial activities of N-substituted-glycinyl 1H-1,2,3-triazolyl oxazolidinones. |
| AID319153 | Toxicity in rat at 20 mg/kg for 30 days | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7 | Linezolid (ZYVOX), the first member of a completely new class of antibacterial agents for treatment of serious gram-positive infections. |
| AID430948 | Antibacterial activity against Staphylococcus aureus ATCC 29213 assessed as inhibition of protein synthesis at 8 times MIC treated 5 mins before [3H]leucine challenge measured after 30 mins by [3H]leucine incorporation assay | 2009 | Journal of medicinal chemistry, Aug-27, Volume: 52, Issue:16 | Design, synthesis, and structure-activity relationships of benzophenone-based tetraamides as novel antibacterial agents. |
| AID571818 | Antibacterial activity against Bifidobacterium breve by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID208732 | Compound was evaluated for minimum inhibitory concentration against Streptococcus A 29 strain | 2002 | Bioorganic & medicinal chemistry letters, Mar-25, Volume: 12, Issue:6 | Synthesis and antibacterial activity of linezolid analogues. |
| AID210361 | In vitro antibacterial activity against penicillin susceptible Streptococcus pneumoniae UC19912 (PSSP) | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | The effect of remote chirality on the antibacterial activity of indolinyl, tetrahydroquinolyl and dihydrobenzoxazinyl oxazolidinones. |
| AID523784 | Antimicrobial activity against linezolid-susceptible coagulase-negative Staphylococcus by CLSI method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative activities of TR-700 (torezolid) against staphylococcal blood isolates collected in Spain. |
| AID559558 | Antimicrobial activity against compound-susceptible Coxiella burnetii isolate CP6 obtained from patient with acute Q fever infected in african green monkey Vero cells after 24 hrs by shell vial assay | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Bacteriostatic and bactericidal activities of tigecycline against Coxiella burnetii and comparison with those of six other antibiotics. |
| AID562188 | Antimicrobial activity against vancomycin-resistant Staphylococcus aureus 509 after 28 passages by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID1180574 | Antimicrobial activity against 2 times drug resistance selected Staphylococcus aureus ARC1692-2F by broth microdilution/CLSI method | 2014 | Journal of medicinal chemistry, Jul-24, Volume: 57, Issue:14 | Optimization of pyrrolamide topoisomerase II inhibitors toward identification of an antibacterial clinical candidate (AZD5099). |
| AID428279 | Antituberculosis activity against linezolid-resistant Mycobacterium tuberculosis having mutation in 23S rRNA with identical G to T base pair exchange at position 2061 | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro-selected linezolid-resistant Mycobacterium tuberculosis mutants. |
| AID373839 | Antimicrobial activity against vancomycin-resistant Staphylococcus aureus 509 Michigan after 14 passages with CG400549 measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID575170 | Inhibition of acrAB AcrAB-TolC-mediated Nile Red efflux in Escherichia coli K-12 3-AG100 overexpressing acrAB AcrAB-TolC assessed as time needed for 50% efflux after energization with 50 mM glucose at 200 uM by spectrofluorometric assay | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Optimized Nile Red efflux assay of AcrAB-TolC multidrug efflux system shows competition between substrates. |
| AID1421224 | Antibacterial activity against vancomycin-resistant Enterococcus faecium by broth liquid microdilution method | 2018 | European journal of medicinal chemistry, Oct-05, Volume: 158 | Synthesis and antibacterial activity evaluation of novel biaryloxazolidinone analogues containing a hydrazone moiety as promising antibacterial agents. |
| AID558728 | Antimicrobial activity against heterogeneous vancomycin-intermediate Staphylococcus aureus 873 measured on day 50 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID284973 | Antimicrobial activity against Corynebacterium pseudodiphtheriticum at 0.25 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID1304850 | Ratio of MIC for methicillin-resistant Staphylococcus aureus clinical isolate 2 in absence and presence of tiron | 2016 | Journal of medicinal chemistry, 04-28, Volume: 59, Issue:8 | Structure-Activity Relationships of a Diverse Class of Halogenated Phenazines That Targets Persistent, Antibiotic-Tolerant Bacterial Biofilms and Mycobacterium tuberculosis. |
| AID571797 | Antibacterial activity against Clostridium bartlettii by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID519991 | Antimicrobial activity against vancomycin-resistant Enterococcus faecalis nosocomial isolate | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID1167992 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis clinical isolate 7077 after overnight incubation by two-fold serial dilution method | 2014 | Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21 | Synthesis and biological evaluation of novel peptide BF2 as an antibacterial agent against clinical isolates of vancomycin-resistant enterococci. |
| AID244887 | Minimal inhibitory concentration against Enterococcus faecium 6A-VRE | 2004 | Bioorganic & medicinal chemistry letters, Sep-20, Volume: 14, Issue:18 | Synthesis and antibacterial activity of some aryloxy/thioaryloxy oxazolidinone derivatives. |
| AID525131 | Antibacterial activity against Staphylococcus aureus KM183 after 18 to 24 hrs by broth microdilution method selected after 16 ug/ml drug exposure for 6 hrs by culture absorbance method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Delayed development of linezolid resistance in Staphylococcus aureus following exposure to low levels of antimicrobial agents. |
| AID560589 | Free fraction in healthy human male at 600 mg, po every 12 hrs by LC/MS/MS analysis | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Impact of human serum albumin on oritavancin in vitro activity against enterococci. |
| AID410115 | Antimicrobial activity against Haemophilus influenzae 1100 by NCCLS method | 2008 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 18, Issue:23 | Design at the atomic level: design of biaryloxazolidinones as potent orally active antibiotics. |
| AID1151712 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID698976 | Antimycobacterial activity against Mycobacterium tuberculosis | 2012 | European journal of medicinal chemistry, May, Volume: 51 | Tuberculosis: the drug development pipeline at a glance. |
| AID1180583 | Ratio of MIC for 2 times drug resistance selected Staphylococcus aureus ARC1692-1F to MIC for Staphylococcus aureus ARC1692 | 2014 | Journal of medicinal chemistry, Jul-24, Volume: 57, Issue:14 | Optimization of pyrrolamide topoisomerase II inhibitors toward identification of an antibacterial clinical candidate (AZD5099). |
| AID255748 | In vivo effective dose (on day 7-post-infection) against methicillin-resistant Staphylococcus aureus 562 infected mice upon peroral administration at 30 min and 4 hr post-infection | 2005 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 15, Issue:19 | Synthesis and SAR of novel oxazolidinones: discovery of ranbezolid. |
| AID558488 | Antimicrobial activity against vancomycin-resistant Staphylococcus aureus 509 measured on day 10 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID1161218 | Antimicrobial activity against Staphylococcus aureus ATCC 33591 in septicemia mouse model assessed as mortality of host at 5 mg/kg administered intragastrically measured after 14 days relative to control | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | Synthesis, antibacterial activity, and biological evaluation of formyl hydroxyamino derivatives as novel potent peptide deformylase inhibitors against drug-resistant bacteria. |
| AID209292 | Compound was evaluated for minimum inhibitory concentration against Streptococcus pyogenes 102 strain | 2002 | Bioorganic & medicinal chemistry letters, Mar-25, Volume: 12, Issue:6 | Synthesis and antibacterial activity of linezolid analogues. |
| AID1596553 | Antibacterial activity against vancomycin resistant Staphylococcus aureus VRS11a assessed as reduction in bacterial cell growth incubated for 18 to 20 hrs by broth microdilution method | 2019 | European journal of medicinal chemistry, Aug-01, Volume: 175 | Lipophilic efficient phenylthiazoles with potent undecaprenyl pyrophosphatase inhibitory activity. |
| AID1616124 | Antimicrobial activity against Staphylococcus aureus ATCC 29213 | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Recent advancements in mechanistic studies and structure activity relationship of F |
| AID260736 | Binding affinity to Bacillus subtilis DNA polymerase3C | 2006 | Journal of medicinal chemistry, Feb-23, Volume: 49, Issue:4 | Hybrid antibacterials. DNA polymerase-topoisomerase inhibitors. |
| AID244931 | Minimal inhibitory concentration against Enterococcus faecalis ATCC 29212 | 2004 | Bioorganic & medicinal chemistry letters, Sep-20, Volume: 14, Issue:18 | Synthesis and antibacterial activity of some aryloxy/thioaryloxy oxazolidinone derivatives. |
| AID541543 | Antimicrobial activity against Enterococcus avium clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID1596550 | Antibacterial activity against Staphylococcus aureus ATCC 6538 assessed as reduction in bacterial cell growth incubated for 18 to 20 hrs by broth microdilution method | 2019 | European journal of medicinal chemistry, Aug-01, Volume: 175 | Lipophilic efficient phenylthiazoles with potent undecaprenyl pyrophosphatase inhibitory activity. |
| AID285040 | Antimicrobial activity against Corynebacterium amycolatum by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID387448 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus DRCC 035 | 2008 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 18, Issue:18 | Novel and potent oxazolidinone antibacterials featuring 3-indolylglyoxamide substituents. |
| AID531563 | Antibacterial activity against methicillin-resistant, oxacillin-susceptible, coagulase-negative, mecA-positive Staphylococcus lugdunensis obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID262235 | Antibacterial activity against Enterococcus faecalis ATCC 14506 | 2006 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 16, Issue:6 | Novel 4-N-substituted aryl pent-2-ene-1,4-dione derivatives of piperazinyloxazolidinones as antibacterials. |
| AID560812 | Apparent oral clearance in human adults with pulmonary tuberculosis at 600 mg administered twice daily for 7 days | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Population pharmacokinetics of linezolid in adults with pulmonary tuberculosis. |
| AID572001 | Antibacterial activity against Parabacteroides distasonis by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID533014 | Antibacterial activity against vancomycin-intermediate Staphylococcus aureus BR5-1 phenotypic revertant after 24 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Improved antimicrobial activity of linezolid against vancomycin-intermediate Staphylococcus aureus. |
| AID1168019 | Antibacterial activity against vancomycin-resistant Enterococcus faecium clinical isolate 29/203 after overnight incubation by two-fold serial dilution method | 2014 | Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21 | Synthesis and biological evaluation of novel peptide BF2 as an antibacterial agent against clinical isolates of vancomycin-resistant enterococci. |
| AID391591 | Antibacterial activity against penicillin-susceptible Streptococcus pneumoniae IID553 by agar dilution method | 2008 | Journal of medicinal chemistry, Oct-23, Volume: 51, Issue:20 | Synthesis and structure-activity relationship studies of highly potent novel oxazolidinone antibacterials. |
| AID564825 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus assessed as susceptible isolates after 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID17942 | Absolute bioavailability was evaluated in male Dawley rats at a dose of 25 mg/kg when taken perorally | 1998 | Journal of medicinal chemistry, Dec-17, Volume: 41, Issue:26 | Nitrogen-carbon-linked (azolylphenyl)oxazolidinones with potent antibacterial activity against the fastidious gram-negative organisms Haemophilus influenzae and Moraxella catarrhalis. |
| AID1861528 | AUC in Wistar rat at 15 mg/kg, iv | 2022 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 71 | WCK 4034: A promising oxazolidinone for treating gram positive infections. |
| AID583408 | Antimicrobial activity against vancomycin-resistant Staphylococcus aureus isolate PA assessed as bacterial count at 8 times MIC after 24 hrs by colony counting method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | In vitro activity of the new multivalent glycopeptide-cephalosporin antibiotic TD-1792 against vancomycin-nonsusceptible Staphylococcus isolates. |
| AID559555 | Antimicrobial activity against compound-susceptible Coxiella burnetii isolate CP5 obtained from patient with acute Q fever infected in african green monkey Vero cells after 24 hrs by shell vial assay | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Bacteriostatic and bactericidal activities of tigecycline against Coxiella burnetii and comparison with those of six other antibiotics. |
| AID565746 | Antimicrobial activity against vancomycin-susceptible Enterococcus faecium clinical isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID278913 | Antibacterial activity against methicillin-susceptible coagulase-negative staphylococci | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | In vitro antibacterial activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. |
| AID205559 | Minimum inhibitory concentration against Staphylococcus aureus ATCC 14154 | 2004 | Bioorganic & medicinal chemistry letters, Jun-21, Volume: 14, Issue:12 | Oxazolidinone: search for highly potent antibacterial. |
| AID575103 | Antimicrobial activity against Streptococcus pneumoniae serotype 23A assessed as percent susceptible isolates by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID1553371 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus ATCC 8235-4 measured after 16 hrs by broth microdilution method | 2019 | Bioorganic & medicinal chemistry letters, 09-15, Volume: 29, Issue:18 | Incorporation of a chiral gem-disubstituted nitrogen heterocycle yields an oxazolidinone antibiotic with reduced mitochondrial toxicity. |
| AID444055 | Fraction absorbed in human | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3 | Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. |
| AID1243925 | Antimicrobial activity against methicillin-sensitive Staphylococcus aureus NRS72 assessed as reduction in bacterial growth incubated for 18 to 20 hrs at 37 degC by broth microdilution method | 2015 | European journal of medicinal chemistry, Aug-28, Volume: 101 | Discovery and characterization of aryl isonitriles as a new class of compounds versus methicillin- and vancomycin-resistant Staphylococcus aureus. |
| AID759681 | Cytotoxicity against human HaCaT cells assessed as cell death at 200 to 400 ug/ml by MTT assay relative to control | 2013 | European journal of medicinal chemistry, Jul, Volume: 65 | New linezolid-like 1,2,4-oxadiazoles active against Gram-positive multiresistant pathogens. |
| AID1390482 | Antibacterial activity against Enterococcus faecium ATCC 35667 | 2018 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 28, Issue:7 | Design, synthesis and biological evaluation of spiropyrimidinetriones oxazolidinone derivatives as antibacterial agents. |
| AID373313 | Antibacterial activity against vancomycin-resistant Enterococcus clinical isolate after 18 hrs by NCCLS M7-A4 method | 2009 | European journal of medicinal chemistry, Mar, Volume: 44, Issue:3 | Synthesis, antibacterial and anticonvulsant evaluations of some cyclic enaminones. |
| AID531566 | Antibacterial activity against Enterococcus faecium obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID561233 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus by CLSI M100-S17 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | AFN-1252, a FabI inhibitor, demonstrates a Staphylococcus-specific spectrum of activity. |
| AID645045 | Antibacterial activity against Escherichia coli ATCC 25922 after 16 to 20 hrs by microbroth dilution method | 2012 | European journal of medicinal chemistry, Apr, Volume: 50 | Synthesis and preliminary antibacterial evaluation of Linezolid-like 1,2,4-oxadiazole derivatives. |
| AID83641 | The compound was evaluated for its anti-bacterial activity against Haemophilus influenzae UC 30063 | 1998 | Journal of medicinal chemistry, Dec-17, Volume: 41, Issue:26 | Nitrogen-carbon-linked (azolylphenyl)oxazolidinones with potent antibacterial activity against the fastidious gram-negative organisms Haemophilus influenzae and Moraxella catarrhalis. |
| AID520023 | Antimicrobial activity against Enterococcus faecalis A6343 | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID564816 | Antimicrobial activity against methicillin-resistant coagulase-negative Staphylococcus epidermidis after 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID577138 | Total clearance in two-compartment pharmacokinetic/pharmacodynamic model at 800 mg, bid administered as 0.5 hr infusion over 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID565484 | Bactericidal activity against methicillin-resistant Staphylococcus aureus after 24 hrs by M26-A method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro bactericidal activity of iclaprim in human plasma. |
| AID1852689 | Antibacterial activity against efflux pump lacking/recombinant OM pore producing Escherichia coli incubated for 24 hrs by twofold serial dilution method | |||
| AID303959 | Antibacterial activity against levofloxacin-oxacillin-resistant Staphylococcus aureus UC76 SA1 by micro-broth technology | 2007 | Journal of medicinal chemistry, Nov-29, Volume: 50, Issue:24 | Antibacterial oxazolidinones possessing a novel C-5 side chain. (5R)-trans-3-[3-Fluoro-4- (1-oxotetrahydrothiopyran-4-yl)phenyl]-2- oxooxazolidine-5-carboxylic acid amide (PF-00422602), a new lead compound. |
| AID576325 | Antibacterial activity against 10'4 to 10'5 CFU methicillin-resistant Staphylococcus aureus after 18 hrs by CLSI 2-fold agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | In vitro and in vivo activities of LCB01-0371, a new oxazolidinone. |
| AID585169 | Antibacterial activity against Mycobacterium smegmatis harboring 23S rRNA G2032A, U2504G mutant after 24 generation times | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Mutations in 23S rRNA at the peptidyl transferase center and their relationship to linezolid binding and cross-resistance. |
| AID1609287 | Antibacterial activity against methicilline-resistant Staphylococcus aureus NRS-119 after 18 to 20 hrs by CLSI-based broth microdilution assay | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Phenylthiazoles with nitrogenous side chain: An approach to overcome molecular obesity. |
| AID573125 | Antibacterial activity against penicillin-susceptible Streptococcus pneumoniae by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID575266 | Antimicrobial activity against methicillin-resistant Staphylococcus epidermidis by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Comparative in vitro activity profiles of novel bis-indole antibacterials against gram-positive and gram-negative clinical isolates. |
| AID519997 | Antimicrobial activity against Streptococcus pneumoniae ribosomal mutant | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID285352 | Decrease in Panton-Valentine leukocidin level in Staphylococcus aureus LUG855 in CCY medium | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Effect of antibiotics on Staphylococcus aureus producing Panton-Valentine leukocidin. |
| AID571988 | Antibacterial activity against Ruminococcus lactaris by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID1677784 | In-vivo antibacterial activity against Staphylococcus aureus infected in KM mouse model assessed as reduction in bacterial load in blood at 10 mg/kg, iv administered thrice daily and measured after 48 hrs | 2020 | Bioorganic & medicinal chemistry, 11-01, Volume: 28, Issue:21 | Design, synthesis of novel 4,5-dihydroisoxazole-containing benzamide derivatives as highly potent FtsZ inhibitors capable of killing a variety of MDR Staphylococcus aureus. |
| AID374011 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus 543 after 18 passages with quinupristin-dalfopristin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID1327098 | Antibacterial activity against Staphylococcus aureus NCIM 2079 measured after 12 hrs by spectrophotometric method | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Design, synthesis and biological evaluation of novel azaspiro analogs of linezolid as antibacterial and antitubercular agents. |
| AID533943 | Antimicrobial activity against linezolid-resistant Enterococcus faecalis 414 harboring G2576U mutation in peptidyl transferase centre by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains. |
| AID206463 | In vitro antibacterial activity against Staphylococcus aureus | 2003 | Bioorganic & medicinal chemistry letters, Jul-21, Volume: 13, Issue:14 | Synthesis and antibacterial activity of oxazolidinone containing sulphonyl group. |
| AID571810 | Antibacterial activity against Clostridium spiroforme by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID1327104 | Antitubercular activity against dormant stage Mycobacterium bovis BCG ATCC 35734 measured after 12 days by nitrate reductase assay | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Design, synthesis and biological evaluation of novel azaspiro analogs of linezolid as antibacterial and antitubercular agents. |
| AID564812 | Antimicrobial activity against methicillin-resistant coagulase-negative Staphylococcus haemolyticus after 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID560820 | AUC (0 to 12 hrs) in human adults with pulmonary tuberculosis at 600 mg administered once daily for 5 days | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Population pharmacokinetics of linezolid in adults with pulmonary tuberculosis. |
| AID1547707 | Antibacterial activity against Staphylococcus aureus NRS119 by broth microdilution method | 2020 | ACS medicinal chemistry letters, Mar-12, Volume: 11, Issue:3 | Structure-Activity Relationship for the Oxadiazole Class of Antibacterials. |
| AID1161217 | Antimicrobial activity against Staphylococcus aureus ATCC 33591 in septicemia mouse model assessed as mortality of host at 10 mg/kg administered intragastrically measured after 14 days relative to control | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | Synthesis, antibacterial activity, and biological evaluation of formyl hydroxyamino derivatives as novel potent peptide deformylase inhibitors against drug-resistant bacteria. |
| AID1205591 | Equilibrium solubility of the compound in phosphate buffer by LC-MS analysis | 2015 | Journal of medicinal chemistry, Apr-09, Volume: 58, Issue:7 | X-ray crystal structures of Escherichia coli RNA polymerase with switch region binding inhibitors enable rational design of squaramides with an improved fraction unbound to human plasma protein. |
| AID572005 | Antibacterial activity against Bacteroides thetaiotaomicron by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID68067 | Antibacterial activity against ciprofloxacin resistant and linezolid-resistant Enterococcus faecium (EF4011 LinR;CipR) | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | Novel oxazolidinone-quinolone hybrid antimicrobials. |
| AID523828 | Antimicrobial activity against linezolid-resistant coagulase-negative Staphylococcus assessed as inhibition of microbial growth at 16 ug/ml by CLSI method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative activities of TR-700 (torezolid) against staphylococcal blood isolates collected in Spain. |
| AID529681 | Antimicrobial activity against community-acquired methicillin-resistant Staphylococcus aureus by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Activities of ceftobiprole, linezolid, vancomycin, and daptomycin against community-associated and hospital-associated methicillin-resistant Staphylococcus aureus. |
| AID1430401 | Antibacterial activity against Staphylococcus epidermidis 209E after 24 to 48 hrs by macro-broth dilution method | 2017 | Bioorganic & medicinal chemistry letters, 03-01, Volume: 27, Issue:5 | Methylsulfonyl benzothiazoles (MSBT) derivatives: Search for new potential antimicrobial and anticancer agents. |
| AID303960 | Antibacterial activity against levofloxacin-penicillin-resistant Streptococcus pneumoniae SV1 SP3 by microbroth technology | 2007 | Journal of medicinal chemistry, Nov-29, Volume: 50, Issue:24 | Antibacterial oxazolidinones possessing a novel C-5 side chain. (5R)-trans-3-[3-Fluoro-4- (1-oxotetrahydrothiopyran-4-yl)phenyl]-2- oxooxazolidine-5-carboxylic acid amide (PF-00422602), a new lead compound. |
| AID542886 | fT>MIC in Bacillus anthracis infected in vitro hollow fiber PK/PD model at simulated dose of 800 mg administered once every 24 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID1193399 | Inhibition of recombinant Bacillus anthracis PurE assessed as change in melting temperature at 100 uM after 10 to 30 mins by high-throughput thermal shift screening | 2015 | Bioorganic & medicinal chemistry, Apr-01, Volume: 23, Issue:7 | Identification of Bacillus anthracis PurE inhibitors with antimicrobial activity. |
| AID1883848 | Antibacterial activity against Mycobacterium tuberculosis Erdman in acute Mtb infection BALB/c mouse model assessed as reduction in log10 CFU in lungs at 100 mg/kg, po qd via gavage for 4 weeks | 2022 | Journal of medicinal chemistry, 06-09, Volume: 65, Issue:11 | Tuberculosis Drug Discovery: Challenges and New Horizons. |
| AID572021 | Antibacterial activity against Prevotella oralis by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID528715 | Antibacterial activity against methicillin resistant coagulase-negative Staphylococcus auricularis clinical isolate assessed as susceptibility level by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID208630 | Inhibitory activity against Streptococcus pneumoniae | 1996 | Journal of medicinal chemistry, Sep-27, Volume: 39, Issue:20 | New directions in antibacterial research. |
| AID1770349 | Antibacterial activity against penicillin-resistant Staphylococcus epidermidis assessed as inhibition of bacterial growth measured after 20 hrs by two-fold microdilution assay | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Modification of 5-methylphenanthridium from benzothiazoles to indoles as potent FtsZ inhibitors: Broadening the antibacterial spectrum toward vancomycin-resistant enterococci. |
| AID637967 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 after overnight incubation by twofold broth dilution technique | 2012 | Bioorganic & medicinal chemistry, Jan-01, Volume: 20, Issue:1 | Efficient microwave-assisted synthesis, antibacterial activity and high fluorescence of 5 benzimidazolyl-2'-deoxyuridines. |
| AID1584840 | Antibacterial activity against methicillin and vancomycin intermediate resistant Staphylococcus aureus MU50 after 18 to 24 hrs by microdilution assay | 2018 | European journal of medicinal chemistry, Nov-05, Volume: 159 | 1-(2-Hydroxybenzoyl)-thiosemicarbazides are promising antimicrobial agents targeting d-alanine-d-alanine ligase in bacterio. |
| AID429422 | Antibacterial activity against Streptococcus pneumoniae by agar dilution method | 2009 | European journal of medicinal chemistry, Aug, Volume: 44, Issue:8 | Synthesis and antibacterial activity of novel 5-(4-methyl-1H-1,2,3-triazole) methyl oxazolidinones. |
| AID68242 | In vitro antibacterial activity against Enterococcus faecium C6301 (E.f.2). | 1999 | Bioorganic & medicinal chemistry letters, Sep-20, Volume: 9, Issue:18 | Synthesis and in vitro activity of new oxazolidinone antibacterial agents having substituted isoxazoles. |
| AID1390459 | Antibacterial activity against vancomycin-resistant Enterococcus faecium R1 | 2018 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 28, Issue:7 | Design, synthesis and biological evaluation of spiropyrimidinetriones oxazolidinone derivatives as antibacterial agents. |
| AID289867 | Antibacterial activity against Enterococcus faecalis NCTC 12201 | 2007 | European journal of medicinal chemistry, Apr, Volume: 42, Issue:4 | Synthesis, SAR and antibacterial studies on novel chalcone oxazolidinone hybrids. |
| AID533397 | Antimicrobial activity against Clostridium paraputrificum by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activities of doripenem, a new broad-spectrum carbapenem, against recently collected clinical anaerobic isolates, with emphasis on the Bacteroides fragilis group. |
| AID573867 | Antibacterial activity against community-associated methicillin-resistant Staphylococcus aureus OC8525 infected in po dosed Swiss Webster mouse administered at 1 to 3 hrs post infection measured after 3 days | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | In vivo activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. |
| AID583198 | Antimicrobial activity against vancomycin-resistant Staphylococcus aureus isolate MI after 24 hrs by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | In vitro activity of the new multivalent glycopeptide-cephalosporin antibiotic TD-1792 against vancomycin-nonsusceptible Staphylococcus isolates. |
| AID531575 | Antibacterial activity against Bacillus spp. obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID1151720 | Bacteriostatic activity against vancomycin-sensitive Enterococcus faecium | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID1311364 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 29213 measured after 18 hrs by broth microdilution assay | 2016 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15 | An evolved oxazolidinone with selective potency against Mycobacterium tuberculosis and gram positive bacteria. |
| AID1907630 | Antibacterial activity against Escherichia coli incubated for 18 to 20 hrs by double dilution method | 2022 | European journal of medicinal chemistry, Jun-05, Volume: 236 | Novel benzothiazole‒urea hybrids: Design, synthesis and biological activity as potent anti-bacterial agents against MRSA. |
| AID1161138 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus after 24 hrs by broth microdilution method | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | Synthesis, antibacterial activity, and biological evaluation of formyl hydroxyamino derivatives as novel potent peptide deformylase inhibitors against drug-resistant bacteria. |
| AID519989 | Antimicrobial activity against coagulase-negative Staphylococcus nosocomial isolate | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID523806 | Antimicrobial activity against oxacillin-susceptible Staphylococcus aureus assessed as inhibition of microbial growth at 1 ug/ml by CLSI method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative activities of TR-700 (torezolid) against staphylococcal blood isolates collected in Spain. |
| AID284978 | Antimicrobial activity against Corynebacterium striatum at 0.25 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID285148 | Antimicrobial activity against viridans group Streptococcus intermedius by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID561237 | Antibacterial activity against methicillin-resistant Staphylococcus aureus by CLSI M100-S17 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | AFN-1252, a FabI inhibitor, demonstrates a Staphylococcus-specific spectrum of activity. |
| AID206305 | In vitro antibacterial activity against Staphylococcus aureus UC12673 (SA2) | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | The effect of remote chirality on the antibacterial activity of indolinyl, tetrahydroquinolyl and dihydrobenzoxazinyl oxazolidinones. |
| AID558711 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus 525 measured on day 40 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID1304849 | Antibacterial activity against methicillin-resistant Staphylococcus aureus clinical isolate 2 incubated for 16 hrs by broth microdilution method in presence of Fe2+ | 2016 | Journal of medicinal chemistry, 04-28, Volume: 59, Issue:8 | Structure-Activity Relationships of a Diverse Class of Halogenated Phenazines That Targets Persistent, Antibiotic-Tolerant Bacterial Biofilms and Mycobacterium tuberculosis. |
| AID1680006 | Induction of cytoplasmic membrane depolarization in Escherichia coli ATCC 25922 at 20 ug/ml measured for 12 mins by DiSC35 dye-based fluorescence assay | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Synthesis and antibacterial bioactivities of cationic deacetyl linezolid amphiphiles. |
| AID374590 | Antimicrobial activity against Bacillus pumilus MTCC 1456 after 24 hrs by agar dilution assay | 2009 | European journal of medicinal chemistry, Apr, Volume: 44, Issue:4 | Synthesis and antibacterial activity of some new 2,3-dimethoxy-3-hydroxy-2-(1-phenyl-3-aryl-4-pyrazolyl)chromanones. |
| AID1174907 | Antibacterial activity against linezolid-sensitive methicillin-resistant Staphylococcus aureus by broth microdilution method | 2014 | Bioorganic & medicinal chemistry, Dec-15, Volume: 22, Issue:24 | New potent antibacterials against Gram-positive multiresistant pathogens: effects of side chain modification and chirality in linezolid-like 1,2,4-oxadiazoles. |
| AID574078 | Ratio of fAUC (24 hrs) for Methicillin-susceptible Staphylococcus aureus ATCC 13709 infected po dosed mouse to MIC for Methicillin-susceptible Staphylococcus aureus ATCC 1370 | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | In vivo activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. |
| AID520003 | Antimicrobial activity against Legionella pneumophila isolated from human respiratory tract by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID429426 | Antibacterial activity against Haemophilus influenzae isolate 280 by agar dilution method | 2009 | European journal of medicinal chemistry, Aug, Volume: 44, Issue:8 | Synthesis and antibacterial activity of novel 5-(4-methyl-1H-1,2,3-triazole) methyl oxazolidinones. |
| AID529885 | Antibacterial activity against Staphylococcus aureus RN4220 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Discovery and characterization of QPT-1, the progenitor of a new class of bacterial topoisomerase inhibitors. |
| AID1151714 | Antibacterial activity against methicillin-sensitive Staphylococcus epidermidis | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID558087 | Antimicrobial activity against Ureaplasma parvum isolated from human by two fold serial dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Comparative in vitro susceptibilities of human mycoplasmas and ureaplasmas to a new investigational ketolide, CEM-101. |
| AID516165 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus clinical isolates by CLSi method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | In vitro activity of telavancin against a contemporary worldwide collection of Staphylococcus aureus isolates. |
| AID284986 | Antimicrobial activity against Enterococcus avium at 4 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID585171 | Antibacterial activity against Mycobacterium smegmatis harboring 23S rRNA C2055A, U2504G mutant after 24 generation times | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Mutations in 23S rRNA at the peptidyl transferase center and their relationship to linezolid binding and cross-resistance. |
| AID1852699 | Selectivity ratio of IC50 for efflux pump lacking Pseudomonas aeruginosa to IC50 for efflux pump lacking/OM pore producing Pseudomonas aeruginosa | |||
| AID370017 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus Smith infected in C3H mouse assessed as mortality at 6.25 mg/kg/day, iv administered within 15 mins of infection measured after 48 hrs by organ burden assay relative to control | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vivo efficacy of a novel oxazolidinone compound in two mouse models of infection. |
| AID566574 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus 3 by conventional agar-dilution method | 2011 | European journal of medicinal chemistry, Jan, Volume: 46, Issue:1 | Discovery of a novel nitroimidazolyl-oxazolidinone hybrid with potent anti Gram-positive activity: Synthesis and antibacterial evaluation. |
| AID405139 | Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate assessed as percent susceptible isolates by CLSI dilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro activities of CG400549, a novel FabI inhibitor, against recently isolated clinical staphylococcal strains in Korea. |
| AID533405 | Antimicrobial activity against Clostridium tertium by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activities of doripenem, a new broad-spectrum carbapenem, against recently collected clinical anaerobic isolates, with emphasis on the Bacteroides fragilis group. |
| AID562165 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus 540 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID368285 | AUC in rabbit plasma at 58 mg/kg after 12 hrs | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vivo efficacy of ceftaroline (PPI-0903), a new broad-spectrum cephalosporin, compared with linezolid and vancomycin against methicillin-resistant and vancomycin-intermediate Staphylococcus aureus in a rabbit endocarditis model. |
| AID524968 | Antibacterial activity against vancomycin-resistant and teichoplanin-susceptible Enterococcus faecalis clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Comparative surveillance study of telavancin activity against recently collected gram-positive clinical isolates from across the United States. |
| AID255573 | In vitro minimum inhibitory concentration against Streptococcus pyogenes ATCC 19615 after incubation in air at 35 degree C for 24 hr using agar dilution method | 2005 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 15, Issue:19 | Synthesis and SAR of novel oxazolidinones: discovery of ranbezolid. |
| AID542916 | Antimicrobial activity against Bacillus anthracis infected in in vitro hollow fiber PK/PD model assessed as bacterial killing at 800 mg administered once every 24 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID548740 | Antimicrobial activity against Oxacillin-resistant coagulase-negative Staphylococcus assessed as percent susceptible isolate by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Activities of dalbavancin against a worldwide collection of 81,673 gram-positive bacterial isolates. |
| AID13097 | Tmax of compound (25 mg/kg) after po administration was determined in Sprague-Dawley rat | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | The effect of remote chirality on the antibacterial activity of indolinyl, tetrahydroquinolyl and dihydrobenzoxazinyl oxazolidinones. |
| AID562623 | Antimicrobial activity against Coagulase-negative Staphylococcus assessed as susceptible isolates by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | In vitro activities of three new dihydrofolate reductase inhibitors against clinical isolates of gram-positive bacteria. |
| AID1327106 | Antibacterial activity against Escherichia coli NCIM 2688 at 10 ug/ml measured after 8 hrs by spectrophotometric method | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Design, synthesis and biological evaluation of novel azaspiro analogs of linezolid as antibacterial and antitubercular agents. |
| AID387459 | Tmax in Swiss albino mouse at 10 mg/kg, po | 2008 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 18, Issue:18 | Novel and potent oxazolidinone antibacterials featuring 3-indolylglyoxamide substituents. |
| AID522888 | Antibacterial activity against vancomycin-intermediate Staphylococcus aureus isolate 555 after 24 hrs by modified broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Antistaphylococcal activity of ACHN-490 tested alone and in combination with other agents by time-kill assay. |
| AID548743 | Antimicrobial activity against Vancomycin-susceptible Enterococcus faecium assessed as percent susceptible isolate by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Activities of dalbavancin against a worldwide collection of 81,673 gram-positive bacterial isolates. |
| AID583886 | Antibacterial activity against community-associated methicillin-resistant Staphylococcus aureus isolate 156 by broth microdilution assay | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Comparative efficacies of human simulated exposures of telavancin and vancomycin against methicillin-resistant Staphylococcus aureus with a range of vancomycin MICs in a murine pneumonia model. |
| AID1451769 | Antibacterial activity against Staphylococcus aureus Mu50 infected in BALB/c mouse assessed as reduction of bacterial burden in liver at 0.4 mg, ip bid for 4.5 days treated 24 hrs prior to bacterial infection measured 108 hrs post infection relative to co | 2017 | Journal of medicinal chemistry, 10-12, Volume: 60, Issue:19 | Novel Inhibitors of Staphyloxanthin Virulence Factor in Comparison with Linezolid and Vancomycin versus Methicillin-Resistant, Linezolid-Resistant, and Vancomycin-Intermediate Staphylococcus aureus Infections in Vivo. |
| AID561243 | Antibacterial activity against methicillin-susceptible Staphylococcus epidermidis assessed as intermediate isolates by CLSI M100-S17 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | AFN-1252, a FabI inhibitor, demonstrates a Staphylococcus-specific spectrum of activity. |
| AID284939 | Antimicrobial activity against Aerococcus spp. at <= 0.06 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID524984 | Antibacterial activity against penicillin susceptible Streptococcus pneumoniae clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Comparative surveillance study of telavancin activity against recently collected gram-positive clinical isolates from across the United States. |
| AID69612 | Antibacterial activity against Escherichia coli (OC 2530) (HS) | 2001 | Bioorganic & medicinal chemistry letters, Jul-23, Volume: 11, Issue:14 | Novel piperidinyloxy oxazolidinone antimicrobial agents. |
| AID1883681 | Antibacterial activity against Mycobacterium tuberculosis H37Rv assessed as inhibition of bacterial growth | 2022 | Journal of medicinal chemistry, 06-09, Volume: 65, Issue:11 | Tuberculosis Drug Discovery: Challenges and New Horizons. |
| AID1312937 | Antimicrobial activity against methicillin-sensitive Staphylococcus aureus NRS72 clinical isolate after 20 hrs by broth microdilution method | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10 | Second-Generation Phenylthiazole Antibiotics with Enhanced Pharmacokinetic Properties. |
| AID283155 | Antimicrobial susceptibility of Staphylococcus lugdunensis IDRL856 biofilms after 24 hrs assessed as bacterial regrowth | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | In vitro effects of antimicrobial agents on planktonic and biofilm forms of Staphylococcus lugdunensis clinical isolates. |
| AID1151767 | Antibacterial activity against vancomycin-sensitive Enterococcus faecalis ATCC 29212 in po dosed mouse systemic infection model | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID717209 | Antimicrobial activity against methicillin-sensitive Staphylococcus aureus CCARM 0204 incubated for 24 hrs by microtiter broth dilution method | 2012 | Journal of natural products, Dec-28, Volume: 75, Issue:12 | Antibacterial butenolides from the Korean tunicate Pseudodistoma antinboja. |
| AID533635 | Antimicrobial activity against Propionibacterium sp. by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activities of doripenem, a new broad-spectrum carbapenem, against recently collected clinical anaerobic isolates, with emphasis on the Bacteroides fragilis group. |
| AID572023 | Antibacterial activity against Sutterella wadsworthensis by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID1609266 | Antibacterial activity against Listeria monocytogenes ATCC 19111 after 18 to 20 hrs by CLSI-based broth microdilution assay | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Phenylthiazoles with nitrogenous side chain: An approach to overcome molecular obesity. |
| AID558495 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus 540 measured on day 15 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID1853459 | Bactericidal activity against methicillin-resistant Staphylococcus aureus ATCC 33592 assessed as reduction in colony forming unit incubated for 20 hrs | 2021 | RSC medicinal chemistry, Nov-17, Volume: 12, Issue:11 | SF |
| AID562626 | Antimicrobial activity against Group B Streptococcus by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | In vitro activities of three new dihydrofolate reductase inhibitors against clinical isolates of gram-positive bacteria. |
| AID552832 | Antibacterial activity against methicillin-sensitive Staphylococcus epidermidis | 2011 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1 | The discovery and structure-activity relationships leading to CE-156811, a difluorophenyl cyclopropyl fluoroether: a novel potent antibacterial analog derived from hygromycin A. |
| AID1329447 | Antibacterial activity against linezolid-resistant Mycobacterium tuberculosis H37Rv in hollow-fiber infection model assessed as reduction in bacterial burden at 1116 mg, po at 24 hrs dose regimen measured after 3 weeks | 2016 | Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24 | From lead optimization to NDA approval for a new antimicrobial: Use of pre-clinical effect models and pharmacokinetic/pharmacodynamic mathematical modeling. |
| AID542691 | fT>MIC in Bacillus anthracis infected in vitro hollow fiber PK/PD model at simulated dose of 400 mg administered every 24 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID562616 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | In vitro activities of three new dihydrofolate reductase inhibitors against clinical isolates of gram-positive bacteria. |
| AID283392 | Antimicrobial activity against Nocardia otitidiscaviarum after 72 hrs by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | In vitro activities of tigecycline and eight other antimicrobials against different Nocardia species identified by molecular methods. |
| AID573872 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus ATCC 13709 infected in iv dosed Swiss Webster mouse administered at 1 to 3 hrs post infection measured after 3 days | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | In vivo activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. |
| AID340858 | Antimicrobial activity against wild type vancomycin-intermediate resistant Staphylococcus aureus Mu50 by microdilution assay | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Interaction of the GraRS two-component system with the VraFG ABC transporter to support vancomycin-intermediate resistance in Staphylococcus aureus. |
| AID373840 | Antimicrobial activity against vancomycin-resistant Staphylococcus aureus 509 Michigan after 20 passages with daptomycin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID528842 | Antimicrobial activity against penicillin-resistant Streptococcus pneumoniae isolated from ICU patient blood assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID571823 | Antibacterial activity against Catenibacterium mitsuokai by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID285327 | Antimicrobial activity against vancomycin-susceptible Enterococcus faecalis ATCC 29212 | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | In vitro activity of aurein 1.2 alone and in combination with antibiotics against gram-positive nosocomial cocci. |
| AID558519 | Antimicrobial activity against heterogeneous vancomycin-intermediate Staphylococcus aureus 168 measured on day 30 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID565481 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro bactericidal activity of iclaprim in human plasma. |
| AID387460 | Cmax in Swiss albino mouse at 10 mg/kg, po | 2008 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 18, Issue:18 | Novel and potent oxazolidinone antibacterials featuring 3-indolylglyoxamide substituents. |
| AID573131 | Antibacterial activity against erythromycin-susceptible Streptococcus pyogenes by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID1076830 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 33591 assessed as growth inhibition after 18 hrs by broth microdilution method | 2014 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 24, Issue:6 | Discovery of novel bis-oxazolidinone compounds as potential potent and selective antitubercular agents. |
| AID555298 | Antibacterial activity against Tmp-susceptible coagulase-negative Staphylococcus aureus by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Antistaphylococcal activity of dihydrophthalazine antifolates, a family of novel antibacterial drugs. |
| AID525127 | Suppression of drug resistance development in recA-deficient Staphylococcus aureus KB103 assessed as prolonged length of subculture to develop Linezolid resistance at 4 times MIC and 0.25 times IC50 after 20 days | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Delayed development of linezolid resistance in Staphylococcus aureus following exposure to low levels of antimicrobial agents. |
| AID206098 | In vitro antibacterial activity against Streptococcus | 2003 | Bioorganic & medicinal chemistry letters, Jul-21, Volume: 13, Issue:14 | Synthesis and antibacterial activity of oxazolidinone containing sulphonyl group. |
| AID575272 | Antimicrobial activity against penicillin-intermediate Streptococcus pneumoniae by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Comparative in vitro activity profiles of novel bis-indole antibacterials against gram-positive and gram-negative clinical isolates. |
| AID541037 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 infected in Albino guiena pig assessed as no. of culture-negative cage fluid samples at 50 mg/kg measured on day 4 postinfection | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Linezolid alone or combined with rifampin against methicillin-resistant Staphylococcus aureus in experimental foreign-body infection. |
| AID565752 | Antimicrobial activity against Enterococcus faecalis clinical isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID352927 | Antibacterial activity against Streptococcus agalactiae ATCC 2901 after 18 to 20 hrs by agar dilution method | 2009 | Bioorganic & medicinal chemistry letters, May-01, Volume: 19, Issue:9 | Synthesis and antibacterial activities of novel oxazolidinones having spiro[2,4]heptane moieties. |
| AID565754 | Antimicrobial activity against oxacillin-susceptible Staphylococcus haemolyticus clinical isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID520030 | Antimicrobial activity against Enterococcus faecium A6349 harboring G2576U mutation in 23S rRNA | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID1493801 | Antibacterial activity against Staphylococcus aureus RN4220 NRS107 clinical isolate after 20 hrs by broth microdilution method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Biphenylthiazole antibiotics with an oxadiazole linker: An approach to improve physicochemical properties and oral bioavailability. |
| AID555296 | Antibacterial activity against methicillin-susceptible coagulase-negative Staphylococcus aureus by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Antistaphylococcal activity of dihydrophthalazine antifolates, a family of novel antibacterial drugs. |
| AID1680069 | Antibacterial activity against carbapenem-resistant Klebsiella pneumoniae clinical isolate 1 assessed as reduction in bacterial growth incubated for 16 to 20 hrs by CLSI-based broth microdilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Synthesis and antibacterial bioactivities of cationic deacetyl linezolid amphiphiles. |
| AID285064 | Antimicrobial activity against beta hemolytic Streptococci group F at 2 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID552831 | Antibacterial activity against glycopeptide-intermediate Staphylococcus aureus | 2011 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1 | The discovery and structure-activity relationships leading to CE-156811, a difluorophenyl cyclopropyl fluoroether: a novel potent antibacterial analog derived from hygromycin A. |
| AID558485 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus 540 measured on day 10 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID571998 | Antibacterial activity against Streptococcus anginosus by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID560499 | Antimicrobial activity against SCCmec type III vancomycin-intermediate Staphylococcus aureus isolate 5zjsau3 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID449616 | Antibacterial activity against methicillin-resistant Staphylococcus aureus by agar dilution method | 2009 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 19, Issue:18 | Water-soluble phosphate prodrugs of pleuromutilin analogues with potent in vivo antibacterial activity against Gram-positive pathogens. |
| AID528729 | Antibacterial activity against multidrug-resistant Streptococcus pneumoniae clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID303911 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after 24 hrs by agar dilution method | 2007 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 17, Issue:24 | Synthesis and antibacterial activity of potent heterocyclic oxazolidinones and the identification of RBx 8700. |
| AID583201 | Antimicrobial activity against vancomycin-intermediate Staphylococcus haemolyticus after 24 hrs by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | In vitro activity of the new multivalent glycopeptide-cephalosporin antibiotic TD-1792 against vancomycin-nonsusceptible Staphylococcus isolates. |
| AID1151752 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus isolate 15 | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID1375988 | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv measured after 1 week | 2016 | MedChemComm, Nov-01, Volume: 7, Issue:11 | SAR and identification of 2-(quinolin-4-yloxy)acetamides as |
| AID523776 | Antimicrobial activity against linezolid-susceptible Staphylococcus aureus by CLSI method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative activities of TR-700 (torezolid) against staphylococcal blood isolates collected in Spain. |
| AID519088 | Antimicrobial activity against Staphylococcus aureus KM164-165 harboring Gly155Arg mutation in rplC gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Linezolid and tiamulin cross-resistance in Staphylococcus aureus mediated by point mutations in the peptidyl transferase center. |
| AID583878 | Antibacterial activity against laboratory-derived Staphylococcus aureus ATCC 29213 harboring cfr-containing p42262 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Elevated linezolid resistance in clinical cfr-positive Staphylococcus aureus isolates is associated with co-occurring mutations in ribosomal protein L3. |
| AID717211 | Antimicrobial activity against methicillin-sensitive Staphylococcus aureus CCARM 3640 incubated for 24 hrs by microtiter broth dilution method | 2012 | Journal of natural products, Dec-28, Volume: 75, Issue:12 | Antibacterial butenolides from the Korean tunicate Pseudodistoma antinboja. |
| AID1151716 | Antibacterial activity against Staphylococcus saprophyticus | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID353061 | Antibacterial activity against vancomycin-resistant Enterococcus 4 after 18 to 20 hrs by agar dilution method | 2009 | Bioorganic & medicinal chemistry letters, May-01, Volume: 19, Issue:9 | Synthesis and antibacterial activities of novel oxazolidinones having spiro[2,4]heptane moieties. |
| AID541835 | Antimicrobial activity against Streptococcus agalactiae clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID1778654 | Antibacterial activity against penicillin-resistant Staphylococcus epidermidis assessed as inhibition of bacterial growth measured by broth microdilution method | 2021 | European journal of medicinal chemistry, Oct-05, Volume: 221 | Design, synthesis and evaluation of novel 9-arylalkyl-10-methylacridinium derivatives as highly potent FtsZ-targeting antibacterial agents. |
| AID753122 | Antibacterial activity against Bacillus subtilis MTCC 121 assessed as growth inhibition after 24 hrs by agar dilution method | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | Anti-tubercular agents. Part 7: a new class of diarylpyrrole-oxazolidinone conjugates as antimycobacterial agents. |
| AID577123 | Tmax in two-compartment pharmacokinetic/pharmacodynamic model at 800 mg, bid administered as 0.5 hr infusion over 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID30967 | Harmonic mean apparent terminal disposition half-life [t1/2beta (h)] in Male Sprague-Dawley Rat at dose 10 (mg/kg iv) | 2003 | Journal of medicinal chemistry, Jan-16, Volume: 46, Issue:2 | Identification of phenylisoxazolines as novel and viable antibacterial agents active against Gram-positive pathogens. |
| AID326504 | Cmax in Enterococcus faecalis infected Wistar rat at single administration of 600 mg, po | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Single-dose oral amoxicillin or linezolid for prophylaxis of experimental endocarditis due to vancomycin-susceptible and vancomycin-resistant Enterococcus faecalis. |
| AID558719 | Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus 555 measured on day 45 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID584116 | Ratio of MIC for Escherichia coli KAM32 harboring cloned pSP72 lmrS to MIC for Escherichia coli KAM32 harboring pSP72 | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | LmrS is a multidrug efflux pump of the major facilitator superfamily from Staphylococcus aureus. |
| AID763979 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae after 18 hrs by NCCLS agar dilution method | 2013 | European journal of medicinal chemistry, Aug, Volume: 66 | Synthesis and antibacterial activities of N-substituted-glycinyl 1H-1,2,3-triazolyl oxazolidinones. |
| AID1193405 | Antimicrobial activity against methicillin-sensitive Staphylococcus aureus ATCC 29213 measured after overnight incubation | 2015 | Bioorganic & medicinal chemistry, Apr-01, Volume: 23, Issue:7 | Identification of Bacillus anthracis PurE inhibitors with antimicrobial activity. |
| AID1519053 | Inhibition of recombinant human MAO-A (active motif 31502) at 30 uM using luciferin as substrate incubated for 15 mins followed by substrate addition and measured after 60 mins by luminescence based method relative to control | 2020 | European journal of medicinal chemistry, Jan-01, Volume: 185 | Optimization of biaryloxazolidinone as promising antibacterial agents against antibiotic-susceptible and antibiotic-resistant gram-positive bacteria. |
| AID531555 | Antibacterial activity against coagulase-negative Staphylococcus haemolyticus obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID1151719 | Bacteriostatic activity against vancomycin-sensitive Enterococcus faecalis | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID1337721 | Antibacterial activity against Staphylococcus aureus ATCC 29213 after 18 to 24 hrs by broth microdilution method | 2016 | European journal of medicinal chemistry, Nov-29, Volume: 124 | New isoxazolidinone and 3,4-dehydro-β-proline derivatives as antibacterial agents and MAO-inhibitors: A complex balance between two activities. |
| AID1778664 | Ratio of MBC to MIC against erythromycin-susceptible Staphylococcus aureus ATCC 25923 | 2021 | European journal of medicinal chemistry, Oct-05, Volume: 221 | Design, synthesis and evaluation of novel 9-arylalkyl-10-methylacridinium derivatives as highly potent FtsZ-targeting antibacterial agents. |
| AID1193404 | Antimicrobial activity against Yersinia pestis BEI/ATCC A1122 measured after overnight incubation | 2015 | Bioorganic & medicinal chemistry, Apr-01, Volume: 23, Issue:7 | Identification of Bacillus anthracis PurE inhibitors with antimicrobial activity. |
| AID1591543 | Antibacterial activity against Staphylococcus aureus clinical isolate incubated for 24 hrs by CLSI protocol based broth microdilution method | 2019 | Bioorganic & medicinal chemistry, 07-15, Volume: 27, Issue:14 | Discovery of 1,3,4-oxadiazol-2-one-containing benzamide derivatives targeting FtsZ as highly potent agents of killing a variety of MDR bacteria strains. |
| AID524955 | Antibacterial activity against methicillin-resistant coagulase-negative Staphylococcus capitis clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Comparative surveillance study of telavancin activity against recently collected gram-positive clinical isolates from across the United States. |
| AID278915 | Antibacterial activity against linezolid-susceptible Enterococcus faecalis | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | In vitro antibacterial activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. |
| AID523794 | Antimicrobial activity against oxacillin-susceptible coagulase-negative Staphylococcus aureus assessed as percent susceptible strain by CLSI method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative activities of TR-700 (torezolid) against staphylococcal blood isolates collected in Spain. |
| AID542917 | Antimicrobial activity against Bacillus anthracis infected in in vitro hollow fiber PK/PD model assessed as cell killing at 800 mg administered as 4 divided doses every 6 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID576136 | Antibacterial activity against 10'4 to 10'5 CFU Enterococcus faecalis after 18 hrs by CLSI 2-fold agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | In vitro and in vivo activities of LCB01-0371, a new oxazolidinone. |
| AID207015 | Antibacterial activity against linezolid-resistant Staphylococcus aureus (SA1012 LinR) | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | Novel oxazolidinone-quinolone hybrid antimicrobials. |
| AID1879692 | Antimycobacterial activity against PAS resistant Mycobacterium tuberculosis H37Rv harboring E153A mutant assessed as inhibition of bacterial growth measured after 2 weeks by microbroth dilution method | 2022 | European journal of medicinal chemistry, Mar-15, Volume: 232 | Synthesis and biological evaluation of orally active prodrugs and analogs of para-aminosalicylic acid (PAS). |
| AID533942 | Antimicrobial activity against linezolid-resistant Enterococcus faecalis 413 harboring G2576U mutation in peptidyl transferase centre by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains. |
| AID284969 | Antimicrobial activity against Corynebacterium jeikeium at 0.5 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID1434679 | Anti-bacterial activity against methicillin-resistant Staphylococcus aureus CCARM 3089 by 2-fold microtiter broth dilution method | 2017 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 27, Issue:3 | Cadiolides J-M, antibacterial polyphenyl butenolides from the Korean tunicate Pseudodistoma antinboja. |
| AID576860 | Bactericidal activity against 13 hrs peripheral compartment culture samples of Enterococcus faecalis Ef1497 in two-compartment pharmacokinetic/pharmacodynamic model assessed as effect on bacterial count at 800 mg, bid administered as 0.5 hr infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID572013 | Antibacterial activity against Prevotella corporis by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID576879 | Bactericidal activity against 14 hrs peripheral compartment culture samples of Enterococcus faecalis Ef1497 MutM3 in two-compartment pharmacokinetic/pharmacodynamic model assessed as effect on bacterial count at 600 mg, bid administered as 0.5 hr infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID1367595 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus ATCC 29213 by CLSI broth microdilution method | 2017 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23 | Compound design guidelines for evading the efflux and permeation barriers of Escherichia coli with the oxazolidinone class of antibacterials: Test case for a general approach to improving whole cell Gram-negative activity. |
| AID533659 | Antimicrobial activity against Staphylococcus aureus RN4220 | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic characterization of Vga ABC proteins conferring reduced susceptibility to pleuromutilins in Staphylococcus aureus. |
| AID244929 | Antibacterial activity against Streptococcus pyogenes G-36 was determined | 2004 | Bioorganic & medicinal chemistry letters, Oct-18, Volume: 14, Issue:20 | Synthesis and antibacterial activity of novel 6-fluoro-1-[(1R,2S)-2-fluorocyclopropan-1-yl]-4-oxoquinoline-3-carboxylic acids bearing cyclopropane-fused 2-amino-8-azabicyclo[4.3.0]nonan-8-yl substituents at the C-7 position. |
| AID458451 | Antimicrobial activity against Micrococcus luteus ATCC 10240 at 2 mM after overnight incubation by agar diffusion method | 2010 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 20, Issue:3 | Syntheses and antibacterial activity studies of new oxazolidinones from nitroso Diels-Alder chemistry. |
| AID542701 | fCmax in Bacillus anthracis infected in vitro hollow fiber PK/PD model at simulated dose of 600 mg /day administered as 6 divided doses every 4 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID404937 | Antibacterial activity against methicillin-susceptible coagulase-negative Staphylococcus sp. by CLSI dilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro activities of CG400549, a novel FabI inhibitor, against recently isolated clinical staphylococcal strains in Korea. |
| AID1446760 | Antibacterial activity against vancomycin-resistant Staphylococcus aureus VRSA4 after 20 hrs by broth microdilution method | 2017 | European journal of medicinal chemistry, Apr-21, Volume: 130 | Diphenylurea derivatives for combating methicillin- and vancomycin-resistant Staphylococcus aureus. |
| AID1594373 | Antibacterial activity against Klebsiella pneumoniae ATCC BAA-1705 after 18 to 24 hrs in presence of colistin by broth microdilution assay | 2019 | Bioorganic & medicinal chemistry, 05-01, Volume: 27, Issue:9 | Second-generation aryl isonitrile compounds targeting multidrug-resistant Staphylococcus aureus. |
| AID244815 | Minimum inhibitory concentration against Staphylococcus aureus A15090 | 2005 | Bioorganic & medicinal chemistry letters, Jun-02, Volume: 15, Issue:11 | Synthesis and antibacterial activity of dihydro-1,2-oxazine and 2-pyrazoline oxazolidinones: novel analogs of linezolid. |
| AID775549 | Antibacterial activity against Staphylococcus aureus Smith assessed as growth inhibition by broth microdilution method | 2013 | European journal of medicinal chemistry, Nov, Volume: 69 | Synthesis and in vitro/in vivo antibacterial activity of oxazolidinones having thiocarbamate at C-5 on the A-ring and an amide- or urea-substituted [1,2,5]triazepane or [1,2,5]oxadiazepane as the C-ring. |
| AID206312 | In vitro antibacterial activity against Staphylococcus aureus strains UC12673, UC9213, ATCC 29213, and UC9271 (SA); range is 2-4 | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | New antibacterial tetrahydro-4(2H)-thiopyran and thiomorpholine S-oxide and S,S-dioxide phenyloxazolidinones. |
| AID524985 | Antibacterial activity against penicillin intermediate Streptococcus pneumoniae clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Comparative surveillance study of telavancin activity against recently collected gram-positive clinical isolates from across the United States. |
| AID637980 | Antibacterial activity against Staphylococcus aureus ATCC 13709 after overnight incubation by twofold broth dilution technique | 2012 | Bioorganic & medicinal chemistry, Jan-01, Volume: 20, Issue:1 | Efficient microwave-assisted synthesis, antibacterial activity and high fluorescence of 5 benzimidazolyl-2'-deoxyuridines. |
| AID409582 | Antimicrobial activity against Enterococcus faecalis after 16 to 18 hrs by agar dilution method | 2008 | European journal of medicinal chemistry, Aug, Volume: 43, Issue:8 | Synthesis and biological evaluation of new N-linked 5-triazolylmethyl oxazolidinones. |
| AID560498 | Antimicrobial activity against vancomycin-susceptible Staphylococcus aureus assessed as growth inhibition at 16 times MIC | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID285159 | Antimicrobial activity against non replicating persistence Mycobacterium tuberculosis H37Rv in aerobic condition assessed by relative light units after 7 days | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Low-oxygen-recovery assay for high-throughput screening of compounds against nonreplicating Mycobacterium tuberculosis. |
| AID370037 | Antibacterial activity against methicillin-resistant Staphylococcus aureus COL infected in po dosed DBA/2 mouse localized infection model assessed as log reduction in CFU per gram of thigh at 5 mg/kg, iv administered 2 hrs postinfection thrice daily for 1 | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vivo efficacy of a novel oxazolidinone compound in two mouse models of infection. |
| AID1852690 | Antibacterial activity against efflux pump lacking/recombinant OM pore producing Pseudomonas aeruginosa incubated for 24 hrs by twofold serial dilution method | |||
| AID285006 | Antimicrobial activity against Enterococcus gallinarum at 4 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID535257 | Antimicrobial activity against vancomycin resistant Staphylococcus aureus VRS-5 expressing SCCmec type 2 element by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | In vitro activity of ceftaroline against community-associated methicillin-resistant, vancomycin-intermediate, vancomycin-resistant, and daptomycin-nonsusceptible Staphylococcus aureus isolates. |
| AID1687311 | Antibacterial activity against wild type Escherichia coli BW25113 incubated for 18 to 20 hrs by broth microdilution method | 2020 | European journal of medicinal chemistry, Jan-15, Volume: 186 | Development of benzimidazole-based derivatives as antimicrobial agents and their synergistic effect with colistin against gram-negative bacteria. |
| AID373649 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus by agar dilution CLSI method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID734687 | Antibacterial activity against Escherichia coli MTCC 739 at 20 ug/ml after 24 hrs by disk diffusion method | 2013 | European journal of medicinal chemistry, Apr, Volume: 62 | Synthesis, biological evaluation of new oxazolidino-sulfonamides as potential antimicrobial agents. |
| AID1395972 | Antibacterial activity against methicillin-resistant Staphylococcus aureus 2 after 16 to 18 hrs by broth microdilution method | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9 | An Efficient Buchwald-Hartwig/Reductive Cyclization for the Scaffold Diversification of Halogenated Phenazines: Potent Antibacterial Targeting, Biofilm Eradication, and Prodrug Exploration. |
| AID560828 | AUC (0 to 24 hrs) in human adults with pulmonary tuberculosis at 600 mg administered twice daily for 5 days | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Population pharmacokinetics of linezolid in adults with pulmonary tuberculosis. |
| AID581019 | Inhibition of DNA synthesis in Staphylococcus aureus ATCC 25923 assessed as incorporation of [3H]thymidine at 2 ug/ml by liquid scintillation counter | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Mode of action of Ranbezolid against staphylococci and structural modeling studies of its interaction with ribosomes. |
| AID564097 | Bactericidal activity against stationary-phase methicillin-resistant Staphylococcus aureus HUSA 304 after 24 hrs by time kill analysis in presence of 50 mg/L calcium ions | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | Efficacy of high doses of daptomycin versus alternative therapies against experimental foreign-body infection by methicillin-resistant Staphylococcus aureus. |
| AID409579 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus after 16 to 18 hrs by agar dilution method | 2008 | European journal of medicinal chemistry, Aug, Volume: 43, Issue:8 | Synthesis and biological evaluation of new N-linked 5-triazolylmethyl oxazolidinones. |
| AID1311368 | Antibacterial activity against Mycobacterium tuberculosis 124R measured after 14 days by broth microdilution assay | 2016 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15 | An evolved oxazolidinone with selective potency against Mycobacterium tuberculosis and gram positive bacteria. |
| AID499163 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus Smith OC 4172 infected in SKH1 mouse assessed as log change in bacterial colony forming unit per gram of skin tissue at 25 mg/kg/day, po (Rvb = 1.6 deltalog CFU) | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vivo activity of ceftobiprole in murine skin infections due to Staphylococcus aureus and Pseudomonas aeruginosa. |
| AID558469 | Antimicrobial activity against vancomycin-resistant Staphylococcus aureus 509 measured after 10 antibiotic-free subculturing by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID303967 | Bacteriostatic activity against Enterococcus after 48 hrs by time kill study | 2007 | Journal of medicinal chemistry, Nov-29, Volume: 50, Issue:24 | Antibacterial oxazolidinones possessing a novel C-5 side chain. (5R)-trans-3-[3-Fluoro-4- (1-oxotetrahydrothiopyran-4-yl)phenyl]-2- oxooxazolidine-5-carboxylic acid amide (PF-00422602), a new lead compound. |
| AID524951 | Antibacterial activity against methicillin-susceptible coagulase-negative Staphylococcus simulans clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Comparative surveillance study of telavancin activity against recently collected gram-positive clinical isolates from across the United States. |
| AID555301 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus 505 by broth macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Antistaphylococcal activity of dihydrophthalazine antifolates, a family of novel antibacterial drugs. |
| AID1879690 | Antimycobacterial activity against multidrug resistant Mycobacterium tuberculosis H37Rv assessed as inhibition of bacterial growth measured after 2 weeks by microbroth dilution method | 2022 | European journal of medicinal chemistry, Mar-15, Volume: 232 | Synthesis and biological evaluation of orally active prodrugs and analogs of para-aminosalicylic acid (PAS). |
| AID283394 | Antimicrobial activity against Nocardia beijingensis after 72 hrs by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | In vitro activities of tigecycline and eight other antimicrobials against different Nocardia species identified by molecular methods. |
| AID410202 | Antibacterial activity against methicillin-resistant Staphylococcus aureus by broth micro dilution method | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24 | A facile synthesis, antibacterial, and antitubercular studies of some piperidin-4-one and tetrahydropyridine derivatives. |
| AID524685 | Antibacterial activity against vancomycin-susceptible Enterococcus faecalis clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro antibacterial activity of CE-156811, a novel analog derived from hygromycin A. |
| AID285342 | Antibacterial activity against community acquired methicillin-resistant Staphylococcus aureus HT20020488 in Mueller-Hinton medium | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Effect of antibiotics on Staphylococcus aureus producing Panton-Valentine leukocidin. |
| AID429063 | Antiplasmodial activity after 48 hrs against Plasmodium falciparum 3D7 as Malstat LDH activity | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Telithromycin and quinupristin-dalfopristin induce delayed death in Plasmodium falciparum. |
| AID571832 | Antibacterial activity against Ruminococcus albus by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID1904085 | Antibacterial activity against Escherichia coli MG1655 | 2022 | European journal of medicinal chemistry, Apr-05, Volume: 233 | Alternative approaches utilizing click chemistry to develop next-generation analogs of solithromycin. |
| AID558477 | Antimicrobial activity against vancomycin-resistant Staphylococcus aureus 510 measured on day 5 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID522910 | Antibacterial activity against hospital-acquired methicillin-resistant Staphylococcus aureus isolate 1751 after 24 hrs by modified broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Antistaphylococcal activity of ACHN-490 tested alone and in combination with other agents by time-kill assay. |
| AID576885 | Ratio of Cmax to MIC for 12.5 hrs peripheral compartment culture samples of Staphylococcus aureus RN4220 MutS2 in two-compartment pharmacokinetic/pharmacodynamic model at 600 mg, bid administered as 0.5 hr infusion for 2 days | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID1327099 | Antibacterial activity against Escherichia coli NCIM 2688 measured after 8 hrs by spectrophotometric method | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Design, synthesis and biological evaluation of novel azaspiro analogs of linezolid as antibacterial and antitubercular agents. |
| AID532782 | Antibacterial activity against vancomycin-susceptible Staphylococcus aureus NJ after 24 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Improved antimicrobial activity of linezolid against vancomycin-intermediate Staphylococcus aureus. |
| AID572008 | Antibacterial activity against Bilophila wadsworthia by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID524683 | Antibacterial activity against methicillin-susceptible Staphylococcus epidermidis clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro antibacterial activity of CE-156811, a novel analog derived from hygromycin A. |
| AID548741 | Antimicrobial activity against Vancomycin-susceptible Enterococcus faecalis assessed as percent susceptible isolate by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Activities of dalbavancin against a worldwide collection of 81,673 gram-positive bacterial isolates. |
| AID285355 | Decrease in Panton-Valentine leukocidin level in community acquired methicillin-resistant Staphylococcus aureus HT20030203 in CYY medium | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Effect of antibiotics on Staphylococcus aureus producing Panton-Valentine leukocidin. |
| AID528847 | Antimicrobial activity against methicillin-resistant Staphylococcus epidermidis isolated from ICU patient blood assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID535773 | Antimicrobial activity against Mycobacterium ulcerans 1059 harboring pTY60K carrying the luxAB gene under the hsp60 promoter agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Rapid assessment of antibacterial activity against Mycobacterium ulcerans by using recombinant luminescent strains. |
| AID590153 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus Smith infected po dosed ICR mouse assessed as protection against mouse mortality administered 1 hr after infection measured up to 7 days | 2011 | European journal of medicinal chemistry, Apr, Volume: 46, Issue:4 | Discovery of torezolid as a novel 5-hydroxymethyl-oxazolidinone antibacterial agent. |
| AID561086 | Antibacterial activity against Streptococcus pyogenes by CLSI M7-A7 broth microdilution broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | In vitro activity of TR-700, the active ingredient of the antibacterial prodrug TR-701, a novel oxazolidinone antibacterial agent. |
| AID542685 | fAUC (24 hrs) in Bacillus anthracis infected in vitro hollow fiber PK/PD model at simulated dose of 600 mg administered every 24 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID581042 | Ratio of IC50 for mammalian ribosomal activity to ribosomal activity in Escherichia coli S30 by coupled transcription/translation assay | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Mode of action of Ranbezolid against staphylococci and structural modeling studies of its interaction with ribosomes. |
| AID533755 | Antimicrobial activity against hospital acquired methicillin-resistant Staphylococcus aureus SA238 after 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Cellular pharmacodynamics of the novel biaryloxazolidinone radezolid: studies with infected phagocytic and nonphagocytic cells, using Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Legionella pneumophila. |
| AID577112 | ABBC (0 to 24 hrs) in Enterococcus faecalis ATCC 29212 in two-compartment pharmacokinetic/pharmacodynamic model at 200 mg, bid administered as 0.5 hr infusion for 2 days | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID558511 | Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus 555 measured on day 25 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID308727 | Antibacterial activity against Streptococcus pneumoniae SV1 SP3 by micro-broth method | 2007 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 17, Issue:16 | Synthesis and SAR of novel conformationally-restricted oxazolidinones possessing gram-positive and fastidious gram-negative antibacterial activity. Part 1: Substituted pyrazoles. |
| AID576133 | Antibacterial activity against 10'4 to 10'5 CFU Moraxella catarrhalis after 18 hrs by CLSI 2-fold agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | In vitro and in vivo activities of LCB01-0371, a new oxazolidinone. |
| AID565019 | Bactericidal activity against methicillin-susceptible coagulase-negative Staphylococcus sciuri after 24 hrs by plate counting method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID630564 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 33591 infected in NSA mouse neutropenic model administered orally 1 hour after infection measured 48 hrs post-treatment | 2011 | Journal of medicinal chemistry, Nov-10, Volume: 54, Issue:21 | Design, synthesis, and structure-activity relationship studies of highly potent novel benzoxazinyl-oxazolidinone antibacterial agents. |
| AID285060 | Antimicrobial activity against beta hemolytic Streptococci group F at 0.12 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID1139108 | Antimicrobial activity against Staphylococcus aureus in rat thigh assessed as log reduction of CFU at 30 mg/kg, iv after 8 hrs | 2014 | Bioorganic & medicinal chemistry letters, May-01, Volume: 24, Issue:9 | Successful application of serum shift prediction models to the design of dual targeting inhibitors of bacterial gyrase B and topoisomerase IV with improved in vivo efficacy. |
| AID1312950 | Bactericidal activity against methicillin-resistant Staphylococcus aureus USA300 NRS384 clinical isolate after 20 hrs by broth microdilution method | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10 | Second-Generation Phenylthiazole Antibiotics with Enhanced Pharmacokinetic Properties. |
| AID1710586 | Antibacterial activity against Staphylococcus epidermidis NRS101 assessed as inhibition of visible bacterial growth incubated for 18 to 20 hrs by CLSI method | 2020 | RSC medicinal chemistry, Jan-01, Volume: 11, Issue:1 | Potent trifluoromethoxy, trifluoromethylsulfonyl, trifluoromethylthio and pentafluorosulfanyl containing (1,3,4-oxadiazol-2-yl)benzamides against drug-resistant Gram-positive bacteria. |
| AID565003 | Bactericidal activity against methicillin-susceptible coagulase-negative Staphylococcus hominis after 24 hrs by plate counting method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID1778653 | Antibacterial activity against Staphylococcus aureus assessed as inhibition of bacterial growth measured by broth microdilution method | 2021 | European journal of medicinal chemistry, Oct-05, Volume: 221 | Design, synthesis and evaluation of novel 9-arylalkyl-10-methylacridinium derivatives as highly potent FtsZ-targeting antibacterial agents. |
| AID285147 | Antimicrobial activity against viridans group Streptococcus gordonii by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID1154476 | Antibacterial activity against of methicillin-resistant Staphylococcus aureus ATCC 33591 infected in iv dosed neutropenic mouse administered 1 hr after infection measured after 24 hrs | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | Design, synthesis, and structure-activity relationship studies of novel thioether pleuromutilin derivatives as potent antibacterial agents. |
| AID1873892 | Antibacterial activity against Staphylococcus aureus ATCC 29213 incubated for 16 to 20 hrs using 10^3 CFU/ml bacterial inoculum by broth microdilution method | 2022 | European journal of medicinal chemistry, Aug-05, Volume: 238 | Design, synthesis and activity against drug-resistant bacteria evaluation of C-20, C-23 modified 5-O-mycaminosyltylonolide derivatives. |
| AID584114 | Antibacterial activity against Escherichia coli KAM32 harboring Staphylococcus aureus cloned pSP72 lmrS by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | LmrS is a multidrug efflux pump of the major facilitator superfamily from Staphylococcus aureus. |
| AID561090 | Antibacterial activity against Bacteroides fragilis by CLSI M11-A7 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | In vitro activity of TR-700, the active ingredient of the antibacterial prodrug TR-701, a novel oxazolidinone antibacterial agent. |
| AID406623 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae isolates assessed as percent resistant isolates by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Prevalence, characteristics, and molecular epidemiology of macrolide and fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae at five tertiary-care hospitals in Korea. |
| AID1677798 | Bactericidal activity against penicillin-resistant Staphylococcus aureus assessed as reduction in number of colony forming units incubated for 24 hrs followed by re-plating and reincubation on tryptic soy agar plate for 24 hrs | 2020 | Bioorganic & medicinal chemistry, 11-01, Volume: 28, Issue:21 | Design, synthesis of novel 4,5-dihydroisoxazole-containing benzamide derivatives as highly potent FtsZ inhibitors capable of killing a variety of MDR Staphylococcus aureus. |
| AID528735 | Antibacterial activity against methicillin resistant coagulase-negative Staphylococcus capitis clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID1197120 | Antibacterial activity against vancomycin/methicillin-resistant Staphylococcus aureus VRS2 clinical isolate after 16 to 20 hrs by broth microdilution method | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3 | Structure-activity relationship for the oxadiazole class of antibiotics. |
| AID687496 | Half life in rat | 2012 | Bioorganic & medicinal chemistry, Oct-15, Volume: 20, Issue:20 | Antitubercular nitrofuran isoxazolines with improved pharmacokinetic properties. |
| AID531551 | Antibacterial activity against Staphylococcus aureus obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID1603254 | Antibacterial activity against Mycobacterium tuberculosis H37Rv after 7 days by microplate alamar blue assay | |||
| AID449619 | Antibacterial activity against Streptococcus pneumoniae by agar dilution method | 2009 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 19, Issue:18 | Water-soluble phosphate prodrugs of pleuromutilin analogues with potent in vivo antibacterial activity against Gram-positive pathogens. |
| AID499168 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus OC 8525 infected in SKH1 mouse assessed as log change in bacterial colony forming unit per gram of skin tissue at 100 mg/kg/day, po (Rvb = 0.8 deltalog CFU) | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vivo activity of ceftobiprole in murine skin infections due to Staphylococcus aureus and Pseudomonas aeruginosa. |
| AID262229 | Antibacterial activity against Staphylococcus aureus ATCC 25923 | 2006 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 16, Issue:6 | Novel 4-N-substituted aryl pent-2-ene-1,4-dione derivatives of piperazinyloxazolidinones as antibacterials. |
| AID756095 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus assessed as growth inhibition after 16 hrs by agar dilution method | 2013 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 23, Issue:13 | Synthesis and biological evaluation of novel benzoxazinyl-oxazolidinones as potential antibacterial agents. |
| AID542703 | fAUC (24 hrs) in Bacillus anthracis infected in vitro hollow fiber PK/PD model at simulated dose of 500 mg /day administered once every 24 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID1151724 | Bactericidal activity against penicillin-sensitive Streptococcus pneumoniae | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID1873908 | Antibacterial activity against Cronobacter sakazakii ATCC 29544 incubated for 16 to 20 hrs by broth microdilution method | 2022 | European journal of medicinal chemistry, Aug-05, Volume: 238 | Design, synthesis and activity against drug-resistant bacteria evaluation of C-20, C-23 modified 5-O-mycaminosyltylonolide derivatives. |
| AID545813 | Antimicrobial activity against vancomycin-resistant Staphylococcus aureus isolate VRS5 assessed as inhibition of biofilm formation after 24 hrs by by serial dilution method in presence of 0.002% polysorbate 80 | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Oritavancin kills stationary-phase and biofilm Staphylococcus aureus cells in vitro. |
| AID285118 | Antimicrobial activity against viridans group Streptococcus oralis with G2576T rRNA mutation at 4 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID523801 | Antimicrobial activity against linezolid-susceptible Staphylococcus aureus assessed as inhibition of microbial growth at 1 ug/ml by CLSI method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative activities of TR-700 (torezolid) against staphylococcal blood isolates collected in Spain. |
| AID1770341 | Antibacterial activity against erythromycin-susceptible Staphylococcus aureus ATCC 25923 assessed as inhibition of bacterial growth measured after 20 hrs by two-fold microdilution assay | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Modification of 5-methylphenanthridium from benzothiazoles to indoles as potent FtsZ inhibitors: Broadening the antibacterial spectrum toward vancomycin-resistant enterococci. |
| AID519986 | Antimicrobial activity against Streptococcus pneumoniae nosocomial isolate | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID519996 | Antimicrobial activity against Streptococcus pneumoniae harboring mef(A) gene | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID1687316 | Antibacterial activity against Pseudomonas aeruginosa ATCC 15442 incubated for 18 to 20 hrs by broth microdilution method | 2020 | European journal of medicinal chemistry, Jan-15, Volume: 186 | Development of benzimidazole-based derivatives as antimicrobial agents and their synergistic effect with colistin against gram-negative bacteria. |
| AID1446756 | Antibacterial activity against methicillin-resistant Staphylococcus aureus USA200 NRS383 clinical isolate after 20 hrs by broth microdilution method | 2017 | European journal of medicinal chemistry, Apr-21, Volume: 130 | Diphenylurea derivatives for combating methicillin- and vancomycin-resistant Staphylococcus aureus. |
| AID1879693 | Antimycobacterial activity against PAS resistant Mycobacterium tuberculosis H37Rv harboring S150G mutant assessed as inhibition of bacterial growth measured after 2 weeks by microbroth dilution method | 2022 | European journal of medicinal chemistry, Mar-15, Volume: 232 | Synthesis and biological evaluation of orally active prodrugs and analogs of para-aminosalicylic acid (PAS). |
| AID285374 | Half life for simulated intermittent-dosage regimen at 120 mg every 12 hrs using in vitro PK/PD model | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Pharmacokinetic/pharmacodynamic factors influencing emergence of resistance to linezolid in an in vitro model. |
| AID1079942 | Steatosis, proven histopathologically. Value is number of references indexed. [column 'STEAT' in source] | |||
| AID41245 | Antibacterial activity against Bacteroides fragilis UC12199 | 1998 | Bioorganic & medicinal chemistry letters, May-19, Volume: 8, Issue:10 | Synthesis and antibacterial activity of [6,5,5] and [6,6,5] tricyclic fused oxazolidinones. |
| AID528973 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID573119 | Antibacterial activity against coagulase-negative and oxacillin-susceptible Staphylococcus aureus by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID1710574 | Antibacterial activity against methicillin-resistant Staphylococcus aureus NRS 119 assessed as inhibition of visible bacterial growth incubated for 18 to 20 hrs by CLSI method | 2020 | RSC medicinal chemistry, Jan-01, Volume: 11, Issue:1 | Potent trifluoromethoxy, trifluoromethylsulfonyl, trifluoromethylthio and pentafluorosulfanyl containing (1,3,4-oxadiazol-2-yl)benzamides against drug-resistant Gram-positive bacteria. |
| AID560797 | Absorption rate constant in human adults with pulmonary tuberculosis at 600 mg administered daily for 7 days | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Population pharmacokinetics of linezolid in adults with pulmonary tuberculosis. |
| AID1437031 | Antimycobacterial activity against isoniazid/rifampicin/kanamycin/streptomycin/ofloxacin/moxifloxacin/levofloxacin-resistant Mycobacterium tuberculosis by microplate Alamar Blue assay | 2017 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 27, Issue:4 | Development of gallic acid formazans as novel enoyl acyl carrier protein reductase inhibitors for the treatment of tuberculosis. |
| AID326284 | Antibacterial activity against methicillin-resistant Staphylococcus aureus 5004 at 4 hrs daily exposure for 1 day by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Comparative activities of daptomycin, linezolid, and tigecycline against catheter-related methicillin-resistant Staphylococcus bacteremic isolates embedded in biofilm. |
| AID373996 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus 547 after 21 passages with quinupristin-dalfopristin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID1400028 | Inhibition of protein translation/transcription in Escherichia coli S30 cell extract at 0.1 ug/ml using circular DNA with pBESTluc after 60 mins by luciferase reporter gene assay | 2018 | Bioorganic & medicinal chemistry, 09-15, Volume: 26, Issue:17 | An antimycobacterial pleuromutilin analogue effective against dormant bacilli. |
| AID571997 | Antibacterial activity against Peptostreptococcus micros by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID467835 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 70069 after 24 hrs by agar dilution method | 2009 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 19, Issue:23 | Novel 4-N-substituted aryl but-3-ene-1,2-dione derivatives of piperazinyloxazolidinones as antibacterial agents. |
| AID520006 | Antimicrobial activity against Chlamydia trachomatis isolated from human respiratory tract by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID555293 | Antibacterial activity against methicillin-resistant Staphylococcus aureus by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Antistaphylococcal activity of dihydrophthalazine antifolates, a family of novel antibacterial drugs. |
| AID524978 | Antibacterial activity against Streptococcus constellatus clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Comparative surveillance study of telavancin activity against recently collected gram-positive clinical isolates from across the United States. |
| AID565759 | Antimicrobial activity against oxacillin-resistant Staphylococcus aureus clinical isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID574953 | Antimicrobial activity against Streptococcus pneumoniae serotype 6C by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID520770 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus infected in New Zealand rabbit osteomyelitis model assessed as bacterial count per gram of tibial marrow at 60 mg/kg, po administered every 8 hrs for 4 weeks measured on week 8 pos | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Efficacies of ceftobiprole medocaril and comparators in a rabbit model of osteomyelitis due to methicillin-resistant Staphylococcus aureus. |
| AID522909 | Antibacterial activity against hospital-acquired methicillin-resistant Staphylococcus aureus isolate 1743 after 24 hrs by modified broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Antistaphylococcal activity of ACHN-490 tested alone and in combination with other agents by time-kill assay. |
| AID533954 | Antimicrobial activity against Legionella pneumophila ATCC 33153 after 48 hrs | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Cellular pharmacodynamics of the novel biaryloxazolidinone radezolid: studies with infected phagocytic and nonphagocytic cells, using Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Legionella pneumophila. |
| AID561257 | Antibacterial activity against Streptococcus agalactiae by CLSI M100-S17 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | AFN-1252, a FabI inhibitor, demonstrates a Staphylococcus-specific spectrum of activity. |
| AID1692899 | Antibacterial activity against hospital acquired methicillin-resistant Staphylococcus aureus clinical isolates | 2021 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 32 | Design, synthesis and antibacterial evaluation of novel oxazolidinone derivatives nitrogen-containing fused heterocyclic moiety. |
| AID1168006 | Antibacterial activity against vancomycin-resistant Enterococcus faecium clinical isolate 28/211 after overnight incubation by two-fold serial dilution method | 2014 | Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21 | Synthesis and biological evaluation of novel peptide BF2 as an antibacterial agent against clinical isolates of vancomycin-resistant enterococci. |
| AID1437033 | Antimycobacterial activity against isoniazid/rifampicin-resistant Mycobacterium tuberculosis by microplate Alamar Blue assay | 2017 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 27, Issue:4 | Development of gallic acid formazans as novel enoyl acyl carrier protein reductase inhibitors for the treatment of tuberculosis. |
| AID318356 | Antibacterial activity against vancomycin-intermediate resistant Staphylococcus aureus | 2007 | Proceedings of the National Academy of Sciences of the United States of America, May-01, Volume: 104, Issue:18 | Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties. |
| AID558492 | Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus 1287 measured on day 15 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID285072 | Antimicrobial activity against viridans group Streptococcus anginosus at 0.12 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID559287 | Antimicrobial activity against recombination-deficient Enterococcus faecalis JH2-2 recA harboring nucleotides at position 2576 in rrlA 2576G, rrlB 2576G, rrlC 2576T and rrlD 2576T after 7, 8, 9 passages under Linezolid selective pressure by agar dilution | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Influence of recombination on development of mutational resistance to linezolid in Enterococcus faecalis JH2-2. |
| AID285085 | Antimicrobial activity against viridans group Streptococcus constellatus at 0.25 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID1361100 | Bacteriostatic activity against methicillin-resistant Staphylococcus aureus USA500 NRS385 clinical isolate after 20 hrs by broth microdilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | N-(1,3,4-oxadiazol-2-yl)benzamide analogs, bacteriostatic agents against methicillin- and vancomycin-resistant bacteria. |
| AID1056341 | AUC (infinity) in ICR mouse at 67.7 mg/kg, po by LC-MS/MS analysis | 2013 | ACS medicinal chemistry letters, Nov-14, Volume: 4, Issue:11 | Potent oxazolidinone antibacterials with heteroaromatic C-ring substructure. |
| AID1519269 | Antibacterial activity agianst methicillin-resistant Staphylococcus aureus clinical isolates | 2019 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 29, Issue:23 | Synthesis and antibacterial evaluation of novel oxazolidinone derivatives containing a piperidinyl moiety. |
| AID1547710 | Antibacterial activity against vancomycin-resistant Staphylococcus aureus VRS2 clinical isolate by broth microdilution method | 2020 | ACS medicinal chemistry letters, Mar-12, Volume: 11, Issue:3 | Structure-Activity Relationship for the Oxadiazole Class of Antibacterials. |
| AID28087 | Cmax value in Male Sprague-Dawley Rat at dose 25 (mg/kg po) | 2003 | Journal of medicinal chemistry, Jan-16, Volume: 46, Issue:2 | Identification of phenylisoxazolines as novel and viable antibacterial agents active against Gram-positive pathogens. |
| AID542711 | fT>MIC in Bacillus anthracis infected in vitro hollow fiber PK/PD model at simulated dose of 500 mg /day administered as 2 divided doses every 12 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID1721015 | Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability measured after 48 hrs by MTT assay | 2020 | Journal of medicinal chemistry, 09-10, Volume: 63, Issue:17 | Discovery of a Conformationally Constrained Oxazolidinone with Improved Safety and Efficacy Profiles for the Treatment of Multidrug-Resistant Tuberculosis. |
| AID562382 | Antimicrobial activity against vancomycin-nonsusceptible Enterococcus faecium clinical isolates assessed as percent susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID1578413 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus NRS123 by broth liquid microdilution method | 2020 | European journal of medicinal chemistry, Jan-01, Volume: 185 | Modifying the lipophilic part of phenylthiazole antibiotics to control their drug-likeness. |
| AID245095 | In vitro minimum inhibitory concentration against Pseudomonas aeruginosa (ATCC 27853) | 2005 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 15, Issue:12 | Synthesis and antibacterial activity of novel (un)substituted benzotriazolyl oxazolidinone derivatives. |
| AID283609 | Antimicrobial activity against Enterococcus faecalis Ho 4450-0446 with heterozygous 23S rRNA G2576U mutation | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | In vitro activity of the oxazolidinone RWJ-416457 against linezolid-resistant and -susceptible staphylococci and enterococci. |
| AID285508 | Antibacterial activity against Streptococcus pneumoniae by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | In vitro and in vivo antibacterial activities of heteroaryl isothiazolones against resistant gram-positive pathogens. |
| AID519087 | Antimicrobial activity against Escherichia coli KM89-94 harboring G2576U mutation in 23S rRNA by agar dilution method in presence of 16 ug/ml polymyxin B nonapeptide | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Linezolid and tiamulin cross-resistance in Staphylococcus aureus mediated by point mutations in the peptidyl transferase center. |
| AID528976 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus isolated from ICU patient urine assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID246859 | Antibacterial activity against Staphylococcus aureus was evaluated in infected mice | 2004 | Bioorganic & medicinal chemistry letters, Aug-02, Volume: 14, Issue:15 | Synthesis and antibacterial activity of arylpiperazinyl oxazolidinones with diversification of the N-substituents. |
| AID285319 | Antimicrobial activity against Nocardis brasiliensis by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Daptomycin susceptibility of unusual gram-positive bacteria: comparison of results obtained by the Etest and the broth microdilution method. |
| AID528701 | Antibacterial activity against Streptococcus viridans clinical isolate assessed as susceptibility level by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID573147 | Antibacterial activity against penicillin-nonsusceptible Streptococcus viridans assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID533983 | Bacteriostatic activity against linezolid-susceptible Staphylococcus aureus ATCC 33591 infected in THP1 cells after 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Cellular pharmacodynamics of the novel biaryloxazolidinone radezolid: studies with infected phagocytic and nonphagocytic cells, using Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Legionella pneumophila. |
| AID1167996 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis clinical isolate 5642 after overnight incubation by two-fold serial dilution method | 2014 | Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21 | Synthesis and biological evaluation of novel peptide BF2 as an antibacterial agent against clinical isolates of vancomycin-resistant enterococci. |
| AID1361101 | Bacteriostatic activity against methicillin-resistant Staphylococcus aureus USA700 NRS386 clinical isolate after 20 hrs by broth microdilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | N-(1,3,4-oxadiazol-2-yl)benzamide analogs, bacteriostatic agents against methicillin- and vancomycin-resistant bacteria. |
| AID630554 | Antibacterial activity against Staphylococcus aureus ATCC 29213 after 16 hrs by agar dilution method | 2011 | Journal of medicinal chemistry, Nov-10, Volume: 54, Issue:21 | Design, synthesis, and structure-activity relationship studies of highly potent novel benzoxazinyl-oxazolidinone antibacterial agents. |
| AID429425 | Antibacterial activity against Haemophilus influenzae ATCC 49247 by agar dilution method | 2009 | European journal of medicinal chemistry, Aug, Volume: 44, Issue:8 | Synthesis and antibacterial activity of novel 5-(4-methyl-1H-1,2,3-triazole) methyl oxazolidinones. |
| AID576418 | Volume of distribution at steady state in two-compartment pharmacokinetic/pharmacodynamic model at 400 mg, bid administered as 0.5 hrs infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID323821 | Reduction in bioluminescent methicillin-sensitive Staphylococcus aureus Xen29 in neutropenic CD1 mouse with peritonitis at 100 mg/kg, po after 3 hrs relative to control | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Rapid bactericidal activity of daptomycin against methicillin-resistant and methicillin-susceptible Staphylococcus aureus peritonitis in mice as measured with bioluminescent bacteria. |
| AID571830 | Antibacterial activity against Ruminococcus gnavus by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID571798 | Antibacterial activity against Clostridium beijerinckii by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID566581 | Antimicrobial activity against Staphylococcus saprophyticus ATCC 15305 by conventional agar-dilution method | 2011 | European journal of medicinal chemistry, Jan, Volume: 46, Issue:1 | Discovery of a novel nitroimidazolyl-oxazolidinone hybrid with potent anti Gram-positive activity: Synthesis and antibacterial evaluation. |
| AID511394 | Antibacterial activity against Streptococcus pyogenes by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Comparative in vitro activities of nemonoxacin (TG-873870), a novel nonfluorinated quinolone, and other quinolones against clinical isolates. |
| AID528719 | Antibacterial activity against vancomycin resistant Enterococcus faecium VanA clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID564834 | Antimicrobial activity against methicillin-susceptible coagulase-negative Staphylococcus hominis assessed as susceptible isolates after 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID576889 | Ratio of Cmax to MIC for 12.5 hrs peripheral compartment culture samples of Enterococcus faecalis ATCC 29212 in two-compartment pharmacokinetic/pharmacodynamic model at 600 mg, bid administered as 0.5 hr infusion for 2 days | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID1692907 | Antibacterial activity against hospital acquired linezolid-resistant Enterococcus faecalis clinical isolates | 2021 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 32 | Design, synthesis and antibacterial evaluation of novel oxazolidinone derivatives nitrogen-containing fused heterocyclic moiety. |
| AID558471 | Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus 555 measured on day 5 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID1852668 | Antibacterial activity against multidrug resistant Pseudomonas aeruginosa BAA 2109 assessed as inhibition of bacterial growth incubated for 24 hrs in MP-MOPS medium by twofold serial dilution method | |||
| AID373750 | Antimicrobial activity against mupirocin-resistant methicillin-resistant Staphylococcus aureus assessed as resistant rate by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Mupirocin-resistant, methicillin-resistant Staphylococcus aureus strains in Canadian hospitals. |
| AID1361108 | Bactericidal activity against methicillin-resistant Staphylococcus aureus USA300 NRS384 clinical isolate preincubated for 20 hrs followed by TSA plating and measured after 18 hrs | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | N-(1,3,4-oxadiazol-2-yl)benzamide analogs, bacteriostatic agents against methicillin- and vancomycin-resistant bacteria. |
| AID292901 | Antimicrobial activity against staphylococcus aureus by broth dilution method | 2007 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 17, Issue:2 | New carbon-linked azole oxazolidinones with improved potency and pharmacokinetics. |
| AID442653 | Antibacterial activity against Streptococcus pyogenes after 24 hrs by spectrophotometry | 2010 | European journal of medicinal chemistry, Feb, Volume: 45, Issue:2 | Synthesis of nitroimidazole derived oxazolidinones as antibacterial agents. |
| AID522889 | Antibacterial activity against vancomycin-intermediate Staphylococcus aureus isolate 1287 after 24 hrs by modified broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Antistaphylococcal activity of ACHN-490 tested alone and in combination with other agents by time-kill assay. |
| AID1852667 | Antibacterial activity against multidrug resistant Klebsiella pneumoniae ATCC13883 assessed as inhibition of bacterial growth incubated for 24 hrs in MHI medium by twofold serial dilution method | |||
| AID285039 | Antimicrobial activity against Corynebacterium spp. by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID348595 | Antibacterial activity against coagulase negative Staphylococcus after 18 to 20 hrs by agar dilution method | 2008 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 18, Issue:21 | Synthesis and antibacterial activities of novel oxazolidinones having cyclic sulfonamide moieties. |
| AID1151727 | Antibacterial activity against Streptococcus agalactiae | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID283620 | Antimicrobial activity against Enterococcus faecium 31 with heterozygous 23S rRNA G2576U mutation | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | In vitro activity of the oxazolidinone RWJ-416457 against linezolid-resistant and -susceptible staphylococci and enterococci. |
| AID373842 | Antimicrobial activity against vancomycin-resistant Staphylococcus aureus 509 Michigan after 18 passages with quinupristin-dalfopristin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID558510 | Antimicrobial activity against heterogeneous vancomycin-intermediate Staphylococcus aureus 873 measured on day 25 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID671562 | Antibacterial activity against Streptococcus pneumoniae SPN160 | 2012 | Journal of medicinal chemistry, Jan-26, Volume: 55, Issue:2 | Fluorocyclines. 2. Optimization of the C-9 side-chain for antibacterial activity and oral efficacy. |
| AID516168 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus clinical isolates assessed as susceptible isolates by EUCAST method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | In vitro activity of telavancin against a contemporary worldwide collection of Staphylococcus aureus isolates. |
| AID1337722 | Antibacterial activity against Enterococcus faecalis ATCC 29212 after 18 to 24 hrs by broth microdilution method | 2016 | European journal of medicinal chemistry, Nov-29, Volume: 124 | New isoxazolidinone and 3,4-dehydro-β-proline derivatives as antibacterial agents and MAO-inhibitors: A complex balance between two activities. |
| AID1616125 | Antimicrobial activity against Streptococcus pneumoniae ATCC 49619 | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Recent advancements in mechanistic studies and structure activity relationship of F |
| AID561342 | Antibacterial activity against Beta-hemolytic Streptococcus group A by CLSI broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Potency and bactericidal activity of iclaprim against recent clinical gram-positive isolates. |
| AID1904086 | Antibacterial activity against Enterobacter cloacae ATCC 13047 | 2022 | European journal of medicinal chemistry, Apr-05, Volume: 233 | Alternative approaches utilizing click chemistry to develop next-generation analogs of solithromycin. |
| AID532784 | Antibacterial activity against vancomycin-susceptible Staphylococcus aureus Mu50 after 24 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Improved antimicrobial activity of linezolid against vancomycin-intermediate Staphylococcus aureus. |
| AID1151730 | Antibacterial activity against Streptococcus constellatus | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID559371 | Antimicrobial activity against compound-intermediate susceptible Coxiella burnetii isolate CP3 obtained from patient with acute Q fever infected in african green monkey Vero cells after 24 hrs by shell vial assay | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Bacteriostatic and bactericidal activities of tigecycline against Coxiella burnetii and comparison with those of six other antibiotics. |
| AID571825 | Antibacterial activity against Coprobacillus cateniformis by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID561239 | Antibacterial activity against methicillin-resistant Staphylococcus aureus assessed as intermediate isolates by CLSI M100-S17 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | AFN-1252, a FabI inhibitor, demonstrates a Staphylococcus-specific spectrum of activity. |
| AID576138 | Antibacterial activity against 10'4 to 10'5 CFU methicillin-resistant coagulase-negative Staphylococcus after 18 hrs by CLSI 2-fold agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | In vitro and in vivo activities of LCB01-0371, a new oxazolidinone. |
| AID1151715 | Antibacterial activity against Staphylococcus haemolyticus | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID285329 | Antimicrobial activity against Streptococcus pyogenes ATCC 19615 | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | In vitro activity of aurein 1.2 alone and in combination with antibiotics against gram-positive nosocomial cocci. |
| AID267721 | Antimicrobial activity against Streptococcus pneumoniae | 2006 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 16, Issue:13 | Synthesis and structure-activity studies of antibacterial oxazolidinones containing dihydrothiopyran or dihydrothiazine C-rings. |
| AID1649284 | Antibacterial activity against Enterococcus faecalis SR1004 assessed as inhibition of bacterial growth incubated for 20 hrs by microdilution broth method | |||
| AID278914 | Antibacterial activity against methicillin-resistant coagulase-negative staphylococci | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | In vitro antibacterial activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. |
| AID555308 | Antibacterial activity against methicillin-resistant coagulase-negative Staphylococcus epidermidis 074 by broth macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Antistaphylococcal activity of dihydrophthalazine antifolates, a family of novel antibacterial drugs. |
| AID285546 | AUC (0-24 hrs) in mouse at 50 mg/kg, sc | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | In vitro and in vivo antibacterial activities of heteroaryl isothiazolones against resistant gram-positive pathogens. |
| AID1744562 | Antibacterial activity against Staphylococcus aureus ATCC 29213 assessed as inhibition of bacterial growth measured after 16 hrs by agar plate dilution method | 2021 | ACS medicinal chemistry letters, Mar-11, Volume: 12, Issue:3 | Semisynthesis and Biological Evaluation of Platencin Thioether Derivatives: Dual FabF and FabH Inhibitors against MRSA. |
| AID511395 | Antibacterial activity against Streptococcus agalactiae by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Comparative in vitro activities of nemonoxacin (TG-873870), a novel nonfluorinated quinolone, and other quinolones against clinical isolates. |
| AID560515 | Antimicrobial activity against SCCmec type III vancomycin-intermediate Staphylococcus aureus isolate 13b16 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID206234 | Minimum inhibitory concentration against Staphylococcus epidermis UC12084 | 1998 | Journal of medicinal chemistry, Sep-10, Volume: 41, Issue:19 | Piperazinyl oxazolidinone antibacterial agents containing a pyridine, diazene, or triazene heteroaromatic ring. |
| AID555507 | Antibacterial activity against methicillin-resistant coagulase-negative Staphylococcus epidermidis 197 after 50 passages by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Antistaphylococcal activity of dihydrophthalazine antifolates, a family of novel antibacterial drugs. |
| AID567488 | Antimicrobial activity against vancomycin pretreated vancomycin-intermediate Staphylococcus aureus isolate 3 obtained from wound of patient by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Clinical outcomes by methicillin-resistant Staphylococcus aureus staphylococcal cassette chromosome mec type: isolates recovered from a phase IV clinical trial of linezolid and vancomycin for complicated skin and skin structure infections. |
| AID573128 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID1603311 | Antimicrobial activity against Acinetobacter baumannii ATCC 19606 measured after 16 hrs by broth microdilution method | 2019 | ACS medicinal chemistry letters, Mar-14, Volume: 10, Issue:3 | Expanded Structure-Activity Studies of Lipoxazolidinone Antibiotics. |
| AID555513 | Antibacterial activity against methicillin-resistant, Linezolid non-susceptible coagulase-negative Staphylococcus epidermidis 345 after 50 passages by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Antistaphylococcal activity of dihydrophthalazine antifolates, a family of novel antibacterial drugs. |
| AID308924 | Antibacterial activity against methicillin-resistant Streptococcus pyogenes ATCC 14289 by broth microdilution method | 2007 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 17, Issue:18 | Synthesis and in vitro antibacterial activity of novel methylamino piperidinyl oxazolidinones. |
| AID523785 | Antimicrobial activity against linezolid-susceptible coagulase-negative Staphylococcus assessed as percent susceptible strain by CLSI method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative activities of TR-700 (torezolid) against staphylococcal blood isolates collected in Spain. |
| AID645040 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus ATCC 25923 after 16 to 20 hrs by microbroth dilution method | 2012 | European journal of medicinal chemistry, Apr, Volume: 50 | Synthesis and preliminary antibacterial evaluation of Linezolid-like 1,2,4-oxadiazole derivatives. |
| AID1778651 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 assessed as inhibition of bacterial growth by broth microdilution method | 2021 | European journal of medicinal chemistry, Oct-05, Volume: 221 | Design, synthesis and evaluation of novel 9-arylalkyl-10-methylacridinium derivatives as highly potent FtsZ-targeting antibacterial agents. |
| AID424759 | Antibacterial activity against macrolide-sensitive, Linezolid, methicillin-resistant Staphylococcus aureus CL5814 after 20 hrs by twofold serial broth dilution method | 2009 | Journal of natural products, May-22, Volume: 72, Issue:5 | Thiazomycins, thiazolyl peptide antibiotics from Amycolatopsis fastidiosa. |
| AID577139 | Apparent volume of distribution in two-compartment pharmacokinetic/pharmacodynamic model at 200 mg, bid administered as 0.5 hr infusion over 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID1594371 | Antibacterial activity against Acinetobacter baumannii BAA1605 after 18 to 24 hrs in presence of colistin by broth microdilution assay | 2019 | Bioorganic & medicinal chemistry, 05-01, Volume: 27, Issue:9 | Second-generation aryl isonitrile compounds targeting multidrug-resistant Staphylococcus aureus. |
| AID245286 | Minimum inhibition concentration against Staphylococcus aureus strains in presence of 2% calf serum | 2005 | Bioorganic & medicinal chemistry letters, Jun-02, Volume: 15, Issue:11 | Biaryl isoxazolinone antibacterial agents. |
| AID1272263 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus ATCC 29213 after 18 to 20 hrs by microdilution method | 2016 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 26, Issue:3 | A stepwise dechlorination/cross-coupling strategy to diversify the vancomycin 'in-chloride'. |
| AID558086 | Antimicrobial activity against Mycoplasma hominis isolated from human by two fold serial dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Comparative in vitro susceptibilities of human mycoplasmas and ureaplasmas to a new investigational ketolide, CEM-101. |
| AID717215 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus CCARM 3635 incubated for 24 hrs by microtiter broth dilution method | 2012 | Journal of natural products, Dec-28, Volume: 75, Issue:12 | Antibacterial butenolides from the Korean tunicate Pseudodistoma antinboja. |
| AID576137 | Antibacterial activity against 10'4 to 10'5 CFU Streptococcus pyogenes after 18 hrs by CLSI 2-fold agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | In vitro and in vivo activities of LCB01-0371, a new oxazolidinone. |
| AID1197123 | Antibacterial activity against Streptococcus oralis ATCC 9811 after 16 to 20 hrs by broth microdilution method | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3 | Structure-activity relationship for the oxadiazole class of antibiotics. |
| AID1435922 | Antibacterial activity against methicillin/ciprofloxacin/gentamicin/clindamycin-resistant Staphylococcus aureus USA200 NRS383 clinical isolate after 18 to 20 hrs by broth microdilution method | 2017 | European journal of medicinal chemistry, Jan-27, Volume: 126 | Phenylthiazole antibiotics: A metabolism-guided approach to overcome short duration of action. |
| AID1770358 | Bactericidal activity against penicillin-resistant Staphylococcus aureus ATCC 31007 assessed as inhibition of bacterial growth measured after 20 hrs by two-fold microdilution assay | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Modification of 5-methylphenanthridium from benzothiazoles to indoles as potent FtsZ inhibitors: Broadening the antibacterial spectrum toward vancomycin-resistant enterococci. |
| AID519486 | Antibacterial activity against Staphylococcus aureus T1888 expressing 23S rrn 3 G2576T and rrn 5 G2576T mutants by Etest method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Linezolid resistance in Staphylococcus aureus: gene dosage effect, stability, fitness costs, and cross-resistances. |
| AID558505 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus 540 measured on day 20 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID763950 | Antibacterial activity against Moraxella catarrhalis clinical isolate 255 after 18 hrs by NCCLS agar dilution method | 2013 | European journal of medicinal chemistry, Aug, Volume: 66 | Synthesis and antibacterial activities of N-substituted-glycinyl 1H-1,2,3-triazolyl oxazolidinones. |
| AID535036 | Antimicrobial activity against vancomycin intermediate Staphylococcus aureus NRS-403 expressing SCCmec type 2 element by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | In vitro activity of ceftaroline against community-associated methicillin-resistant, vancomycin-intermediate, vancomycin-resistant, and daptomycin-nonsusceptible Staphylococcus aureus isolates. |
| AID1547704 | Antibacterial activity against Staphylococcus aureus ATCC 27660 by broth microdilution method | 2020 | ACS medicinal chemistry letters, Mar-12, Volume: 11, Issue:3 | Structure-Activity Relationship for the Oxadiazole Class of Antibacterials. |
| AID292614 | Antimicrobial activity against Haemophilus influenzae ATCC 49247 by agar dilution method | 2007 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 17, Issue:17 | Synthesis and antibacterial activity of novel oxazolidinones with methylene oxygen- and methylene sulfur-linked substituents at C5-position. |
| AID1519052 | Stability in human liver microsomes assessed as compound remaining at 1.5 uM preincubated for 5 mins with NADPH and measured after 45 mins by LC/MS analysis | 2020 | European journal of medicinal chemistry, Jan-01, Volume: 185 | Optimization of biaryloxazolidinone as promising antibacterial agents against antibiotic-susceptible and antibiotic-resistant gram-positive bacteria. |
| AID532809 | Antibacterial activity against vancomycin-susceptible Staphylococcus aureus BR3 after 24 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Improved antimicrobial activity of linezolid against vancomycin-intermediate Staphylococcus aureus. |
| AID697275 | Antibacterial activity against vancomycin-resistant Staphylococcus aureus ARC 3186 after 18 to 24 hrs by CLSI broth microdilution method | 2012 | Journal of medicinal chemistry, Aug-09, Volume: 55, Issue:15 | Novel N-linked aminopiperidine inhibitors of bacterial topoisomerase type II with reduced pK(a): antibacterial agents with an improved safety profile. |
| AID1407931 | Antibacterial activity against Staphylococcus aureus ATCC 29213 after 24 hrs in presence of 2% human albumin by broth microdilution method | 2018 | European journal of medicinal chemistry, Sep-05, Volume: 157 | Discovery of dual GyrB/ParE inhibitors active against Gram-negative bacteria. |
| AID383567 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 700699 by broth microdilution technique | 2008 | European journal of medicinal chemistry, Apr, Volume: 43, Issue:4 | Synthesis and in vitro antibacterial activities of novel oxazolidinones. |
| AID520484 | Toxicity in methicillin-resistant Staphylococcus aureus-infected New Zealand rabbit osteomyelitis model assessed as body weight at 30 mg/kg, sc administered every 12 hrs for 4 days measured on week 2 postinfection (Rvb = 2.84 +/- 0.30 kg) | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Efficacies of ceftobiprole medocaril and comparators in a rabbit model of osteomyelitis due to methicillin-resistant Staphylococcus aureus. |
| AID533409 | Antimicrobial activity against Finegoldia magna by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activities of doripenem, a new broad-spectrum carbapenem, against recently collected clinical anaerobic isolates, with emphasis on the Bacteroides fragilis group. |
| AID278857 | Inhibition of metabolic activity in primary human osteoblasts assessed as MTT reduction after 48 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Influence on mitochondria and cytotoxicity of different antibiotics administered in high concentrations on primary human osteoblasts and cell lines. |
| AID520512 | Cmin in New Zealand rabbit osteomyelitis model at 40 mg/kg, sc administered every 6 hrs for 4 days | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Efficacies of ceftobiprole medocaril and comparators in a rabbit model of osteomyelitis due to methicillin-resistant Staphylococcus aureus. |
| AID633447 | Bacteriostatic activity against Staphylococcus aureus ATCC 01001 infected in thigh of CD1 mouse assessed as prevention of colony formation at 80 mg/kg, po administered 2 hrs post infection measured after 12 hrs | 2011 | Journal of medicinal chemistry, Dec-08, Volume: 54, Issue:23 | Antibacterial optimization of 4-aminothiazolyl analogues of the natural product GE2270 A: identification of the cycloalkylcarboxylic acids. |
| AID524693 | Antibacterial activity against Corynebacterium sp. by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro antibacterial activity of CE-156811, a novel analog derived from hygromycin A. |
| AID571817 | Antibacterial activity against Bifidobacterium bifidum by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID1407937 | Antifungal activity against Candida albicans ATCC 90028 after 24 hrs by broth microdilution method | 2018 | European journal of medicinal chemistry, Sep-05, Volume: 157 | Discovery of dual GyrB/ParE inhibitors active against Gram-negative bacteria. |
| AID1493808 | Antibacterial activity against vancomycin-resistant Enterococcus faecium ATCC 700221 after 20 hrs by broth microdilution method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Biphenylthiazole antibiotics with an oxadiazole linker: An approach to improve physicochemical properties and oral bioavailability. |
| AID405617 | Antibacterial activity against Staphylococcus aureus | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Comparative study of the effects of pyridoxine, rifampin, and renal function on hematological adverse events induced by linezolid. |
| AID68065 | Antibacterial activity against ciprofloxacin resistant Enterococcus faecium (EF4016 CipR) | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | Novel oxazolidinone-quinolone hybrid antimicrobials. |
| AID577115 | ABBC (0 to 24 hrs) in Enterococcus faecalis Ef1497 in two-compartment pharmacokinetic/pharmacodynamic model at 800 mg, bid administered as 0.5 hr infusion for 2 days | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID94375 | In vitro antibacterial activity against Klebsiella pneumoniae strain UC 12081 | 1996 | Journal of medicinal chemistry, Feb-02, Volume: 39, Issue:3 | Synthesis and antibacterial activity of U-100592 and U-100766, two oxazolidinone antibacterial agents for the potential treatment of multidrug-resistant gram-positive bacterial infections. |
| AID319165 | Nonrenal clearance in human | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7 | Linezolid (ZYVOX), the first member of a completely new class of antibacterial agents for treatment of serious gram-positive infections. |
| AID1501358 | Antibacterial activity against methicillin-resistant Staphylococcus aureus USA100 NRS382 after 20 hrs by broth microdilution assay | 2017 | European journal of medicinal chemistry, Oct-20, Volume: 139 | Arylthiazole antibiotics targeting intracellular methicillin-resistant Staphylococcus aureus (MRSA) that interfere with bacterial cell wall synthesis. |
| AID207796 | Compound was evaluated for minimum inhibitory concentration against Staphylococcus aureus 975 strain | 2002 | Bioorganic & medicinal chemistry letters, Mar-25, Volume: 12, Issue:6 | Synthesis and antibacterial activity of linezolid analogues. |
| AID763986 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus after 18 hrs by NCCLS agar dilution method | 2013 | European journal of medicinal chemistry, Aug, Volume: 66 | Synthesis and antibacterial activities of N-substituted-glycinyl 1H-1,2,3-triazolyl oxazolidinones. |
| AID1079946 | Presence of at least one case with successful reintroduction. [column 'REINT' in source] | |||
| AID1692402 | Antibacterial activity against methicillin and linezolid resistant Staphylococcus aureus NRS119 assessed as reduction in bacterial growth incubated for 18 to 24 hrs by broth microdilution method | 2020 | European journal of medicinal chemistry, Aug-15, Volume: 200 | Pharmacomodulations of the benzoyl-thiosemicarbazide scaffold reveal antimicrobial agents targeting d-alanyl-d-alanine ligase in bacterio. |
| AID1877890 | Antibacterial activity against wild type Escherichia coli DSM-11116 assessed as bacterial growth inhibition | 2022 | Bioorganic & medicinal chemistry letters, 03-01, Volume: 59 | Novel 2,4-disubstituted quinazoline analogs as antibacterial agents with improved cytotoxicity profile: Modification of the benzenoid part. |
| AID559283 | Antimicrobial activity against Enterococcus faecalis JH2-2 harboring nucleotides at position 2576 in rrlA 2576T, rrlB 2576G, rrlC 2576T and rrlD 2576T after 9, 10, 11 passages under Linezolid selective pressure by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Influence of recombination on development of mutational resistance to linezolid in Enterococcus faecalis JH2-2. |
| AID1400758 | Bactericidal activity against methicillin-resistant Staphylococcus aureus isolate 2 after 24 hrs by calgary biofilm device-based assay | 2017 | MedChemComm, Apr-01, Volume: 8, Issue:4 | Microwave-enhanced Friedländer synthesis for the rapid assembly of halogenated quinolines with antibacterial and biofilm eradication activities against drug resistant and tolerant bacteria. |
| AID1680002 | Resistance ratio of compound MIC for methicillin-resistant Staphylococcus aureus after 20 passages to compound MIC for methicillin-resistant Staphylococcus aureus after 16 to 20 hrs by CLSI-based broth microdilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Synthesis and antibacterial bioactivities of cationic deacetyl linezolid amphiphiles. |
| AID1303406 | Antibacterial activity against Escherichia coli after 24 hrs by microdilution method | 2016 | Bioorganic & medicinal chemistry letters, 07-01, Volume: 26, Issue:13 | Identification of novel aminopiperidine derivatives for antibacterial activity against Gram-positive bacteria. |
| AID519489 | Antibacterial activity against Staphylococcus aureus T2019 expressing 23S rrn1 G2576T, rrn2 G2576T, rrn3 G2576T, rrn4 G2576T and rrn5 G2576T mutants by Etest method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Linezolid resistance in Staphylococcus aureus: gene dosage effect, stability, fitness costs, and cross-resistances. |
| AID559281 | Antimicrobial activity against Enterococcus faecalis JH2-2 harboring nucleotides at position 2576 in rrlA 2576T, rrlB 2576G, rrlC 2576G and rrlD 2576T after 5 passages under Linezolid selective pressure by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Influence of recombination on development of mutational resistance to linezolid in Enterococcus faecalis JH2-2. |
| AID525148 | Antimicrobial activity against Staphylococcus epidermidis isolate 426-3147L expressing cfr gene by disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | First report of cfr-mediated resistance to linezolid in human staphylococcal clinical isolates recovered in the United States. |
| AID1680063 | Antibacterial activity against methicillin-resistant Staphylococcus aureus clinical isolate 3 assessed as reduction in bacterial growth incubated for 16 to 20 hrs by CLSI-based broth microdilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Synthesis and antibacterial bioactivities of cationic deacetyl linezolid amphiphiles. |
| AID560507 | Antimicrobial activity against SCCmec type III vancomycin-intermediate Staphylococcus aureus isolate b2k3421 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID424769 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae CL5771 after 20 hrs by twofold serial broth dilution method | 2009 | Journal of natural products, May-22, Volume: 72, Issue:5 | Thiazomycins, thiazolyl peptide antibiotics from Amycolatopsis fastidiosa. |
| AID531556 | Antibacterial activity against coagulase-negative Staphylococcus lugdunensis obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID1649295 | Antibacterial activity against Klebsiella pneumoniae SR1 assessed as inhibition of bacterial growth incubated for 20 hrs by microdilution broth method | |||
| AID275461 | Antibacterial activity against vancomycin-sensitive Staphylococcus aureus F988633 | 2007 | Journal of medicinal chemistry, Jan-25, Volume: 50, Issue:2 | Isothiazoloquinolones with enhanced antistaphylococcal activities against multidrug-resistant strains: effects of structural modifications at the 6-, 7-, and 8-positions. |
| AID531554 | Antibacterial activity against coagulase-negative Staphylococcus epidermidis obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID1241208 | Inhibition of pre-miR-21 (unknown origin) cleavage assessed as reduction of oncogenic microRNAs biogenesis by measuring fluorescence every minute for 5 hrs using 5'-FAM,3'-dabcyl-pre-miRNA beacons by FRET assay in presence of recombinant Dicer | 2015 | Bioorganic & medicinal chemistry, Sep-01, Volume: 23, Issue:17 | Ribosome-targeting antibiotics as inhibitors of oncogenic microRNAs biogenesis: Old scaffolds for new perspectives in RNA targeting. |
| AID532813 | Antibacterial activity against vancomycin-intermediate Staphylococcus aureus MI phenotypic revertant after 24 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Improved antimicrobial activity of linezolid against vancomycin-intermediate Staphylococcus aureus. |
| AID283177 | Increase in biofilm formation of Staphylococcus epidermidis RP62A at 0.25 times MIC | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | In vitro effects of antimicrobial agents on planktonic and biofilm forms of Staphylococcus lugdunensis clinical isolates. |
| AID562381 | Antimicrobial activity against Enterococcus faecium expressing VanA gene clinical isolates assessed as percent susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID590151 | Antibacterial activity against methicillin-resistant Staphylococcus aureus Smith infected po dosed ICR mouse assessed as protection against mouse mortality administered 1 hr after infection measured up to 7 days | 2011 | European journal of medicinal chemistry, Apr, Volume: 46, Issue:4 | Discovery of torezolid as a novel 5-hydroxymethyl-oxazolidinone antibacterial agent. |
| AID1861518 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus Sta-001 incubated for 18 hrs by CLSI protocol based two-fold serial agar dilution method | 2022 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 71 | WCK 4034: A promising oxazolidinone for treating gram positive infections. |
| AID571996 | Antibacterial activity against Peptostreptococcus anaerobius by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID278927 | Antibacterial activity against Legionella pneumophila | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | In vitro antibacterial activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. |
| AID1862426 | Antibacterial activity against methicillin-resistant Staphylococcus aureus USA 300 (ARLG 1568) assessed as reduction in visible bacterial growth incubated for 18 to 20 hrs by CLSI based broth microdilution analysis | 2022 | European journal of medicinal chemistry, Oct-05, Volume: 240 | Membrane acting Povarov-Doebner derived compounds potently disperse preformed multidrug resistant Gram-positive bacterial biofilms. |
| AID524983 | Antibacterial activity against Streptococcus sp. clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Comparative surveillance study of telavancin activity against recently collected gram-positive clinical isolates from across the United States. |
| AID1852691 | Antibacterial activity against Escherichia coli SQ110 DTC G2032A incubated for 24 hrs by twofold serial dilution method | |||
| AID206224 | In vitro antibacterial activity against methicillin resistant Staphylococcus epidermis US 12084 (MRSE) | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | The effect of remote chirality on the antibacterial activity of indolinyl, tetrahydroquinolyl and dihydrobenzoxazinyl oxazolidinones. |
| AID410105 | Antimicrobial activity against erm (B) expressing Streptococcus pyogenes Msr 610 by NCCLS method | 2008 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 18, Issue:23 | Design at the atomic level: design of biaryloxazolidinones as potent orally active antibiotics. |
| AID523803 | Antimicrobial activity against linezolid-susceptible Staphylococcus aureus assessed as inhibition of microbial growth at 4 ug/ml by CLSI method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative activities of TR-700 (torezolid) against staphylococcal blood isolates collected in Spain. |
| AID1139114 | Antimicrobial activity against Streptococcus pneumoniae infected in rat lung infection model assessed as log reduction of bacterial density at 3 mg/kg, po | 2014 | Bioorganic & medicinal chemistry letters, May-01, Volume: 24, Issue:9 | Successful application of serum shift prediction models to the design of dual targeting inhibitors of bacterial gyrase B and topoisomerase IV with improved in vivo efficacy. |
| AID577111 | ABBC (0 to 24 hrs) in Staphylococcus aureus RN4220 MutS2 in two-compartment pharmacokinetic/pharmacodynamic model at 600 mg, bid administered as 0.5 hr infusion for 2 days | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID1703726 | Antibacterial activity against vancomycin-resistant Enterococcus faecium ATCC 700221 assessed as inhibition of bacterial growth measured after 18 to 20 hrs by CLSI protocol based broth microdilution method | 2020 | European journal of medicinal chemistry, Sep-15, Volume: 202 | Evaluation of N-phenyl-2-aminothiazoles for treatment of multi-drug resistant and intracellular Staphylococcus aureus infections. |
| AID1721061 | Antitubercular activity against Mycobacterium tuberculosis H37Rv infected in Balb/c mouse assessed as reduction in lung bacterial burden at 50 to 100 mg/kg/day, po administered via gavage 5 times per week for 3 weeks starting from 10 days post-infection a | 2020 | Journal of medicinal chemistry, 09-10, Volume: 63, Issue:17 | Discovery of a Conformationally Constrained Oxazolidinone with Improved Safety and Efficacy Profiles for the Treatment of Multidrug-Resistant Tuberculosis. |
| AID523809 | Antimicrobial activity against linezolid-susceptible coagulase-negative Staphylococcus assessed as inhibition of microbial growth at =< 0.25 ug/ml by CLSI method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative activities of TR-700 (torezolid) against staphylococcal blood isolates collected in Spain. |
| AID726196 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae C402 by agar dilution method | 2013 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 23, Issue:5 | Synthesis and antibacterial activities of new piperidine substituted (5R)-[1,2,3]triazolylmethyl and (5R)-[(4-F-[1,2,3]triazolyl)methyl] oxazolidinones. |
| AID1421233 | Antibacterial activity against linezolid-resistant Enterococcus faecalis clinical isolates by broth liquid microdilution method | 2018 | European journal of medicinal chemistry, Oct-05, Volume: 158 | Synthesis and antibacterial activity evaluation of novel biaryloxazolidinone analogues containing a hydrazone moiety as promising antibacterial agents. |
| AID284954 | Antimicrobial activity against Bacillus cereus at 0.5 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID1611120 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus CLSI-based double dilution method | 2019 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 29, Issue:23 | Design and synthesis of biaryloxazolidinone derivatives containing amide or acrylamide moiety as novel antibacterial agents against Gram-positive bacteria. |
| AID319149 | Oral bioavailability in rat at 25 mg/kg | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7 | Linezolid (ZYVOX), the first member of a completely new class of antibacterial agents for treatment of serious gram-positive infections. |
| AID1117377 | Antimicrobial activity against Staphylococcus aureus Efs4 assessed as inhibition zone at 37 degC for 24 hrs by agar diffusion method | 2010 | MedChemComm, Aug-01, Volume: 1, Issue:2 | Syntheses and biological evaluation of new cephalosporin-oxazolidinone conjugates. |
| AID370012 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus Smith infected in C3H mouse assessed as reduction in log number of CFU at 12.5 mg/kg/day, po administered within 15 mins of infection measured after 48 hrs by organ burden assay | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vivo efficacy of a novel oxazolidinone compound in two mouse models of infection. |
| AID583883 | Antibacterial activity against laboratory-generated cfr-transformed Staphylococcus aureus by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Elevated linezolid resistance in clinical cfr-positive Staphylococcus aureus isolates is associated with co-occurring mutations in ribosomal protein L3. |
| AID1126487 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus | 2014 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 24, Issue:8 | Synthesis, antibiotic activity and structure-activity relationship study of some 3-enaminetetramic acids. |
| AID1400030 | Inhibition of protein translation/transcription in Escherichia coli S30 cell extract using circular DNA with pBESTluc after 60 mins by luciferase reporter gene assay | 2018 | Bioorganic & medicinal chemistry, 09-15, Volume: 26, Issue:17 | An antimycobacterial pleuromutilin analogue effective against dormant bacilli. |
| AID576898 | Ratio of AUC (0 to 24 hrs) to MIC for Staphylococcus aureus RN4220 in two-compartment pharmacokinetic/pharmacodynamic model at 600 mg, bid administered as 0.5 hr infusion for 2 days | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID1853458 | Bactericidal activity against methicillin-resistant Staphylococcus aureus USA300 assessed as reduction in colony forming unit incubated for 20 hrs | 2021 | RSC medicinal chemistry, Nov-17, Volume: 12, Issue:11 | SF |
| AID528696 | Antibacterial activity against methicillin resistant Staphylococcus aureus MED 2028 osteomyelitis isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID531644 | Displacement of [3H]chloramphenicol from 70S ribosomal complex in Staphylococcus aureus ATCC 29213 by competitive binding assay | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | R chi-01, a new family of oxazolidinones that overcome ribosome-based linezolid resistance. |
| AID1400044 | Antibacterial activity against Staphylococcus aureus BAA 44 incubated for 24 hrs under aerobic condition by MABA | 2018 | Bioorganic & medicinal chemistry, 09-15, Volume: 26, Issue:17 | An antimycobacterial pleuromutilin analogue effective against dormant bacilli. |
| AID541522 | Antimicrobial activity against methicillin-resistant Staphylococcus epidermidis clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID1327100 | Antibacterial activity against Bacillus subtilis NCIM 2010 measured after 12 hrs by spectrophotometric method | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Design, synthesis and biological evaluation of novel azaspiro analogs of linezolid as antibacterial and antitubercular agents. |
| AID103859 | Inhibitory activity against Moraxella catarrhalis UC30610 | 2000 | Journal of medicinal chemistry, Mar-09, Volume: 43, Issue:5 | Substituent effects on the antibacterial activity of nitrogen-carbon-linked (azolylphenyl)oxazolidinones with expanded activity against the fastidious gram-negative organisms Haemophilus influenzae and Moraxella catarrhalis. |
| AID577090 | Ratio of AUC (0 to 24 hrs) to MIC for Enterococcus faecalis Ef1497 in two-compartment pharmacokinetic/pharmacodynamic model at 600 mg, bid administered as 0.5 hr infusion for 2 days | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID1056339 | Inhibition of human CYP1A2 assessed as ethoxyresorufin O-deethylation after 20 mins by fluorescence plate reader | 2013 | ACS medicinal chemistry letters, Nov-14, Volume: 4, Issue:11 | Potent oxazolidinone antibacterials with heteroaromatic C-ring substructure. |
| AID287267 | Antimicrobial activity against Escherichia coli ATCC 25922 | 2007 | European journal of medicinal chemistry, Feb, Volume: 42, Issue:2 | Structure-antibacterial activity of arylcarbonyl- and arylsulfonyl-piperazine 5-triazolylmethyl oxazolidinones. |
| AID285090 | Antimicrobial activity against viridans group Streptococcus gordonii at 0.12 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID1151759 | Antibacterial activity against Streptococcus pyogenes isolate 556 | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID520733 | Antimicrobial activity against Staphylococcus aureus RN4220 harboring plasmid MS2 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Transcriptional and translational control of the mlr operon, which confers resistance to seven classes of protein synthesis inhibitors. |
| AID1519273 | Antibacterial activity agianst Staphylococcus aureus ATCC 29213 | 2019 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 29, Issue:23 | Synthesis and antibacterial evaluation of novel oxazolidinone derivatives containing a piperidinyl moiety. |
| AID410224 | Antibacterial activity against Haemophilus influenzae by broth micro dilution method | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24 | A facile synthesis, antibacterial, and antitubercular studies of some piperidin-4-one and tetrahydropyridine derivatives. |
| AID535019 | Antimicrobial activity against vancomycin intermediate Staphylococcus aureus NRS-4 expressing SCCmec type 2 element by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | In vitro activity of ceftaroline against community-associated methicillin-resistant, vancomycin-intermediate, vancomycin-resistant, and daptomycin-nonsusceptible Staphylococcus aureus isolates. |
| AID1451776 | Antibacterial activity against Staphylococcus aureus NRS271 infected in BALB/c mouse assessed as reduction of bacterial burden in liver at 0.4 mg, ip bid for 4.5 days treated 24 hrs prior to bacterial infection measured 108 hrs post infection relative to | 2017 | Journal of medicinal chemistry, 10-12, Volume: 60, Issue:19 | Novel Inhibitors of Staphyloxanthin Virulence Factor in Comparison with Linezolid and Vancomycin versus Methicillin-Resistant, Linezolid-Resistant, and Vancomycin-Intermediate Staphylococcus aureus Infections in Vivo. |
| AID245296 | In vitro minimum inhibitory concentration of compound against Methicillin-sensitive Staphylococcus aureus ATCC 29213 | 2005 | Bioorganic & medicinal chemistry letters, Jan-17, Volume: 15, Issue:2 | Effects of positional and geometrical isomerism on the biological activity of some novel oxazolidinones. |
| AID542709 | fAUC (24 hrs) in Bacillus anthracis infected in vitro hollow fiber PK/PD model at simulated dose of 800 mg /day administered once every 24 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID1721018 | Stability in CD-1 mouse liver microsome at 1 uM measured after 30 mins in absence of NADPH by LC-MS/MS analysis | 2020 | Journal of medicinal chemistry, 09-10, Volume: 63, Issue:17 | Discovery of a Conformationally Constrained Oxazolidinone with Improved Safety and Efficacy Profiles for the Treatment of Multidrug-Resistant Tuberculosis. |
| AID1174904 | Antibacterial activity against methicillin-resistant Staphylococcus aureus MRSA M923 by broth microdilution method | 2014 | Bioorganic & medicinal chemistry, Dec-15, Volume: 22, Issue:24 | New potent antibacterials against Gram-positive multiresistant pathogens: effects of side chain modification and chirality in linezolid-like 1,2,4-oxadiazoles. |
| AID285117 | Antimicrobial activity against viridans group Streptococcus oralis at 2 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID562385 | Antimicrobial activity against Enterococcus faecalis expressing VanB gene clinical isolates assessed as percent susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID541038 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 infected in Albino guiena pig assessed as no. of culture-negative cage fluid samples at 75 mg/kg measured on day 4 postinfection | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Linezolid alone or combined with rifampin against methicillin-resistant Staphylococcus aureus in experimental foreign-body infection. |
| AID577106 | AUBC (0 to 24 hrs) in Enterococcus faecalis Ef1497 in two-compartment pharmacokinetic/pharmacodynamic model at 600 mg, bid administered as 0.5 hr infusion for 2 days | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID284984 | Antimicrobial activity against Enterococcus avium at 1 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID1151725 | Bactericidal activity against penicillin-resistant Streptococcus pneumoniae | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID552829 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus | 2011 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1 | The discovery and structure-activity relationships leading to CE-156811, a difluorophenyl cyclopropyl fluoroether: a novel potent antibacterial analog derived from hygromycin A. |
| AID581038 | Induction of bacterial membrane damage in Staphylococcus aureus ATCC 25923 at 4 ug/mL by BacLight assay | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Mode of action of Ranbezolid against staphylococci and structural modeling studies of its interaction with ribosomes. |
| AID533965 | Bacteriostatic activity against Listeria monocytogenes EGD infected in THP1 cells after 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Cellular pharmacodynamics of the novel biaryloxazolidinone radezolid: studies with infected phagocytic and nonphagocytic cells, using Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Legionella pneumophila. |
| AID1778663 | Bactericidal activity against penicillin-resistant Staphylococcus epidermidis measured after 24 hrs by CLSI protocol based method | 2021 | European journal of medicinal chemistry, Oct-05, Volume: 221 | Design, synthesis and evaluation of novel 9-arylalkyl-10-methylacridinium derivatives as highly potent FtsZ-targeting antibacterial agents. |
| AID532806 | Antibacterial activity against vancomycin-susceptible Staphylococcus aureus 28160 after 24 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Improved antimicrobial activity of linezolid against vancomycin-intermediate Staphylococcus aureus. |
| AID1233142 | Antibacterial activity against methicillin-resistant Staphylococcus aureus after 18 to 20 hrs by microbroth dilution method | 2015 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 25, Issue:13 | Thiol activated prodrugs of sulfur dioxide (SO2) as MRSA inhibitors. |
| AID424421 | Antibacterial activity against Enterococcus faecalis HIP14333 isolated from patients rectum by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Vancomycin-resistant Staphylococcus aureus isolates associated with Inc18-like vanA plasmids in Michigan. |
| AID523779 | Antimicrobial activity against oxacillin-susceptible Staphylococcus aureus assessed as percent susceptible strain by CLSI method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative activities of TR-700 (torezolid) against staphylococcal blood isolates collected in Spain. |
| AID245238 | In vitro minimum inhibitory concentration against Enterococcus faecalis (ATCC 29212 and 21777) | 2005 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 15, Issue:12 | Synthesis and antibacterial activity of novel (un)substituted benzotriazolyl oxazolidinone derivatives. |
| AID349307 | Antibacterial activity against methicillin-resistant coagulase-negative Staphylococcus clinical isolate after 18 hrs by agar dilution method | 2008 | European journal of medicinal chemistry, May, Volume: 43, Issue:5 | Synthesis and structure-antibacterial activity of triazolyl oxazolidinones containing long chain acyl moiety. |
| AID542906 | Antimicrobial activity against Bacillus anthracis infected in in vitro hollow fiber PK/PD model assessed as bacterial regrowth at 500 mg administered once every 24 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID1539457 | Antibacterial activity against methicillin-resistant Streptococcus pneumoniae ATCC 700677 clinical isolates after 18 to 20 hrs by CLSI-based broth microdilution assay | |||
| AID285051 | Antimicrobial activity against Micrococcus luteus by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID304003 | Toxicity in Sprague-Dawley rat at 1000 mg/kg/day, po after 14 days | 2007 | Journal of medicinal chemistry, Nov-29, Volume: 50, Issue:24 | Antibacterial oxazolidinones possessing a novel C-5 side chain. (5R)-trans-3-[3-Fluoro-4- (1-oxotetrahydrothiopyran-4-yl)phenyl]-2- oxooxazolidine-5-carboxylic acid amide (PF-00422602), a new lead compound. |
| AID373319 | Antibacterial activity against Haemophilus influenzae ATCC 49247 after 18 hrs by NCCLS M7-A4 method | 2009 | European journal of medicinal chemistry, Mar, Volume: 44, Issue:3 | Synthesis, antibacterial and anticonvulsant evaluations of some cyclic enaminones. |
| AID1862420 | Antibacterial activity against Listeria monocytogenes ATCC 19115 assessed as reduction in visible bacterial growth incubated for 18 to 20 hrs by CLSI based broth microdilution analysis | 2022 | European journal of medicinal chemistry, Oct-05, Volume: 240 | Membrane acting Povarov-Doebner derived compounds potently disperse preformed multidrug resistant Gram-positive bacterial biofilms. |
| AID581666 | Antibacterial activity against Staphylococcus aureus SCV isolated from cystic fibrosis patient in cation-adjusted MH 2 broth assessed as log reduction of extracellular CFU level after 24 hrs | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Intracellular activity of antibiotics in a model of human THP-1 macrophages infected by a Staphylococcus aureus small-colony variant strain isolated from a cystic fibrosis patient: pharmacodynamic evaluation and comparison with isogenic normal-phenotype a |
| AID541081 | Cmax in cage fluid of Albino guiena pig at 50 mg/kg, ip after 3 hrs | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Linezolid alone or combined with rifampin against methicillin-resistant Staphylococcus aureus in experimental foreign-body infection. |
| AID558484 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus 547 measured on day 10 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID520007 | Antimicrobial activity against Chlamydophila pneumoniae isolated from human respiratory tract by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID576640 | Bactericidal activity against 1 hr peripheral compartment culture samples of Staphylococcus aureus RN4220 MutS2 in two-compartment pharmacokinetic/pharmacodynamic model assessed as effect on bacterial count at 600 mg, bid administered as 0.5 hr infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID565012 | Antimicrobial activity against methicillin-susceptible coagulase-negative Staphylococcus simulans after 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID561261 | Antibacterial activity against Enterococcus faecalis by CLSI M100-S17 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | AFN-1252, a FabI inhibitor, demonstrates a Staphylococcus-specific spectrum of activity. |
| AID1474217 | Bacteriostatic activity against vancomycin-resistant Enterococcus faecium ATCC 700221 assessed as reduction in CFU at 4 times MIC after 24 hrs | 2017 | Journal of medicinal chemistry, 03-23, Volume: 60, Issue:6 | Phenylthiazole Antibacterial Agents Targeting Cell Wall Synthesis Exhibit Potent Activity in Vitro and in Vivo against Vancomycin-Resistant Enterococci. |
| AID560371 | Antimicrobial activity against vancomycin-resistant Enterococcus faecalis 1058946 by broth dilution method in presence of 4% HSA | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Impact of human serum albumin on oritavancin in vitro activity against enterococci. |
| AID1853452 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 33592 assessed as bacterial growth inhibition incubated for 18 to 20 hrs by CLSI based broth microdilution assay | 2021 | RSC medicinal chemistry, Nov-17, Volume: 12, Issue:11 | SF |
| AID1390471 | Antibacterial activity against Staphylococcus epidermidis ATCC 12228 | 2018 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 28, Issue:7 | Design, synthesis and biological evaluation of spiropyrimidinetriones oxazolidinone derivatives as antibacterial agents. |
| AID278921 | Antibacterial activity against Streptococcus pneumoniae | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | In vitro antibacterial activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. |
| AID528692 | Antibacterial activity against Streptococcus agalactiae MED 2038 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID1311360 | Antibacterial activity against Acinetobacter baumannii ACBA measured after 18 hrs by broth microdilution assay | 2016 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15 | An evolved oxazolidinone with selective potency against Mycobacterium tuberculosis and gram positive bacteria. |
| AID285120 | Antimicrobial activity against viridans group Streptococcus parasanguis at 0.12 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID572022 | Antibacterial activity against Prevotella oris by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID207510 | Minimum inhibitory concentration against Staphylococcus aureus UC6685 | 1998 | Journal of medicinal chemistry, Sep-10, Volume: 41, Issue:19 | Piperazinyl oxazolidinone antibacterial agents containing a pyridine, diazene, or triazene heteroaromatic ring. |
| AID591664 | Antimicrobial activity against multidrug-resistant Haemophilus influenzae after 18 hrs by agar dilution method | 2011 | Journal of medicinal chemistry, Apr-14, Volume: 54, Issue:7 | A new DNA gyrase inhibitor subclass of the cyclothialidine family based on a bicyclic dilactam-lactone scaffold. Synthesis and antibacterial properties. |
| AID524986 | Antibacterial activity against penicillin resistant Streptococcus pneumoniae clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Comparative surveillance study of telavancin activity against recently collected gram-positive clinical isolates from across the United States. |
| AID262231 | Antibacterial activity against Staphylococcus aureus ATCC 14154 | 2006 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 16, Issue:6 | Novel 4-N-substituted aryl pent-2-ene-1,4-dione derivatives of piperazinyloxazolidinones as antibacterials. |
| AID370028 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus Smith infected in iv dosed C3H mouse localized infection model assessed as reduction of number of CFU per gram of kidney administered 15 mins after infection measured after 48 hr | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vivo efficacy of a novel oxazolidinone compound in two mouse models of infection. |
| AID535024 | Antimicrobial activity against vancomycin intermediate Staphylococcus aureus NRS-23 expressing SCCmec type 2 element by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | In vitro activity of ceftaroline against community-associated methicillin-resistant, vancomycin-intermediate, vancomycin-resistant, and daptomycin-nonsusceptible Staphylococcus aureus isolates. |
| AID534793 | Bactericidal activity against community-acquired methicillin-resistant Staphylococcus aureus assessed as antibiotic concentration that reduced the number of viable cells by =>99.9% by colony count method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | In vitro activity of ceftaroline against community-associated methicillin-resistant, vancomycin-intermediate, vancomycin-resistant, and daptomycin-nonsusceptible Staphylococcus aureus isolates. |
| AID1861536 | Volume of distribution in Beagle dog at 15 mg/kg, iv | 2022 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 71 | WCK 4034: A promising oxazolidinone for treating gram positive infections. |
| AID345135 | Antimicrobial activity against Streptococcus pneumoniae 02J1175 expressing mef(A) gene by NCCLS method | 2008 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 18, Issue:23 | Design at the atomic level: generation of novel hybrid biaryloxazolidinones as promising new antibiotics. |
| AID285151 | Antimicrobial activity against viridans group Streptococcus parasanguis by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID201444 | Inhibitory activity against Methicillin-resistant Staphylococcus epidermidis UC12084 | 2000 | Journal of medicinal chemistry, Mar-09, Volume: 43, Issue:5 | Substituent effects on the antibacterial activity of nitrogen-carbon-linked (azolylphenyl)oxazolidinones with expanded activity against the fastidious gram-negative organisms Haemophilus influenzae and Moraxella catarrhalis. |
| AID559280 | Antimicrobial activity against Enterococcus faecalis JH2-2 harboring nucleotides at position 2576 in rrlA 2576G, rrlB 2576G, rrlC 2576G and rrlD 2576T after 4 passages under Linezolid selective pressure by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Influence of recombination on development of mutational resistance to linezolid in Enterococcus faecalis JH2-2. |
| AID535255 | Antimicrobial activity against vancomycin resistant Staphylococcus aureus VRS-3 expressing SCCmec type 4 element by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | In vitro activity of ceftaroline against community-associated methicillin-resistant, vancomycin-intermediate, vancomycin-resistant, and daptomycin-nonsusceptible Staphylococcus aureus isolates. |
| AID583388 | Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus isolate MU50 assessed as bacterial count at 8 times MIC after 24 hrs by colony counting method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | In vitro activity of the new multivalent glycopeptide-cephalosporin antibiotic TD-1792 against vancomycin-nonsusceptible Staphylococcus isolates. |
| AID285506 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus after 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | In vitro and in vivo antibacterial activities of heteroaryl isothiazolones against resistant gram-positive pathogens. |
| AID283612 | Antimicrobial activity against Enterococcus faecalis 37 with heterozygous 23S rRNA G2576U mutation | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | In vitro activity of the oxazolidinone RWJ-416457 against linezolid-resistant and -susceptible staphylococci and enterococci. |
| AID285387 | Area under population analysis profile for vancomycin-intermediate Staphylococcus aureus Mu50 using in vitro PK/PD model relative to growth control with 120 mg/24 hrs continuous infusion regimen after 72 hrs | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Pharmacokinetic/pharmacodynamic factors influencing emergence of resistance to linezolid in an in vitro model. |
| AID531577 | Antibacterial activity against Gemella spp. obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID576139 | Antibacterial activity against 10'4 to 10'5 CFU Streptococcus pneumoniae after 18 hrs by CLSI 2-fold agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | In vitro and in vivo activities of LCB01-0371, a new oxazolidinone. |
| AID524943 | Antibacterial activity against methicillin-resistant Staphylococcus aureus clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Comparative surveillance study of telavancin activity against recently collected gram-positive clinical isolates from across the United States. |
| AID311484 | Antimicrobial activity against Haemophilus influenzae ATCC 49766 after 14 to 16 hrs by serial micro-broth dilution method | 2007 | Journal of natural products, Sep, Volume: 70, Issue:9 | Lipoxazolidinones A, B, and C: antibacterial 4-oxazolidinones from a marine actinomycete isolated from a Guam marine sediment. |
| AID373800 | Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus 504 after 22 passages by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID511392 | Antibacterial activity against Levofloxacin susceptible Streptococcus pneumoniae by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Comparative in vitro activities of nemonoxacin (TG-873870), a novel nonfluorinated quinolone, and other quinolones against clinical isolates. |
| AID559797 | Antimicrobial activity against vancomycin-susceptible Staphylococcus aureus assessed as growth inhibition at 0.125 times MIC | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID645041 | Antibacterial activity against Staphylococcus aureus ATCC 43300 after 16 to 20 hrs by microbroth dilution method | 2012 | European journal of medicinal chemistry, Apr, Volume: 50 | Synthesis and preliminary antibacterial evaluation of Linezolid-like 1,2,4-oxadiazole derivatives. |
| AID1400750 | Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate 2 after 16 to 18 hrs by broth microdilution method | 2017 | MedChemComm, Apr-01, Volume: 8, Issue:4 | Microwave-enhanced Friedländer synthesis for the rapid assembly of halogenated quinolines with antibacterial and biofilm eradication activities against drug resistant and tolerant bacteria. |
| AID318358 | Antibacterial activity against vancomycin-resistant Enterococcus faecium | 2007 | Proceedings of the National Academy of Sciences of the United States of America, May-01, Volume: 104, Issue:18 | Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties. |
| AID524949 | Antibacterial activity against methicillin-susceptible coagulase-negative Staphylococcus saprophyticus clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Comparative surveillance study of telavancin activity against recently collected gram-positive clinical isolates from across the United States. |
| AID571831 | Antibacterial activity against Ruminococcus obeum by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID206610 | In vitro antibacterial against methicillin-susceptible Staphylococcus aureus (MSSA) | 2003 | Bioorganic & medicinal chemistry letters, Jul-07, Volume: 13, Issue:13 | Synthesis and in vitro activity of new methylenepiperidinyl and methylenepyrrolidinyl oxazolidinone antibacterial agents. |
| AID1407936 | Antibacterial activity against Enterococcus faecalis ATCC 29212 after 24 hrs by broth microdilution method | 2018 | European journal of medicinal chemistry, Sep-05, Volume: 157 | Discovery of dual GyrB/ParE inhibitors active against Gram-negative bacteria. |
| AID531641 | Antimicrobial activity against Enterococcus faecalis ATCC 29212 | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | R chi-01, a new family of oxazolidinones that overcome ribosome-based linezolid resistance. |
| AID210051 | Antibacterial activity against Streptococcus pneumoniae UC9912 | 1998 | Bioorganic & medicinal chemistry letters, May-19, Volume: 8, Issue:10 | Synthesis and antibacterial activity of [6,5,5] and [6,6,5] tricyclic fused oxazolidinones. |
| AID1898409 | Antibiofilm activity against methicillin-resistant Staphylococcus aureus BAA-1707 biofilms assessed as biofilm eradication incubated for 24 hrs followed by incubation for 24 hrs in fresh medium by Calgary biofilm device assay | 2021 | Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11 | A Modular Synthetic Route Involving |
| AID561077 | Antibacterial activity against methicillin-susceptible Staphylococcus epidermidis by CLSI M7-A7 broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | In vitro activity of TR-700, the active ingredient of the antibacterial prodrug TR-701, a novel oxazolidinone antibacterial agent. |
| AID542913 | Antimicrobial activity against Bacillus anthracis infected in in vitro hollow fiber PK/PD model assessed as cell killing followed by emergence of resistance between 4 to 8 days at 500 mg administered once every 24 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID575045 | Nonrenal clearance in healthy human at 600 mg, po | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Therapeutic drug monitoring of linezolid: a retrospective monocentric analysis. |
| AID424757 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus MB2865 after 20 hrs by twofold serial broth dilution method | 2009 | Journal of natural products, May-22, Volume: 72, Issue:5 | Thiazomycins, thiazolyl peptide antibiotics from Amycolatopsis fastidiosa. |
| AID555305 | Antibacterial activity against vancomycin-resistant Staphylococcus aureus VRS1 by broth macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Antistaphylococcal activity of dihydrophthalazine antifolates, a family of novel antibacterial drugs. |
| AID1861532 | Terminal half life in Wistar rat at 30 mg/kg, iv | 2022 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 71 | WCK 4034: A promising oxazolidinone for treating gram positive infections. |
| AID283171 | Decrease in biofilm formation of Staphylococcus lugdunensis assessed as percent biofilm forming isolates | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | In vitro effects of antimicrobial agents on planktonic and biofilm forms of Staphylococcus lugdunensis clinical isolates. |
| AID1594069 | Antibacterial activity against Staphylococcus aureus assessed as reduction in bacterial cell viability incubated for 20 to 24 hrs by REMA method | 2019 | Bioorganic & medicinal chemistry, 06-15, Volume: 27, Issue:12 | Design, synthesis, in-silico studies and biological screening of quinazolinone analogues as potential antibacterial agents against MRSA. |
| AID524970 | Antibacterial activity against vancomycin- and teichoplanin-nonsusceptible Enterococcus faecium clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Comparative surveillance study of telavancin activity against recently collected gram-positive clinical isolates from across the United States. |
| AID587297 | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv after 3 to 4 weeks by microplate alamar blue assay | 2011 | European journal of medicinal chemistry, Mar, Volume: 46, Issue:3 | Anti-tubercular agents. Part 6: synthesis and antimycobacterial activity of novel arylsulfonamido conjugated oxazolidinones. |
| AID1361110 | Bactericidal activity against methicillin-resistant Staphylococcus aureus USA700 NRS386 clinical isolate preincubated for 20 hrs followed by TSA plating and measured after 18 hrs | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | N-(1,3,4-oxadiazol-2-yl)benzamide analogs, bacteriostatic agents against methicillin- and vancomycin-resistant bacteria. |
| AID1168007 | Antibacterial activity against vancomycin-resistant Enterococcus faecium clinical isolate 151495 after overnight incubation by two-fold serial dilution method | 2014 | Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21 | Synthesis and biological evaluation of novel peptide BF2 as an antibacterial agent against clinical isolates of vancomycin-resistant enterococci. |
| AID1687314 | Antibacterial activity against Acinetobacter baumannii ATCC 19606 incubated for 18 to 20 hrs by broth microdilution method | 2020 | European journal of medicinal chemistry, Jan-15, Volume: 186 | Development of benzimidazole-based derivatives as antimicrobial agents and their synergistic effect with colistin against gram-negative bacteria. |
| AID1873888 | Antibacterial activity against Staphylococcus aureus ATCC 29213 incubated for 16 to 20 hrs using 10^7 CFU/ml bacterial inoculum by broth microdilution method | 2022 | European journal of medicinal chemistry, Aug-05, Volume: 238 | Design, synthesis and activity against drug-resistant bacteria evaluation of C-20, C-23 modified 5-O-mycaminosyltylonolide derivatives. |
| AID581015 | Inhibition of protein synthesis in Staphylococcus aureus ATCC 25923 assessed as incorporation of [14C]isoleucine at 2 ug/ml by liquid scintillation counter | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Mode of action of Ranbezolid against staphylococci and structural modeling studies of its interaction with ribosomes. |
| AID1056343 | Cmax in ICR mouse at 67.7 mg/kg, po by LC-MS/MS analysis | 2013 | ACS medicinal chemistry letters, Nov-14, Volume: 4, Issue:11 | Potent oxazolidinone antibacterials with heteroaromatic C-ring substructure. |
| AID1271225 | Antibacterial activity against linezolid-resistant Streptococcus pneumoniae 6303 by microbroth dilution method | 2015 | ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11 | Design, Synthesis, and Identification of Silicon Incorporated Oxazolidinone Antibiotics with Improved Brain Exposure. |
| AID285323 | Antimicrobial activity against Nocardia spp. by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Daptomycin susceptibility of unusual gram-positive bacteria: comparison of results obtained by the Etest and the broth microdilution method. |
| AID559783 | Antimicrobial activity against heterogeneous vancomycin-intermediate Staphylococcus aureus assessed as growth inhibition at 0.125 times MIC | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID1395680 | Antibacterial activity against vancomycin-resistant Staphylococcus aureus VRS10 after 18 hrs by broth microdilution assay | 2018 | European journal of medicinal chemistry, May-10, Volume: 151 | Phenylthiazoles with tert-Butyl side chain: Metabolically stable with anti-biofilm activity. |
| AID564095 | Bactericidal activity against log-phase methicillin-resistant Staphylococcus aureus HUSA 304 after 24 hrs by time kill analysis in presence of 50 mg/L calcium ions | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | Efficacy of high doses of daptomycin versus alternative therapies against experimental foreign-body infection by methicillin-resistant Staphylococcus aureus. |
| AID326280 | Antibacterial activity against methicillin-resistant Staphylococcus aureus 4803 at 4 hrs daily exposure for 1 day by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Comparative activities of daptomycin, linezolid, and tigecycline against catheter-related methicillin-resistant Staphylococcus bacteremic isolates embedded in biofilm. |
| AID283618 | Antimicrobial activity against Enterococcus faecium Ho 4418-0062 with heterozygous 23S rRNA G2576U mutation | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | In vitro activity of the oxazolidinone RWJ-416457 against linezolid-resistant and -susceptible staphylococci and enterococci. |
| AID285037 | Antimicrobial activity against Bacillus spp. by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID83806 | In vitro antibacterial activity against Haemophilus influenzae 11 (Hin) was determined | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | Structure-activity relationship in the oxazolidinone-quinolone hybrid series: influence of the central spacer on the antibacterial activity and the mode of action. |
| AID541811 | Antimicrobial activity against Enterococcus gallinarum clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID519994 | Antimicrobial activity against Streptococcus pneumoniae harboring erm(B) gene by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID126688 | Compound was evaluated for inhibition of Mono aminoxidase B in rat primary hepatocytes | 2002 | Bioorganic & medicinal chemistry letters, Aug-19, Volume: 12, Issue:16 | The synthesis and biological evaluation of a novel series of antimicrobials of the oxazolidinone class. |
| AID533013 | Antibacterial activity against vancomycin-intermediate Staphylococcus aureus BR4 phenotypic revertant after 24 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Improved antimicrobial activity of linezolid against vancomycin-intermediate Staphylococcus aureus. |
| AID1594361 | Antibacterial activity against vancomycin-resistant Staphylococcus aureus VRS10 after 18 to 24 hrs by broth microdilution assay | 2019 | Bioorganic & medicinal chemistry, 05-01, Volume: 27, Issue:9 | Second-generation aryl isonitrile compounds targeting multidrug-resistant Staphylococcus aureus. |
| AID558522 | Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus 1287 measured on day 30 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID583394 | Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus isolate NJ992 assessed as bacterial count at 32 times MIC after 24 hrs by colony counting method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | In vitro activity of the new multivalent glycopeptide-cephalosporin antibiotic TD-1792 against vancomycin-nonsusceptible Staphylococcus isolates. |
| AID1390466 | Antibacterial activity against methicillin-resistant Staphylococcus aureus DB-00026 | 2018 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 28, Issue:7 | Design, synthesis and biological evaluation of spiropyrimidinetriones oxazolidinone derivatives as antibacterial agents. |
| AID516160 | Antibacterial activity against methicillin-resistant Staphylococcus aureus clinical isolates assessed as susceptible isolates by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | In vitro activity of telavancin against a contemporary worldwide collection of Staphylococcus aureus isolates. |
| AID1400050 | Bactericidal activity against Clostridium difficile ATCC 700057 incubated for 24 hrs under aerobic condition by MABA | 2018 | Bioorganic & medicinal chemistry, 09-15, Volume: 26, Issue:17 | An antimycobacterial pleuromutilin analogue effective against dormant bacilli. |
| AID285013 | Antimicrobial activity against Enterococcus raffinosus at <= 0.06 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID522901 | Antibacterial activity against vancomycin-intermediate Staphylococcus aureus isolate 511 after 24 hrs by modified broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Antistaphylococcal activity of ACHN-490 tested alone and in combination with other agents by time-kill assay. |
| AID1680036 | Hemolytic activity in sheep RBC incubated for 1 hr | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Synthesis and antibacterial bioactivities of cationic deacetyl linezolid amphiphiles. |
| AID246828 | Efficacy against mice infected with MRSA-32 upon s.c. administration | 2005 | Journal of medicinal chemistry, Aug-11, Volume: 48, Issue:16 | A chiral benzoquinolizine-2-carboxylic acid arginine salt active against vancomycin-resistant Staphylococcus aureus. |
| AID483195 | Antibacterial activity against Escherichia coli ATCC 25922 by microbroth dilution technique | 2010 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 20, Issue:12 | Design, synthesis, and antibacterial activity of 2,5-dihydropyrrole formyl hydroxyamino derivatives as novel peptide deformylase inhibitors. |
| AID531567 | Antibacterial activity against Streptococcus agalactiae obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID383740 | Cmax in Sprague-Dawley rat at 25 mg/kg, po | 2008 | European journal of medicinal chemistry, Apr, Volume: 43, Issue:4 | Synthesis and in vitro antibacterial activities of novel oxazolidinones. |
| AID410207 | Antibacterial activity against vancomycin and linezolid-resistant Enterococcus faecalis by broth micro dilution method | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24 | A facile synthesis, antibacterial, and antitubercular studies of some piperidin-4-one and tetrahydropyridine derivatives. |
| AID555304 | Antibacterial activity against methicillin-resistant Staphylococcus aureus 507 by broth macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Antistaphylococcal activity of dihydrophthalazine antifolates, a family of novel antibacterial drugs. |
| AID560798 | Elimination rate constant in human adults with pulmonary tuberculosis at 600 mg administered daily for 7 days | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Population pharmacokinetics of linezolid in adults with pulmonary tuberculosis. |
| AID285156 | Antimicrobial activity against Streptococcus pneumoniae ATCC 49619 | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Clonal diversity and resistance mechanisms in tetracycline-nonsusceptible Streptococcus pneumoniae isolates in Poland. |
| AID573152 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID559551 | Antimicrobial activity against compound-intermediate susceptible Coxiella burnetii isolate CP4 obtained from patient with acute Q fever infected in african green monkey Vero cells after 24 hrs by shell vial assay | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Bacteriostatic and bactericidal activities of tigecycline against Coxiella burnetii and comparison with those of six other antibiotics. |
| AID558729 | Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus 555 measured on day 50 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID511436 | Antimicrobial activity against multidrug-resistant flogene-deficient Clostridium perfringens LFM1 harboring single C>T at bp 404 of rplD gene | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Resistance to linezolid in a porcine Clostridium perfringens strain carrying a mutation in the rplD gene encoding the ribosomal protein L4. |
| AID524681 | Antibacterial activity against methicillin-resistant Staphylococcus aureus clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro antibacterial activity of CE-156811, a novel analog derived from hygromycin A. |
| AID1578416 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus NRS 386 by broth liquid microdilution method | 2020 | European journal of medicinal chemistry, Jan-01, Volume: 185 | Modifying the lipophilic part of phenylthiazole antibiotics to control their drug-likeness. |
| AID574075 | Clearance in CF-1 mouse at 2 mg/kg, iv | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | In vivo activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. |
| AID576401 | Residual concentration at the end of the administration interval in two-compartment pharmacokinetic/pharmacodynamic model at 800 mg, bid administered as 0.5 hrs infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID561249 | Antibacterial activity against Streptococcus pneumoniae by CLSI M100-S17 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | AFN-1252, a FabI inhibitor, demonstrates a Staphylococcus-specific spectrum of activity. |
| AID575265 | Antimicrobial activity against methicillin-susceptible Staphylococcus epidermidis by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Comparative in vitro activity profiles of novel bis-indole antibacterials against gram-positive and gram-negative clinical isolates. |
| AID1680057 | Antibacterial activity against methicillin-resistant Staphylococcus aureus clinical isolate 8 assessed as reduction in bacterial growth incubated for 16 to 20 hrs by CLSI-based broth microdilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Synthesis and antibacterial bioactivities of cationic deacetyl linezolid amphiphiles. |
| AID1770359 | Ratio of MBC to MIC against penicillin-susceptible Bacillus subtilis ATCC 9372 | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Modification of 5-methylphenanthridium from benzothiazoles to indoles as potent FtsZ inhibitors: Broadening the antibacterial spectrum toward vancomycin-resistant enterococci. |
| AID404948 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus isolate assessed as susceptible resistant isolates by CLSI dilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro activities of CG400549, a novel FabI inhibitor, against recently isolated clinical staphylococcal strains in Korea. |
| AID352929 | Antibacterial activity against methicillin-resistant Staphylococcus aureus after 18 to 20 hrs by agar dilution method | 2009 | Bioorganic & medicinal chemistry letters, May-01, Volume: 19, Issue:9 | Synthesis and antibacterial activities of novel oxazolidinones having spiro[2,4]heptane moieties. |
| AID1241210 | Binding affinity to 5'-FAM-pre-miR-17 (unknown origin) after 4 hrs by fluorescence assay | 2015 | Bioorganic & medicinal chemistry, Sep-01, Volume: 23, Issue:17 | Ribosome-targeting antibiotics as inhibitors of oncogenic microRNAs biogenesis: Old scaffolds for new perspectives in RNA targeting. |
| AID555292 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Antistaphylococcal activity of dihydrophthalazine antifolates, a family of novel antibacterial drugs. |
| AID1167733 | Antimicrobial activity against methicillin-sensitive Staphylococcus aureus by broth microdilution method | 2014 | Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21 | Novel DNA gyrase inhibiting spiropyrimidinetriones with a benzisoxazole scaffold: SAR and in vivo characterization. |
| AID323791 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus Xen29 infected neutropenic CD1 mouse assessed as mortality at 100 mg/kg, po within 24 hrs | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Rapid bactericidal activity of daptomycin against methicillin-resistant and methicillin-susceptible Staphylococcus aureus peritonitis in mice as measured with bioluminescent bacteria. |
| AID369438 | Antimicrobial activity against methicillin-resistant coagulase-negative Staphylococcus after 20 to 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vitro activity of telavancin against gram-positive clinical isolates recently obtained in Europe. |
| AID542672 | fCmax in Bacillus anthracis infected in vitro hollow fiber PK/PD model at simulated dose of 100 mg administered every 24 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID582811 | Antimicrobial activity against glycopeptide-resistant Enterococcus faecalis isolate HS05446 harboring MLST sequence type ST17 and pulsotype B expressing vanA gene cluster isolated from urine of patient by Etest | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | vanM, a new glycopeptide resistance gene cluster found in Enterococcus faecium. |
| AID637975 | Antibacterial activity against Staphylococcus aureus after overnight incubation by twofold broth dilution technique | 2012 | Bioorganic & medicinal chemistry, Jan-01, Volume: 20, Issue:1 | Efficient microwave-assisted synthesis, antibacterial activity and high fluorescence of 5 benzimidazolyl-2'-deoxyuridines. |
| AID645034 | Antibacterial activity against erythromycin-resistant Streptococcus pyogenes 24 after 16 to 20 hrs by microbroth dilution method | 2012 | European journal of medicinal chemistry, Apr, Volume: 50 | Synthesis and preliminary antibacterial evaluation of Linezolid-like 1,2,4-oxadiazole derivatives. |
| AID533424 | Antimicrobial activity against Anaerococcus prevotii assessed as resistant isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activities of doripenem, a new broad-spectrum carbapenem, against recently collected clinical anaerobic isolates, with emphasis on the Bacteroides fragilis group. |
| AID533389 | Antimicrobial activity against Clostridium perfringens by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activities of doripenem, a new broad-spectrum carbapenem, against recently collected clinical anaerobic isolates, with emphasis on the Bacteroides fragilis group. |
| AID1596565 | Bactericidal activity against vancomycin resistant Staphylococcus aureus VRS11a assessed as reduction in bacterial cell growth incubated for 18 to 20 hrs followed by re-plating on tryptic soy agar plates at 37 degC for 18 hrs by broth microdilution assay | 2019 | European journal of medicinal chemistry, Aug-01, Volume: 175 | Lipophilic efficient phenylthiazoles with potent undecaprenyl pyrophosphatase inhibitory activity. |
| AID353059 | Antibacterial activity against vancomycin-resistant Enterococcus 2 after 18 to 20 hrs by agar dilution method | 2009 | Bioorganic & medicinal chemistry letters, May-01, Volume: 19, Issue:9 | Synthesis and antibacterial activities of novel oxazolidinones having spiro[2,4]heptane moieties. |
| AID442573 | Antibacterial activity against methicillin resistant Staphylococcus aureus ATCC 70069 after 24 hrs by spectrophotometry | 2010 | European journal of medicinal chemistry, Feb, Volume: 45, Issue:2 | Synthesis of nitroimidazole derived oxazolidinones as antibacterial agents. |
| AID561082 | Antibacterial activity against vancomycin-resistant Enterococcus faecium by CLSI M7-A7 broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | In vitro activity of TR-700, the active ingredient of the antibacterial prodrug TR-701, a novel oxazolidinone antibacterial agent. |
| AID574956 | Antimicrobial activity against multiple drug resistant Streptococcus pneumoniae serotype 6B by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID1241209 | Binding affinity to 5'-FAM-pre-miR-372 (unknown origin) after 4 hrs by fluorescence assay | 2015 | Bioorganic & medicinal chemistry, Sep-01, Volume: 23, Issue:17 | Ribosome-targeting antibiotics as inhibitors of oncogenic microRNAs biogenesis: Old scaffolds for new perspectives in RNA targeting. |
| AID391590 | Antibacterial activity against methicillin-resistant Staphylococcus aureus TK7 by agar dilution method | 2008 | Journal of medicinal chemistry, Oct-23, Volume: 51, Issue:20 | Synthesis and structure-activity relationship studies of highly potent novel oxazolidinone antibacterials. |
| AID534160 | Antimicrobial activity against linezolid-resistant Enterococcus faecium by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains. |
| AID283164 | Antimicrobial susceptibility of Staphylococcus lugdunensis IDRL2640 biofilms after 24 hrs assessed as bacterial regrowth | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | In vitro effects of antimicrobial agents on planktonic and biofilm forms of Staphylococcus lugdunensis clinical isolates. |
| AID285378 | Bactericidal activity against vancomycin-resistant Enterococcus faecium ATCC 700221 assessed as reduction of CFU using in vitro PK/PD model with human dosage regimen 600 mg every 12 hrs at 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Pharmacokinetic/pharmacodynamic factors influencing emergence of resistance to linezolid in an in vitro model. |
| AID278919 | Antibacterial activity against linezolid-resistant Enterococcus gallinarum | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | In vitro antibacterial activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. |
| AID567487 | Antimicrobial activity against linezolid pretreated vancomycin-intermediate Staphylococcus aureus isolate 2 obtained from blood of patient by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Clinical outcomes by methicillin-resistant Staphylococcus aureus staphylococcal cassette chromosome mec type: isolates recovered from a phase IV clinical trial of linezolid and vancomycin for complicated skin and skin structure infections. |
| AID404952 | Antibacterial activity against methicillin-susceptible coagulase-negative Staphylococcus sp. assessed as percent susceptible isolates by CLSI dilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro activities of CG400549, a novel FabI inhibitor, against recently isolated clinical staphylococcal strains in Korea. |
| AID284989 | Antimicrobial activity against Enterococcus casseliflavus at 0.25 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID373312 | Antibacterial activity against Streptococcus pneumoniae clinical isolate after 18 hrs by NCCLS M7-A4 method | 2009 | European journal of medicinal chemistry, Mar, Volume: 44, Issue:3 | Synthesis, antibacterial and anticonvulsant evaluations of some cyclic enaminones. |
| AID1308223 | Antibacterial activity against mecA-positive methicillin/oxacillin/tetracycline-resistant Staphylococcus aureus ATCC 27660 incubated for 16 to 20 hrs by microdilution method | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10 | Structure-Activity Relationship for the 4(3H)-Quinazolinone Antibacterials. |
| AID1451775 | Antibacterial activity against Staphylococcus aureus NRS271 infected in BALB/c mouse assessed as reduction of bacterial burden in liver at 0.4 mg, ip bid for 4.5 days administered 6 hrs post bacterial infection measured 108 hrs post infection relative to | 2017 | Journal of medicinal chemistry, 10-12, Volume: 60, Issue:19 | Novel Inhibitors of Staphyloxanthin Virulence Factor in Comparison with Linezolid and Vancomycin versus Methicillin-Resistant, Linezolid-Resistant, and Vancomycin-Intermediate Staphylococcus aureus Infections in Vivo. |
| AID1504626 | Antibacterial activity against Haemophilus influenzae ATCC 49247 by microbroth dilution method | 2017 | ACS medicinal chemistry letters, Nov-09, Volume: 8, Issue:11 | Design, Synthesis, and Antibacterial Evaluation of Oxazolidinones with Fused Heterocyclic C-Ring Substructure. |
| AID1557269 | Antitubercular activity against resistant Mycobacterium tuberculosis harboring rplC Cys154Arg mutant | 2019 | MedChemComm, Aug-01, Volume: 10, Issue:8 | Drug-resistance in |
| AID405620 | Antibacterial activity against Streptococcus | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Comparative study of the effects of pyridoxine, rifampin, and renal function on hematological adverse events induced by linezolid. |
| AID319155 | Toxicity in rat at 50 mg/kg, po for 30 days | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7 | Linezolid (ZYVOX), the first member of a completely new class of antibacterial agents for treatment of serious gram-positive infections. |
| AID1421237 | Intrinsic clearance in human liver microsomes at 1.5 uM pretreated for 5 mins followed by NADPH addition measured after 5 to 45 mins by LC-MS analysis | 2018 | European journal of medicinal chemistry, Oct-05, Volume: 158 | Synthesis and antibacterial activity evaluation of novel biaryloxazolidinone analogues containing a hydrazone moiety as promising antibacterial agents. |
| AID534251 | Bacteriostatic activity against linezolid-susceptible Staphylococcus aureus SA238 infected in THP1 cells at pH 5.5 after 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Cellular pharmacodynamics of the novel biaryloxazolidinone radezolid: studies with infected phagocytic and nonphagocytic cells, using Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Legionella pneumophila. |
| AID583877 | Antibacterial activity against laboratory-derived Staphylococcus aureus isolate 29213-3 harboring ribosomal protein L3 deltaPhe127-His146 mutant by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Elevated linezolid resistance in clinical cfr-positive Staphylococcus aureus isolates is associated with co-occurring mutations in ribosomal protein L3. |
| AID1271204 | Solubility of compound at pH 2.2 by HPLC analysis | 2015 | ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11 | Design, Synthesis, and Identification of Silicon Incorporated Oxazolidinone Antibiotics with Improved Brain Exposure. |
| AID1390487 | Antibacterial activity against linezolid-resistant Enterococcus faecium 303 | 2018 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 28, Issue:7 | Design, synthesis and biological evaluation of spiropyrimidinetriones oxazolidinone derivatives as antibacterial agents. |
| AID1409842 | Antibacterial activity against Staphylococcus aureus Newman infected in BALB/c mouse assessed as reduction of bacterial burden in liver at 0.4 mg, ip bid administered at 12 hrs prior to bacterial infection dosed at 12 intervals for 4.5 days relative to co | 2018 | ACS medicinal chemistry letters, Mar-08, Volume: 9, Issue:3 | Novel Staphyloxanthin Inhibitors with Improved Potency against Multidrug Resistant |
| AID561093 | Antibacterial activity against Bacteroides ovatus by CLSI M11-A7 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | In vitro activity of TR-700, the active ingredient of the antibacterial prodrug TR-701, a novel oxazolidinone antibacterial agent. |
| AID575944 | Antimicrobial activity against erythromycin-resistant Streptococcus pneumoniae by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Distribution of serotypes, genotypes, and resistance determinants among macrolide-resistant Streptococcus pneumoniae isolates. |
| AID1584844 | Antibacterial activity against hospital-acquired methicillin and vacomycin resistant Staphylococcus aureus VRS-1 after 18 to 24 hrs by microdilution assay | 2018 | European journal of medicinal chemistry, Nov-05, Volume: 159 | 1-(2-Hydroxybenzoyl)-thiosemicarbazides are promising antimicrobial agents targeting d-alanine-d-alanine ligase in bacterio. |
| AID1168015 | Antibacterial activity against vancomycin-resistant Enterococcus faecium clinical isolate 12875 after overnight incubation by two-fold serial dilution method | 2014 | Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21 | Synthesis and biological evaluation of novel peptide BF2 as an antibacterial agent against clinical isolates of vancomycin-resistant enterococci. |
| AID583890 | Antibacterial activity against hospital-associated methicillin-resistant Staphylococcus aureus isolate 412 by broth microdilution assay | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Comparative efficacies of human simulated exposures of telavancin and vancomycin against methicillin-resistant Staphylococcus aureus with a range of vancomycin MICs in a murine pneumonia model. |
| AID533958 | Antimicrobial activity against Legionella pneumophila ATCC 33153 infected in THP1 cells assessed as log reduction in bacterial count after 48 hrs | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Cellular pharmacodynamics of the novel biaryloxazolidinone radezolid: studies with infected phagocytic and nonphagocytic cells, using Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Legionella pneumophila. |
| AID520769 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus infected in New Zealand rabbit osteomyelitis model assessed as bacterial count per gram of tibial matrix at 60 mg/kg, po administered every 8 hrs for 4 weeks measured on week 8 pos | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Efficacies of ceftobiprole medocaril and comparators in a rabbit model of osteomyelitis due to methicillin-resistant Staphylococcus aureus. |
| AID542389 | Antimicrobial activity against Staphylococcus aureus RN4220 transformed with Staphylococcus aureus ST9 plasmid pSCFS3 carrying cfr and fexA genes | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Methicillin-resistant and -susceptible Staphylococcus aureus strains of clonal lineages ST398 and ST9 from swine carry the multidrug resistance gene cfr. |
| AID1907631 | Antibacterial activity against Pseudomonas aeruginosa incubated for 18 to 20 hrs by double dilution method | 2022 | European journal of medicinal chemistry, Jun-05, Volume: 236 | Novel benzothiazole‒urea hybrids: Design, synthesis and biological activity as potent anti-bacterial agents against MRSA. |
| AID563329 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis EF NJ1 infected in New Zealand White rabbit assessed as reduction of bacterial count in aortic valve vegetations at 10 mg/kg, administered through ear vein every 12 hrs for 4 days ( | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | In vivo activity of a novel anti-methicillin-resistant Staphylococcus aureus cephalosporin, ceftaroline, against vancomycin-susceptible and -resistant Enterococcus faecalis strains in a rabbit endocarditis model: a comparative study with linezolid and van |
| AID1151755 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae isolate 0613 | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID560808 | Elimination rate constant in human adults with pulmonary tuberculosis at 600 mg administered twice daily for 7 days | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Population pharmacokinetics of linezolid in adults with pulmonary tuberculosis. |
| AID520616 | Antimicrobial activity against Nocardia brasiliensis HUJEG-1 infected in BALB/c mouse assessed as decrease in number of lesions on foot-pad at 25 mg/kg, sc TID for 4 weeks | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | In vivo therapeutic effect of gatifloxacin on BALB/c mice infected with Nocardia brasiliensis. |
| AID1241206 | Inhibition of pre-miR-17 (unknown origin) cleavage assessed as reduction of oncogenic microRNAs biogenesis by measuring fluorescence every minute for 5 hrs using 5'-FAM,3'-dabcyl-pre-miRNA beacons by FRET assay in presence of recombinant Dicer | 2015 | Bioorganic & medicinal chemistry, Sep-01, Volume: 23, Issue:17 | Ribosome-targeting antibiotics as inhibitors of oncogenic microRNAs biogenesis: Old scaffolds for new perspectives in RNA targeting. |
| AID1493809 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis ATCC 51299 after 20 hrs by broth microdilution method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Biphenylthiazole antibiotics with an oxadiazole linker: An approach to improve physicochemical properties and oral bioavailability. |
| AID1350038 | Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate 9 incubated overnight by agar dilution method | 2018 | Journal of natural products, 02-23, Volume: 81, Issue:2 | Biomimetic Stereoselective Sulfa-Michael Addition Leads to Platensimycin and Platencin Sulfur Analogues against Methicillin-Resistant Staphylococcus aureus. |
| AID263966 | Antibacterial activity against beta lactamase negative Moraxella catarrhalis DRCC 300 | 2006 | Bioorganic & medicinal chemistry letters, May-01, Volume: 16, Issue:9 | Synthesis and antibacterial activity of novel oxazolidinones bearing N-hydroxyacetamidine substituent. |
| AID424616 | Antibacterial activity against Enterococcus avium AIS2007004 isolated from patients rectum by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Vancomycin-resistant Staphylococcus aureus isolates associated with Inc18-like vanA plasmids in Michigan. |
| AID529682 | Antimicrobial activity against hospital-acquired methicillin-resistant Staphylococcus aureus by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Activities of ceftobiprole, linezolid, vancomycin, and daptomycin against community-associated and hospital-associated methicillin-resistant Staphylococcus aureus. |
| AID524981 | Antibacterial activity against Streptococcus oralis clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Comparative surveillance study of telavancin activity against recently collected gram-positive clinical isolates from across the United States. |
| AID1760590 | Antibacterial activity against Escherichia coli 29212 assessed as inhibition of bacterial growth measured after 24 hrs | 2021 | European journal of medicinal chemistry, Feb-05, Volume: 211 | Installation of an aryl boronic acid function into the external section of N-aryl-oxazolidinones: Synthesis and antimicrobial evaluation. |
| AID1852670 | Antibacterial activity against multidrug resistant Pseudomonas aeruginosa BAA 2108 assessed as inhibition of bacterial growth incubated for 24 hrs in M9-MOPS medium by twofold serial dilution method | |||
| AID1473738 | Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to 20 mins by membrane vesicle transport assay | 2013 | Toxicological sciences : an official journal of the Society of Toxicology, Nov, Volume: 136, Issue:1 | A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. |
| AID326501 | Antibacterial activity against vancomycin-susceptible Enterococcus faecalis 309 after 24 hrs by broth macrodilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Single-dose oral amoxicillin or linezolid for prophylaxis of experimental endocarditis due to vancomycin-susceptible and vancomycin-resistant Enterococcus faecalis. |
| AID373651 | Antimicrobial activity against panton-valentine leukocidin-negative community-acquired methicillin-resistant Staphylococcus aureus 481 by agar dilution CLSI method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID565744 | Antimicrobial activity against Enterococcus faecium expressing VanA gene clinical isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID584972 | Antibacterial activity against wild type Mycobacterium smegmatis after 24 generation times | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Mutations in 23S rRNA at the peptidyl transferase center and their relationship to linezolid binding and cross-resistance. |
| AID1168021 | Antibacterial activity against vancomycin-resistant Enterococcus faecium clinical isolate 16475 after overnight incubation by two-fold serial dilution method | 2014 | Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21 | Synthesis and biological evaluation of novel peptide BF2 as an antibacterial agent against clinical isolates of vancomycin-resistant enterococci. |
| AID285146 | Antimicrobial activity against viridans group Streptococcus constellatus by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID519485 | Antibacterial activity against Staphylococcus aureus T1887 expressing 23S rrn3 G2576T mutant by Etest method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Linezolid resistance in Staphylococcus aureus: gene dosage effect, stability, fitness costs, and cross-resistances. |
| AID348863 | Antibacterial activity against vancomycin-resistant Enterococcus 4 after 18 to 20 hrs by agar dilution method | 2008 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 18, Issue:21 | Synthesis and antibacterial activities of novel oxazolidinones having cyclic sulfonamide moieties. |
| AID524977 | Antibacterial activity against Streptococcus bovis clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Comparative surveillance study of telavancin activity against recently collected gram-positive clinical isolates from across the United States. |
| AID531578 | Antibacterial activity against Lactococcus lactis obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID630556 | Antibacterial activity against methicillin-resistant Staphylococcus epidermidis after 16 hrs by agar dilution method | 2011 | Journal of medicinal chemistry, Nov-10, Volume: 54, Issue:21 | Design, synthesis, and structure-activity relationship studies of highly potent novel benzoxazinyl-oxazolidinone antibacterial agents. |
| AID326289 | Antibacterial activity against methicillin-resistant Staphylococcus aureus 789 at 4 hrs daily exposure for 1 day by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Comparative activities of daptomycin, linezolid, and tigecycline against catheter-related methicillin-resistant Staphylococcus bacteremic isolates embedded in biofilm. |
| AID326297 | Antibacterial activity against methicillin-resistant Staphylococcus aureus 4342 at 4 hrs daily exposure for 5 days by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Comparative activities of daptomycin, linezolid, and tigecycline against catheter-related methicillin-resistant Staphylococcus bacteremic isolates embedded in biofilm. |
| AID373659 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus 540 by agar dilution CLSI method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID519093 | Antimicrobial activity against Staphylococcus aureus NRS119 clinical isolate harboring G2576U mutation in 23S rRNA by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Linezolid and tiamulin cross-resistance in Staphylococcus aureus mediated by point mutations in the peptidyl transferase center. |
| AID566582 | Antimicrobial activity against Staphylococcus warneri ATCC 27836 by conventional agar-dilution method | 2011 | European journal of medicinal chemistry, Jan, Volume: 46, Issue:1 | Discovery of a novel nitroimidazolyl-oxazolidinone hybrid with potent anti Gram-positive activity: Synthesis and antibacterial evaluation. |
| AID67753 | Minimum inhibitory concentration against Enterococcus faecalis ATTCC 29212 | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | Synthesis and antibacterial activity of pyrroloaryl-substituted oxazolidinones. |
| AID1393951 | Antibacterial activity against methicillin resistant Staphylococcus epidermidis ATCC 51625 after 16 to 20 hrs by CLSI method | 2018 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 28, Issue:16 | 3-Hydroxy-1,5-dihydro-2H-pyrrol-2-ones as novel antibacterial scaffolds against methicillin-resistant Staphylococcus aureus. |
| AID442572 | Antibacterial activity against floxacin and methicillin-resistant Staphylococcus aureus ATCC 25923 after 24 hrs by spectrophotometry | 2010 | European journal of medicinal chemistry, Feb, Volume: 45, Issue:2 | Synthesis of nitroimidazole derived oxazolidinones as antibacterial agents. |
| AID1197127 | Antibacterial activity against Enterococcus faecalis ATCC 29212 after 16 to 20 hrs by broth microdilution method | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3 | Structure-activity relationship for the oxadiazole class of antibiotics. |
| AID1390468 | Antibacterial activity against Staphylococcus aureus Mu50 ATCC 700699 | 2018 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 28, Issue:7 | Design, synthesis and biological evaluation of spiropyrimidinetriones oxazolidinone derivatives as antibacterial agents. |
| AID560508 | Antimicrobial activity against SCCmec type III vancomycin-intermediate Staphylococcus aureus isolate b3k5923 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID1350039 | Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate 10 incubated overnight by agar dilution method | 2018 | Journal of natural products, 02-23, Volume: 81, Issue:2 | Biomimetic Stereoselective Sulfa-Michael Addition Leads to Platensimycin and Platencin Sulfur Analogues against Methicillin-Resistant Staphylococcus aureus. |
| AID373999 | Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus 555 Hershey after 50 passages with daptomycin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID1400055 | Antibacterial activity against Acinetobacter baumannii ATCC 19606 incubated for 24 hrs under aerobic condition by MABA | 2018 | Bioorganic & medicinal chemistry, 09-15, Volume: 26, Issue:17 | An antimycobacterial pleuromutilin analogue effective against dormant bacilli. |
| AID285370 | Antibacterial activity against heteroresistant vancomycin-intermediate Staphylococcus aureus Mu3 by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Pharmacokinetic/pharmacodynamic factors influencing emergence of resistance to linezolid in an in vitro model. |
| AID1304854 | Aqueous solubility of compound in media after 16 hrs | 2016 | Journal of medicinal chemistry, 04-28, Volume: 59, Issue:8 | Structure-Activity Relationships of a Diverse Class of Halogenated Phenazines That Targets Persistent, Antibiotic-Tolerant Bacterial Biofilms and Mycobacterium tuberculosis. |
| AID561095 | Antibacterial activity against Peptostreptococcus anaerobius by CLSI M11-A7 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | In vitro activity of TR-700, the active ingredient of the antibacterial prodrug TR-701, a novel oxazolidinone antibacterial agent. |
| AID530124 | Antimicrobial activity against community acquired methicillin-resistant Staphylococcus aureus 147 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Pharmacodynamic characterization of ceftobiprole in experimental pneumonia caused by phenotypically diverse Staphylococcus aureus strains. |
| AID576422 | AUC in healthy human at 600 mg, iv, bid administered as 0.5 hr infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID528718 | Antibacterial activity against vancomycin resistant Enterococcus faecium VanB clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID474996 | Antibacterial activity against Staphylococcus aureus LCB0001 by two fold serial dilution method | 2010 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 20, Issue:7 | Synthesis, crystal and antibacterial studies of diversely functionalized tetrahydropyridin-4-ol. |
| AID528736 | Antibacterial activity against methicillin resistant coagulase-negative Staphylococcus auricularis clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID561268 | Antibacterial activity against Enterococcus faecium assessed as resistant isolates by CLSI M100-S17 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | AFN-1252, a FabI inhibitor, demonstrates a Staphylococcus-specific spectrum of activity. |
| AID1327120 | Antitubercular activity against dormant stage Mycobacterium bovis BCG ATCC 35734 at 30 ug/ml measured after 12 days by nitrate reductase assay | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Design, synthesis and biological evaluation of novel azaspiro analogs of linezolid as antibacterial and antitubercular agents. |
| AID278926 | Antibacterial activity against Moraxella catarrhalis | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | In vitro antibacterial activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. |
| AID374017 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus 525 after single-step resistance selection by agar dilution CLSI method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID1680013 | Antibiofilm activity against 24 hrs preformed biofilm of Staphylococcus aureus ATCC 29213 assessed as eradication of preformed biofilm incubated for 24 hrs by crystal violet staining assay | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Synthesis and antibacterial bioactivities of cationic deacetyl linezolid amphiphiles. |
| AID1161139 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus after 24 hrs by broth microdilution method | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | Synthesis, antibacterial activity, and biological evaluation of formyl hydroxyamino derivatives as novel potent peptide deformylase inhibitors against drug-resistant bacteria. |
| AID303972 | Antibacterial activity against methicillin-resistant Staphylococcus aureus SA1417 in po dosed CD1 mouse systemic infection model assessed as mortality after 7 days | 2007 | Journal of medicinal chemistry, Nov-29, Volume: 50, Issue:24 | Antibacterial oxazolidinones possessing a novel C-5 side chain. (5R)-trans-3-[3-Fluoro-4- (1-oxotetrahydrothiopyran-4-yl)phenyl]-2- oxooxazolidine-5-carboxylic acid amide (PF-00422602), a new lead compound. |
| AID1684998 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 assessed as inhibition of bacterial growth incubated for 16 to 20 hrs by microdilution method | 2021 | ACS medicinal chemistry letters, Jan-14, Volume: 12, Issue:1 | Enhancing Antimicrobial Peptide Potency through Multivalent Presentation on Coiled-Coil Nanofibrils. |
| AID1904919 | Antibacterial activity against methicillin-resistant Staphylococcus aureus NRS 386 (USA700) incubated for 18 to 20 hrs by broth microdilution method | 2022 | European journal of medicinal chemistry, Apr-15, Volume: 234 | Exploring the structure-activity relationships of diphenylurea as an antibacterial scaffold active against methicillin- and vancomycin-resistant Staphylococcus aureus. |
| AID1659809 | Antimycobacterial activity against Mycobacterium tuberculosis | 2020 | Journal of medicinal chemistry, 09-10, Volume: 63, Issue:17 | Molecule Property Analyses of Active Compounds for |
| AID522907 | Antibacterial activity against vancomycin-intermediate Staphylococcus aureus isolate 1007 after 24 hrs by modified broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Antistaphylococcal activity of ACHN-490 tested alone and in combination with other agents by time-kill assay. |
| AID562634 | Antimicrobial activity against Corynebacterium spp. by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | In vitro activities of three new dihydrofolate reductase inhibitors against clinical isolates of gram-positive bacteria. |
| AID1594365 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae ATCC 700677 after 18 to 24 hrs by broth microdilution assay | 2019 | Bioorganic & medicinal chemistry, 05-01, Volume: 27, Issue:9 | Second-generation aryl isonitrile compounds targeting multidrug-resistant Staphylococcus aureus. |
| AID424761 | Antibacterial activity against vancomycin-intermediate, macrolide, methicillin-resistant Staphylococcus aureus CL5706 after 20 hrs by twofold serial broth dilution method | 2009 | Journal of natural products, May-22, Volume: 72, Issue:5 | Thiazomycins, thiazolyl peptide antibiotics from Amycolatopsis fastidiosa. |
| AID558701 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus 525 measured on day 35 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID562618 | Antimicrobial activity against Heterovancomycin-resistant Staphylococcus aureus by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | In vitro activities of three new dihydrofolate reductase inhibitors against clinical isolates of gram-positive bacteria. |
| AID1374165 | Antibacterial activity against Staphylococcus aureus ATCC 25923 incubated at 37 degC for 20 hrs by standard broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4 | Design, synthesis and antibacterial evaluation of honokiol derivatives. |
| AID369439 | Antimicrobial activity against vancomycin-susceptible Enterococcus faecalis after 20 to 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vitro activity of telavancin against gram-positive clinical isolates recently obtained in Europe. |
| AID1151745 | Antibacterial activity against Staphylococcus aureus measured after 7 serial passages | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID1770365 | Bactericidal activity against Vancomycin-susceptible Enterococcus faecium ATCC 19434 assessed as inhibition of bacterial growth measured after 20 hrs by two-fold microdilution assay | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Modification of 5-methylphenanthridium from benzothiazoles to indoles as potent FtsZ inhibitors: Broadening the antibacterial spectrum toward vancomycin-resistant enterococci. |
| AID524947 | Antibacterial activity against methicillin-susceptible coagulase-negative Staphylococcus haemolyticus clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Comparative surveillance study of telavancin activity against recently collected gram-positive clinical isolates from across the United States. |
| AID1866043 | Antibacterial activity against methicillin-resistant Staphylococcus aureus in in-vivo systemic infection model | 2022 | Bioorganic & medicinal chemistry, 02-15, Volume: 56 | Structural modification aimed for improving solubility of lead compounds in early phase drug discovery. |
| AID549537 | Apparent permeability from basolateral to apical side of MDCK cells | 2011 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1 | MDCK cell permeability characteristics of a sulfenamide prodrug: strategic implications in considering sulfenamide prodrugs for oral delivery of NH-acids. |
| AID428280 | Antituberculosis activity against linezolid-resistant Mycobacterium tuberculosis having mutation in 23S rRNA with G to T base pair exchange at position 2576 | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro-selected linezolid-resistant Mycobacterium tuberculosis mutants. |
| AID562185 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus 543 after 15 passages by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID524721 | Antibacterial activity against linezolid-resistant Enterococcus faecalis 03A1128 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro antibacterial activity of CE-156811, a novel analog derived from hygromycin A. |
| AID533007 | Antibacterial activity against vancomycin-intermediate Staphylococcus aureus 99/3700-W phenotypic revertant after 24 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Improved antimicrobial activity of linezolid against vancomycin-intermediate Staphylococcus aureus. |
| AID558501 | Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus 555 measured on day 20 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID1304837 | Antibacterial activity against vancomycin-resistant Enterococcus faecium ATCC 700221 incubated for 16 to 18 hrs by broth microdilution method | 2016 | Journal of medicinal chemistry, 04-28, Volume: 59, Issue:8 | Structure-Activity Relationships of a Diverse Class of Halogenated Phenazines That Targets Persistent, Antibiotic-Tolerant Bacterial Biofilms and Mycobacterium tuberculosis. |
| AID564821 | Antimicrobial activity against methicillin-resistant coagulase-negative Staphylococcus hominis after 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID1060727 | Antibacterial activity against Staphylococcus aureus harboring FtsZ G196A mutant by broth microdilution method | 2014 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 24, Issue:1 | Design, synthesis and structure-activity relationships of substituted oxazole-benzamide antibacterial inhibitors of FtsZ. |
| AID326291 | Antibacterial activity against methicillin-resistant Staphylococcus aureus 4913 at 4 hrs daily exposure for 5 days by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Comparative activities of daptomycin, linezolid, and tigecycline against catheter-related methicillin-resistant Staphylococcus bacteremic isolates embedded in biofilm. |
| AID534157 | Antimicrobial activity against linezolid-resistant Staphylococcus aureus by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains. |
| AID67579 | Minimum inhibitory concentration against Enterococcus faecalis UC9217 | 1998 | Journal of medicinal chemistry, Sep-10, Volume: 41, Issue:19 | Piperazinyl oxazolidinone antibacterial agents containing a pyridine, diazene, or triazene heteroaromatic ring. |
| AID1609285 | Antibacterial activity against methicilline-resistant Staphylococcus aureus NRS384 USA300 after 18 to 20 hrs by CLSI-based broth microdilution assay | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Phenylthiazoles with nitrogenous side chain: An approach to overcome molecular obesity. |
| AID1504624 | Antibacterial activity against Streptococcus pyogenes ATCC 19615 by microbroth dilution method | 2017 | ACS medicinal chemistry letters, Nov-09, Volume: 8, Issue:11 | Design, Synthesis, and Antibacterial Evaluation of Oxazolidinones with Fused Heterocyclic C-Ring Substructure. |
| AID548256 | Antibacterial activity against vancomycin-susceptible Staphylococcus aureus Mu50omega expressing vraSm mutant gene after 24 hrs by Etest | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Contribution of vraSR and graSR point mutations to vancomycin resistance in vancomycin-intermediate Staphylococcus aureus. |
| AID559365 | Antimicrobial activity against compound-intermediate susceptible Coxiella burnetii isolate CP1 obtained from patient with acute Q fever infected in african green monkey Vero cells after 24 hrs by shell vial assay | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Bacteriostatic and bactericidal activities of tigecycline against Coxiella burnetii and comparison with those of six other antibiotics. |
| AID1677796 | Bacteriostatic activity against Staphylococcus aureus ATCC25923 assessed as ratio of MBC to MIC | 2020 | Bioorganic & medicinal chemistry, 11-01, Volume: 28, Issue:21 | Design, synthesis of novel 4,5-dihydroisoxazole-containing benzamide derivatives as highly potent FtsZ inhibitors capable of killing a variety of MDR Staphylococcus aureus. |
| AID528698 | Antibacterial activity against vancomycin resistant Enterococcus faecium VanA clinical isolate assessed as susceptibility level by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID67242 | In vitro antibacterial activity against Enterococcus faecalis ATCC 29212 (Efs) was determined | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | Structure-activity relationship in the oxazolidinone-quinolone hybrid series: influence of the central spacer on the antibacterial activity and the mode of action. |
| AID1862429 | Antibacterial activity against methicillin-resistant Staphylococcus aureus USA 300 (ARLG 1644) assessed as reduction in visible bacterial growth incubated for 18 to 20 hrs by CLSI based broth microdilution analysis | 2022 | European journal of medicinal chemistry, Oct-05, Volume: 240 | Membrane acting Povarov-Doebner derived compounds potently disperse preformed multidrug resistant Gram-positive bacterial biofilms. |
| AID1852696 | Inhibition of CALML3 (unknown origin) assessed as apparent protein translation inhibition constant incubated for 5 hrs by SDS gel electrophoresis | |||
| AID133991 | Protective dose of orally administered compound against intraperitoneally-induced septicaemia model ( vancomycin resistant Enterococci faecium D3HM3 strain) in murine | 2000 | Bioorganic & medicinal chemistry letters, Aug-07, Volume: 10, Issue:15 | Improved antibacterial activities of coumarin antibiotics bearing 5',5'-dialkylnoviose: biological activity of RU79115. |
| AID352925 | Antibacterial activity against Streptococcus pneumoniae C402 after 18 to 20 hrs by agar dilution method | 2009 | Bioorganic & medicinal chemistry letters, May-01, Volume: 19, Issue:9 | Synthesis and antibacterial activities of novel oxazolidinones having spiro[2,4]heptane moieties. |
| AID729224 | Antibacterial activity against methicillin-resistant Staphylococcus aureus after 16 hrs by NCCLS agar dilution method | 2013 | Journal of medicinal chemistry, Mar-28, Volume: 56, Issue:6 | Solubility-driven optimization of (pyridin-3-yl) benzoxazinyl-oxazolidinones leading to a promising antibacterial agent. |
| AID1409851 | Antibacterial activity against linezolid-resistant Staphylococcus aureus NRS271 infected in BALB/c mouse assessed as reduction of bacterial burden in liver at 0.4 mg, ip bid administered at 12 hrs prior to bacterial infection dosed at 12 intervals for 4.5 | 2018 | ACS medicinal chemistry letters, Mar-08, Volume: 9, Issue:3 | Novel Staphyloxanthin Inhibitors with Improved Potency against Multidrug Resistant |
| AID1180577 | Antimicrobial activity against 2 times drug resistance selected Staphylococcus aureus ARC2381-3F by broth microdilution/CLSI method | 2014 | Journal of medicinal chemistry, Jul-24, Volume: 57, Issue:14 | Optimization of pyrrolamide topoisomerase II inhibitors toward identification of an antibacterial clinical candidate (AZD5099). |
| AID373827 | Antimicrobial activity against panton-valentine leukocidin-negative community-acquired methicillin-resistant Staphylococcus aureus 481 after 16 passages with quinupristin-dalfopristin measured after 10 antibiotic-free subculture by multi-step resistance s | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID1327103 | Antitubercular activity against active stage Mycobacterium bovis BCG ATCC 35734 measured after 8 days by nitrate reductase assay | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Design, synthesis and biological evaluation of novel azaspiro analogs of linezolid as antibacterial and antitubercular agents. |
| AID83808 | Antibacterial activity against Haemophilus influenzae (HI1008) | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | Novel oxazolidinone-quinolone hybrid antimicrobials. |
| AID524976 | Antibacterial activity against Streptococcus sp. Group G clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Comparative surveillance study of telavancin activity against recently collected gram-positive clinical isolates from across the United States. |
| AID577142 | Volume of distribution at steady state in two-compartment pharmacokinetic/pharmacodynamic model at 200 mg, bid administered as 0.5 hr infusion over 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID1680062 | Antibacterial activity against methicillin-resistant Staphylococcus aureus clinical isolate 4 assessed as reduction in bacterial growth incubated for 16 to 20 hrs by CLSI-based broth microdilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Synthesis and antibacterial bioactivities of cationic deacetyl linezolid amphiphiles. |
| AID571927 | Ratio of MIC for Escherichia coli K-12 3-AG300 harboring acrB::rpsLneo mutant gene to MIC for Escherichia coli K-12 3-AG300 | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Site-directed mutagenesis reveals amino acid residues in the Escherichia coli RND efflux pump AcrB that confer macrolide resistance. |
| AID561091 | Antibacterial activity against Bacteroides vulgatus by CLSI M11-A7 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | In vitro activity of TR-700, the active ingredient of the antibacterial prodrug TR-701, a novel oxazolidinone antibacterial agent. |
| AID369436 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus after 20 to 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vitro activity of telavancin against gram-positive clinical isolates recently obtained in Europe. |
| AID319167 | Drug level in human lung epithelial lining fluid at 600 mg, po bid after 4 hrs | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7 | Linezolid (ZYVOX), the first member of a completely new class of antibacterial agents for treatment of serious gram-positive infections. |
| AID285004 | Antimicrobial activity against Enterococcus gallinarum at 1 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID523819 | Antimicrobial activity against oxacillin-resistant coagulase-negative Staphylococcus aureus assessed as inhibition of microbial growth at 0.5 ug/ml by CLSI method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative activities of TR-700 (torezolid) against staphylococcal blood isolates collected in Spain. |
| AID275471 | Antibacterial activity against Staphylococcus aureus | 2007 | Journal of medicinal chemistry, Jan-25, Volume: 50, Issue:2 | Isothiazoloquinolones with enhanced antistaphylococcal activities against multidrug-resistant strains: effects of structural modifications at the 6-, 7-, and 8-positions. |
| AID522015 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro antibacterial activity of CE-156811, a novel analog derived from hygromycin A. |
| AID533950 | Antimicrobial activity against hospital acquired methicillin-resistant, vancomycin resistant Staphylococcus aureus VRS1 after 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Cellular pharmacodynamics of the novel biaryloxazolidinone radezolid: studies with infected phagocytic and nonphagocytic cells, using Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Legionella pneumophila. |
| AID567453 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus CGK5 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Development of daptomycin nonsusceptibility with heterogeneous vancomycin-intermediate resistance and oxacillin susceptibility in methicillin-resistant Staphylococcus aureus during high-dose daptomycin treatment. |
| AID581013 | Antimicrobial activity against Staphylococcus epidermidis ATCC 23760 by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Mode of action of Ranbezolid against staphylococci and structural modeling studies of its interaction with ribosomes. |
| AID542716 | fT>MIC in Bacillus anthracis infected in vitro hollow fiber PK/PD model at simulated dose of 800 mg /day administered once every 24 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID535261 | Antimicrobial activity against vancomycin resistant Staphylococcus aureus VRS-9 expressing SCCmec type 2 element by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | In vitro activity of ceftaroline against community-associated methicillin-resistant, vancomycin-intermediate, vancomycin-resistant, and daptomycin-nonsusceptible Staphylococcus aureus isolates. |
| AID1744565 | Inhibition of Staphylococcus aureus FabH A81V/A111T mutant assessed as bacterial growth inhibition measured after 18 hrs by resazurin dye based broth dilution assay | 2021 | ACS medicinal chemistry letters, Mar-11, Volume: 12, Issue:3 | Semisynthesis and Biological Evaluation of Platencin Thioether Derivatives: Dual FabF and FabH Inhibitors against MRSA. |
| AID561254 | Antibacterial activity against Streptococcus pyogenes assessed as susceptible isolates by CLSI M100-S17 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | AFN-1252, a FabI inhibitor, demonstrates a Staphylococcus-specific spectrum of activity. |
| AID528697 | Antibacterial activity against vancomycin resistant Enterococcus faecium VanB clinical isolate assessed as susceptibility level by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID535013 | Antimicrobial activity against vancomycin-resistant Staphylococcus aureus by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | In vitro activity of ceftaroline against community-associated methicillin-resistant, vancomycin-intermediate, vancomycin-resistant, and daptomycin-nonsusceptible Staphylococcus aureus isolates. |
| AID284963 | Antimicrobial activity against Corynebacterium amycolatum at <= 0.06 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID590063 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus Smith infected po dosed ICR mouse assessed as protection against mouse mortality administered 1 hr after infection measured up to 7 days | 2011 | European journal of medicinal chemistry, Apr, Volume: 46, Issue:4 | Discovery of torezolid as a novel 5-hydroxymethyl-oxazolidinone antibacterial agent. |
| AID524975 | Antibacterial activity against Streptococcus sp. Group F clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Comparative surveillance study of telavancin activity against recently collected gram-positive clinical isolates from across the United States. |
| AID535259 | Antimicrobial activity against vancomycin resistant Staphylococcus aureus VRS-7 expressing SCCmec element by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | In vitro activity of ceftaroline against community-associated methicillin-resistant, vancomycin-intermediate, vancomycin-resistant, and daptomycin-nonsusceptible Staphylococcus aureus isolates. |
| AID244814 | Minimum inhibitory concentration against Enterococcus faecalis A20688 | 2005 | Bioorganic & medicinal chemistry letters, Jun-02, Volume: 15, Issue:11 | Synthesis and antibacterial activity of dihydro-1,2-oxazine and 2-pyrazoline oxazolidinones: novel analogs of linezolid. |
| AID261065 | Antibacterial activity against Moraxella catarrhalis BC-3531 | 2006 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 16, Issue:5 | Conformational constraint in oxazolidinone antibacterials. Part 2: Synthesis and structure-activity studies of oxa-, aza-, and thiabicyclo[3.1.0]hexylphenyl oxazolidinones. |
| AID756093 | Antibacterial activity against methicillin-sensitive Staphylococcus epidermidis assessed as growth inhibition after 16 hrs by agar dilution method | 2013 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 23, Issue:13 | Synthesis and biological evaluation of novel benzoxazinyl-oxazolidinones as potential antibacterial agents. |
| AID387456 | Antibacterial activity against beta-lactamase deficient Haemophilus influenzae DRCC 433 | 2008 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 18, Issue:18 | Novel and potent oxazolidinone antibacterials featuring 3-indolylglyoxamide substituents. |
| AID1578429 | Antimicrobial activity against vancomycin-resistant Enterococcus faecalis ATCC 51299 by broth liquid microdilution method | 2020 | European journal of medicinal chemistry, Jan-01, Volume: 185 | Modifying the lipophilic part of phenylthiazole antibiotics to control their drug-likeness. |
| AID1609265 | Antibacterial activity against methicillin-resistant Streptococcus pneumoniae ATCC 700677 after 18 to 20 hrs by CLSI-based broth microdilution assay | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Phenylthiazoles with nitrogenous side chain: An approach to overcome molecular obesity. |
| AID542896 | fAUC (24 hrs) in Bacillus anthracis infected in vitro hollow fiber PK/PD model at simulated dose of 600 mg administered every 12 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID188644 | In vivo activity against Staphylococcus aureus when administered orally for 1 hr in rat at a dose of 15 mg/kg | 2003 | Bioorganic & medicinal chemistry letters, Jul-07, Volume: 13, Issue:13 | Synthesis and in vitro activity of new methylenepiperidinyl and methylenepyrrolidinyl oxazolidinone antibacterial agents. |
| AID262227 | Antibacterial activity against Staphylococcus epidermidis ATCC 155 | 2006 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 16, Issue:6 | Novel 4-N-substituted aryl pent-2-ene-1,4-dione derivatives of piperazinyloxazolidinones as antibacterials. |
| AID519094 | Antimicrobial activity against Staphylococcus aureus NRS120 clinical isolate harboring G2576U mutation in 23S rRNA by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Linezolid and tiamulin cross-resistance in Staphylococcus aureus mediated by point mutations in the peptidyl transferase center. |
| AID583896 | Antibacterial activity against vancomycin-intermediate Staphylococcus aureus isolate 454 (NRS404) by broth microdilution assay | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Comparative efficacies of human simulated exposures of telavancin and vancomycin against methicillin-resistant Staphylococcus aureus with a range of vancomycin MICs in a murine pneumonia model. |
| AID303966 | Bacteriostatic activity against Staphylococcus after 48 hrs by time kill study | 2007 | Journal of medicinal chemistry, Nov-29, Volume: 50, Issue:24 | Antibacterial oxazolidinones possessing a novel C-5 side chain. (5R)-trans-3-[3-Fluoro-4- (1-oxotetrahydrothiopyran-4-yl)phenyl]-2- oxooxazolidine-5-carboxylic acid amide (PF-00422602), a new lead compound. |
| AID1676982 | Antimicrobial activity against Escherichia coli BW25113 harboring TolC mutant assessed as reduction in microbial growth after 48 hrs by CLSI based broth microdilution method | |||
| AID285110 | Antimicrobial activity against viridans group Streptococcus mutans at 1 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID1594367 | Antibacterial activity against Acinetobacter baumannii BAA1605 after 18 to 24 hrs by broth microdilution assay | 2019 | Bioorganic & medicinal chemistry, 05-01, Volume: 27, Issue:9 | Second-generation aryl isonitrile compounds targeting multidrug-resistant Staphylococcus aureus. |
| AID562624 | Antimicrobial activity against Group A Streptococcus by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | In vitro activities of three new dihydrofolate reductase inhibitors against clinical isolates of gram-positive bacteria. |
| AID1180579 | Antimicrobial activity against 2 times drug resistance selected Staphylococcus aureus ARC2398-1F by broth microdilution/CLSI method | 2014 | Journal of medicinal chemistry, Jul-24, Volume: 57, Issue:14 | Optimization of pyrrolamide topoisomerase II inhibitors toward identification of an antibacterial clinical candidate (AZD5099). |
| AID671569 | Antibacterial activity against Streptococcus pneumoniae SPN160 infected in neutropenic Balb/c mouse infection model assessed as reduction in lung CFU at 30 mg/kg, po administered 2 and 12 hrs post infection measured 24 hrs post treatment | 2012 | Journal of medicinal chemistry, Jan-26, Volume: 55, Issue:2 | Fluorocyclines. 2. Optimization of the C-9 side-chain for antibacterial activity and oral efficacy. |
| AID1243931 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus NRS119 assessed as reduction in bacterial growth incubated for 18 to 20 hrs at 37 degC by broth microdilution method | 2015 | European journal of medicinal chemistry, Aug-28, Volume: 101 | Discovery and characterization of aryl isonitriles as a new class of compounds versus methicillin- and vancomycin-resistant Staphylococcus aureus. |
| AID131687 | Effective dose of compound after oral administration in murine model infected with Staphylococcus aureus OC4172 (Smith) was determined | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | Synthesis and antibacterial activity of pyrroloaryl-substituted oxazolidinones. |
| AID523829 | Antimicrobial activity against linezolid-resistant coagulase-negative Staphylococcus assessed as inhibition of microbial growth at 32 ug/ml by CLSI method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative activities of TR-700 (torezolid) against staphylococcal blood isolates collected in Spain. |
| AID564809 | Bactericidal activity against methicillin-resistant coagulase-negative Staphylococcus haemolyticus after 24 hrs by plate counting method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID283621 | Antimicrobial activity against Enterococcus faecium 2 L1 with heterozygous 23S rRNA G2576U mutation | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | In vitro activity of the oxazolidinone RWJ-416457 against linezolid-resistant and -susceptible staphylococci and enterococci. |
| AID1611132 | Aqueous solubility of compound | 2019 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 29, Issue:23 | Design and synthesis of biaryloxazolidinone derivatives containing amide or acrylamide moiety as novel antibacterial agents against Gram-positive bacteria. |
| AID1400042 | Antibacterial activity against Staphylococcus aureus BAA 1683 incubated for 24 hrs under aerobic condition by MABA | 2018 | Bioorganic & medicinal chemistry, 09-15, Volume: 26, Issue:17 | An antimycobacterial pleuromutilin analogue effective against dormant bacilli. |
| AID285044 | Antimicrobial activity against Enterococcus avium by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID285383 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 using in vitro PK/PD model with 120 mg/24 hr continuous infusion simulated regimen after 72 hrs | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Pharmacokinetic/pharmacodynamic factors influencing emergence of resistance to linezolid in an in vitro model. |
| AID1853457 | Bactericidal activity against Staphylococcus aureus ATCC 25923 assessed as reduction in colony forming unit incubated for 20 hrs | 2021 | RSC medicinal chemistry, Nov-17, Volume: 12, Issue:11 | SF |
| AID571999 | Antibacterial activity against Streptococcus constellatus by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID1609290 | Antibacterial activity against Staphylococcus aureus ATCC BAA42 after 18 to 20 hrs by CLSI-based broth microdilution assay | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Phenylthiazoles with nitrogenous side chain: An approach to overcome molecular obesity. |
| AID1168001 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis clinical isolate 5648 after overnight incubation by two-fold serial dilution method | 2014 | Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21 | Synthesis and biological evaluation of novel peptide BF2 as an antibacterial agent against clinical isolates of vancomycin-resistant enterococci. |
| AID541057 | Ratio of Cmax to MIC for methicillin-resistant Staphylococcus aureus ATCC 43300 in Albino guiena pig model of foreign-body infection at 50 mg/kg, ip | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Linezolid alone or combined with rifampin against methicillin-resistant Staphylococcus aureus in experimental foreign-body infection. |
| AID584995 | Antibacterial activity against pSCFS7-deficient methicillin-resistant Staphylococcus aureus M05/0060-C1 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Identification and characterization of the multidrug resistance gene cfr in a Panton-Valentine leukocidin-positive sequence type 8 methicillin-resistant Staphylococcus aureus IVa (USA300) isolate. |
| AID1168024 | Antibacterial activity against vancomycin-resistant Enterococcus faecium clinical isolate 12/266 after overnight incubation by two-fold serial dilution method | 2014 | Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21 | Synthesis and biological evaluation of novel peptide BF2 as an antibacterial agent against clinical isolates of vancomycin-resistant enterococci. |
| AID308921 | Antibacterial activity against Staphylococcus aureus ATCC 25923 by broth microdilution method | 2007 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 17, Issue:18 | Synthesis and in vitro antibacterial activity of novel methylamino piperidinyl oxazolidinones. |
| AID573385 | Antibacterial activity against beta lactamase-positive Moraxella catarrhalis by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID1151711 | Antibacterial activity against methicillin-resistant Staphylococcus aureus by broth microdilution method | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID574086 | Ratio of fAUC (24 hrs) for penicillin-susceptible Streptococcus pneumoniae ATCC 6301 infected iv dosed mouse to MIC for penicillin-susceptible Streptococcus pneumoniae ATCC 6301 | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | In vivo activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. |
| AID561514 | Antibacterial activity against Enterococcus faecalis by CLSI broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Potency and bactericidal activity of iclaprim against recent clinical gram-positive isolates. |
| AID383571 | Tmax in Sprague-Dawley rat at 10 mg/kg, iv | 2008 | European journal of medicinal chemistry, Apr, Volume: 43, Issue:4 | Synthesis and in vitro antibacterial activities of novel oxazolidinones. |
| AID1721014 | Antitubercular activity against Mycobacterium tuberculosis H37Rv incubated for 7 days by microplate alamar blue assay | 2020 | Journal of medicinal chemistry, 09-10, Volume: 63, Issue:17 | Discovery of a Conformationally Constrained Oxazolidinone with Improved Safety and Efficacy Profiles for the Treatment of Multidrug-Resistant Tuberculosis. |
| AID584115 | Antibacterial activity against Escherichia coli KAM32 harboring pSP72 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | LmrS is a multidrug efflux pump of the major facilitator superfamily from Staphylococcus aureus. |
| AID326295 | Antibacterial activity against methicillin-resistant Staphylococcus aureus 859 at 4 hrs daily exposure for 5 days by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Comparative activities of daptomycin, linezolid, and tigecycline against catheter-related methicillin-resistant Staphylococcus bacteremic isolates embedded in biofilm. |
| AID573890 | fAUC (0 to 24 hrs) in CF-1 mouse at 2 mg/kg, iv | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | In vivo activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. |
| AID560822 | Ratio of Cmax in human adults with pulmonary tuberculosis at 600 mg administered once daily for 5 days to MIC for Mycobacterium tuberculosis | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Population pharmacokinetics of linezolid in adults with pulmonary tuberculosis. |
| AID562171 | Antimicrobial activity against heterogeneous vancomycin-intermediate Staphylococcus aureus 873 after 50 passages by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID562389 | Antimicrobial activity against Enterococcus faecalis clinical isolates assessed as percent susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID1451768 | Antibacterial activity against Staphylococcus aureus Mu50 infected in BALB/c mouse assessed as reduction of bacterial burden in liver at 0.4 mg, ip bid for 4.5 days administered 6 hrs post bacterial infection measured 108 hrs post infection relative to co | 2017 | Journal of medicinal chemistry, 10-12, Volume: 60, Issue:19 | Novel Inhibitors of Staphyloxanthin Virulence Factor in Comparison with Linezolid and Vancomycin versus Methicillin-Resistant, Linezolid-Resistant, and Vancomycin-Intermediate Staphylococcus aureus Infections in Vivo. |
| AID561074 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus by CLSI M7-A7 broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | In vitro activity of TR-700, the active ingredient of the antibacterial prodrug TR-701, a novel oxazolidinone antibacterial agent. |
| AID524689 | Antibacterial activity against penicillin-susceptible Streptococcus pneumoniae clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro antibacterial activity of CE-156811, a novel analog derived from hygromycin A. |
| AID1205590 | Fraction unbound (%) in human plasma at 10 uM by LC/MS-MS analysis | 2015 | Journal of medicinal chemistry, Apr-09, Volume: 58, Issue:7 | X-ray crystal structures of Escherichia coli RNA polymerase with switch region binding inhibitors enable rational design of squaramides with an improved fraction unbound to human plasma protein. |
| AID1271212 | Metabolic stability in human liver microsomes after 30 mins by LC-MS/MS analysis | 2015 | ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11 | Design, Synthesis, and Identification of Silicon Incorporated Oxazolidinone Antibiotics with Improved Brain Exposure. |
| AID561083 | Antibacterial activity against penicillin-susceptible Streptococcus pneumoniae by CLSI M7-A7 broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | In vitro activity of TR-700, the active ingredient of the antibacterial prodrug TR-701, a novel oxazolidinone antibacterial agent. |
| AID776672 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus ATCC 29213 after 16 to 20 hrs by microdilution method | 2013 | European journal of medicinal chemistry, Nov, Volume: 69 | Novel promising linezolid analogues: rational design, synthesis and biological evaluation. |
| AID763954 | Antibacterial activity against Moraxella catarrhalis clinical isolate 36 after 18 hrs by NCCLS agar dilution method | 2013 | European journal of medicinal chemistry, Aug, Volume: 66 | Synthesis and antibacterial activities of N-substituted-glycinyl 1H-1,2,3-triazolyl oxazolidinones. |
| AID1553374 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 29213 measured after 16 hrs by broth microdilution method | 2019 | Bioorganic & medicinal chemistry letters, 09-15, Volume: 29, Issue:18 | Incorporation of a chiral gem-disubstituted nitrogen heterocycle yields an oxazolidinone antibiotic with reduced mitochondrial toxicity. |
| AID370022 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus Smith infected in C3H mouse assessed as eradication at 3.12 mg/kg/day, iv administered within 15 mins of infection assessed per gram of kidney measured after 48 hrs by organ burd | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vivo efficacy of a novel oxazolidinone compound in two mouse models of infection. |
| AID374588 | Antimicrobial activity against Staphylococcus aureus MTCC 3160 after 24 hrs by agar dilution assay | 2009 | European journal of medicinal chemistry, Apr, Volume: 44, Issue:4 | Synthesis and antibacterial activity of some new 2,3-dimethoxy-3-hydroxy-2-(1-phenyl-3-aryl-4-pyrazolyl)chromanones. |
| AID576660 | Bactericidal activity against 12 hrs peripheral compartment culture samples of Enterococcus faecalis ATCC 29212 in two-compartment pharmacokinetic/pharmacodynamic model assessed as effect on bacterial count at 600 mg, bid administered as 0.5 hr infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID1161215 | Antimicrobial activity against Staphylococcus aureus ATCC 33591 in septicemia mouse model administered intragastrically measured after 14 days | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | Synthesis, antibacterial activity, and biological evaluation of formyl hydroxyamino derivatives as novel potent peptide deformylase inhibitors against drug-resistant bacteria. |
| AID522896 | Antibacterial activity against vancomycin-intermediate Staphylococcus aureus isolate 1013 after 24 hrs by modified broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Antistaphylococcal activity of ACHN-490 tested alone and in combination with other agents by time-kill assay. |
| AID1415068 | Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate 4 after 16 hrs by agar dilution method | 2018 | Journal of medicinal chemistry, 12-27, Volume: 61, Issue:24 | Semisynthesis of Platensimycin Derivatives with Antibiotic Activities in Mice via Suzuki-Miyaura Cross-Coupling Reactions. |
| AID522906 | Antibacterial activity against vancomycin-intermediate Staphylococcus aureus isolate 1984 after 24 hrs by modified broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Antistaphylococcal activity of ACHN-490 tested alone and in combination with other agents by time-kill assay. |
| AID1907628 | Antibacterial activity against Staphylococcus aureus ATCC6538 incubated for 18 to 20 hrs by double dilution method | 2022 | European journal of medicinal chemistry, Jun-05, Volume: 236 | Novel benzothiazole‒urea hybrids: Design, synthesis and biological activity as potent anti-bacterial agents against MRSA. |
| AID210360 | In vitro antibacterial activity against penicillin sensitive Streptococcus pneumoniae UC 9912; range is 0.5-1 | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | The synthesis and antibacterial activity of 1,3,4-thiadiazole phenyl oxazolidinone analogues. |
| AID577108 | AUBC (0 to 24 hrs) in Enterococcus faecalis Ef1497 MutM3 in two-compartment pharmacokinetic/pharmacodynamic model at 200 mg, bid administered as 0.5 hr infusion for 2 days | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID1361107 | Bactericidal activity against methicillin-resistant Staphylococcus aureus USA400 NRS123 clinical isolate preincubated for 20 hrs followed by TSA plating and measured after 18 hrs | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | N-(1,3,4-oxadiazol-2-yl)benzamide analogs, bacteriostatic agents against methicillin- and vancomycin-resistant bacteria. |
| AID522884 | Antibacterial activity against vancomycin-resistant Staphylococcus aureus isolate 1263 after 24 hrs by modified broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Antistaphylococcal activity of ACHN-490 tested alone and in combination with other agents by time-kill assay. |
| AID558482 | Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus 1287 measured on day 10 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID545806 | Antimicrobial activity against vancomycin-resistant Staphylococcus aureus isolate VRS5 planktonic cells by broth microdilution method in presence of 0.002% polysorbate 80 | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Oritavancin kills stationary-phase and biofilm Staphylococcus aureus cells in vitro. |
| AID687497 | Clearance in rat | 2012 | Bioorganic & medicinal chemistry, Oct-15, Volume: 20, Issue:20 | Antitubercular nitrofuran isoxazolines with improved pharmacokinetic properties. |
| AID373315 | Antibacterial activity against Escherichia coli ATCC 25922 after 18 hrs by NCCLS M7-A4 method | 2009 | European journal of medicinal chemistry, Mar, Volume: 44, Issue:3 | Synthesis, antibacterial and anticonvulsant evaluations of some cyclic enaminones. |
| AID1710570 | Antibacterial activity against Staphylococcus aureus ATCC 25923 assessed as inhibition of visible bacterial growth incubated for 18 to 20 hrs by CLSI method | 2020 | RSC medicinal chemistry, Jan-01, Volume: 11, Issue:1 | Potent trifluoromethoxy, trifluoromethylsulfonyl, trifluoromethylthio and pentafluorosulfanyl containing (1,3,4-oxadiazol-2-yl)benzamides against drug-resistant Gram-positive bacteria. |
| AID1873944 | Antibacterial activity against Staphylococcus aureus ATCC 29213 at pH 8.6 incubated for 16 to 20 hrs in absence of foetal bovine serum by broth microdilution method | 2022 | European journal of medicinal chemistry, Aug-05, Volume: 238 | Design, synthesis and activity against drug-resistant bacteria evaluation of C-20, C-23 modified 5-O-mycaminosyltylonolide derivatives. |
| AID244852 | Minimum inhibitory concentration against Enterococcus faecium ATCC 6569 | 2004 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 14, Issue:22 | Aryl urea analogs with broad-spectrum antibacterial activity. |
| AID576891 | Ratio of Cmax to MIC for 12.5 hrs peripheral compartment culture samples of Enterococcus faecalis Ef1497 in two-compartment pharmacokinetic/pharmacodynamic model at 600 mg, bid administered as 0.5 hr infusion for 2 days | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID541056 | Ratio of Cmax to MIC for methicillin-resistant Staphylococcus aureus ATCC 43300 in Albino guiena pig model of foreign-body infection at 75 mg/kg, ip | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Linezolid alone or combined with rifampin against methicillin-resistant Staphylococcus aureus in experimental foreign-body infection. |
| AID535015 | Antimicrobial activity against vancomycin-resistant Staphylococcus aureus assessed as susceptible isolates by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | In vitro activity of ceftaroline against community-associated methicillin-resistant, vancomycin-intermediate, vancomycin-resistant, and daptomycin-nonsusceptible Staphylococcus aureus isolates. |
| AID10637 | In vivo activity against Staphylococcus aureus when administered orally for 1 hr in rat at a dose of 15 mg/kg | 2003 | Bioorganic & medicinal chemistry letters, Jul-07, Volume: 13, Issue:13 | Synthesis and in vitro activity of new methylenepiperidinyl and methylenepyrrolidinyl oxazolidinone antibacterial agents. |
| AID1233135 | Antibacterial activity against patient-derived methicillin-resistant Staphylococcus aureus 7419 after 18 to 20 hrs by microbroth dilution method | 2015 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 25, Issue:13 | Thiol activated prodrugs of sulfur dioxide (SO2) as MRSA inhibitors. |
| AID576326 | Antibacterial activity against 10'4 to 10'5 CFU methicillin-susceptible Staphylococcus aureus after 18 hrs by CLSI 2-fold agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | In vitro and in vivo activities of LCB01-0371, a new oxazolidinone. |
| AID206816 | In vitro antibacterial activity against Staphylococcus pyogenes ATTCC8668 | 2003 | Bioorganic & medicinal chemistry letters, Jul-07, Volume: 13, Issue:13 | Synthesis and in vitro activity of new methylenepiperidinyl and methylenepyrrolidinyl oxazolidinone antibacterial agents. |
| AID285369 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Pharmacokinetic/pharmacodynamic factors influencing emergence of resistance to linezolid in an in vitro model. |
| AID1126486 | Antimicrobial activity against Staphylococcus aureus Oxford | 2014 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 24, Issue:8 | Synthesis, antibiotic activity and structure-activity relationship study of some 3-enaminetetramic acids. |
| AID424764 | Antibacterial activity against vancomycin-sensitive Enterococcus faecalis CL8516 after 20 hrs by twofold serial broth dilution method | 2009 | Journal of natural products, May-22, Volume: 72, Issue:5 | Thiazomycins, thiazolyl peptide antibiotics from Amycolatopsis fastidiosa. |
| AID533976 | Antimicrobial activity against linezolid-susceptible Staphylococcus aureus NRS384 infected in THP1 cells after 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Cellular pharmacodynamics of the novel biaryloxazolidinone radezolid: studies with infected phagocytic and nonphagocytic cells, using Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Legionella pneumophila. |
| AID576895 | Ratio of Cmax to MIC for 12.5 hrs peripheral compartment culture samples of Enterococcus faecalis Ef1497 MutM3 in two-compartment pharmacokinetic/pharmacodynamic model at 200 mg, bid administered as 0.5 hr infusion for 2 days | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID369448 | Antimicrobial activity against Streptococcus viridans after 20 to 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vitro activity of telavancin against gram-positive clinical isolates recently obtained in Europe. |
| AID533412 | Antimicrobial activity against Finegoldia magna assessed as resistant isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activities of doripenem, a new broad-spectrum carbapenem, against recently collected clinical anaerobic isolates, with emphasis on the Bacteroides fragilis group. |
| AID442577 | Antibacterial activity against Klebsiella pneumoniae ATCC 27736 after 24 hrs by spectrophotometry | 2010 | European journal of medicinal chemistry, Feb, Volume: 45, Issue:2 | Synthesis of nitroimidazole derived oxazolidinones as antibacterial agents. |
| AID542385 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus ST398 expressing cfr, fexA, erm(A), tet(M) and mecA genes | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Methicillin-resistant and -susceptible Staphylococcus aureus strains of clonal lineages ST398 and ST9 from swine carry the multidrug resistance gene cfr. |
| AID558497 | Antimicrobial activity against vancomycin-resistant Staphylococcus aureus 510 measured on day 15 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID284945 | Antimicrobial activity against Bacillus spp. at <= 0.06 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID311482 | Antimicrobial activity against vancomycin-resistant Enterococcus faecalis ATCC 29212 after 14 to 16 hrs by serial microbroth dilution method | 2007 | Journal of natural products, Sep, Volume: 70, Issue:9 | Lipoxazolidinones A, B, and C: antibacterial 4-oxazolidinones from a marine actinomycete isolated from a Guam marine sediment. |
| AID528730 | Antibacterial activity against penicillin resistant Streptococcus pneumoniae clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID1308238 | Antibacterial activity against methicillin-resistant Staphylococcus aureus NRS70 incubated for 16 to 20 hrs by microdilution method | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10 | Structure-Activity Relationship for the 4(3H)-Quinazolinone Antibacterials. |
| AID567490 | Antimicrobial activity against linezolid pretreated vancomycin-intermediate Staphylococcus aureus isolate 5 obtained from wound of patient by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Clinical outcomes by methicillin-resistant Staphylococcus aureus staphylococcal cassette chromosome mec type: isolates recovered from a phase IV clinical trial of linezolid and vancomycin for complicated skin and skin structure infections. |
| AID1472758 | In vivo anti-virulence activity against methicillin-resistant Staphylococcus aureus LRSA202 infected in BALB/c mouse model assessed as reduction in bacterial load in heart at 0.1 mg bid for 3.5 days administered intraperitoneally 6 hrs post infection by s | 2018 | Journal of medicinal chemistry, 01-11, Volume: 61, Issue:1 | Novel Terminal Bipheny-Based Diapophytoene Desaturases (CrtN) Inhibitors as Anti-MRSA/VISR/LRSA Agents with Reduced hERG Activity. |
| AID572002 | Antibacterial activity against Parabacteroides merdae by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID1574839 | Antibacterial activity against vancomycin-resistant Enterococcus faecium by broth liquid microdilution method | 2019 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 29, Issue:3 | Design and synthesis of biaryloxazolidinone derivatives containing a rhodanine or thiohydantoin moiety as novel antibacterial agents against Gram-positive bacteria. |
| AID284987 | Antimicrobial activity against Enterococcus casseliflavus at <= 0.06 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID285047 | Antimicrobial activity against Enterococcus gallinarum by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID1151742 | Antibacterial activity against Staphylococcus aureus measured after 4 serial passages | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID531642 | Antimicrobial activity against linezolid-resistant Enterococcus faecalis P5 | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | R chi-01, a new family of oxazolidinones that overcome ribosome-based linezolid resistance. |
| AID562383 | Antimicrobial activity against vancomycin-susceptible Enterococcus faecium clinical isolates assessed as percent susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID444053 | Renal clearance in human | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3 | Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. |
| AID1079935 | Cytolytic liver toxicity, either proven histopathologically or where the ratio of maximal ALT or AST activity above normal to that of Alkaline Phosphatase is > 5 (see ACUTE). Value is number of references indexed. [column 'CYTOL' in source] | |||
| AID348600 | Antibacterial activity against Streptococcus agalactiae ATCC 2901 after 18 to 20 hrs by agar dilution method | 2008 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 18, Issue:21 | Synthesis and antibacterial activities of novel oxazolidinones having cyclic sulfonamide moieties. |
| AID582992 | Antimicrobial activity against rifampin-, fusidic acid-resistant Enterococcus faecium BM-4105 by Etest | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | vanM, a new glycopeptide resistance gene cluster found in Enterococcus faecium. |
| AID428282 | Antituberculosis activity against linezolid-resistant Mycobacterium smegmatis without mutation in 23S rRNA | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro-selected linezolid-resistant Mycobacterium tuberculosis mutants. |
| AID560512 | Antimicrobial activity against SCCmec type III vancomycin-intermediate Staphylococcus aureus isolate b6k1642 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID1832944 | Antibacterial activity against Vanomycin-resistant Enterococcus faecalis NCTC 12201 assessed as reduction in bacterial growth incubated for 20 hrs by microplate reader method | 2021 | Bioorganic & medicinal chemistry, 11-01, Volume: 49 | Synthesis, microbiological evaluation and structure activity relationship analysis of linezolid analogues with different C5-acylamino substituents. |
| AID285127 | Antimicrobial activity against viridans group Streptococcus salivarius at 0.5 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID284996 | Antimicrobial activity against Enterococcus durans at 0.25 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID345136 | Antimicrobial activity against Streptococcus pyogenes Msr 610 expressing erm(B) gene by NCCLS method | 2008 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 18, Issue:23 | Design at the atomic level: generation of novel hybrid biaryloxazolidinones as promising new antibiotics. |
| AID1265126 | Reversible inhibition of human MAO-A | 2015 | European journal of medicinal chemistry, Dec-01, Volume: 106 | Synthesis and biological evaluation of novel 5-(hydroxamic acid)methyl oxazolidinone derivatives. |
| AID1862419 | Antibacterial activity against Staphylococcus aureus ATCC 25923 assessed as reduction in visible bacterial growth incubated for 18 to 20 hrs by CLSI based broth microdilution analysis | 2022 | European journal of medicinal chemistry, Oct-05, Volume: 240 | Membrane acting Povarov-Doebner derived compounds potently disperse preformed multidrug resistant Gram-positive bacterial biofilms. |
| AID244813 | Minimum inhibitory concentration against Enterococcus faecium A24885 | 2005 | Bioorganic & medicinal chemistry letters, Jun-02, Volume: 15, Issue:11 | Synthesis and antibacterial activity of dihydro-1,2-oxazine and 2-pyrazoline oxazolidinones: novel analogs of linezolid. |
| AID1151726 | Antibacterial activity against Streptococcus pyogenes | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID270150 | Antibacterial activity against gram positive methicillin-susceptible Staphylococcus aureus Smith OC 4172 by broth microdilution assay | 2006 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 16, Issue:17 | Antibacterial activity of pyrrolopyridine-substituted oxazolidinones: synthesis and in vitro SAR of various C-5 acetamide replacements. |
| AID565743 | Antimicrobial activity against Enterococcus faecium expressing VanB gene clinical isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID604289 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 1094 after 16 to 24 hrs by twofold serial dilution method | 2011 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 21, Issue:14 | 7-Alkyl-N(2)-substituted-3-deazaguanines. Synthesis, DNA polymerase III inhibition and antibacterial activity. |
| AID285381 | Bactericidal activity against vancomycin-intermediate Staphylococcus aureus Mu50 assessed as reduction of CFU using in vitro PK/PD model with 120 mg/24 hr continuous infusion simulated regimen after 48 hrs | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Pharmacokinetic/pharmacodynamic factors influencing emergence of resistance to linezolid in an in vitro model. |
| AID581656 | Antibacterial activity against revertant Staphylococcus aureus at pH 7.4 after 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Intracellular activity of antibiotics in a model of human THP-1 macrophages infected by a Staphylococcus aureus small-colony variant strain isolated from a cystic fibrosis patient: pharmacodynamic evaluation and comparison with isogenic normal-phenotype a |
| AID625283 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for elevated liver function tests | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID1409841 | Antibacterial activity against Staphylococcus aureus Newman infected in BALB/c mouse assessed as reduction of bacterial burden in heart at 0.4 mg, ip bid administered at 12 hrs prior to bacterial infection dosed at 12 intervals for 4.5 days relative to co | 2018 | ACS medicinal chemistry letters, Mar-08, Volume: 9, Issue:3 | Novel Staphyloxanthin Inhibitors with Improved Potency against Multidrug Resistant |
| AID293550 | Antibacterial activity against Staphylococcus aureus MTCC 3160 after 24 hrs by agar dilution assay | 2007 | European journal of medicinal chemistry, Jun, Volume: 42, Issue:6 | Organoiodine(III) mediated synthesis of 3,9-diaryl- and 3,9-difuryl-bis-1,2,4-triazolo[4,3-a][4,3-c]pyrimidines as antibacterial agents. |
| AID285388 | Area under population analysis profile for vancomycin-resistant Enterococcus faecium ATCC 700221 using in vitro PK/PD model relative to growth control with 120 mg/24 hrs continuous infusion regimen after 72 hrs | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Pharmacokinetic/pharmacodynamic factors influencing emergence of resistance to linezolid in an in vitro model. |
| AID388044 | Antibacterial activity against methicillin-resistant Staphylococcus aureus MB5393 containing COL plasmid after 18 to 20 hrs by serial dilution method | 2008 | Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19 | Isolation, structure, and antibacterial activity of thiazomycin A, a potent thiazolyl peptide antibiotic from Amycolatopsis fastidiosa. |
| AID1472764 | In vivo anti-virulence activity against Staphylococcus aureus NRS271 infected in BALB/c mouse model assessed as reduction in bacterial load in kidney at 0.4 mg bid for 4.5 days administered orally 6 hrs post infection by serial dilution method relative to | 2018 | Journal of medicinal chemistry, 01-11, Volume: 61, Issue:1 | Novel Terminal Bipheny-Based Diapophytoene Desaturases (CrtN) Inhibitors as Anti-MRSA/VISR/LRSA Agents with Reduced hERG Activity. |
| AID373316 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after 18 hrs by NCCLS M7-A4 method | 2009 | European journal of medicinal chemistry, Mar, Volume: 44, Issue:3 | Synthesis, antibacterial and anticonvulsant evaluations of some cyclic enaminones. |
| AID531576 | Antibacterial activity against Gemella morbillorum obtained from complicated skin and skin structure infections by RapID ANA system | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID1400040 | Antibacterial activity against Staphylococcus aureus BAA 2094 incubated for 24 hrs under aerobic condition by MABA | 2018 | Bioorganic & medicinal chemistry, 09-15, Volume: 26, Issue:17 | An antimycobacterial pleuromutilin analogue effective against dormant bacilli. |
| AID522900 | Antibacterial activity against vancomycin-intermediate Staphylococcus aureus isolate 1017 after 24 hrs by modified broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Antistaphylococcal activity of ACHN-490 tested alone and in combination with other agents by time-kill assay. |
| AID1744555 | Antibacterial activity against Enterococcus faecalis ATCC 29212 assessed as inhibition of bacterial growth measured after 16 hrs by agar plate dilution method | 2021 | ACS medicinal chemistry letters, Mar-11, Volume: 12, Issue:3 | Semisynthesis and Biological Evaluation of Platencin Thioether Derivatives: Dual FabF and FabH Inhibitors against MRSA. |
| AID206993 | The compound was evaluated for its anti-bacterial activity against methicillin resistant Staphylococcus epidermidis | 1998 | Journal of medicinal chemistry, Dec-17, Volume: 41, Issue:26 | Nitrogen-carbon-linked (azolylphenyl)oxazolidinones with potent antibacterial activity against the fastidious gram-negative organisms Haemophilus influenzae and Moraxella catarrhalis. |
| AID1596560 | Bactericidal activity against Staphylococcus aureus ATCC 6538 assessed as reduction in bacterial cell growth incubated for 18 to 20 hrs followed by re-plating on tryptic soy agar plates at 37 degC for 18 hrs by broth microdilution assay | 2019 | European journal of medicinal chemistry, Aug-01, Volume: 175 | Lipophilic efficient phenylthiazoles with potent undecaprenyl pyrophosphatase inhibitory activity. |
| AID524973 | Antibacterial activity against Streptococcus agalactiae clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Comparative surveillance study of telavancin activity against recently collected gram-positive clinical isolates from across the United States. |
| AID577135 | AUC in two-compartment pharmacokinetic/pharmacodynamic model at 800 mg, bid administered as 0.5 hr infusion over 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID1451771 | Antibacterial activity against Staphylococcus aureus NRS271 infected in BALB/c mouse assessed as reduction of bacterial burden in heart at 0.4 mg, ip bid for 4.5 days administered 6 hrs post bacterial infection measured 108 hrs post infection relative to | 2017 | Journal of medicinal chemistry, 10-12, Volume: 60, Issue:19 | Novel Inhibitors of Staphyloxanthin Virulence Factor in Comparison with Linezolid and Vancomycin versus Methicillin-Resistant, Linezolid-Resistant, and Vancomycin-Intermediate Staphylococcus aureus Infections in Vivo. |
| AID573117 | Antibacterial activity against methicillin-resistant Staphylococcus aureus assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID565486 | Bactericidal activity against methicillin-resistant Staphylococcus aureus after 24 hrs by M26-A method in presence of 50% human plasma | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro bactericidal activity of iclaprim in human plasma. |
| AID207216 | In vitro minimum inhibitory concentration against Staphylococcus aureus Oxford | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | New classes of antibacterial oxazolidinones with C-5, methylene O-linked heterocyclic side chains. |
| AID585159 | Antibacterial activity against Mycobacterium smegmatis harboring 23S rRNA A2453U mutant after 24 generation times | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Mutations in 23S rRNA at the peptidyl transferase center and their relationship to linezolid binding and cross-resistance. |
| AID565491 | Ratio of MBC to MIC for methicillin-susceptible Staphylococcus aureus in presence of 50% human plasma | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro bactericidal activity of iclaprim in human plasma. |
| AID1446758 | Antibacterial activity against methicillin-resistant Staphylococcus aureus USA300 NRS384 clinical isolate after 20 hrs by broth microdilution method | 2017 | European journal of medicinal chemistry, Apr-21, Volume: 130 | Diphenylurea derivatives for combating methicillin- and vancomycin-resistant Staphylococcus aureus. |
| AID561238 | Antibacterial activity against methicillin-resistant Staphylococcus aureus assessed as susceptible isolates by CLSI M100-S17 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | AFN-1252, a FabI inhibitor, demonstrates a Staphylococcus-specific spectrum of activity. |
| AID560824 | Ratio of AUC (0 to 24 hrs) in human adults with pulmonary tuberculosis at 600 mg administered once daily for 5 days to MIC for Mycobacterium tuberculosis | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Population pharmacokinetics of linezolid in adults with pulmonary tuberculosis. |
| AID260742 | Antibacterial activity against Enterococcus faecium 19434 | 2006 | Journal of medicinal chemistry, Feb-23, Volume: 49, Issue:4 | Hybrid antibacterials. DNA polymerase-topoisomerase inhibitors. |
| AID285321 | Antimicrobial activity against Nocardia asteroides by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Daptomycin susceptibility of unusual gram-positive bacteria: comparison of results obtained by the Etest and the broth microdilution method. |
| AID424770 | Antibacterial activity against Streptococcus pyogenes CL10440 after 20 hrs by twofold serial broth dilution method | 2009 | Journal of natural products, May-22, Volume: 72, Issue:5 | Thiazomycins, thiazolyl peptide antibiotics from Amycolatopsis fastidiosa. |
| AID571808 | Antibacterial activity against Clostridium scindens by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID370027 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus Smith infected in po dosed C3H mouse localized infection model assessed as reduction of number of CFU per gram of kidney administered 15 mins after infection measured after 48 hr | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vivo efficacy of a novel oxazolidinone compound in two mouse models of infection. |
| AID263962 | Antibacterial activity against methicillin-resistant Staphylococcus aureus DRCC 446 | 2006 | Bioorganic & medicinal chemistry letters, May-01, Volume: 16, Issue:9 | Synthesis and antibacterial activity of novel oxazolidinones bearing N-hydroxyacetamidine substituent. |
| AID285382 | Bactericidal activity against vancomycin-resistant Enterococcus faecium ATCC 700221 assessed as reduction of CFU using in vitro PK/PD model with 120 mg/24 hr continuous infusion simulated regimen after 48 hrs | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Pharmacokinetic/pharmacodynamic factors influencing emergence of resistance to linezolid in an in vitro model. |
| AID558498 | Antimicrobial activity against vancomycin-resistant Staphylococcus aureus 509 measured on day 15 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID456045 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis after 18 hrs by twofold microbroth dilution method | 2009 | Bioorganic & medicinal chemistry, Oct-01, Volume: 17, Issue:19 | Design, synthesis and biological evaluations of novel 7-[3-(1-aminocycloalkyl)pyrrolidin-1-yl]-6-desfluoro-8-methoxyquinolones with potent antibacterial activity against multi-drug resistant Gram-positive bacteria. |
| AID555742 | Antibacterial activity against methicillin-resistant, Linezolid non-susceptible coagulase-negative Staphylococcus epidermidis 345 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Antistaphylococcal activity of dihydrophthalazine antifolates, a family of novel antibacterial drugs. |
| AID1609264 | Bactericidal activity against methicillin-resistant Staphylococcus epidermidis NRS101 incubated for 18 to 20 hrs followed by replating on tryptic soy agar plate and further incubated for 18 to 24 hrs by CLSI-based broth microdilution assay | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Phenylthiazoles with nitrogenous side chain: An approach to overcome molecular obesity. |
| AID1721021 | Ratio of MIC for antitubercular activity against linezolid-resistant Mycobacterium tuberculosis to MIC for antitubercular activity against Mycobacterium tuberculosis H37Rv | 2020 | Journal of medicinal chemistry, 09-10, Volume: 63, Issue:17 | Discovery of a Conformationally Constrained Oxazolidinone with Improved Safety and Efficacy Profiles for the Treatment of Multidrug-Resistant Tuberculosis. |
| AID560802 | Apparent oral clearance in human adults with pulmonary tuberculosis at 600 mg administered daily for 7 days | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Population pharmacokinetics of linezolid in adults with pulmonary tuberculosis. |
| AID542909 | Antimicrobial activity against Bacillus anthracis infected in in vitro hollow fiber PK/PD model assessed as prevention of bacterial regrowth at 800 mg administered once every 24 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID574071 | Tmax in CF-1 mouse serum at 10 mg/kg, po | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | In vivo activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. |
| AID625290 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver fatty | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID292667 | Inhibition of mitochondrial protein synthesis in Escherichia coli assessed as [35S]methionine incorporation method | 2007 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 17, Issue:18 | A distal methyl substituent attenuates mitochondrial protein synthesis inhibition in oxazolidinone antibacterials. |
| AID562192 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus 525 measured after 10 antibiotic-free subculturing by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID548530 | Antimicrobial activity against Vancomycin-nonsusceptible Enterococcus faecalis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Activities of dalbavancin against a worldwide collection of 81,673 gram-positive bacterial isolates. |
| AID572557 | Antibacterial activity against Mycobacterium tuberculosis H37Rv by agar proportion method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | In vitro activities of linezolid against clinical isolates of Mycobacterium tuberculosis complex isolated in Taiwan over 10 years. |
| AID516163 | Antibacterial activity against methicillin-resistant Staphylococcus aureus clinical isolates assessed as resistant isolates by EUCAST method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | In vitro activity of telavancin against a contemporary worldwide collection of Staphylococcus aureus isolates. |
| AID1312949 | Bactericidal activity against methicillin-resistant Staphylococcus aureus USA200 NRS383 clinical isolate after 20 hrs by broth microdilution method | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10 | Second-Generation Phenylthiazole Antibiotics with Enhanced Pharmacokinetic Properties. |
| AID390338 | Antimicrobial activity against ampC beta-lactamase producing multidrug-resistant Klebsiella pneumoniae 2262 | 2008 | Journal of natural products, Dec, Volume: 71, Issue:12 | Citreamicins with potent gram-positive activity. |
| AID524980 | Antibacterial activity against Streptococcus mitis clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Comparative surveillance study of telavancin activity against recently collected gram-positive clinical isolates from across the United States. |
| AID285035 | Antimicrobial activity against Rothia mucilaginosa at 2 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID1117393 | Antimicrobial activity against Escherichia coli SG458 assessed as inhibition zone at 37 degC for 24 hrs by agar diffusion method | 2010 | MedChemComm, Aug-01, Volume: 1, Issue:2 | Syntheses and biological evaluation of new cephalosporin-oxazolidinone conjugates. |
| AID511382 | Antibacterial activity against Enterococcus faecalis by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Comparative in vitro activities of nemonoxacin (TG-873870), a novel nonfluorinated quinolone, and other quinolones against clinical isolates. |
| AID1304848 | Antibacterial activity against methicillin-resistant Staphylococcus aureus clinical isolate 2 incubated for 16 hrs by broth microdilution method in presence of Cu2+ | 2016 | Journal of medicinal chemistry, 04-28, Volume: 59, Issue:8 | Structure-Activity Relationships of a Diverse Class of Halogenated Phenazines That Targets Persistent, Antibiotic-Tolerant Bacterial Biofilms and Mycobacterium tuberculosis. |
| AID1547711 | Antibacterial activity against Staphylococcus epidermidis ATCC 35547 by broth microdilution method | 2020 | ACS medicinal chemistry letters, Mar-12, Volume: 11, Issue:3 | Structure-Activity Relationship for the Oxadiazole Class of Antibacterials. |
| AID523805 | Antimicrobial activity against oxacillin-susceptible Staphylococcus aureus assessed as inhibition of microbial growth at 0.5 ug/ml by CLSI method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative activities of TR-700 (torezolid) against staphylococcal blood isolates collected in Spain. |
| AID323783 | Antimicrobial activity against bioluminescent methicillin-resistant Staphylococcus aureus Xen1 | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Rapid bactericidal activity of daptomycin against methicillin-resistant and methicillin-susceptible Staphylococcus aureus peritonitis in mice as measured with bioluminescent bacteria. |
| AID68385 | In vitro antibacterial activity against Enterococcus faecium strain UC12712 | 1996 | Journal of medicinal chemistry, Feb-02, Volume: 39, Issue:3 | Synthesis and antibacterial activity of U-100592 and U-100766, two oxazolidinone antibacterial agents for the potential treatment of multidrug-resistant gram-positive bacterial infections. |
| AID278911 | Antibacterial activity against community-acquired methicillin-resistant Staphylococcus aureus | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | In vitro antibacterial activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. |
| AID520614 | Cmax in BALB/c mouse serum at 25 mg/kg, sc TID for 4 weeks by HPLC method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | In vivo therapeutic effect of gatifloxacin on BALB/c mice infected with Nocardia brasiliensis. |
| AID370020 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus Smith infected in C3H mouse assessed as eradication at 12.5 mg/kg/day, iv administered within 15 mins of infection assessed per gram of kidney measured after 48 hrs by organ burd | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vivo efficacy of a novel oxazolidinone compound in two mouse models of infection. |
| AID562393 | Antimicrobial activity against oxacillin-resistant Staphylococcus epidermidis clinical isolates assessed as percent susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID278922 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | In vitro antibacterial activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. |
| AID245414 | Minimum inhibitory concentration against methicillin-susceptible Staphylococcus aureus UC9213; Range is 2-4 ug/mL | 2005 | Journal of medicinal chemistry, Jul-28, Volume: 48, Issue:15 | Conformational constraint in oxazolidinone antibacterials. Synthesis and structure-activity studies of (azabicyclo[3.1.0]hexylphenyl)oxazolidinones. |
| AID534155 | Antimicrobial activity against linezolid-resistant Enterococcus faecalis 3128 harboring G2576U mutation in peptidyl transferase centre by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains. |
| AID495878 | Antibacterial activity against methicillin-resistant Staphylococcus aureus COL infected New Zealand White rabbit aortic valve endocarditis model assessed as decrease in bacterial colony forming unit in vegetation at 75 mg/kg, sc dosed every 8 hrs for 4 da | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Ceftobiprole is superior to vancomycin, daptomycin, and linezolid for treatment of experimental endocarditis in rabbits caused by methicillin-resistant Staphylococcus aureus. |
| AID511431 | Antimicrobial activity against Clostridium perfringens LFM1 assessed as susceptibility breakpoint by EUCAST method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Resistance to linezolid in a porcine Clostridium perfringens strain carrying a mutation in the rplD gene encoding the ribosomal protein L4. |
| AID372667 | Antimicrobial activity against Pseudomonas aeruginosa MTCC 3541 after 24 hrs by agar dilution assay | 2009 | European journal of medicinal chemistry, Apr, Volume: 44, Issue:4 | Synthesis and antibacterial activity of some new 2,3-dimethoxy-3-hydroxy-2-(1-phenyl-3-aryl-4-pyrazolyl)chromanones. |
| AID565756 | Antimicrobial activity against oxacillin-resistant Staphylococcus epidermidis clinical isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID542921 | Antimicrobial activity against mutant Bacillus anthracis | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID410114 | Antimicrobial activity against erm (B) Streptococcus pyogenes msr610 by NCCLS method | 2008 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 18, Issue:23 | Design at the atomic level: design of biaryloxazolidinones as potent orally active antibiotics. |
| AID287268 | Antimicrobial activity against methicillin-resistant coagulase-negative Staphylococcus by agar dilution method | 2007 | European journal of medicinal chemistry, Feb, Volume: 42, Issue:2 | Structure-antibacterial activity of arylcarbonyl- and arylsulfonyl-piperazine 5-triazolylmethyl oxazolidinones. |
| AID390337 | Antimicrobial activity against Klebsiella pneumoniae 2239 | 2008 | Journal of natural products, Dec, Volume: 71, Issue:12 | Citreamicins with potent gram-positive activity. |
| AID581657 | Antibacterial activity against normal phenotype Staphylococcus aureus at pH 7.4 after 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Intracellular activity of antibiotics in a model of human THP-1 macrophages infected by a Staphylococcus aureus small-colony variant strain isolated from a cystic fibrosis patient: pharmacodynamic evaluation and comparison with isogenic normal-phenotype a |
| AID565747 | Antimicrobial activity against Enterococcus faecium clinical isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID640892 | Antibacterial activity against methicillin-susceptible Staphylococcus epidermidis by agar microdilution method | 2012 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 22, Issue:2 | Design, synthesis, and structure-activity relationship studies of conformationally restricted mutilin 14-carbamates. |
| AID1327105 | Antibacterial activity against Escherichia coli NCIM 2688 at 30 ug/ml measured after 8 hrs by spectrophotometric method | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Design, synthesis and biological evaluation of novel azaspiro analogs of linezolid as antibacterial and antitubercular agents. |
| AID1395673 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus ATCC 6538 after 18 hrs by broth microdilution assay | 2018 | European journal of medicinal chemistry, May-10, Volume: 151 | Phenylthiazoles with tert-Butyl side chain: Metabolically stable with anti-biofilm activity. |
| AID1482581 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus A-1178 infected in neutropenic murine thigh infection model assessed as decrease in bacterial load in thighs administered po 22 hrs post infection measured 24 hrs post infection | 2017 | Journal of medicinal chemistry, 05-11, Volume: 60, Issue:9 | Discovery and Optimization of Isoquinoline Ethyl Ureas as Antibacterial Agents. |
| AID442576 | Antibacterial activity against Enterococcus faecalis MTCC439 after 24 hrs by spectrophotometry | 2010 | European journal of medicinal chemistry, Feb, Volume: 45, Issue:2 | Synthesis of nitroimidazole derived oxazolidinones as antibacterial agents. |
| AID524957 | Antibacterial activity against methicillin-resistant coagulase-negative Staphylococcus epidermidis clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Comparative surveillance study of telavancin activity against recently collected gram-positive clinical isolates from across the United States. |
| AID1680048 | Antibacterial activity against carbapenem-resistant Klebsiella pneumoniae clinical isolate 8 assessed as reduction in bacterial growth incubated for 16 to 20 hrs by CLSI-based broth microdilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Synthesis and antibacterial bioactivities of cationic deacetyl linezolid amphiphiles. |
| AID1862421 | Antibacterial activity against Enterococcus faecalis ATCC 29212 assessed as reduction in visible bacterial growth incubated for 18 to 20 hrs by CLSI based broth microdilution analysis | 2022 | European journal of medicinal chemistry, Oct-05, Volume: 240 | Membrane acting Povarov-Doebner derived compounds potently disperse preformed multidrug resistant Gram-positive bacterial biofilms. |
| AID576411 | Total clearance in two-compartment pharmacokinetic/pharmacodynamic model at 200 mg, bid administered as 0.5 hrs infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID519993 | Antimicrobial activity against vancomycin-resistant Enterococcus faecium nosocomial isolate | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID572010 | Antibacterial activity against Fusobacterium varium by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID1117380 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus 134/93 assessed as inhibition zone at 37 degC for 24 hrs by agar diffusion method | 2010 | MedChemComm, Aug-01, Volume: 1, Issue:2 | Syntheses and biological evaluation of new cephalosporin-oxazolidinone conjugates. |
| AID363434 | Antibacterial activity against Streptococcus pneumoniae ATCC 6303 | 2008 | Journal of medicinal chemistry, Sep-11, Volume: 51, Issue:17 | Novel dual-targeting benzimidazole urea inhibitors of DNA gyrase and topoisomerase IV possessing potent antibacterial activity: intelligent design and evolution through the judicious use of structure-guided design and structure-activity relationships. |
| AID284952 | Antimicrobial activity against Bacillus cereus at 0.12 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID285028 | Antimicrobial activity against Micrococcus luteus at 0.5 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID565077 | Antibacterial activity against community-acquired methicillin-resistant Staphylococcus aureus 144 by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Pharmacodynamic profile of tigecycline against methicillin-resistant Staphylococcus aureus in an experimental pneumonia model. |
| AID390324 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus 29213 | 2008 | Journal of natural products, Dec, Volume: 71, Issue:12 | Citreamicins with potent gram-positive activity. |
| AID206864 | Antibacterial activity against Methicillin-suceptible Staphylococcus aureus UC9218 | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | Synthesis and biological evaluation of benzazepine oxazolidinone antibacterials. |
| AID532794 | Antibacterial activity against vancomycin-intermediate Staphylococcus aureus AMC11094 after 24 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Improved antimicrobial activity of linezolid against vancomycin-intermediate Staphylococcus aureus. |
| AID210369 | In vitro antibacterial activity against Streptococcus pneumoniae | 2003 | Bioorganic & medicinal chemistry letters, Jul-21, Volume: 13, Issue:14 | Synthesis and antibacterial activity of oxazolidinone containing sulphonyl group. |
| AID297130 | Antibacterial activity against Klebsiella pneumoniae NCTN9632 by agar plate dilution method | 2007 | Journal of medicinal chemistry, Aug-23, Volume: 50, Issue:17 | Discovery of 1,4-dihydroxy-2-naphthoate [corrected] prenyltransferase inhibitors: new drug leads for multidrug-resistant gram-positive pathogens. |
| AID444056 | Fraction escaping gut-wall elimination in human | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3 | Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. |
| AID520513 | AUC in New Zealand rabbit osteomyelitis model at 40 mg/kg, sc administered every 6 hrs for 4 days | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Efficacies of ceftobiprole medocaril and comparators in a rabbit model of osteomyelitis due to methicillin-resistant Staphylococcus aureus. |
| AID565748 | Antimicrobial activity against Enterococcus faecalis expressing VanB gene clinical isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID278924 | Antibacterial activity against fluoroquinolone-resistant Streptococcus pneumoniae | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | In vitro antibacterial activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. |
| AID370023 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus Smith infected in C3H mouse assessed as reduction in log number of CFU at 25 mg/kg/day, iv administered within 15 mins of infection measured after 48 hrs by organ burden assay re | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vivo efficacy of a novel oxazolidinone compound in two mouse models of infection. |
| AID560374 | Selectivity ratio of MIC for Enterococcus faecalis ATCC 29212 in presence of 4% HSA to MIC for Enterococcus faecalis ATCC 29212 | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Impact of human serum albumin on oritavancin in vitro activity against enterococci. |
| AID524684 | Antibacterial activity against coagulase-negative Staphylococcus clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro antibacterial activity of CE-156811, a novel analog derived from hygromycin A. |
| AID559561 | Antimicrobial activity against compound-susceptible Coxiella burnetii isolate CP7 obtained from patient with acute Q fever infected in african green monkey Vero cells after 24 hrs by shell vial assay | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Bacteriostatic and bactericidal activities of tigecycline against Coxiella burnetii and comparison with those of six other antibiotics. |
| AID373990 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus 525 after 50 passages with Linezolid measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID278907 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | In vitro antibacterial activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. |
| AID1778661 | Bactericidal activity against penicillin-susceptible Bacillus subtilis ATCC 9372 measured after 24 hrs by CLSI protocol based method | 2021 | European journal of medicinal chemistry, Oct-05, Volume: 221 | Design, synthesis and evaluation of novel 9-arylalkyl-10-methylacridinium derivatives as highly potent FtsZ-targeting antibacterial agents. |
| AID532808 | Antibacterial activity against vancomycin-susceptible Staphylococcus aureus BR2 after 24 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Improved antimicrobial activity of linezolid against vancomycin-intermediate Staphylococcus aureus. |
| AID1400035 | Antibacterial activity against Mycobacterium smegmatis ATCC 607 incubated for 48 hrs under aerobic condition by MABA | 2018 | Bioorganic & medicinal chemistry, 09-15, Volume: 26, Issue:17 | An antimycobacterial pleuromutilin analogue effective against dormant bacilli. |
| AID532812 | Antibacterial activity against vancomycin-intermediate Staphylococcus aureus Mu50 phenotypic revertant after 24 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Improved antimicrobial activity of linezolid against vancomycin-intermediate Staphylococcus aureus. |
| AID1584839 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis BM 4575 clinical isolate after 18 to 24 hrs by microdilution assay | 2018 | European journal of medicinal chemistry, Nov-05, Volume: 159 | 1-(2-Hydroxybenzoyl)-thiosemicarbazides are promising antimicrobial agents targeting d-alanine-d-alanine ligase in bacterio. |
| AID439890 | Antibacterial activity against Escherichia coli ATCC 8739 after 18 hrs by agar dilution method | 2010 | European journal of medicinal chemistry, Jan, Volume: 45, Issue:1 | Synthesis and antibacterial activity of isothiazolyl oxazolidinones and analogous 3(2H)-isothiazolones. |
| AID1056355 | Antibacterial activity against Haemophilus influenzae SR27914 clinical isolate assessed as parasite growth inhibition by CLSI broth microdilution method | 2013 | ACS medicinal chemistry letters, Nov-14, Volume: 4, Issue:11 | Potent oxazolidinone antibacterials with heteroaromatic C-ring substructure. |
| AID583393 | Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus isolate NJ992 assessed as bacterial count at 16 times MIC after 24 hrs by colony counting method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | In vitro activity of the new multivalent glycopeptide-cephalosporin antibiotic TD-1792 against vancomycin-nonsusceptible Staphylococcus isolates. |
| AID244925 | Minimum inhibition concentration against Haemophilus influenzae strains | 2005 | Bioorganic & medicinal chemistry letters, Jun-02, Volume: 15, Issue:11 | Biaryl isoxazolinone antibacterial agents. |
| AID285311 | Antimicrobial activity against Listeria monocytogenes by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Daptomycin susceptibility of unusual gram-positive bacteria: comparison of results obtained by the Etest and the broth microdilution method. |
| AID573388 | Antibacterial activity against Pasteurella multocida by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID574074 | Half life in CF-1 mouse at 10 mg/kg, po | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | In vivo activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. |
| AID132755 | In vivo antibacterial activity in a murine systemic infection model | 2002 | Journal of medicinal chemistry, Aug-29, Volume: 45, Issue:18 | Synthesis of conformationally constrained analogues of linezolid: structure-activity relationship (SAR) studies on selected novel tricyclic oxazolidinones. |
| AID404934 | Antibacterial activity against methicillin-resistant Staphylococcus aureus by CLSI dilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro activities of CG400549, a novel FabI inhibitor, against recently isolated clinical staphylococcal strains in Korea. |
| AID562167 | Antimicrobial activity against vancomycin-resistant Staphylococcus aureus 510 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID516159 | Antibacterial activity against methicillin-resistant Staphylococcus aureus clinical isolates by CLSi method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | In vitro activity of telavancin against a contemporary worldwide collection of Staphylococcus aureus isolates. |
| AID524961 | Antibacterial activity against methicillin-resistant coagulase-negative Staphylococcus sciuri clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Comparative surveillance study of telavancin activity against recently collected gram-positive clinical isolates from across the United States. |
| AID562160 | Antimicrobial activity against heterogeneous vancomycin-intermediate Staphylococcus aureus 168 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID1056348 | Inhibition of rat forebrain MAO-A using [14C]5-HT as substrate at 30 uM preincubated for 20 mins followed by substrate addition measured after 5 mins by liquid scintillation counting analysis | 2013 | ACS medicinal chemistry letters, Nov-14, Volume: 4, Issue:11 | Potent oxazolidinone antibacterials with heteroaromatic C-ring substructure. |
| AID1311370 | Antibacterial activity against Mycobacterium avium 104 measured after 7 days by broth microdilution assay | 2016 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15 | An evolved oxazolidinone with selective potency against Mycobacterium tuberculosis and gram positive bacteria. |
| AID206592 | In vitro antibacterial activity against Staphylococcus aureus | 2003 | Bioorganic & medicinal chemistry letters, Jul-07, Volume: 13, Issue:13 | Synthesis and in vitro activity of new methylenepiperidinyl and methylenepyrrolidinyl oxazolidinone antibacterial agents. |
| AID520768 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus infected in New Zealand rabbit osteomyelitis model assessed as improvement in extent of bone remodeling at 60 mg/kg, po administered every 8 hrs for 4 weeks measured on week 8 post | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Efficacies of ceftobiprole medocaril and comparators in a rabbit model of osteomyelitis due to methicillin-resistant Staphylococcus aureus. |
| AID390325 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus 1137 | 2008 | Journal of natural products, Dec, Volume: 71, Issue:12 | Citreamicins with potent gram-positive activity. |
| AID206872 | Antibacterial activity against Staphylococcus aureus (SA1011) | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | Novel oxazolidinone-quinolone hybrid antimicrobials. |
| AID370021 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus Smith infected in C3H mouse assessed as eradication at 6.25 mg/kg/day, iv administered within 15 mins of infection assessed per gram of kidney measured after 48 hrs by organ burd | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vivo efficacy of a novel oxazolidinone compound in two mouse models of infection. |
| AID1603314 | Antimicrobial activity against Escherichia coli SQ110 LPTD measured after 16 hrs by broth microdilution method | 2019 | ACS medicinal chemistry letters, Mar-14, Volume: 10, Issue:3 | Expanded Structure-Activity Studies of Lipoxazolidinone Antibiotics. |
| AID1504966 | Antitubercular activity against Mycobacterium tuberculosis H37Rv ATCC 27294 incubated for 10 days under low oxygen condition followed by second incubation under aerobic condition for 28 hrs by LORA | 2017 | ACS medicinal chemistry letters, Dec-14, Volume: 8, Issue:12 | Antitubercular Nitroimidazoles Revisited: Synthesis and Activity of the Authentic 3-Nitro Isomer of Pretomanid. |
| AID730747 | Antibacterial activity against methicillin-resistant Staphylococcus aureus 1279-07-USA300 assessed as growth inhibition | 2013 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 23, Issue:6 | Novel 3-O-carbamoyl erythromycin A derivatives (carbamolides) with activity against resistant staphylococcal and streptococcal isolates. |
| AID1197129 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis 99 clinical isolate after 16 to 20 hrs by broth microdilution method | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3 | Structure-activity relationship for the oxadiazole class of antibiotics. |
| AID1139118 | Half life in rat at 2.8 to 9.5 mg/kg, iv | 2014 | Bioorganic & medicinal chemistry letters, May-01, Volume: 24, Issue:9 | Successful application of serum shift prediction models to the design of dual targeting inhibitors of bacterial gyrase B and topoisomerase IV with improved in vivo efficacy. |
| AID1435925 | Antibacterial activity against methicillin/erythromycin/tetracycline-resistant Staphylococcus aureus USA300 NRS384 clinical isolate after 18 to 20 hrs by broth microdilution method | 2017 | European journal of medicinal chemistry, Jan-27, Volume: 126 | Phenylthiazole antibiotics: A metabolism-guided approach to overcome short duration of action. |
| AID671563 | Antibacterial activity against Haemophilus influenzae 551 | 2012 | Journal of medicinal chemistry, Jan-26, Volume: 55, Issue:2 | Fluorocyclines. 2. Optimization of the C-9 side-chain for antibacterial activity and oral efficacy. |
| AID1308236 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis 99 clinical isolate incubated for 16 to 20 hrs by microdilution method | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10 | Structure-Activity Relationship for the 4(3H)-Quinazolinone Antibacterials. |
| AID245023 | In vitro minimum inhibitory concentration against Enterococcus faecium (6A-VRE) | 2005 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 15, Issue:12 | Synthesis and antibacterial activity of novel (un)substituted benzotriazolyl oxazolidinone derivatives. |
| AID1395709 | Bactericidal activity against methicillin-resistant Staphylococcus aureus NRS386 incubated fo 18 hrs followed by re-plating on tryptic soy agar plates at 37 degC for 18 hrs by broth microdilution assay | 2018 | European journal of medicinal chemistry, May-10, Volume: 151 | Phenylthiazoles with tert-Butyl side chain: Metabolically stable with anti-biofilm activity. |
| AID1649285 | Antibacterial activity against Vancomycin-resistant Enterococcus faecalis SR7914 (VanA) assessed as inhibition of bacterial growth incubated for 20 hrs by microdilution broth method | |||
| AID245167 | Minimum inhibitory concentration against homogeneously methicillin-resistant Staphylococcus aureus A27223 | 2005 | Bioorganic & medicinal chemistry letters, Jun-02, Volume: 15, Issue:11 | Synthesis and antibacterial activity of dihydro-1,2-oxazine and 2-pyrazoline oxazolidinones: novel analogs of linezolid. |
| AID548533 | Antimicrobial activity against Beta-hemolytic Streptococcus by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Activities of dalbavancin against a worldwide collection of 81,673 gram-positive bacterial isolates. |
| AID65385 | Inhibitory activity against Enterococcus faecalis UC9217 | 2000 | Journal of medicinal chemistry, Mar-09, Volume: 43, Issue:5 | Substituent effects on the antibacterial activity of nitrogen-carbon-linked (azolylphenyl)oxazolidinones with expanded activity against the fastidious gram-negative organisms Haemophilus influenzae and Moraxella catarrhalis. |
| AID133299 | Minimum inhibitory concentration of the subcutaneously administered compound evaluated against Staphylococcus aureus HT-17 strain in mice (SC) | 2000 | Bioorganic & medicinal chemistry letters, Aug-07, Volume: 10, Issue:15 | Improved antibacterial activities of coumarin antibiotics bearing 5',5'-dialkylnoviose: biological activity of RU79115. |
| AID23015 | Steady-state volume distribution was evaluated in male Dawley rats at a dose of 10 mg/kg when taken intravenously | 1998 | Journal of medicinal chemistry, Dec-17, Volume: 41, Issue:26 | Nitrogen-carbon-linked (azolylphenyl)oxazolidinones with potent antibacterial activity against the fastidious gram-negative organisms Haemophilus influenzae and Moraxella catarrhalis. |
| AID1609260 | Bactericidal activity against cephalosporin-resistant Streptococcus pneumoniae ATCC 51916 incubated for 18 to 20 hrs followed by replating on tryptic soy agar plate and further incubated for 18 to 24 hrs by CLSI-based broth microdilution assay | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Phenylthiazoles with nitrogenous side chain: An approach to overcome molecular obesity. |
| AID571763 | Antimicrobial activity against Escherichia coli K-12 3-AG300 harboring AcrB-F628F mutant gene | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Site-directed mutagenesis reveals amino acid residues in the Escherichia coli RND efflux pump AcrB that confer macrolide resistance. |
| AID1151733 | Antibacterial activity against methicillin-resistant Staphylococcus aureus by agar dilution method | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID645039 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus ATCC 29213 after 16 to 20 hrs by microbroth dilution method | 2012 | European journal of medicinal chemistry, Apr, Volume: 50 | Synthesis and preliminary antibacterial evaluation of Linezolid-like 1,2,4-oxadiazole derivatives. |
| AID370031 | Antibacterial activity against methicillin-resistant Staphylococcus aureus COL infected in po dosed DBA/2 mouse localized infection model assessed as reduction of number of CFU per gram of thigh administered 2 hrs postinfection thrice daily for 1 day and | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vivo efficacy of a novel oxazolidinone compound in two mouse models of infection. |
| AID533955 | Antimicrobial activity against Staphylococcus aureus infected in THP1 cells assessed as log reduction in bacterial count after 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Cellular pharmacodynamics of the novel biaryloxazolidinone radezolid: studies with infected phagocytic and nonphagocytic cells, using Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Legionella pneumophila. |
| AID581654 | Antibacterial activity against Staphylococcus aureus SCV isolated from cystic fibrosis patient at pH 7.4 after 48 hrs by broth microdilution method in absence of thymidine | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Intracellular activity of antibiotics in a model of human THP-1 macrophages infected by a Staphylococcus aureus small-colony variant strain isolated from a cystic fibrosis patient: pharmacodynamic evaluation and comparison with isogenic normal-phenotype a |
| AID571789 | Antibacterial activity against Clostridium bolteae by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID576865 | Bactericidal activity against 1 hr peripheral compartment culture samples of Enterococcus faecalis Ef1497 MutM3 in two-compartment pharmacokinetic/pharmacodynamic model assessed as effect on bacterial count at 200 mg, bid administered as 0.5 hr infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID1778650 | Antibacterial activity against penicillin-susceptible Escherichia coli ATCC 25922 assessed as inhibition of bacterial growth measured by broth microdilution method | 2021 | European journal of medicinal chemistry, Oct-05, Volume: 221 | Design, synthesis and evaluation of novel 9-arylalkyl-10-methylacridinium derivatives as highly potent FtsZ-targeting antibacterial agents. |
| AID520617 | Antimicrobial activity against Nocardia brasiliensis HUJEG-1 by broth macrodilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | In vivo therapeutic effect of gatifloxacin on BALB/c mice infected with Nocardia brasiliensis. |
| AID1151764 | Antibacterial activity against penicillin intermediate-sensitive Streptococcus pneumoniae ATCC 49619 clinical isolate in po dosed mouse systemic infection model | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID206599 | In vitro antibacterial activity against ciprofloxacin-resistant Staphylococcus aureus (CRSA) | 2003 | Bioorganic & medicinal chemistry letters, Jul-07, Volume: 13, Issue:13 | Synthesis and in vitro activity of new methylenepiperidinyl and methylenepyrrolidinyl oxazolidinone antibacterial agents. |
| AID523818 | Antimicrobial activity against oxacillin-resistant coagulase-negative Staphylococcus aureus assessed as inhibition of microbial growth at =< 0.25 ug/ml by CLSI method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative activities of TR-700 (torezolid) against staphylococcal blood isolates collected in Spain. |
| AID560514 | Antimicrobial activity against SCCmec type IV vancomycin-intermediate Staphylococcus aureus isolate 06b41 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID244819 | Minimum inhibitory concentration against Streptococcus pneumoniae A9585 | 2005 | Bioorganic & medicinal chemistry letters, Jun-02, Volume: 15, Issue:11 | Synthesis and antibacterial activity of dihydro-1,2-oxazine and 2-pyrazoline oxazolidinones: novel analogs of linezolid. |
| AID1265131 | Antibacterial activity against methicillin-sensitive Staphylococcus epidermidis ATCC 12228 | 2015 | European journal of medicinal chemistry, Dec-01, Volume: 106 | Synthesis and biological evaluation of novel 5-(hydroxamic acid)methyl oxazolidinone derivatives. |
| AID1424068 | Antibiotic activity against methicillin-resistant Staphylococcus aureus isolate CAIRD148 by broth microdilution assay or Alamar blue dye based colorimetric assay | 2017 | Journal of natural products, 04-28, Volume: 80, Issue:4 | The Berkeleylactones, Antibiotic Macrolides from Fungal Coculture. |
| AID475006 | Antibacterial activity against Escherichia coli LCB0011 by two fold serial dilution method | 2010 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 20, Issue:7 | Synthesis, crystal and antibacterial studies of diversely functionalized tetrahydropyridin-4-ol. |
| AID1058370 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus after 24 hrs by microdilution method | 2013 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 23, Issue:24 | Anti-tubercular agents. Part 8: synthesis, antibacterial and antitubercular activity of 5-nitrofuran based 1,2,3-triazoles. |
| AID730743 | Antibacterial activity against macrolides, lincosamides, streptogramin B and methicillin-resistant Staphylococcus aureus 1609-09 harboring cfr gene assessed as growth inhibition | 2013 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 23, Issue:6 | Novel 3-O-carbamoyl erythromycin A derivatives (carbamolides) with activity against resistant staphylococcal and streptococcal isolates. |
| AID584993 | Antibacterial activity against Staphylococcus aureus XU21 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Identification and characterization of the multidrug resistance gene cfr in a Panton-Valentine leukocidin-positive sequence type 8 methicillin-resistant Staphylococcus aureus IVa (USA300) isolate. |
| AID1649292 | Antibacterial activity against Streptococcus pneumoniae SR11031 (PRSP) assessed as inhibition of bacterial growth incubated for 20 hrs by microdilution broth method | |||
| AID1853454 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis ATCC 51575 assessed as bacterial growth inhibition incubated for 18 to 20 hrs by CLSI based broth microdilution assay | 2021 | RSC medicinal chemistry, Nov-17, Volume: 12, Issue:11 | SF |
| AID1553378 | Half life in mouse liver microsomes | 2019 | Bioorganic & medicinal chemistry letters, 09-15, Volume: 29, Issue:18 | Incorporation of a chiral gem-disubstituted nitrogen heterocycle yields an oxazolidinone antibiotic with reduced mitochondrial toxicity. |
| AID520031 | Antimicrobial activity against Enterococcus faecium A8130 | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID542680 | fAUC (24 hrs) in Bacillus anthracis infected in vitro hollow fiber PK/PD model at simulated dose of 100 mg administered every 24 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID388046 | Antibacterial activity against Haemophilus influenzae MSD2261 after 18 to 20 hrs by serial dilution method | 2008 | Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19 | Isolation, structure, and antibacterial activity of thiazomycin A, a potent thiazolyl peptide antibiotic from Amycolatopsis fastidiosa. |
| AID285050 | Antimicrobial activity against Listeria monocytogenes by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID370011 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus Smith infected in C3H mouse assessed as reduction in log number of CFU at 25 mg/kg/day, po administered within 15 mins of infection measured after 48 hrs by organ burden assay re | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vivo efficacy of a novel oxazolidinone compound in two mouse models of infection. |
| AID565480 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro bactericidal activity of iclaprim in human plasma. |
| AID562632 | Antimicrobial activity against Streptococcus pneumoniae by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | In vitro activities of three new dihydrofolate reductase inhibitors against clinical isolates of gram-positive bacteria. |
| AID1723499 | Antibacterial activity against Enterococcus faecalis HM-335 incubated for 18 to 20 hrs under aerobic condition by CLSI protocol based broth microdilution assay | |||
| AID1703712 | Antibacterial activity against methicillin-resistant Staphylococcus aureus USA400 NRS123 assessed as inhibition of bacterial growth measured after 18 to 20 hrs by CLSI protocol based broth microdilution method | 2020 | European journal of medicinal chemistry, Sep-15, Volume: 202 | Evaluation of N-phenyl-2-aminothiazoles for treatment of multi-drug resistant and intracellular Staphylococcus aureus infections. |
| AID566579 | Antimicrobial activity against Staphylococcus epidermidis ATCC 12228 by conventional agar-dilution method | 2011 | European journal of medicinal chemistry, Jan, Volume: 46, Issue:1 | Discovery of a novel nitroimidazolyl-oxazolidinone hybrid with potent anti Gram-positive activity: Synthesis and antibacterial evaluation. |
| AID1327113 | Antibacterial activity against Staphylococcus aureus NCIM 2079 at 3 ug/ml measured after 12 hrs by spectrophotometric method | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Design, synthesis and biological evaluation of novel azaspiro analogs of linezolid as antibacterial and antitubercular agents. |
| AID477373 | Antibacterial activity against Bacillus cereus MTCC 430 after 24 hrs | 2009 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13 | Synthesis and antibacterial evaluation of isoxazolinyl oxazolidinones: Search for potent antibacterial. |
| AID348603 | Antibacterial activity against vancomycin-resistant Enterococcus faecium 1 after 18 to 20 hrs by agar dilution method | 2008 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 18, Issue:21 | Synthesis and antibacterial activities of novel oxazolidinones having cyclic sulfonamide moieties. |
| AID573122 | Antibacterial activity against coagulase-negative and oxacillin-resistant Staphylococcus aureus by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID285106 | Antimicrobial activity against viridans group Streptococcus mutans at <= 0.06 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID1361102 | Bacteriostatic activity against methicillin-resistant Staphylococcus aureus USA800 NRS387 clinical isolate after 20 hrs by broth microdilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | N-(1,3,4-oxadiazol-2-yl)benzamide analogs, bacteriostatic agents against methicillin- and vancomycin-resistant bacteria. |
| AID11797 | Maximum plasma concentration (Cmax) of compound (25 mg/kg) after po administration was determined Sprague-Dawley rat | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | The effect of remote chirality on the antibacterial activity of indolinyl, tetrahydroquinolyl and dihydrobenzoxazinyl oxazolidinones. |
| AID1770346 | Antibacterial activity against penicillin-resistant Staphylococcus aureus ATCC 31007 assessed as inhibition of bacterial growth measured after 20 hrs by two-fold microdilution assay | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Modification of 5-methylphenanthridium from benzothiazoles to indoles as potent FtsZ inhibitors: Broadening the antibacterial spectrum toward vancomycin-resistant enterococci. |
| AID392208 | Antibacterial activity against Staphylococcus aureus ATCC 29213 | 2009 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 19, Issue:2 | Antibacterial alkoxybenzamide inhibitors of the essential bacterial cell division protein FtsZ. |
| AID533962 | Antimicrobial activity against Legionella pneumophila ATCC 33153 infected in THP1 cells after 48hrs | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Cellular pharmacodynamics of the novel biaryloxazolidinone radezolid: studies with infected phagocytic and nonphagocytic cells, using Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Legionella pneumophila. |
| AID561747 | Antibacterial activity against Methicillin-resistant Staphylococcus aureus assessed as resistant isolates by CLSI broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Potency and bactericidal activity of iclaprim against recent clinical gram-positive isolates. |
| AID274226 | Antibacterial activity against Streptococcus pyogenes C-203 | 2006 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 16, Issue:20 | Synthesis and structure-activity studies of novel benzocycloheptanone oxazolidinone antibacterial agents. |
| AID1303405 | Antibacterial activity against Penicillin-resistant Streptococcus pneumoniae after 24 hrs by microdilution method | 2016 | Bioorganic & medicinal chemistry letters, 07-01, Volume: 26, Issue:13 | Identification of novel aminopiperidine derivatives for antibacterial activity against Gram-positive bacteria. |
| AID1687315 | Synergistic antibacterial activity against Acinetobacter baumannii ATCC 19606 in presence of 0.25 times MIC of colistin incubated for 18 to 20 hrs by broth microdilution method | 2020 | European journal of medicinal chemistry, Jan-15, Volume: 186 | Development of benzimidazole-based derivatives as antimicrobial agents and their synergistic effect with colistin against gram-negative bacteria. |
| AID1680052 | Antibacterial activity against carbapenem-resistant Klebsiella pneumoniae clinical isolate 4 assessed as reduction in bacterial growth incubated for 16 to 20 hrs by CLSI-based broth microdilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Synthesis and antibacterial bioactivities of cationic deacetyl linezolid amphiphiles. |
| AID284991 | Antimicrobial activity against Enterococcus casseliflavus at 1 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID542894 | fAUC (24 hrs) in Bacillus anthracis infected in vitro hollow fiber PK/PD model at simulated dose of 400 mg administered every 12 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID285509 | Antibacterial activity against Streptococcus viridans after 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | In vitro and in vivo antibacterial activities of heteroaryl isothiazolones against resistant gram-positive pathogens. |
| AID373843 | Antimicrobial activity against methicillin and vancomycin-resistant Staphylococcus aureus 510 after single-step resistance selection by agar dilution CLSI method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID1472760 | In vivo anti-virulence activity against methicillin-resistant Staphylococcus aureus LRSA202 infected in BALB/c mouse model assessed as reduction in bacterial load in heart at 0.4 mg bid for 3.5 days administered intraperitoneally 6 hrs post infection by s | 2018 | Journal of medicinal chemistry, 01-11, Volume: 61, Issue:1 | Novel Terminal Bipheny-Based Diapophytoene Desaturases (CrtN) Inhibitors as Anti-MRSA/VISR/LRSA Agents with Reduced hERG Activity. |
| AID285119 | Antimicrobial activity against viridans group Streptococcus parasanguis at <= 0.06 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID374014 | Antimicrobial activity against methicillin-resistant vancomycin-intermediate Staphylococcus aureus 504 after single-step resistance selection by agar dilution CLSI method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID369447 | Antimicrobial activity against Streptococcus group B after 20 to 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vitro activity of telavancin against gram-positive clinical isolates recently obtained in Europe. |
| AID545811 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus ATCC 33591 assessed as inhibition of biofilm formation after 24 hrs by serial dilution method in presence of 0.002% polysorbate 80 | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Oritavancin kills stationary-phase and biofilm Staphylococcus aureus cells in vitro. |
| AID573132 | Antibacterial activity against erythromycin-susceptible Streptococcus pyogenes assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID534162 | Antimicrobial activity against linezolid-resistant Staphylococcus sciuri by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains. |
| AID564829 | Antimicrobial activity against methicillin-resistant coagulase-negative Staphylococcus sciuri after 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID535772 | Antimicrobial activity against Mycobacterium ulcerans 1059 agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Rapid assessment of antibacterial activity against Mycobacterium ulcerans by using recombinant luminescent strains. |
| AID528836 | Antimicrobial activity against vancomycin-resistant Enterococcus sp. isolated from ICU patient wound assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID625279 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for bilirubinemia | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID1181168 | Antimicrobial activity against first mutant generation Mycobacterium tuberculosis 1024_18 assessed as fold shift in MIC relative to parent strain | 2014 | Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15 | Diarylthiazole: an antimycobacterial scaffold potentially targeting PrrB-PrrA two-component system. |
| AID541041 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 infected in Albino guiena pig assessed as no. of culture-negative cage fluid samples at 50 mg/kg measured on day 10 postinfection | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Linezolid alone or combined with rifampin against methicillin-resistant Staphylococcus aureus in experimental foreign-body infection. |
| AID581653 | Antibacterial activity against Staphylococcus aureus SCV isolated from cystic fibrosis patient in cation-adjusted MH 2 broth assessed as log reduction of extracellular CFU after 5 hrs | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Intracellular activity of antibiotics in a model of human THP-1 macrophages infected by a Staphylococcus aureus small-colony variant strain isolated from a cystic fibrosis patient: pharmacodynamic evaluation and comparison with isogenic normal-phenotype a |
| AID318365 | Antifungal activity against Candida albicans | 2007 | Proceedings of the National Academy of Sciences of the United States of America, May-01, Volume: 104, Issue:18 | Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties. |
| AID66572 | Antibacterial activity was determined against clinically isolated vancomycin-A resistant enterococci (VRE) strains (33 strains) | 2003 | Journal of medicinal chemistry, Mar-13, Volume: 46, Issue:6 | Synthesis and structure-activity relationships of 5-amino-6-fluoro-1-[(1R,2S)-2-fluorocyclopropan-1-yl]-8-methylquinolonecarboxylic acid antibacterials having fluorinated 7-[(3R)-3-(1-aminocyclopropan-1-yl)pyrrolidin-1-yl] substituents. |
| AID559787 | Antimicrobial activity against heterogeneous vancomycin-susceptible Staphylococcus aureus assessed as intermediate isolates by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID1904913 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus ATCC 6538 incubated for 18 to 20 hrs by broth microdilution method | 2022 | European journal of medicinal chemistry, Apr-15, Volume: 234 | Exploring the structure-activity relationships of diphenylurea as an antibacterial scaffold active against methicillin- and vancomycin-resistant Staphylococcus aureus. |
| AID576421 | Elimination half-life in healthy human at 600 mg, iv, bid administered as 0.5 hr infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID424766 | Antibacterial activity against vancomycin, linezolid-resistant Enterococcus faecium CL5791 after 20 hrs by twofold serial broth dilution method | 2009 | Journal of natural products, May-22, Volume: 72, Issue:5 | Thiazomycins, thiazolyl peptide antibiotics from Amycolatopsis fastidiosa. |
| AID206127 | In vitro antibacterial activity against ciprofloxacin-resistant Staphylococcus aureus (CRSA) C6043. | 1999 | Bioorganic & medicinal chemistry letters, Sep-20, Volume: 9, Issue:18 | Synthesis and in vitro activity of new oxazolidinone antibacterial agents having substituted isoxazoles. |
| AID524688 | Antibacterial activity against vancomycin-resistant Enterococcus faecium clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro antibacterial activity of CE-156811, a novel analog derived from hygromycin A. |
| AID524690 | Antibacterial activity against penicillin-nonsusceptible Streptococcus pneumoniae clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro antibacterial activity of CE-156811, a novel analog derived from hygromycin A. |
| AID576881 | Bactericidal activity against 48 hrs peripheral compartment culture samples of Enterococcus faecalis Ef1497 MutM3 in two-compartment pharmacokinetic/pharmacodynamic model assessed as effect on bacterial count at 600 mg, bid administered as 0.5 hr infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID1271221 | Ratio of AUC (0 to t) in brain to plasma in BALB/c mouse at 10 mg/kg, po | 2015 | ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11 | Design, Synthesis, and Identification of Silicon Incorporated Oxazolidinone Antibiotics with Improved Brain Exposure. |
| AID1862425 | Antibacterial activity against methicillin-resistant Staphylococcus aureus USA 300 (ARLG 1567) assessed as reduction in visible bacterial growth incubated for 18 to 20 hrs by CLSI based broth microdilution analysis | 2022 | European journal of medicinal chemistry, Oct-05, Volume: 240 | Membrane acting Povarov-Doebner derived compounds potently disperse preformed multidrug resistant Gram-positive bacterial biofilms. |
| AID1194837 | Antibacterial activity against Enterococcus faecalis incubated for 16 hrs by agar dilution method | 2015 | Bioorganic & medicinal chemistry letters, , Volume: 25, Issue:10 | Synthesis and structure-activity relationship studies of novel [6,6,5] tricyclic oxazolidinone derivatives as potential antibacterial agents. |
| AID278912 | Antibacterial activity against coagulase-negative staphylococci | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | In vitro antibacterial activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. |
| AID444265 | Antibacterial activity against Streptococcus pneumoniae ATCC 6303 by NCCLS method | 2009 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 19, Issue:22 | Synthesis and biological activity of novel oxazolidinones. |
| AID571766 | Antimicrobial activity against Escherichia coli K-12 3-AG300 harboring AcrB-615-628MexB-N616 mutant gene | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Site-directed mutagenesis reveals amino acid residues in the Escherichia coli RND efflux pump AcrB that confer macrolide resistance. |
| AID524971 | Antibacterial activity against vancomycin-resistant and teichoplanin-susceptible Enterococcus faecium clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Comparative surveillance study of telavancin activity against recently collected gram-positive clinical isolates from across the United States. |
| AID1853460 | Bactericidal activity against Enterococcus faecalis ATCC 29212 assessed as reduction in colony forming unit incubated for 20 hrs | 2021 | RSC medicinal chemistry, Nov-17, Volume: 12, Issue:11 | SF |
| AID548529 | Antimicrobial activity against Vancomycin-susceptible Enterococcus faecalis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Activities of dalbavancin against a worldwide collection of 81,673 gram-positive bacterial isolates. |
| AID1056356 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae SR11031 clinical isolate assessed as parasite growth inhibition by CLSI broth microdilution method | 2013 | ACS medicinal chemistry letters, Nov-14, Volume: 4, Issue:11 | Potent oxazolidinone antibacterials with heteroaromatic C-ring substructure. |
| AID528705 | Antibacterial activity against Streptococcus mitis clinical isolate assessed as susceptibility level by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID1250832 | Antibacterial activity against Staphylococcus aureus incubated for 18 hrs by agar dilution method | 2015 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 25, Issue:20 | Discovery of a potent enoyl-acyl carrier protein reductase (FabI) inhibitor suitable for antistaphylococcal agent. |
| AID1400056 | Bactericidal activity against Acinetobacter baumannii ATCC 19606 incubated for 24 hrs under aerobic condition by MABA | 2018 | Bioorganic & medicinal chemistry, 09-15, Volume: 26, Issue:17 | An antimycobacterial pleuromutilin analogue effective against dormant bacilli. |
| AID297131 | Antibacterial activity against Proteus mirabilis IFO3849 by agar plate dilution method | 2007 | Journal of medicinal chemistry, Aug-23, Volume: 50, Issue:17 | Discovery of 1,4-dihydroxy-2-naphthoate [corrected] prenyltransferase inhibitors: new drug leads for multidrug-resistant gram-positive pathogens. |
| AID560579 | Bactericidal activity against vancomycin-resistant Enterococcus faecium 1059060 expressing vanA gene assessed as change in bacterial count at 16 ug/ml by time-kill assay | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Impact of human serum albumin on oritavancin in vitro activity against enterococci. |
| AID534252 | Antimicrobial activity against linezolid-susceptible Staphylococcus aureus SA238 after 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Cellular pharmacodynamics of the novel biaryloxazolidinone radezolid: studies with infected phagocytic and nonphagocytic cells, using Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Legionella pneumophila. |
| AID1303404 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis after 24 hrs by microdilution method | 2016 | Bioorganic & medicinal chemistry letters, 07-01, Volume: 26, Issue:13 | Identification of novel aminopiperidine derivatives for antibacterial activity against Gram-positive bacteria. |
| AID1853462 | Bactericidal activity against vancomycin-resistant Enterococcus faecalis ATCC 700221 assessed as reduction in colony forming unit incubated for 20 hrs | 2021 | RSC medicinal chemistry, Nov-17, Volume: 12, Issue:11 | SF |
| AID534253 | Bacteriostatic activity against linezolid-susceptible Staphylococcus aureus SA238 after 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Cellular pharmacodynamics of the novel biaryloxazolidinone radezolid: studies with infected phagocytic and nonphagocytic cells, using Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Legionella pneumophila. |
| AID560523 | Antimicrobial activity against SCCmec type III vancomycin-intermediate Staphylococcus aureus isolate gs07022 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID405628 | AUC in human at 600 mg administered every 12 hrs measured after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Comparative study of the effects of pyridoxine, rifampin, and renal function on hematological adverse events induced by linezolid. |
| AID533968 | Antimicrobial activity against linezolid-susceptible Staphylococcus aureus ATCC 33591 infected in THP1 cells assessed as log reduction in bacterial count after 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Cellular pharmacodynamics of the novel biaryloxazolidinone radezolid: studies with infected phagocytic and nonphagocytic cells, using Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Legionella pneumophila. |
| AID1432977 | Inhibition of mitochondrial protein synthesis in rat H9c2 cells after 5 days by In-Cell ELISA | |||
| AID534508 | Drug level in human THP1 cells at 10 mg/L after 2 hrs in presence of 50 uM proton inophore monesin relative to control | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Cellular pharmacokinetics of the novel biaryloxazolidinone radezolid in phagocytic cells: studies with macrophages and polymorphonuclear neutrophils. |
| AID517667 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus HH1 by standard serial-dilution technique | 2010 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 20, Issue:20 | Bottromycin derivatives: efficient chemical modifications of the ester moiety and evaluation of anti-MRSA and anti-VRE activities. |
| AID562391 | Antimicrobial activity against oxacillin-susceptible Staphylococcus haemolyticus clinical isolates assessed as percent susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID562614 | Antimicrobial activity against methicillin-sensitive Staphylococcus aureus by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | In vitro activities of three new dihydrofolate reductase inhibitors against clinical isolates of gram-positive bacteria. |
| AID569348 | Antibacterial activity against Haemophilus influenzae by agar dilution method | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 | Design, synthesis and antibacterial activity of 3-methylenepyrrolidine formyl hydroxyamino derivatives as novel peptide deformylase inhibitors. |
| AID575101 | Antimicrobial activity against Streptococcus pneumoniae serotype 23B assessed as percent susceptible isolates by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID1361104 | Bacteriostatic activity against vancomycin-resistant Staphylococcus aureus VRS12 clinical isolate after 20 hrs by broth microdilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | N-(1,3,4-oxadiazol-2-yl)benzamide analogs, bacteriostatic agents against methicillin- and vancomycin-resistant bacteria. |
| AID456043 | Antibacterial activity against ciprofloxacin, methicillin-resistant Staphylococcus aureus after 18 hrs by twofold microbroth dilution method | 2009 | Bioorganic & medicinal chemistry, Oct-01, Volume: 17, Issue:19 | Design, synthesis and biological evaluations of novel 7-[3-(1-aminocycloalkyl)pyrrolidin-1-yl]-6-desfluoro-8-methoxyquinolones with potent antibacterial activity against multi-drug resistant Gram-positive bacteria. |
| AID1151721 | Bacteriostatic activity against vancomycin-sensitive Enterococcus | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID593963 | Antibacterial activity Staphylococcus epidermidis ATCC 12228 | 2011 | Bioorganic & medicinal chemistry letters, May-15, Volume: 21, Issue:10 | Synthesis and in vitro activity of novel 1,2,4-triazolo[4,3-a]pyrimidine oxazolidinone antibacterial agents. |
| AID1434675 | Anti-bacterial activity against methicillin-susceptible Staphylococcus aureus CCARM 0027 by 2-fold microtiter broth dilution method | 2017 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 27, Issue:3 | Cadiolides J-M, antibacterial polyphenyl butenolides from the Korean tunicate Pseudodistoma antinboja. |
| AID585174 | Antibacterial activity against Mycobacterium smegmatis harboring 23S rRNA A2572U1 mutant after 24 generation times | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Mutations in 23S rRNA at the peptidyl transferase center and their relationship to linezolid binding and cross-resistance. |
| AID1873891 | Antibacterial activity against Staphylococcus aureus ATCC 29213 incubated for 16 to 20 hrs using 10^4 CFU/ml bacterial inoculum by broth microdilution method | 2022 | European journal of medicinal chemistry, Aug-05, Volume: 238 | Design, synthesis and activity against drug-resistant bacteria evaluation of C-20, C-23 modified 5-O-mycaminosyltylonolide derivatives. |
| AID207016 | Antibacterial activity against methicillin - resistant Staphylococcus aureus (MRSA OC2878) | 2001 | Bioorganic & medicinal chemistry letters, Jul-23, Volume: 11, Issue:14 | Novel piperidinyloxy oxazolidinone antimicrobial agents. |
| AID522895 | Antibacterial activity against vancomycin-intermediate Staphylococcus aureus isolate 1012 after 24 hrs by modified broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Antistaphylococcal activity of ACHN-490 tested alone and in combination with other agents by time-kill assay. |
| AID541089 | Antibacterial activity against 1 x10'6 to 5 x10'6 CFU/ml methicillin-resistant Staphylococcus aureus ATCC 43300 assessed as effect on bacterial count at MIC after 24 hrs by time kill study | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Linezolid alone or combined with rifampin against methicillin-resistant Staphylococcus aureus in experimental foreign-body infection. |
| AID410104 | Antimicrobial activity against mef (A) expressing Streptococcus pneumoniae 02J1175 by NCCLS method | 2008 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 18, Issue:23 | Design at the atomic level: design of biaryloxazolidinones as potent orally active antibiotics. |
| AID571829 | Antibacterial activity against Propionibacterium propionicus by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID1770343 | Antibacterial activity against penicillin-susceptible Escherichia coli ATCC 25922 assessed as inhibition of bacterial growth measured after 20 hrs by two-fold microdilution assay | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Modification of 5-methylphenanthridium from benzothiazoles to indoles as potent FtsZ inhibitors: Broadening the antibacterial spectrum toward vancomycin-resistant enterococci. |
| AID542907 | Antimicrobial activity against Bacillus anthracis infected in in vitro hollow fiber PK/PD model assessed as bacterial regrowth at 600 mg administered once every 24 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID1076826 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 assessed as growth inhibition after 18 hrs by broth microdilution method | 2014 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 24, Issue:6 | Discovery of novel bis-oxazolidinone compounds as potential potent and selective antitubercular agents. |
| AID1168009 | Antibacterial activity against vancomycin-resistant Enterococcus faecium clinical isolate 14643 after overnight incubation by two-fold serial dilution method | 2014 | Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21 | Synthesis and biological evaluation of novel peptide BF2 as an antibacterial agent against clinical isolates of vancomycin-resistant enterococci. |
| AID284982 | Antimicrobial activity against Enterococcus avium at 0.25 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID467839 | Antibacterial activity against Enterococcus faecalis MTCC 439 after 24 hrs by agar dilution method | 2009 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 19, Issue:23 | Novel 4-N-substituted aryl but-3-ene-1,2-dione derivatives of piperazinyloxazolidinones as antibacterial agents. |
| AID297129 | Antibacterial activity against Escherichia coli NIHJ JC2 by agar plate dilution method | 2007 | Journal of medicinal chemistry, Aug-23, Volume: 50, Issue:17 | Discovery of 1,4-dihydroxy-2-naphthoate [corrected] prenyltransferase inhibitors: new drug leads for multidrug-resistant gram-positive pathogens. |
| AID1465594 | Antimicrobial activity against Mycobacterium tuberculosis H37Rv infected in C57BL/6J mouse assessed as bacterial load in lungs at 100 mg/kg qd administered for 8 consecutive weeks starting from 6 weeks post infection measured 24 hrs post last dose (Rvb = | 2017 | Journal of medicinal chemistry, 10-12, Volume: 60, Issue:19 | Discovery of a Potent and Specific M. tuberculosis Leucyl-tRNA Synthetase Inhibitor: (S)-3-(Aminomethyl)-4-chloro-7-(2-hydroxyethoxy)benzo[c][1,2]oxaborol-1(3H)-ol (GSK656). |
| AID558473 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus 525 measured on day 5 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID548532 | Antimicrobial activity against Vancomycin-nonsusceptible Enterococcus faecium by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Activities of dalbavancin against a worldwide collection of 81,673 gram-positive bacterial isolates. |
| AID574065 | Cmax in CF-1 mouse at 10 mg/kg, po | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | In vivo activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. |
| AID284971 | Antimicrobial activity against Corynebacterium pseudodiphtheriticum at <= 0.06 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID1852683 | Antibacterial activity against efflux pump lacking/recombinant OM pore producing Escherichia coli assessed as inhibition of bacterial growth | |||
| AID285033 | Antimicrobial activity against Rothia mucilaginosa at 0.5 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID1327121 | Antitubercular activity against dormant stage Mycobacterium bovis BCG ATCC 35734 at 10 ug/ml measured after 12 days by nitrate reductase assay | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Design, synthesis and biological evaluation of novel azaspiro analogs of linezolid as antibacterial and antitubercular agents. |
| AID541047 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 infected in Albino guiena pig assessed as decrease in planktonic bacterial counts in cage fluid at 50 mg/kg measured on day 4 postinfection | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Linezolid alone or combined with rifampin against methicillin-resistant Staphylococcus aureus in experimental foreign-body infection. |
| AID1271229 | Antibacterial activity against clinical isolate Neisseria meningitidis 306 by microbroth dilution method | 2015 | ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11 | Design, Synthesis, and Identification of Silicon Incorporated Oxazolidinone Antibiotics with Improved Brain Exposure. |
| AID1395710 | Bactericidal activity against vancomycin-resistant Staphylococcus aureus VRS10 incubated fo 18 hrs followed by re-plating on tryptic soy agar plates at 37 degC for 18 hrs by broth microdilution assay | 2018 | European journal of medicinal chemistry, May-10, Volume: 151 | Phenylthiazoles with tert-Butyl side chain: Metabolically stable with anti-biofilm activity. |
| AID1547706 | Antibacterial activity against Staphylococcus aureus NRS100 (COL) by broth microdilution method | 2020 | ACS medicinal chemistry letters, Mar-12, Volume: 11, Issue:3 | Structure-Activity Relationship for the Oxadiazole Class of Antibacterials. |
| AID1677786 | Inhibition of ftsZ in Bacillus subtilis assessed as increase in enzyme polymerization kinetics at 10 ug/ml measured for 30 mins by microtiter plate-based light scattering assay | 2020 | Bioorganic & medicinal chemistry, 11-01, Volume: 28, Issue:21 | Design, synthesis of novel 4,5-dihydroisoxazole-containing benzamide derivatives as highly potent FtsZ inhibitors capable of killing a variety of MDR Staphylococcus aureus. |
| AID1241207 | Inhibition of pre-miR-373 (unknown origin) cleavage assessed as reduction of oncogenic microRNAs biogenesis by measuring fluorescence every minute for 5 hrs using 5'-FAM,3'-dabcyl-pre-miRNA beacons by FRET assay in presence of recombinant Dicer | 2015 | Bioorganic & medicinal chemistry, Sep-01, Volume: 23, Issue:17 | Ribosome-targeting antibiotics as inhibitors of oncogenic microRNAs biogenesis: Old scaffolds for new perspectives in RNA targeting. |
| AID520227 | Antimicrobial activity against methicillin resistant Staphylococcus aureus 67-0 | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID560811 | Apparent volume of distribution with respect to the bioavailability in human adults with pulmonary tuberculosis at 600 mg administered twice daily for 7 days | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Population pharmacokinetics of linezolid in adults with pulmonary tuberculosis. |
| AID575946 | Antimicrobial activity against erythromycin-resistant Streptococcus pneumoniae assessed as susceptible isolates by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Distribution of serotypes, genotypes, and resistance determinants among macrolide-resistant Streptococcus pneumoniae isolates. |
| AID245199 | Minimum inhibitory concentration against Streptococcus pyogenes ATCC 49399; value ranges from 1.5-3 uM | 2004 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 14, Issue:22 | Aryl urea analogs with broad-spectrum antibacterial activity. |
| AID285124 | Antimicrobial activity against viridans group Streptococcus salivarius at <= 0.06 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID1574850 | Inhibition of recombinant human full length N-terminal FLAG-tagged MAO-A expressed in sf9 cells at 30 uM preincubated for 15 mins followed by substrate addition and measured after 60 mins by luminescence assay relative to control | 2019 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 29, Issue:3 | Design and synthesis of biaryloxazolidinone derivatives containing a rhodanine or thiohydantoin moiety as novel antibacterial agents against Gram-positive bacteria. |
| AID559369 | Antimicrobial activity against compound-susceptible Coxiella burnetii isolate CP2 obtained from patient with acute Q fever infected in african green monkey Vero cells after 24 hrs by shell vial assay | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Bacteriostatic and bactericidal activities of tigecycline against Coxiella burnetii and comparison with those of six other antibiotics. |
| AID285079 | Antimicrobial activity against viridans group Streptococcus bovis at 0.25 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID348602 | Antibacterial activity against methicillin-resistant Staphylococcus aureus 1 after 18 to 20 hrs by agar dilution method | 2008 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 18, Issue:21 | Synthesis and antibacterial activities of novel oxazolidinones having cyclic sulfonamide moieties. |
| AID483192 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus ATCC 29213 by microbroth dilution technique | 2010 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 20, Issue:12 | Design, synthesis, and antibacterial activity of 2,5-dihydropyrrole formyl hydroxyamino derivatives as novel peptide deformylase inhibitors. |
| AID348599 | Antibacterial activity against Streptococcus pyogenes ATCC 8736 after 18 to 20 hrs by agar dilution method | 2008 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 18, Issue:21 | Synthesis and antibacterial activities of novel oxazolidinones having cyclic sulfonamide moieties. |
| AID763980 | Antibacterial activity against Haemophilus influenzae ATCC 49247 after 18 hrs by NCCLS agar dilution method | 2013 | European journal of medicinal chemistry, Aug, Volume: 66 | Synthesis and antibacterial activities of N-substituted-glycinyl 1H-1,2,3-triazolyl oxazolidinones. |
| AID533004 | Antibacterial activity against vancomycin-intermediate Staphylococcus aureus IL phenotypic revertant after 24 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Improved antimicrobial activity of linezolid against vancomycin-intermediate Staphylococcus aureus. |
| AID555320 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 after 50 passages by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Antistaphylococcal activity of dihydrophthalazine antifolates, a family of novel antibacterial drugs. |
| AID1651639 | Antibacterial activity against Staphylococcus aureus NCTC 8325 assessed as reduction in microbial growth | 2020 | Journal of natural products, 03-27, Volume: 83, Issue:3 | Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019. |
| AID373837 | Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus 504 after 16 passages with quinupristin-dalfopristin measured after 10 times antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID429431 | Antibacterial activity against Escherichia coli ATCC 25922 by agar dilution method | 2009 | European journal of medicinal chemistry, Aug, Volume: 44, Issue:8 | Synthesis and antibacterial activity of novel 5-(4-methyl-1H-1,2,3-triazole) methyl oxazolidinones. |
| AID520480 | Antimicrobial activity against Staphylococcus aureus 168-1 isolated from osteomyelitis patient by broth macrodilution method | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Efficacies of ceftobiprole medocaril and comparators in a rabbit model of osteomyelitis due to methicillin-resistant Staphylococcus aureus. |
| AID1680073 | Antibacterial activity against methicillin-resistant Staphylococcus aureus assessed as inhibition of bacterial growth incubated for 16 to 20 hrs by CLSI-based broth microdilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Synthesis and antibacterial bioactivities of cationic deacetyl linezolid amphiphiles. |
| AID404935 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus isolate by CLSI dilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro activities of CG400549, a novel FabI inhibitor, against recently isolated clinical staphylococcal strains in Korea. |
| AID522823 | Antibacterial activity against vancomycin-resistant Staphylococcus aureus after 24 hrs by modified broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Antistaphylococcal activity of ACHN-490 tested alone and in combination with other agents by time-kill assay. |
| AID541077 | Cmin in cage fluid of Albino guiena pig at 75 mg/kg, ip after 12 hrs | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Linezolid alone or combined with rifampin against methicillin-resistant Staphylococcus aureus in experimental foreign-body infection. |
| AID535253 | Antimicrobial activity against vancomycin resistant Staphylococcus aureus VRS-1 expressing SCCmec type 2 element by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | In vitro activity of ceftaroline against community-associated methicillin-resistant, vancomycin-intermediate, vancomycin-resistant, and daptomycin-nonsusceptible Staphylococcus aureus isolates. |
| AID533972 | Antimicrobial activity against linezolid-susceptible Staphylococcus aureus SA238 infected in THP1 cells assessed as log reduction in bacterial count after 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Cellular pharmacodynamics of the novel biaryloxazolidinone radezolid: studies with infected phagocytic and nonphagocytic cells, using Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Legionella pneumophila. |
| AID125127 | In vivo antibacterial activity against Staphylococcus aureus after intramuscular administration (5 mg/kg) in mice using (MTT) mouse thigh test | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | New classes of antibacterial oxazolidinones with C-5, methylene O-linked heterocyclic side chains. |
| AID519988 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus nosocomial isolate | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID528838 | Antimicrobial activity against vancomycin-resistant Enterococcus sp. assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID534795 | Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | In vitro activity of ceftaroline against community-associated methicillin-resistant, vancomycin-intermediate, vancomycin-resistant, and daptomycin-nonsusceptible Staphylococcus aureus isolates. |
| AID560372 | Antimicrobial activity against vancomycin-resistant Enterococcus faecium 1119175 by broth dilution method in presence of 4% HSA | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Impact of human serum albumin on oritavancin in vitro activity against enterococci. |
| AID555299 | Antibacterial activity against Tmp-resistant coagulase-negative Staphylococcus aureus by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Antistaphylococcal activity of dihydrophthalazine antifolates, a family of novel antibacterial drugs. |
| AID83650 | Inhibitory activity against Haemophilus influenzae | 1996 | Journal of medicinal chemistry, Sep-27, Volume: 39, Issue:20 | New directions in antibacterial research. |
| AID1361124 | Bacteriostatic activity against AcrAB-tolC deficient Escherichia coli JW5503-1 after 20 hrs by broth microdilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | N-(1,3,4-oxadiazol-2-yl)benzamide analogs, bacteriostatic agents against methicillin- and vancomycin-resistant bacteria. |
| AID1609280 | Bactericidal activity against Staphylococcus aureus ATCC BAA42 incubated for 18 to 20 hrs followed by replating on tryptic soy agar plate and further incubated for 18 to 24 hrs by CLSI-based broth microdilution assay | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Phenylthiazoles with nitrogenous side chain: An approach to overcome molecular obesity. |
| AID292900 | Antimicrobial activity against Haemophilus influenzae by broth dilution method | 2007 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 17, Issue:2 | New carbon-linked azole oxazolidinones with improved potency and pharmacokinetics. |
| AID1079937 | Severe hepatitis, defined as possibly life-threatening liver failure or through clinical observations. Value is number of references indexed. [column 'MASS' in source] | |||
| AID68560 | Minimum inhibitory concentration against vancomycin resistant Enterococcus faecium OC 3312 | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | Synthesis and antibacterial activity of pyrroloaryl-substituted oxazolidinones. |
| AID1852665 | Antibacterial activity against multidrug resistant Klebsiella aerogenes ATCC43816 assessed as inhibition of bacterial growth incubated for 24 hrs in MHI medium by twofold serial dilution method | |||
| AID1151622 | Toxicity in female rat assessed as effect on RBC count at 100 mg/kg/day, po bid administered for 4 weeks (Rvb = 7.28 x 10'12/L) | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID424420 | Antibacterial activity against vancomycin-resistant Staphylococcus aureus HIP14300 isolated from patients foot wound by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Vancomycin-resistant Staphylococcus aureus isolates associated with Inc18-like vanA plasmids in Michigan. |
| AID27799 | Volume distribution in Male Sprague-Dawley Rat (25 mg/kg po); NC denotes not calculated | 2003 | Journal of medicinal chemistry, Jan-16, Volume: 46, Issue:2 | Identification of phenylisoxazolines as novel and viable antibacterial agents active against Gram-positive pathogens. |
| AID275450 | Antibacterial activity against methicillin-resistant Staphylococcus aureus | 2007 | Journal of medicinal chemistry, Jan-25, Volume: 50, Issue:2 | Isothiazoloquinolones with enhanced antistaphylococcal activities against multidrug-resistant strains: effects of structural modifications at the 6-, 7-, and 8-positions. |
| AID520014 | Antimicrobial activity against Staphylococcus aureus A8727 | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID284943 | Antimicrobial activity against Aerococcus spp. at 1 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID519073 | Antimicrobial activity against wild type Staphylococcus aureus RN4220 measured after 21 days of subculturing by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Linezolid and tiamulin cross-resistance in Staphylococcus aureus mediated by point mutations in the peptidyl transferase center. |
| AID1056336 | Inhibition of human CYP3A4 assessed as terfenadine hydroxylation after 20 mins by LC-MS/MS analysis | 2013 | ACS medicinal chemistry letters, Nov-14, Volume: 4, Issue:11 | Potent oxazolidinone antibacterials with heteroaromatic C-ring substructure. |
| AID562159 | Antimicrobial activity against heterogeneous vancomycin-intermediate Staphylococcus aureus 873 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID533928 | Antimicrobial activity against linezolid-resistant Staphylococcus aureus 1652 harboring U2500A mutation in peptidyl transferase centre by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains. |
| AID561263 | Antibacterial activity against Enterococcus faecalis assessed as intermediate isolates by CLSI M100-S17 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | AFN-1252, a FabI inhibitor, demonstrates a Staphylococcus-specific spectrum of activity. |
| AID571819 | Antibacterial activity against Bifidobacterium dentium by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID1591539 | Antibacterial activity against Bacillus pumilus CMCC63202 incubated for 24 hrs by CLSI protocol based broth microdilution method | 2019 | Bioorganic & medicinal chemistry, 07-15, Volume: 27, Issue:14 | Discovery of 1,3,4-oxadiazol-2-one-containing benzamide derivatives targeting FtsZ as highly potent agents of killing a variety of MDR bacteria strains. |
| AID1174905 | Antibacterial activity against methicillin-resistant Staphylococcus aureus MRSA 433 by broth microdilution method | 2014 | Bioorganic & medicinal chemistry, Dec-15, Volume: 22, Issue:24 | New potent antibacterials against Gram-positive multiresistant pathogens: effects of side chain modification and chirality in linezolid-like 1,2,4-oxadiazoles. |
| AID561265 | Antibacterial activity against Enterococcus faecium by CLSI M100-S17 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | AFN-1252, a FabI inhibitor, demonstrates a Staphylococcus-specific spectrum of activity. |
| AID566573 | Antimicrobial activity against Micrococcus luteus ATCC 9341 by conventional agar-dilution method | 2011 | European journal of medicinal chemistry, Jan, Volume: 46, Issue:1 | Discovery of a novel nitroimidazolyl-oxazolidinone hybrid with potent anti Gram-positive activity: Synthesis and antibacterial evaluation. |
| AID11315 | Steady state volume distribution (Vss) of compound (10 mg/kg) after iv administration was determined in Sprague-Dawley rat | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | The effect of remote chirality on the antibacterial activity of indolinyl, tetrahydroquinolyl and dihydrobenzoxazinyl oxazolidinones. |
| AID569338 | Antibacterial activity against Staphylococcus aureus ATCC 25923 by broth micro dilution technique | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 | Design, synthesis and antibacterial activity of 3-methylenepyrrolidine formyl hydroxyamino derivatives as novel peptide deformylase inhibitors. |
| AID1853453 | Antibacterial activity against Enterococcus faecalis ATCC 29212 assessed as bacterial growth inhibition incubated for 18 to 20 hrs by CLSI based broth microdilution assay | 2021 | RSC medicinal chemistry, Nov-17, Volume: 12, Issue:11 | SF |
| AID562596 | Antimicrobial activity against Enterococcus faecalis clinical isolates assessed as resistant isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID560505 | Antimicrobial activity against SCCmec type II vancomycin-intermediate Staphylococcus aureus isolate b2k4781 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID318357 | Antibacterial activity against macrolide-resistant Enterococcus faecalis | 2007 | Proceedings of the National Academy of Sciences of the United States of America, May-01, Volume: 104, Issue:18 | Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties. |
| AID1547713 | Antibacterial activity against Bacillus cereus ATCC 13061 by broth microdilution method | 2020 | ACS medicinal chemistry letters, Mar-12, Volume: 11, Issue:3 | Structure-Activity Relationship for the Oxadiazole Class of Antibacterials. |
| AID387452 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis DRCC 153 | 2008 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 18, Issue:18 | Novel and potent oxazolidinone antibacterials featuring 3-indolylglyoxamide substituents. |
| AID410229 | Antibacterial activity against Klebsiella pneumoniae at 128 ug/mL by broth micro dilution method | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24 | A facile synthesis, antibacterial, and antitubercular studies of some piperidin-4-one and tetrahydropyridine derivatives. |
| AID134113 | Protective dose of orally administered compound against intraperitoneally-induced septicaemia model ( vancomycin resistant Enterococci faecium D3HT12 strain) in murine | 2000 | Bioorganic & medicinal chemistry letters, Aug-07, Volume: 10, Issue:15 | Improved antibacterial activities of coumarin antibiotics bearing 5',5'-dialkylnoviose: biological activity of RU79115. |
| AID285030 | Antimicrobial activity against Rothia mucilaginosa at <= 0.06 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID68390 | In vitro antibacterial activity against vancomycin-resistant Enterococcus faecium 2006 (VRE.2) | 2003 | Bioorganic & medicinal chemistry letters, Nov-17, Volume: 13, Issue:22 | Synthesis and in vitro activity of novel isoxazolyl tetrahydropyridinyl oxazolidinone antibacterial agents. |
| AID284944 | Antimicrobial activity against Aerococcus spp. at 2 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID525137 | Antibacterial activity against Staphylococcus aureus EMRSA-15 after 18 to 24 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Delayed development of linezolid resistance in Staphylococcus aureus following exposure to low levels of antimicrobial agents. |
| AID562398 | Antimicrobial activity against Staphylococcus aureus clinical isolates assessed as percent susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID1056360 | Antibacterial activity against Enterococcus faecalis SR1004 clinical isolate assessed as parasite growth inhibition by CLSI broth microdilution method | 2013 | ACS medicinal chemistry letters, Nov-14, Volume: 4, Issue:11 | Potent oxazolidinone antibacterials with heteroaromatic C-ring substructure. |
| AID532793 | Antibacterial activity against vancomycin-intermediate Staphylococcus aureus 99/3759-V after 24 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Improved antimicrobial activity of linezolid against vancomycin-intermediate Staphylococcus aureus. |
| AID583889 | Antibacterial activity against hospital-associated methicillin-resistant Staphylococcus aureus isolate 360 by broth microdilution assay | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Comparative efficacies of human simulated exposures of telavancin and vancomycin against methicillin-resistant Staphylococcus aureus with a range of vancomycin MICs in a murine pneumonia model. |
| AID523044 | Antimicrobial activity against Corynebacterium jeikeium by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative in vitro antimicrobial activities of torezolid (TR-700), the active moiety of a new oxazolidinone, torezolid phosphate (TR-701), determination of tentative disk diffusion interpretive criteria, and quality control ranges. |
| AID573873 | Antibacterial activity against community-associated methicillin-resistant Staphylococcus aureus OC8525 infected in iv dosed Swiss Webster mouse administered at 1 to 3 hrs post infection measured after 3 days | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | In vivo activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. |
| AID1167998 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis clinical isolate 22/203 after overnight incubation by two-fold serial dilution method | 2014 | Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21 | Synthesis and biological evaluation of novel peptide BF2 as an antibacterial agent against clinical isolates of vancomycin-resistant enterococci. |
| AID1197160 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 27660 in po dosed ICR mouse peritonitis infection model assessed as survival rate administered at 1 hr post infection | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3 | Structure-activity relationship for the oxadiazole class of antibiotics. |
| AID559279 | Antimicrobial activity against Enterococcus faecalis JH2-2 harboring nucleotides at position 2576 in rrlA 2576G, rrlB 2576G, rrlC 2576G and rrlD 2576G by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Influence of recombination on development of mutational resistance to linezolid in Enterococcus faecalis JH2-2. |
| AID560817 | Antimicrobial activity against Mycobacterium tuberculosis in human adults with pulmonary tuberculosis at 600 mg administered daily for 7 days | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Population pharmacokinetics of linezolid in adults with pulmonary tuberculosis. |
| AID542891 | fCmax in Bacillus anthracis infected in vitro hollow fiber PK/PD model at simulated dose of 500 mg administered every 12 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID561341 | Antibacterial activity against Methicillin-resistant Staphylococcus aureus by CLSI broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Potency and bactericidal activity of iclaprim against recent clinical gram-positive isolates. |
| AID1852688 | Antibacterial activity against efflux pump lacking/recombinant OM pore producing Acinetobacter baumannii incubated for 24 hrs by twofold serial dilution method | |||
| AID511385 | Antibacterial activity against vancomycin resistant Enterococcus faecium by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Comparative in vitro activities of nemonoxacin (TG-873870), a novel nonfluorinated quinolone, and other quinolones against clinical isolates. |
| AID348594 | Antibacterial activity against Staphylococcus aureus C463 after 18 to 20 hrs by agar dilution method | 2008 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 18, Issue:21 | Synthesis and antibacterial activities of novel oxazolidinones having cyclic sulfonamide moieties. |
| AID571820 | Antibacterial activity against Bifidobacterium infantis by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID1591561 | Bactericidal activity against Staphylococcus aureus ATCC 43300 assessed as 3 log reduction in number of colony forming units incubated for 24 hrs followed by aliquots transfer to tryptic soy agar and grown for 24 hrs | 2019 | Bioorganic & medicinal chemistry, 07-15, Volume: 27, Issue:14 | Discovery of 1,3,4-oxadiazol-2-one-containing benzamide derivatives targeting FtsZ as highly potent agents of killing a variety of MDR bacteria strains. |
| AID206451 | In vitro antibacterial activity against methicillin-susceptible Staphylococcus aureus (MSSA) C2214. | 1999 | Bioorganic & medicinal chemistry letters, Sep-20, Volume: 9, Issue:18 | Synthesis and in vitro activity of new oxazolidinone antibacterial agents having substituted isoxazoles. |
| AID523791 | Antimicrobial activity against oxacillin-resistant Staphylococcus aureus assessed as inhibition of microbial growth at 1 ug/ml by CLSI method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative activities of TR-700 (torezolid) against staphylococcal blood isolates collected in Spain. |
| AID197767 | Compound was evaluated for metabolic stability via In vitro Rat 5E6 cell at 50 uM concentration | 2003 | Journal of medicinal chemistry, Jan-16, Volume: 46, Issue:2 | Identification of phenylisoxazolines as novel and viable antibacterial agents active against Gram-positive pathogens. |
| AID519487 | Antibacterial activity against Staphylococcus aureus T1900 expressing 23S rrn3 G2576T, rrn4 G2576T and rrn5 G2576T mutants by Etest method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Linezolid resistance in Staphylococcus aureus: gene dosage effect, stability, fitness costs, and cross-resistances. |
| AID1412976 | Antibacterial activity against methicillin-resistant Staphylococcus aureus after 16 hrs by agar dilution method | 2018 | MedChemComm, May-01, Volume: 9, Issue:5 | The semi-synthesis, biological evaluation and docking analysis of the oxime, hydrazine and hydrazide derivatives of platensimycin. |
| AID284955 | Antimicrobial activity against Bacillus cereus at 1 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID326511 | Tmax in Enterococcus faecalis infected Wistar rat at 600 mg, po four consecutive administration every 12 hrs | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Single-dose oral amoxicillin or linezolid for prophylaxis of experimental endocarditis due to vancomycin-susceptible and vancomycin-resistant Enterococcus faecalis. |
| AID560500 | Antimicrobial activity against SCCmec type II vancomycin-intermediate Staphylococcus aureus isolate sh06024 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID565008 | Antimicrobial activity against methicillin-susceptible coagulase-negative Staphylococcus haemolyticus after 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID533665 | Antimicrobial activity against Staphylococcus aureus ATCC 29213 | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic characterization of Vga ABC proteins conferring reduced susceptibility to pleuromutilins in Staphylococcus aureus. |
| AID284990 | Antimicrobial activity against Enterococcus casseliflavus at 0.5 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID576877 | Bactericidal activity against 12.5 hrs peripheral compartment culture samples of Enterococcus faecalis Ef1497 MutM3 in two-compartment pharmacokinetic/pharmacodynamic model assessed as effect on bacterial count at 600 mg, bid administered as 0.5 hr infusi | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID340859 | Antimicrobial activity against vancomycin-intermediate resistant Staphylococcus aureus Mu50 graR mutant microdilution assay | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Interaction of the GraRS two-component system with the VraFG ABC transporter to support vancomycin-intermediate resistance in Staphylococcus aureus. |
| AID1117374 | Antimicrobial activity against Staphylococcus aureus Efs1 assessed as inhibition zone at 37 degC for 24 hrs by agar diffusion method | 2010 | MedChemComm, Aug-01, Volume: 1, Issue:2 | Syntheses and biological evaluation of new cephalosporin-oxazolidinone conjugates. |
| AID27809 | Cmax value in Male Sprague-Dawley Rat at dose 10 (mg/kg iv); ND denotes not reported | 2003 | Journal of medicinal chemistry, Jan-16, Volume: 46, Issue:2 | Identification of phenylisoxazolines as novel and viable antibacterial agents active against Gram-positive pathogens. |
| AID524952 | Antibacterial activity against methicillin-susceptible coagulase-negative Staphylococcus warneri clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Comparative surveillance study of telavancin activity against recently collected gram-positive clinical isolates from across the United States. |
| AID326281 | Antibacterial activity against methicillin-resistant Staphylococcus aureus 4913 at 4 hrs daily exposure for 1 day by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Comparative activities of daptomycin, linezolid, and tigecycline against catheter-related methicillin-resistant Staphylococcus bacteremic isolates embedded in biofilm. |
| AID522912 | Antibacterial activity against hospital-acquired methicillin-resistant Staphylococcus aureus isolate 1776 after 24 hrs by modified broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Antistaphylococcal activity of ACHN-490 tested alone and in combination with other agents by time-kill assay. |
| AID1723494 | Antibacterial activity against Enterococcus faecium NR-32065 incubated for 18 to 20 hrs under aerobic condition by CLSI protocol based broth microdilution assay | |||
| AID173097 | Cmax was evaluated in male Dawley rats at a dose of 25 mg/kg when taken perorally | 1998 | Journal of medicinal chemistry, Dec-17, Volume: 41, Issue:26 | Nitrogen-carbon-linked (azolylphenyl)oxazolidinones with potent antibacterial activity against the fastidious gram-negative organisms Haemophilus influenzae and Moraxella catarrhalis. |
| AID533005 | Antibacterial activity against vancomycin-intermediate Staphylococcus aureus AMC11094 phenotypic revertant after 24 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Improved antimicrobial activity of linezolid against vancomycin-intermediate Staphylococcus aureus. |
| AID533933 | Antimicrobial activity against linezolid-resistant methicillin-resistant Staphylococcus aureus NRS271 harboring G2576U mutation in peptidyl transferase centre by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains. |
| AID1578412 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus NRS119 by broth liquid microdilution method | 2020 | European journal of medicinal chemistry, Jan-01, Volume: 185 | Modifying the lipophilic part of phenylthiazole antibiotics to control their drug-likeness. |
| AID1594070 | Antibacterial activity against methicillin-resistant Staphylococcus aureus assessed as reduction in bacterial cell viability incubated for 20 to 24 hrs by REMA method | 2019 | Bioorganic & medicinal chemistry, 06-15, Volume: 27, Issue:12 | Design, synthesis, in-silico studies and biological screening of quinazolinone analogues as potential antibacterial agents against MRSA. |
| AID284998 | Antimicrobial activity against Enterococcus durans at 1 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID1337726 | Antibacterial activity against Staphylococcus aureus clinical isolate after 18 to 24 hrs by broth microdilution method | 2016 | European journal of medicinal chemistry, Nov-29, Volume: 124 | New isoxazolidinone and 3,4-dehydro-β-proline derivatives as antibacterial agents and MAO-inhibitors: A complex balance between two activities. |
| AID369445 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae after 20 to 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vitro activity of telavancin against gram-positive clinical isolates recently obtained in Europe. |
| AID753132 | Antitubercular activity against Mycobacterium tuberculosis H37Rv assessed as growth inhibition after 2 to 3 weeks by broth microdilution method | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | Anti-tubercular agents. Part 7: a new class of diarylpyrrole-oxazolidinone conjugates as antimycobacterial agents. |
| AID1770357 | Bactericidal activity against methicillin-resistant Staphylococcus aureus ATCC43300 assessed as inhibition of bacterial growth measured after 20 hrs by two-fold microdilution assay | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Modification of 5-methylphenanthridium from benzothiazoles to indoles as potent FtsZ inhibitors: Broadening the antibacterial spectrum toward vancomycin-resistant enterococci. |
| AID244841 | Minimum inhibitory concentration against Escherichia coli ATCC 25922 | 2004 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 14, Issue:22 | Aryl urea analogs with broad-spectrum antibacterial activity. |
| AID528967 | Antimicrobial activity against methicillin-susceptible Staphylococcus epidermidis isolated from ICU patient blood assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID1680058 | Antibacterial activity against methicillin-resistant Staphylococcus aureus clinical isolate 7 assessed as reduction in bacterial growth incubated for 16 to 20 hrs by CLSI-based broth microdilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Synthesis and antibacterial bioactivities of cationic deacetyl linezolid amphiphiles. |
| AID523808 | Antimicrobial activity against oxacillin-susceptible Staphylococcus aureus assessed as inhibition of microbial growth at 4 ug/ml by CLSI method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative activities of TR-700 (torezolid) against staphylococcal blood isolates collected in Spain. |
| AID533751 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus ATCC 25923 after 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Cellular pharmacodynamics of the novel biaryloxazolidinone radezolid: studies with infected phagocytic and nonphagocytic cells, using Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Legionella pneumophila. |
| AID565755 | Antimicrobial activity against Staphylococcus haemolyticus clinical isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID569339 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus ATCC 29213 by broth micro dilution technique | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 | Design, synthesis and antibacterial activity of 3-methylenepyrrolidine formyl hydroxyamino derivatives as novel peptide deformylase inhibitors. |
| AID566576 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus 17 by conventional agar-dilution method | 2011 | European journal of medicinal chemistry, Jan, Volume: 46, Issue:1 | Discovery of a novel nitroimidazolyl-oxazolidinone hybrid with potent anti Gram-positive activity: Synthesis and antibacterial evaluation. |
| AID583403 | Antimicrobial activity against vancomycin-resistant Staphylococcus aureus isolate MI assessed as bacterial count at 4 times MIC after 24 hrs by colony counting method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | In vitro activity of the new multivalent glycopeptide-cephalosporin antibiotic TD-1792 against vancomycin-nonsusceptible Staphylococcus isolates. |
| AID1904917 | Antibacterial activity against methicillin-resistant Staphylococcus aureus NRS 384 (USA300) incubated for 18 to 20 hrs by broth microdilution method | 2022 | European journal of medicinal chemistry, Apr-15, Volume: 234 | Exploring the structure-activity relationships of diphenylurea as an antibacterial scaffold active against methicillin- and vancomycin-resistant Staphylococcus aureus. |
| AID569344 | Antibacterial activity against methicillin-susceptible Staphylococcus epidermidis by agar dilution method | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 | Design, synthesis and antibacterial activity of 3-methylenepyrrolidine formyl hydroxyamino derivatives as novel peptide deformylase inhibitors. |
| AID1680039 | Antibacterial activity against NDM1 producing carbapenem-resistant Enterobacteriaceae clinical isolate 7 assessed as reduction in bacterial growth incubated for 16 to 20 hrs by CLSI-based broth microdilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Synthesis and antibacterial bioactivities of cationic deacetyl linezolid amphiphiles. |
| AID1168002 | Antibacterial activity against vancomycin-resistant Enterococcus faecium clinical isolate 17301 after overnight incubation by two-fold serial dilution method | 2014 | Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21 | Synthesis and biological evaluation of novel peptide BF2 as an antibacterial agent against clinical isolates of vancomycin-resistant enterococci. |
| AID1451759 | Antibacterial activity against Staphylococcus aureus Newman infected in BALB/c mouse assessed as reduction of bacterial burden in liver at 0.4 mg, ip bid for 4.5 days pretreated 24 hrs prior to bacterial infection measured 108 hrs post infection relative | 2017 | Journal of medicinal chemistry, 10-12, Volume: 60, Issue:19 | Novel Inhibitors of Staphyloxanthin Virulence Factor in Comparison with Linezolid and Vancomycin versus Methicillin-Resistant, Linezolid-Resistant, and Vancomycin-Intermediate Staphylococcus aureus Infections in Vivo. |
| AID292670 | Antibacterial activity against Streptococcus pneumoniae by broth microdilution method | 2007 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 17, Issue:18 | A distal methyl substituent attenuates mitochondrial protein synthesis inhibition in oxazolidinone antibacterials. |
| AID285034 | Antimicrobial activity against Rothia mucilaginosa at 1 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID370038 | Normalized AUC in Staphylococcus aureus-infected mouse localized thigh infection model at 25 mg/kg | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vivo efficacy of a novel oxazolidinone compound in two mouse models of infection. |
| AID1241211 | Binding affinity to 5'-FAM-pre-miR-373 (unknown origin) after 4 hrs by fluorescence assay | 2015 | Bioorganic & medicinal chemistry, Sep-01, Volume: 23, Issue:17 | Ribosome-targeting antibiotics as inhibitors of oncogenic microRNAs biogenesis: Old scaffolds for new perspectives in RNA targeting. |
| AID1760596 | Efflux ratio of MIC for Escherichia coli 25922 to MIC for Escherichia coli JW5503 | 2021 | European journal of medicinal chemistry, Feb-05, Volume: 211 | Installation of an aryl boronic acid function into the external section of N-aryl-oxazolidinones: Synthesis and antimicrobial evaluation. |
| AID53320 | Inhibitory activity against Escherichia coli DNA gyrase in supercoiling assay; Not tested | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | Structure-activity relationship in the oxazolidinone-quinolone hybrid series: influence of the central spacer on the antibacterial activity and the mode of action. |
| AID564813 | Bactericidal activity against methicillin-resistant coagulase-negative Staphylococcus epidermidis after 24 hrs by plate counting method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID574547 | Increase in PSMalpha levels in Staphylococcus aureus USA300 at subinhibitory concentrations after 24 hrs by RP-HPLC/ESI- MS | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Subinhibitory concentrations of protein synthesis-inhibiting antibiotics promote increased expression of the agr virulence regulator and production of phenol-soluble modulin cytolysins in community-associated methicillin-resistant Staphylococcus aureus. |
| AID285157 | Antimicrobial susceptibility of tetracycline-resistant Streptococcus pneumoniae from respiratory tract disease patient assessed as percent susceptible isolates | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Clonal diversity and resistance mechanisms in tetracycline-nonsusceptible Streptococcus pneumoniae isolates in Poland. |
| AID1596556 | Antibacterial activity against vancomycin resistant Enterococcus faecium ATCC 700221 assessed as reduction in bacterial cell growth incubated for 18 to 20 hrs by broth microdilution method | 2019 | European journal of medicinal chemistry, Aug-01, Volume: 175 | Lipophilic efficient phenylthiazoles with potent undecaprenyl pyrophosphatase inhibitory activity. |
| AID390341 | Antimicrobial activity against Pseudomonas aeruginosa 1473 | 2008 | Journal of natural products, Dec, Volume: 71, Issue:12 | Citreamicins with potent gram-positive activity. |
| AID562182 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus 540 after 36 passages by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID591662 | Antimicrobial activity against multidrug-resistant Enterococcus faecium after 18 hrs by agar dilution method | 2011 | Journal of medicinal chemistry, Apr-14, Volume: 54, Issue:7 | A new DNA gyrase inhibitor subclass of the cyclothialidine family based on a bicyclic dilactam-lactone scaffold. Synthesis and antibacterial properties. |
| AID630558 | Antibacterial activity against Enterococcus faecalis after 16 hrs by agar dilution method | 2011 | Journal of medicinal chemistry, Nov-10, Volume: 54, Issue:21 | Design, synthesis, and structure-activity relationship studies of highly potent novel benzoxazinyl-oxazolidinone antibacterial agents. |
| AID571768 | Antimicrobial activity against Escherichia coli K-12 3-AG300 harboring AcrB-I626M mutant gene | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Site-directed mutagenesis reveals amino acid residues in the Escherichia coli RND efflux pump AcrB that confer macrolide resistance. |
| AID373658 | Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus 555 Hershey by agar dilution CLSI method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID575102 | Antimicrobial activity against Streptococcus pneumoniae serotype 19F assessed as percent susceptible isolates by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID577129 | Terminal half-life in two-compartment pharmacokinetic/pharmacodynamic model at 800 mg, bid administered as 0.5 hr infusion over 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID1594376 | Antibacterial activity against Escherichia coli BW25113 after 18 to 24 hrs in presence of colistin by broth microdilution method | 2019 | Bioorganic & medicinal chemistry, 05-01, Volume: 27, Issue:9 | Second-generation aryl isonitrile compounds targeting multidrug-resistant Staphylococcus aureus. |
| AID284981 | Antimicrobial activity against Enterococcus avium at 0.12 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID1647977 | Cytotoxicity against human Caco2 cells by CCK8 assay | 2020 | Journal of natural products, 02-28, Volume: 83, Issue:2 | The Isolation of Pyrroloformamide Congeners and Characterization of Their Biosynthetic Gene Cluster. |
| AID1271207 | Solubility of compound at pH 10.2 by HPLC analysis | 2015 | ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11 | Design, Synthesis, and Identification of Silicon Incorporated Oxazolidinone Antibiotics with Improved Brain Exposure. |
| AID565751 | Antimicrobial activity against vancomycin-susceptible Enterococcus faecalis clinical isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID319983 | Antimicrobial activity against Staphylococcus aureus | 2008 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 18, Issue:2 | Synthesis, SAR, and antibacterial activity of novel oxazolidinone analogues possessing urea functionality. |
| AID1862428 | Antibacterial activity against methicillin-resistant Staphylococcus aureus USA 300 (ARLG 1570) assessed as reduction in visible bacterial growth incubated for 18 to 20 hrs by CLSI based broth microdilution analysis | 2022 | European journal of medicinal chemistry, Oct-05, Volume: 240 | Membrane acting Povarov-Doebner derived compounds potently disperse preformed multidrug resistant Gram-positive bacterial biofilms. |
| AID1649291 | Antibacterial activity against Streptococcus pneumoniae type 1 assessed as inhibition of bacterial growth incubated for 20 hrs by microdilution broth method | |||
| AID373656 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus 525 by agar dilution CLSI method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID1877885 | Antibacterial activity against methicillin-resistant and vancomycin-intermediate Staphylococcus aureus Mu50 assessed as bacterial growth inhibition | 2022 | Bioorganic & medicinal chemistry letters, 03-01, Volume: 59 | Novel 2,4-disubstituted quinazoline analogs as antibacterial agents with improved cytotoxicity profile: Modification of the benzenoid part. |
| AID285347 | Antibacterial activity against community acquired methicillin-resistant Staphylococcus aureus HT20010734 in CCY medium | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Effect of antibiotics on Staphylococcus aureus producing Panton-Valentine leukocidin. |
| AID516166 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus clinical isolates assessed as susceptible isolates by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | In vitro activity of telavancin against a contemporary worldwide collection of Staphylococcus aureus isolates. |
| AID548742 | Antimicrobial activity against Vancomycin-nonsusceptible Enterococcus faecalis assessed as percent susceptible isolate by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Activities of dalbavancin against a worldwide collection of 81,673 gram-positive bacterial isolates. |
| AID571812 | Antibacterial activity against Clostridium sporosphaeroides by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID717213 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus CCARM 3090 incubated for 24 hrs by microtiter broth dilution method | 2012 | Journal of natural products, Dec-28, Volume: 75, Issue:12 | Antibacterial butenolides from the Korean tunicate Pseudodistoma antinboja. |
| AID533935 | Antimicrobial activity against linezolid-resistant Staphylococcus aureus 004-737X harboring plasmid borne cfr gene by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains. |
| AID244880 | Minimal inhibitory concentration against Salmonella abony NCTC 6017 | 2004 | Bioorganic & medicinal chemistry letters, Sep-20, Volume: 14, Issue:18 | Synthesis and antibacterial activity of some aryloxy/thioaryloxy oxazolidinone derivatives. |
| AID404950 | Antibacterial activity against methicillin-susceptible coagulase-negative Staphylococcus sp. assessed as percent susceptible isolates by CLSI dilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro activities of CG400549, a novel FabI inhibitor, against recently isolated clinical staphylococcal strains in Korea. |
| AID206646 | Antibacterial activity against methicillin resistant Staphylococcus aureus (MRSA) | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | Iclaprim, a novel diaminopyrimidine with potent activity on trimethoprim sensitive and resistant bacteria. |
| AID1076827 | Antibacterial activity against Escherichia coli ATCC 25922 assessed as growth inhibition after 18 hrs by broth microdilution method | 2014 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 24, Issue:6 | Discovery of novel bis-oxazolidinone compounds as potential potent and selective antitubercular agents. |
| AID383570 | Antibacterial activity against multidrug-resistant Streptococcus pneumoniae ATCC 700904 by broth microdilution technique | 2008 | European journal of medicinal chemistry, Apr, Volume: 43, Issue:4 | Synthesis and in vitro antibacterial activities of novel oxazolidinones. |
| AID542881 | fCmax in Bacillus anthracis infected in vitro hollow fiber PK/PD model at simulated dose of 800 mg administered as 2 divided doses every 12 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID205743 | In vitro antibacterial activity against Staphylococcus epidermidis Q004 (S.e.1) | 2003 | Bioorganic & medicinal chemistry letters, Nov-17, Volume: 13, Issue:22 | Synthesis and in vitro activity of novel isoxazolyl tetrahydropyridinyl oxazolidinone antibacterial agents. |
| AID528691 | Antibacterial activity against Enterococcus faecalis ATCC 51575 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID429418 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus by agar dilution method | 2009 | European journal of medicinal chemistry, Aug, Volume: 44, Issue:8 | Synthesis and antibacterial activity of novel 5-(4-methyl-1H-1,2,3-triazole) methyl oxazolidinones. |
| AID244921 | Minimal inhibitory concentration against Serratia marcescens ATCC 12999 | 2004 | Bioorganic & medicinal chemistry letters, Sep-20, Volume: 14, Issue:18 | Synthesis and antibacterial activity of some aryloxy/thioaryloxy oxazolidinone derivatives. |
| AID387462 | Drug elimination in Swiss albino mouse at 10 mg/kg, po | 2008 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 18, Issue:18 | Novel and potent oxazolidinone antibacterials featuring 3-indolylglyoxamide substituents. |
| AID1514452 | Antitubercular activity against kanamycin-resistant Mycobacterium tuberculosis after 7 days by resazurin dye based colorimetric assay | 2019 | Bioorganic & medicinal chemistry letters, 01-01, Volume: 29, Issue:1 | Synthesis, antituberculosis studies and biological evaluation of new quinoline derivatives carrying 1,2,4-oxadiazole moiety. |
| AID1680046 | Antibacterial activity against carbapenem-resistant Klebsiella pneumoniae clinical isolate 10 assessed as reduction in bacterial growth incubated for 16 to 20 hrs by CLSI-based broth microdilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Synthesis and antibacterial bioactivities of cationic deacetyl linezolid amphiphiles. |
| AID292606 | Antimicrobial activity against Staphylococcus aureus 15187 by agar dilution method | 2007 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 17, Issue:17 | Synthesis and antibacterial activity of novel oxazolidinones with methylene oxygen- and methylene sulfur-linked substituents at C5-position. |
| AID348597 | Antibacterial activity against Enterococcus faecium C803 after 18 to 20 hrs by agar dilution method | 2008 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 18, Issue:21 | Synthesis and antibacterial activities of novel oxazolidinones having cyclic sulfonamide moieties. |
| AID645043 | Antibacterial activity against methicillin-resistant Staphylococcus aureus C530 after 16 to 20 hrs by microbroth dilution method | 2012 | European journal of medicinal chemistry, Apr, Volume: 50 | Synthesis and preliminary antibacterial evaluation of Linezolid-like 1,2,4-oxadiazole derivatives. |
| AID1168011 | Antibacterial activity against vancomycin-resistant Enterococcus faecium clinical isolate 31176 after overnight incubation by two-fold serial dilution method | 2014 | Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21 | Synthesis and biological evaluation of novel peptide BF2 as an antibacterial agent against clinical isolates of vancomycin-resistant enterococci. |
| AID558735 | Antimicrobial activity against vancomycin-resistant Staphylococcus aureus 510 measured on day 50 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID1414196 | Bactericidal activity against methicillin-resistant Staphylococcus aureus ATCC 43300 incubated for 24 hrs followed by plating onto tryptic soy agar plates and further incubated for 24 hrs by broth microdilution based CLSI method | 2018 | European journal of medicinal chemistry, Nov-05, Volume: 159 | Design, synthesis and structure-based optimization of novel isoxazole-containing benzamide derivatives as FtsZ modulators. |
| AID533393 | Antimicrobial activity against Clostridium innocuum by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activities of doripenem, a new broad-spectrum carbapenem, against recently collected clinical anaerobic isolates, with emphasis on the Bacteroides fragilis group. |
| AID410201 | Antibacterial activity against Staphylococcus aureus by broth micro dilution method | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24 | A facile synthesis, antibacterial, and antitubercular studies of some piperidin-4-one and tetrahydropyridine derivatives. |
| AID577132 | Mean residence time in two-compartment pharmacokinetic/pharmacodynamic model at 800 mg, bid administered as 0.5 hr infusion over 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID583203 | Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus isolate MU50 after 24 hrs by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | In vitro activity of the new multivalent glycopeptide-cephalosporin antibiotic TD-1792 against vancomycin-nonsusceptible Staphylococcus isolates. |
| AID532795 | Antibacterial activity against vancomycin-intermediate Staphylococcus aureus IL after 24 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Improved antimicrobial activity of linezolid against vancomycin-intermediate Staphylococcus aureus. |
| AID1519036 | Antibacterial activity against methicillin-resistant Staphylococcus aureus assessed as complete reduction in bacterial cell growth by CLSI protocol based broth liquid microdilution method | 2020 | European journal of medicinal chemistry, Jan-01, Volume: 185 | Optimization of biaryloxazolidinone as promising antibacterial agents against antibiotic-susceptible and antibiotic-resistant gram-positive bacteria. |
| AID542708 | fAUC (24 hrs) in Bacillus anthracis infected in vitro hollow fiber PK/PD model at simulated dose of 600 mg /day administered as 6 divided doses every 4 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID1852682 | Antibacterial activity against efflux pump lacking Escherichia coli assessed as inhibition of bacterial growth | |||
| AID260744 | Antibacterial activity against Escherichia coli J53 | 2006 | Journal of medicinal chemistry, Feb-23, Volume: 49, Issue:4 | Hybrid antibacterials. DNA polymerase-topoisomerase inhibitors. |
| AID245011 | Minimal inhibitory concentration against Staphylococcus epidermidis ATCC 12228 | 2004 | Bioorganic & medicinal chemistry letters, Sep-20, Volume: 14, Issue:18 | Synthesis and antibacterial activity of some aryloxy/thioaryloxy oxazolidinone derivatives. |
| AID285144 | Antimicrobial activity against viridans group Streptococcus anginosus by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID1547714 | Antibacterial activity against Bacillus licheniformis ATCC 12759 by broth microdilution method | 2020 | ACS medicinal chemistry letters, Mar-12, Volume: 11, Issue:3 | Structure-Activity Relationship for the Oxadiazole Class of Antibacterials. |
| AID562158 | Antimicrobial activity against heterogeneous vancomycin-intermediate Staphylococcus aureus 168 measured on day 5 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID291410 | Antibacterial activity against methicillin-resistant Staphylococcus aureus 05-3 after 18 to 24 hrs | 2007 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 17, Issue:16 | Synthesis and antibacterial activity of novel fluoroquinolones containing substituted piperidines. |
| AID577094 | T>MIC in Staphylococcus aureus RN4220 in two-compartment pharmacokinetic/pharmacodynamic model at 600 mg, bid administered as 0.5 hr infusion for 2 days | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID278917 | Antibacterial activity against linezolid-susceptible Enterococcus faecium | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | In vitro antibacterial activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. |
| AID576870 | Bactericidal activity against 14 hrs peripheral compartment culture samples of Enterococcus faecalis Ef1497 MutM3 in two-compartment pharmacokinetic/pharmacodynamic model assessed as effect on bacterial count at 200 mg, bid administered as 0.5 hr infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID571821 | Antibacterial activity against Bifidobacterium longum by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID1126483 | Antimicrobial activity against penicillin- and erythromycin-resistant Streptococcus pneumoniae in presence of 2.5% horse blood | 2014 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 24, Issue:8 | Synthesis, antibiotic activity and structure-activity relationship study of some 3-enaminetetramic acids. |
| AID582985 | Antimicrobial activity against glycopeptide-resistant Enterococcus faecalis isolate HS06188 harboring MLST sequence type ST78 and pulsotype A expressing vanA gene cluster isolated from urine of patient by Etest | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | vanM, a new glycopeptide resistance gene cluster found in Enterococcus faecium. |
| AID1501362 | Antibacterial activity against vancomycin-resistant Staphylococcus aureus isolate 10 after 20 hrs by broth microdilution assay | 2017 | European journal of medicinal chemistry, Oct-20, Volume: 139 | Arylthiazole antibiotics targeting intracellular methicillin-resistant Staphylococcus aureus (MRSA) that interfere with bacterial cell wall synthesis. |
| AID523810 | Antimicrobial activity against linezolid-susceptible coagulase-negative Staphylococcus assessed as inhibition of microbial growth at 0.5 ug/ml by CLSI method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative activities of TR-700 (torezolid) against staphylococcal blood isolates collected in Spain. |
| AID429420 | Antibacterial activity against methicillin-sensitive coagulase-negative Staphylococcus by agar dilution method | 2009 | European journal of medicinal chemistry, Aug, Volume: 44, Issue:8 | Synthesis and antibacterial activity of novel 5-(4-methyl-1H-1,2,3-triazole) methyl oxazolidinones. |
| AID562161 | Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus 555 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID558707 | Antimicrobial activity against heterogeneous vancomycin-intermediate Staphylococcus aureus 168 measured on day 40 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID637968 | Antibacterial activity against Escherichia coli ATCC 25922 after overnight incubation by twofold broth dilution technique | 2012 | Bioorganic & medicinal chemistry, Jan-01, Volume: 20, Issue:1 | Efficient microwave-assisted synthesis, antibacterial activity and high fluorescence of 5 benzimidazolyl-2'-deoxyuridines. |
| AID292609 | Antimicrobial activity against Enterococcus faecalis ATCC 29212 by agar dilution method | 2007 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 17, Issue:17 | Synthesis and antibacterial activity of novel oxazolidinones with methylene oxygen- and methylene sulfur-linked substituents at C5-position. |
| AID1451764 | Antibacterial activity against Staphylococcus aureus Mu50 infected in BALB/c mouse assessed as reduction of bacterial burden in heart at 0.4 mg, ip bid for 4.5 days administered 6 hrs post bacterial infection measured 108 hrs post infection relative to co | 2017 | Journal of medicinal chemistry, 10-12, Volume: 60, Issue:19 | Novel Inhibitors of Staphyloxanthin Virulence Factor in Comparison with Linezolid and Vancomycin versus Methicillin-Resistant, Linezolid-Resistant, and Vancomycin-Intermediate Staphylococcus aureus Infections in Vivo. |
| AID285354 | Decrease in Panton-Valentine leukocidin level in community acquired methicillin-resistant Staphylococcus aureus HT20020488 in CYY medium | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Effect of antibiotics on Staphylococcus aureus producing Panton-Valentine leukocidin. |
| AID558490 | Antimicrobial activity against heterogeneous vancomycin-intermediate Staphylococcus aureus 873 measured on day 15 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID524717 | Antibacterial activity against linezolid-resistant Staphylococcus aureus ATCC 29213 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro antibacterial activity of CE-156811, a novel analog derived from hygromycin A. |
| AID528845 | Antimicrobial activity against methicillin-resistant Staphylococcus epidermidis isolated from ICU patient wound assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID1117372 | Antimicrobial activity against Staphylococcus aureus SG511 assessed as inhibition zone at 37 degC for 24 hrs by agar diffusion method | 2010 | MedChemComm, Aug-01, Volume: 1, Issue:2 | Syntheses and biological evaluation of new cephalosporin-oxazolidinone conjugates. |
| AID533400 | Antimicrobial activity against Clostridium paraputrificum assessed as resistant isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activities of doripenem, a new broad-spectrum carbapenem, against recently collected clinical anaerobic isolates, with emphasis on the Bacteroides fragilis group. |
| AID283397 | Antimicrobial activity against Nocardia transvalensis after 72 hrs by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | In vitro activities of tigecycline and eight other antimicrobials against different Nocardia species identified by molecular methods. |
| AID1174902 | Antibacterial activity against Staphylococcus aureus ATCC 29213 by broth microdilution method | 2014 | Bioorganic & medicinal chemistry, Dec-15, Volume: 22, Issue:24 | New potent antibacterials against Gram-positive multiresistant pathogens: effects of side chain modification and chirality in linezolid-like 1,2,4-oxadiazoles. |
| AID1660513 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after 16 hrs by CLSI-based broth microdilution method | 2020 | Journal of natural products, 06-26, Volume: 83, Issue:6 | Synthesis of the Cyanobacterial Antibiotics Anaephenes A and B. |
| AID205740 | In vitro antibacterial activity against Staphylococcus epidermidis | 2003 | Bioorganic & medicinal chemistry letters, Jul-21, Volume: 13, Issue:14 | Synthesis and antibacterial activity of oxazolidinone containing sulphonyl group. |
| AID374009 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus 543 after 17 passages with daptomycin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID565753 | Antimicrobial activity against oxacillin-resistant Staphylococcus haemolyticus clinical isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID477371 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 70069 after 24 hrs | 2009 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13 | Synthesis and antibacterial evaluation of isoxazolinyl oxazolidinones: Search for potent antibacterial. |
| AID1308239 | Bacteriostatic activity against methicillin-susceptible Staphylococcus aureus ATCC 29213 | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10 | Structure-Activity Relationship for the 4(3H)-Quinazolinone Antibacterials. |
| AID285143 | Antimicrobial activity against beta hemolytic Streptococcus group G by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID1151621 | Toxicity in female rat assessed as effect on WBC count at 100 mg/kg/day, po bid administered for 4 weeks (Rvb = 3.66 x 10'9/L) | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID370008 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus Smith infected in C3H mouse assessed as eradication at 12.5 mg/kg/day, po administered within 15 mins of infection assessed per gram of kidney measured after 48 hrs by organ burd | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vivo efficacy of a novel oxazolidinone compound in two mouse models of infection. |
| AID541814 | Antimicrobial activity against Enterococcus hirae clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID1778667 | Ratio of MBC to MIC against penicillin-susceptible Bacillus subtilis ATCC 9372 | 2021 | European journal of medicinal chemistry, Oct-05, Volume: 221 | Design, synthesis and evaluation of novel 9-arylalkyl-10-methylacridinium derivatives as highly potent FtsZ-targeting antibacterial agents. |
| AID285075 | Antimicrobial activity against viridans group Streptococcus anginosus at 1 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID542700 | fCmax in Bacillus anthracis infected in vitro hollow fiber PK/PD model at simulated dose of 600 mg /day administered as 2 divided doses every 12 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID207720 | In vitro minimum inhibitory concentration (MIC) against Staphylococcus aureus UC12673 | 2003 | Journal of medicinal chemistry, Jan-16, Volume: 46, Issue:2 | Identification of phenylisoxazolines as novel and viable antibacterial agents active against Gram-positive pathogens. |
| AID285517 | Antibacterial activity against Enterococcus faecium | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | In vitro and in vivo antibacterial activities of heteroaryl isothiazolones against resistant gram-positive pathogens. |
| AID285543 | Cmax in mouse at 20 mg/kg, sc | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | In vitro and in vivo antibacterial activities of heteroaryl isothiazolones against resistant gram-positive pathogens. |
| AID535776 | Antimicrobial activity against Mycobacterium ulcerans ATCC 19423 harboring pTY60K containing pMH94 carrying the luxAB gene under the hsp60 promoter after 7 days determined according to RLU count by real-time luminescence method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Rapid assessment of antibacterial activity against Mycobacterium ulcerans by using recombinant luminescent strains. |
| AID285160 | Antimicrobial activity against non replicating persistence Mycobacterium tuberculosis H37Rv in aerobic condition assessed as bacterial density after 7 days | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Low-oxygen-recovery assay for high-throughput screening of compounds against nonreplicating Mycobacterium tuberculosis. |
| AID267720 | Antimicrobial activity against Staphylococcus aureus | 2006 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 16, Issue:13 | Synthesis and structure-activity studies of antibacterial oxazolidinones containing dihydrothiopyran or dihydrothiazine C-rings. |
| AID559794 | Antimicrobial activity against heterogeneous vancomycin-intermediate Staphylococcus aureus assessed as growth inhibition at 2 times MIC | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID68070 | Antibacterial activity against vancomycin - resistant Enterococcus faecium (OC 3312 VRE) | 2001 | Bioorganic & medicinal chemistry letters, Jul-23, Volume: 11, Issue:14 | Novel piperidinyloxy oxazolidinone antimicrobial agents. |
| AID1197114 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus ATCC 29213 after 16 to 20 hrs by broth microdilution method | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3 | Structure-activity relationship for the oxadiazole class of antibiotics. |
| AID1852663 | Antibacterial activity against multidrug resistant Klebsiella pneumoniae ATCC43816 assessed as inhibition of bacterial growth incubated for 24 hrs in MHI medium by twofold serial dilution method | |||
| AID1407934 | Antibacterial activity against Streptococcus pyogenes ARC838 after 24 hrs by broth microdilution method | 2018 | European journal of medicinal chemistry, Sep-05, Volume: 157 | Discovery of dual GyrB/ParE inhibitors active against Gram-negative bacteria. |
| AID1393959 | Antibacterial activity against methicillin resistant Staphylococcus epidermidis NR 46386 after 16 to 20 hrs by CLSI method | 2018 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 28, Issue:16 | 3-Hydroxy-1,5-dihydro-2H-pyrrol-2-ones as novel antibacterial scaffolds against methicillin-resistant Staphylococcus aureus. |
| AID1703732 | Antibacterial activity against methicillin-resistant Streptococcus pneumoniae ATCC 700677 assessed as inhibition of bacterial growth measured after 18 to 20 hrs by CLSI protocol based broth microdilution method | 2020 | European journal of medicinal chemistry, Sep-15, Volume: 202 | Evaluation of N-phenyl-2-aminothiazoles for treatment of multi-drug resistant and intracellular Staphylococcus aureus infections. |
| AID410106 | Antimicrobial activity against Linezolid-resistant Enterococcus faecalis P5 by NCCLS method | 2008 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 18, Issue:23 | Design at the atomic level: design of biaryloxazolidinones as potent orally active antibiotics. |
| AID576882 | Ratio of Cmax to MIC for 0.5 hrs peripheral compartment culture samples of Staphylococcus aureus RN4220 in two-compartment pharmacokinetic/pharmacodynamic model at 600 mg, bid administered as 0.5 hr infusion for 2 days | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID1852677 | Antibacterial activity against efflux pump lacking/recombinant OM pore producing Acinetobacter baumannii assessed as inhibition of bacterial growth | |||
| AID542704 | fAUC (24 hrs) in Bacillus anthracis infected in vitro hollow fiber PK/PD model at simulated dose of 500 mg /day administered as 2 divided doses every 12 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID542880 | fCmax in Bacillus anthracis infected in vitro hollow fiber PK/PD model at simulated dose of 800 mg administered once every 24 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID1252237 | Antimicrobial activity against Staphylococcus aureus ATCC 29213 | 2015 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 25, Issue:21 | Rapid synthesis and antimicrobial activity of novel 4-oxazolidinone heterocycles. |
| AID319161 | Elimination half life in human | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7 | Linezolid (ZYVOX), the first member of a completely new class of antibacterial agents for treatment of serious gram-positive infections. |
| AID1174913 | Antibacterial activity against linezolid-sensitive methicillin-sensitive Staphylococcus aureus by broth microdilution method | 2014 | Bioorganic & medicinal chemistry, Dec-15, Volume: 22, Issue:24 | New potent antibacterials against Gram-positive multiresistant pathogens: effects of side chain modification and chirality in linezolid-like 1,2,4-oxadiazoles. |
| AID1591538 | Antibacterial activity against Bacillus subtilis ATCC 9372 incubated for 24 hrs by CLSI protocol based broth microdilution method | 2019 | Bioorganic & medicinal chemistry, 07-15, Volume: 27, Issue:14 | Discovery of 1,3,4-oxadiazol-2-one-containing benzamide derivatives targeting FtsZ as highly potent agents of killing a variety of MDR bacteria strains. |
| AID1415065 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus isolate 1 after 16 hrs by agar dilution method | 2018 | Journal of medicinal chemistry, 12-27, Volume: 61, Issue:24 | Semisynthesis of Platensimycin Derivatives with Antibiotic Activities in Mice via Suzuki-Miyaura Cross-Coupling Reactions. |
| AID544636 | Antimicrobial activity against Staphylococcus aureus Xen 30 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Effect of electrical current on the activities of antimicrobial agents against Pseudomonas aeruginosa, Staphylococcus aureus, and Staphylococcus epidermidis biofilms. |
| AID558503 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus 525 measured on day 20 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID387455 | Antibacterial activity against beta-lactamase deficient Moraxella catarrhalis DRCC 300 | 2008 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 18, Issue:18 | Novel and potent oxazolidinone antibacterials featuring 3-indolylglyoxamide substituents. |
| AID583389 | Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus isolate MU50 assessed as bacterial count at 16 times MIC after 24 hrs by colony counting method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | In vitro activity of the new multivalent glycopeptide-cephalosporin antibiotic TD-1792 against vancomycin-nonsusceptible Staphylococcus isolates. |
| AID576880 | Bactericidal activity against 24 hrs peripheral compartment culture samples of Enterococcus faecalis Ef1497 MutM3 in two-compartment pharmacokinetic/pharmacodynamic model assessed as effect on bacterial count at 600 mg, bid administered as 0.5 hr infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID67399 | In vitro antibacterial activity against Enterococcus faecalis EFS008 (E.f.2) | 2003 | Bioorganic & medicinal chemistry letters, Nov-17, Volume: 13, Issue:22 | Synthesis and in vitro activity of novel isoxazolyl tetrahydropyridinyl oxazolidinone antibacterial agents. |
| AID581027 | Inhibition of cell wall synthesis in Staphylococcus epidermidis ATCC 23760 assessed as incorporation of [3H]N-acetylglucosamine at 2 ug/ml after 60 mins by liquid scintillation counter | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Mode of action of Ranbezolid against staphylococci and structural modeling studies of its interaction with ribosomes. |
| AID1677802 | Antibacterial activity against Pseudomonas aeruginosa ATCC27853 incubated for 24 hrs by CLSI-based broth microdilution method | 2020 | Bioorganic & medicinal chemistry, 11-01, Volume: 28, Issue:21 | Design, synthesis of novel 4,5-dihydroisoxazole-containing benzamide derivatives as highly potent FtsZ inhibitors capable of killing a variety of MDR Staphylococcus aureus. |
| AID373314 | Antibacterial activity against vancomycin-sensitive Enterococcus clinical isolate after 18 hrs by NCCLS M7-A4 method | 2009 | European journal of medicinal chemistry, Mar, Volume: 44, Issue:3 | Synthesis, antibacterial and anticonvulsant evaluations of some cyclic enaminones. |
| AID531562 | Antibacterial activity against coagulase-negative Staphylococcus warneri obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID542897 | fAUC ( 24 hrs) in Bacillus anthracis infected in vitro hollow fiber PK/PD model at simulated dose of 700 mg administered every 24 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID1680038 | Antibacterial activity against NDM1 producing carbapenem-resistant Enterobacteriaceae clinical isolate 8 assessed as reduction in bacterial growth incubated for 16 to 20 hrs by CLSI-based broth microdilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Synthesis and antibacterial bioactivities of cationic deacetyl linezolid amphiphiles. |
| AID562615 | Antimicrobial activity against methicillin-sensitive Staphylococcus aureus assessed as susceptible isolates by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | In vitro activities of three new dihydrofolate reductase inhibitors against clinical isolates of gram-positive bacteria. |
| AID1474195 | Antibacterial activity against Escherichia coli 1411 harboring delta-acrAB after 18 to 22 hrs in absence of colistin by broth microdilution method | 2017 | Journal of medicinal chemistry, 03-23, Volume: 60, Issue:6 | Phenylthiazole Antibacterial Agents Targeting Cell Wall Synthesis Exhibit Potent Activity in Vitro and in Vivo against Vancomycin-Resistant Enterococci. |
| AID1547720 | Antibacterial activity against Enterococcus faecium NCTC 7171 by broth microdilution method | 2020 | ACS medicinal chemistry letters, Mar-12, Volume: 11, Issue:3 | Structure-Activity Relationship for the Oxadiazole Class of Antibacterials. |
| AID1596542 | Antibacterial activity against Staphylococcus aureus NRS107 assessed as reduction in bacterial cell growth incubated for 18 to 20 hrs by broth microdilution method | 2019 | European journal of medicinal chemistry, Aug-01, Volume: 175 | Lipophilic efficient phenylthiazoles with potent undecaprenyl pyrophosphatase inhibitory activity. |
| AID1154472 | Antibacterial activity against clinical isolate of methicillin-sensitive Staphylococcus aureus infected in iv dosed mouse administered 1 hr after infection for 4 days | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | Design, synthesis, and structure-activity relationship studies of novel thioether pleuromutilin derivatives as potent antibacterial agents. |
| AID1680064 | Antibacterial activity against methicillin-resistant Staphylococcus aureus clinical isolate 2 assessed as reduction in bacterial growth incubated for 16 to 20 hrs by CLSI-based broth microdilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Synthesis and antibacterial bioactivities of cationic deacetyl linezolid amphiphiles. |
| AID519998 | Antimicrobial activity against Streptococcus pyogenes | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID687499 | Drug excretion in rat urine | 2012 | Bioorganic & medicinal chemistry, Oct-15, Volume: 20, Issue:20 | Antitubercular nitrofuran isoxazolines with improved pharmacokinetic properties. |
| AID542904 | Antimicrobial activity against Bacillus anthracis infected in in vitro hollow fiber PK/PD model assessed as bacterial regrowth at 300 mg administered once every 24 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID560799 | Absorption half life in human adults with pulmonary tuberculosis at 600 mg administered daily for 7 days | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Population pharmacokinetics of linezolid in adults with pulmonary tuberculosis. |
| AID429423 | Antibacterial activity against vancomycin-sensitive Enterococcus by agar dilution method | 2009 | European journal of medicinal chemistry, Aug, Volume: 44, Issue:8 | Synthesis and antibacterial activity of novel 5-(4-methyl-1H-1,2,3-triazole) methyl oxazolidinones. |
| AID528844 | Antimicrobial activity against penicillin-resistant Streptococcus pneumoniae assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID534788 | Antimicrobial activity against community-acquired methicillin-resistant Staphylococcus aureus assessed as susceptible isolates by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | In vitro activity of ceftaroline against community-associated methicillin-resistant, vancomycin-intermediate, vancomycin-resistant, and daptomycin-nonsusceptible Staphylococcus aureus isolates. |
| AID532796 | Antibacterial activity against vancomycin-intermediate Staphylococcus aureus PC after 24 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Improved antimicrobial activity of linezolid against vancomycin-intermediate Staphylococcus aureus. |
| AID533631 | Antimicrobial activity against Propionibacterium acnes by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activities of doripenem, a new broad-spectrum carbapenem, against recently collected clinical anaerobic isolates, with emphasis on the Bacteroides fragilis group. |
| AID24540 | terminal disposition half-life was evaluated in male Dawley rats at a dose of 25 mg/kg when taken perorally | 1998 | Journal of medicinal chemistry, Dec-17, Volume: 41, Issue:26 | Nitrogen-carbon-linked (azolylphenyl)oxazolidinones with potent antibacterial activity against the fastidious gram-negative organisms Haemophilus influenzae and Moraxella catarrhalis. |
| AID523793 | Antimicrobial activity against oxacillin-susceptible coagulase-negative Staphylococcus aureus by CLSI method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative activities of TR-700 (torezolid) against staphylococcal blood isolates collected in Spain. |
| AID1574836 | Antibacterial activity against clinical isolates of methicillin-resistant Staphylococcus aureus by broth liquid microdilution method | 2019 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 29, Issue:3 | Design and synthesis of biaryloxazolidinone derivatives containing a rhodanine or thiohydantoin moiety as novel antibacterial agents against Gram-positive bacteria. |
| AID525130 | Antibacterial activity against Staphylococcus aureus KM187 after 18 to 24 hrs by broth microdilution method selected after 16 ug/ml drug exposure for 6 hrs by culture absorbance method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Delayed development of linezolid resistance in Staphylococcus aureus following exposure to low levels of antimicrobial agents. |
| AID541088 | Antibacterial activity against 1 x10'6 to 5 x10'6 CFU/ml methicillin-resistant Staphylococcus aureus ATCC 43300 assessed as log decrease in bacterial count at 4 times MIC after 24 hrs by time kill study | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Linezolid alone or combined with rifampin against methicillin-resistant Staphylococcus aureus in experimental foreign-body infection. |
| AID390331 | Antimicrobial activity against quinolone-resistant Streptococcus pneumoniae 376 | 2008 | Journal of natural products, Dec, Volume: 71, Issue:12 | Citreamicins with potent gram-positive activity. |
| AID206469 | The compound was evaluated for its anti-bacterial activity against methicillin resistant Staphylococcus aureus | 1998 | Journal of medicinal chemistry, Dec-17, Volume: 41, Issue:26 | Nitrogen-carbon-linked (azolylphenyl)oxazolidinones with potent antibacterial activity against the fastidious gram-negative organisms Haemophilus influenzae and Moraxella catarrhalis. |
| AID573157 | Antibacterial activity against vancomycin-resistant Enterococcus faecium assessed as resistant isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID575078 | Antimicrobial activity against Streptococcus pneumoniae serotype 35B assessed as percent susceptible isolates by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID1327115 | Antibacterial activity against Bacillus subtilis NCIM 2010 at 10 ug/ml measured after 12 hrs by spectrophotometric method | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Design, synthesis and biological evaluation of novel azaspiro analogs of linezolid as antibacterial and antitubercular agents. |
| AID520224 | Antimicrobial activity against Enterococcus faecium A9621 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID541069 | Tmax in cage fluid of Albino guiena pig at 75 mg/kg, ip | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Linezolid alone or combined with rifampin against methicillin-resistant Staphylococcus aureus in experimental foreign-body infection. |
| AID209622 | In vitro minimum inhibitory concentration against Streptococcus pyogenes penicillin sensitive | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | New classes of antibacterial oxazolidinones with C-5, methylene O-linked heterocyclic side chains. |
| AID558483 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus 525 measured on day 10 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID1308262 | Antibacterial activity against methicillin-resistant Staphylococcus aureus NRS70 in ICR mouse neutropenic thigh infection model assessed as reduction in bacterial load at 10 mg/kg, sc tid administered every 8 hrs starting from 1 hr post infection and meas | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10 | Structure-Activity Relationship for the 4(3H)-Quinazolinone Antibacterials. |
| AID562588 | Antimicrobial activity against Enterococcus faecium expressing VanA gene clinical isolates assessed as resistant isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID1873907 | Antibacterial activity against Escherichia coli ATCC 25922 incubated for 16 to 20 hrs by broth microdilution method | 2022 | European journal of medicinal chemistry, Aug-05, Volume: 238 | Design, synthesis and activity against drug-resistant bacteria evaluation of C-20, C-23 modified 5-O-mycaminosyltylonolide derivatives. |
| AID523804 | Antimicrobial activity against oxacillin-susceptible Staphylococcus aureus assessed as inhibition of microbial growth at =< 0.25 ug/ml by CLSI method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative activities of TR-700 (torezolid) against staphylococcal blood isolates collected in Spain. |
| AID1671917 | Antibacterial activity against Enterococcus faecium ATCC 35667 assessed as minimum inhibitory concentration required for >=90% inhibition of bacterial growth by CLSI protocol based broth microdilution assay | 2019 | European journal of medicinal chemistry, Apr-01, Volume: 167 | An optimised series of substituted N-phenylpyrrolamides as DNA gyrase B inhibitors. |
| AID576409 | AUC in two-compartment pharmacokinetic/pharmacodynamic model at 600 mg, bid administered as 0.5 hrs infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID563495 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis EF NJ1 infected in New Zealand White rabbit assessed as log reduction of bacterial count in aortic valve vegetations at 10 mg/kg, administered through ear vein every 12 hrs for 4 da | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | In vivo activity of a novel anti-methicillin-resistant Staphylococcus aureus cephalosporin, ceftaroline, against vancomycin-susceptible and -resistant Enterococcus faecalis strains in a rabbit endocarditis model: a comparative study with linezolid and van |
| AID1311363 | Antibacterial activity against Pseudomonas aeruginosa PA14 measured after 18 hrs by broth microdilution assay | 2016 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15 | An evolved oxazolidinone with selective potency against Mycobacterium tuberculosis and gram positive bacteria. |
| AID729177 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus ATCC 19636 infected in iv dosed systemic infection mouse model administered 1 hr post infection measured after 48 hrs | 2013 | Journal of medicinal chemistry, Mar-28, Volume: 56, Issue:6 | Solubility-driven optimization of (pyridin-3-yl) benzoxazinyl-oxazolidinones leading to a promising antibacterial agent. |
| AID564323 | Antimicrobial activity against log-phase methicillin-resistant Staphylococcus aureus HUSA 304 assessed as resistant bacteria on coverslip selected on 4 ug/ml of compound measured on day 11 post treatment | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | Efficacy of high doses of daptomycin versus alternative therapies against experimental foreign-body infection by methicillin-resistant Staphylococcus aureus. |
| AID1269335 | Efflux ratio of apparent permeability from basolateral to apical side over apical to basolateral side in human Caco2 cells | 2016 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 26, Issue:2 | Synthesis and evaluation of pretomanid (PA-824) oxazolidinone hybrids. |
| AID284964 | Antimicrobial activity against Corynebacterium amycolatum at 0.12 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID558499 | Antimicrobial activity against heterogeneous vancomycin-intermediate Staphylococcus aureus 168 measured on day 20 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID1233139 | Antibacterial activity against patient-derived methicillin-resistant Staphylococcus aureus K1 after 18 to 20 hrs by microbroth dilution method | 2015 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 25, Issue:13 | Thiol activated prodrugs of sulfur dioxide (SO2) as MRSA inhibitors. |
| AID370025 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus Smith infected in C3H mouse assessed as reduction in log number of CFU at 6.25 mg/kg/day, iv administered within 15 mins of infection measured after 48 hrs by organ burden assay | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vivo efficacy of a novel oxazolidinone compound in two mouse models of infection. |
| AID1519035 | Antibacterial activity against Staphylococcus aureus ATCC 29213 assessed as complete reduction in bacterial cell growth by CLSI protocol based broth liquid microdilution method | 2020 | European journal of medicinal chemistry, Jan-01, Volume: 185 | Optimization of biaryloxazolidinone as promising antibacterial agents against antibiotic-susceptible and antibiotic-resistant gram-positive bacteria. |
| AID531564 | Antibacterial activity against methicillin-susceptible, coagulase-negative Staphylococcus obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID1852681 | Antibacterial activity against recombinant OM pore producing Escherichia coli assessed as inhibition of bacterial growth | |||
| AID390332 | Antimicrobial activity against ampicillin-resistant Haemophilus influenzae 1742 | 2008 | Journal of natural products, Dec, Volume: 71, Issue:12 | Citreamicins with potent gram-positive activity. |
| AID1680010 | Antibiofilm activity against Escherichia coli ATCC 25922 assessed as inhibition of biofilm formation incubated for 24 hrs by crystal violet staining assay | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Synthesis and antibacterial bioactivities of cationic deacetyl linezolid amphiphiles. |
| AID285345 | Antibacterial activity against community acquired methicillin-resistant Staphylococcus aureus HT20041010 in Mueller-Hinton medium | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Effect of antibiotics on Staphylococcus aureus producing Panton-Valentine leukocidin. |
| AID1117396 | Antimicrobial activity against Mycobacterium vaccae IMET assessed as inhibition zone at 37 degC for 24 hrs by agar diffusion method | 2010 | MedChemComm, Aug-01, Volume: 1, Issue:2 | Syntheses and biological evaluation of new cephalosporin-oxazolidinone conjugates. |
| AID1395979 | Bactericidal activity against methicillin-resistant Staphylococcus aureus BAA-1707 planktonic cells after 24 hrs by calgary biofilm device method | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9 | An Efficient Buchwald-Hartwig/Reductive Cyclization for the Scaffold Diversification of Halogenated Phenazines: Potent Antibacterial Targeting, Biofilm Eradication, and Prodrug Exploration. |
| AID291411 | Antibacterial activity against Streptococcus pneumoniae 05-9 after 18 to 24 hrs | 2007 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 17, Issue:16 | Synthesis and antibacterial activity of novel fluoroquinolones containing substituted piperidines. |
| AID1151776 | Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate 0605 in mouse thigh infection model assessed as reduction of log10 CFU per thigh at 5 mg/kg, po | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID552855 | Antibacterial activity against Staphylococcus aureus infected in po dosed in vivo acute model administered bid for 1 day | 2011 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1 | The discovery and structure-activity relationships leading to CE-156811, a difluorophenyl cyclopropyl fluoroether: a novel potent antibacterial analog derived from hygromycin A. |
| AID285130 | Antimicrobial activity against viridans group Streptococcus sanguinis at <= 0.06 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID535023 | Antimicrobial activity against vancomycin intermediate Staphylococcus aureus NRS-22 expressing SCCmec type 2 element by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | In vitro activity of ceftaroline against community-associated methicillin-resistant, vancomycin-intermediate, vancomycin-resistant, and daptomycin-nonsusceptible Staphylococcus aureus isolates. |
| AID562625 | Antimicrobial activity against Group A Streptococcus assessed as susceptible isolates by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | In vitro activities of three new dihydrofolate reductase inhibitors against clinical isolates of gram-positive bacteria. |
| AID1194834 | Antibacterial activity against methicillin-sensitive Staphylococcus epidermidis incubated for 16 hrs by agar dilution method | 2015 | Bioorganic & medicinal chemistry letters, , Volume: 25, Issue:10 | Synthesis and structure-activity relationship studies of novel [6,6,5] tricyclic oxazolidinone derivatives as potential antibacterial agents. |
| AID1180582 | Ratio of MIC for 2 times drug resistance selected Staphylococcus aureus ARC516-2F to MIC for Staphylococcus aureus ARC516 | 2014 | Journal of medicinal chemistry, Jul-24, Volume: 57, Issue:14 | Optimization of pyrrolamide topoisomerase II inhibitors toward identification of an antibacterial clinical candidate (AZD5099). |
| AID730384 | Antibacterial activity against macrolides, lincosamides, streptogramin B and methicillin-resistant Staphylococcus aureus 1015-00 assessed as growth inhibition | 2013 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 23, Issue:6 | Novel 3-O-carbamoyl erythromycin A derivatives (carbamolides) with activity against resistant staphylococcal and streptococcal isolates. |
| AID1680012 | Antibiofilm activity against 24 hrs preformed biofilm of Escherichia coli ATCC 25922 assessed as eradication of preformed biofilm incubated for 24 hrs by crystal violet staining assay | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Synthesis and antibacterial bioactivities of cationic deacetyl linezolid amphiphiles. |
| AID519992 | Antimicrobial activity against vancomycin-susceptible Enterococcus faecium nosocomial isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID590062 | Antibacterial activity against Haemophilus influenzae by agar dilution method | 2011 | European journal of medicinal chemistry, Apr, Volume: 46, Issue:4 | Discovery of torezolid as a novel 5-hydroxymethyl-oxazolidinone antibacterial agent. |
| AID1400053 | Antibacterial activity against Klebsiella pneumoniae ATCC 12019 incubated for 24 hrs under aerobic condition by MABA | 2018 | Bioorganic & medicinal chemistry, 09-15, Volume: 26, Issue:17 | An antimycobacterial pleuromutilin analogue effective against dormant bacilli. |
| AID326283 | Antibacterial activity against methicillin-resistant Staphylococcus aureus 5098 at 4 hrs daily exposure for 1 day by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Comparative activities of daptomycin, linezolid, and tigecycline against catheter-related methicillin-resistant Staphylococcus bacteremic isolates embedded in biofilm. |
| AID1190638 | Inhibition of biofilm formation of Pseudomonas aeruginosa PAO1 incubated for 18 hrs by crystal violet staining based spectroscopy | 2015 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 25, Issue:4 | Biofilm inhibition of linezolid-like Schiff bases: synthesis, biological activity, molecular docking and in silico ADME prediction. |
| AID323786 | Antibacterial activity against methicillin-resistant Staphylococcus aureus Xen1 infected neutropenic CD1 mouse assessed as mouse survival at 50 mg/kg, sc after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Rapid bactericidal activity of daptomycin against methicillin-resistant and methicillin-susceptible Staphylococcus aureus peritonitis in mice as measured with bioluminescent bacteria. |
| AID561745 | Antibacterial activity against Methicillin-sensitive Staphylococcus aureus assessed as susceptible isolates by CLSI broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Potency and bactericidal activity of iclaprim against recent clinical gram-positive isolates. |
| AID564815 | Antimicrobial activity against methicillin-resistant coagulase-negative Staphylococcus epidermidis assessed as susceptible isolates after 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID1193400 | Inhibition of recombinant Bacillus anthracis PurE assessed as inhibition of 4-carboxy-amino-imidazole ribonucleotide to N5-carboxy-amino-imidazole ribonucleotide conversion preincubated for 1.5 mins at 10 uM by mass spectrometry analysis | 2015 | Bioorganic & medicinal chemistry, Apr-01, Volume: 23, Issue:7 | Identification of Bacillus anthracis PurE inhibitors with antimicrobial activity. |
| AID591661 | Antimicrobial activity against multidrug-resistant Enterococcus faecalis after 18 hrs by agar dilution method | 2011 | Journal of medicinal chemistry, Apr-14, Volume: 54, Issue:7 | A new DNA gyrase inhibitor subclass of the cyclothialidine family based on a bicyclic dilactam-lactone scaffold. Synthesis and antibacterial properties. |
| AID763981 | Antibacterial activity against Escherichia coli ATCC 25922 after 18 hrs by NCCLS agar dilution method | 2013 | European journal of medicinal chemistry, Aug, Volume: 66 | Synthesis and antibacterial activities of N-substituted-glycinyl 1H-1,2,3-triazolyl oxazolidinones. |
| AID520000 | Antimicrobial activity against Moraxella catarrhalis | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID292613 | Antimicrobial activity against Moraxella catarrhalis M2 by agar dilution method | 2007 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 17, Issue:17 | Synthesis and antibacterial activity of novel oxazolidinones with methylene oxygen- and methylene sulfur-linked substituents at C5-position. |
| AID575083 | Antimicrobial activity against multiple drug resistant Streptococcus pneumoniae serotype 19F assessed as percent susceptible isolates by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID576400 | Residual concentration at the end of the administration interval in two-compartment pharmacokinetic/pharmacodynamic model at 600 mg, bid administered as 0.5 hrs infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID326282 | Antibacterial activity against methicillin-resistant Staphylococcus aureus 4930 at 4 hrs daily exposure for 1 day by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Comparative activities of daptomycin, linezolid, and tigecycline against catheter-related methicillin-resistant Staphylococcus bacteremic isolates embedded in biofilm. |
| AID410118 | Antimicrobial activity against mef (A) Streptococcus pneumoniae 02J1175 in orally dosed mouse peritonitis model | 2008 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 18, Issue:23 | Design at the atomic level: design of biaryloxazolidinones as potent orally active antibiotics. |
| AID548534 | Antimicrobial activity against viridans group Streptococcus by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Activities of dalbavancin against a worldwide collection of 81,673 gram-positive bacterial isolates. |
| AID1446753 | Bactericidal activity against methicillin-resistant Staphylococcus aureus USA400 NRS123 clinical isolate after 18 hrs by broth microdilution method | 2017 | European journal of medicinal chemistry, Apr-21, Volume: 130 | Diphenylurea derivatives for combating methicillin- and vancomycin-resistant Staphylococcus aureus. |
| AID759692 | Antibacterial activity against methicillin-resistant Staphylococcus aureus 433 assessed as growth inhibition after 18 to 24 hrs by broth microdilution method | 2013 | European journal of medicinal chemistry, Jul, Volume: 65 | New linezolid-like 1,2,4-oxadiazoles active against Gram-positive multiresistant pathogens. |
| AID520230 | Antimicrobial activity against vancomycin-resistant Enterococcus faecalis 03B1069 | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID1421223 | Antibacterial activity against linezolid-resistant Enterococcus faecalis by broth liquid microdilution method | 2018 | European journal of medicinal chemistry, Oct-05, Volume: 158 | Synthesis and antibacterial activity evaluation of novel biaryloxazolidinone analogues containing a hydrazone moiety as promising antibacterial agents. |
| AID1596566 | Bactericidal activity against vancomycin resistant Staphylococcus aureus VRS12 assessed as reduction in bacterial cell growth incubated for 18 to 20 hrs followed by re-plating on tryptic soy agar plates at 37 degC for 18 hrs by broth microdilution assay | 2019 | European journal of medicinal chemistry, Aug-01, Volume: 175 | Lipophilic efficient phenylthiazoles with potent undecaprenyl pyrophosphatase inhibitory activity. |
| AID369673 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus Smith infected in C3H mouse assessed as mortality at 25 mg/kg/day, po administered within 15 mins of infection measured after 48 hrs by organ burden assay relative to control | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vivo efficacy of a novel oxazolidinone compound in two mouse models of infection. |
| AID528971 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus isolated from ICU patient urine assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID1265130 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 25923 | 2015 | European journal of medicinal chemistry, Dec-01, Volume: 106 | Synthesis and biological evaluation of novel 5-(hydroxamic acid)methyl oxazolidinone derivatives. |
| AID410203 | Antibacterial activity against Staphylococcus epidermidis by broth micro dilution method | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24 | A facile synthesis, antibacterial, and antitubercular studies of some piperidin-4-one and tetrahydropyridine derivatives. |
| AID1079947 | Comments (NB not yet translated). [column 'COMMENTAIRES' in source] | |||
| AID66125 | Antibacterial activity against Enterococcus species | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | Iclaprim, a novel diaminopyrimidine with potent activity on trimethoprim sensitive and resistant bacteria. |
| AID1079931 | Moderate liver toxicity, defined via clinical-chemistry results: ALT or AST serum activity 6 times the normal upper limit (N) or alkaline phosphatase serum activity of 1.7 N. Value is number of references indexed. [column 'BIOL' in source] | |||
| AID1594364 | Antibacterial activity against methicillin-resistant Staphylococcus epidermidis NRS101 after 18 to 24 hrs by broth microdilution assay | 2019 | Bioorganic & medicinal chemistry, 05-01, Volume: 27, Issue:9 | Second-generation aryl isonitrile compounds targeting multidrug-resistant Staphylococcus aureus. |
| AID559557 | Antimicrobial activity against compound-intermediate susceptible Coxiella burnetii isolate CP6 obtained from patient with acute Q fever infected in african green monkey Vero cells after 24 hrs by shell vial assay | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Bacteriostatic and bactericidal activities of tigecycline against Coxiella burnetii and comparison with those of six other antibiotics. |
| AID576394 | Cmax in two-compartment pharmacokinetic/pharmacodynamic model at 600 mg, bid administered as 0.5 hrs infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID528975 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus isolated from ICU patient wound assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID1400038 | Antibacterial activity against Staphylococcus aureus ATCC 25923 incubated for 24 hrs under aerobic condition by MABA | 2018 | Bioorganic & medicinal chemistry, 09-15, Volume: 26, Issue:17 | An antimycobacterial pleuromutilin analogue effective against dormant bacilli. |
| AID1493805 | Antibacterial activity against Staphylococcus aureus VRS10 clinical isolate after 20 hrs by broth microdilution method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Biphenylthiazole antibiotics with an oxadiazole linker: An approach to improve physicochemical properties and oral bioavailability. |
| AID520012 | Antimicrobial activity against Staphylococcus aureus A7817 | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID511433 | Antimicrobial activity against Clostridium perfringens LFM1 assessed as resistance breakpoint by DANMAP method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Resistance to linezolid in a porcine Clostridium perfringens strain carrying a mutation in the rplD gene encoding the ribosomal protein L4. |
| AID576892 | Ratio of Cmax to MIC for 0.5 hrs peripheral compartment culture samples of Enterococcus faecalis Ef1497 in two-compartment pharmacokinetic/pharmacodynamic model at 800 mg, bid administered as 0.5 hr infusion for 2 days | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID499112 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus Smith OC 4172 infected immunocompromized SKH1 mouse assessed as lesion volume at 25 mg/kg/day, sc measured after 48 hrs postinfection (Rvb = 1181 mm3) | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vivo activity of ceftobiprole in murine skin infections due to Staphylococcus aureus and Pseudomonas aeruginosa. |
| AID549014 | Antimicrobial activity against Beta-hemolytic Streptococcus assessed as percent resistant isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Activities of dalbavancin against a worldwide collection of 81,673 gram-positive bacterial isolates. |
| AID576875 | Bactericidal activity against 2 hrs peripheral compartment culture samples of Enterococcus faecalis Ef1497 MutM3 in two-compartment pharmacokinetic/pharmacodynamic model assessed as effect on bacterial count at 600 mg, bid administered as 0.5 hr infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID1770347 | Antibacterial activity against clinical isolate Staphylococcus aureus C1 assessed as inhibition of bacterial growth measured after 20 hrs by two-fold microdilution assay | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Modification of 5-methylphenanthridium from benzothiazoles to indoles as potent FtsZ inhibitors: Broadening the antibacterial spectrum toward vancomycin-resistant enterococci. |
| AID270149 | Antibacterial activity against gram positive methicillin-resistant Staphylococcus aureus OC 2878 | 2006 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 16, Issue:17 | Antibacterial activity of pyrrolopyridine-substituted oxazolidinones: synthesis and in vitro SAR of various C-5 acetamide replacements. |
| AID533752 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus SA040 after 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Cellular pharmacodynamics of the novel biaryloxazolidinone radezolid: studies with infected phagocytic and nonphagocytic cells, using Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Legionella pneumophila. |
| AID552830 | Antibacterial activity against methicillin-resistant Staphylococcus aureus | 2011 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1 | The discovery and structure-activity relationships leading to CE-156811, a difluorophenyl cyclopropyl fluoroether: a novel potent antibacterial analog derived from hygromycin A. |
| AID1472753 | In vivo anti-virulence activity against methicillin-resistant Staphylococcus aureus NRS271 infected in BALB/c mouse model assessed as reduction in bacterial load in heart at 0.4 mg bid for 4.5 days administered intraperitoneally 6 hrs post infection by se | 2018 | Journal of medicinal chemistry, 01-11, Volume: 61, Issue:1 | Novel Terminal Bipheny-Based Diapophytoene Desaturases (CrtN) Inhibitors as Anti-MRSA/VISR/LRSA Agents with Reduced hERG Activity. |
| AID577116 | ABBC (0 to 24 hrs) in Enterococcus faecalis Ef1497 MutM3 in two-compartment pharmacokinetic/pharmacodynamic model at 200 mg, bid administered as 0.5 hr infusion for 2 days | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID29427 | Oral bioavailability in rat (Sprague-Dawley) (male) (dose 10 mg/kg i.v.) | 2003 | Journal of medicinal chemistry, Jan-16, Volume: 46, Issue:2 | Identification of phenylisoxazolines as novel and viable antibacterial agents active against Gram-positive pathogens. |
| AID571804 | Antibacterial activity against Clostridium hypermegas by CLSI M11-A6 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates. |
| AID565760 | Antimicrobial activity against oxacillin-susceptible Staphylococcus aureus clinical isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID283614 | Antimicrobial activity against Enterococcus faecalis 9 with heterozygous 23S rRNA G2576U mutation | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | In vitro activity of the oxazolidinone RWJ-416457 against linezolid-resistant and -susceptible staphylococci and enterococci. |
| AID383555 | Antibacterial activity against Bacillus pumilus ATCC 14884 by broth microdilution technique | 2008 | European journal of medicinal chemistry, Apr, Volume: 43, Issue:4 | Synthesis and in vitro antibacterial activities of novel oxazolidinones. |
| AID319160 | Oral bioavailability in human | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7 | Linezolid (ZYVOX), the first member of a completely new class of antibacterial agents for treatment of serious gram-positive infections. |
| AID206787 | Inhibitory activity against MSSA | 1996 | Journal of medicinal chemistry, Sep-27, Volume: 39, Issue:20 | New directions in antibacterial research. |
| AID41285 | Inhibitory activity against Bacteroides fragilis | 1996 | Journal of medicinal chemistry, Sep-27, Volume: 39, Issue:20 | New directions in antibacterial research. |
| AID285141 | Antimicrobial activity against beta hemolytic Streptococcus group C by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID1168010 | Antibacterial activity against vancomycin-resistant Enterococcus faecium clinical isolate 5396 after overnight incubation by two-fold serial dilution method | 2014 | Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21 | Synthesis and biological evaluation of novel peptide BF2 as an antibacterial agent against clinical isolates of vancomycin-resistant enterococci. |
| AID577124 | Residual concentration at the end of the administration interval in two-compartment pharmacokinetic/pharmacodynamic model at 200 mg, bid administered as 0.5 hr infusion over 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID533946 | Antimicrobial activity against community acquired methicillin-resistant Staphylococcus aureus NRS192 after 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Cellular pharmacodynamics of the novel biaryloxazolidinone radezolid: studies with infected phagocytic and nonphagocytic cells, using Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Legionella pneumophila. |
| AID1168023 | Antibacterial activity against vancomycin-resistant Enterococcus faecium clinical isolate 5484 after overnight incubation by two-fold serial dilution method | 2014 | Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21 | Synthesis and biological evaluation of novel peptide BF2 as an antibacterial agent against clinical isolates of vancomycin-resistant enterococci. |
| AID1904915 | Antibacterial activity against methicillin-resistant Staphylococcus aureus NRS 119 incubated for 18 to 20 hrs by broth microdilution method | 2022 | European journal of medicinal chemistry, Apr-15, Volume: 234 | Exploring the structure-activity relationships of diphenylurea as an antibacterial scaffold active against methicillin- and vancomycin-resistant Staphylococcus aureus. |
| AID1434676 | Anti-bacterial activity against methicillin-susceptible Staphylococcus aureus CCARM 0204 by 2-fold microtiter broth dilution method | 2017 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 27, Issue:3 | Cadiolides J-M, antibacterial polyphenyl butenolides from the Korean tunicate Pseudodistoma antinboja. |
| AID1873889 | Antibacterial activity against Staphylococcus aureus ATCC 29213 incubated for 16 to 20 hrs using 10^6 CFU/ml bacterial inoculum by broth microdilution method | 2022 | European journal of medicinal chemistry, Aug-05, Volume: 238 | Design, synthesis and activity against drug-resistant bacteria evaluation of C-20, C-23 modified 5-O-mycaminosyltylonolide derivatives. |
| AID548744 | Antimicrobial activity against Vancomycin-nonsusceptible Enterococcus faecium assessed as percent susceptible isolate by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Activities of dalbavancin against a worldwide collection of 81,673 gram-positive bacterial isolates. |
| AID564832 | Bactericidal activity against methicillin-resistant coagulase-negative Staphylococcus sciuri after 24 hrs by plate counting method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID528724 | Antibacterial activity against Streptococcus oralis clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID1151761 | Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate 0612 in po dosed mouse systemic infection model | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID573148 | Antibacterial activity against penicillin-nonsusceptible Streptococcus viridans assessed as resistant isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID297959 | Antibacterial activity against Streptococcus pneumoniae 548 infected mouse lung infection model assessed as reduction in bacterial count at 40 mg/kg/day, po relative to control | 2007 | Journal of medicinal chemistry, Oct-04, Volume: 50, Issue:20 | Novel substituted (pyridin-3-yl)phenyloxazolidinones: antibacterial agents with reduced activity against monoamine oxidase A and increased solubility. |
| AID523790 | Antimicrobial activity against oxacillin-resistant Staphylococcus aureus assessed as inhibition of microbial growth at =< 0.25 ug/ml by CLSI method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative activities of TR-700 (torezolid) against staphylococcal blood isolates collected in Spain. |
| AID424758 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus MB2865 after 20 hrs by twofold serial broth dilution method in presence of 50% human serum | 2009 | Journal of natural products, May-22, Volume: 72, Issue:5 | Thiazomycins, thiazolyl peptide antibiotics from Amycolatopsis fastidiosa. |
| AID565488 | Ratio of MBC to MIC for methicillin-resistant Staphylococcus aureus | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro bactericidal activity of iclaprim in human plasma. |
| AID1421232 | Antibacterial activity against vancomycin-resistant Enterococcus faecium clinical isolates by broth liquid microdilution method | 2018 | European journal of medicinal chemistry, Oct-05, Volume: 158 | Synthesis and antibacterial activity evaluation of novel biaryloxazolidinone analogues containing a hydrazone moiety as promising antibacterial agents. |
| AID531573 | Antibacterial activity against Staphylococcus intermedius obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID581033 | Bacteriostatic activity against Staphylococcus epidermidis ATCC 23760 at 4 X MIC after 24 hrs by time-kill analysis | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Mode of action of Ranbezolid against staphylococci and structural modeling studies of its interaction with ribosomes. |
| AID756089 | Antibacterial activity against Enterococcus faecalis assessed as growth inhibition after 16 hrs by agar dilution method | 2013 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 23, Issue:13 | Synthesis and biological evaluation of novel benzoxazinyl-oxazolidinones as potential antibacterial agents. |
| AID576655 | Bactericidal activity against 24 hrs peripheral compartment culture samples of Enterococcus faecalis ATCC 29212 in two-compartment pharmacokinetic/pharmacodynamic model assessed as effect on bacterial count at 200 mg, bid administered as 0.5 hr infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID576650 | Bactericidal activity against 2 hrs peripheral compartment culture samples of Enterococcus faecalis ATCC 29212 in two-compartment pharmacokinetic/pharmacodynamic model assessed as effect on bacterial count at 200 mg, bid administered as 0.5 hr infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID410228 | Antibacterial activity against Pseudomonas aeruginosa at 128 ug/mL by broth micro dilution method | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24 | A facile synthesis, antibacterial, and antitubercular studies of some piperidin-4-one and tetrahydropyridine derivatives. |
| AID559364 | Antimicrobial activity against compound-resistant Coxiella burnetii isolate CP1 obtained from patient with acute Q fever infected in african green monkey Vero cells after 24 hrs by shell vial assay | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Bacteriostatic and bactericidal activities of tigecycline against Coxiella burnetii and comparison with those of six other antibiotics. |
| AID533010 | Antibacterial activity against vancomycin-intermediate Staphylococcus aureus BR1 phenotypic revertant after 24 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Improved antimicrobial activity of linezolid against vancomycin-intermediate Staphylococcus aureus. |
| AID1151731 | Antibacterial activity against Streptococcus anginosus | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID1312942 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus USA300 NRS384 clinical isolate after 20 hrs by broth microdilution method | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10 | Second-Generation Phenylthiazole Antibiotics with Enhanced Pharmacokinetic Properties. |
| AID244829 | Minimum inhibitory concentration against Staphylococcus aureus ATCC 25923 | 2004 | Bioorganic & medicinal chemistry letters, Aug-02, Volume: 14, Issue:15 | Synthesis and antibacterial activity of arylpiperazinyl oxazolidinones with diversification of the N-substituents. |
| AID477374 | Antibacterial activity against Enterococcus faecalis MTCC 439 after 24 hrs | 2009 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13 | Synthesis and antibacterial evaluation of isoxazolinyl oxazolidinones: Search for potent antibacterial. |
| AID1161216 | Antimicrobial activity against Staphylococcus aureus ATCC 33591 in septicemia mouse model assessed as mortality of host at 20 mg/kg administered intragastrically measured after 14 days relative to control | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | Synthesis, antibacterial activity, and biological evaluation of formyl hydroxyamino derivatives as novel potent peptide deformylase inhibitors against drug-resistant bacteria. |
| AID1474259 | Ratio of MBC50 to MIC50 for vancomycin-resistant Enterococcus faecium ATCC 700221 | 2017 | Journal of medicinal chemistry, 03-23, Volume: 60, Issue:6 | Phenylthiazole Antibacterial Agents Targeting Cell Wall Synthesis Exhibit Potent Activity in Vitro and in Vivo against Vancomycin-Resistant Enterococci. |
| AID285108 | Antimicrobial activity against viridans group Streptococcus mutans at 0.25 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID285153 | Antimicrobial activity against viridans group Streptococcus sanguinis by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID564808 | Antimicrobial activity against methicillin-resistant coagulase-negative Staphylococcus simulans after 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID289865 | Antibacterial activity against Staphylococcus aureus ATCC 29213 | 2007 | European journal of medicinal chemistry, Apr, Volume: 42, Issue:4 | Synthesis, SAR and antibacterial studies on novel chalcone oxazolidinone hybrids. |
| AID577110 | ABBC (0 to 24 hrs) in Staphylococcus aureus RN4220 in two-compartment pharmacokinetic/pharmacodynamic model at 600 mg, bid administered as 0.5 hr infusion for 2 days | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID775531 | Inhibition of CYP2D6 in human liver microsomes assessed as dextromethorphan O-demethylation after 20 mins by LC/MS/MS analysis | 2013 | European journal of medicinal chemistry, Nov, Volume: 69 | Synthesis and in vitro/in vivo antibacterial activity of oxazolidinones having thiocarbamate at C-5 on the A-ring and an amide- or urea-substituted [1,2,5]triazepane or [1,2,5]oxadiazepane as the C-ring. |
| AID308920 | Antibacterial activity against vancomycin-resistant Enterococcus faecium ATCC 700221 by broth microdilution method | 2007 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 17, Issue:18 | Synthesis and in vitro antibacterial activity of novel methylamino piperidinyl oxazolidinones. |
| AID524965 | Antibacterial activity against methicillin-resistant coagulase-negative unspeciated Staphylococcus clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Comparative surveillance study of telavancin activity against recently collected gram-positive clinical isolates from across the United States. |
| AID576887 | Ratio of Cmax to MIC for 12.5 hrs peripheral compartment culture samples of Enterococcus faecalis ATCC 29212 in two-compartment pharmacokinetic/pharmacodynamic model at 200 mg, bid administered as 0.5 hr infusion for 2 days | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID285121 | Antimicrobial activity against viridans group Streptococcus parasanguis at 0.25 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID1409848 | Antibacterial activity against vancomycin-intermediate Staphylococcus aureus Mu50 infected in BALB/c mouse assessed as reduction of bacterial burden in liver at 0.1 mg, ip bid administered at 12 hrs prior to bacterial infection dosed at 12 intervals for 4 | 2018 | ACS medicinal chemistry letters, Mar-08, Volume: 9, Issue:3 | Novel Staphyloxanthin Inhibitors with Improved Potency against Multidrug Resistant |
| AID284967 | Antimicrobial activity against Corynebacterium jeikeium at 0.12 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID560503 | Antimicrobial activity against SCCmec type II vancomycin-intermediate Staphylococcus aureus isolate 6zjsau7 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID541048 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 infected in Albino guiena pig assessed as decrease in planktonic bacterial counts in cage fluid at 25 mg/kg measured on day 4 postinfection | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Linezolid alone or combined with rifampin against methicillin-resistant Staphylococcus aureus in experimental foreign-body infection. |
| AID284972 | Antimicrobial activity against Corynebacterium pseudodiphtheriticum at 0.12 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID285155 | Antimicrobial activity against viridans group Streptococcus mutans by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID560575 | Bactericidal activity against vancomycin-resistant Enterococcus faecium ATCC 51559 expressing vanA gene assessed as change in bacterial count at 16 ug/ml by time-kill assay | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Impact of human serum albumin on oritavancin in vitro activity against enterococci. |
| AID1304844 | Induction of hemolysis in human RBC at 200 uM incubated for 1 hr | 2016 | Journal of medicinal chemistry, 04-28, Volume: 59, Issue:8 | Structure-Activity Relationships of a Diverse Class of Halogenated Phenazines That Targets Persistent, Antibiotic-Tolerant Bacterial Biofilms and Mycobacterium tuberculosis. |
| AID308925 | Antibacterial activity against multidrug-resistant Streptococcus pneumoniae ATCC 700904 by broth microdilution method | 2007 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 17, Issue:18 | Synthesis and in vitro antibacterial activity of novel methylamino piperidinyl oxazolidinones. |
| AID1168014 | Antibacterial activity against vancomycin-resistant Enterococcus faecium clinical isolate 27/16917 after overnight incubation by two-fold serial dilution method | 2014 | Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21 | Synthesis and biological evaluation of novel peptide BF2 as an antibacterial agent against clinical isolates of vancomycin-resistant enterococci. |
| AID278859 | Inhibition of metabolic activity in MG63 cells assessed as MTT reduction after 48 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Influence on mitochondria and cytotoxicity of different antibiotics administered in high concentrations on primary human osteoblasts and cell lines. |
| AID524953 | Antibacterial activity against methicillin-susceptible coagulase-negative Staphylococcus xylosus clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Comparative surveillance study of telavancin activity against recently collected gram-positive clinical isolates from across the United States. |
| AID533664 | Antimicrobial activity against Staphylococcus aureus RN1024-tms | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic characterization of Vga ABC proteins conferring reduced susceptibility to pleuromutilins in Staphylococcus aureus. |
| AID293838 | Antibacterial activity against methicillin-resistant Staphylococcus aureus MF535 | 2007 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6 | A new class of anti-MRSA and anti-VRE agents: preparation and antibacterial activities of indole-containing compounds. |
| AID1591552 | Induction of Bacillus subtilis FtsZ polymerization in presence of GTP at 5 ug/ml measured over 30 mins by microtiter plate-based light-scattering assay | 2019 | Bioorganic & medicinal chemistry, 07-15, Volume: 27, Issue:14 | Discovery of 1,3,4-oxadiazol-2-one-containing benzamide derivatives targeting FtsZ as highly potent agents of killing a variety of MDR bacteria strains. |
| AID531553 | Antibacterial activity against methicillin susceptible Staphylococcus aureus obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID1504965 | Antitubercular activity against Mycobacterium tuberculosis H37Rv measured after 7 days under aerobic condition by alamar blue assay | 2017 | ACS medicinal chemistry letters, Dec-14, Volume: 8, Issue:12 | Antitubercular Nitroimidazoles Revisited: Synthesis and Activity of the Authentic 3-Nitro Isomer of Pretomanid. |
| AID326287 | Antibacterial activity against methicillin-resistant Staphylococcus aureus 4342 at 4 hrs daily exposure for 1 day by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Comparative activities of daptomycin, linezolid, and tigecycline against catheter-related methicillin-resistant Staphylococcus bacteremic isolates embedded in biofilm. |
| AID560810 | Elimination half life in human adults with pulmonary tuberculosis at 600 mg administered twice daily for 7 days | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Population pharmacokinetics of linezolid in adults with pulmonary tuberculosis. |
| AID520008 | Antimicrobial activity against Staphylococcus aureus ATCC 29213 | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID1151769 | Antibacterial activity against vancomycin-sensitive/high-level gentamycin-resistant Enterococcus faecalis isolate HH22 in po dosed mouse systemic infection model | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID267723 | Antimicrobial activity against Haemophilus influenzae | 2006 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 16, Issue:13 | Synthesis and structure-activity studies of antibacterial oxazolidinones containing dihydrothiopyran or dihydrothiazine C-rings. |
| AID573888 | AUC (0 to 24 hrs) in CF-1 mouse at 10 mg/kg, sc | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | In vivo activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. |
| AID710138 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus | 2012 | Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22 | From triclosan toward the clinic: discovery of nonbiocidal, potent FabI inhibitors for the treatment of resistant bacteria. |
| AID1703708 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus NRS107 assessed as inhibition of bacterial growth measured after 18 to 20 hrs by CLSI protocol based broth microdilution method | 2020 | European journal of medicinal chemistry, Sep-15, Volume: 202 | Evaluation of N-phenyl-2-aminothiazoles for treatment of multi-drug resistant and intracellular Staphylococcus aureus infections. |
| AID1432972 | Selectivity index, ratio of IC50 for African green monkey Vero cells to MIC for Mycobacterium tuberculosis H37Rv | |||
| AID1151757 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis isolate EFL 4041 | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID206470 | The compound was evaluated for its anti-bacterial activity against methicillin susceptible Staphylococcus aureus | 1998 | Journal of medicinal chemistry, Dec-17, Volume: 41, Issue:26 | Nitrogen-carbon-linked (azolylphenyl)oxazolidinones with potent antibacterial activity against the fastidious gram-negative organisms Haemophilus influenzae and Moraxella catarrhalis. |
| AID368277 | Bactericidal activity against vancomycin-intermediate Staphylococcus aureus by microdilution technique | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vivo efficacy of ceftaroline (PPI-0903), a new broad-spectrum cephalosporin, compared with linezolid and vancomycin against methicillin-resistant and vancomycin-intermediate Staphylococcus aureus in a rabbit endocarditis model. |
| AID1852674 | Antibacterial activity against multidrug resistant Acinetobacter baumannii AYE assessed as inhibition of bacterial growth incubated for 24 hrs in M9-MOPS medium by twofold serial dilution method | |||
| AID383556 | Antibacterial activity against Bacillus cereus ATCC 11778 by broth microdilution technique | 2008 | European journal of medicinal chemistry, Apr, Volume: 43, Issue:4 | Synthesis and in vitro antibacterial activities of novel oxazolidinones. |
| AID562635 | Antimicrobial activity against Corynebacterium spp. assessed as susceptible isolates by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | In vitro activities of three new dihydrofolate reductase inhibitors against clinical isolates of gram-positive bacteria. |
| AID573871 | Antibacterial activity against penicillin-susceptible Streptococcus pneumoniae ATCC 6301 infected in sc dosed Swiss Webster mouse administered at 1 to 3 hrs post infection measured after 3 days | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | In vivo activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. |
| AID575043 | Cmin in patient plasma at 600 mg, iv or 600 mg, po administered every 12 hrs by HPLC | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Therapeutic drug monitoring of linezolid: a retrospective monocentric analysis. |
| AID244836 | Minimum inhibitory concentration against Staphylococcus pyogenes ATCC 8668 | 2004 | Bioorganic & medicinal chemistry letters, Aug-02, Volume: 14, Issue:15 | Synthesis and antibacterial activity of arylpiperazinyl oxazolidinones with diversification of the N-substituents. |
| AID1778092 | Antibacterial activity against Bacillus subtilis 168 assessed as inhibition of bacterial growth incubated for 18 hrs by broth microdilution method | |||
| AID533931 | Antimicrobial activity against linezolid-resistant methicillin-resistant Staphylococcus aureus NRS120 harboring G2576U mutation in peptidyl transferase centre by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains. |
| AID576419 | Volume of distribution at steady state in two-compartment pharmacokinetic/pharmacodynamic model at 800 mg, bid administered as 0.5 hrs infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID1553383 | Inhibition of CYP2D6 (unknown origin) | 2019 | Bioorganic & medicinal chemistry letters, 09-15, Volume: 29, Issue:18 | Incorporation of a chiral gem-disubstituted nitrogen heterocycle yields an oxazolidinone antibiotic with reduced mitochondrial toxicity. |
| AID571925 | Antimicrobial activity against Escherichia coli K-12 3-AG300 harboring AcrB-G616N mutant gene | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Site-directed mutagenesis reveals amino acid residues in the Escherichia coli RND efflux pump AcrB that confer macrolide resistance. |
| AID562388 | Antimicrobial activity against vancomycin-susceptible Enterococcus faecalis clinical isolates assessed as percent susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID576425 | Antibacterial activity against Staphylococcus aureus RN4220 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID522821 | Antibacterial activity against vancomycin-intermediate Staphylococcus aureus after 24 hrs by modified broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Antistaphylococcal activity of ACHN-490 tested alone and in combination with other agents by time-kill assay. |
| AID285128 | Antimicrobial activity against viridans group Streptococcus salivarius at 1 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID1778668 | Ratio of MBC to MIC against penicillin-susceptible Bacillus pumilus CMCC 63202 | 2021 | European journal of medicinal chemistry, Oct-05, Volume: 221 | Design, synthesis and evaluation of novel 9-arylalkyl-10-methylacridinium derivatives as highly potent FtsZ-targeting antibacterial agents. |
| AID245129 | Minimum inhibitory concentration against Staphylococcus aureus (strain A15090) in absence of calf serum | 2004 | Bioorganic & medicinal chemistry letters, Sep-20, Volume: 14, Issue:18 | Discovery of isoxazolinone antibacterial agents. Nitrogen as a replacement for the stereogenic center found in oxazolidinone antibacterials. |
| AID69617 | Antibacterial activity against Escherichia coli (EC1008 ) | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | Novel oxazolidinone-quinolone hybrid antimicrobials. |
| AID112685 | In vivo antibacterial activity against Staphylococcus aures strain UC 9213 administered perorally in mice | 1996 | Journal of medicinal chemistry, Feb-02, Volume: 39, Issue:3 | Synthesis and antibacterial activity of U-100592 and U-100766, two oxazolidinone antibacterial agents for the potential treatment of multidrug-resistant gram-positive bacterial infections. |
| AID522920 | Antibacterial activity against community-acquired methicillin-resistant panton-valentine leukocidin-positive Staphylococcus aureus isolate 815 after 24 hrs by modified broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Antistaphylococcal activity of ACHN-490 tested alone and in combination with other agents by time-kill assay. |
| AID1430398 | Antibacterial activity against Staphylococcus aureus 209P after 24 to 48 hrs by macro-broth dilution method | 2017 | Bioorganic & medicinal chemistry letters, 03-01, Volume: 27, Issue:5 | Methylsulfonyl benzothiazoles (MSBT) derivatives: Search for new potential antimicrobial and anticancer agents. |
| AID1304832 | Antibacterial activity against methicillin-resistant Staphylococcus aureus clinical isolate 2 incubated for 16 to 18 hrs by broth microdilution method | 2016 | Journal of medicinal chemistry, 04-28, Volume: 59, Issue:8 | Structure-Activity Relationships of a Diverse Class of Halogenated Phenazines That Targets Persistent, Antibiotic-Tolerant Bacterial Biofilms and Mycobacterium tuberculosis. |
| AID369443 | Antibacterial activity against penicillin-susceptible Streptococcus pneumoniae after 20 to 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vitro activity of telavancin against gram-positive clinical isolates recently obtained in Europe. |
| AID1350034 | Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate 5 incubated overnight by agar dilution method | 2018 | Journal of natural products, 02-23, Volume: 81, Issue:2 | Biomimetic Stereoselective Sulfa-Michael Addition Leads to Platensimycin and Platencin Sulfur Analogues against Methicillin-Resistant Staphylococcus aureus. |
| AID1887539 | Antibacterial activity against Staphylococcus aureus ATCC 29213 assessed as reduction in bacterial growth incubated for 16 to 18 hrs by broth microdilution method | 2022 | Journal of natural products, 10-28, Volume: 85, Issue:10 | Developing the Natural Prenylflavone Artocarpin from |
| AID530051 | Antimicrobial activity against Staphylococcus aureus 286607-R1 harboring wild type gyrB by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Discovery and characterization of QPT-1, the progenitor of a new class of bacterial topoisomerase inhibitors. |
| AID542687 | fAUC (24 hrs) in Bacillus anthracis infected in vitro hollow fiber PK/PD model at simulated dose of 800 mg administered every 24 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID1519268 | Antibacterial activity agianst vancomycin-resistant Enterococcus faecium | 2019 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 29, Issue:23 | Synthesis and antibacterial evaluation of novel oxazolidinone derivatives containing a piperidinyl moiety. |
| AID1778644 | Antibacterial activity against penicillin-susceptible Bacillus pumilus CMCC 63202 assessed as bacterial growth inhibition by broth dilution method | 2021 | European journal of medicinal chemistry, Oct-05, Volume: 221 | Design, synthesis and evaluation of novel 9-arylalkyl-10-methylacridinium derivatives as highly potent FtsZ-targeting antibacterial agents. |
| AID1883846 | Antibacterial activity against Mycobacterium tuberculosis H37Rv in acute Mtb infection BALB/c mouse model assessed as reduction in log10 CFU in lungs at 100 mg/kg, po for 3 weeks | 2022 | Journal of medicinal chemistry, 06-09, Volume: 65, Issue:11 | Tuberculosis Drug Discovery: Challenges and New Horizons. |
| AID564828 | Bactericidal activity against methicillin-resistant coagulase-negative Staphylococcus simulans after 24 hrs by plate counting method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID567454 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus CGK6 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Development of daptomycin nonsusceptibility with heterogeneous vancomycin-intermediate resistance and oxacillin susceptibility in methicillin-resistant Staphylococcus aureus during high-dose daptomycin treatment. |
| AID1451761 | Antibacterial activity against Staphylococcus aureus Newman infected in BALB/c mouse assessed as reduction of bacterial burden in liver at 0.4 mg, ip bid for 4.5 days administered 6 hrs post bacterial infection measured 108 hrs post infection relative to | 2017 | Journal of medicinal chemistry, 10-12, Volume: 60, Issue:19 | Novel Inhibitors of Staphyloxanthin Virulence Factor in Comparison with Linezolid and Vancomycin versus Methicillin-Resistant, Linezolid-Resistant, and Vancomycin-Intermediate Staphylococcus aureus Infections in Vivo. |
| AID68416 | Minimum inhibitory concentration (MIC) against Enterococcus faecium OC 3312 (VRE) | 2004 | Bioorganic & medicinal chemistry letters, Jun-21, Volume: 14, Issue:12 | The synthesis and antimicrobial evaluation of a new series of isoxazolinyl oxazolidinones. |
| AID308728 | Antibacterial activity against Streptococcus pyogenes C203 SP1-1 by micro-broth method | 2007 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 17, Issue:16 | Synthesis and SAR of novel conformationally-restricted oxazolidinones possessing gram-positive and fastidious gram-negative antibacterial activity. Part 1: Substituted pyrazoles. |
| AID1904923 | Antibacterial activity against Staphylococcus epidermidis NRS 101 incubated for 18 to 20 hrs by broth microdilution method | 2022 | European journal of medicinal chemistry, Apr-15, Volume: 234 | Exploring the structure-activity relationships of diphenylurea as an antibacterial scaffold active against methicillin- and vancomycin-resistant Staphylococcus aureus. |
| AID373847 | Antimicrobial activity against vancomycin-resistant Staphylococcus aureus 510 Hershey after 50 passages with Linezolid measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID205691 | Minimum inhibitory concentration against methicillin resistant Staphylococcus aureus OC 2878 | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | Synthesis and antibacterial activity of pyrroloaryl-substituted oxazolidinones. |
| AID1609281 | Antibacterial activity against vancomycin-resistant Staphylococcus aureus 12 after 18 to 20 hrs by CLSI-based broth microdilution assay | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Phenylthiazoles with nitrogenous side chain: An approach to overcome molecular obesity. |
| AID573889 | AUC (0 to 24 hrs) in CF-1 mouse at 10 mg/kg, po | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | In vivo activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. |
| AID284965 | Antimicrobial activity against Corynebacterium amycolatum at 0.25 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID206594 | In vitro antibacterial activity against Staphylococcus aureus 29213A (S.a.3) | 2003 | Bioorganic & medicinal chemistry letters, Nov-17, Volume: 13, Issue:22 | Synthesis and in vitro activity of novel isoxazolyl tetrahydropyridinyl oxazolidinone antibacterial agents. |
| AID609040 | Antibacterial activity against Bacillus cereus ATCC 11778 after 24 hrs by broth microdilution method | 2011 | European journal of medicinal chemistry, Jul, Volume: 46, Issue:7 | A regioselective synthesis of some new pyrazol-1'-ylpyrazolo[1,5-a]pyrimidines in aqueous medium and their evaluation as antimicrobial agents. |
| AID695447 | Cytotoxicity against human CHO cell line after 72 hrs | 2011 | Journal of medicinal chemistry, May-12, Volume: 54, Issue:9 | Selenophene-containing inhibitors of type IIA bacterial topoisomerases. |
| AID1303403 | Antibacterial activity against vancomycin-resistant Enterococcus faecium after 24 hrs by microdilution method | 2016 | Bioorganic & medicinal chemistry letters, 07-01, Volume: 26, Issue:13 | Identification of novel aminopiperidine derivatives for antibacterial activity against Gram-positive bacteria. |
| AID1873911 | Antibacterial activity against Streptococcus dysgalactiae incubated for 16 to 20 hrs by broth microdilution method | 2022 | European journal of medicinal chemistry, Aug-05, Volume: 238 | Design, synthesis and activity against drug-resistant bacteria evaluation of C-20, C-23 modified 5-O-mycaminosyltylonolide derivatives. |
| AID285046 | Antimicrobial activity against Enterococcus durans by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID285080 | Antimicrobial activity against viridans group Streptococcus bovis at 0.5 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID564817 | Bactericidal activity against methicillin-resistant coagulase-negative Staphylococcus hominis after 24 hrs by plate counting method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID1190639 | Antibacterial activity against Bacillus subtilis NCIM-2063 incubated for 24 hrs by two fold serial dilution method | 2015 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 25, Issue:4 | Biofilm inhibition of linezolid-like Schiff bases: synthesis, biological activity, molecular docking and in silico ADME prediction. |
| AID533957 | Antimicrobial activity against Listeria monocytogenes infected in THP1 cells assessed as log reduction in bacterial count after 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Cellular pharmacodynamics of the novel biaryloxazolidinone radezolid: studies with infected phagocytic and nonphagocytic cells, using Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Legionella pneumophila. |
| AID576642 | Bactericidal activity against 12 hrs peripheral compartment culture samples of Staphylococcus aureus RN4220 MutS2 in two-compartment pharmacokinetic/pharmacodynamic model assessed as effect on bacterial count at 600 mg, bid administered as 0.5 hr infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID522915 | Antibacterial activity against hospital-acquired methicillin-resistant Staphylococcus aureus isolate 1838 after 24 hrs by modified broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Antistaphylococcal activity of ACHN-490 tested alone and in combination with other agents by time-kill assay. |
| AID374001 | Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus 555 Hershey after 20 passages with quinupristin-dalfopristin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID297119 | Antibacterial activity against methicillin-resistant Staphylococcus aureus after 18 hrs by agar plate dilution method | 2007 | Journal of medicinal chemistry, Aug-23, Volume: 50, Issue:17 | Discovery of 1,4-dihydroxy-2-naphthoate [corrected] prenyltransferase inhibitors: new drug leads for multidrug-resistant gram-positive pathogens. |
| AID1446759 | Bactericidal activity against methicillin-resistant Staphylococcus aureus USA300 NRS384 clinical isolate after 18 hrs by broth microdilution method | 2017 | European journal of medicinal chemistry, Apr-21, Volume: 130 | Diphenylurea derivatives for combating methicillin- and vancomycin-resistant Staphylococcus aureus. |
| AID1888848 | Antibacterial activity against Staphylococcus aureus K1758 measured after 24 hrs by Muller Hinton broth based MTT assay | 2022 | Bioorganic & medicinal chemistry, 01-15, Volume: 54 | Potentiating the intracellular killing of Staphylococcus aureus by dihydroquinazoline analogues as NorA efflux pump inhibitor. |
| AID69193 | Minimum inhibitory concentration (MIC) against Escherichia coli OC 2530 (HS) | 2004 | Bioorganic & medicinal chemistry letters, Jun-21, Volume: 14, Issue:12 | The synthesis and antimicrobial evaluation of a new series of isoxazolinyl oxazolidinones. |
| AID541537 | Antimicrobial activity against vancomycin-resistant Enterococcus faecalis clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID1879694 | Antimycobacterial activity against PAS resistant Mycobacterium tuberculosis H37Rv harboring R49W mutant assessed as inhibition of bacterial growth measured after 2 weeks by microbroth dilution method | 2022 | European journal of medicinal chemistry, Mar-15, Volume: 232 | Synthesis and biological evaluation of orally active prodrugs and analogs of para-aminosalicylic acid (PAS). |
| AID387451 | Antibacterial activity against vancomycin-susceptible Enterococcus faecalis DRCC 034 | 2008 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 18, Issue:18 | Novel and potent oxazolidinone antibacterials featuring 3-indolylglyoxamide substituents. |
| AID522923 | Antibacterial activity against community-acquired methicillin-resistant panton-valentine leukocidin-positive Staphylococcus aureus isolate 1472 after 24 hrs by modified broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Antistaphylococcal activity of ACHN-490 tested alone and in combination with other agents by time-kill assay. |
| AID560581 | Bactericidal activity against vancomycin-resistant Enterococcus faecium ATCC 51559 expressing vanA gene assessed as change in bacterial count at 4 ug/ml by time-kill assay | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Impact of human serum albumin on oritavancin in vitro activity against enterococci. |
| AID1076834 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus ATCC 25923 assessed as growth inhibition after 18 hrs by broth microdilution method | 2014 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 24, Issue:6 | Discovery of novel bis-oxazolidinone compounds as potential potent and selective antitubercular agents. |
| AID1861535 | Volume of distribution in Wistar rat at 30 mg/kg, iv | 2022 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 71 | WCK 4034: A promising oxazolidinone for treating gram positive infections. |
| AID775547 | Antibacterial activity against Enterococcus faecalis SR1004 clinical isolate assessed as growth inhibition by broth microdilution method | 2013 | European journal of medicinal chemistry, Nov, Volume: 69 | Synthesis and in vitro/in vivo antibacterial activity of oxazolidinones having thiocarbamate at C-5 on the A-ring and an amide- or urea-substituted [1,2,5]triazepane or [1,2,5]oxadiazepane as the C-ring. |
| AID145139 | In vitro antibacterial activity against Mycobacterium tuberculosis strain H37Rv | 1996 | Journal of medicinal chemistry, Feb-02, Volume: 39, Issue:3 | Synthesis and antibacterial activity of U-100592 and U-100766, two oxazolidinone antibacterial agents for the potential treatment of multidrug-resistant gram-positive bacterial infections. |
| AID11426 | Cmax in male rat | 2003 | Bioorganic & medicinal chemistry letters, Jul-07, Volume: 13, Issue:13 | Synthesis and in vitro activity of new methylenepiperidinyl and methylenepyrrolidinyl oxazolidinone antibacterial agents. |
| AID1770340 | Antibacterial activity against penicillin-susceptible Bacillus pumilus CMCC63202 assessed as inhibition of bacterial growth measured after 20 hrs by two-fold microdilution assay | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Modification of 5-methylphenanthridium from benzothiazoles to indoles as potent FtsZ inhibitors: Broadening the antibacterial spectrum toward vancomycin-resistant enterococci. |
| AID533929 | Antimicrobial activity against linezolid-resistant methicillin-resistant Staphylococcus aureus NRS127 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains. |
| AID535262 | Antimicrobial activity against vancomycin resistant Staphylococcus aureus VRS-10 expressing SCCmec type 2 element by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | In vitro activity of ceftaroline against community-associated methicillin-resistant, vancomycin-intermediate, vancomycin-resistant, and daptomycin-nonsusceptible Staphylococcus aureus isolates. |
| AID245194 | In vitro minimum inhibitory concentration against Staphylococcus saprophyticus (ATCC 15305) | 2005 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 15, Issue:12 | Synthesis and antibacterial activity of novel (un)substituted benzotriazolyl oxazolidinone derivatives. |
| AID560366 | Antimicrobial activity against vancomycin-resistant Enterococcus faecium 1119175 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Impact of human serum albumin on oritavancin in vitro activity against enterococci. |
| AID458459 | Antimicrobial activity against Escherichia coli X580 at 2 mM after overnight incubation by agar diffusion method | 2010 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 20, Issue:3 | Syntheses and antibacterial activity studies of new oxazolidinones from nitroso Diels-Alder chemistry. |
| AID284993 | Antimicrobial activity against Enterococcus casseliflavus at 4 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID1514449 | Antitubercular activity against isoniazid-resistant Mycobacterium tuberculosis after 7 days by resazurin dye based colorimetric assay | 2019 | Bioorganic & medicinal chemistry letters, 01-01, Volume: 29, Issue:1 | Synthesis, antituberculosis studies and biological evaluation of new quinoline derivatives carrying 1,2,4-oxadiazole moiety. |
| AID1594359 | Antibacterial activity against methicillin-resistant Staphylococcus aureus USA300 NRS384 after 18 to 24 hrs by broth microdilution assay | 2019 | Bioorganic & medicinal chemistry, 05-01, Volume: 27, Issue:9 | Second-generation aryl isonitrile compounds targeting multidrug-resistant Staphylococcus aureus. |
| AID1395675 | Antibacterial activity against methicillin-resistant Staphylococcus aureus NRS119 after 18 hrs by broth microdilution assay | 2018 | European journal of medicinal chemistry, May-10, Volume: 151 | Phenylthiazoles with tert-Butyl side chain: Metabolically stable with anti-biofilm activity. |
| AID1474204 | Antibacterial activity against vancomycin-resistant Enterococcus faecium clinical isolates after 18 to 22 hrs by broth microdilution method | 2017 | Journal of medicinal chemistry, 03-23, Volume: 60, Issue:6 | Phenylthiazole Antibacterial Agents Targeting Cell Wall Synthesis Exhibit Potent Activity in Vitro and in Vivo against Vancomycin-Resistant Enterococci. |
| AID1395674 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus NRS107 after 18 hrs by broth microdilution assay | 2018 | European journal of medicinal chemistry, May-10, Volume: 151 | Phenylthiazoles with tert-Butyl side chain: Metabolically stable with anti-biofilm activity. |
| AID467836 | Antibacterial activity against Bacillus cereus MTCC 430 after 24 hrs by agar dilution method | 2009 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 19, Issue:23 | Novel 4-N-substituted aryl but-3-ene-1,2-dione derivatives of piperazinyloxazolidinones as antibacterial agents. |
| AID577130 | Mean residence time in two-compartment pharmacokinetic/pharmacodynamic model at 200 mg, bid administered as 0.5 hr infusion over 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID319154 | Toxicity in dog at 20 mg/kg for 30 days | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7 | Linezolid (ZYVOX), the first member of a completely new class of antibacterial agents for treatment of serious gram-positive infections. |
| AID1312941 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus USA200 NRS383 clinical isolate after 20 hrs by broth microdilution method | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10 | Second-Generation Phenylthiazole Antibiotics with Enhanced Pharmacokinetic Properties. |
| AID1591540 | Antibacterial activity against Staphylococcus aureus ATCC 25923 incubated for 24 hrs by CLSI protocol based broth microdilution method | 2019 | Bioorganic & medicinal chemistry, 07-15, Volume: 27, Issue:14 | Discovery of 1,3,4-oxadiazol-2-one-containing benzamide derivatives targeting FtsZ as highly potent agents of killing a variety of MDR bacteria strains. |
| AID533979 | Antimicrobial activity against linezolid-susceptible Staphylococcus aureus SA238 infected in THP1 cells after 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Cellular pharmacodynamics of the novel biaryloxazolidinone radezolid: studies with infected phagocytic and nonphagocytic cells, using Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Legionella pneumophila. |
| AID560376 | Selectivity ratio of MIC for Enterococcus faecalis ATCC 51299 in presence of 4% HSA to MIC for Enterococcus faecalis 51299 | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Impact of human serum albumin on oritavancin in vitro activity against enterococci. |
| AID576664 | Bactericidal activity against 24 hrs peripheral compartment culture samples of Enterococcus faecalis ATCC 29212 in two-compartment pharmacokinetic/pharmacodynamic model assessed as effect on bacterial count at 600 mg, bid administered as 0.5 hr infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID1161142 | Antimicrobial activity against Escherichia coli isolate 2 after 24 hrs by broth microdilution method | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | Synthesis, antibacterial activity, and biological evaluation of formyl hydroxyamino derivatives as novel potent peptide deformylase inhibitors against drug-resistant bacteria. |
| AID560582 | Bactericidal activity against vancomycin-resistant Enterococcus faecalis ATCC 51299 expressing vanB gene assessed as change in bacterial count at 4 ug/ml by time-kill assay | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Impact of human serum albumin on oritavancin in vitro activity against enterococci. |
| AID1703722 | Antibacterial activity against methicillin-resistant Staphylococcus epidermidis NRS101 assessed as inhibition of bacterial growth measured after 18 to 20 hrs by CLSI protocol based broth microdilution method | 2020 | European journal of medicinal chemistry, Sep-15, Volume: 202 | Evaluation of N-phenyl-2-aminothiazoles for treatment of multi-drug resistant and intracellular Staphylococcus aureus infections. |
| AID1400052 | Bactericidal activity against Streptococcus pneumoniae ATCC 6301 incubated for 24 hrs under aerobic condition by MABA | 2018 | Bioorganic & medicinal chemistry, 09-15, Volume: 26, Issue:17 | An antimycobacterial pleuromutilin analogue effective against dormant bacilli. |
| AID577096 | T>MIC in Enterococcus faecalis ATCC 29212 in two-compartment pharmacokinetic/pharmacodynamic model at 200 mg, bid administered as 0.5 hr infusion for 2 days | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID1361106 | Bactericidal activity against methicillin-resistant Staphylococcus aureus NRS119 clinical isolate preincubated for 20 hrs followed by TSA plating and measured after 18 hrs | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | N-(1,3,4-oxadiazol-2-yl)benzamide analogs, bacteriostatic agents against methicillin- and vancomycin-resistant bacteria. |
| AID540210 | Clearance in human after iv administration | 2008 | Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7 | Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. |
| AID571764 | Antimicrobial activity against Escherichia coli K-12 3-AG300 harboring acrB::rpsLneo mutant gene | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Site-directed mutagenesis reveals amino acid residues in the Escherichia coli RND efflux pump AcrB that confer macrolide resistance. |
| AID625288 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for jaundice | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID1058378 | Antimicrobial activity against vancomycin -resistant Enterococcus faecalis after 24 hrs by microdilution method | 2013 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 23, Issue:24 | Anti-tubercular agents. Part 8: synthesis, antibacterial and antitubercular activity of 5-nitrofuran based 1,2,3-triazoles. |
| AID1361103 | Bacteriostatic activity against vancomycin-intermediate Staphylococcus aureus NRS1 clinical isolate after 20 hrs by broth microdilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | N-(1,3,4-oxadiazol-2-yl)benzamide analogs, bacteriostatic agents against methicillin- and vancomycin-resistant bacteria. |
| AID595021 | Antibacterial activity against Enterococcus faecalis ATCC 29212 | 2011 | Bioorganic & medicinal chemistry letters, May-15, Volume: 21, Issue:10 | Synthesis and in vitro activity of novel 1,2,4-triazolo[4,3-a]pyrimidine oxazolidinone antibacterial agents. |
| AID67398 | In vitro antibacterial activity against Enterococcus faecalis C6301 (E. f. 1) | 2003 | Bioorganic & medicinal chemistry letters, Jul-07, Volume: 13, Issue:13 | Synthesis and in vitro activity of new methylenepiperidinyl and methylenepyrrolidinyl oxazolidinone antibacterial agents. |
| AID576436 | Bactericidal activity against 48 hrs peripheral compartment culture samples of Staphylococcus aureus RN4220 in two-compartment pharmacokinetic/pharmacodynamic model assessed as effect on bacterial count at 600 mg, bid administered as 0.5 hr infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID383565 | Antibacterial activity against Staphylococcus aureus ATCC 9144 by broth microdilution technique | 2008 | European journal of medicinal chemistry, Apr, Volume: 43, Issue:4 | Synthesis and in vitro antibacterial activities of novel oxazolidinones. |
| AID374004 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus 540 after 24 passages with daptomycin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID558481 | Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus 555 measured on day 10 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID1474216 | Bacteriostatic activity against vancomycin-resistant Enterococcus faecalis HM-201 assessed as reduction in CFU at 4 times MIC after after 24 hrs | 2017 | Journal of medicinal chemistry, 03-23, Volume: 60, Issue:6 | Phenylthiazole Antibacterial Agents Targeting Cell Wall Synthesis Exhibit Potent Activity in Vitro and in Vivo against Vancomycin-Resistant Enterococci. |
| AID1596555 | Antibacterial activity against vancomycin resistant Enterococcus faecalis ATCC 51299 assessed as reduction in bacterial cell growth incubated for 18 to 20 hrs by broth microdilution method | 2019 | European journal of medicinal chemistry, Aug-01, Volume: 175 | Lipophilic efficient phenylthiazoles with potent undecaprenyl pyrophosphatase inhibitory activity. |
| AID207215 | In vitro minimum inhibitory concentration against Staphylococcus aureus MRQR | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | New classes of antibacterial oxazolidinones with C-5, methylene O-linked heterocyclic side chains. |
| AID69130 | In vitro inhibitory activity against protein synthesis was determined by transcription/translation assay with Escherichia coli S30 Extract System. | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | Structure-activity relationship in the oxazolidinone-quinolone hybrid series: influence of the central spacer on the antibacterial activity and the mode of action. |
| AID1174906 | Antibacterial activity against methicillin-resistant Staphylococcus aureus MRSA F511 by broth microdilution method | 2014 | Bioorganic & medicinal chemistry, Dec-15, Volume: 22, Issue:24 | New potent antibacterials against Gram-positive multiresistant pathogens: effects of side chain modification and chirality in linezolid-like 1,2,4-oxadiazoles. |
| AID410112 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus 67-0 by NCCLS method | 2008 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 18, Issue:23 | Design at the atomic level: design of biaryloxazolidinones as potent orally active antibiotics. |
| AID284975 | Antimicrobial activity against Corynebacterium pseudodiphtheriticum at 1 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID303962 | Antibacterial activity against vancomycin-resistant Enterococcus faecium by micro-broth technology | 2007 | Journal of medicinal chemistry, Nov-29, Volume: 50, Issue:24 | Antibacterial oxazolidinones possessing a novel C-5 side chain. (5R)-trans-3-[3-Fluoro-4- (1-oxotetrahydrothiopyran-4-yl)phenyl]-2- oxooxazolidine-5-carboxylic acid amide (PF-00422602), a new lead compound. |
| AID1233128 | Antibacterial activity against Enterococcus faecalis after 18 to 20 hrs by microbroth dilution method | 2015 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 25, Issue:13 | Thiol activated prodrugs of sulfur dioxide (SO2) as MRSA inhibitors. |
| AID562627 | Antimicrobial activity against Group B Streptococcus assessed as susceptible isolates by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | In vitro activities of three new dihydrofolate reductase inhibitors against clinical isolates of gram-positive bacteria. |
| AID520734 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus CM05 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Transcriptional and translational control of the mlr operon, which confers resistance to seven classes of protein synthesis inhibitors. |
| AID205561 | Minimum inhibitory concentration against Staphylococcus aureus ATCC 29213 | 2004 | Bioorganic & medicinal chemistry letters, Jun-21, Volume: 14, Issue:12 | Oxazolidinone: search for highly potent antibacterial. |
| AID577095 | T>MIC in Staphylococcus aureus RN4220 MutS2 in two-compartment pharmacokinetic/pharmacodynamic model at 600 mg, bid administered as 0.5 hr infusion for 2 days | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID1412974 | Antibacterial activity against Staphylococcus aureus ATCC 29213 after 16 hrs by agar dilution method | 2018 | MedChemComm, May-01, Volume: 9, Issue:5 | The semi-synthesis, biological evaluation and docking analysis of the oxime, hydrazine and hydrazide derivatives of platensimycin. |
| AID562169 | Antimicrobial activity against heterogeneous vancomycin-intermediate Staphylococcus aureus 168 after 50 passages by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID525133 | Antibacterial activity against Staphylococcus aureus KM52 after 18 to 24 hrs by broth microdilution method selected after 16 ug/ml drug exposure for 6 hrs by culture absorbance method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Delayed development of linezolid resistance in Staphylococcus aureus following exposure to low levels of antimicrobial agents. |
| AID604288 | Antibacterial activity against Staphylococcus aureus ATCC 13709 (Smith) after 16 to 24 hrs by twofold serial dilution method | 2011 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 21, Issue:14 | 7-Alkyl-N(2)-substituted-3-deazaguanines. Synthesis, DNA polymerase III inhibition and antibacterial activity. |
| AID560825 | fT>MIC in human adults with pulmonary tuberculosis at 600 mg administered once daily for 5 days | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Population pharmacokinetics of linezolid in adults with pulmonary tuberculosis. |
| AID318354 | Antibacterial activity against methicillin and macrolide-resistant Staphylococcus aureus | 2007 | Proceedings of the National Academy of Sciences of the United States of America, May-01, Volume: 104, Issue:18 | Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties. |
| AID581017 | Inhibition of protein synthesis in Staphylococcus epidermidis ATCC 23760 assessed as incorporation of [14C]isoleucine at 2 ug/ml by liquid scintillation counter | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Mode of action of Ranbezolid against staphylococci and structural modeling studies of its interaction with ribosomes. |
| AID1272267 | Antimicrobial activity against vancomycin-resistant Enterococcus faecalis MMX 486 expressing VanA after 18 to 20 hrs by microdilution method | 2016 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 26, Issue:3 | A stepwise dechlorination/cross-coupling strategy to diversify the vancomycin 'in-chloride'. |
| AID202107 | Inhibitory activity against Streptococcus pneumoniae UC9912 | 2000 | Journal of medicinal chemistry, Mar-09, Volume: 43, Issue:5 | Substituent effects on the antibacterial activity of nitrogen-carbon-linked (azolylphenyl)oxazolidinones with expanded activity against the fastidious gram-negative organisms Haemophilus influenzae and Moraxella catarrhalis. |
| AID563494 | Antibacterial activity against vancomycin-susceptible Enterococcus faecalis EF 12704 infected in New Zealand White rabbit assessed as log reduction of bacterial count in aortic valve vegetations at 10 mg/kg, administered through ear vein every 12 hrs for | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | In vivo activity of a novel anti-methicillin-resistant Staphylococcus aureus cephalosporin, ceftaroline, against vancomycin-susceptible and -resistant Enterococcus faecalis strains in a rabbit endocarditis model: a comparative study with linezolid and van |
| AID207009 | Antibacterial activity against ciprofloxacin resistant Staphylococcus aureus (SA1009 CipR) | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | Novel oxazolidinone-quinolone hybrid antimicrobials. |
| AID753126 | Antibacterial activity against Staphylococcus aureus MTCC 96 assessed as growth inhibition after 24 hrs by agar dilution method | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | Anti-tubercular agents. Part 7: a new class of diarylpyrrole-oxazolidinone conjugates as antimycobacterial agents. |
| AID1446751 | Bactericidal activity against Staphylococcus aureus RN4220 NRS107 clinical isolate after 18 hrs by broth microdilution method | 2017 | European journal of medicinal chemistry, Apr-21, Volume: 130 | Diphenylurea derivatives for combating methicillin- and vancomycin-resistant Staphylococcus aureus. |
| AID1649288 | Antibacterial activity against Vancomycin-resistant Enterococcus faecium SR7940 (VanA) assessed as inhibition of bacterial growth incubated for 20 hrs by microdilution broth method | |||
| AID555311 | Antibacterial activity against methicillin-resistant coagulase-negative Staphylococcus epidermidis 345 by broth macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Antistaphylococcal activity of dihydrophthalazine antifolates, a family of novel antibacterial drugs. |
| AID206511 | In vitro antibacterial activity against Staphylococcus hominis | 2003 | Bioorganic & medicinal chemistry letters, Jul-21, Volume: 13, Issue:14 | Synthesis and antibacterial activity of oxazolidinone containing sulphonyl group. |
| AID284961 | Antimicrobial activity against Corynebacterium spp. at 1 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID391592 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae PR44 by agar dilution method | 2008 | Journal of medicinal chemistry, Oct-23, Volume: 51, Issue:20 | Synthesis and structure-activity relationship studies of highly potent novel oxazolidinone antibacterials. |
| AID574067 | fCmax in CF-1 mouse at 10 mg/kg, sc | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | In vivo activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. |
| AID285129 | Antimicrobial activity against viridans group Streptococcus salivarius at 2 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID1271231 | Antibacterial activity against clinical isolate Neisseria meningitidis 184 by microbroth dilution method | 2015 | ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11 | Design, Synthesis, and Identification of Silicon Incorporated Oxazolidinone Antibiotics with Improved Brain Exposure. |
| AID295156 | Antibacterial activity against methicillin-susceptible Staphylococcus epidermidis by microdilution broth method | 2007 | European journal of medicinal chemistry, Aug, Volume: 42, Issue:8 | Synthesis and antibacterial activity of oxazolidinones containing triazolyl group. |
| AID561738 | Antibacterial activity against Beta-hemolytic Streptococcus group A assessed as resistant isolates by CLSI broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Potency and bactericidal activity of iclaprim against recent clinical gram-positive isolates. |
| AID1873906 | Antibacterial activity against Staphylococcus aureus ATCC 25923 incubated for 16 to 20 hrs by broth microdilution method | 2022 | European journal of medicinal chemistry, Aug-05, Volume: 238 | Design, synthesis and activity against drug-resistant bacteria evaluation of C-20, C-23 modified 5-O-mycaminosyltylonolide derivatives. |
| AID388048 | Antimicrobial activity against Candida albicans MY1055 after 18 to 20 hrs by serial dilution method | 2008 | Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19 | Isolation, structure, and antibacterial activity of thiazomycin A, a potent thiazolyl peptide antibiotic from Amycolatopsis fastidiosa. |
| AID558712 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus 547 measured on day 40 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID429416 | Antibacterial activity against Staphylococcus aureus ATCC 25923 by agar dilution method | 2009 | European journal of medicinal chemistry, Aug, Volume: 44, Issue:8 | Synthesis and antibacterial activity of novel 5-(4-methyl-1H-1,2,3-triazole) methyl oxazolidinones. |
| AID1168027 | Antibacterial activity against vancomycin-resistant Enterococcus faecium clinical isolate 13246 after overnight incubation by two-fold serial dilution method | 2014 | Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21 | Synthesis and biological evaluation of novel peptide BF2 as an antibacterial agent against clinical isolates of vancomycin-resistant enterococci. |
| AID577144 | Volume of distribution at steady state in two-compartment pharmacokinetic/pharmacodynamic model at 800 mg, bid administered as 0.5 hr infusion over 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID1770356 | Bactericidal activity against erythromycin-susceptible Staphylococcus aureus ATCC 25923 assessed as inhibition of bacterial growth measured after 20 hrs by two-fold microdilution assay | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Modification of 5-methylphenanthridium from benzothiazoles to indoles as potent FtsZ inhibitors: Broadening the antibacterial spectrum toward vancomycin-resistant enterococci. |
| AID585162 | Antibacterial activity against Mycobacterium smegmatis harboring 23S rRNA G2505A mutant after 24 generation times | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Mutations in 23S rRNA at the peptidyl transferase center and their relationship to linezolid binding and cross-resistance. |
| AID520223 | Antimicrobial activity against Enterococcus faecium A8948 | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID519079 | Antimicrobial activity wild type Escherichia coli SQ110 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Linezolid and tiamulin cross-resistance in Staphylococcus aureus mediated by point mutations in the peptidyl transferase center. |
| AID210379 | In vitro antibacterial activity against Streptococcus pneumoniae strain UC 9912 | 1996 | Journal of medicinal chemistry, Feb-02, Volume: 39, Issue:3 | Synthesis and antibacterial activity of U-100592 and U-100766, two oxazolidinone antibacterial agents for the potential treatment of multidrug-resistant gram-positive bacterial infections. |
| AID1117385 | Antimicrobial activity against Micrococcus luteus ATCC 10240 assessed as unclear inhibition zone at 37 degC for 24 hrs by agar diffusion method | 2010 | MedChemComm, Aug-01, Volume: 1, Issue:2 | Syntheses and biological evaluation of new cephalosporin-oxazolidinone conjugates. |
| AID559563 | Antimicrobial activity against compound-intermediate susceptible Coxiella burnetii isolate CP8 obtained from patient with acute Q fever infected in african green monkey Vero cells after 24 hrs by shell vial assay | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Bacteriostatic and bactericidal activities of tigecycline against Coxiella burnetii and comparison with those of six other antibiotics. |
| AID1079940 | Granulomatous liver disease, proven histopathologically. Value is number of references indexed. [column 'GRAN' in source] | |||
| AID1151747 | Antibacterial activity against Staphylococcus aureus measured after 9 serial passages | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID1168012 | Antibacterial activity against vancomycin-resistant Enterococcus faecium clinical isolate 31386 after overnight incubation by two-fold serial dilution method | 2014 | Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21 | Synthesis and biological evaluation of novel peptide BF2 as an antibacterial agent against clinical isolates of vancomycin-resistant enterococci. |
| AID559288 | Antimicrobial activity against recombination-deficient Enterococcus faecalis JH2-2 recA harboring nucleotides at position 2576 in rrlA 2576T, rrlB 2576G, rrlC 2576T and rrlD 2576T after 10, 11 passages under Linezolid selective pressure by agar dilution m | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Influence of recombination on development of mutational resistance to linezolid in Enterococcus faecalis JH2-2. |
| AID1710579 | Antibacterial activity against methicillin-resistant Staphylococcus aureus NRS385 assessed as inhibition of visible bacterial growth incubated for 18 to 20 hrs by CLSI method | 2020 | RSC medicinal chemistry, Jan-01, Volume: 11, Issue:1 | Potent trifluoromethoxy, trifluoromethylsulfonyl, trifluoromethylthio and pentafluorosulfanyl containing (1,3,4-oxadiazol-2-yl)benzamides against drug-resistant Gram-positive bacteria. |
| AID1760593 | Antibacterial activity against vancomycin resistant Enterococcus faecium 700221 assessed as inhibition of bacterial growth measured after 24 hrs | 2021 | European journal of medicinal chemistry, Feb-05, Volume: 211 | Installation of an aryl boronic acid function into the external section of N-aryl-oxazolidinones: Synthesis and antimicrobial evaluation. |
| AID524725 | Antibacterial activity against linezolid-resistant Enterococcus faecium 03B1075 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro antibacterial activity of CE-156811, a novel analog derived from hygromycin A. |
| AID1778646 | Antibacterial activity against erythromycin-susceptible Streptococcus pyogenes clinical isolate 1 assessed as bacterial growth inhibition incubated for 24 hrs by CLSI protocol based broth microdilution method | 2021 | European journal of medicinal chemistry, Oct-05, Volume: 221 | Design, synthesis and evaluation of novel 9-arylalkyl-10-methylacridinium derivatives as highly potent FtsZ-targeting antibacterial agents. |
| AID287258 | Antimicrobial activity against Staphylococcus aureus ATCC 25922 in presence of 50% human plasma by agar dilution method | 2007 | European journal of medicinal chemistry, Feb, Volume: 42, Issue:2 | Structure-antibacterial activity of arylcarbonyl- and arylsulfonyl-piperazine 5-triazolylmethyl oxazolidinones. |
| AID373991 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus 525 after 16 passages with quinupristin-dalfopristin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID542902 | Antimicrobial activity against Bacillus anthracis infected in in vitro hollow fiber PK/PD model assessed as bacterial regrowth at 100 mg administered once every 24 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID1451757 | Antibacterial activity against Staphylococcus aureus Newman infected in BALB/c mouse assessed as reduction of bacterial burden in heart at 0.4 mg, ip bid for 4.5 days treated 24 hrs prior to bacterial infection measured 108 hrs post infection relative to | 2017 | Journal of medicinal chemistry, 10-12, Volume: 60, Issue:19 | Novel Inhibitors of Staphyloxanthin Virulence Factor in Comparison with Linezolid and Vancomycin versus Methicillin-Resistant, Linezolid-Resistant, and Vancomycin-Intermediate Staphylococcus aureus Infections in Vivo. |
| AID201410 | Inhibitory activity against Methicillin-susceptible Staphylococcus aureus UC9213 | 2000 | Journal of medicinal chemistry, Mar-09, Volume: 43, Issue:5 | Substituent effects on the antibacterial activity of nitrogen-carbon-linked (azolylphenyl)oxazolidinones with expanded activity against the fastidious gram-negative organisms Haemophilus influenzae and Moraxella catarrhalis. |
| AID533937 | Antimicrobial activity against linezolid-resistant Staphylococcus aureus ATCC 29213 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains. |
| AID559778 | Antimicrobial activity against heterogeneous vancomycin-intermediate Staphylococcus aureus assessed as susceptible isolates by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID283159 | Antimicrobial susceptibility of Staphylococcus lugdunensis IDRL2526 biofilms after 24 hrs assessed as bacterial regrowth | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | In vitro effects of antimicrobial agents on planktonic and biofilm forms of Staphylococcus lugdunensis clinical isolates. |
| AID1250831 | Inhibition of Staphylococcus aureus FabI assessed as reduction in inhibition of reduction of trans-2-octenoyl N-acetylcysteamine substrate by spectrophotometry | 2015 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 25, Issue:20 | Discovery of a potent enoyl-acyl carrier protein reductase (FabI) inhibitor suitable for antistaphylococcal agent. |
| AID1393952 | Antibacterial activity against methicillin resistant Staphylococcus aureus ATCC 43300 after 16 to 20 hrs by CLSI method | 2018 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 28, Issue:16 | 3-Hydroxy-1,5-dihydro-2H-pyrrol-2-ones as novel antibacterial scaffolds against methicillin-resistant Staphylococcus aureus. |
| AID523783 | Antimicrobial activity against linezolid-resistant Staphylococcus aureus assessed as percent susceptible strain by CLSI method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative activities of TR-700 (torezolid) against staphylococcal blood isolates collected in Spain. |
| AID558529 | Antimicrobial activity against heterogeneous vancomycin-intermediate Staphylococcus aureus 168 measured on day 35 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID729225 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus after 16 hrs by NCCLS agar dilution method | 2013 | Journal of medicinal chemistry, Mar-28, Volume: 56, Issue:6 | Solubility-driven optimization of (pyridin-3-yl) benzoxazinyl-oxazolidinones leading to a promising antibacterial agent. |
| AID392203 | Antibacterial activity against Enterococcus faecalis MGH-2 EF1-1 by micro broth method | 2009 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 19, Issue:2 | Synthesis and structure-activity studies of novel homomorpholine oxazolidinone antibacterial agents. |
| AID522926 | Antibacterial activity against community-acquired methicillin-resistant panton-valentine leukocidin-positive Staphylococcus aureus isolate 813 after 24 hrs by modified broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Antistaphylococcal activity of ACHN-490 tested alone and in combination with other agents by time-kill assay. |
| AID541040 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 infected in Albino guiena pig assessed as no. of culture-negative cage fluid samples at 25 mg/kg measured on day 10 postinfection | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Linezolid alone or combined with rifampin against methicillin-resistant Staphylococcus aureus in experimental foreign-body infection. |
| AID67394 | In vitro antibacterial activity against Enterococcus faecalis 29212A (E.f.1) | 2003 | Bioorganic & medicinal chemistry letters, Nov-17, Volume: 13, Issue:22 | Synthesis and in vitro activity of novel isoxazolyl tetrahydropyridinyl oxazolidinone antibacterial agents. |
| AID1400058 | Bactericidal activity against Escherichia coli ATCC 10798 incubated for 24 hrs under aerobic condition by MABA | 2018 | Bioorganic & medicinal chemistry, 09-15, Volume: 26, Issue:17 | An antimycobacterial pleuromutilin analogue effective against dormant bacilli. |
| AID582986 | Antimicrobial activity against glycopeptide-resistant Enterococcus faecalis isolate HS0661 harboring MLST sequence type ST78 and pulsotype C expressing vanM gene cluster isolated from exudate of patient by Etest | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | vanM, a new glycopeptide resistance gene cluster found in Enterococcus faecium. |
| AID519075 | Antimicrobial activity mutS-expressing Staphylococcus aureus RN4220 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Linezolid and tiamulin cross-resistance in Staphylococcus aureus mediated by point mutations in the peptidyl transferase center. |
| AID541036 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 infected in Albino guiena pig assessed as no. of culture-negative cage fluid samples at 25 mg/kg measured on day 4 postinfection | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Linezolid alone or combined with rifampin against methicillin-resistant Staphylococcus aureus in experimental foreign-body infection. |
| AID439893 | Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate 2 after 18 hrs by agar dilution method | 2010 | European journal of medicinal chemistry, Jan, Volume: 45, Issue:1 | Synthesis and antibacterial activity of isothiazolyl oxazolidinones and analogous 3(2H)-isothiazolones. |
| AID558489 | Antimicrobial activity against heterogeneous vancomycin-intermediate Staphylococcus aureus 168 measured on day 15 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID726198 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis C474 by agar dilution method | 2013 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 23, Issue:5 | Synthesis and antibacterial activities of new piperidine substituted (5R)-[1,2,3]triazolylmethyl and (5R)-[(4-F-[1,2,3]triazolyl)methyl] oxazolidinones. |
| AID1435921 | Antibacterial activity against mupirocin/rifampicin-resistant Staphylococcus aureus RN4220 NRS107 clinical isolate after 18 to 20 hrs by broth microdilution method | 2017 | European journal of medicinal chemistry, Jan-27, Volume: 126 | Phenylthiazole antibiotics: A metabolism-guided approach to overcome short duration of action. |
| AID535029 | Antimicrobial activity against vancomycin intermediate Staphylococcus aureus NRS-68 expressing SCCmec type 2 element by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | In vitro activity of ceftaroline against community-associated methicillin-resistant, vancomycin-intermediate, vancomycin-resistant, and daptomycin-nonsusceptible Staphylococcus aureus isolates. |
| AID278858 | Antiproliferative effect against MG63 cells assessed as BrdU incorporation into DNA after 48 hrs after 48 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Influence on mitochondria and cytotoxicity of different antibiotics administered in high concentrations on primary human osteoblasts and cell lines. |
| AID1539448 | Antibacterial activity against Methicillin-resistant Staphylococcus aureus USA700-NRS386 clinical isolates after 18 to 20 hrs in aerobic condition by CLSI protocol based broth microdilution assay | |||
| AID1539441 | Antibacterial activity against methicillin-resistant Staphylococcus aureus NRS384-USA300 clinical isolates after 18 to 20 hrs in aerobic condition by CLSI protocol based broth microdilution assay | |||
| AID285022 | Antimicrobial activity against Listeria monocytogenes at 0.5 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID1594385 | Fraction absorbed in human at 625 mg, po | 2019 | Bioorganic & medicinal chemistry, 05-01, Volume: 27, Issue:9 | Second-generation aryl isonitrile compounds targeting multidrug-resistant Staphylococcus aureus. |
| AID1437029 | Antimycobacterial activity against isoniazid/rifampicin/kanamycin/streptomycin-resistant Mycobacterium tuberculosis by microplate Alamar Blue assay | 2017 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 27, Issue:4 | Development of gallic acid formazans as novel enoyl acyl carrier protein reductase inhibitors for the treatment of tuberculosis. |
| AID383562 | Antibacterial activity against multidrug-resistant Enterococcus faecalis ATCC 700802 by broth microdilution technique | 2008 | European journal of medicinal chemistry, Apr, Volume: 43, Issue:4 | Synthesis and in vitro antibacterial activities of novel oxazolidinones. |
| AID560821 | AUC (0 to 24 hrs) in human adults with pulmonary tuberculosis at 600 mg administered once daily for 5 days | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Population pharmacokinetics of linezolid in adults with pulmonary tuberculosis. |
| AID1596570 | Bactericidal activity against Listeria monocytogenes ATCC 19111 assessed as reduction in bacterial cell growth incubated for 18 to 20 hrs followed by re-plating on tryptic soy agar plates at 37 degC for 18 hrs by broth microdilution assay | 2019 | European journal of medicinal chemistry, Aug-01, Volume: 175 | Lipophilic efficient phenylthiazoles with potent undecaprenyl pyrophosphatase inhibitory activity. |
| AID297126 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis NCTC-12203 after 18 hrs by agar plate dilution method | 2007 | Journal of medicinal chemistry, Aug-23, Volume: 50, Issue:17 | Discovery of 1,4-dihydroxy-2-naphthoate [corrected] prenyltransferase inhibitors: new drug leads for multidrug-resistant gram-positive pathogens. |
| AID565013 | Antimicrobial activity against methicillin-susceptible coagulase-negative Staphylococcus simulans assessed as susceptible isolates after 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID1435934 | Bactericidal activity against vancomycin-resistant Staphylococcus aureus VRSA10 clinical isolate after 24 hrs | 2017 | European journal of medicinal chemistry, Jan-27, Volume: 126 | Phenylthiazole antibiotics: A metabolism-guided approach to overcome short duration of action. |
| AID424422 | Antibacterial activity against vancomycin-resistant Staphylococcus aureus HIP15178 isolated from patients surgical wound by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Vancomycin-resistant Staphylococcus aureus isolates associated with Inc18-like vanA plasmids in Michigan. |
| AID278928 | Antibacterial activity against Mycoplasma pneumoniae | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | In vitro antibacterial activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. |
| AID576654 | Bactericidal activity against 14 hrs peripheral compartment culture samples of Enterococcus faecalis ATCC 29212 in two-compartment pharmacokinetic/pharmacodynamic model assessed as effect on bacterial count at 200 mg, bid administered as 0.5 hr infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID439891 | Antibacterial activity against Salmonella Typhimurium ATCC 1639 after 18 hrs by agar dilution method | 2010 | European journal of medicinal chemistry, Jan, Volume: 45, Issue:1 | Synthesis and antibacterial activity of isothiazolyl oxazolidinones and analogous 3(2H)-isothiazolones. |
| AID1058366 | Antimicrobial activity against Mycobacterium tuberculosis H37Rv after 3 weeks by broth dilution method | 2013 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 23, Issue:24 | Anti-tubercular agents. Part 8: synthesis, antibacterial and antitubercular activity of 5-nitrofuran based 1,2,3-triazoles. |
| AID1504616 | Antibacterial activity against Staphylococcus aureus ATCC 6538P by microbroth dilution method | 2017 | ACS medicinal chemistry letters, Nov-09, Volume: 8, Issue:11 | Design, Synthesis, and Antibacterial Evaluation of Oxazolidinones with Fused Heterocyclic C-Ring Substructure. |
| AID284992 | Antimicrobial activity against Enterococcus casseliflavus at 2 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID542705 | fAUC (24 hrs) in Bacillus anthracis infected in vitro hollow fiber PK/PD model at simulated dose of 500 mg /day administered as 6 divided doses every 4 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID522883 | Antibacterial activity against vancomycin-resistant Staphylococcus aureus isolate 509 after 24 hrs by modified broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Antistaphylococcal activity of ACHN-490 tested alone and in combination with other agents by time-kill assay. |
| AID1374183 | Bacteriostatic activity against Staphylococcus aureus ATCC 25923 at 1 times MIC incubated for 24 hrs by time kill curve assay | 2018 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4 | Design, synthesis and antibacterial evaluation of honokiol derivatives. |
| AID734685 | Antibacterial activity against Klebsiella planticola MTCC 530 at 20 ug/ml after 24 hrs by disk diffusion method | 2013 | European journal of medicinal chemistry, Apr, Volume: 62 | Synthesis, biological evaluation of new oxazolidino-sulfonamides as potential antimicrobial agents. |
| AID374016 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus 490 after single-step resistance selection by agar dilution CLSI method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID326516 | Cmin in Enterococcus faecalis infected Wistar rat at 600 mg, po four consecutive administration every 12 hrs | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Single-dose oral amoxicillin or linezolid for prophylaxis of experimental endocarditis due to vancomycin-susceptible and vancomycin-resistant Enterococcus faecalis. |
| AID428283 | Antituberculosis activity against linezolid-resistant Mycobacterium tuberculosis having mutation in 23S rRNA with alteration in domain V | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro-selected linezolid-resistant Mycobacterium tuberculosis mutants. |
| AID1076819 | Antitubercular activity against extensive drug-resistant Mycobacterium tuberculosis clinical isolate 6 assessed as growth inhibition by microdilution method | 2014 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 24, Issue:6 | Discovery of novel bis-oxazolidinone compounds as potential potent and selective antitubercular agents. |
| AID710136 | Antibacterial activity against methicillin-resistant Staphylococcus haemolyticus | 2012 | Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22 | From triclosan toward the clinic: discovery of nonbiocidal, potent FabI inhibitors for the treatment of resistant bacteria. |
| AID131336 | Dose (administered orally) required to protect the Staphylococcus aureus infected mice was determined | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | Synthesis and biological evaluation of benzazepine oxazolidinone antibacterials. |
| AID206448 | In vitro antibacterial activity against methicillin susceptible Staphylococcus aureus UC19213 (MSSA); (SA1) | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | The effect of remote chirality on the antibacterial activity of indolinyl, tetrahydroquinolyl and dihydrobenzoxazinyl oxazolidinones. |
| AID533662 | Antimicrobial activity against Staphylococcus aureus RN4220 harboring vgaAv positive plasmid CU1 | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic characterization of Vga ABC proteins conferring reduced susceptibility to pleuromutilins in Staphylococcus aureus. |
| AID763946 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after 18 hrs by NCCLS agar dilution method in presence of human plasma | 2013 | European journal of medicinal chemistry, Aug, Volume: 66 | Synthesis and antibacterial activities of N-substituted-glycinyl 1H-1,2,3-triazolyl oxazolidinones. |
| AID444261 | Antibacterial activity against methicillin-resistant Staphylococcus aureus 33 by NCCLS method | 2009 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 19, Issue:22 | Synthesis and biological activity of novel oxazolidinones. |
| AID533117 | Antimicrobial activity against Staphylococcus aureus 10*3d1 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Serial daptomycin selection generates daptomycin-nonsusceptible Staphylococcus aureus strains with a heterogeneous vancomycin-intermediate phenotype. |
| AID388042 | Antibacterial activity against vancomycin-susceptible Enterococcus faecalis CL8516 after 18 to 20 hrs by serial dilution method | 2008 | Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19 | Isolation, structure, and antibacterial activity of thiazomycin A, a potent thiazolyl peptide antibiotic from Amycolatopsis fastidiosa. |
| AID285057 | Antimicrobial activity against beta hemolytic Streptococcus group C at 1 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID1609286 | Antibacterial activity against methicilline-resistant Staphylococcus aureus NRS123 USA400 after 18 to 20 hrs by CLSI-based broth microdilution assay | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Phenylthiazoles with nitrogenous side chain: An approach to overcome molecular obesity. |
| AID569343 | Antibacterial activity against methicillin-resistant Staphylococcus aureus by agar dilution method | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 | Design, synthesis and antibacterial activity of 3-methylenepyrrolidine formyl hydroxyamino derivatives as novel peptide deformylase inhibitors. |
| AID349317 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae after 18 hrs by agar dilution method | 2008 | European journal of medicinal chemistry, May, Volume: 43, Issue:5 | Synthesis and structure-antibacterial activity of triazolyl oxazolidinones containing long chain acyl moiety. |
| AID303958 | Inhibition of protein synthesis in Escherichia coli by cell-free transcription-translation assay | 2007 | Journal of medicinal chemistry, Nov-29, Volume: 50, Issue:24 | Antibacterial oxazolidinones possessing a novel C-5 side chain. (5R)-trans-3-[3-Fluoro-4- (1-oxotetrahydrothiopyran-4-yl)phenyl]-2- oxooxazolidine-5-carboxylic acid amide (PF-00422602), a new lead compound. |
| AID285094 | Antimicrobial activity against viridans group Streptococcus intermedius at <= 0.06 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID348860 | Antibacterial activity against vancomycin-resistant Enterococcus 1 after 18 to 20 hrs by agar dilution method | 2008 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 18, Issue:21 | Synthesis and antibacterial activities of novel oxazolidinones having cyclic sulfonamide moieties. |
| AID372666 | Antimicrobial activity against Salmonella typhi MTCC 733 after 24 hrs by agar dilution assay | 2009 | European journal of medicinal chemistry, Apr, Volume: 44, Issue:4 | Synthesis and antibacterial activity of some new 2,3-dimethoxy-3-hydroxy-2-(1-phenyl-3-aryl-4-pyrazolyl)chromanones. |
| AID560580 | Bactericidal activity against vancomycin-susceptible Enterococcus faecalis ATCC 29212 assessed as change in bacterial count at 4 ug/ml by time-kill assay | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Impact of human serum albumin on oritavancin in vitro activity against enterococci. |
| AID559284 | Antimicrobial activity against recombination-deficient Enterococcus faecalis JH2-2 recA harboring nucleotides at position 2576 in rrlA 2576G, rrlB 2576G, rrlC 2576G and rrlD 2576G by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Influence of recombination on development of mutational resistance to linezolid in Enterococcus faecalis JH2-2. |
| AID1493810 | Antibacterial activity against Acinetobacter baumannii ATCC 19606 after 20 hrs by broth microdilution method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Biphenylthiazole antibiotics with an oxadiazole linker: An approach to improve physicochemical properties and oral bioavailability. |
| AID558523 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus 525 measured on day 30 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID541061 | AUC (0 to 24 hrs) in cage fluid of Albino guiena pig at 75 mg/kg, ip | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Linezolid alone or combined with rifampin against methicillin-resistant Staphylococcus aureus in experimental foreign-body infection. |
| AID1304861 | Dissociation constant, pKa of compound | 2016 | Journal of medicinal chemistry, 04-28, Volume: 59, Issue:8 | Structure-Activity Relationships of a Diverse Class of Halogenated Phenazines That Targets Persistent, Antibiotic-Tolerant Bacterial Biofilms and Mycobacterium tuberculosis. |
| AID1434678 | Anti-bacterial activity against methicillin-susceptible Staphylococcus aureus CCARM 3640 by 2-fold microtiter broth dilution method | 2017 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 27, Issue:3 | Cadiolides J-M, antibacterial polyphenyl butenolides from the Korean tunicate Pseudodistoma antinboja. |
| AID209293 | Compound was evaluated for minimum inhibitory concentration against Streptococcus pyogenes 114 strain | 2002 | Bioorganic & medicinal chemistry letters, Mar-25, Volume: 12, Issue:6 | Synthesis and antibacterial activity of linezolid analogues. |
| AID625291 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver function tests abnormal | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID245153 | Minimum inhibitory concentration against Enterococcus faecalis UC9217; Range is 2-4 ug/mL | 2005 | Journal of medicinal chemistry, Jul-28, Volume: 48, Issue:15 | Conformational constraint in oxazolidinone antibacterials. Synthesis and structure-activity studies of (azabicyclo[3.1.0]hexylphenyl)oxazolidinones. |
| AID562384 | Antimicrobial activity against Enterococcus faecium clinical isolates assessed as percent susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID1151744 | Antibacterial activity against Staphylococcus aureus measured after 6 serial passages | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID528713 | Antibacterial activity against methicillin resistant coagulase-negative Staphylococcus haemolyticus clinical isolate assessed as susceptibility level by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID560826 | Cmax in human adults with pulmonary tuberculosis at 600 mg administered twice daily for 5 days | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Population pharmacokinetics of linezolid in adults with pulmonary tuberculosis. |
| AID387458 | AUC (0 to t) in Swiss albino mouse at 10 mg/kg, po | 2008 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 18, Issue:18 | Novel and potent oxazolidinone antibacterials featuring 3-indolylglyoxamide substituents. |
| AID535028 | Antimicrobial activity against vancomycin intermediate Staphylococcus aureus NRS-51 expressing SCCmec type 2 element by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | In vitro activity of ceftaroline against community-associated methicillin-resistant, vancomycin-intermediate, vancomycin-resistant, and daptomycin-nonsusceptible Staphylococcus aureus isolates. |
| AID1395707 | Bactericidal activity against methicillin-resistant Staphylococcus aureus NRS384 USA300 incubated fo 18 hrs followed by re-plating on tryptic soy agar plates at 37 degC for 18 hrs by broth microdilution assay | 2018 | European journal of medicinal chemistry, May-10, Volume: 151 | Phenylthiazoles with tert-Butyl side chain: Metabolically stable with anti-biofilm activity. |
| AID1680049 | Antibacterial activity against carbapenem-resistant Klebsiella pneumoniae clinical isolate 7 assessed as reduction in bacterial growth incubated for 16 to 20 hrs by CLSI-based broth microdilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Synthesis and antibacterial bioactivities of cationic deacetyl linezolid amphiphiles. |
| AID565081 | Antibacterial activity against hospital-acquired methicillin-resistant Staphylococcus aureus 152 by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Pharmacodynamic profile of tigecycline against methicillin-resistant Staphylococcus aureus in an experimental pneumonia model. |
| AID1327109 | Antibacterial activity against Pseudomonas aeruginosa NCIM 2036 at 10 ug/ml measured after 8 hrs by spectrophotometric method | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Design, synthesis and biological evaluation of novel azaspiro analogs of linezolid as antibacterial and antitubercular agents. |
| AID1680056 | Antibacterial activity against methicillin-resistant Staphylococcus aureus clinical isolate 9 assessed as reduction in bacterial growth incubated for 16 to 20 hrs by CLSI-based broth microdilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Synthesis and antibacterial bioactivities of cationic deacetyl linezolid amphiphiles. |
| AID567486 | Antimicrobial activity against vancomycin pretreated vancomycin-intermediate Staphylococcus aureus isolate 1 obtained from wound of patient by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Clinical outcomes by methicillin-resistant Staphylococcus aureus staphylococcal cassette chromosome mec type: isolates recovered from a phase IV clinical trial of linezolid and vancomycin for complicated skin and skin structure infections. |
| AID559792 | Antimicrobial activity against heterogeneous vancomycin-intermediate Staphylococcus aureus assessed as growth inhibition at 0.5 times MIC | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID1539454 | Antibacterial activity against vancomycin-resistant Enterococcus faecium ATCC 700221 clinical isolates after 18 to 20 hrs in aerobic condition by CLSI-based broth microdilution assay | |||
| AID262228 | Antibacterial activity against Enterococcus faecalis ATCC 35550 | 2006 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 16, Issue:6 | Novel 4-N-substituted aryl pent-2-ene-1,4-dione derivatives of piperazinyloxazolidinones as antibacterials. |
| AID1501360 | Antibacterial activity against methicillin-resistant Staphylococcus aureus USA300 NRS384 after 20 hrs by broth microdilution assay | 2017 | European journal of medicinal chemistry, Oct-20, Volume: 139 | Arylthiazole antibiotics targeting intracellular methicillin-resistant Staphylococcus aureus (MRSA) that interfere with bacterial cell wall synthesis. |
| AID1852679 | Antibacterial activity against wild type Acinetobacter baumannii assessed as inhibition of bacterial growth | |||
| AID348598 | Antibacterial activity against Streptococcus pneumoniae C402 after 18 to 20 hrs by agar dilution method | 2008 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 18, Issue:21 | Synthesis and antibacterial activities of novel oxazolidinones having cyclic sulfonamide moieties. |
| AID429064 | Antiplasmodial activity after 72 hrs against Plasmodium falciparum 3D7 as Malstat LDH activity | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Telithromycin and quinupristin-dalfopristin induce delayed death in Plasmodium falciparum. |
| AID1770352 | Antibacterial activity against Vancomycin-resistant Enterococcus faecium ATCC 51559 assessed as inhibition of bacterial growth measured after 20 hrs by two-fold microdilution assay | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Modification of 5-methylphenanthridium from benzothiazoles to indoles as potent FtsZ inhibitors: Broadening the antibacterial spectrum toward vancomycin-resistant enterococci. |
| AID285070 | Antimicrobial activity against beta hemolytic Streptococci group G at 2 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID549012 | Antimicrobial activity against Vancomycin-nonsusceptible Enterococcus faecalis assessed as percent resistant isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Activities of dalbavancin against a worldwide collection of 81,673 gram-positive bacterial isolates. |
| AID1723497 | Antibacterial activity against Enterococcus faecium NR-32052 incubated for 18 to 20 hrs under aerobic condition by CLSI protocol based broth microdilution assay | |||
| AID374007 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus 540 after 50 passages with vancomycin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID475008 | Antibacterial activity against Pseudomonas aeruginosa LCB0013 by two fold serial dilution method | 2010 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 20, Issue:7 | Synthesis, crystal and antibacterial studies of diversely functionalized tetrahydropyridin-4-ol. |
| AID562631 | Antimicrobial activity against Group G Streptococcus assessed as susceptible isolates by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | In vitro activities of three new dihydrofolate reductase inhibitors against clinical isolates of gram-positive bacteria. |
| AID544824 | Antimicrobial activity against Staphylococcus aureus Xen 30 biofilm assessed as log10 CFU/cm'2 in bacterial count | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Effect of electrical current on the activities of antimicrobial agents against Pseudomonas aeruginosa, Staphylococcus aureus, and Staphylococcus epidermidis biofilms. |
| AID558525 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus 540 measured on day 30 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID1056358 | Antibacterial activity against Moraxella catarrhalis SR26840 clinical isolate assessed as parasite growth inhibition by CLSI broth microdilution method | 2013 | ACS medicinal chemistry letters, Nov-14, Volume: 4, Issue:11 | Potent oxazolidinone antibacterials with heteroaromatic C-ring substructure. |
| AID1677800 | Bactericidal activity against Staphylococcus aureus ATCC25923 assessed as reduction in number of colony forming units incubated for 24 hrs followed by re-plating and reincubation on tryptic soy agar plate for 24 hrs | 2020 | Bioorganic & medicinal chemistry, 11-01, Volume: 28, Issue:21 | Design, synthesis of novel 4,5-dihydroisoxazole-containing benzamide derivatives as highly potent FtsZ inhibitors capable of killing a variety of MDR Staphylococcus aureus. |
| AID535035 | Antimicrobial activity against vancomycin intermediate Staphylococcus aureus NRS-402 expressing SCCmec type 2 element by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | In vitro activity of ceftaroline against community-associated methicillin-resistant, vancomycin-intermediate, vancomycin-resistant, and daptomycin-nonsusceptible Staphylococcus aureus isolates. |
| AID1446750 | Antibacterial activity against Staphylococcus aureus RN4220 NRS107 clinical isolate after 20 hrs by broth microdilution method | 2017 | European journal of medicinal chemistry, Apr-21, Volume: 130 | Diphenylurea derivatives for combating methicillin- and vancomycin-resistant Staphylococcus aureus. |
| AID1076832 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus ATCC 6538 assessed as growth inhibition after 18 hrs by broth microdilution method | 2014 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 24, Issue:6 | Discovery of novel bis-oxazolidinone compounds as potential potent and selective antitubercular agents. |
| AID558502 | Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus 1287 measured on day 20 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID262230 | Antibacterial activity against Staphylococcus aureus ATCC 9144 | 2006 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 16, Issue:6 | Novel 4-N-substituted aryl pent-2-ene-1,4-dione derivatives of piperazinyloxazolidinones as antibacterials. |
| AID285023 | Antimicrobial activity against Listeria monocytogenes at 1 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID323806 | Reduction in bioluminescent methicillin-sensitive Staphylococcus aureus Xen29 in immunocompetent CD1 mouse with peritonitis at 100 mg/kg, po after 3 hrs relative to control | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Rapid bactericidal activity of daptomycin against methicillin-resistant and methicillin-susceptible Staphylococcus aureus peritonitis in mice as measured with bioluminescent bacteria. |
| AID528694 | Antibacterial activity against methicillin resistant Staphylococcus epidermidis ATCC 35984 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID326526 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis UCN41 challenged with ID90 bacterial size inoculum in Wistar rat assessed as infection at 600 mg, po four consecutive administration every 12 hrs | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Single-dose oral amoxicillin or linezolid for prophylaxis of experimental endocarditis due to vancomycin-susceptible and vancomycin-resistant Enterococcus faecalis. |
| AID576433 | Bactericidal activity against 13 hrs peripheral compartment culture samples of Staphylococcus aureus RN4220 in two-compartment pharmacokinetic/pharmacodynamic model assessed as effect on bacterial count at 600 mg, bid administered as 0.5 hr infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID373988 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus 525 after 14 passages with CG400549 measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID583880 | Antibacterial activity against laboratory-derived Staphylococcus aureus isolate 29213-2 harboring ribosomal protein L3 Gly155Arg/Met169Leu mutant and cfr-containing p42262 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Elevated linezolid resistance in clinical cfr-positive Staphylococcus aureus isolates is associated with co-occurring mutations in ribosomal protein L3. |
| AID1139105 | Antimicrobial activity against Staphylococcus aureus ATCC 29213 | 2014 | Bioorganic & medicinal chemistry letters, May-01, Volume: 24, Issue:9 | Successful application of serum shift prediction models to the design of dual targeting inhibitors of bacterial gyrase B and topoisomerase IV with improved in vivo efficacy. |
| AID511437 | Antimicrobial activity against flo gene positive Escherichia coli | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Resistance to linezolid in a porcine Clostridium perfringens strain carrying a mutation in the rplD gene encoding the ribosomal protein L4. |
| AID548254 | Antibacterial activity against vancomycin-susceptible Staphylococcus aureus Mu50omega after 24 hrs by Etest | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Contribution of vraSR and graSR point mutations to vancomycin resistance in vancomycin-intermediate Staphylococcus aureus. |
| AID1409846 | Antibacterial activity against vancomycin-intermediate Staphylococcus aureus Mu50 infected in BALB/c mouse assessed as reduction of bacterial burden in liver at 0.1 mg, ip bid for 3.5 days administered 6 hrs post bacterial infection measured 84 hrs post i | 2018 | ACS medicinal chemistry letters, Mar-08, Volume: 9, Issue:3 | Novel Staphyloxanthin Inhibitors with Improved Potency against Multidrug Resistant |
| AID574552 | Decrease in delta toxin levels in Staphylococcus aureus USA300 at subinhibitory concentrations after 24 hrs by RP-HPLC/ESI- MS | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Subinhibitory concentrations of protein synthesis-inhibiting antibiotics promote increased expression of the agr virulence regulator and production of phenol-soluble modulin cytolysins in community-associated methicillin-resistant Staphylococcus aureus. |
| AID562189 | Antimicrobial activity against heterogeneous vancomycin-intermediate Staphylococcus aureus 873 measured after 10 antibiotic-free subculturing by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID1677808 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC43300 incubated for 24 hrs by CLSI-based broth microdilution method | 2020 | Bioorganic & medicinal chemistry, 11-01, Volume: 28, Issue:21 | Design, synthesis of novel 4,5-dihydroisoxazole-containing benzamide derivatives as highly potent FtsZ inhibitors capable of killing a variety of MDR Staphylococcus aureus. |
| AID289864 | Antibacterial activity against Staphylococcus aureus ATCC 49951 | 2007 | European journal of medicinal chemistry, Apr, Volume: 42, Issue:4 | Synthesis, SAR and antibacterial studies on novel chalcone oxazolidinone hybrids. |
| AID558727 | Antimicrobial activity against heterogeneous vancomycin-intermediate Staphylococcus aureus 168 measured on day 50 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID576661 | Bactericidal activity against 12.5 hrs peripheral compartment culture samples of Enterococcus faecalis ATCC 29212 in two-compartment pharmacokinetic/pharmacodynamic model assessed as effect on bacterial count at 600 mg, bid administered as 0.5 hr infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID542898 | fT>MIC in Bacillus anthracis infected in vitro hollow fiber PK/PD model at simulated dose of 200 mg administered every 12 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID730745 | Antibacterial activity against methicillin-resistant Staphylococcus aureus 1281-07 harboring cfr gene assessed as growth inhibition | 2013 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 23, Issue:6 | Novel 3-O-carbamoyl erythromycin A derivatives (carbamolides) with activity against resistant staphylococcal and streptococcal isolates. |
| AID572269 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus ATCC 49951 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vivo characterization of the peptide deformylase inhibitor LBM415 in murine infection models. |
| AID562247 | Antibacterial activity against methicillin-resistant Staphylococcus epidermidis ATCC 12228 by CLSI broth microdilution assay | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Mutations in ribosomal protein L3 are associated with oxazolidinone resistance in staphylococci of clinical origin. |
| AID1374173 | Antibacterial activity against Staphylococcus albus AS1.3374 incubated at 37 degC for 20 hrs by agar dilution method | 2018 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4 | Design, synthesis and antibacterial evaluation of honokiol derivatives. |
| AID645037 | Antibacterial activity against erythromycin-sensitive Streptococcus pyogenes 9 after 16 to 20 hrs by microbroth dilution method | 2012 | European journal of medicinal chemistry, Apr, Volume: 50 | Synthesis and preliminary antibacterial evaluation of Linezolid-like 1,2,4-oxadiazole derivatives. |
| AID1852693 | Antibacterial activity against Escherichia coli SQ110 DTC incubated for 24 hrs by twofold serial dilution method | |||
| AID533663 | Antimicrobial activity against Staphylococcus aureus RN1024 | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic characterization of Vga ABC proteins conferring reduced susceptibility to pleuromutilins in Staphylococcus aureus. |
| AID533960 | Antimicrobial activity against Staphylococcus epidermidis infected in THP1 cells after 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Cellular pharmacodynamics of the novel biaryloxazolidinone radezolid: studies with infected phagocytic and nonphagocytic cells, using Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Legionella pneumophila. |
| AID1180572 | Antimicrobial activity against Staphylococcus aureus ARC1692 by broth microdilution/CLSI method | 2014 | Journal of medicinal chemistry, Jul-24, Volume: 57, Issue:14 | Optimization of pyrrolamide topoisomerase II inhibitors toward identification of an antibacterial clinical candidate (AZD5099). |
| AID545815 | Antimicrobial activity against 4.6 X 10'6 CFU/peg methicillin-resistant Staphylococcus aureus ATCC 33591 planktonic cells by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Oritavancin kills stationary-phase and biofilm Staphylococcus aureus cells in vitro. |
| AID759683 | Cytotoxicity against porcine PK-15 cells assessed as reduction of cell viability at 5 to 400 ug/ml by MTT assay | 2013 | European journal of medicinal chemistry, Jul, Volume: 65 | New linezolid-like 1,2,4-oxadiazoles active against Gram-positive multiresistant pathogens. |
| AID1400048 | Antibacterial activity against Enterococcus faecalis ATCC 19433 incubated for 24 hrs under aerobic condition by MABA | 2018 | Bioorganic & medicinal chemistry, 09-15, Volume: 26, Issue:17 | An antimycobacterial pleuromutilin analogue effective against dormant bacilli. |
| AID1180580 | Antimicrobial activity against 2 times drug resistance selected Staphylococcus aureus ARC2398-2F by broth microdilution/CLSI method | 2014 | Journal of medicinal chemistry, Jul-24, Volume: 57, Issue:14 | Optimization of pyrrolamide topoisomerase II inhibitors toward identification of an antibacterial clinical candidate (AZD5099). |
| AID1361114 | Bactericidal activity against vancomycin-resistant Enterococcus faecium ATCC 700221 clinical isolate preincubated for 20 hrs followed by TSA plating and measured after 18 hrs | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | N-(1,3,4-oxadiazol-2-yl)benzamide analogs, bacteriostatic agents against methicillin- and vancomycin-resistant bacteria. |
| AID205560 | Minimum inhibitory concentration against Staphylococcus aureus ATCC 25923 | 2004 | Bioorganic & medicinal chemistry letters, Jun-21, Volume: 14, Issue:12 | Oxazolidinone: search for highly potent antibacterial. |
| AID1770367 | Bactericidal activity against Vancomycin-resistant Enterococcus faecalis ATCC 51299 assessed as inhibition of bacterial growth measured after 20 hrs by two-fold microdilution assay | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Modification of 5-methylphenanthridium from benzothiazoles to indoles as potent FtsZ inhibitors: Broadening the antibacterial spectrum toward vancomycin-resistant enterococci. |
| AID208626 | Antibacterial activity was determined against clinically isolated penicillin resistant Streptococcus pneumoniae (PRSP) strains (50 strains) | 2003 | Journal of medicinal chemistry, Mar-13, Volume: 46, Issue:6 | Synthesis and structure-activity relationships of 5-amino-6-fluoro-1-[(1R,2S)-2-fluorocyclopropan-1-yl]-8-methylquinolonecarboxylic acid antibacterials having fluorinated 7-[(3R)-3-(1-aminocyclopropan-1-yl)pyrrolidin-1-yl] substituents. |
| AID374019 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus 540 after single-step resistance selection by agar dilution CLSI method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID390323 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus 6538 | 2008 | Journal of natural products, Dec, Volume: 71, Issue:12 | Citreamicins with potent gram-positive activity. |
| AID1677807 | Antibacterial activity against Staphylococcus aureus ATCC25923 incubated for 24 hrs by CLSI-based broth microdilution method | 2020 | Bioorganic & medicinal chemistry, 11-01, Volume: 28, Issue:21 | Design, synthesis of novel 4,5-dihydroisoxazole-containing benzamide derivatives as highly potent FtsZ inhibitors capable of killing a variety of MDR Staphylococcus aureus. |
| AID1167991 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis clinical isolate 22626 after overnight incubation by two-fold serial dilution method | 2014 | Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21 | Synthesis and biological evaluation of novel peptide BF2 as an antibacterial agent against clinical isolates of vancomycin-resistant enterococci. |
| AID1472752 | In vivo anti-virulence activity against methicillin-resistant Staphylococcus aureus Mu50 infected in BALB/c mouse model assessed as reduction in bacterial load in heart at 0.4 mg bid for 4.5 days administered intraperitoneally 6 hrs post infection by seri | 2018 | Journal of medicinal chemistry, 01-11, Volume: 61, Issue:1 | Novel Terminal Bipheny-Based Diapophytoene Desaturases (CrtN) Inhibitors as Anti-MRSA/VISR/LRSA Agents with Reduced hERG Activity. |
| AID1680047 | Antibacterial activity against carbapenem-resistant Klebsiella pneumoniae clinical isolate 9 assessed as reduction in bacterial growth incubated for 16 to 20 hrs by CLSI-based broth microdilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Synthesis and antibacterial bioactivities of cationic deacetyl linezolid amphiphiles. |
| AID16465 | Calculated partition coefficient (clogP) | 1999 | Bioorganic & medicinal chemistry letters, Sep-20, Volume: 9, Issue:18 | 3D QSAR studies on new oxazolidinone antibacterial agents by comparative molecular field analysis. |
| AID424617 | Antibacterial activity against vancomycin-resistant Staphylococcus aureus AIS2006049 isolated from patients arm wound by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Vancomycin-resistant Staphylococcus aureus isolates associated with Inc18-like vanA plasmids in Michigan. |
| AID1168000 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis clinical isolate 27728 after overnight incubation by two-fold serial dilution method | 2014 | Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21 | Synthesis and biological evaluation of novel peptide BF2 as an antibacterial agent against clinical isolates of vancomycin-resistant enterococci. |
| AID292607 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus 562 by agar dilution method | 2007 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 17, Issue:17 | Synthesis and antibacterial activity of novel oxazolidinones with methylene oxygen- and methylene sulfur-linked substituents at C5-position. |
| AID292615 | Antimicrobial activity against Staphylococcus aureus ATCC 25923 by agar dilution method | 2007 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 17, Issue:17 | Synthesis and antibacterial activity of novel oxazolidinones with methylene oxygen- and methylene sulfur-linked substituents at C5-position. |
| AID559793 | Antimicrobial activity against heterogeneous vancomycin-intermediate Staphylococcus aureus assessed as growth inhibition at MIC | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID283624 | Antimicrobial activity against Enterococcus faecium 34 with homozygous 23S rRNA G2576U mutation | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | In vitro activity of the oxazolidinone RWJ-416457 against linezolid-resistant and -susceptible staphylococci and enterococci. |
| AID326502 | Antibacterial activity against vancomycin-susceptible Enterococcus faecalis 1209 after 24 hrs by broth macrodilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Single-dose oral amoxicillin or linezolid for prophylaxis of experimental endocarditis due to vancomycin-susceptible and vancomycin-resistant Enterococcus faecalis. |
| AID1611118 | Antibacterial activity against Staphylococcus aureus ATCC 29213 CLSI-based double dilution method | 2019 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 29, Issue:23 | Design and synthesis of biaryloxazolidinone derivatives containing amide or acrylamide moiety as novel antibacterial agents against Gram-positive bacteria. |
| AID577100 | T>MIC in Enterococcus faecalis Ef1497 MutM3 in two-compartment pharmacokinetic/pharmacodynamic model at 200 mg, bid administered as 0.5 hr infusion for 2 days | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID285054 | Antimicrobial activity against beta hemolytic Streptococcus group C at 0.12 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID576648 | Bactericidal activity against 0.5 hrs peripheral compartment culture samples of Enterococcus faecalis ATCC 29212 in two-compartment pharmacokinetic/pharmacodynamic model assessed as effect on bacterial count at 200 mg, bid administered as 0.5 hr infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID1861538 | Clearance in Wistar rat at 30 mg/kg, iv | 2022 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 71 | WCK 4034: A promising oxazolidinone for treating gram positive infections. |
| AID528709 | Antibacterial activity against penicillin resistant Streptococcus pneumoniae clinical isolate assessed as susceptibility level by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID1151762 | Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate 0605 in po dosed mouse systemic infection model | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID1446757 | Bactericidal activity against methicillin-resistant Staphylococcus aureus USA200 NRS383 clinical isolate after 18 hrs by broth microdilution method | 2017 | European journal of medicinal chemistry, Apr-21, Volume: 130 | Diphenylurea derivatives for combating methicillin- and vancomycin-resistant Staphylococcus aureus. |
| AID285107 | Antimicrobial activity against viridans group Streptococcus mutans at 0.12 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID745376 | Inhibition of human CYP2D6 assessed as dextromethorphan O-demethylation after 20 mins by LC/MS/MS analysis | 2013 | European journal of medicinal chemistry, May, Volume: 63 | Antibacterial oxazolidinone analogues having a N-hydroxyacetyl-substituted seven-membered [1,2,5]triazepane or [1,2,5]oxadiazepane C-ring unit. |
| AID326288 | Antibacterial activity against methicillin-resistant Staphylococcus aureus 293 at 4 hrs daily exposure for 1 day by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Comparative activities of daptomycin, linezolid, and tigecycline against catheter-related methicillin-resistant Staphylococcus bacteremic isolates embedded in biofilm. |
| AID573892 | fAUC (0 to 24 hrs) in CF-1 mouse at 10 mg/kg, po | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | In vivo activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. |
| AID734688 | Antibacterial activity against Staphylococcus aureus MTCC 96 at 20 ug/ml after 24 hrs by disk diffusion method | 2013 | European journal of medicinal chemistry, Apr, Volume: 62 | Synthesis, biological evaluation of new oxazolidino-sulfonamides as potential antimicrobial agents. |
| AID66901 | Antibacterial activity against Enterococcus faecalis UC9217 (E. f) | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | Synthesis and biological evaluation of benzazepine oxazolidinone antibacterials. |
| AID1852702 | Selectivity ratio of IC50 for OM pore producing Pseudomonas aeruginosa to IC50 for efflux pump lacking/OM pore producing Pseudomonas aeruginosa | |||
| AID1271216 | AUC (0 to infinity) in BALB/c mouse brain at 10 mg/kg, po by LC-MS/MS analysis | 2015 | ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11 | Design, Synthesis, and Identification of Silicon Incorporated Oxazolidinone Antibiotics with Improved Brain Exposure. |
| AID555325 | Antibacterial activity against methicillin-resistant Staphylococcus aureus 145 after 50 passages by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Antistaphylococcal activity of dihydrophthalazine antifolates, a family of novel antibacterial drugs. |
| AID1272266 | Antimicrobial activity against vancomycin-resistant Enterococcus faecalis MMX 202 expressing VanB after 18 to 20 hrs by microdilution method | 2016 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 26, Issue:3 | A stepwise dechlorination/cross-coupling strategy to diversify the vancomycin 'in-chloride'. |
| AID609158 | Antibacterial activity against Bacillus cereus ATCC 11778 at 1 mg/ml after 24 hrs by agar-well diffusion technique | 2011 | European journal of medicinal chemistry, Jul, Volume: 46, Issue:7 | A regioselective synthesis of some new pyrazol-1'-ylpyrazolo[1,5-a]pyrimidines in aqueous medium and their evaluation as antimicrobial agents. |
| AID576647 | Bactericidal activity against 48 hrs peripheral compartment culture samples of Staphylococcus aureus RN4220 MutS2 in two-compartment pharmacokinetic/pharmacodynamic model assessed as effect on bacterial count at 600 mg, bid administered as 0.5 hr infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID1350029 | Antibacterial activity against Staphylococcus aureus ATCC 29213 incubated overnight by agar dilution method | 2018 | Journal of natural products, 02-23, Volume: 81, Issue:2 | Biomimetic Stereoselective Sulfa-Michael Addition Leads to Platensimycin and Platencin Sulfur Analogues against Methicillin-Resistant Staphylococcus aureus. |
| AID566578 | Antimicrobial activity against Staphylococcus aureus ATCC 6538p by conventional agar-dilution method | 2011 | European journal of medicinal chemistry, Jan, Volume: 46, Issue:1 | Discovery of a novel nitroimidazolyl-oxazolidinone hybrid with potent anti Gram-positive activity: Synthesis and antibacterial evaluation. |
| AID575099 | Antimicrobial activity against Streptococcus pneumoniae serotype 15A assessed as percent susceptible isolates by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID498883 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus OC 4172 assessed as inhibition of growth by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vivo activity of ceftobiprole in murine skin infections due to Staphylococcus aureus and Pseudomonas aeruginosa. |
| AID1361120 | Bacteriostatic activity against Acinetobacter baumannii ATCC 19606 after 20 hrs by broth microdilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | N-(1,3,4-oxadiazol-2-yl)benzamide analogs, bacteriostatic agents against methicillin- and vancomycin-resistant bacteria. |
| AID574072 | Half life in CF-1 mouse at 2 mg/kg, iv | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | In vivo activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. |
| AID1596546 | Antibacterial activity against methicillin resistant Staphylococcus aureus NRS119 assessed as reduction in bacterial cell growth incubated for 18 to 20 hrs by broth microdilution method | 2019 | European journal of medicinal chemistry, Aug-01, Volume: 175 | Lipophilic efficient phenylthiazoles with potent undecaprenyl pyrophosphatase inhibitory activity. |
| AID206447 | In vitro antibacterial activity against methicillin susceptible Staphylococcus aureus UC 9213 (MSSA); range is 2-4 | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | The synthesis and antibacterial activity of 1,3,4-thiadiazole phenyl oxazolidinone analogues. |
| AID223270 | Dose required to cure 50% of Staphylococcus aureus infected mice in the presence of vancomycin when administered orally; value ranges from 2.5-6.4 | 2000 | Journal of medicinal chemistry, Mar-09, Volume: 43, Issue:5 | Substituent effects on the antibacterial activity of nitrogen-carbon-linked (azolylphenyl)oxazolidinones with expanded activity against the fastidious gram-negative organisms Haemophilus influenzae and Moraxella catarrhalis. |
| AID274223 | Antibacterial activity against Escherichia coli by transcription and translation assay | 2006 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 16, Issue:20 | Synthesis and structure-activity studies of novel benzocycloheptanone oxazolidinone antibacterial agents. |
| AID1677806 | Antibacterial activity against Bacillus pumilus CMCC63202 incubated for 24 hrs by CLSI-based broth microdilution method | 2020 | Bioorganic & medicinal chemistry, 11-01, Volume: 28, Issue:21 | Design, synthesis of novel 4,5-dihydroisoxazole-containing benzamide derivatives as highly potent FtsZ inhibitors capable of killing a variety of MDR Staphylococcus aureus. |
| AID566571 | Antimicrobial activity against Escherichia coli ATCC 8739 by conventional agar-dilution method | 2011 | European journal of medicinal chemistry, Jan, Volume: 46, Issue:1 | Discovery of a novel nitroimidazolyl-oxazolidinone hybrid with potent anti Gram-positive activity: Synthesis and antibacterial evaluation. |
| AID576649 | Bactericidal activity against 1 hr peripheral compartment culture samples of Enterococcus faecalis ATCC 29212 in two-compartment pharmacokinetic/pharmacodynamic model assessed as effect on bacterial count at 200 mg, bid administered as 0.5 hr infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID695442 | Antibacterial activity against fluoroquinolone resistant Staphylococcus aureus 1-FQR2M BK2384 expressing GyrA Ser84Leu mutant and GrlA Ser80Phe mutant | 2011 | Journal of medicinal chemistry, May-12, Volume: 54, Issue:9 | Selenophene-containing inhibitors of type IIA bacterial topoisomerases. |
| AID326521 | T>MIC in Enterococcus faecalis infected Wistar rat at 600 mg, po four consecutive administration every 12 hrs | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Single-dose oral amoxicillin or linezolid for prophylaxis of experimental endocarditis due to vancomycin-susceptible and vancomycin-resistant Enterococcus faecalis. |
| AID387453 | Antibacterial activity against vancomycin-resistant Enterococcus faecium DRCC 154 | 2008 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 18, Issue:18 | Novel and potent oxazolidinone antibacterials featuring 3-indolylglyoxamide substituents. |
| AID132090 | Tested for the dose to protect the mice from infection with Staphylococcus aureus OC 4172, by oral administration | 2004 | Bioorganic & medicinal chemistry letters, Jun-21, Volume: 14, Issue:12 | The synthesis and antimicrobial evaluation of a new series of isoxazolinyl oxazolidinones. |
| AID1873910 | Antibacterial activity against Enterococcus faecium incubated for 16 to 20 hrs by broth microdilution method | 2022 | European journal of medicinal chemistry, Aug-05, Volume: 238 | Design, synthesis and activity against drug-resistant bacteria evaluation of C-20, C-23 modified 5-O-mycaminosyltylonolide derivatives. |
| AID323812 | Reduction in bioluminescent methicillin-resistant Staphylococcus aureus Xen1 in neutropenic CD1 mouse with peritonitis at 100 mg/kg, po after 2 hrs relative to control | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Rapid bactericidal activity of daptomycin against methicillin-resistant and methicillin-susceptible Staphylococcus aureus peritonitis in mice as measured with bioluminescent bacteria. |
| AID349315 | Antibacterial activity against vancomycin-resistant Enterococcus after 18 hrs by agar dilution method | 2008 | European journal of medicinal chemistry, May, Volume: 43, Issue:5 | Synthesis and structure-antibacterial activity of triazolyl oxazolidinones containing long chain acyl moiety. |
| AID387457 | Antibacterial activity against Staphylococcus aureus DRCC 035 infected mouse systemic infection model administered orally for 1 day at 1 and 5 hrs post-infection and measured daily for 5 days | 2008 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 18, Issue:18 | Novel and potent oxazolidinone antibacterials featuring 3-indolylglyoxamide substituents. |
| AID523835 | Ratio of vancomycin MIC90 to compound MIC90 for linezolid-susceptible Staphylococcus aureus | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative activities of TR-700 (torezolid) against staphylococcal blood isolates collected in Spain. |
| AID528841 | Antimicrobial activity against penicillin-resistant Streptococcus pneumoniae isolated from ICU patient wound assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID559361 | Antimicrobial activity against compound-resistant Coxiella burnetii Q212 obtained from patient with acute Q fever infected in african green monkey Vero cells after 24 hrs by shell vial assay | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Bacteriostatic and bactericidal activities of tigecycline against Coxiella burnetii and comparison with those of six other antibiotics. |
| AID1414188 | Antibacterial activity against Bacillus subtilis ATCC 9372 after 24 hrs by broth microdilution based CLSI method | 2018 | European journal of medicinal chemistry, Nov-05, Volume: 159 | Design, synthesis and structure-based optimization of novel isoxazole-containing benzamide derivatives as FtsZ modulators. |
| AID1414192 | Antibacterial activity against clinical isolate of penicillin-resistant Staphylococcus aureus after 24 hrs by broth microdilution based CLSI method | 2018 | European journal of medicinal chemistry, Nov-05, Volume: 159 | Design, synthesis and structure-based optimization of novel isoxazole-containing benzamide derivatives as FtsZ modulators. |
| AID285356 | Decrease in Panton-Valentine leukocidin level in community acquired methicillin-resistant Staphylococcus aureus HT20040332 in CYY medium | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Effect of antibiotics on Staphylococcus aureus producing Panton-Valentine leukocidin. |
| AID522921 | Antibacterial activity against community-acquired methicillin-resistant panton-valentine leukocidin-positive Staphylococcus aureus isolate 950 after 24 hrs by modified broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Antistaphylococcal activity of ACHN-490 tested alone and in combination with other agents by time-kill assay. |
| AID390340 | Antimicrobial activity against Serratia marcescens 1635 | 2008 | Journal of natural products, Dec, Volume: 71, Issue:12 | Citreamicins with potent gram-positive activity. |
| AID293552 | Antibacterial activity against Staphylococcus epidermidis MTCC 2639 after 24 hrs by agar dilution assay | 2007 | European journal of medicinal chemistry, Jun, Volume: 42, Issue:6 | Organoiodine(III) mediated synthesis of 3,9-diaryl- and 3,9-difuryl-bis-1,2,4-triazolo[4,3-a][4,3-c]pyrimidines as antibacterial agents. |
| AID390327 | Antimicrobial activity against linezolid-resistant methicillin-resistant Staphylococcus aureus 1725 | 2008 | Journal of natural products, Dec, Volume: 71, Issue:12 | Citreamicins with potent gram-positive activity. |
| AID542677 | fCmax in Bacillus anthracis infected in vitro hollow fiber PK/PD model at simulated dose of 600 mg administered every 24 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID390329 | Antimicrobial activity against penicillin-susceptible Streptococcus pneumoniae 975 | 2008 | Journal of natural products, Dec, Volume: 71, Issue:12 | Citreamicins with potent gram-positive activity. |
| AID285372 | Antibacterial activity against vancomycin-resistant Enterococcus faecium ATCC 700221 by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Pharmacokinetic/pharmacodynamic factors influencing emergence of resistance to linezolid in an in vitro model. |
| AID352923 | Antibacterial activity against Enterococcus faecalis C474 after 18 to 20 hrs by agar dilution method | 2009 | Bioorganic & medicinal chemistry letters, May-01, Volume: 19, Issue:9 | Synthesis and antibacterial activities of novel oxazolidinones having spiro[2,4]heptane moieties. |
| AID1446752 | Antibacterial activity against methicillin-resistant Staphylococcus aureus USA400 NRS123 clinical isolate after 20 hrs by broth microdilution method | 2017 | European journal of medicinal chemistry, Apr-21, Volume: 130 | Diphenylurea derivatives for combating methicillin- and vancomycin-resistant Staphylococcus aureus. |
| AID206595 | In vitro antibacterial activity against Staphylococcus aureus 6538p (S.a.1) | 2003 | Bioorganic & medicinal chemistry letters, Nov-17, Volume: 13, Issue:22 | Synthesis and in vitro activity of novel isoxazolyl tetrahydropyridinyl oxazolidinone antibacterial agents. |
| AID373806 | Antimicrobial activity against vancomycin-resistant Staphylococcus aureus 510 Hershey after 50 passages by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID729223 | Antibacterial activity against methicillin-sensitive Staphylococcus epidermidis after 16 hrs by NCCLS agar dilution method | 2013 | Journal of medicinal chemistry, Mar-28, Volume: 56, Issue:6 | Solubility-driven optimization of (pyridin-3-yl) benzoxazinyl-oxazolidinones leading to a promising antibacterial agent. |
| AID285087 | Antimicrobial activity against viridans group Streptococcus constellatus at 1 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID1649281 | Antibacterial activity against methicillin-resistant Staphylococcus aureus SR3637 assessed as inhibition of bacterial growth incubated for 20 hrs by microdilution broth method | |||
| AID535030 | Antimicrobial activity against vancomycin intermediate Staphylococcus aureus NRS-73 expressing SCCmec type 4d element by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | In vitro activity of ceftaroline against community-associated methicillin-resistant, vancomycin-intermediate, vancomycin-resistant, and daptomycin-nonsusceptible Staphylococcus aureus isolates. |
| AID1699553 | Induction of cell membrane permeabilization in methicillin resistant Staphylococcus aureus ATCC 700699 measured at 5 mins interval for 2 hrs by propidium iodide staining based fluorescence assay | 2020 | Journal of medicinal chemistry, 11-12, Volume: 63, Issue:21 | Nature-Inspired (di)Azine-Bridged Bisindole Alkaloids with Potent Antibacterial |
| AID1647981 | Antibacterial activity against Klebsiella pneumoniae by resazurin dye based microdilution method | 2020 | Journal of natural products, 02-28, Volume: 83, Issue:2 | The Isolation of Pyrroloformamide Congeners and Characterization of Their Biosynthetic Gene Cluster. |
| AID1271209 | Metabolic stability in human plasma by LC-MS/MS analysis | 2015 | ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11 | Design, Synthesis, and Identification of Silicon Incorporated Oxazolidinone Antibiotics with Improved Brain Exposure. |
| AID590150 | Antibacterial activity against methicillin-resistant Staphylococcus aureus Smith infected iv dosed ICR mouse assessed as protection against mouse mortality administered 1 hr after infection measured up to 7 days | 2011 | European journal of medicinal chemistry, Apr, Volume: 46, Issue:4 | Discovery of torezolid as a novel 5-hydroxymethyl-oxazolidinone antibacterial agent. |
| AID1647979 | Antibacterial activity against Methicillin resistant Staphylococcus aureus by resazurin dye based microdilution method | 2020 | Journal of natural products, 02-28, Volume: 83, Issue:2 | The Isolation of Pyrroloformamide Congeners and Characterization of Their Biosynthetic Gene Cluster. |
| AID542905 | Antimicrobial activity against Bacillus anthracis infected in in vitro hollow fiber PK/PD model assessed as bacterial regrowth at 400 mg administered once every 24 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID1898396 | Antibacterial activity against methicillin-resistant Staphylococcus aureus BAA-1707 assessed as bacterial growth inhibition incubated for 16 hrs by broth microdilution susceptibility test | 2021 | Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11 | A Modular Synthetic Route Involving |
| AID559801 | Antimicrobial activity against vancomycin-susceptible Staphylococcus aureus assessed as growth inhibition at 2 times MIC | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID562633 | Antimicrobial activity against Streptococcus pneumoniae assessed as susceptible isolates by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | In vitro activities of three new dihydrofolate reductase inhibitors against clinical isolates of gram-positive bacteria. |
| AID753125 | Antibacterial activity against 16-membered ring macrolide- lincosamide-streptogramin B-resistant Staphylococcus MTCC 2940 assessed as growth inhibition after 24 hrs by agar dilution method | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | Anti-tubercular agents. Part 7: a new class of diarylpyrrole-oxazolidinone conjugates as antimycobacterial agents. |
| AID285019 | Antimicrobial activity against Listeria monocytogenes at <= 0.06 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID285134 | Antimicrobial activity against viridans group Streptococcus sanguinis at 1 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID520024 | Antimicrobial activity against Enterococcus faecalis A5962 | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID1594374 | Antibacterial activity against Pseudomonas aeruginosa ATCC 15442 after 18 to 24 hrs in presence of colistin by broth microdilution assay | 2019 | Bioorganic & medicinal chemistry, 05-01, Volume: 27, Issue:9 | Second-generation aryl isonitrile compounds targeting multidrug-resistant Staphylococcus aureus. |
| AID609060 | Antibacterial activity against Pseudomonas aeruginosa ATCC 25668 at 1 mg/ml after 24 hrs by agar-well diffusion technique | 2011 | European journal of medicinal chemistry, Jul, Volume: 46, Issue:7 | A regioselective synthesis of some new pyrazol-1'-ylpyrazolo[1,5-a]pyrimidines in aqueous medium and their evaluation as antimicrobial agents. |
| AID1414191 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 after 24 hrs by broth microdilution based CLSI method | 2018 | European journal of medicinal chemistry, Nov-05, Volume: 159 | Design, synthesis and structure-based optimization of novel isoxazole-containing benzamide derivatives as FtsZ modulators. |
| AID560368 | Antimicrobial activity against vancomycin-susceptible Enterococcus faecalis ATCC 29212 by broth dilution method in presence of 4% HSA | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Impact of human serum albumin on oritavancin in vitro activity against enterococci. |
| AID245105 | In vitro minimum inhibitory concentration of compound against Staphylococcus aureus ATCC 49951 (Smith) | 2005 | Bioorganic & medicinal chemistry letters, Jan-17, Volume: 15, Issue:2 | Effects of positional and geometrical isomerism on the biological activity of some novel oxazolidinones. |
| AID573151 | Antibacterial activity against vancomycin-susceptible Enterococcus faecalis assessed as resistant isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID1409849 | Antibacterial activity against vancomycin-intermediate Staphylococcus aureus Mu50 infected in BALB/c mouse assessed as reduction of bacterial burden in liver at 0.4 mg, ip bid administered at 12 hrs prior to bacterial infection dosed at 12 intervals for 4 | 2018 | ACS medicinal chemistry letters, Mar-08, Volume: 9, Issue:3 | Novel Staphyloxanthin Inhibitors with Improved Potency against Multidrug Resistant |
| AID1553381 | Inhibition of CYP2C9 (unknown origin) | 2019 | Bioorganic & medicinal chemistry letters, 09-15, Volume: 29, Issue:18 | Incorporation of a chiral gem-disubstituted nitrogen heterocycle yields an oxazolidinone antibiotic with reduced mitochondrial toxicity. |
| AID565485 | Bactericidal activity against methicillin-susceptible Staphylococcus aureus after 24 hrs by M26-A method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro bactericidal activity of iclaprim in human plasma. |
| AID541073 | Tmax in cage fluid of Albino guiena pig at 50 mg/kg, ip | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Linezolid alone or combined with rifampin against methicillin-resistant Staphylococcus aureus in experimental foreign-body infection. |
| AID1596552 | Antibacterial activity against vancomycin resistant Staphylococcus aureus VRS12 assessed as reduction in bacterial cell growth incubated for 18 to 20 hrs by broth microdilution method | 2019 | European journal of medicinal chemistry, Aug-01, Volume: 175 | Lipophilic efficient phenylthiazoles with potent undecaprenyl pyrophosphatase inhibitory activity. |
| AID428281 | Antituberculosis activity against linezolid-resistant Mycobacterium tuberculosis without mutation in 23S rRNA | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | In vitro-selected linezolid-resistant Mycobacterium tuberculosis mutants. |
| AID581664 | Antibacterial activity against Staphylococcus aureus SCV isolated from cystic fibrosis patient infected in human THP-1 cells assessed as log reduction of intracellular CFU level per mg of protein after 24 hrs | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Intracellular activity of antibiotics in a model of human THP-1 macrophages infected by a Staphylococcus aureus small-colony variant strain isolated from a cystic fibrosis patient: pharmacodynamic evaluation and comparison with isogenic normal-phenotype a |
| AID522919 | Antibacterial activity against community-acquired methicillin-resistant panton-valentine leukocidin-positive Staphylococcus aureus isolate 1469 after 24 hrs by modified broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Antistaphylococcal activity of ACHN-490 tested alone and in combination with other agents by time-kill assay. |
| AID582993 | Antimicrobial activity against Enterococcus faecium BM-0661 transconjugant by Etest | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | vanM, a new glycopeptide resistance gene cluster found in Enterococcus faecium. |
| AID756091 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae assessed as growth inhibition after 16 hrs by agar dilution method | 2013 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 23, Issue:13 | Synthesis and biological evaluation of novel benzoxazinyl-oxazolidinones as potential antibacterial agents. |
| AID326514 | Cmin in Enterococcus faecalis infected Wistar rat at single administration of 600 mg, po | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Single-dose oral amoxicillin or linezolid for prophylaxis of experimental endocarditis due to vancomycin-susceptible and vancomycin-resistant Enterococcus faecalis. |
| AID581658 | Cmax in human plasma | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Intracellular activity of antibiotics in a model of human THP-1 macrophages infected by a Staphylococcus aureus small-colony variant strain isolated from a cystic fibrosis patient: pharmacodynamic evaluation and comparison with isogenic normal-phenotype a |
| AID40326 | Minimum inhibitory concentration against Bacillus cereus MTCC 430 | 2004 | Bioorganic & medicinal chemistry letters, Jun-21, Volume: 14, Issue:12 | Oxazolidinone: search for highly potent antibacterial. |
| AID1474260 | Ratio of MBC50 to MIC50 for Enterococcus faecium clinical isolates | 2017 | Journal of medicinal chemistry, 03-23, Volume: 60, Issue:6 | Phenylthiazole Antibacterial Agents Targeting Cell Wall Synthesis Exhibit Potent Activity in Vitro and in Vivo against Vancomycin-Resistant Enterococci. |
| AID477376 | Antibacterial activity against Streptococcus pyogenes after 24 hrs | 2009 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13 | Synthesis and antibacterial evaluation of isoxazolinyl oxazolidinones: Search for potent antibacterial. |
| AID1432971 | Cytotoxicity against African green monkey Vero cells assessed as growth inhibition after 48 hrs by MTT assay | |||
| AID1594369 | Antibacterial activity against Klebsiella pneumoniae ATCC BAA-1705 after 18 to 24 hrs by broth microdilution assay | 2019 | Bioorganic & medicinal chemistry, 05-01, Volume: 27, Issue:9 | Second-generation aryl isonitrile compounds targeting multidrug-resistant Staphylococcus aureus. |
| AID498901 | fCmax in immunocompetent SKH1 mouse plasma at 50 mg/kg, po | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vivo activity of ceftobiprole in murine skin infections due to Staphylococcus aureus and Pseudomonas aeruginosa. |
| AID429429 | Antibacterial activity against Haemophilus influenzae isolate 285 by agar dilution method | 2009 | European journal of medicinal chemistry, Aug, Volume: 44, Issue:8 | Synthesis and antibacterial activity of novel 5-(4-methyl-1H-1,2,3-triazole) methyl oxazolidinones. |
| AID1888846 | Antibacterial activity against Staphylococcus aureus 1199B measured after 24 hrs by Muller Hinton broth based MTT assay | 2022 | Bioorganic & medicinal chemistry, 01-15, Volume: 54 | Potentiating the intracellular killing of Staphylococcus aureus by dihydroquinazoline analogues as NorA efflux pump inhibitor. |
| AID562590 | Antimicrobial activity against vancomycin-susceptible Enterococcus faecium clinical isolates assessed as resistant isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID583706 | Antibacterial activity against clinical-derived Staphylococcus aureus isolate harboring ribosomal protein L3 deltaSer145/His146Tyr mutant by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Elevated linezolid resistance in clinical cfr-positive Staphylococcus aureus isolates is associated with co-occurring mutations in ribosomal protein L3. |
| AID573874 | Antibacterial activity against penicillin-susceptible Streptococcus pneumoniae ATCC 6301 infected in iv dosed Swiss Webster mouse administered at 1 to 3 hrs post infection measured after 3 days | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | In vivo activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. |
| AID585170 | Antibacterial activity against Mycobacterium smegmatis harboring 23S rRNA U2504G mutant after 24 generation times | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Mutations in 23S rRNA at the peptidyl transferase center and their relationship to linezolid binding and cross-resistance. |
| AID10752 | Clearance (Cl) of compound (10 mg/kg) after iv administration was determined in Sprague-Dawley rat | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | The effect of remote chirality on the antibacterial activity of indolinyl, tetrahydroquinolyl and dihydrobenzoxazinyl oxazolidinones. |
| AID558720 | Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus 1287 measured on day 45 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID1079941 | Liver damage due to vascular disease: peliosis hepatitis, hepatic veno-occlusive disease, Budd-Chiari syndrome. Value is number of references indexed. [column 'VASC' in source] | |||
| AID1168008 | Antibacterial activity against vancomycin-resistant Enterococcus faecium clinical isolate 15/213 after overnight incubation by two-fold serial dilution method | 2014 | Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21 | Synthesis and biological evaluation of novel peptide BF2 as an antibacterial agent against clinical isolates of vancomycin-resistant enterococci. |
| AID1493802 | Antibacterial activity against Staphylococcus aureus NRS119 clinical isolate after 20 hrs by broth microdilution method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Biphenylthiazole antibiotics with an oxadiazole linker: An approach to improve physicochemical properties and oral bioavailability. |
| AID565005 | Antimicrobial activity against methicillin-susceptible coagulase-negative Staphylococcus epidermidis assessed as susceptible isolates after 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID572271 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus NB01021 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vivo characterization of the peptide deformylase inhibitor LBM415 in murine infection models. |
| AID1167734 | Antimicrobial activity against methicillin-resistant and quinolone-resistant Staphylococcus aureus by broth microdilution method | 2014 | Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21 | Novel DNA gyrase inhibiting spiropyrimidinetriones with a benzisoxazole scaffold: SAR and in vivo characterization. |
| AID1434677 | Anti-bacterial activity against methicillin-susceptible Staphylococcus aureus CCARM 0205 by 2-fold microtiter broth dilution method | 2017 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 27, Issue:3 | Cadiolides J-M, antibacterial polyphenyl butenolides from the Korean tunicate Pseudodistoma antinboja. |
| AID311485 | Antimicrobial activity against Escherichia coli ATCC 25922 after 14 to 16 hrs by serial micro-broth dilution method | 2007 | Journal of natural products, Sep, Volume: 70, Issue:9 | Lipoxazolidinones A, B, and C: antibacterial 4-oxazolidinones from a marine actinomycete isolated from a Guam marine sediment. |
| AID559550 | Antimicrobial activity against compound-resistant Coxiella burnetii isolate CP4 obtained from patient with acute Q fever infected in african green monkey Vero cells after 24 hrs by shell vial assay | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Bacteriostatic and bactericidal activities of tigecycline against Coxiella burnetii and comparison with those of six other antibiotics. |
| AID687495 | AUC (0 to infinity) in rat at 10 mg/kg, iv | 2012 | Bioorganic & medicinal chemistry, Oct-15, Volume: 20, Issue:20 | Antitubercular nitrofuran isoxazolines with improved pharmacokinetic properties. |
| AID1076829 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 assessed as growth inhibition after 18 hrs by broth microdilution method | 2014 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 24, Issue:6 | Discovery of novel bis-oxazolidinone compounds as potential potent and selective antitubercular agents. |
| AID410225 | Antibacterial activity against Moraxella catarrhalis by broth micro dilution method | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24 | A facile synthesis, antibacterial, and antitubercular studies of some piperidin-4-one and tetrahydropyridine derivatives. |
| AID581667 | Antibacterial activity against Staphylococcus aureus SCV isolated from cystic fibrosis patient infected in human THP-1 cells assessed as log reduction of intracellular CFU level after 24 hrs in presence of thymidine | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Intracellular activity of antibiotics in a model of human THP-1 macrophages infected by a Staphylococcus aureus small-colony variant strain isolated from a cystic fibrosis patient: pharmacodynamic evaluation and comparison with isogenic normal-phenotype a |
| AID424768 | Antibacterial activity against penicillin-sensitive Streptococcus pneumoniae CL8002 after 20 hrs by twofold serial broth dilution method | 2009 | Journal of natural products, May-22, Volume: 72, Issue:5 | Thiazomycins, thiazolyl peptide antibiotics from Amycolatopsis fastidiosa. |
| AID68247 | In vitro antibacterial activity against vancomycin and ciprofloxacin resistant Enterococcus faecium (Efm CIP) was determined | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | Structure-activity relationship in the oxazolidinone-quinolone hybrid series: influence of the central spacer on the antibacterial activity and the mode of action. |
| AID753116 | Antibacterial activity against Staphylococcus aureus MTCC 96 assessed as growth inhibition at 20 mg/mL after 24 hrs | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | Anti-tubercular agents. Part 7: a new class of diarylpyrrole-oxazolidinone conjugates as antimycobacterial agents. |
| AID1904918 | Antibacterial activity against methicillin-resistant Staphylococcus aureus NRS 385 (USA500) incubated for 18 to 20 hrs by broth microdilution method | 2022 | European journal of medicinal chemistry, Apr-15, Volume: 234 | Exploring the structure-activity relationships of diphenylurea as an antibacterial scaffold active against methicillin- and vancomycin-resistant Staphylococcus aureus. |
| AID283167 | Antimicrobial susceptibility of Staphylococcus lugdunensis IDRL5254 biofilms after 24 hrs assessed as bacterial regrowth | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | In vitro effects of antimicrobial agents on planktonic and biofilm forms of Staphylococcus lugdunensis clinical isolates. |
| AID285109 | Antimicrobial activity against viridans group Streptococcus mutans at 0.5 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID569341 | Antibacterial activity against methicillin-resistant Staphylococcus epidermidis ATCC 12228 by broth micro dilution technique | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 | Design, synthesis and antibacterial activity of 3-methylenepyrrolidine formyl hydroxyamino derivatives as novel peptide deformylase inhibitors. |
| AID576396 | Tmax in two-compartment pharmacokinetic/pharmacodynamic model at 200 mg, bid administered as 0.5 hrs infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID1493812 | Antibacterial activity against Klebsiella pneumoniae BAA-1706 after 20 hrs by broth microdilution method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Biphenylthiazole antibiotics with an oxadiazole linker: An approach to improve physicochemical properties and oral bioavailability. |
| AID1421235 | Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay | 2018 | European journal of medicinal chemistry, Oct-05, Volume: 158 | Synthesis and antibacterial activity evaluation of novel biaryloxazolidinone analogues containing a hydrazone moiety as promising antibacterial agents. |
| AID560577 | Bactericidal activity against vancomycin-resistant Enterococcus faecalis 1058946 expressing vanA gene assessed as change in bacterial count at 16 ug/ml by time-kill assay | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Impact of human serum albumin on oritavancin in vitro activity against enterococci. |
| AID1271219 | AUC (0 to infinity) in BALB/c mouse plasma at 10 mg/kg, po by LC-MS/MS analysis | 2015 | ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11 | Design, Synthesis, and Identification of Silicon Incorporated Oxazolidinone Antibiotics with Improved Brain Exposure. |
| AID1474262 | Ratio of MBC50 to MIC50 for vancomycin-resistant Enterococcus faecalis clinical isolates | 2017 | Journal of medicinal chemistry, 03-23, Volume: 60, Issue:6 | Phenylthiazole Antibacterial Agents Targeting Cell Wall Synthesis Exhibit Potent Activity in Vitro and in Vivo against Vancomycin-Resistant Enterococci. |
| AID734689 | Antibacterial activity against Staphylococcus MLS-16 MTCC 2940 at 20 ug/ml after 24 hrs by disk diffusion method | 2013 | European journal of medicinal chemistry, Apr, Volume: 62 | Synthesis, biological evaluation of new oxazolidino-sulfonamides as potential antimicrobial agents. |
| AID1400026 | Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 72 hrs by MTT assay | 2018 | Bioorganic & medicinal chemistry, 09-15, Volume: 26, Issue:17 | An antimycobacterial pleuromutilin analogue effective against dormant bacilli. |
| AID572270 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus ATCC 13709 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vivo characterization of the peptide deformylase inhibitor LBM415 in murine infection models. |
| AID1400024 | Antibacterial activity against non-replicating Mycobacterium tuberculosis H37Rv harboring pFCA-luxAB preincubated for 10 days under anaerobic condition followed by incubation under ambient gaseous condition for 28 hrs by LORA | 2018 | Bioorganic & medicinal chemistry, 09-15, Volume: 26, Issue:17 | An antimycobacterial pleuromutilin analogue effective against dormant bacilli. |
| AID560506 | Antimicrobial activity against SCCmec type III vancomycin-intermediate Staphylococcus aureus isolate b3k2345 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID519077 | Antimicrobial activity against wild type Staphylococcus aureus 8325-4 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Linezolid and tiamulin cross-resistance in Staphylococcus aureus mediated by point mutations in the peptidyl transferase center. |
| AID1778659 | Bactericidal activity against methicillin-resistant Staphylococcus aureus ATCC 43300 measured after 24 hrs by CLSI protocol based method | 2021 | European journal of medicinal chemistry, Oct-05, Volume: 221 | Design, synthesis and evaluation of novel 9-arylalkyl-10-methylacridinium derivatives as highly potent FtsZ-targeting antibacterial agents. |
| AID208625 | Antibacterial activity against Streptococcus pneumoniae (PEN-R) | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | Iclaprim, a novel diaminopyrimidine with potent activity on trimethoprim sensitive and resistant bacteria. |
| AID533988 | Bacteriostatic activity against linezolid-resistant Staphylococcus aureus SA040L infected in THP1 cells after 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Cellular pharmacodynamics of the novel biaryloxazolidinone radezolid: studies with infected phagocytic and nonphagocytic cells, using Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Legionella pneumophila. |
| AID528699 | Antibacterial activity against vancomycin resistant Enterococcus faecalis VanB clinical isolate assessed as susceptibility level by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID1861527 | Cmax in Beagle dog at 15 mg/kg, iv | 2022 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 71 | WCK 4034: A promising oxazolidinone for treating gram positive infections. |
| AID244920 | Minimal inhibitory concentration against Salmonella typhi (MDR) ICH 098 | 2004 | Bioorganic & medicinal chemistry letters, Sep-20, Volume: 14, Issue:18 | Synthesis and antibacterial activity of some aryloxy/thioaryloxy oxazolidinone derivatives. |
| AID559786 | Antimicrobial activity against heterogeneous vancomycin-susceptible Staphylococcus aureus assessed as resistant isolates by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID370016 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus Smith infected in C3H mouse assessed as mortality at 12.5 mg/kg/day, iv administered within 15 mins of infection measured after 48 hrs by organ burden assay relative to control | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vivo efficacy of a novel oxazolidinone compound in two mouse models of infection. |
| AID1079943 | Malignant tumor, proven histopathologically. Value is number of references indexed. [column 'T.MAL' in source] | |||
| AID542901 | fT>MIC in Bacillus anthracis infected in vitro hollow fiber PK/PD model at simulated dose of 600 mg administered every 12 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID726194 | Antibacterial activity against Streptococcus pyogenes 308A by agar dilution method | 2013 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 23, Issue:5 | Synthesis and antibacterial activities of new piperidine substituted (5R)-[1,2,3]triazolylmethyl and (5R)-[(4-F-[1,2,3]triazolyl)methyl] oxazolidinones. |
| AID576404 | Terminal half-life in two-compartment pharmacokinetic/pharmacodynamic model at 800 mg, bid administered as 0.5 hrs infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID383741 | Half life in Sprague-Dawley rat at 10 mg/kg, iv | 2008 | European journal of medicinal chemistry, Apr, Volume: 43, Issue:4 | Synthesis and in vitro antibacterial activities of novel oxazolidinones. |
| AID285102 | Antimicrobial activity against viridans group Streptococcus mitis at 0.25 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID625280 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cholecystitis | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID285026 | Antimicrobial activity against Micrococcus luteus at 0.12 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID319981 | Antimicrobial activity against Staphylococcus aureus ATCC 29213 | 2008 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 18, Issue:2 | Synthesis, SAR, and antibacterial activity of novel oxazolidinone analogues possessing urea functionality. |
| AID1609301 | Antibacterial activity against methicillin-resistant Staphylococcus aureus NRS384 USA300 after 18 to 20 hrs by broth microdilution assay | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Phenylthiazoles with nitrogenous side chain: An approach to overcome molecular obesity. |
| AID245330 | Antibacterial activity against Penicillin-resistant Streptococcus pneumoniae (PRSP) J-24 was determined | 2004 | Bioorganic & medicinal chemistry letters, Oct-18, Volume: 14, Issue:20 | Synthesis and antibacterial activity of novel 6-fluoro-1-[(1R,2S)-2-fluorocyclopropan-1-yl]-4-oxoquinoline-3-carboxylic acids bearing cyclopropane-fused 2-amino-8-azabicyclo[4.3.0]nonan-8-yl substituents at the C-7 position. |
| AID323831 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus Xen29 infected neutropenic CD1 mouse assessed as mortality at 100 mg/kg, po after 4 days | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Rapid bactericidal activity of daptomycin against methicillin-resistant and methicillin-susceptible Staphylococcus aureus peritonitis in mice as measured with bioluminescent bacteria. |
| AID1852662 | Antibacterial activity against multidrug resistant Klebsiella pneumoniae ATCC43816 assessed as inhibition of bacterial growth incubated for 24 hrs in M9-MOPS medium by twofold serial dilution method | |||
| AID1430400 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 33591 after 24 to 48 hrs by macro-broth dilution method | 2017 | Bioorganic & medicinal chemistry letters, 03-01, Volume: 27, Issue:5 | Methylsulfonyl benzothiazoles (MSBT) derivatives: Search for new potential antimicrobial and anticancer agents. |
| AID1504617 | Antibacterial activity against Staphylococcus aureus ATCC 33591 by microbroth dilution method | 2017 | ACS medicinal chemistry letters, Nov-09, Volume: 8, Issue:11 | Design, Synthesis, and Antibacterial Evaluation of Oxazolidinones with Fused Heterocyclic C-Ring Substructure. |
| AID308926 | Antibacterial activity against Staphylococcus epidermidis ATCC 155 by broth microdilution method | 2007 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 17, Issue:18 | Synthesis and in vitro antibacterial activity of novel methylamino piperidinyl oxazolidinones. |
| AID552834 | Antibacterial activity against multidrug-resistant Enterococcus faecalis | 2011 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1 | The discovery and structure-activity relationships leading to CE-156811, a difluorophenyl cyclopropyl fluoroether: a novel potent antibacterial analog derived from hygromycin A. |
| AID1435928 | Bactericidal activity against mupirocin/rifampicin-resistant Staphylococcus aureus RN4220 NRS107 clinical isolate after 24 hrs | 2017 | European journal of medicinal chemistry, Jan-27, Volume: 126 | Phenylthiazole antibiotics: A metabolism-guided approach to overcome short duration of action. |
| AID308485 | Inhibition of transcription and translation activity in Escherichia coli by luciferase reporter assay | 2007 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 17, Issue:16 | Synthesis and SAR of novel conformationally restricted oxazolidinones possessing gram-positive and fastidious gram-negative antibacterial activity. Part 2: Amino substitutions on heterocyclic D-ring system. |
| AID499117 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus OC 8525 infected immunocompromized SKH1 mouse assessed as lesion volume at 100 mg/kg/day, sc measured after 48 hrs postinfection (Rvb = 1535 mm3) | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vivo activity of ceftobiprole in murine skin infections due to Staphylococcus aureus and Pseudomonas aeruginosa. |
| AID523821 | Antimicrobial activity against oxacillin-resistant coagulase-negative Staphylococcus aureus assessed as inhibition of microbial growth at 2 ug/ml by CLSI method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative activities of TR-700 (torezolid) against staphylococcal blood isolates collected in Spain. |
| AID576667 | Bactericidal activity against 1 hr peripheral compartment culture samples of Enterococcus faecalis Ef1497 in two-compartment pharmacokinetic/pharmacodynamic model assessed as effect on bacterial count at 600 mg, bid administered as 0.5 hr infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID246829 | Efficacy against mice infected with MRSA-33 upon s.c. administration | 2005 | Journal of medicinal chemistry, Aug-11, Volume: 48, Issue:16 | A chiral benzoquinolizine-2-carboxylic acid arginine salt active against vancomycin-resistant Staphylococcus aureus. |
| AID1861533 | Terminal half life in Beagle dog at 15 mg/kg, iv | 2022 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 71 | WCK 4034: A promising oxazolidinone for treating gram positive infections. |
| AID373655 | Antimicrobial activity against vancomycin-resistant Staphylococcus aureus 510 Hershey by agar dilution CLSI method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID1770339 | Antibacterial activity against penicillin-susceptible Bacillus subtilis ATCC 9372 assessed as inhibition of bacterial growth measured after 20 hrs by two-fold microdilution assay | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Modification of 5-methylphenanthridium from benzothiazoles to indoles as potent FtsZ inhibitors: Broadening the antibacterial spectrum toward vancomycin-resistant enterococci. |
| AID541062 | AUC (0 to 24 hrs) in cage fluid of Albino guiena pig at 50 mg/kg, ip | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Linezolid alone or combined with rifampin against methicillin-resistant Staphylococcus aureus in experimental foreign-body infection. |
| AID608939 | Antibacterial activity against Pseudomonas aeruginosa ATCC 25668 after 24 hrs by broth microdilution method | 2011 | European journal of medicinal chemistry, Jul, Volume: 46, Issue:7 | A regioselective synthesis of some new pyrazol-1'-ylpyrazolo[1,5-a]pyrimidines in aqueous medium and their evaluation as antimicrobial agents. |
| AID1578411 | Antimicrobial activity against methicillin-sensitive Staphylococcus aureus NRS 107 by broth liquid microdilution method | 2020 | European journal of medicinal chemistry, Jan-01, Volume: 185 | Modifying the lipophilic part of phenylthiazole antibiotics to control their drug-likeness. |
| AID245964 | Cytotoxic concentration against Huh7 cells at 48 hours in MTT assay; NT = not tested | 2004 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 14, Issue:22 | Aryl urea analogs with broad-spectrum antibacterial activity. |
| AID285076 | Antimicrobial activity against viridans group Streptococcus anginosus at 2 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID207213 | In vitro minimum inhibitory concentration against coagulase negative Staphylococcus aureus methicillin resistant (CNSMR) | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | New classes of antibacterial oxazolidinones with C-5, methylene O-linked heterocyclic side chains. |
| AID581659 | Fraction unbound in human plasma | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Intracellular activity of antibiotics in a model of human THP-1 macrophages infected by a Staphylococcus aureus small-colony variant strain isolated from a cystic fibrosis patient: pharmacodynamic evaluation and comparison with isogenic normal-phenotype a |
| AID1539455 | Antibacterial activity against Listeria monocytogenes ATCC 19111 after 18 to 20 hrs in aerobic condition by CLSI-based broth microdilution assay | |||
| AID374000 | Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus 555 Hershey after 50 passages with Linezolid measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID285025 | Antimicrobial activity against Micrococcus luteus at <= 0.06 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID575077 | Antimicrobial activity against Streptococcus pneumoniae serotype 3 assessed as percent susceptible isolates by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID209934 | Inhibitory activity against Streptococcus pyogenes | 1996 | Journal of medicinal chemistry, Sep-27, Volume: 39, Issue:20 | New directions in antibacterial research. |
| AID263967 | Antibacterial activity against beta lactamase negative Haemophilus influenzae DRCC 433 | 2006 | Bioorganic & medicinal chemistry letters, May-01, Volume: 16, Issue:9 | Synthesis and antibacterial activity of novel oxazolidinones bearing N-hydroxyacetamidine substituent. |
| AID1873901 | Antibacterial activity against Staphylococcus aureus ATCC 29213 at pH 8.6 incubated for 16 to 20 hrs in presence of 50% foetal bovine serum by broth microdilution method | 2022 | European journal of medicinal chemistry, Aug-05, Volume: 238 | Design, synthesis and activity against drug-resistant bacteria evaluation of C-20, C-23 modified 5-O-mycaminosyltylonolide derivatives. |
| AID1853461 | Bactericidal activity against vancomycin-resistant Enterococcus faecalis ATCC 51575 assessed as reduction in colony forming unit incubated for 20 hrs | 2021 | RSC medicinal chemistry, Nov-17, Volume: 12, Issue:11 | SF |
| AID577137 | Total clearance in two-compartment pharmacokinetic/pharmacodynamic model at 600 mg, bid administered as 0.5 hr infusion over 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID1167729 | Fraction unbound in human plasma at 10 uM after 16 hrs by LC-MS/MS analysis | 2014 | Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21 | Novel DNA gyrase inhibiting spiropyrimidinetriones with a benzisoxazole scaffold: SAR and in vivo characterization. |
| AID206786 | Inhibitory activity against MRSA | 1996 | Journal of medicinal chemistry, Sep-27, Volume: 39, Issue:20 | New directions in antibacterial research. |
| AID125126 | In vivo antibacterial activity against Staphylococcus aureus after intramuscular administration (10 mg/kg) in mice using (MTT) mouse thigh test | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | New classes of antibacterial oxazolidinones with C-5, methylene O-linked heterocyclic side chains. |
| AID1395703 | Bactericidal activity against methicillin-sensitive Staphylococcus aureus ATCC 6538 incubated fo 18 hrs followed by re-plating on tryptic soy agar plates at 37 degC for 18 hrs by broth microdilution assay | 2018 | European journal of medicinal chemistry, May-10, Volume: 151 | Phenylthiazoles with tert-Butyl side chain: Metabolically stable with anti-biofilm activity. |
| AID524719 | Antibacterial activity against linezolid-resistant Staphylococcus aureus 01A1221 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro antibacterial activity of CE-156811, a novel analog derived from hygromycin A. |
| AID630559 | Antibacterial activity against linezolid-resistant Staphylococcus aureus after 16 hrs by agar dilution method | 2011 | Journal of medicinal chemistry, Nov-10, Volume: 54, Issue:21 | Design, synthesis, and structure-activity relationship studies of highly potent novel benzoxazinyl-oxazolidinone antibacterial agents. |
| AID1056359 | Antibacterial activity against Enterococcus faecium SR7940 clinical isolate assessed as parasite growth inhibition by CLSI broth microdilution method | 2013 | ACS medicinal chemistry letters, Nov-14, Volume: 4, Issue:11 | Potent oxazolidinone antibacterials with heteroaromatic C-ring substructure. |
| AID1677799 | Bactericidal activity against methicillin-resistant Staphylococcus aureus ATCC43300 assessed as reduction in number of colony forming units incubated for 24 hrs followed by re-plating and reincubation on tryptic soy agar plate for 24 hrs | 2020 | Bioorganic & medicinal chemistry, 11-01, Volume: 28, Issue:21 | Design, synthesis of novel 4,5-dihydroisoxazole-containing benzamide derivatives as highly potent FtsZ inhibitors capable of killing a variety of MDR Staphylococcus aureus. |
| AID585168 | Antibacterial activity against Mycobacterium smegmatis harboring 23S rRNA G2032A mutant after 24 generation times | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Mutations in 23S rRNA at the peptidyl transferase center and their relationship to linezolid binding and cross-resistance. |
| AID1687313 | Synergistic antibacterial activity against Klebsiella pneumoniae ATCC 1706 in presence of 0.25 times MIC of colistin incubated for 18 to 20 hrs by broth microdilution method | 2020 | European journal of medicinal chemistry, Jan-15, Volume: 186 | Development of benzimidazole-based derivatives as antimicrobial agents and their synergistic effect with colistin against gram-negative bacteria. |
| AID244870 | Minimum inhibitory concentration against Pseudomonas aeruginosa ATCC 25416 | 2004 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 14, Issue:22 | Aryl urea analogs with broad-spectrum antibacterial activity. |
| AID205899 | Minimum inhibitory concentration measured against Staphylococcus epidermidis | 2002 | Bioorganic & medicinal chemistry letters, Aug-19, Volume: 12, Issue:16 | The synthesis and biological evaluation of a novel series of antimicrobials of the oxazolidinone class. |
| AID1205588 | Antibacterial activity against Haemophilus influenzae acrB by broth microdilution method | 2015 | Journal of medicinal chemistry, Apr-09, Volume: 58, Issue:7 | X-ray crystal structures of Escherichia coli RNA polymerase with switch region binding inhibitors enable rational design of squaramides with an improved fraction unbound to human plasma protein. |
| AID1649282 | Antibacterial activity against Vancomycin-resistant Staphylococcus aureus HIP11714 assessed as inhibition of bacterial growth incubated for 20 hrs by microdilution broth method | |||
| AID558475 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus 540 measured on day 5 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID352922 | Antibacterial activity against Coagulase negative Staphylococcus after 18 to 20 hrs by agar dilution method | 2009 | Bioorganic & medicinal chemistry letters, May-01, Volume: 19, Issue:9 | Synthesis and antibacterial activities of novel oxazolidinones having spiro[2,4]heptane moieties. |
| AID206056 | Inhibitory activity against methicillin-sensitive Staphylococcus epidermidis (MSSE) | 1996 | Journal of medicinal chemistry, Sep-27, Volume: 39, Issue:20 | New directions in antibacterial research. |
| AID1680011 | Antibiofilm activity against Staphylococcus aureus ATCC 29213 assessed as inhibition of biofilm formation incubated for 24 hrs by crystal violet staining assay | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Synthesis and antibacterial bioactivities of cationic deacetyl linezolid amphiphiles. |
| AID1395705 | Bactericidal activity against methicillin-resistant Staphylococcus aureus NRS119 incubated fo 18 hrs followed by re-plating on tryptic soy agar plates at 37 degC for 18 hrs by broth microdilution assay | 2018 | European journal of medicinal chemistry, May-10, Volume: 151 | Phenylthiazoles with tert-Butyl side chain: Metabolically stable with anti-biofilm activity. |
| AID1421222 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus by broth liquid microdilution method | 2018 | European journal of medicinal chemistry, Oct-05, Volume: 158 | Synthesis and antibacterial activity evaluation of novel biaryloxazolidinone analogues containing a hydrazone moiety as promising antibacterial agents. |
| AID559771 | Antimicrobial activity against SCCmec type II vancomycin-intermediate Staphylococcus aureus isolate 4sy39 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID285317 | Antimicrobial activity against Rhodococcus spp. by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Daptomycin susceptibility of unusual gram-positive bacteria: comparison of results obtained by the Etest and the broth microdilution method. |
| AID519080 | Antimicrobial activity wild type Escherichia coli SQ110 by agar dilution method in presence of 16 ug/ml polymyxin B nonapeptide | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Linezolid and tiamulin cross-resistance in Staphylococcus aureus mediated by point mutations in the peptidyl transferase center. |
| AID523820 | Antimicrobial activity against oxacillin-resistant coagulase-negative Staphylococcus aureus assessed as inhibition of microbial growth at 1 ug/ml by CLSI method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative activities of TR-700 (torezolid) against staphylococcal blood isolates collected in Spain. |
| AID245010 | In vitro minimum inhibitory concentration against Salmonella abony (NCTC 6017) | 2005 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 15, Issue:12 | Synthesis and antibacterial activity of novel (un)substituted benzotriazolyl oxazolidinone derivatives. |
| AID319163 | Total clearance in human | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7 | Linezolid (ZYVOX), the first member of a completely new class of antibacterial agents for treatment of serious gram-positive infections. |
| AID559368 | Antimicrobial activity against compound-intermediate susceptible Coxiella burnetii isolate CP2 obtained from patient with acute Q fever infected in african green monkey Vero cells after 24 hrs by shell vial assay | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Bacteriostatic and bactericidal activities of tigecycline against Coxiella burnetii and comparison with those of six other antibiotics. |
| AID562235 | Antibacterial activity against methicillin-resistant Staphylococcus aureus OC2878 assessed as inhibition of bacterial regrowth at 16 times MIC after 8 hrs by dynamic time kill study | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Pharmacokinetic-pharmacodynamic modeling of the in vitro activities of oxazolidinone antimicrobial agents against methicillin-resistant Staphylococcus aureus. |
| AID533974 | Antimicrobial activity against linezolid-susceptible Staphylococcus aureus ATCC 25923 infected in THP1 cells after 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Cellular pharmacodynamics of the novel biaryloxazolidinone radezolid: studies with infected phagocytic and nonphagocytic cells, using Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Legionella pneumophila. |
| AID1243933 | Antimicrobial activity against vancomycin-resistant Staphylococcus aureus VRS2 assessed as reduction in bacterial growth incubated for 18 to 20 hrs at 37 degC by broth microdilution method | 2015 | European journal of medicinal chemistry, Aug-28, Volume: 101 | Discovery and characterization of aryl isonitriles as a new class of compounds versus methicillin- and vancomycin-resistant Staphylococcus aureus. |
| AID763985 | Antibacterial activity against methicillin-resistant coagulase-negative Staphylococcus after 18 hrs by NCCLS agar dilution method | 2013 | European journal of medicinal chemistry, Aug, Volume: 66 | Synthesis and antibacterial activities of N-substituted-glycinyl 1H-1,2,3-triazolyl oxazolidinones. |
| AID1056344 | Tmax in ICR mouse at 67.7 mg/kg, po by LC-MS/MS analysis | 2013 | ACS medicinal chemistry letters, Nov-14, Volume: 4, Issue:11 | Potent oxazolidinone antibacterials with heteroaromatic C-ring substructure. |
| AID284980 | Antimicrobial activity against Enterococcus avium at <= 0.06 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID50998 | In vitro antibacterial activity against Clostridium perfringens strain ATCC 13124 | 1996 | Journal of medicinal chemistry, Feb-02, Volume: 39, Issue:3 | Synthesis and antibacterial activity of U-100592 and U-100766, two oxazolidinone antibacterial agents for the potential treatment of multidrug-resistant gram-positive bacterial infections. |
| AID245331 | Antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) 870307 was determined | 2004 | Bioorganic & medicinal chemistry letters, Oct-18, Volume: 14, Issue:20 | Synthesis and antibacterial activity of novel 6-fluoro-1-[(1R,2S)-2-fluorocyclopropan-1-yl]-4-oxoquinoline-3-carboxylic acids bearing cyclopropane-fused 2-amino-8-azabicyclo[4.3.0]nonan-8-yl substituents at the C-7 position. |
| AID522908 | Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate 2003 after 24 hrs by modified broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Antistaphylococcal activity of ACHN-490 tested alone and in combination with other agents by time-kill assay. |
| AID285550 | Tmax in mouse at 50 mg/kg, sc | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | In vitro and in vivo antibacterial activities of heteroaryl isothiazolones against resistant gram-positive pathogens. |
| AID319164 | Renal clearance in human | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7 | Linezolid (ZYVOX), the first member of a completely new class of antibacterial agents for treatment of serious gram-positive infections. |
| AID534249 | Antimicrobial activity against linezolid-susceptible Staphylococcus aureus SA238 infected in THP-1 cells at pH 5.5 after 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Cellular pharmacodynamics of the novel biaryloxazolidinone radezolid: studies with infected phagocytic and nonphagocytic cells, using Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Legionella pneumophila. |
| AID560369 | Antimicrobial activity against vancomycin-resistant Enterococcus faecium ATCC 51559 by broth dilution method in presence of 4% HAS | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Impact of human serum albumin on oritavancin in vitro activity against enterococci. |
| AID28208 | Tmax value in Male Sprague-Dawley Rat at dose 10 (mg/kg iv) [tmax (h)]; ND denotes not reported | 2003 | Journal of medicinal chemistry, Jan-16, Volume: 46, Issue:2 | Identification of phenylisoxazolines as novel and viable antibacterial agents active against Gram-positive pathogens. |
| AID576413 | Total clearance in two-compartment pharmacokinetic/pharmacodynamic model at 800 mg, bid administered as 0.5 hrs infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID574073 | Half life in CF-1 mouse at 10 mg/kg, sc | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | In vivo activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. |
| AID576403 | Terminal half-life in two-compartment pharmacokinetic/pharmacodynamic model at 600 mg, bid administered as 0.5 hrs infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID577114 | ABBC (0 to 24 hrs) in Enterococcus faecalis Ef1497 in two-compartment pharmacokinetic/pharmacodynamic model at 600 mg, bid administered as 0.5 hr infusion for 2 days | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID751392 | Inhibition of MAO-A (unknown origin) by luciferase reporter gene assay | 2013 | Bioorganic & medicinal chemistry, Feb-01, Volume: 21, Issue:3 | Recent development of potent analogues of oxazolidinone antibacterial agents. |
| AID1117391 | Antimicrobial activity against Pseudomonas aeruginosa K799/61 assessed as partially clear inhibition zone at 37 degC for 24 hrs by agar diffusion method | 2010 | MedChemComm, Aug-01, Volume: 1, Issue:2 | Syntheses and biological evaluation of new cephalosporin-oxazolidinone conjugates. |
| AID1327107 | Antibacterial activity against Escherichia coli NCIM 2688 at 3 ug/ml measured after 8 hrs by spectrophotometric method | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Design, synthesis and biological evaluation of novel azaspiro analogs of linezolid as antibacterial and antitubercular agents. |
| AID1519037 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus assessed as complete reduction in bacterial cell growth by CLSI protocol based broth liquid microdilution method | 2020 | European journal of medicinal chemistry, Jan-01, Volume: 185 | Optimization of biaryloxazolidinone as promising antibacterial agents against antibiotic-susceptible and antibiotic-resistant gram-positive bacteria. |
| AID535037 | Antimicrobial activity against vancomycin intermediate Staphylococcus aureus NRS-404 expressing SCCmec type 2 element by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | In vitro activity of ceftaroline against community-associated methicillin-resistant, vancomycin-intermediate, vancomycin-resistant, and daptomycin-nonsusceptible Staphylococcus aureus isolates. |
| AID581039 | Induction of bacterial membrane damage in Staphylococcus epidermidis ATCC 23760 at 4 ug/mL by BacLight assay | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Mode of action of Ranbezolid against staphylococci and structural modeling studies of its interaction with ribosomes. |
| AID244977 | Antibacterial activity against Klebsiella pneumoniae type II was determined | 2004 | Bioorganic & medicinal chemistry letters, Oct-18, Volume: 14, Issue:20 | Synthesis and antibacterial activity of novel 6-fluoro-1-[(1R,2S)-2-fluorocyclopropan-1-yl]-4-oxoquinoline-3-carboxylic acids bearing cyclopropane-fused 2-amino-8-azabicyclo[4.3.0]nonan-8-yl substituents at the C-7 position. |
| AID541046 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 infected in Albino guiena pig assessed as decrease in planktonic bacterial counts in cage fluid at 75 mg/kg measured on day 4 postinfection | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Linezolid alone or combined with rifampin against methicillin-resistant Staphylococcus aureus in experimental foreign-body infection. |
| AID1193402 | Antimicrobial activity against Francisella tularensis BEI/ATCC UTAH 112 measured after overnight incubation | 2015 | Bioorganic & medicinal chemistry, Apr-01, Volume: 23, Issue:7 | Identification of Bacillus anthracis PurE inhibitors with antimicrobial activity. |
| AID449615 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus by agar dilution method | 2009 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 19, Issue:18 | Water-soluble phosphate prodrugs of pleuromutilin analogues with potent in vivo antibacterial activity against Gram-positive pathogens. |
| AID576646 | Bactericidal activity against 24 hrs peripheral compartment culture samples of Staphylococcus aureus RN4220 MutS2 in two-compartment pharmacokinetic/pharmacodynamic model assessed as effect on bacterial count at 600 mg, bid administered as 0.5 hr infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID561726 | Antibacterial activity against Enterococcus faecalis assessed as resistant isolates by CLSI broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Potency and bactericidal activity of iclaprim against recent clinical gram-positive isolates. |
| AID1374176 | Antibacterial activity against Enterococcus faecalis ATCC 35667 incubated at 37 degC for 20 hrs by agar dilution method | 2018 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4 | Design, synthesis and antibacterial evaluation of honokiol derivatives. |
| AID326292 | Antibacterial activity against methicillin-resistant Staphylococcus aureus 4930 at 4 hrs daily exposure for 5 days by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Comparative activities of daptomycin, linezolid, and tigecycline against catheter-related methicillin-resistant Staphylococcus bacteremic isolates embedded in biofilm. |
| AID326506 | Cmax in Enterococcus faecalis infected Wistar rat at 600 mg, po four consecutive administration every 12 hrs | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Single-dose oral amoxicillin or linezolid for prophylaxis of experimental endocarditis due to vancomycin-susceptible and vancomycin-resistant Enterococcus faecalis. |
| AID1194833 | Antibacterial activity against methicillin-resistant Staphylococcus aureus incubated for 16 hrs by agar dilution method | 2015 | Bioorganic & medicinal chemistry letters, , Volume: 25, Issue:10 | Synthesis and structure-activity relationship studies of novel [6,6,5] tricyclic oxazolidinone derivatives as potential antibacterial agents. |
| AID1539444 | Antibacterial activity against Methicillin-sensitive Staphylococcus aureus NRS107 clinical isolates after 18 to 20 hrs in aerobic condition by CLSI protocol based broth microdilution assay | |||
| AID373666 | Antimicrobial activity against panton-valentine leukocidin-positive community-acquired methicillin-resistant Staphylococcus aureus 490 after 22 passages by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID392204 | Antibacterial activity against Streptococcus pyogenes C-203 by micro broth method | 2009 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 19, Issue:2 | Synthesis and structure-activity studies of novel homomorpholine oxazolidinone antibacterial agents. |
| AID396030 | Antibacterial activity against drug-resistant AcrAB-TolC efflux pump deficient Enterobacter cloacae EcdeltaacrA isolate expressing pAP2 plasmid containing Enterobacter cloacae acrA gene by Etest | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Cloning, nucleotide sequencing, and analysis of the AcrAB-TolC efflux pump of Enterobacter cloacae and determination of its involvement in antibiotic resistance in a clinical isolate. |
| AID245413 | Minimum inhibitory concentration against ampicillin-reisitant Haemophilus influenzae UC30063; Range is 8-16 ug/mL | 2005 | Journal of medicinal chemistry, Jul-28, Volume: 48, Issue:15 | Conformational constraint in oxazolidinone antibacterials. Synthesis and structure-activity studies of (azabicyclo[3.1.0]hexylphenyl)oxazolidinones. |
| AID1151772 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus ATCC 29213 in mouse thigh infection model assessed as reduction of log10 CFU per thigh at 10 mg/kg, po | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID533019 | Antibacterial activity against vancomycin-susceptible Staphylococcus aureus N315-LR5-P1-2 assessed as inhibition of bacterial growth in Mueller-Hinton broth medium | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Improved antimicrobial activity of linezolid against vancomycin-intermediate Staphylococcus aureus. |
| AID1514453 | Antitubercular activity against moxifloxacin-resistant Mycobacterium tuberculosis after 7 days by resazurin dye based colorimetric assay | 2019 | Bioorganic & medicinal chemistry letters, 01-01, Volume: 29, Issue:1 | Synthesis, antituberculosis studies and biological evaluation of new quinoline derivatives carrying 1,2,4-oxadiazole moiety. |
| AID566583 | Antimicrobial activity against Staphylococcus xylosus ATCC 2997 by conventional agar-dilution method | 2011 | European journal of medicinal chemistry, Jan, Volume: 46, Issue:1 | Discovery of a novel nitroimidazolyl-oxazolidinone hybrid with potent anti Gram-positive activity: Synthesis and antibacterial evaluation. |
| AID285049 | Antimicrobial activity against Enterococcus raffinosus by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID370032 | Antibacterial activity against methicillin-resistant Staphylococcus aureus COL infected in iv dosed DBA/2 mouse localized infection model assessed as reduction of number of CFU per gram of thigh administered 2 hrs postinfection thrice daily for 1 day and | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vivo efficacy of a novel oxazolidinone compound in two mouse models of infection. |
| AID295154 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus by microdilution broth method | 2007 | European journal of medicinal chemistry, Aug, Volume: 42, Issue:8 | Synthesis and antibacterial activity of oxazolidinones containing triazolyl group. |
| AID1197116 | Antibacterial activity against mecA-positive, methicillin/oxacillin/tetracycline-resistant and vancomycin/linezolid susceptible Staphylococcus aureus COL after 16 to 20 hrs by broth microdilution method | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3 | Structure-activity relationship for the oxadiazole class of antibiotics. |
| AID1407929 | Antibacterial activity against Enterobacter cloacae ARC3528 after 24 hrs by broth microdilution method | 2018 | European journal of medicinal chemistry, Sep-05, Volume: 157 | Discovery of dual GyrB/ParE inhibitors active against Gram-negative bacteria. |
| AID523822 | Antimicrobial activity against oxacillin-resistant coagulase-negative Staphylococcus aureus assessed as inhibition of microbial growth at 4 ug/ml by CLSI method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative activities of TR-700 (torezolid) against staphylococcal blood isolates collected in Spain. |
| AID383563 | Antibacterial activity against vancomycin-resistant Enterococcus faecium ATCC 700221 by broth microdilution technique | 2008 | European journal of medicinal chemistry, Apr, Volume: 43, Issue:4 | Synthesis and in vitro antibacterial activities of novel oxazolidinones. |
| AID542882 | fCmax in Bacillus anthracis infected in vitro hollow fiber PK/PD model at simulated dose of 800 mg administered as 4 divided doses every 6 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID523799 | Antimicrobial activity against linezolid-susceptible Staphylococcus aureus assessed as inhibition of microbial growth at =< 0.25 ug/ml by CLSI method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative activities of TR-700 (torezolid) against staphylococcal blood isolates collected in Spain. |
| AID756094 | Antibacterial activity against methicillin-resistant Staphylococcus aureus assessed as growth inhibition after 16 hrs by agar dilution method | 2013 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 23, Issue:13 | Synthesis and biological evaluation of novel benzoxazinyl-oxazolidinones as potential antibacterial agents. |
| AID1312947 | Bactericidal activity against methicillin-resistant Staphylococcus aureus USA400 NRS123 clinical isolate after 20 hrs by broth microdilution method | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10 | Second-Generation Phenylthiazole Antibiotics with Enhanced Pharmacokinetic Properties. |
| AID576874 | Bactericidal activity against 1 hr peripheral compartment culture samples of Enterococcus faecalis Ef1497 MutM3 in two-compartment pharmacokinetic/pharmacodynamic model assessed as effect on bacterial count at 600 mg, bid administered as 0.5 hr infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID207645 | Antibacterial activity against Staphylococcus aureus UC12673 | 1998 | Bioorganic & medicinal chemistry letters, May-19, Volume: 8, Issue:10 | Synthesis and antibacterial activity of [6,5,5] and [6,6,5] tricyclic fused oxazolidinones. |
| AID530127 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus ATCC 25923 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Pharmacodynamic characterization of ceftobiprole in experimental pneumonia caused by phenotypically diverse Staphylococcus aureus strains. |
| AID1421221 | Antibacterial activity against methicillin-resistant Staphylococcus aureus by broth liquid microdilution method | 2018 | European journal of medicinal chemistry, Oct-05, Volume: 158 | Synthesis and antibacterial activity evaluation of novel biaryloxazolidinone analogues containing a hydrazone moiety as promising antibacterial agents. |
| AID319169 | Plasma concentration in human at 600 mg, po bid | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7 | Linezolid (ZYVOX), the first member of a completely new class of antibacterial agents for treatment of serious gram-positive infections. |
| AID1126492 | Antimicrobial activity against LS2 Efflux knock-out Haemophilus influenzae | 2014 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 24, Issue:8 | Synthesis, antibiotic activity and structure-activity relationship study of some 3-enaminetetramic acids. |
| AID533930 | Antimicrobial activity against linezolid-resistant methicillin-resistant Staphylococcus aureus NRS119 harboring G2576U mutation in peptidyl transferase centre by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains. |
| AID24539 | terminal disposition half-life was evaluated in male Dawley rats at a dose of 10 mg/kg when taken intravenously | 1998 | Journal of medicinal chemistry, Dec-17, Volume: 41, Issue:26 | Nitrogen-carbon-linked (azolylphenyl)oxazolidinones with potent antibacterial activity against the fastidious gram-negative organisms Haemophilus influenzae and Moraxella catarrhalis. |
| AID285088 | Antimicrobial activity against viridans group Streptococcus constellatus at 2 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID1493804 | Antibacterial activity against Staphylococcus aureus USA300 NRS384 clinical isolate after 20 hrs by broth microdilution method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Biphenylthiazole antibiotics with an oxadiazole linker: An approach to improve physicochemical properties and oral bioavailability. |
| AID1271220 | Ratio of Cmax in brain to plasma in BALB/c mouse at 10 mg/kg, po | 2015 | ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11 | Design, Synthesis, and Identification of Silicon Incorporated Oxazolidinone Antibiotics with Improved Brain Exposure. |
| AID542885 | fAUC (24 hrs) in Bacillus anthracis infected in vitro hollow fiber PK/PD model at simulated dose of 800 mg administered as 4 divided doses every 6 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID1303402 | Antibacterial activity against methicillin-resistant Staphylococcus aureus after 24 hrs by microdilution method | 2016 | Bioorganic & medicinal chemistry letters, 07-01, Volume: 26, Issue:13 | Identification of novel aminopiperidine derivatives for antibacterial activity against Gram-positive bacteria. |
| AID745403 | Antibacterial activity against Enterococcus faecium SR7940 clinical isolate assessed as growth inhibition by CLSI broth microdilution method | 2013 | European journal of medicinal chemistry, May, Volume: 63 | Antibacterial oxazolidinone analogues having a N-hydroxyacetyl-substituted seven-membered [1,2,5]triazepane or [1,2,5]oxadiazepane C-ring unit. |
| AID542922 | Antimicrobial activity against Bacillus anthracis infected in in vitro hollow fiber PK/PD model assessed as bacterial killing at 500 mg administered once every 24 hrs for 15 days | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID511429 | Antimicrobial activity against Clostridium perfringens LFM1 assessed as susceptibility breakpoint by DIN-standardized microdilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Resistance to linezolid in a porcine Clostridium perfringens strain carrying a mutation in the rplD gene encoding the ribosomal protein L4. |
| AID1243926 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus USA100 assessed as reduction in bacterial growth incubated for 18 to 20 hrs at 37 degC by broth microdilution method | 2015 | European journal of medicinal chemistry, Aug-28, Volume: 101 | Discovery and characterization of aryl isonitriles as a new class of compounds versus methicillin- and vancomycin-resistant Staphylococcus aureus. |
| AID285097 | Antimicrobial activity against viridans group Streptococcus intermedius at 0.5 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID292669 | Antibacterial activity against Staphylococcus aureus by broth microdilution method | 2007 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 17, Issue:18 | A distal methyl substituent attenuates mitochondrial protein synthesis inhibition in oxazolidinone antibacterials. |
| AID373993 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus 547 after 14 passages with CG400549 measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID528969 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus isolated from ICU patient respiratory tract assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID499143 | Ratio of fAUC to MIC in Staphylococcus aureus OC 8525 infected sc dosed SKH1 mouse | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vivo activity of ceftobiprole in murine skin infections due to Staphylococcus aureus and Pseudomonas aeruginosa. |
| AID498884 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus OC 8525 assessed as inhibition of growth by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vivo activity of ceftobiprole in murine skin infections due to Staphylococcus aureus and Pseudomonas aeruginosa. |
| AID285009 | Antimicrobial activity against Enterococcus hirae at 0.25 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID340860 | Antimicrobial activity against vancomycin-intermediate resistant Staphylococcus aureus Mu50 vraG mutant microdilution assay | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Interaction of the GraRS two-component system with the VraFG ABC transporter to support vancomycin-intermediate resistance in Staphylococcus aureus. |
| AID270151 | Antibacterial activity against gram positive Staphylococcus aureus Smith OC 4172 in presence of 50% mouse serum | 2006 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 16, Issue:17 | Antibacterial activity of pyrrolopyridine-substituted oxazolidinones: synthesis and in vitro SAR of various C-5 acetamide replacements. |
| AID519987 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus nosocomial isolate | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID1609275 | Bactericidal activity against methicilline-resistant Staphylococcus aureus NRS384 USA300 incubated for 18 to 20 hrs followed by replating on tryptic soy agar plate and further incubated for 18 to 24 hrs by CLSI-based broth microdilution assay | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Phenylthiazoles with nitrogenous side chain: An approach to overcome molecular obesity. |
| AID311483 | Antimicrobial activity against Haemophilus influenzae ATCC 49247 after 14 to 16 hrs by serial micro-broth dilution method | 2007 | Journal of natural products, Sep, Volume: 70, Issue:9 | Lipoxazolidinones A, B, and C: antibacterial 4-oxazolidinones from a marine actinomycete isolated from a Guam marine sediment. |
| AID532800 | Antibacterial activity against vancomycin-susceptible Staphylococcus aureus PC after 24 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Improved antimicrobial activity of linezolid against vancomycin-intermediate Staphylococcus aureus. |
| AID582989 | Antimicrobial activity against glycopeptide-resistant Enterococcus faecalis isolate HS0847 harboring MLST sequence type ST78 and pulsotype E expressing vanM gene cluster isolated from urine of patient by Etest | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | vanM, a new glycopeptide resistance gene cluster found in Enterococcus faecium. |
| AID424424 | Antibacterial activity against vancomycin-resistant Staphylococcus aureus AIS2006032 isolated from patients foot wound by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Vancomycin-resistant Staphylococcus aureus isolates associated with Inc18-like vanA plasmids in Michigan. |
| AID573861 | Antibacterial activity against community-associated methicillin-resistant Staphylococcus aureus OC8525 after 16 to 20 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | In vivo activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. |
| AID1352009 | Antibacterial activity against wild type Staphylococcus aureus Newman infected in BALB/c mouse assessed as decrease in bacterial load in mouse liver at 0.4 mg, ip bid administered 4.5 days measured after 90 hrs relative to control | 2018 | European journal of medicinal chemistry, Feb-10, Volume: 145 | Discovery of novel piperonyl derivatives as diapophytoene desaturase inhibitors for the treatment of methicillin-, vancomycin- and linezolid-resistant Staphylococcus aureus infections. |
| AID1680043 | Antibacterial activity against NDM1 producing carbapenem-resistant Enterobacteriaceae clinical isolate 3 assessed as reduction in bacterial growth incubated for 16 to 20 hrs by CLSI-based broth microdilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Synthesis and antibacterial bioactivities of cationic deacetyl linezolid amphiphiles. |
| AID523814 | Antimicrobial activity against oxacillin-susceptible coagulase-negative Staphylococcus aureus assessed as inhibition of microbial growth at =< 0.25 ug/ml by CLSI method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative activities of TR-700 (torezolid) against staphylococcal blood isolates collected in Spain. |
| AID1252239 | Antimicrobial activity against Acinetobacter baumannii ATCC 19606 | 2015 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 25, Issue:21 | Rapid synthesis and antimicrobial activity of novel 4-oxazolidinone heterocycles. |
| AID370015 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus Smith infected in C3H mouse assessed as mortality at 25 mg/kg/day, iv administered within 15 mins of infection measured after 48 hrs by organ burden assay relative to control | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vivo efficacy of a novel oxazolidinone compound in two mouse models of infection. |
| AID1553382 | Inhibition of CYP2C19 (unknown origin) | 2019 | Bioorganic & medicinal chemistry letters, 09-15, Volume: 29, Issue:18 | Incorporation of a chiral gem-disubstituted nitrogen heterocycle yields an oxazolidinone antibiotic with reduced mitochondrial toxicity. |
| AID567455 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus CGK7 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Development of daptomycin nonsusceptibility with heterogeneous vancomycin-intermediate resistance and oxacillin susceptibility in methicillin-resistant Staphylococcus aureus during high-dose daptomycin treatment. |
| AID374013 | Antimicrobial activity against methicillin-resistant vancomycin-intermediate Staphylococcus aureus 555 after single-step resistance selection by agar dilution CLSI method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID1692401 | Antibacterial activity against methicillin resistant and vancomycin intermediate resistant Staphylococcus aureus MU50 assessed as reduction in bacterial growth incubated for 18 to 24 hrs by broth microdilution method | 2020 | European journal of medicinal chemistry, Aug-15, Volume: 200 | Pharmacomodulations of the benzoyl-thiosemicarbazide scaffold reveal antimicrobial agents targeting d-alanyl-d-alanine ligase in bacterio. |
| AID1271222 | Ratio of AUC (0 to infinity) in brain to plasma in BALB/c mouse at 10 mg/kg, po | 2015 | ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11 | Design, Synthesis, and Identification of Silicon Incorporated Oxazolidinone Antibiotics with Improved Brain Exposure. |
| AID575084 | Antimicrobial activity against multiple drug resistant Streptococcus pneumoniae serotype 6B assessed as percent susceptible isolates by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID1904914 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus NRS 107 incubated for 18 to 20 hrs by broth microdilution method | 2022 | European journal of medicinal chemistry, Apr-15, Volume: 234 | Exploring the structure-activity relationships of diphenylurea as an antibacterial scaffold active against methicillin- and vancomycin-resistant Staphylococcus aureus. |
| AID285353 | Decrease in Panton-Valentine leukocidin level in community acquired methicillin-resistant Staphylococcus aureus HT20010734 in CYY medium | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Effect of antibiotics on Staphylococcus aureus producing Panton-Valentine leukocidin. |
| AID308918 | Antibacterial activity against Staphylococcus aureus ATCC 33592 by broth microdilution method | 2007 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 17, Issue:18 | Synthesis and in vitro antibacterial activity of novel methylamino piperidinyl oxazolidinones. |
| AID285042 | Antimicrobial activity against Corynebacterium pseudodiphtheriticum by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID542910 | Antimicrobial activity against Bacillus anthracis infected in in vitro hollow fiber PK/PD model assessed as cell killing at 200 mg administered once every 24 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID1414211 | Toxicity in mouse infected with methicillin-resistant Staphylococcus aureus ATCC 43300 assessed as mouse death at 30 mg/kg, ip administered 0.1, 6 hrs postinfection and measured after 1 week | 2018 | European journal of medicinal chemistry, Nov-05, Volume: 159 | Design, synthesis and structure-based optimization of novel isoxazole-containing benzamide derivatives as FtsZ modulators. |
| AID630562 | Antibacterial activity against linezolid-resistant Enterococcus faecium after 16 hrs by agar dilution method | 2011 | Journal of medicinal chemistry, Nov-10, Volume: 54, Issue:21 | Design, synthesis, and structure-activity relationship studies of highly potent novel benzoxazinyl-oxazolidinone antibacterial agents. |
| AID637977 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after overnight incubation by twofold broth dilution technique in presence of 50% human serum | 2012 | Bioorganic & medicinal chemistry, Jan-01, Volume: 20, Issue:1 | Efficient microwave-assisted synthesis, antibacterial activity and high fluorescence of 5 benzimidazolyl-2'-deoxyuridines. |
| AID373832 | Antimicrobial activity against panton-valentine leukocidin-positive community-acquired methicillin-resistant Staphylococcus aureus 490 after 23 passages with quinupristin-dalfopristin measured after 10 antibiotic-free subculture by multi-step resistance s | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID370040 | Bioavailability in Staphylococcus aureus-infected mouse localized thigh infection model at 25 mg/kg | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vivo efficacy of a novel oxazolidinone compound in two mouse models of infection. |
| AID1472759 | In vivo anti-virulence activity against methicillin-resistant Staphylococcus aureus LRSA202 infected in BALB/c mouse model assessed as reduction in bacterial load in kidney at 0.4 mg bid for 3.5 days administered intraperitoneally 6 hrs post infection by | 2018 | Journal of medicinal chemistry, 01-11, Volume: 61, Issue:1 | Novel Terminal Bipheny-Based Diapophytoene Desaturases (CrtN) Inhibitors as Anti-MRSA/VISR/LRSA Agents with Reduced hERG Activity. |
| AID525143 | Antimicrobial activity against linezolid-resistant Staphylococcus aureus isolate 004-737X expressing cfr and ermA gene isolated from paraplegic patient by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | First report of cfr-mediated resistance to linezolid in human staphylococcal clinical isolates recovered in the United States. |
| AID565230 | Antimicrobial activity against Mycobacterium chelonae 9917 by resazurine microtiter assay | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Role of porins in the susceptibility of Mycobacterium smegmatis and Mycobacterium chelonae to aldehyde-based disinfectants and drugs. |
| AID559362 | Antimicrobial activity against compound-intermediate susceptible Coxiella burnetii Q212 obtained from patient with acute Q fever infected in african green monkey Vero cells after 24 hrs by shell vial assay | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Bacteriostatic and bactericidal activities of tigecycline against Coxiella burnetii and comparison with those of six other antibiotics. |
| AID583879 | Antibacterial activity against laboratory-derived Staphylococcus aureus isolate 29213-1 harboring ribosomal protein L3 Gly155Arg mutant and cfr-containing p42262 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Elevated linezolid resistance in clinical cfr-positive Staphylococcus aureus isolates is associated with co-occurring mutations in ribosomal protein L3. |
| AID1770386 | Inhibition of Bacillus subtilis FtsZ assessed as promotion of FtsZ polymerization at 10 ug/ml measured after 10 hrs by fluorescence spectrometer based light scattering assay | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Modification of 5-methylphenanthridium from benzothiazoles to indoles as potent FtsZ inhibitors: Broadening the antibacterial spectrum toward vancomycin-resistant enterococci. |
| AID363430 | Antibacterial activity against Staphylococcus aureus ATCC 29213 in absence of human serum | 2008 | Journal of medicinal chemistry, Sep-11, Volume: 51, Issue:17 | Novel dual-targeting benzimidazole urea inhibitors of DNA gyrase and topoisomerase IV possessing potent antibacterial activity: intelligent design and evolution through the judicious use of structure-guided design and structure-activity relationships. |
| AID1778643 | Antibacterial activity against penicillin-susceptible Bacillus subtilis ATCC 9372 assessed as bacterial growth inhibition incubated for 24 hrs by CLSI protocol based broth microdilution method | 2021 | European journal of medicinal chemistry, Oct-05, Volume: 221 | Design, synthesis and evaluation of novel 9-arylalkyl-10-methylacridinium derivatives as highly potent FtsZ-targeting antibacterial agents. |
| AID424425 | Antibacterial activity against Enterococcus faecalis AIS2007003 isolated from patients rectum by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Vancomycin-resistant Staphylococcus aureus isolates associated with Inc18-like vanA plasmids in Michigan. |
| AID522891 | Antibacterial activity against vancomycin-intermediate Staphylococcus aureus isolate 1008 after 24 hrs by modified broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Antistaphylococcal activity of ACHN-490 tested alone and in combination with other agents by time-kill assay. |
| AID1056351 | Antibacterial activity against methicillin-resistant Staphylococcus aureus SR3637 clinical isolate infected in iv dosed JCL/ICR systemic infection model assessed as mortality administered after 1 hr of infection measured for 7 days | 2013 | ACS medicinal chemistry letters, Nov-14, Volume: 4, Issue:11 | Potent oxazolidinone antibacterials with heteroaromatic C-ring substructure. |
| AID368283 | Half life in rabbit plasma at 58 mg/kg infused every 12 hrs for 4 days | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vivo efficacy of ceftaroline (PPI-0903), a new broad-spectrum cephalosporin, compared with linezolid and vancomycin against methicillin-resistant and vancomycin-intermediate Staphylococcus aureus in a rabbit endocarditis model. |
| AID373834 | Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus 504 after 14 passages with CG400549 measured after 10 times antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID763984 | Antibacterial activity against methicillin-susceptible coagulase-negative Staphylococcus after 18 hrs by NCCLS agar dilution method | 2013 | European journal of medicinal chemistry, Aug, Volume: 66 | Synthesis and antibacterial activities of N-substituted-glycinyl 1H-1,2,3-triazolyl oxazolidinones. |
| AID1269334 | Apparent permeability from basolateral to apical side in human Caco2 cells | 2016 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 26, Issue:2 | Synthesis and evaluation of pretomanid (PA-824) oxazolidinone hybrids. |
| AID311480 | Antimicrobial activity against penicillin-resistant Streptococcus pneumoniae ATCC 51915 after 14 to 16 hrs by serial micro-broth dilution method | 2007 | Journal of natural products, Sep, Volume: 70, Issue:9 | Lipoxazolidinones A, B, and C: antibacterial 4-oxazolidinones from a marine actinomycete isolated from a Guam marine sediment. |
| AID349310 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus clinical isolate after 18 hrs by agar dilution method | 2008 | European journal of medicinal chemistry, May, Volume: 43, Issue:5 | Synthesis and structure-antibacterial activity of triazolyl oxazolidinones containing long chain acyl moiety. |
| AID475009 | Antibacterial activity against Klebsiella pneumoniae LCB0014 by two fold serial dilution method | 2010 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 20, Issue:7 | Synthesis, crystal and antibacterial studies of diversely functionalized tetrahydropyridin-4-ol. |
| AID573144 | Antibacterial activity against penicillin-susceptible Streptococcus viridans assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID566570 | Antimicrobial activity against Corynebacterium glutamicum ATCC 13032 by conventional agar-dilution method | 2011 | European journal of medicinal chemistry, Jan, Volume: 46, Issue:1 | Discovery of a novel nitroimidazolyl-oxazolidinone hybrid with potent anti Gram-positive activity: Synthesis and antibacterial evaluation. |
| AID1243932 | Antimicrobial activity against vancomycin-intermediate-resistant Staphylococcus aureus NRS1 assessed as reduction in bacterial growth incubated for 18 to 20 hrs at 37 degC by broth microdilution method | 2015 | European journal of medicinal chemistry, Aug-28, Volume: 101 | Discovery and characterization of aryl isonitriles as a new class of compounds versus methicillin- and vancomycin-resistant Staphylococcus aureus. |
| AID410116 | Antimicrobial activity against Haemophilus influenzae A1950 by NCCLS method | 2008 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 18, Issue:23 | Design at the atomic level: design of biaryloxazolidinones as potent orally active antibiotics. |
| AID1197118 | Antibacterial activity against mecA-positive, ciprofloxacin/gentamicin/oxacillin/penicillin/linezolid-resistant Staphylococcus aureus NRS120 after 16 to 20 hrs by broth microdilution method | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3 | Structure-activity relationship for the oxadiazole class of antibiotics. |
| AID558717 | Antimicrobial activity against heterogeneous vancomycin-intermediate Staphylococcus aureus 168 measured on day 45 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID1161141 | Antimicrobial activity against Escherichia coli isolate 1 after 24 hrs by broth microdilution method | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | Synthesis, antibacterial activity, and biological evaluation of formyl hydroxyamino derivatives as novel potent peptide deformylase inhibitors against drug-resistant bacteria. |
| AID560803 | AUC (0 to 24 hrs) in human adults with pulmonary tuberculosis at 600 mg administered daily for 7 days | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Population pharmacokinetics of linezolid in adults with pulmonary tuberculosis. |
| AID542682 | fAUC (24 hrs) in Bacillus anthracis infected in vitro hollow fiber PK/PD model at simulated dose of 300 mg administered every 24 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID560801 | Apparent volume of distribution with respect to the bioavailability in human adults with pulmonary tuberculosis at 600 mg administered daily for 7 days | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Population pharmacokinetics of linezolid in adults with pulmonary tuberculosis. |
| AID66113 | In vitro antibacterial activity against Enterococcus faecalis NCTC 12201 (E. f. 153) vancomycin resistant | 2002 | Journal of medicinal chemistry, Aug-29, Volume: 45, Issue:18 | Synthesis of conformationally constrained analogues of linezolid: structure-activity relationship (SAR) studies on selected novel tricyclic oxazolidinones. |
| AID67894 | The compound was evaluated for its anti-bacterial activity against Enterococcus faecalis UC 9217 | 1998 | Journal of medicinal chemistry, Dec-17, Volume: 41, Issue:26 | Nitrogen-carbon-linked (azolylphenyl)oxazolidinones with potent antibacterial activity against the fastidious gram-negative organisms Haemophilus influenzae and Moraxella catarrhalis. |
| AID1167730 | Solubility of the compound | 2014 | Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21 | Novel DNA gyrase inhibiting spiropyrimidinetriones with a benzisoxazole scaffold: SAR and in vivo characterization. |
| AID560831 | Ratio of AUC (0 to 24 hrs) in human adults with pulmonary tuberculosis at 600 mg administered twice daily for 5 days to MIC for Mycobacterium tuberculosis | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Population pharmacokinetics of linezolid in adults with pulmonary tuberculosis. |
| AID1151739 | Antibacterial activity against Staphylococcus aureus measured after 1 serial passage | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID1269336 | Plasma protein binding in human | 2016 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 26, Issue:2 | Synthesis and evaluation of pretomanid (PA-824) oxazolidinone hybrids. |
| AID244822 | Minimal inhibitory concentration against Bacillus cereus | 2004 | Bioorganic & medicinal chemistry letters, Sep-20, Volume: 14, Issue:18 | Synthesis and antibacterial activity of some aryloxy/thioaryloxy oxazolidinone derivatives. |
| AID520026 | Antimicrobial activity against Enterococcus faecium A5959 | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID1680042 | Antibacterial activity against NDM1 producing carbapenem-resistant Enterobacteriaceae clinical isolate 4 assessed as reduction in bacterial growth incubated for 16 to 20 hrs by CLSI-based broth microdilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Synthesis and antibacterial bioactivities of cationic deacetyl linezolid amphiphiles. |
| AID308915 | Antibacterial activity against Enterococcus faecalis ATCC 14506 by broth microdilution method | 2007 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 17, Issue:18 | Synthesis and in vitro antibacterial activity of novel methylamino piperidinyl oxazolidinones. |
| AID79584 | Inhibitory activity against Haemophilus influenzae UC30063 | 2000 | Journal of medicinal chemistry, Mar-09, Volume: 43, Issue:5 | Substituent effects on the antibacterial activity of nitrogen-carbon-linked (azolylphenyl)oxazolidinones with expanded activity against the fastidious gram-negative organisms Haemophilus influenzae and Moraxella catarrhalis. |
| AID564133 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus HUSA 304 infected in Wistar rat assessed as decrease in bacterial load in tissue cage fluid at 50 mg/kg, ip administered every 12 hrs for 7 days measured on day 11 post treatment | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | Efficacy of high doses of daptomycin versus alternative therapies against experimental foreign-body infection by methicillin-resistant Staphylococcus aureus. |
| AID1168017 | Antibacterial activity against vancomycin-resistant Enterococcus faecium clinical isolate 8/224 after overnight incubation by two-fold serial dilution method | 2014 | Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21 | Synthesis and biological evaluation of novel peptide BF2 as an antibacterial agent against clinical isolates of vancomycin-resistant enterococci. |
| AID583705 | Antibacterial activity against clinical-derived Staphylococcus aureus isolate 42262 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Elevated linezolid resistance in clinical cfr-positive Staphylococcus aureus isolates is associated with co-occurring mutations in ribosomal protein L3. |
| AID483191 | Antibacterial activity against Staphylococcus aureus ATCC 25923 by microbroth dilution technique | 2010 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 20, Issue:12 | Design, synthesis, and antibacterial activity of 2,5-dihydropyrrole formyl hydroxyamino derivatives as novel peptide deformylase inhibitors. |
| AID1194835 | Antibacterial activity against methicillin-resistant Staphylococcus epidermidis incubated for 16 hrs by agar dilution method | 2015 | Bioorganic & medicinal chemistry letters, , Volume: 25, Issue:10 | Synthesis and structure-activity relationship studies of novel [6,6,5] tricyclic oxazolidinone derivatives as potential antibacterial agents. |
| AID1414193 | Antibacterial activity against Escherichia coli ATCC 25922 after 24 hrs by broth microdilution based CLSI method | 2018 | European journal of medicinal chemistry, Nov-05, Volume: 159 | Design, synthesis and structure-based optimization of novel isoxazole-containing benzamide derivatives as FtsZ modulators. |
| AID1723532 | Antibacterial activity against Enterococcus faecium NR-31972 incubated for 18 to 20 hrs under aerobic condition by CLSI protocol based broth microdilution assay | |||
| AID205738 | In vitro antibacterial activity against methicillin resistant Staphylococcus epidermidis UC 12084; range is 1-2 | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | The synthesis and antibacterial activity of 1,3,4-thiadiazole phenyl oxazolidinone analogues. |
| AID244961 | Minimal inhibitory concentration against Pseudomonas aeruginosa ATCC 27853 | 2004 | Bioorganic & medicinal chemistry letters, Sep-20, Volume: 14, Issue:18 | Synthesis and antibacterial activity of some aryloxy/thioaryloxy oxazolidinone derivatives. |
| AID1710580 | Antibacterial activity against methicillin-resistant Staphylococcus aureus NRS386 assessed as inhibition of visible bacterial growth incubated for 18 to 20 hrs by CLSI method | 2020 | RSC medicinal chemistry, Jan-01, Volume: 11, Issue:1 | Potent trifluoromethoxy, trifluoromethylsulfonyl, trifluoromethylthio and pentafluorosulfanyl containing (1,3,4-oxadiazol-2-yl)benzamides against drug-resistant Gram-positive bacteria. |
| AID575169 | Inhibition of acrAB AcrAB-TolC-mediated Nile Red efflux in Escherichia coli K-12 3-AG100 overexpressing acrAB AcrAB-TolC assessed as time needed for 50% efflux after energization with 50 mM glucose at 1000 uM by spectrofluorometric assay | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Optimized Nile Red efflux assay of AcrAB-TolC multidrug efflux system shows competition between substrates. |
| AID67384 | In vitro antibacterial activity against vancomycin resistant Enterococcus faecalis UC 9217 (VREA); range is 1-2 | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | The synthesis and antibacterial activity of 1,3,4-thiadiazole phenyl oxazolidinone analogues. |
| AID695445 | Antibacterial activity against fluoroquinolone resistant Staphylococcus aureus 4-FQR3M BSA643 expressing GyrA Ser84Leu mutant and GrlA Ser80Tyr and Glu84Gly mutant | 2011 | Journal of medicinal chemistry, May-12, Volume: 54, Issue:9 | Selenophene-containing inhibitors of type IIA bacterial topoisomerases. |
| AID1400039 | Bactericidal activity against Staphylococcus aureus ATCC 25923 incubated for 24 hrs under aerobic condition by MABA | 2018 | Bioorganic & medicinal chemistry, 09-15, Volume: 26, Issue:17 | An antimycobacterial pleuromutilin analogue effective against dormant bacilli. |
| AID1437030 | Antimycobacterial activity against isoniazid/rifampicin/kanamycin/capreomycin-resistant Mycobacterium tuberculosis by microplate Alamar Blue assay | 2017 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 27, Issue:4 | Development of gallic acid formazans as novel enoyl acyl carrier protein reductase inhibitors for the treatment of tuberculosis. |
| AID1520443 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus after 18 to 20 hrs by CLSI-protocol based broth microdilution method | |||
| AID1723491 | Antibacterial activity against Enterococcus faecium HM968 incubated for 18 to 20 hrs under aerobic condition by CLSI protocol based broth microdilution assay | |||
| AID522890 | Antibacterial activity against vancomycin-intermediate Staphylococcus aureus isolate 770 after 24 hrs by modified broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Antistaphylococcal activity of ACHN-490 tested alone and in combination with other agents by time-kill assay. |
| AID541068 | Half life in cage fluid of Albino guiena pig at 50 mg/kg, ip | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Linezolid alone or combined with rifampin against methicillin-resistant Staphylococcus aureus in experimental foreign-body infection. |
| AID523813 | Antimicrobial activity against linezolid-susceptible coagulase-negative Staphylococcus assessed as inhibition of microbial growth at 4 ug/ml by CLSI method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative activities of TR-700 (torezolid) against staphylococcal blood isolates collected in Spain. |
| AID573878 | Bacteriostatic activity against methicillin-susceptible Staphylococcus aureus Smith ATCC 13709 infected in SKH1 mouse upto 320 mg/kg/day, po administered post infection measured after 48 hrs | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | In vivo activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. |
| AID583895 | Antibacterial activity against vancomycin-intermediate Staphylococcus aureus isolate 453 (NRS23) by broth microdilution assay | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Comparative efficacies of human simulated exposures of telavancin and vancomycin against methicillin-resistant Staphylococcus aureus with a range of vancomycin MICs in a murine pneumonia model. |
| AID373657 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus 547 by agar dilution CLSI method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID560377 | Selectivity ratio of MIC for Enterococcus faecalis 1058946 in presence of 4% HSA to MIC for Enterococcus faecalis 1058946 | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Impact of human serum albumin on oritavancin in vitro activity against enterococci. |
| AID1852687 | Antibacterial activity against efflux pump lacking/recombinant OM pore producing Pseudomonas aeruginosa assessed as inhibition of bacterial growth | |||
| AID608938 | Antibacterial activity against Escherichia coli ATCC 8739 after 24 hrs by broth microdilution method | 2011 | European journal of medicinal chemistry, Jul, Volume: 46, Issue:7 | A regioselective synthesis of some new pyrazol-1'-ylpyrazolo[1,5-a]pyrimidines in aqueous medium and their evaluation as antimicrobial agents. |
| AID171360 | Dawley rats at a dose of 10 mg/kg when taken intravenously | 1998 | Journal of medicinal chemistry, Dec-17, Volume: 41, Issue:26 | Nitrogen-carbon-linked (azolylphenyl)oxazolidinones with potent antibacterial activity against the fastidious gram-negative organisms Haemophilus influenzae and Moraxella catarrhalis. |
| AID1079932 | Highest frequency of moderate liver toxicity observed during clinical trials, expressed as a percentage. [column '% BIOL' in source] | |||
| AID304005 | Effect on hematology in Sprague-Dawley rat assessed as decrease in hemoglobin at 200 mg/kg/day, po after 14 days | 2007 | Journal of medicinal chemistry, Nov-29, Volume: 50, Issue:24 | Antibacterial oxazolidinones possessing a novel C-5 side chain. (5R)-trans-3-[3-Fluoro-4- (1-oxotetrahydrothiopyran-4-yl)phenyl]-2- oxooxazolidine-5-carboxylic acid amide (PF-00422602), a new lead compound. |
| AID444260 | Antibacterial activity against methicillin-resistant Staphylococcus aureus 562 by NCCLS method | 2009 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 19, Issue:22 | Synthesis and biological activity of novel oxazolidinones. |
| AID576666 | Bactericidal activity against 0.5 hrs peripheral compartment culture samples of Enterococcus faecalis Ef1497 in two-compartment pharmacokinetic/pharmacodynamic model assessed as effect on bacterial count at 600 mg, bid administered as 0.5 hr infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID283625 | Antimicrobial activity against Enterococcus faecium Ho 4136-0042 | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | In vitro activity of the oxazolidinone RWJ-416457 against linezolid-resistant and -susceptible staphylococci and enterococci. |
| AID206591 | In vitro antibacterial activity against Staphylococcus aureus 77 (S.a.2) | 2003 | Bioorganic & medicinal chemistry letters, Nov-17, Volume: 13, Issue:22 | Synthesis and in vitro activity of novel isoxazolyl tetrahydropyridinyl oxazolidinone antibacterial agents. |
| AID522913 | Antibacterial activity against hospital-acquired methicillin-resistant Staphylococcus aureus isolate 1806 after 24 hrs by modified broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Antistaphylococcal activity of ACHN-490 tested alone and in combination with other agents by time-kill assay. |
| AID1539446 | Antibacterial activity against Methicillin-resistant Staphylococcus aureus NRS123-USA400 clinical isolates after 18 to 20 hrs in aerobic condition by CLSI protocol based broth microdilution assay | |||
| AID274224 | Antibacterial activity against Staphylococcus aureus UC-76 SA-1 | 2006 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 16, Issue:20 | Synthesis and structure-activity studies of novel benzocycloheptanone oxazolidinone antibacterial agents. |
| AID520511 | Cmax in New Zealand rabbit osteomyelitis model at 40 mg/kg, sc administered every 6 hrs for 4 days | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Efficacies of ceftobiprole medocaril and comparators in a rabbit model of osteomyelitis due to methicillin-resistant Staphylococcus aureus. |
| AID533944 | Antimicrobial activity against linezolid-resistant Enterococcus faecalis 1172 harboring G2576U mutation in peptidyl transferase centre by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains. |
| AID576675 | Bactericidal activity against 0.5 hrs peripheral compartment culture samples of Enterococcus faecalis Ef1497 in two-compartment pharmacokinetic/pharmacodynamic model assessed as effect on bacterial count at 800 mg, bid administered as 0.5 hr infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID528837 | Antimicrobial activity against vancomycin-resistant Enterococcus sp. isolated from ICU patient urine assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID1367593 | Antibacterial activity against gram-negative Escherichia coli MG1655 membrane permeabilized mutant in presence of polymyxinnonapeptide by CLSI broth microdilution method | 2017 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23 | Compound design guidelines for evading the efflux and permeation barriers of Escherichia coli with the oxazolidinone class of antibacterials: Test case for a general approach to improving whole cell Gram-negative activity. |
| AID576673 | Bactericidal activity against 24 hrs peripheral compartment culture samples of Enterococcus faecalis Ef1497 in two-compartment pharmacokinetic/pharmacodynamic model assessed as effect on bacterial count at 600 mg, bid administered as 0.5 hr infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID85979 | In vitro antibacterial activity against ampicillin resistant Haemophilus influenzae 30063 (B-lactamase +) | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | The synthesis and antibacterial activity of 1,3,4-thiadiazole phenyl oxazolidinone analogues. |
| AID555509 | Antibacterial activity against methicillin-resistant, vancomycin-intermediate coagulase-negative Staphylococcus epidermidis 225 after 50 passages by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Antistaphylococcal activity of dihydrophthalazine antifolates, a family of novel antibacterial drugs. |
| AID559562 | Antimicrobial activity against compound-resistant Coxiella burnetii isolate CP8 obtained from patient with acute Q fever infected in african green monkey Vero cells after 24 hrs by shell vial assay | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Bacteriostatic and bactericidal activities of tigecycline against Coxiella burnetii and comparison with those of six other antibiotics. |
| AID206227 | In vitro antibacterial activity against Staphylococcus epidermis C2235 | 2003 | Bioorganic & medicinal chemistry letters, Jul-07, Volume: 13, Issue:13 | Synthesis and in vitro activity of new methylenepiperidinyl and methylenepyrrolidinyl oxazolidinone antibacterial agents. |
| AID283176 | Increase in biofilm formation of Staphylococcus aureus SA113 at 0.25 times MIC | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | In vitro effects of antimicrobial agents on planktonic and biofilm forms of Staphylococcus lugdunensis clinical isolates. |
| AID571926 | Antimicrobial activity against Escherichia coli K-12 3-AG300 harboring AcrB-N623S-Q624S mutant gene | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Site-directed mutagenesis reveals amino acid residues in the Escherichia coli RND efflux pump AcrB that confer macrolide resistance. |
| AID1407927 | Antibacterial activity against Klebsiella pneumoniae ARC1865 after 24 hrs by broth microdilution method | 2018 | European journal of medicinal chemistry, Sep-05, Volume: 157 | Discovery of dual GyrB/ParE inhibitors active against Gram-negative bacteria. |
| AID558709 | Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus 555 measured on day 40 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID319984 | Antimicrobial activity against vancomycin-sensitive Enterococcus faecalis ATCC 29212 | 2008 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 18, Issue:2 | Synthesis, SAR, and antibacterial activity of novel oxazolidinone analogues possessing urea functionality. |
| AID533115 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus N315DeltaIP by Etest method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Serial daptomycin selection generates daptomycin-nonsusceptible Staphylococcus aureus strains with a heterogeneous vancomycin-intermediate phenotype. |
| AID567567 | Antimicrobial activity against Bacillus sp. BS-01 expressing multiple resistance gene cfr and phenolic resistance gene fexA obtained from swine feces | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | First report of the multidrug resistance gene cfr and the phenicol resistance gene fexA in a Bacillus strain from swine feces. |
| AID576899 | Ratio of AUC (0 to 24 hrs) to MIC for Staphylococcus aureus RN4220 MutS2 in two-compartment pharmacokinetic/pharmacodynamic model at 600 mg, bid administered as 0.5 hr infusion for 2 days | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID1660514 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 33591 after 16 hrs by CLSI-based broth microdilution method | 2020 | Journal of natural products, 06-26, Volume: 83, Issue:6 | Synthesis of the Cyanobacterial Antibiotics Anaephenes A and B. |
| AID268863 | Antibacterial activity against Staphylococcus aureus ATCC 29213 | 2006 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 16, Issue:16 | Synthesis of novel tricyclic oxazolidinones by a tandem SN2 and SNAr reaction: SAR studies on conformationally constrained analogues of Linezolid. |
| AID532814 | Antibacterial activity against vancomycin-intermediate Staphylococcus aureus NJ phenotypic revertant after 24 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Improved antimicrobial activity of linezolid against vancomycin-intermediate Staphylococcus aureus. |
| AID533024 | Antibacterial activity against vancomycin-susceptible Staphylococcus aureus N315-LR5-P1-4 assessed as inhibition of bacterial growth in brain heart infusion broth medium | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Improved antimicrobial activity of linezolid against vancomycin-intermediate Staphylococcus aureus. |
| AID285377 | Bactericidal activity against vancomycin-intermediate Staphylococcus aureus Mu50 assessed as reduction of CFU using in vitro PK/PD model with human dosage regimen 600 mg every 12 hrs after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Pharmacokinetic/pharmacodynamic factors influencing emergence of resistance to linezolid in an in vitro model. |
| AID560362 | Antimicrobial activity against vancomycin-susceptible Enterococcus faecalis ATCC 29212 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Impact of human serum albumin on oritavancin in vitro activity against enterococci. |
| AID569345 | Antibacterial activity against methicillin-resistant Staphylococcus epidermidis by agar dilution method | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 | Design, synthesis and antibacterial activity of 3-methylenepyrrolidine formyl hydroxyamino derivatives as novel peptide deformylase inhibitors. |
| AID548472 | Antibacterial activity against vancomycin-susceptible Staphylococcus aureus Mu50omega after 48 hrs by Etest | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Contribution of vraSR and graSR point mutations to vancomycin resistance in vancomycin-intermediate Staphylococcus aureus. |
| AID370042 | Antibacterial activity against linezolid-resistant methicillin-resistant Staphylococcus aureus infected in C3H mouse localized infection model assessed as log reduction in CFU per gram of thigh at 100 mg/kg measured after 48 hrs by organ burden assay rela | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vivo efficacy of a novel oxazolidinone compound in two mouse models of infection. |
| AID410208 | Antibacterial activity against Enterococcus faecium by broth micro dilution method | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24 | A facile synthesis, antibacterial, and antitubercular studies of some piperidin-4-one and tetrahydropyridine derivatives. |
| AID753114 | Antibacterial activity against 16-membered ring macrolide- lincosamide-streptogramin B-resistant Staphylococcus MTCC 2940 assessed as growth inhibition at 20 mg/mL after 24 hrs | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | Anti-tubercular agents. Part 7: a new class of diarylpyrrole-oxazolidinone conjugates as antimycobacterial agents. |
| AID285547 | Plasma half life in mouse at 20 mg/kg, sc | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | In vitro and in vivo antibacterial activities of heteroaryl isothiazolones against resistant gram-positive pathogens. |
| AID617586 | Antibacterial activity against Staphylococcus aureus ATCC 25923 by CLSI method | 2011 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 21, Issue:18 | Synthesis and in vitro activity of novel 1,2,4-triazolo[4,3-a]pyrimidine oxazolidinone antibacterial agents. Part II. |
| AID1721056 | Antitubercular activity against Mycobacterium tuberculosis H37Rv infected in Balb/c mouse assessed as lung bacterial burden by measuring colony forming unit at 100 mg/kg/day, po administered via gavage 5 times per week for 3 weeks starting from 10 days po | 2020 | Journal of medicinal chemistry, 09-10, Volume: 63, Issue:17 | Discovery of a Conformationally Constrained Oxazolidinone with Improved Safety and Efficacy Profiles for the Treatment of Multidrug-Resistant Tuberculosis. |
| AID319987 | Antimicrobial activity against vancomycin-resistant Enterococcus faecium ATCC 12202 infected in po dosed mouse | 2008 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 18, Issue:2 | Synthesis, SAR, and antibacterial activity of novel oxazolidinone analogues possessing urea functionality. |
| AID392202 | Antibacterial activity against Streptococcus pneumoniae SV1 SP-3 by micro broth method | 2009 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 19, Issue:2 | Synthesis and structure-activity studies of novel homomorpholine oxazolidinone antibacterial agents. |
| AID245295 | In vitro minimum inhibitory concentration of compound against Methicillin-resistant Staphylococcus aureus ATCC 29213 | 2005 | Bioorganic & medicinal chemistry letters, Jan-17, Volume: 15, Issue:2 | Effects of positional and geometrical isomerism on the biological activity of some novel oxazolidinones. |
| AID297960 | Antibacterial activity against Streptococcus pneumoniae 548 infected mouse lung infection model assessed as reduction in bacterial count at 80 mg/kg/day, po relative to control | 2007 | Journal of medicinal chemistry, Oct-04, Volume: 50, Issue:20 | Novel substituted (pyridin-3-yl)phenyloxazolidinones: antibacterial agents with reduced activity against monoamine oxidase A and increased solubility. |
| AID284970 | Antimicrobial activity against Corynebacterium jeikeium at 1 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID511432 | Antimicrobial activity against Clostridium perfringens LFM1 assessed as resistance breakpoint by DIN-standardized microdilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Resistance to linezolid in a porcine Clostridium perfringens strain carrying a mutation in the rplD gene encoding the ribosomal protein L4. |
| AID541092 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Linezolid alone or combined with rifampin against methicillin-resistant Staphylococcus aureus in experimental foreign-body infection. |
| AID278918 | Antibacterial activity against linezolid-resistant Enterococcus faecium | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | In vitro antibacterial activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. |
| AID1723498 | Antibacterial activity against Enterococcus faecium NR-31971 incubated for 18 to 20 hrs under aerobic condition by CLSI protocol based broth microdilution assay | |||
| AID285005 | Antimicrobial activity against Enterococcus gallinarum at 2 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID519095 | Antimicrobial activity against Staphylococcus aureus NRS121 clinical isolate harboring G2576U mutation in 23S rRNA by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Linezolid and tiamulin cross-resistance in Staphylococcus aureus mediated by point mutations in the peptidyl transferase center. |
| AID564826 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus assessed as susceptible isolates after 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID1501363 | Bactericidal activity against Staphylococcus aureus RN4220 NRS107 incubated for 20 hrs followed by replating on tryptic soy agar plates and further incubated for 18 hrs by broth microdilution assay | 2017 | European journal of medicinal chemistry, Oct-20, Volume: 139 | Arylthiazole antibiotics targeting intracellular methicillin-resistant Staphylococcus aureus (MRSA) that interfere with bacterial cell wall synthesis. |
| AID573153 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID523837 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus by CLSI method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative activities of TR-700 (torezolid) against staphylococcal blood isolates collected in Spain. |
| AID1689206 | Antibacterial activity against Escherichia coli JW55031 harboring tolC mutation assessed as reduction in bacterial growth by CLSI based broth microdilution method | 2020 | European journal of medicinal chemistry, Mar-01, Volume: 189 | Oxadiazolylthiazoles as novel and selective antifungal agents. |
| AID278875 | Increase in lactate production in primary human osteoblasts at 6 ug/ml by ELISA | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Influence on mitochondria and cytotoxicity of different antibiotics administered in high concentrations on primary human osteoblasts and cell lines. |
| AID1596559 | Antibacterial activity against Methicillin resistant Streptococcus pneumoniae ATCC 700677 assessed as reduction in bacterial cell growth incubated for 18 to 20 hrs by broth microdilution method | 2019 | European journal of medicinal chemistry, Aug-01, Volume: 175 | Lipophilic efficient phenylthiazoles with potent undecaprenyl pyrophosphatase inhibitory activity. |
| AID1710598 | Bactericidal activity against methicillin-resistant Staphylococcus aureus ATCC 33592 assessed as reduction in bacterial growth incubated for 18 hrs by CLSI method | 2020 | RSC medicinal chemistry, Jan-01, Volume: 11, Issue:1 | Potent trifluoromethoxy, trifluoromethylsulfonyl, trifluoromethylthio and pentafluorosulfanyl containing (1,3,4-oxadiazol-2-yl)benzamides against drug-resistant Gram-positive bacteria. |
| AID734706 | Antibacterial activity against Staphylococcus aureus MTCC 96 after 24 hrs by agar dilution method | 2013 | European journal of medicinal chemistry, Apr, Volume: 62 | Synthesis, biological evaluation of new oxazolidino-sulfonamides as potential antimicrobial agents. |
| AID1680005 | Induction of cytoplasmic membrane depolarization in Staphylococcus aureus ATCC 29213 at 20 ug/ml measured for 12 mins by DiSC35 dye-based fluorescence assay | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Synthesis and antibacterial bioactivities of cationic deacetyl linezolid amphiphiles. |
| AID1770361 | Ratio of MBC to MIC against erythromycin-susceptible Staphylococcus aureus ATCC 25923 | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Modification of 5-methylphenanthridium from benzothiazoles to indoles as potent FtsZ inhibitors: Broadening the antibacterial spectrum toward vancomycin-resistant enterococci. |
| AID1852664 | Antibacterial activity against multidrug resistant Klebsiella aerogenes ATCC13048 assessed as inhibition of bacterial growth incubated for 24 hrs in M9-MOPS medium by twofold serial dilution method | |||
| AID134120 | Protective dose of subcutaneously administered compound against intraperitoneally-induced septicaemia model (Staphylococcus aureus GO3) in murine | 2000 | Bioorganic & medicinal chemistry letters, Aug-07, Volume: 10, Issue:15 | Improved antibacterial activities of coumarin antibiotics bearing 5',5'-dialkylnoviose: biological activity of RU79115. |
| AID206452 | In vitro antibacterial activity against oxazolidinone Linezolid resistant Staphylococcus aureus (Sau3LZD) was determined | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | Structure-activity relationship in the oxazolidinone-quinolone hybrid series: influence of the central spacer on the antibacterial activity and the mode of action. |
| AID326279 | Antibacterial activity against methicillin-resistant Staphylococcus aureus at 4 hrs daily exposure for 5 day | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Comparative activities of daptomycin, linezolid, and tigecycline against catheter-related methicillin-resistant Staphylococcus bacteremic isolates embedded in biofilm. |
| AID287257 | Antimicrobial activity against Staphylococcus aureus ATCC 25922 by agar dilution method | 2007 | European journal of medicinal chemistry, Feb, Volume: 42, Issue:2 | Structure-antibacterial activity of arylcarbonyl- and arylsulfonyl-piperazine 5-triazolylmethyl oxazolidinones. |
| AID1390465 | Antibacterial activity against methicillin-resistant Staphylococcus aureus 1201984 | 2018 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 28, Issue:7 | Design, synthesis and biological evaluation of spiropyrimidinetriones oxazolidinone derivatives as antibacterial agents. |
| AID1677809 | Antibacterial activity against Bacillus subtilis ATCC9372 incubated for 24 hrs by CLSI-based broth microdilution method | 2020 | Bioorganic & medicinal chemistry, 11-01, Volume: 28, Issue:21 | Design, synthesis of novel 4,5-dihydroisoxazole-containing benzamide derivatives as highly potent FtsZ inhibitors capable of killing a variety of MDR Staphylococcus aureus. |
| AID560521 | Antimicrobial activity against SCCmec type III vancomycin-intermediate Staphylococcus aureus isolate xa07029 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID572283 | Antimicrobial activity against methicillin susceptible Staphylococcus aureus ATCC 49951 infected in sc dosed NMRI mouse treated 1 and 5 hrs post infection | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vivo characterization of the peptide deformylase inhibitor LBM415 in murine infection models. |
| AID206817 | In vitro antibacterial activity against Staphylococcus pyogenes C6003 | 2003 | Bioorganic & medicinal chemistry letters, Jul-07, Volume: 13, Issue:13 | Synthesis and in vitro activity of new methylenepiperidinyl and methylenepyrrolidinyl oxazolidinone antibacterial agents. |
| AID1877889 | Antibacterial activity against Enterococcus faecalis DSM-20478 assessed as bacterial growth inhibition | 2022 | Bioorganic & medicinal chemistry letters, 03-01, Volume: 59 | Novel 2,4-disubstituted quinazoline analogs as antibacterial agents with improved cytotoxicity profile: Modification of the benzenoid part. |
| AID532791 | Antibacterial activity against vancomycin-intermediate Staphylococcus aureus LIM2 after 24 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Improved antimicrobial activity of linezolid against vancomycin-intermediate Staphylococcus aureus. |
| AID133992 | Protective dose of orally administered compound against intraperitoneally-induced septicaemia model ( vancomycin resistant Enterococci faecium D3HM4 strain) in murine | 2000 | Bioorganic & medicinal chemistry letters, Aug-07, Volume: 10, Issue:15 | Improved antibacterial activities of coumarin antibiotics bearing 5',5'-dialkylnoviose: biological activity of RU79115. |
| AID1680067 | Antibacterial activity against Escherichia coli ATCC 25922 assessed as reduction in bacterial growth incubated 16 to 20 hrs by CLSI-based broth microdilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Synthesis and antibacterial bioactivities of cationic deacetyl linezolid amphiphiles. |
| AID555302 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 by broth macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Antistaphylococcal activity of dihydrophthalazine antifolates, a family of novel antibacterial drugs. |
| AID263960 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus DRCC 035 | 2006 | Bioorganic & medicinal chemistry letters, May-01, Volume: 16, Issue:9 | Synthesis and antibacterial activity of novel oxazolidinones bearing N-hydroxyacetamidine substituent. |
| AID285112 | Antimicrobial activity against viridans group Streptococcus oralis at <= 0.06 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID383746 | Bioavailability in Sprague-Dawley rat at 10 mg/kg, iv | 2008 | European journal of medicinal chemistry, Apr, Volume: 43, Issue:4 | Synthesis and in vitro antibacterial activities of novel oxazolidinones. |
| AID499162 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus Smith OC 4172 infected in SKH1 mouse assessed as log change in bacterial colony forming unit per gram of skin tissue at 6.2 mg/kg/day, po (Rvb = 1.6 deltalog CFU) | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vivo activity of ceftobiprole in murine skin infections due to Staphylococcus aureus and Pseudomonas aeruginosa. |
| AID304008 | Increase in bone marrow myeloid/erythroid ratio in Sprague-Dawley rat at 200 mg/kg/day, po after 14 days | 2007 | Journal of medicinal chemistry, Nov-29, Volume: 50, Issue:24 | Antibacterial oxazolidinones possessing a novel C-5 side chain. (5R)-trans-3-[3-Fluoro-4- (1-oxotetrahydrothiopyran-4-yl)phenyl]-2- oxooxazolidine-5-carboxylic acid amide (PF-00422602), a new lead compound. |
| AID1151706 | Inhibition of human recombinant MAO-A expressed in yeast after 1 hr by luciferin-based luminescence assay | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID1430399 | Antibacterial activity against methicillin-resistant Staphylococcus aureus 3710 after 24 to 48 hrs by macro-broth dilution method | 2017 | Bioorganic & medicinal chemistry letters, 03-01, Volume: 27, Issue:5 | Methylsulfonyl benzothiazoles (MSBT) derivatives: Search for new potential antimicrobial and anticancer agents. |
| AID1887586 | Synergistic antibacterial activity against Staphylococcus aureus ATCC 29213 assessed as reduction in bacterial growth incubated for 24 hrs in presence of artocarpin by checkerboard method | 2022 | Journal of natural products, 10-28, Volume: 85, Issue:10 | Developing the Natural Prenylflavone Artocarpin from |
| AID582990 | Antimicrobial activity against glycopeptide-resistant Enterococcus faecalis isolate HS08257 harboring MLST sequence type ST341 and pulsotype F expressing vanM gene cluster isolated from urine of patient by Etest | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | vanM, a new glycopeptide resistance gene cluster found in Enterococcus faecium. |
| AID528704 | Antibacterial activity against Streptococcus intermedius clinical isolate assessed as susceptibility level by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID318368 | Inhibition of fatty acid synthesis in Staphylococcus aureus in whole cell activity assay | 2007 | Proceedings of the National Academy of Sciences of the United States of America, May-01, Volume: 104, Issue:18 | Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties. |
| AID409581 | Antimicrobial activity against sStreptococcus pneumoniae after 16 to 18 hrs by agar dilution method | 2008 | European journal of medicinal chemistry, Aug, Volume: 43, Issue:8 | Synthesis and biological evaluation of new N-linked 5-triazolylmethyl oxazolidinones. |
| AID576668 | Bactericidal activity against 2 hrs peripheral compartment culture samples of Enterococcus faecalis Ef1497 in two-compartment pharmacokinetic/pharmacodynamic model assessed as effect on bacterial count at 600 mg, bid administered as 0.5 hr infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID583887 | Antibacterial activity against community-associated methicillin-resistant Staphylococcus aureus isolate 145 by broth microdilution assay | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Comparative efficacies of human simulated exposures of telavancin and vancomycin against methicillin-resistant Staphylococcus aureus with a range of vancomycin MICs in a murine pneumonia model. |
| AID370018 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus Smith infected in C3H mouse assessed as mortality at 3.12 mg/kg/day, iv administered within 15 mins of infection measured after 48 hrs by organ burden assay relative to control | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vivo efficacy of a novel oxazolidinone compound in two mouse models of infection. |
| AID560519 | Antimicrobial activity against SCCmec type III vancomycin-intermediate Staphylococcus aureus isolate zj07028 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID520226 | Antimicrobial activity against Streptococcus pneumoniae PU1071099 harboring 65WR66 deletion in ribosomal protein L4 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID1252238 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus ATCC 33591 | 2015 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 25, Issue:21 | Rapid synthesis and antimicrobial activity of novel 4-oxazolidinone heterocycles. |
| AID1519265 | Antibacterial activity agianst vancomycin-resistant Enterococcus faecium clinical isolates | 2019 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 29, Issue:23 | Synthesis and antibacterial evaluation of novel oxazolidinone derivatives containing a piperidinyl moiety. |
| AID523807 | Antimicrobial activity against oxacillin-susceptible Staphylococcus aureus assessed as inhibition of microbial growth at 2 ug/ml by CLSI method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative activities of TR-700 (torezolid) against staphylococcal blood isolates collected in Spain. |
| AID558472 | Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus 1287 measured on day 5 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID560800 | Elimination half life in human adults with pulmonary tuberculosis at 600 mg administered daily for 7 days | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Population pharmacokinetics of linezolid in adults with pulmonary tuberculosis. |
| AID1904920 | Antibacterial activity against Vancomycin-resistant Staphylococcus aureus 9 incubated for 18 to 20 hrs by broth microdilution method | 2022 | European journal of medicinal chemistry, Apr-15, Volume: 234 | Exploring the structure-activity relationships of diphenylurea as an antibacterial scaffold active against methicillin- and vancomycin-resistant Staphylococcus aureus. |
| AID528977 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus isolated from ICU patient blood assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID1653081 | Antibacterial activity against Bacillus pumilus | 2019 | European journal of medicinal chemistry, Feb-15, Volume: 164 | Isatin derivatives and their anti-bacterial activities. |
| AID1692905 | Antibacterial activity against hospital acquired methicillin-sensitive Staphylococcus aureus clinical isolates | 2021 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 32 | Design, synthesis and antibacterial evaluation of novel oxazolidinone derivatives nitrogen-containing fused heterocyclic moiety. |
| AID1151778 | Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate 0605 in mouse thigh infection model assessed as reduction of log10 CFU per thigh at 20 mg/kg, po | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID524724 | Antibacterial activity against linezolid-resistant Enterococcus faecium 03B1074 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro antibacterial activity of CE-156811, a novel analog derived from hygromycin A. |
| AID561729 | Antibacterial activity against Enterococcus faecalis assessed as susceptible isolates by CLSI broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Potency and bactericidal activity of iclaprim against recent clinical gram-positive isolates. |
| AID283169 | Antimicrobial susceptibility of Staphylococcus lugdunensis IDRL5258 biofilms after 24 hrs assessed as bacterial regrowth | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | In vitro effects of antimicrobial agents on planktonic and biofilm forms of Staphylococcus lugdunensis clinical isolates. |
| AID1680066 | Antibacterial activity against Salmonella enterica ATCC 8387 assessed as reduction in bacterial growth incubated for 16 to 20 hrs by CLSI-based broth microdilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Synthesis and antibacterial bioactivities of cationic deacetyl linezolid amphiphiles. |
| AID1415067 | Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate 3 after 16 hrs by agar dilution method | 2018 | Journal of medicinal chemistry, 12-27, Volume: 61, Issue:24 | Semisynthesis of Platensimycin Derivatives with Antibiotic Activities in Mice via Suzuki-Miyaura Cross-Coupling Reactions. |
| AID763951 | Antibacterial activity against Moraxella catarrhalis clinical isolate 138 after 18 hrs by NCCLS agar dilution method | 2013 | European journal of medicinal chemistry, Aug, Volume: 66 | Synthesis and antibacterial activities of N-substituted-glycinyl 1H-1,2,3-triazolyl oxazolidinones. |
| AID391589 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus Smith by agar dilution method | 2008 | Journal of medicinal chemistry, Oct-23, Volume: 51, Issue:20 | Synthesis and structure-activity relationship studies of highly potent novel oxazolidinone antibacterials. |
| AID1161137 | Antimicrobial activity against Staphylococcus aureus after 24 hrs by broth microdilution method | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | Synthesis, antibacterial activity, and biological evaluation of formyl hydroxyamino derivatives as novel potent peptide deformylase inhibitors against drug-resistant bacteria. |
| AID444057 | Fraction escaping hepatic elimination in human | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3 | Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. |
| AID285074 | Antimicrobial activity against viridans group Streptococcus anginosus at 0.5 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID285126 | Antimicrobial activity against viridans group Streptococcus salivarius at 0.25 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID576406 | Mean residence time in two-compartment pharmacokinetic/pharmacodynamic model at 600 mg, bid administered as 0.5 hrs infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID1374167 | Antibacterial activity against Staphylococcus aureus ATCC 29213 incubated at 37 degC for 20 hrs by agar dilution method | 2018 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4 | Design, synthesis and antibacterial evaluation of honokiol derivatives. |
| AID617587 | Antibacterial activity against Staphylococcus epidermidis ATCC 12228 by CLSI method | 2011 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 21, Issue:18 | Synthesis and in vitro activity of novel 1,2,4-triazolo[4,3-a]pyrimidine oxazolidinone antibacterial agents. Part II. |
| AID1308241 | Bacteriostatic activity against methicillin-resistant Staphylococcus aureus NRS70 | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10 | Structure-Activity Relationship for the 4(3H)-Quinazolinone Antibacterials. |
| AID576432 | Bactericidal activity against 12.5 hrs peripheral compartment culture samples of Staphylococcus aureus RN4220 in two-compartment pharmacokinetic/pharmacodynamic model assessed as effect on bacterial count at 600 mg, bid administered as 0.5 hr infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID370029 | Antibacterial activity against 3.6 x 10'8 CFU methicillin-resistant Staphylococcus aureus COL by dilution susceptibility test | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vivo efficacy of a novel oxazolidinone compound in two mouse models of infection. |
| AID533009 | Antibacterial activity against vancomycin-intermediate Staphylococcus aureus 28160 phenotypic revertant after 24 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Improved antimicrobial activity of linezolid against vancomycin-intermediate Staphylococcus aureus. |
| AID368286 | Half life in rabbit plasma at 58 mg/kg after 12 hrs | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vivo efficacy of ceftaroline (PPI-0903), a new broad-spectrum cephalosporin, compared with linezolid and vancomycin against methicillin-resistant and vancomycin-intermediate Staphylococcus aureus in a rabbit endocarditis model. |
| AID1374174 | Antibacterial activity against Staphylococcus epidermidis ATCC 12228 incubated at 37 degC for 20 hrs by agar dilution method | 2018 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4 | Design, synthesis and antibacterial evaluation of honokiol derivatives. |
| AID260056 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus ATCC 29213 | 2006 | Bioorganic & medicinal chemistry letters, Feb, Volume: 16, Issue:3 | New potential antibacterials: a synthetic route to N-aryloxazolidinone/3-aryltetrahydroisoquinoline hybrids. |
| AID390328 | Antimicrobial activity against vancomycin-resistant Enterococcus faecium 700221 clinical isolate | 2008 | Journal of natural products, Dec, Volume: 71, Issue:12 | Citreamicins with potent gram-positive activity. |
| AID1852676 | Antibacterial activity against efflux pump lacking Acinetobacter baumannii assessed as inhibition of bacterial growth | |||
| AID410110 | Antimicrobial activity against vanB+ expressing Enterococcus faecalis 1069 by NCCLS method | 2008 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 18, Issue:23 | Design at the atomic level: design of biaryloxazolidinones as potent orally active antibiotics. |
| AID1547739 | Drug level in mouse thigh infected with linezolid-resistant Staphylococcus aureus NRS119 at 40 mg/kg, po administered 1 hrs post infection and measured for 48 hrs | 2020 | ACS medicinal chemistry letters, Mar-12, Volume: 11, Issue:3 | Structure-Activity Relationship for the Oxadiazole Class of Antibacterials. |
| AID1374184 | Bactericidal activity against Staphylococcus aureus ATCC 25923 at 4 times MIC incubated for 24 hrs by time kill curve assay | 2018 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4 | Design, synthesis and antibacterial evaluation of honokiol derivatives. |
| AID1547718 | Antibacterial activity against vancomycin-susceptible Enterococcus faecium 119-39A clinical isolate by broth microdilution method | 2020 | ACS medicinal chemistry letters, Mar-12, Volume: 11, Issue:3 | Structure-Activity Relationship for the Oxadiazole Class of Antibacterials. |
| AID576871 | Bactericidal activity against 24 hrs peripheral compartment culture samples of Enterococcus faecalis Ef1497 MutM3 in two-compartment pharmacokinetic/pharmacodynamic model assessed as effect on bacterial count at 200 mg, bid administered as 0.5 hr infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID1197128 | Antibacterial activity against vancomycin-susceptible Enterococcus faecalis 201 clinical isolate after 16 to 20 hrs by broth microdilution method | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3 | Structure-activity relationship for the oxadiazole class of antibiotics. |
| AID576890 | Ratio of Cmax to MIC for 0.5 hrs peripheral compartment culture samples of Enterococcus faecalis Ef1497 in two-compartment pharmacokinetic/pharmacodynamic model at 600 mg, bid administered as 0.5 hr infusion for 2 days | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID308729 | Antibacterial activity against Enterococcus faecalis MG2 EF1 by micro-broth method | 2007 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 17, Issue:16 | Synthesis and SAR of novel conformationally-restricted oxazolidinones possessing gram-positive and fastidious gram-negative antibacterial activity. Part 1: Substituted pyrazoles. |
| AID573891 | fAUC (0 to 24 hrs) in CF-1 mouse at 10 mg/kg, sc | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | In vivo activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. |
| AID285348 | Antibacterial activity against community acquired methicillin-resistant Staphylococcus aureus HT20020488 in CCY medium | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Effect of antibiotics on Staphylococcus aureus producing Panton-Valentine leukocidin. |
| AID528714 | Antibacterial activity against methicillin resistant coagulase-negative Staphylococcus capitis clinical isolate assessed as susceptibility level by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID1781724 | Antibacterial activity against Staphylococcus aureus ATCC 29213 assessed as bacterial growth inhibition incubated for 16 to 18 hrs by broth microdilution method | |||
| AID519089 | Antimicrobial activity against Staphylococcus aureus KM166-167 harboring Ser158Leu mutation in rplC gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Linezolid and tiamulin cross-resistance in Staphylococcus aureus mediated by point mutations in the peptidyl transferase center. |
| AID1578430 | Antimicrobial activity against vancomycin-resistant Enterococcus faecium ATCC 700221 by broth liquid microdilution method | 2020 | European journal of medicinal chemistry, Jan-01, Volume: 185 | Modifying the lipophilic part of phenylthiazole antibiotics to control their drug-likeness. |
| AID308916 | Antibacterial activity against Staphylococcus aureus ATCC 33591 by broth microdilution method | 2007 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 17, Issue:18 | Synthesis and in vitro antibacterial activity of novel methylamino piperidinyl oxazolidinones. |
| AID560501 | Antimicrobial activity against SCCmec type III vancomycin-intermediate Staphylococcus aureus isolate gz06040 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID1649283 | Antibacterial activity against Vancomycin-resistant Staphylococcus aureus HIP11983 assessed as inhibition of bacterial growth incubated for 20 hrs by microdilution broth method | |||
| AID323814 | Reduction in bioluminescent methicillin-resistant Staphylococcus aureus Xen1 in neutropenic CD1 mouse with peritonitis at 100 mg/kg, po after 5 hrs relative to control | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Rapid bactericidal activity of daptomycin against methicillin-resistant and methicillin-susceptible Staphylococcus aureus peritonitis in mice as measured with bioluminescent bacteria. |
| AID374005 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus 540 after 36 passages with Linezolid measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID572284 | Antimicrobial activity against methicillin susceptible Staphylococcus aureus ATCC 13709 infected in po dosed NMRI mouse treated 1 and 5 hrs post infection | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vivo characterization of the peptide deformylase inhibitor LBM415 in murine infection models. |
| AID583876 | Antibacterial activity against laboratory-derived Staphylococcus aureus isolate 29213-2 harboring ribosomal protein L3 Gly155Arg/Met169Leu mutant by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Elevated linezolid resistance in clinical cfr-positive Staphylococcus aureus isolates is associated with co-occurring mutations in ribosomal protein L3. |
| AID520013 | Antimicrobial activity against Staphylococcus aureus A8761 | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID303915 | Antibacterial activity against Enterococcus faecalis ATCC 29212 after 24 hrs by agar dilution method | 2007 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 17, Issue:24 | Synthesis and antibacterial activity of potent heterocyclic oxazolidinones and the identification of RBx 8700. |
| AID552861 | Antibacterial activity against Streptococcus pneumoniae infected in po dosed in vivo lung model administered bid for 3 day | 2011 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1 | The discovery and structure-activity relationships leading to CE-156811, a difluorophenyl cyclopropyl fluoroether: a novel potent antibacterial analog derived from hygromycin A. |
| AID1375989 | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv measured after 2 weeks | 2016 | MedChemComm, Nov-01, Volume: 7, Issue:11 | SAR and identification of 2-(quinolin-4-yloxy)acetamides as |
| AID352924 | Antibacterial activity against Enterococcus faecium C803 after 18 to 20 hrs by agar dilution method | 2009 | Bioorganic & medicinal chemistry letters, May-01, Volume: 19, Issue:9 | Synthesis and antibacterial activities of novel oxazolidinones having spiro[2,4]heptane moieties. |
| AID583707 | Antibacterial activity against clinical-derived Staphylococcus aureus isolate 51312 harboring ribosomal protein L3 deltaMet169-Gly174 mutant by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Elevated linezolid resistance in clinical cfr-positive Staphylococcus aureus isolates is associated with co-occurring mutations in ribosomal protein L3. |
| AID1180578 | Antimicrobial activity against Staphylococcus aureus ARC2398 by broth microdilution/CLSI method | 2014 | Journal of medicinal chemistry, Jul-24, Volume: 57, Issue:14 | Optimization of pyrrolamide topoisomerase II inhibitors toward identification of an antibacterial clinical candidate (AZD5099). |
| AID533938 | Antimicrobial activity against linezolid-resistant Staphylococcus aureus 425 harboring G2447U in peptidyl transferase centre by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains. |
| AID319985 | Antimicrobial activity against vancomycin-resistant Enterococcus faecalis NCTC-12201 | 2008 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 18, Issue:2 | Synthesis, SAR, and antibacterial activity of novel oxazolidinone analogues possessing urea functionality. |
| AID523795 | Antimicrobial activity against oxacillin-resistant coagulase-negative Staphylococcus aureus by CLSI method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative activities of TR-700 (torezolid) against staphylococcal blood isolates collected in Spain. |
| AID542694 | fT>MIC in Bacillus anthracis infected in vitro hollow fiber PK/PD model at simulated dose of 700 mg administered every 24 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID206148 | In vitro antibacterial activity against S. a. 213 (Staphylococcus. aureus ATCC 49951) | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | Influence of ethylene-oxy spacer group on the activity of linezolid: synthesis of potent antibacterials possessing a thiocarbonyl group. |
| AID576641 | Bactericidal activity against 2 hrs peripheral compartment culture samples of Staphylococcus aureus RN4220 MutS2 in two-compartment pharmacokinetic/pharmacodynamic model assessed as effect on bacterial count at 600 mg, bid administered as 0.5 hr infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID625282 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cirrhosis | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID283626 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus Ho 4536-0367 with heterozygous 23S rRNA G2576U mutation | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | In vitro activity of the oxazolidinone RWJ-416457 against linezolid-resistant and -susceptible staphylococci and enterococci. |
| AID574082 | Ratio of fAUC (24 hrs) for community-associated methicillin-resistant Staphylococcus aureus OC8525 infected sc dosed mouse to MIC for community-associated methicillin-resistant Staphylococcus aureus OC8525 | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | In vivo activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. |
| AID520774 | Toxicity in methicillin-resistant Staphylococcus aureus-infected New Zealand rabbit osteomyelitis model assessed as body weight at 60 mg/kg, po administered every 8 hrs for 4 days measured on week 8 postinfection (Rvb = 2.43 +/- 0.15 kg) | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Efficacies of ceftobiprole medocaril and comparators in a rabbit model of osteomyelitis due to methicillin-resistant Staphylococcus aureus. |
| AID573120 | Antibacterial activity against coagulase-negative and oxacillin-susceptible Staphylococcus aureus assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID695446 | Antibacterial activity against fluoroquinolone resistant Staphylococcus aureus 5-FQR4M BSA678 expressing GyrA Ser84Leu and Ser85Pro mutant and GrlA Ser80Phe and Glu84Lys mutant | 2011 | Journal of medicinal chemistry, May-12, Volume: 54, Issue:9 | Selenophene-containing inhibitors of type IIA bacterial topoisomerases. |
| AID390335 | Antimicrobial activity against Escherichia coli 25922 QC | 2008 | Journal of natural products, Dec, Volume: 71, Issue:12 | Citreamicins with potent gram-positive activity. |
| AID532797 | Antibacterial activity against vancomycin-intermediate Staphylococcus aureus NJ after 24 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Improved antimicrobial activity of linezolid against vancomycin-intermediate Staphylococcus aureus. |
| AID373818 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus 540 after 36 passages by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID373994 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus 547 after 21 passages with daptomycin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID1852669 | Antibacterial activity against multidrug resistant Pseudomonas aeruginosa BAA 2109 assessed as inhibition of bacterial growth incubated for 24 hrs in MHI medium by twofold serial dilution method | |||
| AID1361099 | Bacteriostatic activity against methicillin-resistant Staphylococcus aureus USA300 NRS384 clinical isolate after 20 hrs by broth microdilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | N-(1,3,4-oxadiazol-2-yl)benzamide analogs, bacteriostatic agents against methicillin- and vancomycin-resistant bacteria. |
| AID520488 | Cmin in New Zealand rabbit at 20 mg/kg, sc administered every 6 hrs for 4 days measured after 1 hr post first dose by RP-HPLC/MS/MS | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Efficacies of ceftobiprole medocaril and comparators in a rabbit model of osteomyelitis due to methicillin-resistant Staphylococcus aureus. |
| AID1553375 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus ATCC 25923 after 16 hrs by broth microdilution method | 2019 | Bioorganic & medicinal chemistry letters, 09-15, Volume: 29, Issue:18 | Incorporation of a chiral gem-disubstituted nitrogen heterocycle yields an oxazolidinone antibiotic with reduced mitochondrial toxicity. |
| AID1180576 | Antimicrobial activity against 2 times drug resistance selected Staphylococcus aureus ARC2381-2F by broth microdilution/CLSI method | 2014 | Journal of medicinal chemistry, Jul-24, Volume: 57, Issue:14 | Optimization of pyrrolamide topoisomerase II inhibitors toward identification of an antibacterial clinical candidate (AZD5099). |
| AID1852680 | Antibacterial activity against wild type Escherichia coli assessed as inhibition of bacterial growth | |||
| AID373836 | Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus 504 after 22 passages with Linezolid measured after 10 times antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID763955 | Antibacterial activity against Moraxella catarrhalis clinical isolate 1 after 18 hrs by NCCLS agar dilution method | 2013 | European journal of medicinal chemistry, Aug, Volume: 66 | Synthesis and antibacterial activities of N-substituted-glycinyl 1H-1,2,3-triazolyl oxazolidinones. |
| AID577141 | Apparent volume of distribution in two-compartment pharmacokinetic/pharmacodynamic model at 800 mg, bid administered as 0.5 hr infusion over 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID542678 | fCmax in Bacillus anthracis infected in vitro hollow fiber PK/PD model at simulated dose of 700 mg administered every 24 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID528850 | Antimicrobial activity against methicillin-susceptible Staphylococcus epidermidis isolated from ICU patient wound assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID458457 | Antimicrobial activity against Pseudomonas aeruginosa K799/61 mutant at 2 mM after overnight incubation by agar diffusion method | 2010 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 20, Issue:3 | Syntheses and antibacterial activity studies of new oxazolidinones from nitroso Diels-Alder chemistry. |
| AID289863 | Antibacterial activity against Staphylococcus aureus ATCC 33591 | 2007 | European journal of medicinal chemistry, Apr, Volume: 42, Issue:4 | Synthesis, SAR and antibacterial studies on novel chalcone oxazolidinone hybrids. |
| AID345133 | Antimicrobial activity against Haemophilus influenzae 895 (AcrB-KO) by NCCLS method | 2008 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 18, Issue:23 | Design at the atomic level: generation of novel hybrid biaryloxazolidinones as promising new antibiotics. |
| AID542914 | Antimicrobial activity against Bacillus anthracis infected in in vitro hollow fiber PK/PD model assessed as cell killing followed by emergence of resistance between 4 to 8 days at 600 mg administered once every 24 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID576872 | Bactericidal activity against 48 hrs peripheral compartment culture samples of Enterococcus faecalis Ef1497 MutM3 in two-compartment pharmacokinetic/pharmacodynamic model assessed as effect on bacterial count at 200 mg, bid administered as 0.5 hr infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID1308235 | Antibacterial activity against methicillin-susceptible Enterococcus faecalis ATCC 29212 incubated for 16 to 20 hrs by microdilution method | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10 | Structure-Activity Relationship for the 4(3H)-Quinazolinone Antibacterials. |
| AID67387 | In vitro antibacterial activity against vancomycin-susceptible E. f. 153 (Enterococcus faecalis ATCC 29212) | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | Influence of ethylene-oxy spacer group on the activity of linezolid: synthesis of potent antibacterials possessing a thiocarbonyl group. |
| AID1056350 | Antibacterial activity against methicillin-resistant Staphylococcus aureus SR3637 clinical isolate infected in po dosed JCL/ICR systemic infection model assessed as mortality administered after 1 hr of infection measured for 7 days | 2013 | ACS medicinal chemistry letters, Nov-14, Volume: 4, Issue:11 | Potent oxazolidinone antibacterials with heteroaromatic C-ring substructure. |
| AID383569 | Antibacterial activity against linezolid-resistant Staphylococcus aureus NRS 120 with G 2576T mutation by broth microdilution technique | 2008 | European journal of medicinal chemistry, Apr, Volume: 43, Issue:4 | Synthesis and in vitro antibacterial activities of novel oxazolidinones. |
| AID745378 | Inhibition of human CYP2C9 assessed as tolbutamide hydroxylation after 20 mins by LC/MS/MS analysis | 2013 | European journal of medicinal chemistry, May, Volume: 63 | Antibacterial oxazolidinone analogues having a N-hydroxyacetyl-substituted seven-membered [1,2,5]triazepane or [1,2,5]oxadiazepane C-ring unit. |
| AID729216 | Antibacterial activity against linezolid-resistant Enterococcus faecalis after 16 hrs by NCCLS agar dilution method | 2013 | Journal of medicinal chemistry, Mar-28, Volume: 56, Issue:6 | Solubility-driven optimization of (pyridin-3-yl) benzoxazinyl-oxazolidinones leading to a promising antibacterial agent. |
| AID519081 | Antimicrobial activity against Escherichia coli KM55-68 harboring G2576U mutation in 23S rRNA by agar dilution method in presence of 16 ug/ml polymyxin B nonapeptide | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Linezolid and tiamulin cross-resistance in Staphylococcus aureus mediated by point mutations in the peptidyl transferase center. |
| AID562629 | Antimicrobial activity against Group C Streptococcus assessed as susceptible isolates by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | In vitro activities of three new dihydrofolate reductase inhibitors against clinical isolates of gram-positive bacteria. |
| AID285071 | Antimicrobial activity against viridans group Streptococcus anginosus at <= 0.06 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID535020 | Antimicrobial activity against vancomycin intermediate Staphylococcus aureus NRS-17 expressing SCCmec type 2 element by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | In vitro activity of ceftaroline against community-associated methicillin-resistant, vancomycin-intermediate, vancomycin-resistant, and daptomycin-nonsusceptible Staphylococcus aureus isolates. |
| AID571765 | Antimicrobial activity against Escherichia coli K-12 3-AG300 harboring AcrB-615-628MexB mutant gene | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Site-directed mutagenesis reveals amino acid residues in the Escherichia coli RND efflux pump AcrB that confer macrolide resistance. |
| AID593964 | Antibacterial activity against Escherichia coli ATCC 25922 | 2011 | Bioorganic & medicinal chemistry letters, May-15, Volume: 21, Issue:10 | Synthesis and in vitro activity of novel 1,2,4-triazolo[4,3-a]pyrimidine oxazolidinone antibacterial agents. |
| AID13380 | Oral bioavailability of compound (25 mg/kg) after po administration was determined in Sprague-Dawley rat | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | The effect of remote chirality on the antibacterial activity of indolinyl, tetrahydroquinolyl and dihydrobenzoxazinyl oxazolidinones. |
| AID1414197 | Bactericidal activity against clinical isolate of penicillin-resistant Staphylococcus aureus incubated for 24 hrs followed by plating onto tryptic soy agar plates and further incubated for 24 hrs by broth microdilution based CLSI method | 2018 | European journal of medicinal chemistry, Nov-05, Volume: 159 | Design, synthesis and structure-based optimization of novel isoxazole-containing benzamide derivatives as FtsZ modulators. |
| AID541076 | Cmin in cage fluid of Albino guiena pig at 50 mg/kg, ip after 12 hrs | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Linezolid alone or combined with rifampin against methicillin-resistant Staphylococcus aureus in experimental foreign-body infection. |
| AID1435924 | Antibacterial activity against methicillin/ciprofloxacin/clindamycin-resistant Staphylococcus aureus USA100 NRS382 clinical isolate after 18 to 20 hrs by broth microdilution method | 2017 | European journal of medicinal chemistry, Jan-27, Volume: 126 | Phenylthiazole antibiotics: A metabolism-guided approach to overcome short duration of action. |
| AID373803 | Antimicrobial activity against vancomycin-resistant Staphylococcus aureus 509 Michigan after 28 passages by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID285114 | Antimicrobial activity against viridans group Streptococcus oralis at 0.25 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID585173 | Antibacterial activity against Mycobacterium smegmatis harboring 23S rRNA C2055A, A2572U mutant after 24 generation times | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Mutations in 23S rRNA at the peptidyl transferase center and their relationship to linezolid binding and cross-resistance. |
| AID562591 | Antimicrobial activity against Enterococcus faecium clinical isolates assessed as resistant isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID575082 | Antimicrobial activity against multiple drug resistant Streptococcus pneumoniae serotype 19A assessed as percent susceptible isolates by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID1873912 | Antibacterial activity against Staphylococcus chromogenes incubated for 16 to 20 hrs by broth microdilution method | 2022 | European journal of medicinal chemistry, Aug-05, Volume: 238 | Design, synthesis and activity against drug-resistant bacteria evaluation of C-20, C-23 modified 5-O-mycaminosyltylonolide derivatives. |
| AID775545 | Antibacterial activity against Streptococcus pneumoniae SR26207 clinical isolate assessed as growth inhibition by broth microdilution method | 2013 | European journal of medicinal chemistry, Nov, Volume: 69 | Synthesis and in vitro/in vivo antibacterial activity of oxazolidinones having thiocarbamate at C-5 on the A-ring and an amide- or urea-substituted [1,2,5]triazepane or [1,2,5]oxadiazepane as the C-ring. |
| AID1504619 | Antibacterial activity against methicillin-resistant Staphylococcus aureus 1201984 by microbroth dilution method | 2017 | ACS medicinal chemistry letters, Nov-09, Volume: 8, Issue:11 | Design, Synthesis, and Antibacterial Evaluation of Oxazolidinones with Fused Heterocyclic C-Ring Substructure. |
| AID458455 | Antimicrobial activity against vancomycin-resistant Enterococcus faecalis 1528 at 2 mM after overnight incubation by agar diffusion method | 2010 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 20, Issue:3 | Syntheses and antibacterial activity studies of new oxazolidinones from nitroso Diels-Alder chemistry. |
| AID1151740 | Antibacterial activity against Staphylococcus aureus measured after 2 serial passages | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID730383 | Antibacterial activity against Staphylococcus aureus ATCC 29213 assessed as growth inhibition | 2013 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 23, Issue:6 | Novel 3-O-carbamoyl erythromycin A derivatives (carbamolides) with activity against resistant staphylococcal and streptococcal isolates. |
| AID1584843 | Antibacterial activity against hospital-acquired methicillin/ciprofloxacin/moxifloxacin resistant Staphylococcus aureus SA 481 after 18 to 24 hrs by microdilution assay | 2018 | European journal of medicinal chemistry, Nov-05, Volume: 159 | 1-(2-Hydroxybenzoyl)-thiosemicarbazides are promising antimicrobial agents targeting d-alanine-d-alanine ligase in bacterio. |
| AID1350032 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus isolate 3 incubated overnight by agar dilution method | 2018 | Journal of natural products, 02-23, Volume: 81, Issue:2 | Biomimetic Stereoselective Sulfa-Michael Addition Leads to Platensimycin and Platencin Sulfur Analogues against Methicillin-Resistant Staphylococcus aureus. |
| AID207795 | Compound was evaluated for minimum inhibitory concentration against Staphylococcus aureus 9721 strain | 2002 | Bioorganic & medicinal chemistry letters, Mar-25, Volume: 12, Issue:6 | Synthesis and antibacterial activity of linezolid analogues. |
| AID541082 | Cmax in cage fluid of Albino guiena pig at 75 mg/kg, ip after 3 hrs | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Linezolid alone or combined with rifampin against methicillin-resistant Staphylococcus aureus in experimental foreign-body infection. |
| AID522898 | Antibacterial activity against vancomycin-intermediate Staphylococcus aureus isolate 1015 after 24 hrs by modified broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Antistaphylococcal activity of ACHN-490 tested alone and in combination with other agents by time-kill assay. |
| AID410117 | Antimicrobial activity against Haemophilus influenzae by NCCLS method | 2008 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 18, Issue:23 | Design at the atomic level: design of biaryloxazolidinones as potent orally active antibiotics. |
| AID532022 | Antimicrobial activity against Mycobacterium ulcerans 1059 harboring pTY60K containing pMH94 carrying the luxAB gene under the hsp60 promoter after 14 days determined according to CFU count by bioluminescence method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Rapid assessment of antibacterial activity against Mycobacterium ulcerans by using recombinant luminescent strains. |
| AID1474205 | Antibacterial activity against Enterococcus faecalis clinical isolates after 18 to 22 hrs by broth microdilution method | 2017 | Journal of medicinal chemistry, 03-23, Volume: 60, Issue:6 | Phenylthiazole Antibacterial Agents Targeting Cell Wall Synthesis Exhibit Potent Activity in Vitro and in Vivo against Vancomycin-Resistant Enterococci. |
| AID425652 | Total body clearance in human | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15 | Physicochemical determinants of human renal clearance. |
| AID1594372 | Antibacterial activity against Enterobacter cloacae BAA1134 after 18 to 24 hrs in presence of colistin by broth microdilution assay | 2019 | Bioorganic & medicinal chemistry, 05-01, Volume: 27, Issue:9 | Second-generation aryl isonitrile compounds targeting multidrug-resistant Staphylococcus aureus. |
| AID520016 | Antimicrobial activity against Staphylococcus epidermidis A8934 | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID576861 | Bactericidal activity against 14 hrs peripheral compartment culture samples of Enterococcus faecalis Ef1497 in two-compartment pharmacokinetic/pharmacodynamic model assessed as effect on bacterial count at 800 mg, bid administered as 0.5 hr infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID246862 | Efficacy against mice infected with Staphylococcus aureus ATCC 25923 upon s.c. administration | 2005 | Journal of medicinal chemistry, Aug-11, Volume: 48, Issue:16 | A chiral benzoquinolizine-2-carboxylic acid arginine salt active against vancomycin-resistant Staphylococcus aureus. |
| AID532811 | Antibacterial activity against vancomycin-susceptible Staphylococcus aureus BR5-1 after 24 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Improved antimicrobial activity of linezolid against vancomycin-intermediate Staphylococcus aureus. |
| AID565080 | Antibacterial activity against hospital-acquired methicillin-resistant Staphylococcus aureus 56 by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Pharmacodynamic profile of tigecycline against methicillin-resistant Staphylococcus aureus in an experimental pneumonia model. |
| AID1472757 | In vivo anti-virulence activity against methicillin-resistant Staphylococcus aureus LRSA202 infected in BALB/c mouse model assessed as reduction in bacterial load in kidney at 0.1 mg bid for 3.5 days administered intraperitoneally 6 hrs post infection by | 2018 | Journal of medicinal chemistry, 01-11, Volume: 61, Issue:1 | Novel Terminal Bipheny-Based Diapophytoene Desaturases (CrtN) Inhibitors as Anti-MRSA/VISR/LRSA Agents with Reduced hERG Activity. |
| AID519482 | Antibacterial activity against Staphylococcus aureus T2019 with G2576T mutation in 23S rRNA genes by Etest method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Linezolid resistance in Staphylococcus aureus: gene dosage effect, stability, fitness costs, and cross-resistances. |
| AID533934 | Antimicrobial activity against linezolid-resistant Staphylococcus aureus CM/05 3067 harboring chromosomal cfr gene by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains. |
| AID206223 | In vitro antibacterial activity against Staphylococcus epidermis (S.e.2) C2235. | 1999 | Bioorganic & medicinal chemistry letters, Sep-20, Volume: 9, Issue:18 | Synthesis and in vitro activity of new oxazolidinone antibacterial agents having substituted isoxazoles. |
| AID558518 | Antimicrobial activity against vancomycin-resistant Staphylococcus aureus 509 measured on day 25 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID206650 | Antibacterial activity was determined against clinically isolated Levofloxacin-methicillin resistant Staphylococcus aureus (LVFX-r MRSA) strains (74 strains) | 2003 | Journal of medicinal chemistry, Mar-13, Volume: 46, Issue:6 | Synthesis and structure-activity relationships of 5-amino-6-fluoro-1-[(1R,2S)-2-fluorocyclopropan-1-yl]-8-methylquinolonecarboxylic acid antibacterials having fluorinated 7-[(3R)-3-(1-aminocyclopropan-1-yl)pyrrolidin-1-yl] substituents. |
| AID533977 | Antimicrobial activity against linezolid-susceptible Staphylococcus aureus NRS18 infected in THP1 cells after 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Cellular pharmacodynamics of the novel biaryloxazolidinone radezolid: studies with infected phagocytic and nonphagocytic cells, using Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Legionella pneumophila. |
| AID573860 | Antibacterial activity against Methicillin-susceptible Staphylococcus aureus ATCC 13709 after 16 to 20 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | In vivo activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. |
| AID564819 | Antimicrobial activity against methicillin-resistant coagulase-negative Staphylococcus hominis assessed as susceptible isolates after 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID535254 | Antimicrobial activity against vancomycin resistant Staphylococcus aureus VRS-2 expressing SCCmec type 2 element by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | In vitro activity of ceftaroline against community-associated methicillin-resistant, vancomycin-intermediate, vancomycin-resistant, and daptomycin-nonsusceptible Staphylococcus aureus isolates. |
| AID577101 | T>MIC in Enterococcus faecalis Ef1497 MutM3 in two-compartment pharmacokinetic/pharmacodynamic model at 600 mg, bid administered as 0.5 hr infusion for 2 days | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID583405 | Antimicrobial activity against vancomycin-resistant Staphylococcus aureus isolate MI assessed as bacterial count at 16 times MIC after 24 hrs by colony counting method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | In vitro activity of the new multivalent glycopeptide-cephalosporin antibiotic TD-1792 against vancomycin-nonsusceptible Staphylococcus isolates. |
| AID1563582 | Inhibition of FabB/FabF in methicillin-resistant Staphylococcus aureus assessed as antibacterial activity at 5 ug/disk after 18 hrs by agar disk diffusion method | 2019 | Journal of medicinal chemistry, 07-25, Volume: 62, Issue:14 | Late-Stage Functionalization of Platensimycin Leading to Multiple Analogues with Improved Antibacterial Activity in Vitro and in Vivo. |
| AID531636 | Inhibition of 50S ribosomal subunit purified from Staphylococcus aureus ATCC 29213 assessed as inhibition of translation using in vitro transcribed mRNA encoding firefly luciferase | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | R chi-01, a new family of oxazolidinones that overcome ribosome-based linezolid resistance. |
| AID69613 | Antibacterial activity against Escherichia coli (OC 2605) | 2001 | Bioorganic & medicinal chemistry letters, Jul-23, Volume: 11, Issue:14 | Novel piperidinyloxy oxazolidinone antimicrobial agents. |
| AID285149 | Antimicrobial activity against viridans group Streptococcus mitis by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID576123 | Antibacterial activity against 1 x 10'4 CFU Streptococcus pneumoniae ATCC 6305 infected in ICR mouse systemic infection model assessed as mouse protection administered orally twice after 1 and 4 hrs post infection measured after 48 hrs | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | In vitro and in vivo activities of LCB01-0371, a new oxazolidinone. |
| AID1770371 | Ratio of MBC to MIC against Vancomycin-resistant Enterococcus faecalis ATCC 51299 | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Modification of 5-methylphenanthridium from benzothiazoles to indoles as potent FtsZ inhibitors: Broadening the antibacterial spectrum toward vancomycin-resistant enterococci. |
| AID561262 | Antibacterial activity against Enterococcus faecalis assessed as susceptible isolates by CLSI M100-S17 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | AFN-1252, a FabI inhibitor, demonstrates a Staphylococcus-specific spectrum of activity. |
| AID283166 | Antimicrobial susceptibility of Staphylococcus lugdunensis IDRL5204 biofilms after 24 hrs assessed as bacterial regrowth | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | In vitro effects of antimicrobial agents on planktonic and biofilm forms of Staphylococcus lugdunensis clinical isolates. |
| AID583891 | Antibacterial activity against vancomycin-heteroresistant Staphylococcus aureus isolate 38 (Mu3) by broth microdilution assay | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Comparative efficacies of human simulated exposures of telavancin and vancomycin against methicillin-resistant Staphylococcus aureus with a range of vancomycin MICs in a murine pneumonia model. |
| AID444262 | Antibacterial activity against Enterococcus faecalis ATCC 29212 by NCCLS method | 2009 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 19, Issue:22 | Synthesis and biological activity of novel oxazolidinones. |
| AID1233137 | Antibacterial activity against patient-derived methicillin-resistant Staphylococcus aureus 7425 after 18 to 20 hrs by microbroth dilution method | 2015 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 25, Issue:13 | Thiol activated prodrugs of sulfur dioxide (SO2) as MRSA inhibitors. |
| AID245216 | Minimum inhibitory concentration against Enterococcus faecalis (strain A20688) in presence of 50% calf serum | 2004 | Bioorganic & medicinal chemistry letters, Sep-20, Volume: 14, Issue:18 | Discovery of isoxazolinone antibacterial agents. Nitrogen as a replacement for the stereogenic center found in oxazolidinone antibacterials. |
| AID1168086 | Antibacterial activity against Enterococcus infected in Wistar albino rat assessed as reduction in cell count at 25 mg/kg, iv after 1 hr relative to control | 2014 | Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21 | Synthesis and biological evaluation of novel peptide BF2 as an antibacterial agent against clinical isolates of vancomycin-resistant enterococci. |
| AID1739763 | Antitubercular activity against Mycobacterium tuberculosis H37Rv assessed as growth inhibition incubated for 3 weeks by Microplate Alamar Blue Assay | 2020 | European journal of medicinal chemistry, Sep-01, Volume: 201 | Antitubercular polyhalogenated phenothiazines and phenoselenazine with reduced binding to CNS receptors. |
| AID206055 | Inhibitory activity against methicillin-resistant Staphylococcus epidermidis (MRSE) | 1996 | Journal of medicinal chemistry, Sep-27, Volume: 39, Issue:20 | New directions in antibacterial research. |
| AID1395677 | Antibacterial activity against methicillin-resistant Staphylococcus aureus NRS384 USA300 after 18 hrs by broth microdilution assay | 2018 | European journal of medicinal chemistry, May-10, Volume: 151 | Phenylthiazoles with tert-Butyl side chain: Metabolically stable with anti-biofilm activity. |
| AID637972 | Antibacterial activity against Enterococcus faecium expressing VanA gene after overnight incubation by twofold broth dilution technique | 2012 | Bioorganic & medicinal chemistry, Jan-01, Volume: 20, Issue:1 | Efficient microwave-assisted synthesis, antibacterial activity and high fluorescence of 5 benzimidazolyl-2'-deoxyuridines. |
| AID717214 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus CCARM 3634 incubated for 24 hrs by microtiter broth dilution method | 2012 | Journal of natural products, Dec-28, Volume: 75, Issue:12 | Antibacterial butenolides from the Korean tunicate Pseudodistoma antinboja. |
| AID583708 | Antibacterial activity against laboratory-derived Staphylococcus aureus ATCC 29213 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Elevated linezolid resistance in clinical cfr-positive Staphylococcus aureus isolates is associated with co-occurring mutations in ribosomal protein L3. |
| AID1501365 | Bactericidal activity against methicillin-resistant Staphylococcus aureus USA100 NRS382 incubated for 20 hrs followed by replating on tryptic soy agar plates and further incubated for 18 hrs by broth microdilution assay | 2017 | European journal of medicinal chemistry, Oct-20, Volume: 139 | Arylthiazole antibiotics targeting intracellular methicillin-resistant Staphylococcus aureus (MRSA) that interfere with bacterial cell wall synthesis. |
| AID535010 | Antimicrobial activity against daptomycin-nonsusceptible Staphylococcus aureus assessed as susceptible isolates by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | In vitro activity of ceftaroline against community-associated methicillin-resistant, vancomycin-intermediate, vancomycin-resistant, and daptomycin-nonsusceptible Staphylococcus aureus isolates. |
| AID1151748 | Antibacterial activity against Staphylococcus aureus measured after 10 serial passages | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID548745 | Antimicrobial activity against Beta-hemolytic Streptococcus assessed as percent susceptible isolate by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Activities of dalbavancin against a worldwide collection of 81,673 gram-positive bacterial isolates. |
| AID562380 | Antimicrobial activity against Enterococcus faecium expressing VanB gene clinical isolates assessed as percent susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID268864 | Antibacterial activity against vancomycin-sensitive Enterococcus faecalis ATCC 29212 | 2006 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 16, Issue:16 | Synthesis of novel tricyclic oxazolidinones by a tandem SN2 and SNAr reaction: SAR studies on conformationally constrained analogues of Linezolid. |
| AID495880 | Antibacterial activity against methicillin-resistant Staphylococcus aureus COL infected New Zealand White rabbit aortic valve endocarditis model assessed as decrease in bacterial colony forming unit in kidney at 75 mg/kg, sc dosed every 8 hrs for 4 days ( | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Ceftobiprole is superior to vancomycin, daptomycin, and linezolid for treatment of experimental endocarditis in rabbits caused by methicillin-resistant Staphylococcus aureus. |
| AID1361121 | Bacteriostatic activity against Klebsiella pneumoniae BAA 1706 after 20 hrs by broth microdilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | N-(1,3,4-oxadiazol-2-yl)benzamide analogs, bacteriostatic agents against methicillin- and vancomycin-resistant bacteria. |
| AID70795 | In vitro minimum inhibitory concentration (MIC) against Escherichia coli UC6674 | 2003 | Journal of medicinal chemistry, Jan-16, Volume: 46, Issue:2 | Identification of phenylisoxazolines as novel and viable antibacterial agents active against Gram-positive pathogens. |
| AID1539458 | Antibacterial activity against Clostridium difficile ATCC BAA 1870 incubated for 48 hrs in anaerobic condition by CLSI-based broth microdilution assay | |||
| AID1574840 | Antibacterial activity against clinical isolates of methicillin-sensitive Staphylococcus aureus by broth liquid microdilution method | 2019 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 29, Issue:3 | Design and synthesis of biaryloxazolidinone derivatives containing a rhodanine or thiohydantoin moiety as novel antibacterial agents against Gram-positive bacteria. |
| AID560809 | Absorption half life in human adults with pulmonary tuberculosis at 600 mg administered twice daily for 7 days | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Population pharmacokinetics of linezolid in adults with pulmonary tuberculosis. |
| AID429427 | Antibacterial activity against Haemophilus influenzae isolate 282 by agar dilution method | 2009 | European journal of medicinal chemistry, Aug, Volume: 44, Issue:8 | Synthesis and antibacterial activity of novel 5-(4-methyl-1H-1,2,3-triazole) methyl oxazolidinones. |
| AID1778103 | Antibacterial activity against linezolid resistant Enterococcus faecium 13549 assessed as bacterial growth inhibition after 18 hrs by broth microdilution method | |||
| AID575146 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus isolate NRS123 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Inhibition of antibiotic-resistant Staphylococcus aureus by the broad-spectrum dihydrofolate reductase inhibitor RAB1. |
| AID285065 | Antimicrobial activity against beta hemolytic Streptococci group G at <= 0.06 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID348596 | Antibacterial activity against Enterococcus faecalis C474 after 18 to 20 hrs by agar dilution method | 2008 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 18, Issue:21 | Synthesis and antibacterial activities of novel oxazolidinones having cyclic sulfonamide moieties. |
| AID745382 | Antibacterial activity against methicillin-resistant Staphylococcus aureus SR3637 infected in JCL/ICR mouse systemic infection model assessed as mortality administered as iv measured over 7 days | 2013 | European journal of medicinal chemistry, May, Volume: 63 | Antibacterial oxazolidinone analogues having a N-hydroxyacetyl-substituted seven-membered [1,2,5]triazepane or [1,2,5]oxadiazepane C-ring unit. |
| AID576665 | Bactericidal activity against 48 hrs peripheral compartment culture samples of Enterococcus faecalis ATCC 29212 in two-compartment pharmacokinetic/pharmacodynamic model assessed as effect on bacterial count at 600 mg, bid for every 12 hrs administered as | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID495883 | Plasma concentration in Staphylococcus aureus COL infected New Zealand White rabbit aortic valve endocarditis model at 75 mg/kg, sc dosed every 8 hrs for 4 days | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Ceftobiprole is superior to vancomycin, daptomycin, and linezolid for treatment of experimental endocarditis in rabbits caused by methicillin-resistant Staphylococcus aureus. |
| AID590060 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus by agar dilution method | 2011 | European journal of medicinal chemistry, Apr, Volume: 46, Issue:4 | Discovery of torezolid as a novel 5-hydroxymethyl-oxazolidinone antibacterial agent. |
| AID1390476 | Antibacterial activity against Escherichia coli MG1655 | 2018 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 28, Issue:7 | Design, synthesis and biological evaluation of spiropyrimidinetriones oxazolidinone derivatives as antibacterial agents. |
| AID1174903 | Antibacterial activity against Staphylococcus aureus Mu50 ATCC 700699 by broth microdilution method | 2014 | Bioorganic & medicinal chemistry, Dec-15, Volume: 22, Issue:24 | New potent antibacterials against Gram-positive multiresistant pathogens: effects of side chain modification and chirality in linezolid-like 1,2,4-oxadiazoles. |
| AID458454 | Antimicrobial activity against Enterococcus faecalis ATCC 49532 at 2 mM after overnight incubation by agar diffusion method | 2010 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 20, Issue:3 | Syntheses and antibacterial activity studies of new oxazolidinones from nitroso Diels-Alder chemistry. |
| AID1519270 | Antibacterial activity agianst linezolid-resistant Enterococcus faecalis | 2019 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 29, Issue:23 | Synthesis and antibacterial evaluation of novel oxazolidinone derivatives containing a piperidinyl moiety. |
| AID516169 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus clinical isolates assessed as resistant isolates by EUCAST method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | In vitro activity of telavancin against a contemporary worldwide collection of Staphylococcus aureus isolates. |
| AID558508 | Antimicrobial activity against vancomycin-resistant Staphylococcus aureus 509 measured on day 20 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID1390472 | Antibacterial activity against methicillin-resistant Staphylococcus epidermidis ATCC 35984 | 2018 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 28, Issue:7 | Design, synthesis and biological evaluation of spiropyrimidinetriones oxazolidinone derivatives as antibacterial agents. |
| AID1117375 | Antimicrobial activity against Staphylococcus aureus Efs1 assessed as partially clear inhibition zone at 37 degC for 24 hrs by agar diffusion method | 2010 | MedChemComm, Aug-01, Volume: 1, Issue:2 | Syntheses and biological evaluation of new cephalosporin-oxazolidinone conjugates. |
| AID1168013 | Antibacterial activity against vancomycin-resistant Enterococcus faecium clinical isolate 3864 after overnight incubation by two-fold serial dilution method | 2014 | Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21 | Synthesis and biological evaluation of novel peptide BF2 as an antibacterial agent against clinical isolates of vancomycin-resistant enterococci. |
| AID1591560 | Bactericidal activity against Staphylococcus aureus ATCC 25923 assessed as 3 log reduction in number of colony forming units incubated for 24 hrs followed by aliquots transfer to tryptic soy agar and grown for 24 hrs | 2019 | Bioorganic & medicinal chemistry, 07-15, Volume: 27, Issue:14 | Discovery of 1,3,4-oxadiazol-2-one-containing benzamide derivatives targeting FtsZ as highly potent agents of killing a variety of MDR bacteria strains. |
| AID1680040 | Antibacterial activity against NDM1 producing carbapenem-resistant Enterobacteriaceae clinical isolate 6 assessed as reduction in bacterial growth incubated for 16 to 20 hrs by CLSI-based broth microdilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Synthesis and antibacterial bioactivities of cationic deacetyl linezolid amphiphiles. |
| AID1409850 | Antibacterial activity against linezolid-resistant Staphylococcus aureus NRS271 infected in BALB/c mouse assessed as reduction of bacterial burden in liver at 0.1 mg, ip bid administered at 12 hrs prior to bacterial infection dosed at 12 intervals for 4.5 | 2018 | ACS medicinal chemistry letters, Mar-08, Volume: 9, Issue:3 | Novel Staphyloxanthin Inhibitors with Improved Potency against Multidrug Resistant |
| AID564320 | Antimicrobial activity against log-phase methicillin-resistant Staphylococcus aureus HUSA 304 assessed as resistant bacteria in tissue cage fluid selected on 4 ug/ml of compound measured on day 8 post treatment | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | Efficacy of high doses of daptomycin versus alternative therapies against experimental foreign-body infection by methicillin-resistant Staphylococcus aureus. |
| AID575044 | Drug excretion in healthy human urine assessed as unchanged compound at at 600 mg, po | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Therapeutic drug monitoring of linezolid: a retrospective monocentric analysis. |
| AID285340 | Antibacterial activity against Staphylococcus aureus LUG855 in Mueller-Hinton medium | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Effect of antibiotics on Staphylococcus aureus producing Panton-Valentine leukocidin. |
| AID590061 | Antibacterial activity against vancomycin-resistant Enterococcus by agar dilution method | 2011 | European journal of medicinal chemistry, Apr, Volume: 46, Issue:4 | Discovery of torezolid as a novel 5-hydroxymethyl-oxazolidinone antibacterial agent. |
| AID1832942 | Antibacterial activity against Staphylococcus aureus 1199B assessed as reduction in bacterial growth incubated for 20 hrs by microplate reader method | 2021 | Bioorganic & medicinal chemistry, 11-01, Volume: 49 | Synthesis, microbiological evaluation and structure activity relationship analysis of linezolid analogues with different C5-acylamino substituents. |
| AID1056362 | Antibacterial activity against methicillin-resistant Staphylococcus aureus SR3637 clinical isolate assessed as parasite growth inhibition by CLSI broth microdilution method | 2013 | ACS medicinal chemistry letters, Nov-14, Volume: 4, Issue:11 | Potent oxazolidinone antibacterials with heteroaromatic C-ring substructure. |
| AID561740 | Antibacterial activity against Beta-hemolytic Streptococcus group A assessed as susceptible isolates by CLSI broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Potency and bactericidal activity of iclaprim against recent clinical gram-positive isolates. |
| AID1474203 | Antibacterial activity against Enterococcus faecium clinical isolates after 18 to 22 hrs by broth microdilution method | 2017 | Journal of medicinal chemistry, 03-23, Volume: 60, Issue:6 | Phenylthiazole Antibacterial Agents Targeting Cell Wall Synthesis Exhibit Potent Activity in Vitro and in Vivo against Vancomycin-Resistant Enterococci. |
| AID576415 | Apparent volume of distribution in two-compartment pharmacokinetic/pharmacodynamic model at 400 mg, bid administered as 0.5 hrs infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID206237 | In vitro antibacterial activity against Staphylococcus aures strain UC 9213 | 1996 | Journal of medicinal chemistry, Feb-02, Volume: 39, Issue:3 | Synthesis and antibacterial activity of U-100592 and U-100766, two oxazolidinone antibacterial agents for the potential treatment of multidrug-resistant gram-positive bacterial infections. |
| AID1395973 | Antibacterial activity against methicillin-resistant Staphylococcus aureus BAA-1707 after 16 to 18 hrs by broth microdilution method | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9 | An Efficient Buchwald-Hartwig/Reductive Cyclization for the Scaffold Diversification of Halogenated Phenazines: Potent Antibacterial Targeting, Biofilm Eradication, and Prodrug Exploration. |
| AID561727 | Antibacterial activity against Enterococcus faecium assessed as susceptible isolates by CLSI broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Potency and bactericidal activity of iclaprim against recent clinical gram-positive isolates. |
| AID1400046 | Antibacterial activity against Enterococcus faecalis ATCC 349 incubated for 24 hrs under aerobic condition by MABA | 2018 | Bioorganic & medicinal chemistry, 09-15, Volume: 26, Issue:17 | An antimycobacterial pleuromutilin analogue effective against dormant bacilli. |
| AID287261 | Antimicrobial activity against methicillin-susceptible coagulase-negative staphylococcus by agar dilution method | 2007 | European journal of medicinal chemistry, Feb, Volume: 42, Issue:2 | Structure-antibacterial activity of arylcarbonyl- and arylsulfonyl-piperazine 5-triazolylmethyl oxazolidinones. |
| AID1547716 | Antibacterial activity against vancomycin-susceptible Enterococcus faecalis 201 clinical isolate by broth microdilution method | 2020 | ACS medicinal chemistry letters, Mar-12, Volume: 11, Issue:3 | Structure-Activity Relationship for the Oxadiazole Class of Antibacterials. |
| AID54143 | Inhibitory activity against Corynebacterium | 1996 | Journal of medicinal chemistry, Sep-27, Volume: 39, Issue:20 | New directions in antibacterial research. |
| AID576428 | Bactericidal activity against 0.5 hrs peripheral compartment culture samples of Staphylococcus aureus RN4220 in two-compartment pharmacokinetic/pharmacodynamic model assessed as effect on bacterial count at 600 mg, bid administered as 0.5 hr infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID558524 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus 547 measured on day 30 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID563322 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis EF NJ1 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | In vivo activity of a novel anti-methicillin-resistant Staphylococcus aureus cephalosporin, ceftaroline, against vancomycin-susceptible and -resistant Enterococcus faecalis strains in a rabbit endocarditis model: a comparative study with linezolid and van |
| AID1304835 | Antibacterial activity against methicillin-resistant Staphylococcus aureus BAA-1707 incubated for 16 to 18 hrs by broth microdilution method | 2016 | Journal of medicinal chemistry, 04-28, Volume: 59, Issue:8 | Structure-Activity Relationships of a Diverse Class of Halogenated Phenazines That Targets Persistent, Antibiotic-Tolerant Bacterial Biofilms and Mycobacterium tuberculosis. |
| AID528690 | Antibacterial activity against Streptococcus pyogenes MED 2040 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID1699554 | Induction of cell membrane permeabilization in GFP-expressing Staphylococcus aureus ATCC 700699 assessed as increase in cellular ATP leakage at 5 fold MIC measured after 0.5 hrs by Bactiter-glo assay | 2020 | Journal of medicinal chemistry, 11-12, Volume: 63, Issue:21 | Nature-Inspired (di)Azine-Bridged Bisindole Alkaloids with Potent Antibacterial |
| AID1553384 | Inhibition of CYP3A4 (unknown origin) | 2019 | Bioorganic & medicinal chemistry letters, 09-15, Volume: 29, Issue:18 | Incorporation of a chiral gem-disubstituted nitrogen heterocycle yields an oxazolidinone antibiotic with reduced mitochondrial toxicity. |
| AID1184283 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 33591 infected in Swiss albino CD-1 mouse compound administered orally bid at 1 hr and 4 hrs post infection | 2014 | European journal of medicinal chemistry, Sep-12, Volume: 84 | Discovery of azetidine based ene-amides as potent bacterial enoyl ACP reductase (FabI) inhibitors. |
| AID520229 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus BK 11512 | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID541053 | Ratio of AUC (0 to 24 hrs) to MIC for methicillin-resistant Staphylococcus aureus ATCC 43300 in Albino guiena pig model of foreign-body infection at 25 mg/kg, ip | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Linezolid alone or combined with rifampin against methicillin-resistant Staphylococcus aureus in experimental foreign-body infection. |
| AID532792 | Antibacterial activity against vancomycin-intermediate Staphylococcus aureus 99/3700-W after 24 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Improved antimicrobial activity of linezolid against vancomycin-intermediate Staphylococcus aureus. |
| AID542890 | fCmax in Bacillus anthracis infected in vitro hollow fiber PK/PD model at simulated dose of 400 mg administered every 12 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID1139117 | Antimicrobial activity against Streptococcus pneumoniae in presence of 50% human serum | 2014 | Bioorganic & medicinal chemistry letters, May-01, Volume: 24, Issue:9 | Successful application of serum shift prediction models to the design of dual targeting inhibitors of bacterial gyrase B and topoisomerase IV with improved in vivo efficacy. |
| AID574077 | Apparent oral clearance in CF-1 mouse at 10 mg/kg, po | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | In vivo activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. |
| AID582810 | Antimicrobial activity against glycopeptide-resistant Enterococcus faecalis isolate HS05417 harboring MLST sequence type ST17 and pulsotype A expressing vanA gene cluster isolated from urine of patient by Etest | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | vanM, a new glycopeptide resistance gene cluster found in Enterococcus faecium. |
| AID1770363 | Ratio of MBC to MIC against penicillin-resistant Staphylococcus aureus ATCC 31007 | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Modification of 5-methylphenanthridium from benzothiazoles to indoles as potent FtsZ inhibitors: Broadening the antibacterial spectrum toward vancomycin-resistant enterococci. |
| AID284951 | Antimicrobial activity against Bacillus cereus at <= 0.06 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID274225 | Antibacterial activity against Streptococcus pneumoniae SVI SP-3 | 2006 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 16, Issue:20 | Synthesis and structure-activity studies of novel benzocycloheptanone oxazolidinone antibacterial agents. |
| AID285105 | Antimicrobial activity against viridans group Streptococcus mitis at 2 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID1594389 | Half life in human at 625 mg, iv | 2019 | Bioorganic & medicinal chemistry, 05-01, Volume: 27, Issue:9 | Second-generation aryl isonitrile compounds targeting multidrug-resistant Staphylococcus aureus. |
| AID374010 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus 543 after 15 passages with Linezolid measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID645035 | Antibacterial activity against erythromycin-resistant Streptococcus pyogenes 47 after 16 to 20 hrs by microbroth dilution method | 2012 | European journal of medicinal chemistry, Apr, Volume: 50 | Synthesis and preliminary antibacterial evaluation of Linezolid-like 1,2,4-oxadiazole derivatives. |
| AID319157 | Plasma concentration in human at 625 mg, po bid after 14 days | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7 | Linezolid (ZYVOX), the first member of a completely new class of antibacterial agents for treatment of serious gram-positive infections. |
| AID583888 | Antibacterial activity against hospital-associated methicillin-resistant Staphylococcus aureus isolate 336 by broth microdilution assay | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Comparative efficacies of human simulated exposures of telavancin and vancomycin against methicillin-resistant Staphylococcus aureus with a range of vancomycin MICs in a murine pneumonia model. |
| AID318351 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus | 2007 | Proceedings of the National Academy of Sciences of the United States of America, May-01, Volume: 104, Issue:18 | Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties. |
| AID1361049 | Antibacterial activity against methicillin-resistant Staphylococcus epidermidis ATCC 35984 after 16 to 18 hrs by broth microdilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Halogenated quinolines bearing polar functionality at the 2-position: Identification of new antibacterial agents with enhanced activity against Staphylococcus epidermidis. |
| AID373844 | Antimicrobial activity against methicillin and vancomycin-resistant Staphylococcus aureus 509 after single-step resistance selection by agar dilution CLSI method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID542920 | Antimicrobial activity against wild-type Bacillus anthracis | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID544825 | Antimicrobial activity against Staphylococcus aureus Xen 30 biofilm assessed as log10 CFU/cm'2 in bacterial count in presence of 2000 microamperes of electric current by bioelectric effect assay | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Effect of electrical current on the activities of antimicrobial agents against Pseudomonas aeruginosa, Staphylococcus aureus, and Staphylococcus epidermidis biofilms. |
| AID561234 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus assessed as susceptible isolates by CLSI M100-S17 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | AFN-1252, a FabI inhibitor, demonstrates a Staphylococcus-specific spectrum of activity. |
| AID374012 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus 543 after 50 passages with vancomycin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID528966 | Antimicrobial activity against methicillin-susceptible Staphylococcus epidermidis isolated from ICU patient urine assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID576652 | Bactericidal activity against 12.5 hrs peripheral compartment culture samples of Enterococcus faecalis ATCC 29212 in two-compartment pharmacokinetic/pharmacodynamic model assessed as effect on bacterial count at 200 mg, bid administered as 0.5 hr infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID532785 | Antibacterial activity against vancomycin-intermediate Staphylococcus aureus BR5-1 after 24 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Improved antimicrobial activity of linezolid against vancomycin-intermediate Staphylococcus aureus. |
| AID373822 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus 543 after 15 passages by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID1395676 | Antibacterial activity against methicillin-resistant Staphylococcus aureus NRS123 USA400 after 18 hrs by broth microdilution assay | 2018 | European journal of medicinal chemistry, May-10, Volume: 151 | Phenylthiazoles with tert-Butyl side chain: Metabolically stable with anti-biofilm activity. |
| AID561734 | Antibacterial activity against Beta-hemolytic Streptococcus group B assessed as resistant isolates by CLSI broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Potency and bactericidal activity of iclaprim against recent clinical gram-positive isolates. |
| AID1611122 | Antibacterial activity against vancomycin-resistant Enterococcus faecium CLSI-based double dilution method | 2019 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 29, Issue:23 | Design and synthesis of biaryloxazolidinone derivatives containing amide or acrylamide moiety as novel antibacterial agents against Gram-positive bacteria. |
| AID285001 | Antimicrobial activity against Enterococcus gallinarum at 0.12 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID429424 | Antibacterial activity against vancomycin-resistant Enterococcus by agar dilution method | 2009 | European journal of medicinal chemistry, Aug, Volume: 44, Issue:8 | Synthesis and antibacterial activity of novel 5-(4-methyl-1H-1,2,3-triazole) methyl oxazolidinones. |
| AID533952 | Antimicrobial activity against Staphylococcus epidermidis SA362 after 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Cellular pharmacodynamics of the novel biaryloxazolidinone radezolid: studies with infected phagocytic and nonphagocytic cells, using Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Legionella pneumophila. |
| AID1167731 | Antimicrobial activity against Streptococcus pneumoniae by broth microdilution method | 2014 | Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21 | Novel DNA gyrase inhibiting spiropyrimidinetriones with a benzisoxazole scaffold: SAR and in vivo characterization. |
| AID283633 | Antimicrobial activity against Staphylococcus aureus RN4220 with 23S rRNA G2447T mutation | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | In vitro activity of the oxazolidinone RWJ-416457 against linezolid-resistant and -susceptible staphylococci and enterococci. |
| AID560357 | Cmax in healthy human male at 600 mg, po every 12 hrs by LC/MS/MS analysis | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Impact of human serum albumin on oritavancin in vitro activity against enterococci. |
| AID555303 | Antibacterial activity against methicillin-resistant Staphylococcus aureus 145 by broth macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Antistaphylococcal activity of dihydrophthalazine antifolates, a family of novel antibacterial drugs. |
| AID1435929 | Bactericidal activity against methicillin/ciprofloxacin/gentamicin/clindamycin-resistant Staphylococcus aureus USA200 NRS383 clinical isolate after 24 hrs | 2017 | European journal of medicinal chemistry, Jan-27, Volume: 126 | Phenylthiazole antibiotics: A metabolism-guided approach to overcome short duration of action. |
| AID1721017 | Stability in CD-1 mouse liver microsome assessed as parent compound remaining at 1 uM measured after 30 mins in presence of NADPH by LC-MS/MS analysis | 2020 | Journal of medicinal chemistry, 09-10, Volume: 63, Issue:17 | Discovery of a Conformationally Constrained Oxazolidinone with Improved Safety and Efficacy Profiles for the Treatment of Multidrug-Resistant Tuberculosis. |
| AID1474261 | Ratio of MBC50 to MIC50 for Enterococcus faecalis clinical isolates | 2017 | Journal of medicinal chemistry, 03-23, Volume: 60, Issue:6 | Phenylthiazole Antibacterial Agents Targeting Cell Wall Synthesis Exhibit Potent Activity in Vitro and in Vivo against Vancomycin-Resistant Enterococci. |
| AID558703 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus 540 measured on day 35 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID208733 | Compound was evaluated for minimum inhibitory concentration against Streptococcus A 44 strain | 2002 | Bioorganic & medicinal chemistry letters, Mar-25, Volume: 12, Issue:6 | Synthesis and antibacterial activity of linezolid analogues. |
| AID523777 | Antimicrobial activity against linezolid-susceptible Staphylococcus aureus assessed as percent susceptible strain by CLSI method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative activities of TR-700 (torezolid) against staphylococcal blood isolates collected in Spain. |
| AID559564 | Antimicrobial activity against compound-susceptible Coxiella burnetii isolate CP8 obtained from patient with acute Q fever infected in african green monkey Vero cells after 24 hrs by shell vial assay | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Bacteriostatic and bactericidal activities of tigecycline against Coxiella burnetii and comparison with those of six other antibiotics. |
| AID1609270 | Antibacterial activity against methicillin-resistant Staphylococcus epidermidis NRS101 after 18 to 20 hrs by CLSI-based broth microdilution assay | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Phenylthiazoles with nitrogenous side chain: An approach to overcome molecular obesity. |
| AID297132 | Antibacterial activity against Pseudomonas aeruginosa 46001 by agar plate dilution method | 2007 | Journal of medicinal chemistry, Aug-23, Volume: 50, Issue:17 | Discovery of 1,4-dihydroxy-2-naphthoate [corrected] prenyltransferase inhibitors: new drug leads for multidrug-resistant gram-positive pathogens. |
| AID1367596 | Efflux index, ratio of MIC for wild type Escherichia coli MG1655 to MIC for Escherichia coli MG1655 expressing AcrAB-TolC efflux pump deletion mutant | 2017 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23 | Compound design guidelines for evading the efflux and permeation barriers of Escherichia coli with the oxazolidinone class of antibacterials: Test case for a general approach to improving whole cell Gram-negative activity. |
| AID534248 | Antimicrobial activity against linezolid-susceptible Staphylococcus aureus SA238 infected in THP1 cells at pH 7.4 after 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Cellular pharmacodynamics of the novel biaryloxazolidinone radezolid: studies with infected phagocytic and nonphagocytic cells, using Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Legionella pneumophila. |
| AID409580 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus after 16 to 18 hrs by agar dilution method | 2008 | European journal of medicinal chemistry, Aug, Volume: 43, Issue:8 | Synthesis and biological evaluation of new N-linked 5-triazolylmethyl oxazolidinones. |
| AID410219 | Antibacterial activity against Escherichia coli LCB0010 at 128 ug/mL by broth micro dilution method | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24 | A facile synthesis, antibacterial, and antitubercular studies of some piperidin-4-one and tetrahydropyridine derivatives. |
| AID533754 | Antimicrobial activity against hospital acquired methicillin-resistant Staphylococcus aureus ATCC 33591 after 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Cellular pharmacodynamics of the novel biaryloxazolidinone radezolid: studies with infected phagocytic and nonphagocytic cells, using Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Legionella pneumophila. |
| AID1760592 | Antibacterial activity against Enterococcus faecium 35667 assessed as inhibition of bacterial growth measured after 24 hrs | 2021 | European journal of medicinal chemistry, Feb-05, Volume: 211 | Installation of an aryl boronic acid function into the external section of N-aryl-oxazolidinones: Synthesis and antimicrobial evaluation. |
| AID1395988 | Induction of biofilm eradication of vancomycin-resistant Enterococcus faecium ATCC 700221 after 24 hrs by calgary biofilm device method | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9 | An Efficient Buchwald-Hartwig/Reductive Cyclization for the Scaffold Diversification of Halogenated Phenazines: Potent Antibacterial Targeting, Biofilm Eradication, and Prodrug Exploration. |
| AID1151760 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus ATCC 29213 in po dosed mouse systemic infection model | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID424763 | Antibacterial activity against Staphylococcus epidermidis CL8040 after 20 hrs by twofold serial broth dilution method | 2009 | Journal of natural products, May-22, Volume: 72, Issue:5 | Thiazomycins, thiazolyl peptide antibiotics from Amycolatopsis fastidiosa. |
| AID444052 | Hepatic clearance in human | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3 | Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. |
| AID555499 | Antibacterial activity against methicillin-susceptible coagulase-negative Staphylococcus epidermidis 051 after 50 passages by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Antistaphylococcal activity of dihydrophthalazine antifolates, a family of novel antibacterial drugs. |
| AID387449 | Antibacterial activity against methicillin-resistant Staphylococcus aureus DRCC 019 | 2008 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 18, Issue:18 | Novel and potent oxazolidinone antibacterials featuring 3-indolylglyoxamide substituents. |
| AID1304834 | Antibacterial activity against methicillin-resistant Staphylococcus aureus BAA-44 incubated for 16 to 18 hrs by broth microdilution method | 2016 | Journal of medicinal chemistry, 04-28, Volume: 59, Issue:8 | Structure-Activity Relationships of a Diverse Class of Halogenated Phenazines That Targets Persistent, Antibiotic-Tolerant Bacterial Biofilms and Mycobacterium tuberculosis. |
| AID522904 | Antibacterial activity against vancomycin-intermediate Staphylococcus aureus isolate 1005 after 24 hrs by modified broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Antistaphylococcal activity of ACHN-490 tested alone and in combination with other agents by time-kill assay. |
| AID1361122 | Bacteriostatic activity against Pseudomonas aeruginosa ATCC 15442 after 20 hrs by broth microdilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | N-(1,3,4-oxadiazol-2-yl)benzamide analogs, bacteriostatic agents against methicillin- and vancomycin-resistant bacteria. |
| AID753124 | Antibacterial activity against Micrococcus luteus MTCC 2470 assessed as growth inhibition after 24 hrs by agar dilution method | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | Anti-tubercular agents. Part 7: a new class of diarylpyrrole-oxazolidinone conjugates as antimycobacterial agents. |
| AID373846 | Antimicrobial activity against vancomycin-resistant Staphylococcus aureus 510 Hershey after 18 passages with daptomycin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID575080 | Antimicrobial activity against Streptococcus pneumoniae serotype 11A assessed as percent susceptible isolates by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID576126 | Antibacterial activity against 1 x 10'7 CFU methicillin-susceptible Staphylococcus aureus Giorgio infected in ICR mouse systemic infection model assessed as mouse protection administered orally twice after 1 and 4 hrs post infection measured after 48 hrs | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | In vitro and in vivo activities of LCB01-0371, a new oxazolidinone. |
| AID576399 | Residual concentration at the end of the administration interval in two-compartment pharmacokinetic/pharmacodynamic model at 200 mg, bid administered as 0.5 hrs infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID561339 | Antimicrobial activity against Staphylococcus aureus isolate UAMS-929 harboring sarA gene mutant by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Impact of sarA on antibiotic susceptibility of Staphylococcus aureus in a catheter-associated in vitro model of biofilm formation. |
| AID1653082 | Antibacterial activity against Bacillus megaterium | 2019 | European journal of medicinal chemistry, Feb-15, Volume: 164 | Isatin derivatives and their anti-bacterial activities. |
| AID562637 | Antimicrobial activity against Listeria monocytogenes assessed as susceptible isolates by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | In vitro activities of three new dihydrofolate reductase inhibitors against clinical isolates of gram-positive bacteria. |
| AID532023 | Antimicrobial activity against Mycobacterium ulcerans ATCC 19423 harboring pTY60K containing pMH94 carrying the luxAB gene under the hsp60 promoter after 7 days determined according to CFU count by bioluminescence method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Rapid assessment of antibacterial activity against Mycobacterium ulcerans by using recombinant luminescent strains. |
| AID285137 | Antimicrobial activity against viridans group Streptococcus vestibularis at 0.12 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID1271223 | Antibacterial activity against Streptococcus pneumoniae ATCC 49619 by microbroth dilution method | 2015 | ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11 | Design, Synthesis, and Identification of Silicon Incorporated Oxazolidinone Antibiotics with Improved Brain Exposure. |
| AID1424066 | Antibiotic activity against methicillin-resistant Staphylococcus aureus isolate CAIRD116 by broth microdilution assay or Alamar blue dye based colorimetric assay | 2017 | Journal of natural products, 04-28, Volume: 80, Issue:4 | The Berkeleylactones, Antibiotic Macrolides from Fungal Coculture. |
| AID1609288 | Antibacterial activity against methicilline-sensitive Staphylococcus aureus ATCC 6538 after 18 to 20 hrs by CLSI-based broth microdilution assay | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Phenylthiazoles with nitrogenous side chain: An approach to overcome molecular obesity. |
| AID40483 | Minimum inhibitory concentration against Bacillus pumilus MTCC 1607 | 2004 | Bioorganic & medicinal chemistry letters, Jun-21, Volume: 14, Issue:12 | Oxazolidinone: search for highly potent antibacterial. |
| AID726187 | Inhibition of human MAO-A assessed as residual activity at 10 uM | 2013 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 23, Issue:5 | Synthesis and antibacterial activities of new piperidine substituted (5R)-[1,2,3]triazolylmethyl and (5R)-[(4-F-[1,2,3]triazolyl)methyl] oxazolidinones. |
| AID558507 | Antimicrobial activity against vancomycin-resistant Staphylococcus aureus 510 measured on day 20 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID474997 | Antibacterial activity against methicillin-resistant Staphylococcus aureus LCB0002 by two fold serial dilution method | 2010 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 20, Issue:7 | Synthesis, crystal and antibacterial studies of diversely functionalized tetrahydropyridin-4-ol. |
| AID1692901 | Antibacterial activity against methicillin-resistant Staphylococcus aureus | 2021 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 32 | Design, synthesis and antibacterial evaluation of novel oxazolidinone derivatives nitrogen-containing fused heterocyclic moiety. |
| AID576410 | AUC in two-compartment pharmacokinetic/pharmacodynamic model at 800 mg, bid administered as 0.5 hrs infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID498906 | fAUC (0-infinity) in immunocompetent SKH1 mouse plasma at 50 mg/kg, po | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vivo activity of ceftobiprole in murine skin infections due to Staphylococcus aureus and Pseudomonas aeruginosa. |
| AID734690 | Antibacterial activity against Micrococcus luteus MTCC 2470 at 20 ug/ml after 24 hrs by disk diffusion method | 2013 | European journal of medicinal chemistry, Apr, Volume: 62 | Synthesis, biological evaluation of new oxazolidino-sulfonamides as potential antimicrobial agents. |
| AID528712 | Antibacterial activity against methicillin resistant coagulase-negative Staphylococcus hominis subsp. novobiosepticus clinical isolate assessed as susceptibility level by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID560513 | Antimicrobial activity against SCCmec type III vancomycin-intermediate Staphylococcus aureus isolate b6k7974 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID1547705 | Antibacterial activity against Staphylococcus aureus N315 (NRS70) by broth microdilution method | 2020 | ACS medicinal chemistry letters, Mar-12, Volume: 11, Issue:3 | Structure-Activity Relationship for the Oxadiazole Class of Antibacterials. |
| AID292611 | Antimicrobial activity against Streptococcus pyogenes ATCC 19615 by agar dilution method | 2007 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 17, Issue:17 | Synthesis and antibacterial activity of novel oxazolidinones with methylene oxygen- and methylene sulfur-linked substituents at C5-position. |
| AID1395982 | Induction of biofilm eradication of methicillin-resistant Staphylococcus aureus 2 after 24 hrs by calgary biofilm device method | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9 | An Efficient Buchwald-Hartwig/Reductive Cyclization for the Scaffold Diversification of Halogenated Phenazines: Potent Antibacterial Targeting, Biofilm Eradication, and Prodrug Exploration. |
| AID759678 | Cytotoxicity against porcine PK-15 cells assessed as stimulation of cell replication at 400 ug/mL | 2013 | European journal of medicinal chemistry, Jul, Volume: 65 | New linezolid-like 1,2,4-oxadiazoles active against Gram-positive multiresistant pathogens. |
| AID1193406 | Antimicrobial activity against TolC-deficient Escherichia coli BW25113 measured after overnight incubation | 2015 | Bioorganic & medicinal chemistry, Apr-01, Volume: 23, Issue:7 | Identification of Bacillus anthracis PurE inhibitors with antimicrobial activity. |
| AID284962 | Antimicrobial activity against Corynebacterium spp. at 2 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID391593 | Antibacterial activity against vancomycin-resistant Enterococcus faecium A2280 by agar dilution method | 2008 | Journal of medicinal chemistry, Oct-23, Volume: 51, Issue:20 | Synthesis and structure-activity relationship studies of highly potent novel oxazolidinone antibacterials. |
| AID576894 | Ratio of Cmax to MIC for 0.5 hrs peripheral compartment culture samples of Enterococcus faecalis Ef1497MutM3 in two-compartment pharmacokinetic/pharmacodynamic model at 200 mg, bid administered as 0.5 hr infusion for 2 days | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID283385 | Decrease in mitochondrial Cytochrome C oxidase protein expression in PBMCs from patient on a long-term schedule of the drug with hyperlactatemia relative to control | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Reversible inhibition of mitochondrial protein synthesis during linezolid-related hyperlactatemia. |
| AID542693 | fT>MIC in Bacillus anthracis infected in vitro hollow fiber PK/PD model at simulated dose of 600 mg administered every 24 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID373306 | Lipophilicity, log P of the compound | 2009 | European journal of medicinal chemistry, Mar, Volume: 44, Issue:3 | Synthesis, antibacterial and anticonvulsant evaluations of some cyclic enaminones. |
| AID1553370 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 measured after 18 hrs by broth microdilution method | 2019 | Bioorganic & medicinal chemistry letters, 09-15, Volume: 29, Issue:18 | Incorporation of a chiral gem-disubstituted nitrogen heterocycle yields an oxazolidinone antibiotic with reduced mitochondrial toxicity. |
| AID1271218 | AUC (0 to t) in BALB/c mouse plasma at 10 mg/kg, po by LC-MS/MS analysis | 2015 | ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11 | Design, Synthesis, and Identification of Silicon Incorporated Oxazolidinone Antibiotics with Improved Brain Exposure. |
| AID283389 | Effect on mitochondrial mass in PBMCs from patient during hyperlactemic phase by V-DAC method relative to control | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Reversible inhibition of mitochondrial protein synthesis during linezolid-related hyperlactatemia. |
| AID561724 | Antibacterial activity against Enterococcus faecium assessed as resistant isolates by CLSI broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Potency and bactericidal activity of iclaprim against recent clinical gram-positive isolates. |
| AID1311366 | Antibacterial activity against methicillin-sensitive Mycobacterium tuberculosis H37Rv measured after 14 days by broth microdilution assay | 2016 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15 | An evolved oxazolidinone with selective potency against Mycobacterium tuberculosis and gram positive bacteria. |
| AID533951 | Antimicrobial activity against hospital acquired methicillin-resistant, vancomycin resistant Staphylococcus aureus VRS2 after 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Cellular pharmacodynamics of the novel biaryloxazolidinone radezolid: studies with infected phagocytic and nonphagocytic cells, using Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Legionella pneumophila. |
| AID534507 | Drug level in human THP1 cells at 250 mg/L after 2 hrs in presence of 50 uM proton inophore monesin relative to control | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Cellular pharmacokinetics of the novel biaryloxazolidinone radezolid in phagocytic cells: studies with macrophages and polymorphonuclear neutrophils. |
| AID205681 | Minimum inhibitory concentration against Staphylococcus aureus OC 4172 in precense of 50% mouse serum | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | Synthesis and antibacterial activity of pyrroloaryl-substituted oxazolidinones. |
| AID1151623 | Toxicity in female rat assessed as effect on hemoglobin level at 100 mg/kg/day, po bid administered for 4 weeks (Rvb = 141.8 g/L) | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID374002 | Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus 555 Hershey after 50 passages with vancomycin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID1873890 | Antibacterial activity against Staphylococcus aureus ATCC 29213 incubated for 16 to 20 hrs using 10^5 CFU/ml bacterial inoculum by broth microdilution method | 2022 | European journal of medicinal chemistry, Aug-05, Volume: 238 | Design, synthesis and activity against drug-resistant bacteria evaluation of C-20, C-23 modified 5-O-mycaminosyltylonolide derivatives. |
| AID263965 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis DRCC 154 | 2006 | Bioorganic & medicinal chemistry letters, May-01, Volume: 16, Issue:9 | Synthesis and antibacterial activity of novel oxazolidinones bearing N-hydroxyacetamidine substituent. |
| AID560827 | AUC (0 to 12 hrs) in human adults with pulmonary tuberculosis at 600 mg administered twice daily for 5 days | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Population pharmacokinetics of linezolid in adults with pulmonary tuberculosis. |
| AID522893 | Antibacterial activity against vancomycin-intermediate Staphylococcus aureus isolate 1010 after 24 hrs by modified broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Antistaphylococcal activity of ACHN-490 tested alone and in combination with other agents by time-kill assay. |
| AID545816 | Antimicrobial activity against 4.6 X 10'6 CFU/peg methicillin-resistant Staphylococcus aureus ATCC 33591 assessed as inhibition of biofilm formation after 24 hrs by serial dilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Oritavancin kills stationary-phase and biofilm Staphylococcus aureus cells in vitro. |
| AID576429 | Bactericidal activity against 1 hr peripheral compartment culture samples of Staphylococcus aureus RN4220 in two-compartment pharmacokinetic/pharmacodynamic model assessed as effect on bacterial count at 600 mg, bid administered as 0.5 hr infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID206647 | Antibacterial activity against methicillin susceptible Staphylococcus aureus (MSSA) | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | Iclaprim, a novel diaminopyrimidine with potent activity on trimethoprim sensitive and resistant bacteria. |
| AID285014 | Antimicrobial activity against Enterococcus raffinosus at 0.12 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID572486 | Antimicrobial activity against Streptococcus pneumoniae ATCC 6303 infected in po dosed NMRI mouse administered thrice daily for 4 days | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vivo characterization of the peptide deformylase inhibitor LBM415 in murine infection models. |
| AID1271230 | Antibacterial activity against clinical isolate Neisseria meningitidis E-95 by microbroth dilution method | 2015 | ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11 | Design, Synthesis, and Identification of Silicon Incorporated Oxazolidinone Antibiotics with Improved Brain Exposure. |
| AID396028 | Antibacterial activity against drug-resistant AcrAB-TolC efflux pump deficient Enterobacter cloacae EcdeltaacrA isolate by Etest | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Cloning, nucleotide sequencing, and analysis of the AcrAB-TolC efflux pump of Enterobacter cloacae and determination of its involvement in antibiotic resistance in a clinical isolate. |
| AID284959 | Antimicrobial activity against Corynebacterium spp. at 0.25 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID1703714 | Antibacterial activity against methicillin-resistant Staphylococcus aureus USA500 NRS385 assessed as inhibition of bacterial growth measured after 18 to 20 hrs by CLSI protocol based broth microdilution method | 2020 | European journal of medicinal chemistry, Sep-15, Volume: 202 | Evaluation of N-phenyl-2-aminothiazoles for treatment of multi-drug resistant and intracellular Staphylococcus aureus infections. |
| AID10894 | Tmax in male rat | 2003 | Bioorganic & medicinal chemistry letters, Jul-07, Volume: 13, Issue:13 | Synthesis and in vitro activity of new methylenepiperidinyl and methylenepyrrolidinyl oxazolidinone antibacterial agents. |
| AID67094 | Compound was evaluated for minimum inhibitory concentration against Enterococcus faecalis 68 strain | 2002 | Bioorganic & medicinal chemistry letters, Mar-25, Volume: 12, Issue:6 | Synthesis and antibacterial activity of linezolid analogues. |
| AID283161 | Antimicrobial susceptibility of Staphylococcus lugdunensis IDRL2588 biofilms after 24 hrs assessed as bacterial regrowth | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | In vitro effects of antimicrobial agents on planktonic and biofilm forms of Staphylococcus lugdunensis clinical isolates. |
| AID1704213 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 33591 incubated for 18 hrs | 2020 | European journal of medicinal chemistry, Nov-15, Volume: 206 | 1,2,3-Triazole-containing hybrids with potential antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA). |
| AID576395 | Cmax in two-compartment pharmacokinetic/pharmacodynamic model at 800 mg, bid administered as 0.5 hrs infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID763982 | Antibacterial activity against vancomycin-resistant Enterococcus after 18 hrs by NCCLS agar dilution method | 2013 | European journal of medicinal chemistry, Aug, Volume: 66 | Synthesis and antibacterial activities of N-substituted-glycinyl 1H-1,2,3-triazolyl oxazolidinones. |
| AID1501364 | Bactericidal activity against methicillin-resistant Staphylococcus aureus NRS123 (USA400) incubated for 20 hrs followed by replating on tryptic soy agar plates and further incubated for 18 hrs by broth microdilution assay | 2017 | European journal of medicinal chemistry, Oct-20, Volume: 139 | Arylthiazole antibiotics targeting intracellular methicillin-resistant Staphylococcus aureus (MRSA) that interfere with bacterial cell wall synthesis. |
| AID533987 | Bacteriostatic activity against linezolid-susceptible Staphylococcus aureus SA238 infected in THP1 cells after 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Cellular pharmacodynamics of the novel biaryloxazolidinone radezolid: studies with infected phagocytic and nonphagocytic cells, using Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Legionella pneumophila. |
| AID207646 | Antibacterial activity against Staphylococcus aureus UC9213 | 1998 | Bioorganic & medicinal chemistry letters, May-19, Volume: 8, Issue:10 | Synthesis and antibacterial activity of [6,5,5] and [6,6,5] tricyclic fused oxazolidinones. |
| AID542895 | fAUC (24 hrs) in Bacillus anthracis infected in vitro hollow fiber PK/PD model at simulated dose of 500 mg administered every 12 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID285350 | Antibacterial activity against community acquired methicillin-resistant Staphylococcus aureus HT20040332 in CCY media | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Effect of antibiotics on Staphylococcus aureus producing Panton-Valentine leukocidin. |
| AID1350037 | Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate 8 incubated overnight by agar dilution method | 2018 | Journal of natural products, 02-23, Volume: 81, Issue:2 | Biomimetic Stereoselective Sulfa-Michael Addition Leads to Platensimycin and Platencin Sulfur Analogues against Methicillin-Resistant Staphylococcus aureus. |
| AID558716 | Antimicrobial activity against vancomycin-resistant Staphylococcus aureus 509 measured on day 40 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID577104 | AUBC (0 to 24 hrs) in Enterococcus faecalis ATCC 29212 in two-compartment pharmacokinetic/pharmacodynamic model at 200 mg, bid administered as 0.5 hr infusion for 2 days | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID1197126 | Antibacterial activity against Bacillus licheniformis ATCC 12759 after 16 to 20 hrs by broth microdilution method | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3 | Structure-activity relationship for the oxadiazole class of antibiotics. |
| AID1414190 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after 24 hrs by broth microdilution based CLSI method | 2018 | European journal of medicinal chemistry, Nov-05, Volume: 159 | Design, synthesis and structure-based optimization of novel isoxazole-containing benzamide derivatives as FtsZ modulators. |
| AID576884 | Ratio of Cmax to MIC for 0.5 hrs peripheral compartment culture samples of Staphylococcus aureus RN4220 MutS2 in two-compartment pharmacokinetic/pharmacodynamic model at 600 mg, bid administered as 0.5 hr infusion for 2 days | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID577126 | Residual concentration at the end of the administration interval in two-compartment pharmacokinetic/pharmacodynamic model at 800 mg, bid administered as 0.5 hr infusion over 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID1596563 | Bactericidal activity against methicillin-resistant Staphylococcus aureus USA300 assessed as reduction in bacterial cell growth incubated for 18 to 20 hrs followed by re-plating on tryptic soy agar plates at 37 degC for 18 hrs by broth microdilution assay | 2019 | European journal of medicinal chemistry, Aug-01, Volume: 175 | Lipophilic efficient phenylthiazoles with potent undecaprenyl pyrophosphatase inhibitory activity. |
| AID560509 | Antimicrobial activity against SCCmec type III vancomycin-intermediate Staphylococcus aureus isolate b4k6307 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID285341 | Antibacterial activity against community acquired methicillin-resistant Staphylococcus aureus HT20010734 in in Mueller-Hinton medium | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Effect of antibiotics on Staphylococcus aureus producing Panton-Valentine leukocidin. |
| AID564321 | Antimicrobial activity against log-phase methicillin-resistant Staphylococcus aureus HUSA 304 assessed as resistant bacteria in tissue cage fluid selected on 4 ug/ml of compound measured on day 11 post treatment | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | Efficacy of high doses of daptomycin versus alternative therapies against experimental foreign-body infection by methicillin-resistant Staphylococcus aureus. |
| AID85980 | In vitro antibacterial activity against ampicillin resistant Haemophilus influenzae 30063 (AMPR b-lactamase+) | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | The effect of remote chirality on the antibacterial activity of indolinyl, tetrahydroquinolyl and dihydrobenzoxazinyl oxazolidinones. |
| AID1653047 | Antibacterial activity against Staphylococcus aureus | 2019 | European journal of medicinal chemistry, Feb-15, Volume: 164 | Isatin derivatives and their anti-bacterial activities. |
| AID373830 | Antimicrobial activity against panton-valentine leukocidin-positive community-acquired methicillin-resistant Staphylococcus aureus 490 after 14 passages with daptomycin measured after 10 antibiotic-free subculture by multi-step resistance selection techni | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID1374168 | Antibacterial activity against Staphylococcus aureus ATCC 6538 incubated at 37 degC for 20 hrs by agar dilution method | 2018 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4 | Design, synthesis and antibacterial evaluation of honokiol derivatives. |
| AID363436 | Antibacterial activity against Streptococcus pneumoniae ATCC 6303-infeceted Sprague-Dawley rat assessed as reduction in lung bacterial density at 50 mg/kg, po administered twice at 18 and 26 hrs after bacterial challenge measured at 72 hrs postinfection | 2008 | Journal of medicinal chemistry, Sep-11, Volume: 51, Issue:17 | Novel dual-targeting benzimidazole urea inhibitors of DNA gyrase and topoisomerase IV possessing potent antibacterial activity: intelligent design and evolution through the judicious use of structure-guided design and structure-activity relationships. |
| AID525132 | Antibacterial activity against Staphylococcus aureus KM53 after 18 to 24 hrs by broth microdilution method selected after 16 ug/ml drug exposure for 6 hrs by culture absorbance method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Delayed development of linezolid resistance in Staphylococcus aureus following exposure to low levels of antimicrobial agents. |
| AID562233 | Antibacterial activity against methicillin-resistant Staphylococcus aureus OC2878 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Pharmacokinetic-pharmacodynamic modeling of the in vitro activities of oxazolidinone antimicrobial agents against methicillin-resistant Staphylococcus aureus. |
| AID284958 | Antimicrobial activity against Corynebacterium spp. at 0.12 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID1603255 | Antibacterial activity against Mycobacterium tuberculosis H37Rv harboring LuxAB incubated for 10 days under anaerobic conditions followed by incubation under aerobic conditions for 28 hrs by LORA method | |||
| AID1677795 | Bacteriostatic activity against methicillin-resistant Staphylococcus aureus ATCC43300 assessed as ratio of MBC to MIC | 2020 | Bioorganic & medicinal chemistry, 11-01, Volume: 28, Issue:21 | Design, synthesis of novel 4,5-dihydroisoxazole-containing benzamide derivatives as highly potent FtsZ inhibitors capable of killing a variety of MDR Staphylococcus aureus. |
| AID531645 | Displacement of [3H]puromycin from 70S ribosomal complex in Staphylococcus aureus ATCC 29213 by competitive binding assay | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | R chi-01, a new family of oxazolidinones that overcome ribosome-based linezolid resistance. |
| AID671568 | Antibacterial activity against methicillin-resistant Staphylococcus aureus VL-137 infected in neutropenic Balb/c mouse assessed as reduction in lung CFU at 10 mg/kg, iv administered 2 and 12 hrs post infection measured 24 hrs post treatment | 2012 | Journal of medicinal chemistry, Jan-26, Volume: 55, Issue:2 | Fluorocyclines. 2. Optimization of the C-9 side-chain for antibacterial activity and oral efficacy. |
| AID68391 | In vitro antibacterial activity against vancomycin-resistant Enterococcus faecium 2164 (VRE.3) | 2003 | Bioorganic & medicinal chemistry letters, Nov-17, Volume: 13, Issue:22 | Synthesis and in vitro activity of novel isoxazolyl tetrahydropyridinyl oxazolidinone antibacterial agents. |
| AID244998 | Antibacterial activity against Enterococcus faecalis ATCC 19433 was determined | 2004 | Bioorganic & medicinal chemistry letters, Oct-18, Volume: 14, Issue:20 | Synthesis and antibacterial activity of novel 6-fluoro-1-[(1R,2S)-2-fluorocyclopropan-1-yl]-4-oxoquinoline-3-carboxylic acids bearing cyclopropane-fused 2-amino-8-azabicyclo[4.3.0]nonan-8-yl substituents at the C-7 position. |
| AID410204 | Antibacterial activity against methicillin-resistant Staphylococcus epidermidis by broth micro dilution method | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24 | A facile synthesis, antibacterial, and antitubercular studies of some piperidin-4-one and tetrahydropyridine derivatives. |
| AID552859 | Antibacterial activity against Enterococcus faecalis infected in po dosed in vivo acute model administered bid for 1 day | 2011 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1 | The discovery and structure-activity relationships leading to CE-156811, a difluorophenyl cyclopropyl fluoroether: a novel potent antibacterial analog derived from hygromycin A. |
| AID734709 | Antibacterial activity against Bacillus subtilis MTCC 121 after 24 hrs by agar dilution method | 2013 | European journal of medicinal chemistry, Apr, Volume: 62 | Synthesis, biological evaluation of new oxazolidino-sulfonamides as potential antimicrobial agents. |
| AID576897 | Ratio of Cmax to MIC for 12.5 hrs peripheral compartment culture samples of Enterococcus faecalis Ef1497 MutM3 in two-compartment pharmacokinetic/pharmacodynamic model at 600 mg, bid administered as 0.5 hr infusion for 2 days | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID1407933 | Antibacterial activity against methicillin-resistant Staphylococcus aureus USA100 after 24 hrs by broth microdilution method | 2018 | European journal of medicinal chemistry, Sep-05, Volume: 157 | Discovery of dual GyrB/ParE inhibitors active against Gram-negative bacteria. |
| AID558531 | Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus 555 measured on day 35 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID645032 | Antibacterial activity against Streptococcus pyogenes ATCC 19615 after 16 to 20 hrs by microbroth dilution method | 2012 | European journal of medicinal chemistry, Apr, Volume: 50 | Synthesis and preliminary antibacterial evaluation of Linezolid-like 1,2,4-oxadiazole derivatives. |
| AID525126 | Suppression of drug resistance development in LZD intermediate-resistant Staphylococcus aureus KM183 assessed as prolonged length of subculture to develop Linezolid resistance at 4 times MIC and 0.25 times IC50 after 8 days | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Delayed development of linezolid resistance in Staphylococcus aureus following exposure to low levels of antimicrobial agents. |
| AID542908 | Antimicrobial activity against Bacillus anthracis infected in in vitro hollow fiber PK/PD model assessed as prevention of bacterial regrowth at 700 mg administered once every 24 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID1877891 | Antibacterial activity against Escherichia coli K12 harbouring TolC-deficient mutant assessed as bacterial growth inhibition | 2022 | Bioorganic & medicinal chemistry letters, 03-01, Volume: 59 | Novel 2,4-disubstituted quinazoline analogs as antibacterial agents with improved cytotoxicity profile: Modification of the benzenoid part. |
| AID1168025 | Antibacterial activity against vancomycin-resistant Enterococcus faecium clinical isolate 6/22 after overnight incubation by two-fold serial dilution method | 2014 | Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21 | Synthesis and biological evaluation of novel peptide BF2 as an antibacterial agent against clinical isolates of vancomycin-resistant enterococci. |
| AID1312946 | Bactericidal activity against methicillin-resistant Staphylococcus aureus NRS119 clinical isolate after 20 hrs by broth microdilution method | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10 | Second-Generation Phenylthiazole Antibiotics with Enhanced Pharmacokinetic Properties. |
| AID388043 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus MB2865 after 18 to 20 hrs by serial dilution method | 2008 | Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19 | Isolation, structure, and antibacterial activity of thiazomycin A, a potent thiazolyl peptide antibiotic from Amycolatopsis fastidiosa. |
| AID483194 | Antibacterial activity against Staphylococcus epidermidis ATCC 12228 by microbroth dilution technique | 2010 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 20, Issue:12 | Design, synthesis, and antibacterial activity of 2,5-dihydropyrrole formyl hydroxyamino derivatives as novel peptide deformylase inhibitors. |
| AID1390460 | Antibacterial activity against Enterococcus faecium 575 | 2018 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 28, Issue:7 | Design, synthesis and biological evaluation of spiropyrimidinetriones oxazolidinone derivatives as antibacterial agents. |
| AID1151737 | Antibacterial activity against linezolid-resistant Staphylococcus aureus isolate 4184 | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID206727 | In vitro antibacterial activity against the methicillin-resistant Staphylococcus aureus 88 | 1999 | Bioorganic & medicinal chemistry letters, Sep-20, Volume: 9, Issue:18 | 3D QSAR studies on new oxazolidinone antibacterial agents by comparative molecular field analysis. |
| AID297120 | Antibacterial activity against vancomycin-resistant Staphylococcus aureus 70 after 18 hrs by agar plate dilution method | 2007 | Journal of medicinal chemistry, Aug-23, Volume: 50, Issue:17 | Discovery of 1,4-dihydroxy-2-naphthoate [corrected] prenyltransferase inhibitors: new drug leads for multidrug-resistant gram-positive pathogens. |
| AID1312948 | Bactericidal activity against methicillin-resistant Staphylococcus aureus USA100 NRS382 clinical isolate after 20 hrs by broth microdilution method | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10 | Second-Generation Phenylthiazole Antibiotics with Enhanced Pharmacokinetic Properties. |
| AID390336 | Antimicrobial activity against extended spectrum beta-lactamase producing Escherichia coli 2269 | 2008 | Journal of natural products, Dec, Volume: 71, Issue:12 | Citreamicins with potent gram-positive activity. |
| AID1361123 | Bacteriostatic activity against Escherichia coli BW25113 after 20 hrs by broth microdilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | N-(1,3,4-oxadiazol-2-yl)benzamide analogs, bacteriostatic agents against methicillin- and vancomycin-resistant bacteria. |
| AID535260 | Antimicrobial activity against vancomycin resistant Staphylococcus aureus VRS-8 expressing SCCmec element by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | In vitro activity of ceftaroline against community-associated methicillin-resistant, vancomycin-intermediate, vancomycin-resistant, and daptomycin-nonsusceptible Staphylococcus aureus isolates. |
| AID1563584 | Inhibition of FabB/FabF in Staphylococcus aureus ATCC 29213 assessed as antibacterial activity after 16 hrs by agar dilution method | 2019 | Journal of medicinal chemistry, 07-25, Volume: 62, Issue:14 | Late-Stage Functionalization of Platensimycin Leading to Multiple Analogues with Improved Antibacterial Activity in Vitro and in Vivo. |
| AID1609284 | Antibacterial activity against methicilline-resistant Staphylococcus aureus NRS386 USA700 after 18 to 20 hrs by CLSI-based broth microdilution assay | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Phenylthiazoles with nitrogenous side chain: An approach to overcome molecular obesity. |
| AID206450 | In vitro antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) C6068. | 1999 | Bioorganic & medicinal chemistry letters, Sep-20, Volume: 9, Issue:18 | Synthesis and in vitro activity of new oxazolidinone antibacterial agents having substituted isoxazoles. |
| AID319162 | Protein binding in human plasma | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7 | Linezolid (ZYVOX), the first member of a completely new class of antibacterial agents for treatment of serious gram-positive infections. |
| AID1852685 | Antibacterial activity against recombinant OM pore producing Pseudomonas aeruginosa assessed as inhibition of bacterial growth | |||
| AID1770351 | Antibacterial activity against Vancomycin-susceptible Enterococcus faecium ATCC 19434 assessed as inhibition of bacterial growth measured after 20 hrs by two-fold microdilution assay | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Modification of 5-methylphenanthridium from benzothiazoles to indoles as potent FtsZ inhibitors: Broadening the antibacterial spectrum toward vancomycin-resistant enterococci. |
| AID520765 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus infected in New Zealand rabbit osteomyelitis model assessed as improvement in rate of bone reconstruction at 60 mg/kg, po administered every 8 hrs for 4 weeks measured on week 6 po | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Efficacies of ceftobiprole medocaril and comparators in a rabbit model of osteomyelitis due to methicillin-resistant Staphylococcus aureus. |
| AID370014 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus Smith infected in C3H mouse assessed as reduction in log number of CFU at 3.12 mg/kg/day, po administered within 15 mins of infection measured after 48 hrs by organ burden assay | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vivo efficacy of a novel oxazolidinone compound in two mouse models of infection. |
| AID1393953 | Antibacterial activity against methicillin resistant Staphylococcus aureus BAA-44 after 16 to 20 hrs by CLSI method | 2018 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 28, Issue:16 | 3-Hydroxy-1,5-dihydro-2H-pyrrol-2-ones as novel antibacterial scaffolds against methicillin-resistant Staphylococcus aureus. |
| AID1770368 | Ratio of MBC to MIC against Vancomycin-susceptible Enterococcus faecalis ATCC 29212 | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Modification of 5-methylphenanthridium from benzothiazoles to indoles as potent FtsZ inhibitors: Broadening the antibacterial spectrum toward vancomycin-resistant enterococci. |
| AID285031 | Antimicrobial activity against Rothia mucilaginosa at 0.12 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID517668 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus 92-1191 by standard serial-dilution technique | 2010 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 20, Issue:20 | Bottromycin derivatives: efficient chemical modifications of the ester moiety and evaluation of anti-MRSA and anti-VRE activities. |
| AID534509 | Drug level in human THP1 cells at 50 mg/L after 30 mins at pH 6 | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Cellular pharmacokinetics of the novel biaryloxazolidinone radezolid in phagocytic cells: studies with macrophages and polymorphonuclear neutrophils. |
| AID1609277 | Bactericidal activity against methicilline-resistant Staphylococcus aureus NRS-119 incubated for 18 to 20 hrs followed by replating on tryptic soy agar plate and further incubated for 18 to 24 hrs by CLSI-based broth microdilution assay | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Phenylthiazoles with nitrogenous side chain: An approach to overcome molecular obesity. |
| AID1704212 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus ATCC 25923 incubated for 18 hrs | 2020 | European journal of medicinal chemistry, Nov-15, Volume: 206 | 1,2,3-Triazole-containing hybrids with potential antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA). |
| AID283617 | Antimicrobial activity against Enterococcus faecium 44 with heterozygous 23S rRNA G2576U mutation | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | In vitro activity of the oxazolidinone RWJ-416457 against linezolid-resistant and -susceptible staphylococci and enterococci. |
| AID1692902 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus | 2021 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 32 | Design, synthesis and antibacterial evaluation of novel oxazolidinone derivatives nitrogen-containing fused heterocyclic moiety. |
| AID285161 | Antimicrobial activity against non replicating persistence Mycobacterium tuberculosis H37Rv in anaerobic condition assessed as relative light unit after 11 days by LORA assay | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Low-oxygen-recovery assay for high-throughput screening of compounds against nonreplicating Mycobacterium tuberculosis. |
| AID577091 | Ratio of AUC (0 to 24 hrs) to MIC for Enterococcus faecalis Ef1497 in two-compartment pharmacokinetic/pharmacodynamic model at 800 mg, bid administered as 0.5 hr infusion for 2 days | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID583391 | Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus isolate NJ992 assessed as bacterial count at 4 times MIC after 24 hrs by colony counting method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | In vitro activity of the new multivalent glycopeptide-cephalosporin antibiotic TD-1792 against vancomycin-nonsusceptible Staphylococcus isolates. |
| AID287262 | Antimicrobial activity against Streptococcus pneumoniae by agar dilution method | 2007 | European journal of medicinal chemistry, Feb, Volume: 42, Issue:2 | Structure-antibacterial activity of arylcarbonyl- and arylsulfonyl-piperazine 5-triazolylmethyl oxazolidinones. |
| AID283384 | Decrease in mitochondrial Cytochrome C oxidase 2 protein expression in PBMCs from patient on a long-term schedule of the drug with hyperlactatemia relative to control | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Reversible inhibition of mitochondrial protein synthesis during linezolid-related hyperlactatemia. |
| AID583893 | Antibacterial activity against vancomycin-intermediate Staphylococcus aureus isolate 435 by broth microdilution assay | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Comparative efficacies of human simulated exposures of telavancin and vancomycin against methicillin-resistant Staphylococcus aureus with a range of vancomycin MICs in a murine pneumonia model. |
| AID532799 | Antibacterial activity against vancomycin-intermediate Staphylococcus aureus Mu50 after 24 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Improved antimicrobial activity of linezolid against vancomycin-intermediate Staphylococcus aureus. |
| AID285066 | Antimicrobial activity against beta hemolytic Streptococci group G at 0.12 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID303968 | Bactericidal activity against Streptococcus pneumoniae after 48 hrs by time kill study | 2007 | Journal of medicinal chemistry, Nov-29, Volume: 50, Issue:24 | Antibacterial oxazolidinones possessing a novel C-5 side chain. (5R)-trans-3-[3-Fluoro-4- (1-oxotetrahydrothiopyran-4-yl)phenyl]-2- oxooxazolidine-5-carboxylic acid amide (PF-00422602), a new lead compound. |
| AID1680041 | Antibacterial activity against NDM1 producing carbapenem-resistant Enterobacteriaceae clinical isolate 5 assessed as reduction in bacterial growth incubated for 16 to 20 hrs by CLSI-based broth microdilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Synthesis and antibacterial bioactivities of cationic deacetyl linezolid amphiphiles. |
| AID278923 | Antibacterial activity against macrolide-resistant Streptococcus pneumoniae | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | In vitro antibacterial activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. |
| AID567452 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus CGK4 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Development of daptomycin nonsusceptibility with heterogeneous vancomycin-intermediate resistance and oxacillin susceptibility in methicillin-resistant Staphylococcus aureus during high-dose daptomycin treatment. |
| AID285131 | Antimicrobial activity against viridans group Streptococcus sanguinis at 0.12 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID477375 | Antibacterial activity against Klebsiella pneumoniae ATCC 27736 after 24 hrs | 2009 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13 | Synthesis and antibacterial evaluation of isoxazolinyl oxazolidinones: Search for potent antibacterial. |
| AID576653 | Bactericidal activity against 13 hrs peripheral compartment culture samples of Enterococcus faecalis ATCC 29212 in two-compartment pharmacokinetic/pharmacodynamic model assessed as effect on bacterial count at 200 mg, bid administered as 0.5 hr infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID560363 | Antimicrobial activity against vancomycin-resistant Enterococcus faecium ATCC 51559 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Impact of human serum albumin on oritavancin in vitro activity against enterococci. |
| AID1504625 | Antibacterial activity against Staphylococcus epidermidis ATCC 14990 by microbroth dilution method | 2017 | ACS medicinal chemistry letters, Nov-09, Volume: 8, Issue:11 | Design, Synthesis, and Antibacterial Evaluation of Oxazolidinones with Fused Heterocyclic C-Ring Substructure. |
| AID523817 | Antimicrobial activity against oxacillin-susceptible coagulase-negative Staphylococcus aureus assessed as inhibition of microbial growth at 2 ug/ml by CLSI method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative activities of TR-700 (torezolid) against staphylococcal blood isolates collected in Spain. |
| AID285016 | Antimicrobial activity against Enterococcus raffinosus at 0.5 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID522922 | Antibacterial activity against community-acquired methicillin-resistant panton-valentine leukocidin-positive Staphylococcus aureus isolate 1471 after 24 hrs by modified broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Antistaphylococcal activity of ACHN-490 tested alone and in combination with other agents by time-kill assay. |
| AID1151741 | Antibacterial activity against Staphylococcus aureus measured after 3 serial passages | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID1327110 | Antibacterial activity against Pseudomonas aeruginosa NCIM 2036 at 3 ug/ml measured after 8 hrs by spectrophotometric method | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Design, synthesis and biological evaluation of novel azaspiro analogs of linezolid as antibacterial and antitubercular agents. |
| AID575160 | Inhibition of acrAB AcrAB-TolC-mediated Nile Red efflux in Escherichia coli K-12 3-AG100 overexpressing acrAB AcrAB-TolC assessed as time needed for 50% efflux after energization with 50 mM glucose upto 2 mM by spectrofluorometric assay | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Optimized Nile Red efflux assay of AcrAB-TolC multidrug efflux system shows competition between substrates. |
| AID565502 | Plasma protein binding in human | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro bactericidal activity of iclaprim in human plasma. |
| AID734686 | Antibacterial activity against Pseudomonas aeruginosa MTCC 2453 at 20 ug/ml after 24 hrs by disk diffusion method | 2013 | European journal of medicinal chemistry, Apr, Volume: 62 | Synthesis, biological evaluation of new oxazolidino-sulfonamides as potential antimicrobial agents. |
| AID576883 | Ratio of Cmax to MIC for 12.5 hrs peripheral compartment culture samples of Staphylococcus aureus RN4220 in two-compartment pharmacokinetic/pharmacodynamic model at 600 mg, bid administered as 0.5 hr infusion for 2 days | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID375354 | Antibacterial activity against Staphylococcus aureus infected iv bid dosed mouse model assessed as reduction of colony forming unit in kidney | 2009 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13 | Nocathiacin analogs: Synthesis and antibacterial activity of novel water-soluble amides. |
| AID548475 | Antibacterial activity against vancomycin-susceptible Staphylococcus aureus Mu50omega expressing vraSm, graRm mutant gene after 48 hrs by Etest | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Contribution of vraSR and graSR point mutations to vancomycin resistance in vancomycin-intermediate Staphylococcus aureus. |
| AID1271228 | Antibacterial activity against clinical isolate Neisseria meningitidis M-1 by microbroth dilution method | 2015 | ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11 | Design, Synthesis, and Identification of Silicon Incorporated Oxazolidinone Antibiotics with Improved Brain Exposure. |
| AID1603256 | Antibacterial activity against RMP-resistant Mycobacterium tuberculosis after 7 days by microplate alamar blue assay | |||
| AID1723515 | Bacteriostatic activity against Enterococcus faecium ATCC 700221 assessed as reduction in bacterial burden at 5 times MIC preincubated for 24 hrs followed by replating on soya agar plates and measured after 16 hrs by time-kill assay | |||
| AID533420 | Antimicrobial activity against Micromonas micros assessed as resistant isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activities of doripenem, a new broad-spectrum carbapenem, against recently collected clinical anaerobic isolates, with emphasis on the Bacteroides fragilis group. |
| AID66896 | Antibacterial activity against Enterococcus faecalis (ATCC 29212) | 2001 | Bioorganic & medicinal chemistry letters, Jul-23, Volume: 11, Issue:14 | Novel piperidinyloxy oxazolidinone antimicrobial agents. |
| AID405632 | Drug level at steady state in human serum at 600 mg administered every 12 hrs | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Comparative study of the effects of pyridoxine, rifampin, and renal function on hematological adverse events induced by linezolid. |
| AID533753 | Antimicrobial activity against linezolid resistant methicillin-susceptible Staphylococcus aureus SA040L after 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Cellular pharmacodynamics of the novel biaryloxazolidinone radezolid: studies with infected phagocytic and nonphagocytic cells, using Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Legionella pneumophila. |
| AID541065 | Half life in cage fluid of Albino guiena pig at 75 mg/kg, ip | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Linezolid alone or combined with rifampin against methicillin-resistant Staphylococcus aureus in experimental foreign-body infection. |
| AID548523 | Antimicrobial activity against Vancomycin-susceptible Enterococcus faecium assessed as percent resistant isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Activities of dalbavancin against a worldwide collection of 81,673 gram-positive bacterial isolates. |
| AID68563 | Minimum inhibitory concentration measured against Enterococcus faecium | 2002 | Bioorganic & medicinal chemistry letters, Aug-19, Volume: 12, Issue:16 | The synthesis and biological evaluation of a novel series of antimicrobials of the oxazolidinone class. |
| AID1680068 | Antibacterial activity against Enterococcus faecalis ATCC 29212 assessed as reduction in bacterial growth incubated 16 to 20 hrs by CLSI-based broth microdilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Synthesis and antibacterial bioactivities of cationic deacetyl linezolid amphiphiles. |
| AID1519041 | Antibacterial activity against clinical isolates of methicillin-sensitive Staphylococcus aureus assessed as reduction in bacterial cell growth by CLSI protocol based broth microdilution method | 2020 | European journal of medicinal chemistry, Jan-01, Volume: 185 | Optimization of biaryloxazolidinone as promising antibacterial agents against antibiotic-susceptible and antibiotic-resistant gram-positive bacteria. |
| AID1395678 | Antibacterial activity against methicillin-resistant Staphylococcus aureus NRS385 after 18 hrs by broth microdilution assay | 2018 | European journal of medicinal chemistry, May-10, Volume: 151 | Phenylthiazoles with tert-Butyl side chain: Metabolically stable with anti-biofilm activity. |
| AID1770344 | Antibacterial activity against penicillin-susceptible Pseudomonas aeruginosa ATCC 27853 assessed as inhibition of bacterial growth measured after 20 hrs by two-fold microdilution assay | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Modification of 5-methylphenanthridium from benzothiazoles to indoles as potent FtsZ inhibitors: Broadening the antibacterial spectrum toward vancomycin-resistant enterococci. |
| AID1888847 | Antibacterial activity against Staphylococcus aureus 1199 measured after 24 hrs by Muller Hinton broth based MTT assay | 2022 | Bioorganic & medicinal chemistry, 01-15, Volume: 54 | Potentiating the intracellular killing of Staphylococcus aureus by dihydroquinazoline analogues as NorA efflux pump inhibitor. |
| AID1390461 | Antibacterial activity against PVL positive Staphylococcus aureus | 2018 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 28, Issue:7 | Design, synthesis and biological evaluation of spiropyrimidinetriones oxazolidinone derivatives as antibacterial agents. |
| AID573154 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis assessed as resistant isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID293554 | Antibacterial activity against Bacillus subtilis MTCC 121 after 24 hrs by agar dilution assay | 2007 | European journal of medicinal chemistry, Jun, Volume: 42, Issue:6 | Organoiodine(III) mediated synthesis of 3,9-diaryl- and 3,9-difuryl-bis-1,2,4-triazolo[4,3-a][4,3-c]pyrimidines as antibacterial agents. |
| AID523292 | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv infected in B6 mouse assessed as 2 log reduction in bacterial burden in lungs orally treated in water-1% methylcellulose upto 8 days | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Fast standardized therapeutic-efficacy assay for drug discovery against tuberculosis. |
| AID1687309 | Synergistic antibacterial activity against Escherichia coli ATCC 25922 in presence of 0.25 times MIC of colistin incubated for 18 to 20 hrs by broth microdilution method | 2020 | European journal of medicinal chemistry, Jan-15, Volume: 186 | Development of benzimidazole-based derivatives as antimicrobial agents and their synergistic effect with colistin against gram-negative bacteria. |
| AID67400 | In vitro antibacterial activity against Enterococcus faecalis strain ATCC 29212 | 1996 | Journal of medicinal chemistry, Feb-02, Volume: 39, Issue:3 | Synthesis and antibacterial activity of U-100592 and U-100766, two oxazolidinone antibacterial agents for the potential treatment of multidrug-resistant gram-positive bacterial infections. |
| AID1704255 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 33591 measured after 18 hrs by CLSI-based broth microdilution method | 2020 | European journal of medicinal chemistry, Nov-15, Volume: 206 | 1,2,3-Triazole-containing hybrids with potential antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA). |
| AID530050 | Antimicrobial activity against Staphylococcus aureus 286607-R1 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Discovery and characterization of QPT-1, the progenitor of a new class of bacterial topoisomerase inhibitors. |
| AID284956 | Antimicrobial activity against Bacillus cereus at 2 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID303912 | Antibacterial activity against methicillin-resistant Staphylococcus aureus 562 after 24 hrs by agar dilution method | 2007 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 17, Issue:24 | Synthesis and antibacterial activity of potent heterocyclic oxazolidinones and the identification of RBx 8700. |
| AID535022 | Antimicrobial activity against vancomycin intermediate Staphylococcus aureus NRS-19 expressing SCCmec type 2 element by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | In vitro activity of ceftaroline against community-associated methicillin-resistant, vancomycin-intermediate, vancomycin-resistant, and daptomycin-nonsusceptible Staphylococcus aureus isolates. |
| AID1710587 | Antibacterial activity against cephalosporin-resistant Streptococcus pneumoniae ATCC 51916 assessed as inhibition of visible bacterial growth incubated for 18 to 20 hrs by CLSI method | 2020 | RSC medicinal chemistry, Jan-01, Volume: 11, Issue:1 | Potent trifluoromethoxy, trifluoromethylsulfonyl, trifluoromethylthio and pentafluorosulfanyl containing (1,3,4-oxadiazol-2-yl)benzamides against drug-resistant Gram-positive bacteria. |
| AID352926 | Antibacterial activity against Streptococcus pyogenes ATCC 8736 after 18 to 20 hrs by agar dilution method | 2009 | Bioorganic & medicinal chemistry letters, May-01, Volume: 19, Issue:9 | Synthesis and antibacterial activities of novel oxazolidinones having spiro[2,4]heptane moieties. |
| AID283631 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus B2 with heterozygous 23S rRNA G2576U mutation | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | In vitro activity of the oxazolidinone RWJ-416457 against linezolid-resistant and -susceptible staphylococci and enterococci. |
| AID475010 | Antibacterial activity against Haemophilus influenzae LCB0015 by two fold serial dilution method | 2010 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 20, Issue:7 | Synthesis, crystal and antibacterial studies of diversely functionalized tetrahydropyridin-4-ol. |
| AID531640 | Antimicrobial activity against linezolid-,erythromycin-resistant Staphylococcus aureus A7820 with G2576U mutation at 23s rRNA | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | R chi-01, a new family of oxazolidinones that overcome ribosome-based linezolid resistance. |
| AID390326 | Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus 2012 | 2008 | Journal of natural products, Dec, Volume: 71, Issue:12 | Citreamicins with potent gram-positive activity. |
| AID409578 | Antimicrobial activity against Staphylococcus aureus ATCC 29213 after 16 to 18 hrs by agar dilution method | 2008 | European journal of medicinal chemistry, Aug, Volume: 43, Issue:8 | Synthesis and biological evaluation of new N-linked 5-triazolylmethyl oxazolidinones. |
| AID284940 | Antimicrobial activity against Aerococcus spp. at 0.12 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID573135 | Antibacterial activity against erythromycin-nonsusceptible Streptococcus pyogenes assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID560518 | Antimicrobial activity against SCCmec type III vancomycin-intermediate Staphylococcus aureus isolate 15b52 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID285346 | Antibacterial activity against Staphylococcus aureus LUG855 in CCY media | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Effect of antibiotics on Staphylococcus aureus producing Panton-Valentine leukocidin. |
| AID542900 | fT>MIC in Bacillus anthracis infected in vitro hollow fiber PK/PD model at simulated dose of 500 mg administered every 12 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID405630 | Toxicity in rabbit heart mitochondria assessed as inhibition of mitochondrial protein synthesis | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Comparative study of the effects of pyridoxine, rifampin, and renal function on hematological adverse events induced by linezolid. |
| AID576867 | Bactericidal activity against 12 hrs peripheral compartment culture samples of Enterococcus faecalis Ef1497 MutM3 in two-compartment pharmacokinetic/pharmacodynamic model assessed as effect on bacterial count at 200 mg, bid administered as 0.5 hr infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID1721020 | Antitubercular activity against linezolid-resistant Mycobacterium tuberculosis incubated for 7 days by microplate alamar blue assay | 2020 | Journal of medicinal chemistry, 09-10, Volume: 63, Issue:17 | Discovery of a Conformationally Constrained Oxazolidinone with Improved Safety and Efficacy Profiles for the Treatment of Multidrug-Resistant Tuberculosis. |
| AID209463 | In vitro antibacterial activity against Streptococcus pyogenes ATCC 8668 (S.p.1). | 1999 | Bioorganic & medicinal chemistry letters, Sep-20, Volume: 9, Issue:18 | Synthesis and in vitro activity of new oxazolidinone antibacterial agents having substituted isoxazoles. |
| AID1393957 | Antibacterial activity against methicillin resistant Staphylococcus aureus NR 45898 after 16 to 20 hrs by CLSI method | 2018 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 28, Issue:16 | 3-Hydroxy-1,5-dihydro-2H-pyrrol-2-ones as novel antibacterial scaffolds against methicillin-resistant Staphylococcus aureus. |
| AID206228 | In vitro antibacterial activity against Staphylococcus epidermis strain UC 30031 | 1996 | Journal of medicinal chemistry, Feb-02, Volume: 39, Issue:3 | Synthesis and antibacterial activity of U-100592 and U-100766, two oxazolidinone antibacterial agents for the potential treatment of multidrug-resistant gram-positive bacterial infections. |
| AID576663 | Bactericidal activity against 14 hrs peripheral compartment culture samples of Enterococcus faecalis ATCC 29212 in two-compartment pharmacokinetic/pharmacodynamic model assessed as effect on bacterial count at 600 mg, bid administered as 0.5 hr infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID532804 | Antibacterial activity against vancomycin-susceptible Staphylococcus aureus 99/3700-W after 24 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Improved antimicrobial activity of linezolid against vancomycin-intermediate Staphylococcus aureus. |
| AID1352003 | Antibacterial activity against methicillin/linezolid-resistant Staphylococcus aureus NRS271 infected in BALB/c mouse assessed as decrease in bacterial survival in mouse liver at 0.4 mg, ip bid administered 4.5 days measured after 90 hrs | 2018 | European journal of medicinal chemistry, Feb-10, Volume: 145 | Discovery of novel piperonyl derivatives as diapophytoene desaturase inhibitors for the treatment of methicillin-, vancomycin- and linezolid-resistant Staphylococcus aureus infections. |
| AID283391 | Antimicrobial activity against Nocardia farcinica after 72 hrs by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | In vitro activities of tigecycline and eight other antimicrobials against different Nocardia species identified by molecular methods. |
| AID520028 | Antimicrobial activity against Enterococcus faecium A6345 | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID542883 | fAUC (24 hrs) in Bacillus anthracis infected in vitro hollow fiber PK/PD model at simulated dose of 800 mg administered once every 24 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID559363 | Antimicrobial activity against compound-susceptible Coxiella burnetii Q212 obtained from patient with acute Q fever infected in african green monkey Vero cells after 24 hrs by shell vial assay | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Bacteriostatic and bactericidal activities of tigecycline against Coxiella burnetii and comparison with those of six other antibiotics. |
| AID1861525 | Cmax in Wistar rat at 15 mg/kg, iv | 2022 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 71 | WCK 4034: A promising oxazolidinone for treating gram positive infections. |
| AID1514448 | Antitubercular activity against rifampicin-resistant Mycobacterium tuberculosis after 7 days by resazurin dye based colorimetric assay | 2019 | Bioorganic & medicinal chemistry letters, 01-01, Volume: 29, Issue:1 | Synthesis, antituberculosis studies and biological evaluation of new quinoline derivatives carrying 1,2,4-oxadiazole moiety. |
| AID323813 | Reduction in bioluminescent methicillin-resistant Staphylococcus aureus Xen1 in neutropenic CD1 mouse with peritonitis at 100 mg/kg, po after 3 hrs relative to control | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Rapid bactericidal activity of daptomycin against methicillin-resistant and methicillin-susceptible Staphylococcus aureus peritonitis in mice as measured with bioluminescent bacteria. |
| AID560365 | Antimicrobial activity against vancomycin-resistant Enterococcus faecalis 1058946 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Impact of human serum albumin on oritavancin in vitro activity against enterococci. |
| AID564092 | Antimicrobial activity against log-phase methicillin-resistant Staphylococcus aureus HUSA 304 by M7-A6 method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | Efficacy of high doses of daptomycin versus alternative therapies against experimental foreign-body infection by methicillin-resistant Staphylococcus aureus. |
| AID576888 | Ratio of Cmax to MIC for 0.5 hrs peripheral compartment culture samples of Enterococcus faecalis ATCC 29212 in two-compartment pharmacokinetic/pharmacodynamic model at 600 mg, bid administered as 0.5 hr infusion for 2 days | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID1680055 | Antibacterial activity against methicillin-resistant Staphylococcus aureus clinical isolate 10 assessed as reduction in bacterial growth incubated for 16 to 20 hrs by CLSI-based broth microdilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Synthesis and antibacterial bioactivities of cationic deacetyl linezolid amphiphiles. |
| AID285045 | Antimicrobial activity against Enterococcus casseliflavus by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID1190641 | Antibacterial activity against Pseudomonas aeruginosa NCIM-2036 incubated for 24 hrs by two fold serial dilution method | 2015 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 25, Issue:4 | Biofilm inhibition of linezolid-like Schiff bases: synthesis, biological activity, molecular docking and in silico ADME prediction. |
| AID577098 | T>MIC in Enterococcus faecalis Ef1497 in two-compartment pharmacokinetic/pharmacodynamic model at 600 mg, bid administered as 0.5 hr infusion for 2 days | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID1395708 | Bactericidal activity against methicillin-resistant Staphylococcus aureus NRS385 incubated fo 18 hrs followed by re-plating on tryptic soy agar plates at 37 degC for 18 hrs by broth microdilution assay | 2018 | European journal of medicinal chemistry, May-10, Volume: 151 | Phenylthiazoles with tert-Butyl side chain: Metabolically stable with anti-biofilm activity. |
| AID763983 | Antibacterial activity against vancomycin-susceptible Enterococcus after 18 hrs by NCCLS agar dilution method | 2013 | European journal of medicinal chemistry, Aug, Volume: 66 | Synthesis and antibacterial activities of N-substituted-glycinyl 1H-1,2,3-triazolyl oxazolidinones. |
| AID1327112 | Antibacterial activity against Staphylococcus aureus NCIM 2079 at 10 ug/ml measured after 12 hrs by spectrophotometric method | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Design, synthesis and biological evaluation of novel azaspiro analogs of linezolid as antibacterial and antitubercular agents. |
| AID531639 | Antimicrobial activity against Staphylococcus aureus ATCC 29213 | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | R chi-01, a new family of oxazolidinones that overcome ribosome-based linezolid resistance. |
| AID207025 | Antibacterial activity against methicillin susceptible Staphylococcus aureus (OC 4172) in broth (without serum) | 2001 | Bioorganic & medicinal chemistry letters, Jul-23, Volume: 11, Issue:14 | Novel piperidinyloxy oxazolidinone antimicrobial agents. |
| AID1303407 | Antibacterial activity against Pseudomonas aeruginosa after 24 hrs by microdilution method | 2016 | Bioorganic & medicinal chemistry letters, 07-01, Volume: 26, Issue:13 | Identification of novel aminopiperidine derivatives for antibacterial activity against Gram-positive bacteria. |
| AID262234 | Antibacterial activity against linezolid-resistant Staphylococcus aureus NRS 119 | 2006 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 16, Issue:6 | Novel 4-N-substituted aryl pent-2-ene-1,4-dione derivatives of piperazinyloxazolidinones as antibacterials. |
| AID1151750 | Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate 0612 | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID1770350 | Antibacterial activity against Vancomycin-susceptible Enterococcus faecalis ATCC 29212 assessed as inhibition of bacterial growth measured after 20 hrs by two-fold microdilution assay | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Modification of 5-methylphenanthridium from benzothiazoles to indoles as potent FtsZ inhibitors: Broadening the antibacterial spectrum toward vancomycin-resistant enterococci. |
| AID562592 | Antimicrobial activity against Enterococcus faecalis expressing VanB gene clinical isolates assessed as resistant isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID532787 | Antibacterial activity against vancomycin-intermediate Staphylococcus aureus BR3 after 24 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Improved antimicrobial activity of linezolid against vancomycin-intermediate Staphylococcus aureus. |
| AID574554 | Decrease in PSMbeta1 levels in Staphylococcus aureus USA300 at subinhibitory concentration after 24 hrs by RP-HPLC/ESI-MS | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Subinhibitory concentrations of protein synthesis-inhibiting antibiotics promote increased expression of the agr virulence regulator and production of phenol-soluble modulin cytolysins in community-associated methicillin-resistant Staphylococcus aureus. |
| AID283640 | Antimicrobial activity against Staphylococcus aureus ST/02/2121 with 23S rRNA G2447T mutation | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | In vitro activity of the oxazolidinone RWJ-416457 against linezolid-resistant and -susceptible staphylococci and enterococci. |
| AID348865 | Antibacterial activity against vancomycin-resistant Enterococcus 6 after 18 to 20 hrs by agar dilution method | 2008 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 18, Issue:21 | Synthesis and antibacterial activities of novel oxazolidinones having cyclic sulfonamide moieties. |
| AID530128 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus ATCC 29213 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Pharmacodynamic characterization of ceftobiprole in experimental pneumonia caused by phenotypically diverse Staphylococcus aureus strains. |
| AID1139120 | Dose normalized AUC in rat at 2.8 to 9.5 mg/kg, iv | 2014 | Bioorganic & medicinal chemistry letters, May-01, Volume: 24, Issue:9 | Successful application of serum shift prediction models to the design of dual targeting inhibitors of bacterial gyrase B and topoisomerase IV with improved in vivo efficacy. |
| AID520027 | Antimicrobial activity against Enterococcus faecium A5960 | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID1547712 | Antibacterial activity against Staphylococcus haemolyticus ATCC 29970 by broth microdilution method | 2020 | ACS medicinal chemistry letters, Mar-12, Volume: 11, Issue:3 | Structure-Activity Relationship for the Oxadiazole Class of Antibacterials. |
| AID244877 | Antibacterial activity against Escherichia coli NIHJ was determined | 2004 | Bioorganic & medicinal chemistry letters, Oct-18, Volume: 14, Issue:20 | Synthesis and antibacterial activity of novel 6-fluoro-1-[(1R,2S)-2-fluorocyclopropan-1-yl]-4-oxoquinoline-3-carboxylic acids bearing cyclopropane-fused 2-amino-8-azabicyclo[4.3.0]nonan-8-yl substituents at the C-7 position. |
| AID562173 | Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus 555 after 50 passages by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID574069 | Antibacterial activity against community-associated methicillin-resistant Staphylococcus aureus OC8525 infected in SKH1 mouse assessed as log reduction in CFU/g skin at 5 mg/kg/day, sc administered post infection measured after 48 hrs | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | In vivo activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. |
| AID409584 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus 05-2 infected in iv dosed KunMing SPF mouse | 2008 | European journal of medicinal chemistry, Aug, Volume: 43, Issue:8 | Synthesis and biological evaluation of new N-linked 5-triazolylmethyl oxazolidinones. |
| AID285093 | Antimicrobial activity against viridans group Streptococcus gordonii at 1 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID499160 | Protein binding in mouse plasma | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vivo activity of ceftobiprole in murine skin infections due to Staphylococcus aureus and Pseudomonas aeruginosa. |
| AID572274 | Antimicrobial activity against multiple drug-resistant Streptococcus pneumoniae ATCC 700677 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vivo characterization of the peptide deformylase inhibitor LBM415 in murine infection models. |
| AID283638 | Antimicrobial activity against Staphylococcus aureus ST/02/2121 | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | In vitro activity of the oxazolidinone RWJ-416457 against linezolid-resistant and -susceptible staphylococci and enterococci. |
| AID533011 | Antibacterial activity against vancomycin-intermediate Staphylococcus aureus BR2 phenotypic revertant after 24 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Improved antimicrobial activity of linezolid against vancomycin-intermediate Staphylococcus aureus. |
| AID559359 | Antimicrobial activity against compound-intermediate susceptible Coxiella burnetii Nine-Mile obtained from patient with acute Q fever infected in african green monkey Vero cells after 24 hrs by shell vial assay | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Bacteriostatic and bactericidal activities of tigecycline against Coxiella burnetii and comparison with those of six other antibiotics. |
| AID274228 | Antibacterial activity against Haemophilus influenzae HI3542 | 2006 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 16, Issue:20 | Synthesis and structure-activity studies of novel benzocycloheptanone oxazolidinone antibacterial agents. |
| AID295159 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae by microdilution broth method | 2007 | European journal of medicinal chemistry, Aug, Volume: 42, Issue:8 | Synthesis and antibacterial activity of oxazolidinones containing triazolyl group. |
| AID285357 | Decrease in Panton-Valentine leukocidin level in community acquired methicillin-resistant Staphylococcus aureus HT20041010 in CYY medium | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Effect of antibiotics on Staphylococcus aureus producing Panton-Valentine leukocidin. |
| AID207797 | Compound was evaluated for minimum inhibitory concentration against Staphylococcus aureus 9776 strain | 2002 | Bioorganic & medicinal chemistry letters, Mar-25, Volume: 12, Issue:6 | Synthesis and antibacterial activity of linezolid analogues. |
| AID583885 | Antibacterial activity against hospital-associated methicillin-resistant Staphylococcus aureus isolate 56 (494) by broth microdilution assay | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Comparative efficacies of human simulated exposures of telavancin and vancomycin against methicillin-resistant Staphylococcus aureus with a range of vancomycin MICs in a murine pneumonia model. |
| AID523830 | Antimicrobial activity against linezolid-resistant coagulase-negative Staphylococcus assessed as inhibition of microbial growth at 64 ug/ml by CLSI method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative activities of TR-700 (torezolid) against staphylococcal blood isolates collected in Spain. |
| AID559552 | Antimicrobial activity against compound-susceptible Coxiella burnetii isolate CP4 obtained from patient with acute Q fever infected in african green monkey Vero cells after 24 hrs by shell vial assay | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Bacteriostatic and bactericidal activities of tigecycline against Coxiella burnetii and comparison with those of six other antibiotics. |
| AID575046 | Cmin in human surgical patient plasma at 600 mg, iv or 600 mg, po administered every 12 hrs by HPLC | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Therapeutic drug monitoring of linezolid: a retrospective monocentric analysis. |
| AID1407935 | Antibacterial activity against Streptococcus pneumoniae ATCC 49619 after 24 hrs by broth microdilution method | 2018 | European journal of medicinal chemistry, Sep-05, Volume: 157 | Discovery of dual GyrB/ParE inhibitors active against Gram-negative bacteria. |
| AID267724 | Antimicrobial activity against Moraxella catarrhalis | 2006 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 16, Issue:13 | Synthesis and structure-activity studies of antibacterial oxazolidinones containing dihydrothiopyran or dihydrothiazine C-rings. |
| AID726186 | Inhibition of human MAO-B assessed as residual activity at 10 uM | 2013 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 23, Issue:5 | Synthesis and antibacterial activities of new piperidine substituted (5R)-[1,2,3]triazolylmethyl and (5R)-[(4-F-[1,2,3]triazolyl)methyl] oxazolidinones. |
| AID1594370 | Antibacterial activity against Pseudomonas aeruginosa ATCC 15442 after 18 to 24 hrs by broth microdilution assay | 2019 | Bioorganic & medicinal chemistry, 05-01, Volume: 27, Issue:9 | Second-generation aryl isonitrile compounds targeting multidrug-resistant Staphylococcus aureus. |
| AID625281 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cholelithiasis | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID1167987 | Antibacterial activity against vancomycin-resistant Enterococcus ATCC 51299 after overnight incubation by two-fold serial dilution method | 2014 | Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21 | Synthesis and biological evaluation of novel peptide BF2 as an antibacterial agent against clinical isolates of vancomycin-resistant enterococci. |
| AID245334 | In vitro minimum inhibitory concentration against Enterococcus faecalis [(VRE) ATCC 346-VRE and 5B-VRE] | 2005 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 15, Issue:12 | Synthesis and antibacterial activity of novel (un)substituted benzotriazolyl oxazolidinone derivatives. |
| AID576644 | Bactericidal activity against 13 hrs peripheral compartment culture samples of Staphylococcus aureus RN4220 MutS2 in two-compartment pharmacokinetic/pharmacodynamic model assessed as effect on bacterial count at 600 mg, bid administered as 0.5 hr infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID583390 | Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus isolate MU50 assessed as bacterial count at 32 times MIC after 24 hrs by colony counting method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | In vitro activity of the new multivalent glycopeptide-cephalosporin antibiotic TD-1792 against vancomycin-nonsusceptible Staphylococcus isolates. |
| AID763947 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after 18 hrs by NCCLS agar dilution method | 2013 | European journal of medicinal chemistry, Aug, Volume: 66 | Synthesis and antibacterial activities of N-substituted-glycinyl 1H-1,2,3-triazolyl oxazolidinones. |
| AID287264 | Antimicrobial activity against vancomycin-resistant Enterococcus by agar dilution method | 2007 | European journal of medicinal chemistry, Feb, Volume: 42, Issue:2 | Structure-antibacterial activity of arylcarbonyl- and arylsulfonyl-piperazine 5-triazolylmethyl oxazolidinones. |
| AID283636 | Antimicrobial activity against Staphylococcus aureus RN4220 deltamutS revertant with 23S rRNA G2576U mutation | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | In vitro activity of the oxazolidinone RWJ-416457 against linezolid-resistant and -susceptible staphylococci and enterococci. |
| AID558710 | Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus 1287 measured on day 40 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID318362 | Antibacterial activity against Staphylococcus aureus expressing antisense fabF assessed as drug level causing >5 mm zone of inhibition after 18 hrs by agar diffusion two plate differential sensitivity antisense assay | 2007 | Proceedings of the National Academy of Sciences of the United States of America, May-01, Volume: 104, Issue:18 | Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties. |
| AID352930 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis after 18 to 20 hrs by agar dilution method | 2009 | Bioorganic & medicinal chemistry letters, May-01, Volume: 19, Issue:9 | Synthesis and antibacterial activities of novel oxazolidinones having spiro[2,4]heptane moieties. |
| AID535001 | Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus assessed as susceptible isolates by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | In vitro activity of ceftaroline against community-associated methicillin-resistant, vancomycin-intermediate, vancomycin-resistant, and daptomycin-nonsusceptible Staphylococcus aureus isolates. |
| AID1390474 | Antibacterial activity against linezolid-resistant Staphylococcus epidermidis 1089191 | 2018 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 28, Issue:7 | Design, synthesis and biological evaluation of spiropyrimidinetriones oxazolidinone derivatives as antibacterial agents. |
| AID368284 | Cmax in rabbit plasma at 58 mg/kg after 12 hrs | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vivo efficacy of ceftaroline (PPI-0903), a new broad-spectrum cephalosporin, compared with linezolid and vancomycin against methicillin-resistant and vancomycin-intermediate Staphylococcus aureus in a rabbit endocarditis model. |
| AID583875 | Antibacterial activity against laboratory-derived Staphylococcus aureus isolate 29213-1 harboring ribosomal protein L3 Gly155Arg mutant by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Elevated linezolid resistance in clinical cfr-positive Staphylococcus aureus isolates is associated with co-occurring mutations in ribosomal protein L3. |
| AID383743 | Half life in Sprague-Dawley rat at 25 mg/kg, po | 2008 | European journal of medicinal chemistry, Apr, Volume: 43, Issue:4 | Synthesis and in vitro antibacterial activities of novel oxazolidinones. |
| AID1574834 | Antibacterial activity against Staphylococcus aureus ATCC 29213 by broth liquid microdilution method | 2019 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 29, Issue:3 | Design and synthesis of biaryloxazolidinone derivatives containing a rhodanine or thiohydantoin moiety as novel antibacterial agents against Gram-positive bacteria. |
| AID1308234 | Antibacterial activity against Bacillus licheniformis ATCC 12759 incubated for 16 to 20 hrs by microdilution method | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10 | Structure-Activity Relationship for the 4(3H)-Quinazolinone Antibacterials. |
| AID1501367 | Bactericidal activity against methicillin-resistant Staphylococcus aureus USA300 NRS384 incubated for 20 hrs followed by replating on tryptic soy agar plates and further incubated for 18 hrs by broth microdilution assay | 2017 | European journal of medicinal chemistry, Oct-20, Volume: 139 | Arylthiazole antibiotics targeting intracellular methicillin-resistant Staphylococcus aureus (MRSA) that interfere with bacterial cell wall synthesis. |
| AID444264 | Antibacterial activity against Streptococcus pyogenes ATCC 19615 by NCCLS method | 2009 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 19, Issue:22 | Synthesis and biological activity of novel oxazolidinones. |
| AID561242 | Antibacterial activity against methicillin-susceptible Staphylococcus epidermidis assessed as susceptible isolates by CLSI M100-S17 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | AFN-1252, a FabI inhibitor, demonstrates a Staphylococcus-specific spectrum of activity. |
| AID285096 | Antimicrobial activity against viridans group Streptococcus intermedius at 0.25 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID566580 | Antimicrobial activity against Staphylococcus lentus ATCC 29070 by conventional agar-dilution method | 2011 | European journal of medicinal chemistry, Jan, Volume: 46, Issue:1 | Discovery of a novel nitroimidazolyl-oxazolidinone hybrid with potent anti Gram-positive activity: Synthesis and antibacterial evaluation. |
| AID1710578 | Antibacterial activity against methicillin-resistant Staphylococcus aureus NRS123 assessed as inhibition of visible bacterial growth incubated for 18 to 20 hrs by CLSI method | 2020 | RSC medicinal chemistry, Jan-01, Volume: 11, Issue:1 | Potent trifluoromethoxy, trifluoromethylsulfonyl, trifluoromethylthio and pentafluorosulfanyl containing (1,3,4-oxadiazol-2-yl)benzamides against drug-resistant Gram-positive bacteria. |
| AID1139119 | Volume of distribution at steady state in rat at 2.8 to 9.5 mg/kg, iv | 2014 | Bioorganic & medicinal chemistry letters, May-01, Volume: 24, Issue:9 | Successful application of serum shift prediction models to the design of dual targeting inhibitors of bacterial gyrase B and topoisomerase IV with improved in vivo efficacy. |
| AID575149 | Antimicrobial activity against vancomycin-resistant Staphylococcus aureus VRS3 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Inhibition of antibiotic-resistant Staphylococcus aureus by the broad-spectrum dihydrofolate reductase inhibitor RAB1. |
| AID545802 | Antimicrobial activity against methicillin-sensitive Staphylococcus aureus ATCC 29213 planktonic cells by broth microdilution method in presence of 0.002% polysorbate 80 | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Oritavancin kills stationary-phase and biofilm Staphylococcus aureus cells in vitro. |
| AID285371 | Antibacterial activity against vancomycin-intermediate Staphylococcus aureus Mu50 by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Pharmacokinetic/pharmacodynamic factors influencing emergence of resistance to linezolid in an in vitro model. |
| AID561240 | Antibacterial activity against methicillin-resistant Staphylococcus aureus assessed as resistant isolates by CLSI M100-S17 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | AFN-1252, a FabI inhibitor, demonstrates a Staphylococcus-specific spectrum of activity. |
| AID245647 | Minimum inhibitory concentration against methicillin, ciprofloxacin, rifampin, imipenem-resistant Staphylococcus aureus UC12673; Range is 2-4 ug/mL | 2005 | Journal of medicinal chemistry, Jul-28, Volume: 48, Issue:15 | Conformational constraint in oxazolidinone antibacterials. Synthesis and structure-activity studies of (azabicyclo[3.1.0]hexylphenyl)oxazolidinones. |
| AID499142 | Ratio of fAUC to MIC in Staphylococcus aureus OC 4172 infected sc dosed SKH1 mouse | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vivo activity of ceftobiprole in murine skin infections due to Staphylococcus aureus and Pseudomonas aeruginosa. |
| AID577092 | Ratio of AUC (0 to 24 hrs) to MIC for Enterococcus faecalis Ef1497 MutM3 in two-compartment pharmacokinetic/pharmacodynamic model at 200 mg, bid administered as 0.5 hr infusion for 2 days | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID745405 | Antibacterial activity against linezolid-resistant Staphylococcus aureus NRS271 assessed as growth inhibition by CLSI broth microdilution method | 2013 | European journal of medicinal chemistry, May, Volume: 63 | Antibacterial oxazolidinone analogues having a N-hydroxyacetyl-substituted seven-membered [1,2,5]triazepane or [1,2,5]oxadiazepane C-ring unit. |
| AID1832939 | Antibacterial activity against Staphylococcus aureus NCTC 13616 assessed as reduction in bacterial growth incubated for 20 hrs by microplate reader method | 2021 | Bioorganic & medicinal chemistry, 11-01, Volume: 49 | Synthesis, microbiological evaluation and structure activity relationship analysis of linezolid analogues with different C5-acylamino substituents. |
| AID576886 | Ratio of Cmax to MIC for 0.5 hrs peripheral compartment culture samples of Enterococcus faecalis ATCC 29212 in two-compartment pharmacokinetic/pharmacodynamic model at 200 mg, bid administered as 0.5 hr infusion for 2 days | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID1609274 | Bactericidal activity against methicilline-resistant Staphylococcus aureus NRS385 USA500 incubated for 18 to 20 hrs followed by replating on tryptic soy agar plate and further incubated for 18 to 24 hrs by CLSI-based broth microdilution assay | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Phenylthiazoles with nitrogenous side chain: An approach to overcome molecular obesity. |
| AID745401 | Antibacterial activity against Streptococcus pneumoniae SR26207 clinical isolate assessed as growth inhibition by CLSI broth microdilution method | 2013 | European journal of medicinal chemistry, May, Volume: 63 | Antibacterial oxazolidinone analogues having a N-hydroxyacetyl-substituted seven-membered [1,2,5]triazepane or [1,2,5]oxadiazepane C-ring unit. |
| AID590059 | Antibacterial activity against methicillin-resistant Staphylococcus aureus by agar dilution method | 2011 | European journal of medicinal chemistry, Apr, Volume: 46, Issue:4 | Discovery of torezolid as a novel 5-hydroxymethyl-oxazolidinone antibacterial agent. |
| AID595023 | Antibacterial activity against Staphylococcus aureus ATCC 25923 | 2011 | Bioorganic & medicinal chemistry letters, May-15, Volume: 21, Issue:10 | Synthesis and in vitro activity of novel 1,2,4-triazolo[4,3-a]pyrimidine oxazolidinone antibacterial agents. |
| AID520766 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus infected in New Zealand rabbit osteomyelitis model assessed as improvement in extent of bone remodeling at 60 mg/kg, po administered every 8 hrs for 4 weeks measured on week 6 post | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Efficacies of ceftobiprole medocaril and comparators in a rabbit model of osteomyelitis due to methicillin-resistant Staphylococcus aureus. |
| AID467840 | Antibacterial activity against Streptococcus pyogenes after 24 hrs by agar dilution method | 2009 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 19, Issue:23 | Novel 4-N-substituted aryl but-3-ene-1,2-dione derivatives of piperazinyloxazolidinones as antibacterial agents. |
| AID475007 | Antibacterial activity against Escherichia coli LCB0012 by two fold serial dilution method | 2010 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 20, Issue:7 | Synthesis, crystal and antibacterial studies of diversely functionalized tetrahydropyridin-4-ol. |
| AID1434682 | Anti-bacterial activity against methicillin-resistant Staphylococcus aureus CCARM 3635 by 2-fold microtiter broth dilution method | 2017 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 27, Issue:3 | Cadiolides J-M, antibacterial polyphenyl butenolides from the Korean tunicate Pseudodistoma antinboja. |
| AID475004 | Antibacterial activity against Enterococcus faecium LCB0009 by two fold serial dilution method | 2010 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 20, Issue:7 | Synthesis, crystal and antibacterial studies of diversely functionalized tetrahydropyridin-4-ol. |
| AID115955 | Minimum inhibitory concentration in mice against antimicrobial activity in methicillin-resistant Staphylococcus pneumoniae (PISP 49619). | 2004 | Bioorganic & medicinal chemistry letters, May-03, Volume: 14, Issue:9 | DNA binding ligands with in vivo efficacy in murine models of bacterial infection: optimization of internal aromatic amino acids. |
| AID520767 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus infected in New Zealand rabbit osteomyelitis model assessed as improvement in rate of bone reconstruction at 60 mg/kg, po administered every 8 hrs for 4 weeks measured on week 8 po | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Efficacies of ceftobiprole medocaril and comparators in a rabbit model of osteomyelitis due to methicillin-resistant Staphylococcus aureus. |
| AID1609278 | Bactericidal activity against methicilline-sensitive Staphylococcus aureus NRS-107 incubated for 18 to 20 hrs followed by replating on tryptic soy agar plate and further incubated for 18 to 24 hrs by CLSI-based broth microdilution assay | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Phenylthiazoles with nitrogenous side chain: An approach to overcome molecular obesity. |
| AID206822 | Antibacterial activity against Staphylococcus pyogenes | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | Iclaprim, a novel diaminopyrimidine with potent activity on trimethoprim sensitive and resistant bacteria. |
| AID520018 | Antimicrobial activity against Staphylococcus aureus pL150 | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID576674 | Bactericidal activity against 48 hrs peripheral compartment culture samples of Enterococcus faecalis Ef1497 in two-compartment pharmacokinetic/pharmacodynamic model assessed as effect on bacterial count at 600 mg, bid administered as 0.5 hr infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID645042 | Antibacterial activity against methicillin-resistant glycopeptide-intermediate Staphylococcus aureus Mu50 after 16 to 20 hrs by microbroth dilution method | 2012 | European journal of medicinal chemistry, Apr, Volume: 50 | Synthesis and preliminary antibacterial evaluation of Linezolid-like 1,2,4-oxadiazole derivatives. |
| AID429065 | Antiplasmodial activity after 96 hrs against Plasmodium falciparum 3D7 as Malstat LDH activity | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Telithromycin and quinupristin-dalfopristin induce delayed death in Plasmodium falciparum. |
| AID710151 | Antibacterial activity against community acquired methicillin-resistant Staphylococcus aureus | 2012 | Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22 | From triclosan toward the clinic: discovery of nonbiocidal, potent FabI inhibitors for the treatment of resistant bacteria. |
| AID558478 | Antimicrobial activity against vancomycin-resistant Staphylococcus aureus 509 measured on day 5 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID560370 | Antimicrobial activity against vancomycin-resistant Enterococcus faecalis ATCC 51299 by broth dilution method in presence of 4% HSA | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Impact of human serum albumin on oritavancin in vitro activity against enterococci. |
| AID581040 | Inhibition of ribosomal activity in Escherichia coli S30 by coupled transcription/translation assay | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Mode of action of Ranbezolid against staphylococci and structural modeling studies of its interaction with ribosomes. |
| AID410340 | Antimicrobial activity against Haemophilus influenzae 895 (AcrB-KO) by NCCLS method | 2008 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 18, Issue:23 | Design at the atomic level: design of biaryloxazolidinones as potent orally active antibiotics. |
| AID625289 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver disease | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID283632 | Antimicrobial activity against Staphylococcus aureus RN4220 | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | In vitro activity of the oxazolidinone RWJ-416457 against linezolid-resistant and -susceptible staphylococci and enterococci. |
| AID1609271 | Bactericidal activity against vancomycin-resistant Staphylococcus aureus 12 incubated for 18 to 20 hrs followed by replating on tryptic soy agar plate and further incubated for 18 to 24 hrs by CLSI-based broth microdilution assay | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Phenylthiazoles with nitrogenous side chain: An approach to overcome molecular obesity. |
| AID1400756 | Hemolytic activity in human RBC at 200 uM after 1 hr relative to control | 2017 | MedChemComm, Apr-01, Volume: 8, Issue:4 | Microwave-enhanced Friedländer synthesis for the rapid assembly of halogenated quinolines with antibacterial and biofilm eradication activities against drug resistant and tolerant bacteria. |
| AID208149 | Minimum inhibitory concentration Streptococcus pneumoniae UC9912 | 1998 | Journal of medicinal chemistry, Sep-10, Volume: 41, Issue:19 | Piperazinyl oxazolidinone antibacterial agents containing a pyridine, diazene, or triazene heteroaromatic ring. |
| AID552835 | Antibacterial activity against multidrug-resistant Enterococcus faecium | 2011 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1 | The discovery and structure-activity relationships leading to CE-156811, a difluorophenyl cyclopropyl fluoroether: a novel potent antibacterial analog derived from hygromycin A. |
| AID283627 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus Ho 4280-0256 with heterozygous 23S rRNA G2576U mutation | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | In vitro activity of the oxazolidinone RWJ-416457 against linezolid-resistant and -susceptible staphylococci and enterococci. |
| AID542899 | fT>MIC in Bacillus anthracis infected in vitro hollow fiber PK/PD model at simulated dose of 400 mg administered every 12 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID1744564 | Antibacterial activity against methicillin resistant Staphylococcus aureus assessed as inhibition of bacterial growth measured after 16 hrs by agar plate dilution method | 2021 | ACS medicinal chemistry letters, Mar-11, Volume: 12, Issue:3 | Semisynthesis and Biological Evaluation of Platencin Thioether Derivatives: Dual FabF and FabH Inhibitors against MRSA. |
| AID348604 | Antibacterial activity against vancomycin-resistant Enterococcus faecium 2 after 18 to 20 hrs by agar dilution method | 2008 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 18, Issue:21 | Synthesis and antibacterial activities of novel oxazolidinones having cyclic sulfonamide moieties. |
| AID1167732 | Antimicrobial activity against Streptococcus pyogenes by broth microdilution method | 2014 | Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21 | Novel DNA gyrase inhibiting spiropyrimidinetriones with a benzisoxazole scaffold: SAR and in vivo characterization. |
| AID205577 | Antibacterial activity against Staphylococcus epidermidis UC30031UC | 1998 | Bioorganic & medicinal chemistry letters, May-19, Volume: 8, Issue:10 | Synthesis and antibacterial activity of [6,5,5] and [6,6,5] tricyclic fused oxazolidinones. |
| AID326293 | Antibacterial activity against methicillin-resistant Staphylococcus aureus 5098 at 4 hrs daily exposure for 5 days by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Comparative activities of daptomycin, linezolid, and tigecycline against catheter-related methicillin-resistant Staphylococcus bacteremic isolates embedded in biofilm. |
| AID565229 | Antimicrobial activity against Mycobacterium chelonae ATCC 35752 harboring pZS01 carrying mspA gene by resazurine microtiter assay | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Role of porins in the susceptibility of Mycobacterium smegmatis and Mycobacterium chelonae to aldehyde-based disinfectants and drugs. |
| AID573150 | Antibacterial activity against vancomycin-susceptible Enterococcus faecalis assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID542697 | fCmax in Bacillus anthracis infected in vitro hollow fiber PK/PD model at simulated dose of 500 mg /day administered as 2 divided doses every 12 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID574063 | Cmax in CF-1 mouse at 2 mg/kg, iv | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | In vivo activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. |
| AID206436 | In vitro antibacterial activity against ciprofloxacin and oxazolidinone Linezolid resistant Staphylococcus aureus ATCC 29213 (Saul) | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | Structure-activity relationship in the oxazolidinone-quinolone hybrid series: influence of the central spacer on the antibacterial activity and the mode of action. |
| AID12298 | Half life of compound (10 mg/kg) after iv administration was determined in Sprague-Dawley rat | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | The effect of remote chirality on the antibacterial activity of indolinyl, tetrahydroquinolyl and dihydrobenzoxazinyl oxazolidinones. |
| AID352931 | Antibacterial activity against vancomycin-resistant Enterococcus faecium after 18 to 20 hrs by agar dilution method | 2009 | Bioorganic & medicinal chemistry letters, May-01, Volume: 19, Issue:9 | Synthesis and antibacterial activities of novel oxazolidinones having spiro[2,4]heptane moieties. |
| AID560367 | Antimicrobial activity against vancomycin-resistant Enterococcus faecium 1059060 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Impact of human serum albumin on oritavancin in vitro activity against enterococci. |
| AID1375990 | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv harboring cyd deletion mutant measured after 2 weeks by microplate alamar blue assay | 2016 | MedChemComm, Nov-01, Volume: 7, Issue:11 | SAR and identification of 2-(quinolin-4-yloxy)acetamides as |
| AID260741 | Antibacterial activity against Enterococcus faecalis 29212 | 2006 | Journal of medicinal chemistry, Feb-23, Volume: 49, Issue:4 | Hybrid antibacterials. DNA polymerase-topoisomerase inhibitors. |
| AID1493803 | Antibacterial activity against Staphylococcus aureus USA400 NRS123 clinical isolate after 20 hrs by broth microdilution method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Biphenylthiazole antibiotics with an oxadiazole linker: An approach to improve physicochemical properties and oral bioavailability. |
| AID285386 | Area under population analysis profile for heteroresistant vancomycin-intermediate Staphylococcus aureus Mu3 using in vitro PK/PD model relative to growth control with 120 mg/24 hrs continuous infusion regimen after 72 hrs | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Pharmacokinetic/pharmacodynamic factors influencing emergence of resistance to linezolid in an in vitro model. |
| AID468443 | Inhibition of human FAAH at 1 uM | 2009 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 19, Issue:23 | Mining biologically-active molecules for inhibitors of fatty acid amide hydrolase (FAAH): identification of phenmedipham and amperozide as FAAH inhibitors. |
| AID533953 | Antimicrobial activity against Listeria monocytogenes EGD after 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Cellular pharmacodynamics of the novel biaryloxazolidinone radezolid: studies with infected phagocytic and nonphagocytic cells, using Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Legionella pneumophila. |
| AID284941 | Antimicrobial activity against Aerococcus spp. at 0.25 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID574553 | Decrease in PSMbeta1 levels in Staphylococcus aureus Sanger 252 at subinhibitory concentrations after 24 hrs by RP-HPLC/ESI- MS | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Subinhibitory concentrations of protein synthesis-inhibiting antibiotics promote increased expression of the agr virulence regulator and production of phenol-soluble modulin cytolysins in community-associated methicillin-resistant Staphylococcus aureus. |
| AID630561 | Antibacterial activity against linezolid-resistant Enterococcus faecalis after 16 hrs by agar dilution method | 2011 | Journal of medicinal chemistry, Nov-10, Volume: 54, Issue:21 | Design, synthesis, and structure-activity relationship studies of highly potent novel benzoxazinyl-oxazolidinone antibacterial agents. |
| AID1271210 | Metabolic stability in mouse liver microsomes after 30 mins by LC-MS/MS analysis | 2015 | ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11 | Design, Synthesis, and Identification of Silicon Incorporated Oxazolidinone Antibiotics with Improved Brain Exposure. |
| AID528846 | Antimicrobial activity against methicillin-resistant Staphylococcus epidermidis isolated from ICU patient urine assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID245136 | Minimum inhibitory concentration against Staphylococcus aureus ATCC 13709; value ranges from 3-6 uM | 2004 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 14, Issue:22 | Aryl urea analogs with broad-spectrum antibacterial activity. |
| AID1553368 | Antibacterial activity against Staphylococcus aureus JC9213 by CLSI based broth dilution assay | 2019 | Bioorganic & medicinal chemistry letters, 09-15, Volume: 29, Issue:18 | Incorporation of a chiral gem-disubstituted nitrogen heterocycle yields an oxazolidinone antibiotic with reduced mitochondrial toxicity. |
| AID1594068 | Antibacterial activity against Escherichia coli assessed as reduction in bacterial cell viability incubated for 20 to 24 hrs by REMA method | 2019 | Bioorganic & medicinal chemistry, 06-15, Volume: 27, Issue:12 | Design, synthesis, in-silico studies and biological screening of quinazolinone analogues as potential antibacterial agents against MRSA. |
| AID522911 | Antibacterial activity against hospital-acquired methicillin-resistant Staphylococcus aureus isolate 1766 after 24 hrs by modified broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Antistaphylococcal activity of ACHN-490 tested alone and in combination with other agents by time-kill assay. |
| AID528693 | Antibacterial activity against multidrug resistant Streptococcus pneumoniae MED 1090 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID1778660 | Bactericidal activity against penicillin-resistant Staphylococcus aureus measured after 24 hrs by CLSI protocol based method | 2021 | European journal of medicinal chemistry, Oct-05, Volume: 221 | Design, synthesis and evaluation of novel 9-arylalkyl-10-methylacridinium derivatives as highly potent FtsZ-targeting antibacterial agents. |
| AID560830 | Ratio of AUC (0 to 12 hrs) in human adults with pulmonary tuberculosis at 600 mg administered twice daily for 5 days to MIC for Mycobacterium tuberculosis | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Population pharmacokinetics of linezolid in adults with pulmonary tuberculosis. |
| AID525147 | Antimicrobial activity against linezolid-resistant Staphylococcus aureus isolate 004-737X expressing cfr and ermA gene isolated from paraplegic patient by disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | First report of cfr-mediated resistance to linezolid in human staphylococcal clinical isolates recovered in the United States. |
| AID1308237 | Antibacterial activity against Enterococcus faecium NCTC 7171 incubated for 16 to 20 hrs by microdilution method | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10 | Structure-Activity Relationship for the 4(3H)-Quinazolinone Antibacterials. |
| AID283165 | Antimicrobial susceptibility of Staphylococcus lugdunensis IDRL2664 biofilms after 24 hrs assessed as bacterial regrowth | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | In vitro effects of antimicrobial agents on planktonic and biofilm forms of Staphylococcus lugdunensis clinical isolates. |
| AID542698 | fCmax in Bacillus anthracis infected in vitro hollow fiber PK/PD model at simulated dose of 500 mg /day administered as 6 divided doses every 4 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID85780 | In vitro antibacterial activity against Haemophilia influenzae strains 30063 and ATCC 31517 (HI); range is 8-16 | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | New antibacterial tetrahydro-4(2H)-thiopyran and thiomorpholine S-oxide and S,S-dioxide phenyloxazolidinones. |
| AID284976 | Antimicrobial activity against Corynebacterium striatum at <= 0.06 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID1609273 | Bactericidal activity against methicilline-resistant Staphylococcus aureus NRS386 USA700 incubated for 18 to 20 hrs followed by replating on tryptic soy agar plate and further incubated for 18 to 24 hrs by CLSI-based broth microdilution assay | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Phenylthiazoles with nitrogenous side chain: An approach to overcome molecular obesity. |
| AID1473741 | Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and GSH measured after 20 mins by membrane vesicle transport assay | 2013 | Toxicological sciences : an official journal of the Society of Toxicology, Nov, Volume: 136, Issue:1 | A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. |
| AID555309 | Antibacterial activity against methicillin-resistant coagulase-negative Staphylococcus epidermidis 197 by broth macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Antistaphylococcal activity of dihydrophthalazine antifolates, a family of novel antibacterial drugs. |
| AID1407932 | Antibacterial activity against methicillin-resistant Staphylococcus aureus FQ-R after 24 hrs by broth microdilution method | 2018 | European journal of medicinal chemistry, Sep-05, Volume: 157 | Discovery of dual GyrB/ParE inhibitors active against Gram-negative bacteria. |
| AID1539449 | Antibacterial activity against vancomycin-resistant Staphylococcus aureus isolate 10 after 18 to 20 hrs in aerobic condition by CLSI-based broth microdilution assay | |||
| AID523792 | Antimicrobial activity against oxacillin-resistant Staphylococcus aureus assessed as inhibition of microbial growth at 0.5 ug/ml by CLSI method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative activities of TR-700 (torezolid) against staphylococcal blood isolates collected in Spain. |
| AID558084 | Antimicrobial activity against Mycoplasma genitalium isolated from human by two fold serial dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Comparative in vitro susceptibilities of human mycoplasmas and ureaplasmas to a new investigational ketolide, CEM-101. |
| AID1481713 | Potentiation of imipenem-induced antibacterial activity against methicillin-resistant Staphylococcus aureus COL MB 5393 infected in neutropenic balb/c mouse assessed as reduction in bacterial burden in kidney at 10 mg/kg, sc administered three times per d | 2017 | Journal of medicinal chemistry, 05-11, Volume: 60, Issue:9 | Can We Make Small Molecules Lean? Optimization of a Highly Lipophilic TarO Inhibitor. |
| AID577143 | Volume of distribution at steady state in two-compartment pharmacokinetic/pharmacodynamic model at 400 mg, bid administered as 0.5 hr infusion over 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID1395980 | Induction of biofilm eradication of methicillin-resistant Staphylococcus aureus BAA-1707 after 24 hrs by calgary biofilm device method | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9 | An Efficient Buchwald-Hartwig/Reductive Cyclization for the Scaffold Diversification of Halogenated Phenazines: Potent Antibacterial Targeting, Biofilm Eradication, and Prodrug Exploration. |
| AID483193 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 by microbroth dilution technique | 2010 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 20, Issue:12 | Design, synthesis, and antibacterial activity of 2,5-dihydropyrrole formyl hydroxyamino derivatives as novel peptide deformylase inhibitors. |
| AID1852695 | Antibacterial activity against Escherichia coli SQ110 DTC C2610A incubated for 24 hrs by twofold serial dilution method | |||
| AID208944 | In vitro minimum inhibitory concentration (MIC) against Streptococcus pneumoniae UC9912 | 2003 | Journal of medicinal chemistry, Jan-16, Volume: 46, Issue:2 | Identification of phenylisoxazolines as novel and viable antibacterial agents active against Gram-positive pathogens. |
| AID1596557 | Antibacterial activity against Listeria monocytogenes ATCC 19111 assessed as reduction in bacterial cell growth incubated for 18 to 20 hrs by broth microdilution method | 2019 | European journal of medicinal chemistry, Aug-01, Volume: 175 | Lipophilic efficient phenylthiazoles with potent undecaprenyl pyrophosphatase inhibitory activity. |
| AID544828 | Antimicrobial activity against Staphylococcus epidermidis Xen 43 biofilm assessed as log10 CFU/cm'2 in bacterial count | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Effect of electrical current on the activities of antimicrobial agents against Pseudomonas aeruginosa, Staphylococcus aureus, and Staphylococcus epidermidis biofilms. |
| AID565017 | Antimicrobial activity against methicillin-susceptible coagulase-negative Staphylococcus sciuri assessed as susceptible isolates after 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID567451 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus CGK3 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Development of daptomycin nonsusceptibility with heterogeneous vancomycin-intermediate resistance and oxacillin susceptibility in methicillin-resistant Staphylococcus aureus during high-dose daptomycin treatment. |
| AID1861519 | Antibacterial activity against methicillin-resistant Staphylococcus aureus Sta-032 incubated for 18 hrs by CLSI protocol based two-fold serial agar dilution method | 2022 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 71 | WCK 4034: A promising oxazolidinone for treating gram positive infections. |
| AID1591541 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 incubated for 24 hrs by CLSI protocol based broth microdilution method | 2019 | Bioorganic & medicinal chemistry, 07-15, Volume: 27, Issue:14 | Discovery of 1,3,4-oxadiazol-2-one-containing benzamide derivatives targeting FtsZ as highly potent agents of killing a variety of MDR bacteria strains. |
| AID261062 | Antibacterial activity against Streptococcus pneumoniae SVI SP-3 | 2006 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 16, Issue:5 | Conformational constraint in oxazolidinone antibacterials. Part 2: Synthesis and structure-activity studies of oxa-, aza-, and thiabicyclo[3.1.0]hexylphenyl oxazolidinones. |
| AID323808 | Reduction in bioluminescent methicillin-sensitive Staphylococcus aureus Xen29 in immunocompetent CD1 mouse with peritonitis at 100 mg/kg, po after 5 hrs relative to control | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Rapid bactericidal activity of daptomycin against methicillin-resistant and methicillin-susceptible Staphylococcus aureus peritonitis in mice as measured with bioluminescent bacteria. |
| AID1409853 | Antibacterial activity against linezolid-resistant Staphylococcus aureus NRS271 infected in BALB/c mouse assessed as reduction of bacterial burden in heart at 0.4 mg, ip bid administered at 12 hrs prior to bacterial infection dosed at 12 intervals for 4.5 | 2018 | ACS medicinal chemistry letters, Mar-08, Volume: 9, Issue:3 | Novel Staphyloxanthin Inhibitors with Improved Potency against Multidrug Resistant |
| AID287266 | Antimicrobial activity against Moraxella catarrhalis | 2007 | European journal of medicinal chemistry, Feb, Volume: 42, Issue:2 | Structure-antibacterial activity of arylcarbonyl- and arylsulfonyl-piperazine 5-triazolylmethyl oxazolidinones. |
| AID562187 | Antimicrobial activity against vancomycin-resistant Staphylococcus aureus 510 after 50 passages by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID1446762 | Antibacterial activity against vancomycin-resistant Staphylococcus aureus VRSA10 after 20 hrs by broth microdilution method | 2017 | European journal of medicinal chemistry, Apr-21, Volume: 130 | Diphenylurea derivatives for combating methicillin- and vancomycin-resistant Staphylococcus aureus. |
| AID522899 | Antibacterial activity against vancomycin-intermediate Staphylococcus aureus isolate 1016 after 24 hrs by modified broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Antistaphylococcal activity of ACHN-490 tested alone and in combination with other agents by time-kill assay. |
| AID1400751 | Antibiofilm activity against methicillin-resistant Staphylococcus aureus isolate 2 after 24 hrs by calgary biofilm device-based assay | 2017 | MedChemComm, Apr-01, Volume: 8, Issue:4 | Microwave-enhanced Friedländer synthesis for the rapid assembly of halogenated quinolines with antibacterial and biofilm eradication activities against drug resistant and tolerant bacteria. |
| AID523832 | Antimicrobial activity against linezolid-resistant coagulase-negative Staphylococcus assessed as inhibition of microbial growth at 256 ug/ml by CLSI method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative activities of TR-700 (torezolid) against staphylococcal blood isolates collected in Spain. |
| AID559559 | Antimicrobial activity against compound-resistant Coxiella burnetii isolate CP7 obtained from patient with acute Q fever infected in african green monkey Vero cells after 24 hrs by shell vial assay | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Bacteriostatic and bactericidal activities of tigecycline against Coxiella burnetii and comparison with those of six other antibiotics. |
| AID558514 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus 547 measured on day 25 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID1435923 | Antibacterial activity against methicillin-resistant Staphylococcus aureus USA400 NRS123 clinical isolate after 18 to 20 hrs by broth microdilution method | 2017 | European journal of medicinal chemistry, Jan-27, Volume: 126 | Phenylthiazole antibiotics: A metabolism-guided approach to overcome short duration of action. |
| AID287265 | Antimicrobial activity against Haemophilus influenzae | 2007 | European journal of medicinal chemistry, Feb, Volume: 42, Issue:2 | Structure-antibacterial activity of arylcarbonyl- and arylsulfonyl-piperazine 5-triazolylmethyl oxazolidinones. |
| AID1609272 | Bactericidal activity against vancomycin-resistant Staphylococcus aureus 10 incubated for 18 to 20 hrs followed by replating on tryptic soy agar plate and further incubated for 18 to 24 hrs by CLSI-based broth microdilution assay | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Phenylthiazoles with nitrogenous side chain: An approach to overcome molecular obesity. |
| AID424762 | Antibacterial activity against ampicillin-sensitive Staphylococcus haemolyticus CL8544 after 20 hrs by twofold serial broth dilution method | 2009 | Journal of natural products, May-22, Volume: 72, Issue:5 | Thiazomycins, thiazolyl peptide antibiotics from Amycolatopsis fastidiosa. |
| AID637973 | Antibacterial activity against Streptococcus pneumoniae ATCC 49619 after overnight incubation by twofold broth dilution technique | 2012 | Bioorganic & medicinal chemistry, Jan-01, Volume: 20, Issue:1 | Efficient microwave-assisted synthesis, antibacterial activity and high fluorescence of 5 benzimidazolyl-2'-deoxyuridines. |
| AID1197122 | Antibacterial activity against Staphylococcus haemolyticus ATCC 29970 after 16 to 20 hrs by broth microdilution method | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3 | Structure-activity relationship for the oxadiazole class of antibiotics. |
| AID283619 | Antimicrobial activity against Enterococcus faecium 18 with heterozygous 23S rRNA G2576U mutation | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | In vitro activity of the oxazolidinone RWJ-416457 against linezolid-resistant and -susceptible staphylococci and enterococci. |
| AID297122 | Antibacterial activity against methicillin-resistant Staphylococcus aureus Mu50 after 18 hrs by agar plate dilution method | 2007 | Journal of medicinal chemistry, Aug-23, Volume: 50, Issue:17 | Discovery of 1,4-dihydroxy-2-naphthoate [corrected] prenyltransferase inhibitors: new drug leads for multidrug-resistant gram-positive pathogens. |
| AID375939 | Antibacterial activity against methicillin-resistant Staphylococcus aureus 78-13607A after 24 hrs by broth microdilution method | 2006 | Journal of natural products, Apr, Volume: 69, Issue:4 | Antibacterial, partially acetylated oligorhamnosides from Cleistopholis patens. |
| AID1205587 | Inhibition of Escherichia coli switch region of RNA polymerase after 1 hr by transcription-coupled translation assay | 2015 | Journal of medicinal chemistry, Apr-09, Volume: 58, Issue:7 | X-ray crystal structures of Escherichia coli RNA polymerase with switch region binding inhibitors enable rational design of squaramides with an improved fraction unbound to human plasma protein. |
| AID576671 | Bactericidal activity against 13 hrs peripheral compartment culture samples of Enterococcus faecalis Ef1497 in two-compartment pharmacokinetic/pharmacodynamic model assessed as effect on bacterial count at 600 mg, bid administered as 0.5 hr infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID1205589 | Partition coefficient, log D of the compound at pH 7.4 by shake flask method | 2015 | Journal of medicinal chemistry, Apr-09, Volume: 58, Issue:7 | X-ray crystal structures of Escherichia coli RNA polymerase with switch region binding inhibitors enable rational design of squaramides with an improved fraction unbound to human plasma protein. |
| AID244932 | Minimal inhibitory concentration against Klebsiella pneumoniae ATCC 15380 | 2004 | Bioorganic & medicinal chemistry letters, Sep-20, Volume: 14, Issue:18 | Synthesis and antibacterial activity of some aryloxy/thioaryloxy oxazolidinone derivatives. |
| AID127519 | In vitro antibacterial activity against Moraxella catarrhalis strains 30607 and 30603 (MC); range is 4-8 | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | New antibacterial tetrahydro-4(2H)-thiopyran and thiomorpholine S-oxide and S,S-dioxide phenyloxazolidinones. |
| AID210055 | Compound was evaluated for minimum inhibitory concentration against Streptococcus pneumoniae 9757 strain | 2002 | Bioorganic & medicinal chemistry letters, Mar-25, Volume: 12, Issue:6 | Synthesis and antibacterial activity of linezolid analogues. |
| AID1873887 | Induction of drug resistance in Escherichia coli ATCC 25922 assessed as increase in MIC measured after 30 passages by broth microdilution method | 2022 | European journal of medicinal chemistry, Aug-05, Volume: 238 | Design, synthesis and activity against drug-resistant bacteria evaluation of C-20, C-23 modified 5-O-mycaminosyltylonolide derivatives. |
| AID559802 | Antimicrobial activity against vancomycin-susceptible Staphylococcus aureus assessed as growth inhibition at 4 times MIC | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID68056 | In vitro minimum inhibitory concentration (MIC) against Enterococcus faecalis UC9217 | 2003 | Journal of medicinal chemistry, Jan-16, Volume: 46, Issue:2 | Identification of phenylisoxazolines as novel and viable antibacterial agents active against Gram-positive pathogens. |
| AID370039 | Fraction unbound in Staphylococcus aureus-infected mouse localized thigh infection model plasma at 25 mg/kg | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vivo efficacy of a novel oxazolidinone compound in two mouse models of infection. |
| AID1907629 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC2858 incubated for 18 to 20 hrs by double dilution method | 2022 | European journal of medicinal chemistry, Jun-05, Volume: 236 | Novel benzothiazole‒urea hybrids: Design, synthesis and biological activity as potent anti-bacterial agents against MRSA. |
| AID206210 | In vitro minimum inhibitory concentration (MIC) against Staphylococcus epidermidis UC12084 | 2003 | Journal of medicinal chemistry, Jan-16, Volume: 46, Issue:2 | Identification of phenylisoxazolines as novel and viable antibacterial agents active against Gram-positive pathogens. |
| AID533392 | Antimicrobial activity against Clostridium perfringens assessed as resistant isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activities of doripenem, a new broad-spectrum carbapenem, against recently collected clinical anaerobic isolates, with emphasis on the Bacteroides fragilis group. |
| AID285125 | Antimicrobial activity against viridans group Streptococcus salivarius at 0.12 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID567449 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus CGK1 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Development of daptomycin nonsusceptibility with heterogeneous vancomycin-intermediate resistance and oxacillin susceptibility in methicillin-resistant Staphylococcus aureus during high-dose daptomycin treatment. |
| AID576416 | Apparent volume of distribution in two-compartment pharmacokinetic/pharmacodynamic model at 800 mg, bid administered as 0.5 hrs infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID523831 | Antimicrobial activity against linezolid-resistant coagulase-negative Staphylococcus assessed as inhibition of microbial growth at 128 ug/ml by CLSI method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative activities of TR-700 (torezolid) against staphylococcal blood isolates collected in Spain. |
| AID520520 | AUC in methicillin-resistant Staphylococcus aureus-infected New Zealand rabbit osteomyelitis model at 60 mg/kg, po after 24 hrs | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Efficacies of ceftobiprole medocaril and comparators in a rabbit model of osteomyelitis due to methicillin-resistant Staphylococcus aureus. |
| AID369674 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus Smith infected in C3H mouse assessed as mortality at 12.5 mg/kg/day, po administered within 15 mins of infection measured after 48 hrs by organ burden assay relative to control | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vivo efficacy of a novel oxazolidinone compound in two mouse models of infection. |
| AID560502 | Antimicrobial activity against SCCmec type III vancomycin-intermediate Staphylococcus aureus isolate gz06051 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID1553386 | Inhibition of SDH-A (unknown origin) by ELISA | 2019 | Bioorganic & medicinal chemistry letters, 09-15, Volume: 29, Issue:18 | Incorporation of a chiral gem-disubstituted nitrogen heterocycle yields an oxazolidinone antibiotic with reduced mitochondrial toxicity. |
| AID93890 | Minimum inhibitory concentration against Klebsiella pneumoniae ATCC 10031 | 2004 | Bioorganic & medicinal chemistry letters, Jun-21, Volume: 14, Issue:12 | Oxazolidinone: search for highly potent antibacterial. |
| AID499115 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus OC 8525 infected immunocompromized SKH1 mouse assessed as lesion volume at 6.2 mg/kg/day, sc measured after 48 hrs postinfection (Rvb = 1535 mm3) | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vivo activity of ceftobiprole in murine skin infections due to Staphylococcus aureus and Pseudomonas aeruginosa. |
| AID1676979 | Antimicrobial activity against vancomycin-resistant Enterococcus faecium ATCC 700221 assessed as reduction in microbial growth after 48 hrs by CLSI based broth microdilution method | |||
| AID533986 | Bacteriostatic activity against linezolid-susceptible Staphylococcus aureus SA040 infected in THP1 cells after 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Cellular pharmacodynamics of the novel biaryloxazolidinone radezolid: studies with infected phagocytic and nonphagocytic cells, using Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Legionella pneumophila. |
| AID283634 | Antimicrobial activity against Staphylococcus aureus RN4220 with 23S rRNA G2576U mutation | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | In vitro activity of the oxazolidinone RWJ-416457 against linezolid-resistant and -susceptible staphylococci and enterococci. |
| AID523797 | Antimicrobial activity against linezolid-resistant coagulase-negative Staphylococcus by CLSI method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative activities of TR-700 (torezolid) against staphylococcal blood isolates collected in Spain. |
| AID759694 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus ATCC 29213 assessed as growth inhibition after 18 to 24 hrs by broth microdilution method | 2013 | European journal of medicinal chemistry, Jul, Volume: 65 | New linezolid-like 1,2,4-oxadiazoles active against Gram-positive multiresistant pathogens. |
| AID285078 | Antimicrobial activity against viridans group Streptococcus bovis at 0.12 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID292608 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus 33 by agar dilution method | 2007 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 17, Issue:17 | Synthesis and antibacterial activity of novel oxazolidinones with methylene oxygen- and methylene sulfur-linked substituents at C5-position. |
| AID533939 | Antimicrobial activity against linezolid-resistant Staphylococcus aureus 480 harboring G2447U in peptidyl transferase centre by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains. |
| AID541083 | Cmax in cage fluid of Albino guiena pig at 25 mg/kg, ip after 3 hrs | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Linezolid alone or combined with rifampin against methicillin-resistant Staphylococcus aureus in experimental foreign-body infection. |
| AID574064 | Cmax in CF-1 mouse at 10 mg/kg, sc | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | In vivo activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. |
| AID528702 | Antibacterial activity against Streptococcus constellatus clinical isolate assessed as susceptibility level by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID1704211 | Antibacterial activity against Methicillin-resistant Staphylococcus aureus KU60 | 2020 | European journal of medicinal chemistry, Nov-15, Volume: 206 | 1,2,3-Triazole-containing hybrids with potential antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA). |
| AID1710572 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus ATCC 6538 assessed as inhibition of visible bacterial growth incubated for 18 to 20 hrs by CLSI method | 2020 | RSC medicinal chemistry, Jan-01, Volume: 11, Issue:1 | Potent trifluoromethoxy, trifluoromethylsulfonyl, trifluoromethylthio and pentafluorosulfanyl containing (1,3,4-oxadiazol-2-yl)benzamides against drug-resistant Gram-positive bacteria. |
| AID308730 | Antibacterial activity against Heamophilus influenzae HI3542 by microbroth method | 2007 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 17, Issue:16 | Synthesis and SAR of novel conformationally-restricted oxazolidinones possessing gram-positive and fastidious gram-negative antibacterial activity. Part 1: Substituted pyrazoles. |
| AID211460 | Inhibitory activity against Escherichia coli Topoisomerase IV in relaxation assay; Not tested | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | Structure-activity relationship in the oxazolidinone-quinolone hybrid series: influence of the central spacer on the antibacterial activity and the mode of action. |
| AID318363 | Cytotoxicity against human HeLa cells by MTT assay | 2007 | Proceedings of the National Academy of Sciences of the United States of America, May-01, Volume: 104, Issue:18 | Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties. |
| AID1519267 | Antibacterial activity agianst methicillin-sensitive Staphylococcus aureus clinical isolates | 2019 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 29, Issue:23 | Synthesis and antibacterial evaluation of novel oxazolidinone derivatives containing a piperidinyl moiety. |
| AID1350033 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus isolate 4 incubated overnight by agar dilution method | 2018 | Journal of natural products, 02-23, Volume: 81, Issue:2 | Biomimetic Stereoselective Sulfa-Michael Addition Leads to Platensimycin and Platencin Sulfur Analogues against Methicillin-Resistant Staphylococcus aureus. |
| AID1451756 | Antibacterial activity against Staphylococcus aureus Newman infected in BALB/c mouse assessed as reduction of bacterial burden in heart 0.4 mg, ip bid for 4.5 days administered 6 hrs post bacterial infection measured 108 hrs post infection relative to con | 2017 | Journal of medicinal chemistry, 10-12, Volume: 60, Issue:19 | Novel Inhibitors of Staphyloxanthin Virulence Factor in Comparison with Linezolid and Vancomycin versus Methicillin-Resistant, Linezolid-Resistant, and Vancomycin-Intermediate Staphylococcus aureus Infections in Vivo. |
| AID535034 | Antimicrobial activity against vancomycin intermediate Staphylococcus aureus NRS-126 expressing SCCmec type 2 element by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | In vitro activity of ceftaroline against community-associated methicillin-resistant, vancomycin-intermediate, vancomycin-resistant, and daptomycin-nonsusceptible Staphylococcus aureus isolates. |
| AID67729 | Minimum inhibitory concentration (MIC) against Enterococcus faecalis ATCC 29212 | 2004 | Bioorganic & medicinal chemistry letters, Jun-21, Volume: 14, Issue:12 | The synthesis and antimicrobial evaluation of a new series of isoxazolinyl oxazolidinones. |
| AID1407928 | Antibacterial activity against Haemophilus influenzae ATCC 49247 after 24 hrs by broth microdilution method | 2018 | European journal of medicinal chemistry, Sep-05, Volume: 157 | Discovery of dual GyrB/ParE inhibitors active against Gram-negative bacteria. |
| AID729215 | Antibacterial activity against linezolid-resistant Enterococcus faecium after 16 hrs by NCCLS agar dilution method | 2013 | Journal of medicinal chemistry, Mar-28, Volume: 56, Issue:6 | Solubility-driven optimization of (pyridin-3-yl) benzoxazinyl-oxazolidinones leading to a promising antibacterial agent. |
| AID520236 | Antimicrobial activity against Enterococcus faecium A6349 | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID1180573 | Antimicrobial activity against 2 times drug resistance selected Staphylococcus aureus ARC1692-1F by broth microdilution/CLSI method | 2014 | Journal of medicinal chemistry, Jul-24, Volume: 57, Issue:14 | Optimization of pyrrolamide topoisomerase II inhibitors toward identification of an antibacterial clinical candidate (AZD5099). |
| AID1311367 | Antibacterial activity against Mycobacterium tuberculosis 115R measured after 14 days by broth microdilution assay | 2016 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15 | An evolved oxazolidinone with selective potency against Mycobacterium tuberculosis and gram positive bacteria. |
| AID396033 | Antibacterial activity against drug-resistant AcrAB-TolC efflux pump deficient Enterobacter cloacae EcdeltaacrA isolate expressing pBGS18 plasmid by Etest | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Cloning, nucleotide sequencing, and analysis of the AcrAB-TolC efflux pump of Enterobacter cloacae and determination of its involvement in antibiotic resistance in a clinical isolate. |
| AID533660 | Antimicrobial activity against Staphylococcus aureus RN4220 harboring plasmid VGA | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic characterization of Vga ABC proteins conferring reduced susceptibility to pleuromutilins in Staphylococcus aureus. |
| AID326520 | T>MIC in Enterococcus faecalis infected Wistar rat at 600 mg, po two consecutive administration every 12 hrs | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Single-dose oral amoxicillin or linezolid for prophylaxis of experimental endocarditis due to vancomycin-susceptible and vancomycin-resistant Enterococcus faecalis. |
| AID775544 | Antibacterial activity against Haemophilus influenzae SR27914 clinical isolate assessed as growth inhibition by broth microdilution method | 2013 | European journal of medicinal chemistry, Nov, Volume: 69 | Synthesis and in vitro/in vivo antibacterial activity of oxazolidinones having thiocarbamate at C-5 on the A-ring and an amide- or urea-substituted [1,2,5]triazepane or [1,2,5]oxadiazepane as the C-ring. |
| AID1574842 | Antibacterial activity against clinical isolates of vancomycin-resistant Enterococcus faecium by broth liquid microdilution method | 2019 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 29, Issue:3 | Design and synthesis of biaryloxazolidinone derivatives containing a rhodanine or thiohydantoin moiety as novel antibacterial agents against Gram-positive bacteria. |
| AID576893 | Ratio of Cmax to MIC for 12.5 hrs peripheral compartment culture samples of Enterococcus faecalis Ef1497 in two-compartment pharmacokinetic/pharmacodynamic model at 800 mg, bid administered as 0.5 hr infusion for 2 days | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID576656 | Bactericidal activity against 48 hrs peripheral compartment culture samples of Enterococcus faecalis ATCC 29212 in two-compartment pharmacokinetic/pharmacodynamic model assessed as effect on bacterial count at 200 mg, bid administered as 0.5 hr infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID577128 | Terminal half-life in two-compartment pharmacokinetic/pharmacodynamic model at 600 mg, bid administered as 0.5 hr infusion over 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID475005 | Antibacterial activity against Escherichia coli LCB0010 by two fold serial dilution method | 2010 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 20, Issue:7 | Synthesis, crystal and antibacterial studies of diversely functionalized tetrahydropyridin-4-ol. |
| AID1853631 | Inhibition of protein synthesis in Staphylococcus aureus ATCC 29213 at 8 times MIC preincubated for 30 mins followed by [3H]-leucine and measured after 40 mins by [3H]-leucine incorporation based beta scintillation counter analysis | 2021 | RSC medicinal chemistry, Oct-20, Volume: 12, Issue:10 | Design, synthesis, and antibacterial activity of |
| AID577113 | ABBC (0 to 24 hrs) in Enterococcus faecalis ATCC 29212 in two-compartment pharmacokinetic/pharmacodynamic model at 600 mg, bid administered as 0.5 hr infusion for 2 days | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID125103 | Antibacterial activity against Moraxella catarrhalis | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | Iclaprim, a novel diaminopyrimidine with potent activity on trimethoprim sensitive and resistant bacteria. |
| AID1596894 | Antibacterial activity against Staphylococcus aureus ATCC 29213 incubated for 16 to 18 hrs by broth microdilution assay | |||
| AID544830 | Antimicrobial activity against Staphylococcus epidermidis Xen 43 biofilm assessed as log10 CFU/cm'2 in bacterial count in presence of 200 microamperes of electric current by bioelectric effect assay | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Effect of electrical current on the activities of antimicrobial agents against Pseudomonas aeruginosa, Staphylococcus aureus, and Staphylococcus epidermidis biofilms. |
| AID572485 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus NB01021 infected in po dosed BALB/c mouse administered 0, 4, 23 hrs post infection | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vivo characterization of the peptide deformylase inhibitor LBM415 in murine infection models. |
| AID1778662 | Bactericidal activity against penicillin-susceptible Bacillus pumilus CMCC 63202 measured after 24 hrs by CLSI protocol based method | 2021 | European journal of medicinal chemistry, Oct-05, Volume: 221 | Design, synthesis and evaluation of novel 9-arylalkyl-10-methylacridinium derivatives as highly potent FtsZ-targeting antibacterial agents. |
| AID763987 | Antibacterial activity against methicillin-resistant Staphylococcus aureus after 18 hrs by NCCLS agar dilution method | 2013 | European journal of medicinal chemistry, Aug, Volume: 66 | Synthesis and antibacterial activities of N-substituted-glycinyl 1H-1,2,3-triazolyl oxazolidinones. |
| AID555743 | Antibacterial activity against methicillin-resistant, vancomycin-intermediate coagulase-negative Staphylococcus epidermidis 225 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Antistaphylococcal activity of dihydrophthalazine antifolates, a family of novel antibacterial drugs. |
| AID134115 | Protective dose of orally administered compound against intraperitoneally-induced septicaemia model (Enterococci faecium D3HT7 strain) in murine | 2000 | Bioorganic & medicinal chemistry letters, Aug-07, Volume: 10, Issue:15 | Improved antibacterial activities of coumarin antibiotics bearing 5',5'-dialkylnoviose: biological activity of RU79115. |
| AID1400025 | Selectivity ratio of MIC for antibacterial activity against non-replicating Mycobacterium tuberculosis H37Rv harboring pFCA-luxAB to MIC100 for antibacterial activity against replicating Mycobacterium tuberculosis H37Rv | 2018 | Bioorganic & medicinal chemistry, 09-15, Volume: 26, Issue:17 | An antimycobacterial pleuromutilin analogue effective against dormant bacilli. |
| AID1168022 | Antibacterial activity against vancomycin-resistant Enterococcus faecium clinical isolate 16115 after overnight incubation by two-fold serial dilution method | 2014 | Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21 | Synthesis and biological evaluation of novel peptide BF2 as an antibacterial agent against clinical isolates of vancomycin-resistant enterococci. |
| AID562246 | Antibacterial activity against Staphylococcus epidermidis 1653059 harboring rplC G469A/C470G, L3 Ala157Arg and 23S rRNA G2447T mutant by CLSI broth microdilution assay | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Mutations in ribosomal protein L3 are associated with oxazolidinone resistance in staphylococci of clinical origin. |
| AID1059061 | Antibacterial activity against methicillin-resistant Staphylococcus aureus clinical isolate OM584 by liquid microdilution method | 2013 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 23, Issue:24 | Structure-anti-MRSA activity relationship of macrocyclic bis(bibenzyl) derivatives. |
| AID373809 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus 525 after 50 passages by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID552863 | Antibacterial activity against Streptococcus pyogenes infected in po dosed in vivo acute model administered bid for 1 day | 2011 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1 | The discovery and structure-activity relationships leading to CE-156811, a difluorophenyl cyclopropyl fluoroether: a novel potent antibacterial analog derived from hygromycin A. |
| AID609058 | Antibacterial activity against Escherichia coli ATCC 8739 at 1 mg/ml after 24 hrs by agar-well diffusion technique | 2011 | European journal of medicinal chemistry, Jul, Volume: 46, Issue:7 | A regioselective synthesis of some new pyrazol-1'-ylpyrazolo[1,5-a]pyrimidines in aqueous medium and their evaluation as antimicrobial agents. |
| AID205897 | Minimum inhibitory concentration against Staphylococcus epidermidis MTCC 155 | 2004 | Bioorganic & medicinal chemistry letters, Jun-21, Volume: 14, Issue:12 | Oxazolidinone: search for highly potent antibacterial. |
| AID576669 | Bactericidal activity against 12 hrs peripheral compartment culture samples of Enterococcus faecalis Ef1497 in two-compartment pharmacokinetic/pharmacodynamic model assessed as effect on bacterial count at 600 mg, bid administered as 0.5 hr infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID1778100 | Antibacterial activity against Enterococcus faecalis ATCC 29212 assessed as bacterial growth inhibition after 18 hrs by broth microdilution method | |||
| AID533017 | Antibacterial activity against vancomycin-susceptible Staphylococcus aureus N315-LR5-P1-1 assessed as inhibition of bacterial growth in Mueller-Hinton broth medium | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Improved antimicrobial activity of linezolid against vancomycin-intermediate Staphylococcus aureus. |
| AID555316 | Antibacterial activity against methicillin-susceptible, vancomycin-intermediate Staphylococcus aureus 505 after 50 passages by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Antistaphylococcal activity of dihydrophthalazine antifolates, a family of novel antibacterial drugs. |
| AID528706 | Antibacterial activity against Streptococcus agalactiae group B clinical isolate assessed as susceptibility level by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID323790 | Antibacterial activity against methicillin-resistant Staphylococcus aureus Xen1 infected neutropenic CD1 mouse assessed as mortality at 100 mg/kg, po within 24 hrs | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Rapid bactericidal activity of daptomycin against methicillin-resistant and methicillin-susceptible Staphylococcus aureus peritonitis in mice as measured with bioluminescent bacteria. |
| AID285086 | Antimicrobial activity against viridans group Streptococcus constellatus at 0.5 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID1446755 | Bactericidal activity against methicillin-resistant Staphylococcus aureus USA100 NRS382 clinical isolate after 18 hrs by broth microdilution method | 2017 | European journal of medicinal chemistry, Apr-21, Volume: 130 | Diphenylurea derivatives for combating methicillin- and vancomycin-resistant Staphylococcus aureus. |
| AID1680061 | Antibacterial activity against methicillin-resistant Staphylococcus aureus clinical isolate 5 assessed as reduction in bacterial growth incubated for 16 to 20 hrs by CLSI-based broth microdilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Synthesis and antibacterial bioactivities of cationic deacetyl linezolid amphiphiles. |
| AID66574 | Antibacterial activity was determined against clinically isolated vancomycin-B resistant enterococci (VRE) strains (10 strains) | 2003 | Journal of medicinal chemistry, Mar-13, Volume: 46, Issue:6 | Synthesis and structure-activity relationships of 5-amino-6-fluoro-1-[(1R,2S)-2-fluorocyclopropan-1-yl]-8-methylquinolonecarboxylic acid antibacterials having fluorinated 7-[(3R)-3-(1-aminocyclopropan-1-yl)pyrrolidin-1-yl] substituents. |
| AID284947 | Antimicrobial activity against Bacillus spp. at 0.25 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID1126491 | Antimicrobial activity against Haemophilus influenzae ATCC 31517 MMSA | 2014 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 24, Issue:8 | Synthesis, antibiotic activity and structure-activity relationship study of some 3-enaminetetramic acids. |
| AID1271226 | Antibacterial activity against pencillin-resistant erm+ve Streptococcus pneumoniae ATCC 700904 by microbroth dilution method | 2015 | ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11 | Design, Synthesis, and Identification of Silicon Incorporated Oxazolidinone Antibiotics with Improved Brain Exposure. |
| AID520019 | Antimicrobial activity against Staphylococcus aureus pLXM1 harboring cfr gene | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID303918 | Antibacterial activity against methicillin-resistant Staphylococcus aureus 562 infected orally dosed Swiss albino mouse after 7 days | 2007 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 17, Issue:24 | Synthesis and antibacterial activity of potent heterocyclic oxazolidinones and the identification of RBx 8700. |
| AID576407 | Mean residence time in two-compartment pharmacokinetic/pharmacodynamic model at 800 mg, bid administered as 0.5 hrs infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID370030 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus Smith infected in C3H mouse assessed as renal sterilization at 25 mg/kg/day, po administered 15 mins postinfection | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vivo efficacy of a novel oxazolidinone compound in two mouse models of infection. |
| AID373318 | Antibacterial activity against Enterococcus faecalis ATCC 29212 after 18 hrs by NCCLS M7-A4 method | 2009 | European journal of medicinal chemistry, Mar, Volume: 44, Issue:3 | Synthesis, antibacterial and anticonvulsant evaluations of some cyclic enaminones. |
| AID1653062 | Antibacterial activity against Staphylococcus epidermidis | 2019 | European journal of medicinal chemistry, Feb-15, Volume: 164 | Isatin derivatives and their anti-bacterial activities. |
| AID763978 | Antibacterial activity against Moraxella catarrhalis ATCC 8176 after 18 hrs by NCCLS agar dilution method | 2013 | European journal of medicinal chemistry, Aug, Volume: 66 | Synthesis and antibacterial activities of N-substituted-glycinyl 1H-1,2,3-triazolyl oxazolidinones. |
| AID1596571 | Bactericidal activity against Cephalosporin resistant Streptococcus pneumoniae ATCC 51916 assessed as reduction in bacterial cell growth incubated for 18 to 20 hrs followed by re-plating on tryptic soy agar plates at 37 degC for 18 hrs by broth microdilut | 2019 | European journal of medicinal chemistry, Aug-01, Volume: 175 | Lipophilic efficient phenylthiazoles with potent undecaprenyl pyrophosphatase inhibitory activity. |
| AID370019 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus Smith infected in C3H mouse assessed as eradication at 25 mg/kg/day, iv administered within 15 mins of infection assessed per gram of kidney measured after 48 hrs by organ burden | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vivo efficacy of a novel oxazolidinone compound in two mouse models of infection. |
| AID66576 | Antibacterial activity was determined against clinically isolated vancomycin-A resistant enterococci (VRE) strains (33 strains) | 2003 | Journal of medicinal chemistry, Mar-13, Volume: 46, Issue:6 | Synthesis and structure-activity relationships of 5-amino-6-fluoro-1-[(1R,2S)-2-fluorocyclopropan-1-yl]-8-methylquinolonecarboxylic acid antibacterials having fluorinated 7-[(3R)-3-(1-aminocyclopropan-1-yl)pyrrolidin-1-yl] substituents. |
| AID1197131 | Antibacterial activity against vancomycin-resistant Enterococcus faecium 119-39A clinical isolate after 16 to 20 hrs by broth microdilution method | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3 | Structure-activity relationship for the oxadiazole class of antibiotics. |
| AID268862 | Antibacterial activity against Staphylococcus aureus ATCC 49951 | 2006 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 16, Issue:16 | Synthesis of novel tricyclic oxazolidinones by a tandem SN2 and SNAr reaction: SAR studies on conformationally constrained analogues of Linezolid. |
| AID577105 | AUBC (0 to 24 hrs) in Enterococcus faecalis ATCC 29212 in two-compartment pharmacokinetic/pharmacodynamic model at 600 mg, bid administered as 0.5 hr infusion for 2 days | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID287260 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus by agar dilution method | 2007 | European journal of medicinal chemistry, Feb, Volume: 42, Issue:2 | Structure-antibacterial activity of arylcarbonyl- and arylsulfonyl-piperazine 5-triazolylmethyl oxazolidinones. |
| AID745374 | Inhibition of MAO-A in rat forebrain using [14C]5-HT as substrate at 30 uM incubated for 20 mins prior to substrate addition measured after 5 mins by liquid scintillation counting analysis relative to control | 2013 | European journal of medicinal chemistry, May, Volume: 63 | Antibacterial oxazolidinone analogues having a N-hydroxyacetyl-substituted seven-membered [1,2,5]triazepane or [1,2,5]oxadiazepane C-ring unit. |
| AID1647980 | Antibacterial activity against Escherichia coli by resazurin dye based microdilution method | 2020 | Journal of natural products, 02-28, Volume: 83, Issue:2 | The Isolation of Pyrroloformamide Congeners and Characterization of Their Biosynthetic Gene Cluster. |
| AID304006 | Effect on hematology in Sprague-Dawley rat assessed as increase in hematocrit at 200 mg/kg/day, po after 14 days | 2007 | Journal of medicinal chemistry, Nov-29, Volume: 50, Issue:24 | Antibacterial oxazolidinones possessing a novel C-5 side chain. (5R)-trans-3-[3-Fluoro-4- (1-oxotetrahydrothiopyran-4-yl)phenyl]-2- oxooxazolidine-5-carboxylic acid amide (PF-00422602), a new lead compound. |
| AID373989 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus 525 after 20 passages with daptomycin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID573137 | Antibacterial activity against erythromycin-susceptible Streptococcus agalactiae assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID134124 | Protective dose of subcutaneously administered compound against intraperitoneally-induced septicaemia model (Staphylococcus pneumoniae PW3 strain) in murine | 2000 | Bioorganic & medicinal chemistry letters, Aug-07, Volume: 10, Issue:15 | Improved antibacterial activities of coumarin antibiotics bearing 5',5'-dialkylnoviose: biological activity of RU79115. |
| AID577109 | AUBC (0 to 24 hrs) in Enterococcus faecalis Ef1497 MutM3 in two-compartment pharmacokinetic/pharmacodynamic model at 600 mg, bid administered as 0.5 hr infusion for 2 days | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID763948 | Antibacterial activity against Moraxella catarrhalis clinical isolate 3447 after 18 hrs by NCCLS agar dilution method | 2013 | European journal of medicinal chemistry, Aug, Volume: 66 | Synthesis and antibacterial activities of N-substituted-glycinyl 1H-1,2,3-triazolyl oxazolidinones. |
| AID349314 | Antibacterial activity against Haemophilus influenzae clinical isolate after 18 hrs by agar dilution method | 2008 | European journal of medicinal chemistry, May, Volume: 43, Issue:5 | Synthesis and structure-antibacterial activity of triazolyl oxazolidinones containing long chain acyl moiety. |
| AID285139 | Antimicrobial activity against viridans group Streptococcus vestibularis at 0.5 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID541052 | Ratio of AUC (0 to 24 hrs) to MIC for methicillin-resistant Staphylococcus aureus ATCC 43300 in Albino guiena pig model of foreign-body infection at 50 mg/kg, ip | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Linezolid alone or combined with rifampin against methicillin-resistant Staphylococcus aureus in experimental foreign-body infection. |
| AID1180586 | Ratio of MIC for 2 times drug resistance selected Staphylococcus aureus ARC2381-3F to MIC for Staphylococcus aureus ARC2381 | 2014 | Journal of medicinal chemistry, Jul-24, Volume: 57, Issue:14 | Optimization of pyrrolamide topoisomerase II inhibitors toward identification of an antibacterial clinical candidate (AZD5099). |
| AID533006 | Antibacterial activity against vancomycin-intermediate Staphylococcus aureus 99/3759-V phenotypic revertant after 24 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Improved antimicrobial activity of linezolid against vancomycin-intermediate Staphylococcus aureus. |
| AID345138 | Antimicrobial activity against Haemophilus influenzae RD1 by NCCLS method | 2008 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 18, Issue:23 | Design at the atomic level: generation of novel hybrid biaryloxazolidinones as promising new antibiotics. |
| AID292902 | Antimicrobial activity against streptococcus pneumoniae by broth dilution method | 2007 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 17, Issue:2 | New carbon-linked azole oxazolidinones with improved potency and pharmacokinetics. |
| AID1190640 | Antibacterial activity against Escherichia coli NCIM-2256 incubated for 24 hrs by two fold serial dilution method | 2015 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 25, Issue:4 | Biofilm inhibition of linezolid-like Schiff bases: synthesis, biological activity, molecular docking and in silico ADME prediction. |
| AID630563 | Antibacterial activity against Staphylococcus aureus ATCC 19636 infected in mouse systemic infection model administered orally 1 hour after infection measured 48 hrs of post-treatment | 2011 | Journal of medicinal chemistry, Nov-10, Volume: 54, Issue:21 | Design, synthesis, and structure-activity relationship studies of highly potent novel benzoxazinyl-oxazolidinone antibacterial agents. |
| AID687493 | Oral bioavailability in rat | 2012 | Bioorganic & medicinal chemistry, Oct-15, Volume: 20, Issue:20 | Antitubercular nitrofuran isoxazolines with improved pharmacokinetic properties. |
| AID1126488 | Antimicrobial activity against vancomycin-susceptible Enterococcus faecalis ATCC 29212 | 2014 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 24, Issue:8 | Synthesis, antibiotic activity and structure-activity relationship study of some 3-enaminetetramic acids. |
| AID1594386 | Cmax in human at 625 mg, iv | 2019 | Bioorganic & medicinal chemistry, 05-01, Volume: 27, Issue:9 | Second-generation aryl isonitrile compounds targeting multidrug-resistant Staphylococcus aureus. |
| AID567450 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus CGK2 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Development of daptomycin nonsusceptibility with heterogeneous vancomycin-intermediate resistance and oxacillin susceptibility in methicillin-resistant Staphylococcus aureus during high-dose daptomycin treatment. |
| AID29429 | Oral bioavailability in rat (Sprague-Dawley) (male) (dose 25 mg/kg p.o.) | 2003 | Journal of medicinal chemistry, Jan-16, Volume: 46, Issue:2 | Identification of phenylisoxazolines as novel and viable antibacterial agents active against Gram-positive pathogens. |
| AID370026 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus Smith infected in C3H mouse assessed as reduction in log number of CFU at 3.12 mg/kg/day, iv administered within 15 mins of infection measured after 48 hrs by organ burden assay | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vivo efficacy of a novel oxazolidinone compound in two mouse models of infection. |
| AID1472763 | In vivo anti-virulence activity against Staphylococcus aureus Mu50 infected in BALB/c mouse model assessed as reduction in bacterial load in kidney at 0.4 mg bid for 4.5 days administered orally 6 hrs post infection by serial dilution method relative to c | 2018 | Journal of medicinal chemistry, 01-11, Volume: 61, Issue:1 | Novel Terminal Bipheny-Based Diapophytoene Desaturases (CrtN) Inhibitors as Anti-MRSA/VISR/LRSA Agents with Reduced hERG Activity. |
| AID319986 | Antimicrobial activity against vancomycin-resistant Enterococcus faecium ATCC 12202 | 2008 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 18, Issue:2 | Synthesis, SAR, and antibacterial activity of novel oxazolidinone analogues possessing urea functionality. |
| AID1076820 | Antitubercular activity against extensive drug-resistant Mycobacterium tuberculosis clinical isolate 5 assessed as growth inhibition by microdilution method | 2014 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 24, Issue:6 | Discovery of novel bis-oxazolidinone compounds as potential potent and selective antitubercular agents. |
| AID285089 | Antimicrobial activity against viridans group Streptococcus gordonii at <= 0.06 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID392200 | Antibacterial activity against Escherichia coli by transcription-translation assay | 2009 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 19, Issue:2 | Synthesis and structure-activity studies of novel homomorpholine oxazolidinone antibacterial agents. |
| AID67086 | Antibacterial activity against Enterococcus faecalis UC9217 | 1998 | Bioorganic & medicinal chemistry letters, May-19, Volume: 8, Issue:10 | Synthesis and antibacterial activity of [6,5,5] and [6,6,5] tricyclic fused oxazolidinones. |
| AID458453 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus 143/93 at 2 mM after overnight incubation by agar diffusion method | 2010 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 20, Issue:3 | Syntheses and antibacterial activity studies of new oxazolidinones from nitroso Diels-Alder chemistry. |
| AID245424 | Minimum inhibitory concentration against methicillin resistant Staphylococcus aureus (strain A27223) in presence of 50% calf serum | 2004 | Bioorganic & medicinal chemistry letters, Sep-20, Volume: 14, Issue:18 | Discovery of isoxazolinone antibacterial agents. Nitrogen as a replacement for the stereogenic center found in oxazolidinone antibacterials. |
| AID575143 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus isolate NRS70 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Inhibition of antibiotic-resistant Staphylococcus aureus by the broad-spectrum dihydrofolate reductase inhibitor RAB1. |
| AID1501369 | Bactericidal activity against vancomycin-resistant Staphylococcus aureus isolate 10 incubated for 20 hrs followed by replating on tryptic soy agar plates and further incubated for 18 hrs by broth microdilution assay | 2017 | European journal of medicinal chemistry, Oct-20, Volume: 139 | Arylthiazole antibiotics targeting intracellular methicillin-resistant Staphylococcus aureus (MRSA) that interfere with bacterial cell wall synthesis. |
| AID535027 | Antimicrobial activity against vancomycin intermediate Staphylococcus aureus NRS-27 expressing SCCmec type 2 element by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | In vitro activity of ceftaroline against community-associated methicillin-resistant, vancomycin-intermediate, vancomycin-resistant, and daptomycin-nonsusceptible Staphylococcus aureus isolates. |
| AID576437 | Bactericidal activity against 0.5 hrs peripheral compartment culture samples of Staphylococcus aureus RN4220 MutS2 in two-compartment pharmacokinetic/pharmacodynamic model assessed as effect on bacterial count at 600 mg, bid administered as 0.5 hr infusio | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID1877887 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae DSM-11865 assessed as bacterial growth inhibition | 2022 | Bioorganic & medicinal chemistry letters, 03-01, Volume: 59 | Novel 2,4-disubstituted quinazoline analogs as antibacterial agents with improved cytotoxicity profile: Modification of the benzenoid part. |
| AID710137 | Antibacterial activity against methicillin-resistant Staphylococcus epidermidis | 2012 | Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22 | From triclosan toward the clinic: discovery of nonbiocidal, potent FabI inhibitors for the treatment of resistant bacteria. |
| AID520222 | Antimicrobial activity against Enterococcus faecium A9650 | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID1474208 | Bactericidal activity against Enterococcus faecium after 18 to 22 hrs by broth microdilution method | 2017 | Journal of medicinal chemistry, 03-23, Volume: 60, Issue:6 | Phenylthiazole Antibacterial Agents Targeting Cell Wall Synthesis Exhibit Potent Activity in Vitro and in Vivo against Vancomycin-Resistant Enterococci. |
| AID1539445 | Antibacterial activity against linezolid-resistant/Methicillin-resistant Staphylococcus aureus NRS119 clinical isolates after 18 to 20 hrs in aerobic condition by CLSI protocol based broth microdilution assay | |||
| AID260740 | Antibacterial activity against methicillin resistant Staphylococcus aureus MRSA 1094 | 2006 | Journal of medicinal chemistry, Feb-23, Volume: 49, Issue:4 | Hybrid antibacterials. DNA polymerase-topoisomerase inhibitors. |
| AID283168 | Antimicrobial susceptibility of Staphylococcus lugdunensis IDRL5256 biofilms after 24 hrs assessed as bacterial regrowth | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | In vitro effects of antimicrobial agents on planktonic and biofilm forms of Staphylococcus lugdunensis clinical isolates. |
| AID370036 | Antibacterial activity against methicillin-resistant Staphylococcus aureus COL infected in po dosed DBA/2 mouse localized infection model assessed as log reduction in CFU per gram of thigh at 10 mg/kg, iv administered 2 hrs postinfection thrice daily for | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vivo efficacy of a novel oxazolidinone compound in two mouse models of infection. |
| AID285058 | Antimicrobial activity against beta hemolytic Streptococcus group C at 2 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID285098 | Antimicrobial activity against viridans group Streptococcus intermedius at 1 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID374018 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus 547 after single-step resistance selection by agar dilution CLSI method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID284999 | Antimicrobial activity against Enterococcus durans at 2 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID532805 | Antibacterial activity against vancomycin-susceptible Staphylococcus aureus LIM2 after 24 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Improved antimicrobial activity of linezolid against vancomycin-intermediate Staphylococcus aureus. |
| AID576397 | Tmax in two-compartment pharmacokinetic/pharmacodynamic model at 600 mg, bid administered as 0.5 hrs infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID1400054 | Bactericidal activity against Klebsiella pneumoniae ATCC 12019 incubated for 24 hrs under aerobic condition by MABA | 2018 | Bioorganic & medicinal chemistry, 09-15, Volume: 26, Issue:17 | An antimycobacterial pleuromutilin analogue effective against dormant bacilli. |
| AID560375 | Selectivity ratio of MIC for Enterococcus faecium ATCC 51559 in presence of 4% HSA to MIC for Enterococcus faecium ATCC 51559 | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Impact of human serum albumin on oritavancin in vitro activity against enterococci. |
| AID1687310 | Antibacterial activity against Klebsiella pneumoniae ATCC 1706 incubated for 18 to 20 hrs by broth microdilution method | 2020 | European journal of medicinal chemistry, Jan-15, Volume: 186 | Development of benzimidazole-based derivatives as antimicrobial agents and their synergistic effect with colistin against gram-negative bacteria. |
| AID1584838 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis JH2-2::C1 after 18 to 24 hrs by microdilution assay | 2018 | European journal of medicinal chemistry, Nov-05, Volume: 159 | 1-(2-Hydroxybenzoyl)-thiosemicarbazides are promising antimicrobial agents targeting d-alanine-d-alanine ligase in bacterio. |
| AID574546 | Antimicrobial activity against community-associated methicillin-resistant Staphylococcus aureus Sanger 252 | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Subinhibitory concentrations of protein synthesis-inhibiting antibiotics promote increased expression of the agr virulence regulator and production of phenol-soluble modulin cytolysins in community-associated methicillin-resistant Staphylococcus aureus. |
| AID283641 | Antimicrobial activity against Staphylococcus aureus RN4220 deltamutS | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | In vitro activity of the oxazolidinone RWJ-416457 against linezolid-resistant and -susceptible staphylococci and enterococci. |
| AID1904080 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 | 2022 | European journal of medicinal chemistry, Apr-05, Volume: 233 | Alternative approaches utilizing click chemistry to develop next-generation analogs of solithromycin. |
| AID439895 | Cytotoxicity against mouse NIH/3T3 cells after 24 hrs by MTT assay | 2010 | European journal of medicinal chemistry, Jan, Volume: 45, Issue:1 | Synthesis and antibacterial activity of isothiazolyl oxazolidinones and analogous 3(2H)-isothiazolones. |
| AID542712 | fT>MIC in Bacillus anthracis infected in vitro hollow fiber PK/PD model at simulated dose of 500 mg /day administered as 6 divided doses every 4 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID729222 | Antibacterial activity against methicillin-resistant Staphylococcus epidermidis after 16 hrs by NCCLS agar dilution method | 2013 | Journal of medicinal chemistry, Mar-28, Volume: 56, Issue:6 | Solubility-driven optimization of (pyridin-3-yl) benzoxazinyl-oxazolidinones leading to a promising antibacterial agent. |
| AID1770360 | Ratio of MBC to MIC against penicillin-susceptible Bacillus pumilus CMCC63202 | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Modification of 5-methylphenanthridium from benzothiazoles to indoles as potent FtsZ inhibitors: Broadening the antibacterial spectrum toward vancomycin-resistant enterococci. |
| AID576679 | Bactericidal activity against 12.5 hrs peripheral compartment culture samples of Enterococcus faecalis Ef1497 in two-compartment pharmacokinetic/pharmacodynamic model assessed as effect on bacterial count at 800 mg, bid administered as 0.5 hr infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID542690 | fT>MIC in Bacillus anthracis infected in vitro hollow fiber PK/PD model at simulated dose of 300 mg administered every 24 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID1168026 | Antibacterial activity against vancomycin-resistant Enterococcus faecium clinical isolate 18906 after overnight incubation by two-fold serial dilution method | 2014 | Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21 | Synthesis and biological evaluation of novel peptide BF2 as an antibacterial agent against clinical isolates of vancomycin-resistant enterococci. |
| AID1395679 | Antibacterial activity against methicillin-resistant Staphylococcus aureus NRS386 after 18 hrs by broth microdilution assay | 2018 | European journal of medicinal chemistry, May-10, Volume: 151 | Phenylthiazoles with tert-Butyl side chain: Metabolically stable with anti-biofilm activity. |
| AID1778091 | Antibacterial activity against Staphylococcus aureus ATCC 29213 assessed as inhibition of bacterial growth incubated for 18 hrs by broth microdilution method | |||
| AID1435933 | Bactericidal activity against vancomycin-resistant Staphylococcus aureus VRSA4 clinical isolate after 24 hrs | 2017 | European journal of medicinal chemistry, Jan-27, Volume: 126 | Phenylthiazole antibiotics: A metabolism-guided approach to overcome short duration of action. |
| AID285084 | Antimicrobial activity against viridans group Streptococcus constellatus at 0.12 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID1519272 | Antibacterial activity agianst methicillin-sensitive Staphylococcus aureus | 2019 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 29, Issue:23 | Synthesis and antibacterial evaluation of novel oxazolidinone derivatives containing a piperidinyl moiety. |
| AID308726 | Antibacterial activity against Staphylococcus aureus UC76 SA1 by micro-broth method | 2007 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 17, Issue:16 | Synthesis and SAR of novel conformationally-restricted oxazolidinones possessing gram-positive and fastidious gram-negative antibacterial activity. Part 1: Substituted pyrazoles. |
| AID1710584 | Antibacterial activity against vancomycin-resistant Staphylococcus aureus 10 assessed as inhibition of visible bacterial growth incubated for 18 to 20 hrs by CLSI method | 2020 | RSC medicinal chemistry, Jan-01, Volume: 11, Issue:1 | Potent trifluoromethoxy, trifluoromethylsulfonyl, trifluoromethylthio and pentafluorosulfanyl containing (1,3,4-oxadiazol-2-yl)benzamides against drug-resistant Gram-positive bacteria. |
| AID575100 | Antimicrobial activity against Streptococcus pneumoniae serotype 22F assessed as percent susceptible isolates by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID1361050 | Antibacterial activity against methicillin-resistant Staphylococcus aureus BAA-1707 after 16 to 18 hrs by broth microdilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Halogenated quinolines bearing polar functionality at the 2-position: Identification of new antibacterial agents with enhanced activity against Staphylococcus epidermidis. |
| AID560806 | AUC (0 to 24 hrs) at steady state in human adults with pulmonary tuberculosis at 600 mg administered daily for 7 days | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Population pharmacokinetics of linezolid in adults with pulmonary tuberculosis. |
| AID1596551 | Antibacterial activity against methicillin resistant Staphylococcus epidermidis NRS101 assessed as reduction in bacterial cell growth incubated for 18 to 20 hrs by broth microdilution method | 2019 | European journal of medicinal chemistry, Aug-01, Volume: 175 | Lipophilic efficient phenylthiazoles with potent undecaprenyl pyrophosphatase inhibitory activity. |
| AID207682 | Minimum inhibitory concentration (MIC) against methicillin-resistant Staphylococcus aureus (MRSA) OC2878 | 2004 | Bioorganic & medicinal chemistry letters, Jun-21, Volume: 14, Issue:12 | The synthesis and antimicrobial evaluation of a new series of isoxazolinyl oxazolidinones. |
| AID520483 | Toxicity in methicillin-resistant Staphylococcus aureus-infected New Zealand rabbit osteomyelitis model assessed as body weight at 30 mg/kg, sc administered every 12 hrs for 4 days measured on week 4 postinfection (Rvb = 2.84 +/- 0.30 kg) | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Efficacies of ceftobiprole medocaril and comparators in a rabbit model of osteomyelitis due to methicillin-resistant Staphylococcus aureus. |
| AID424767 | Antibacterial activity against vancomycin, linezolid-resistant Enterococcus faecium CL5791 after 20 hrs by twofold serial broth dilution method in presence of 50% human serum | 2009 | Journal of natural products, May-22, Volume: 72, Issue:5 | Thiazomycins, thiazolyl peptide antibiotics from Amycolatopsis fastidiosa. |
| AID1649279 | Antibacterial activity against Staphylococcus aureus SMITH assessed as inhibition of bacterial growth incubated for 20 hrs by microdilution broth method | |||
| AID1649289 | Antibacterial activity against Vancomycin-resistant Enterococcus faecium SR23598 (VanB) assessed as inhibition of bacterial growth incubated for 20 hrs by microdilution broth method | |||
| AID560576 | Bactericidal activity against vancomycin-resistant Enterococcus faecalis ATCC 51299 expressing vanB gene assessed as change in bacterial count at 16 ug/ml by time-kill assay | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Impact of human serum albumin on oritavancin in vitro activity against enterococci. |
| AID569347 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae by agar dilution method | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 | Design, synthesis and antibacterial activity of 3-methylenepyrrolidine formyl hydroxyamino derivatives as novel peptide deformylase inhibitors. |
| AID575076 | Antimicrobial activity against Streptococcus pneumoniae serotype 19A assessed as percent susceptible isolates by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID1446763 | Bactericidal activity against vancomycin-resistant Staphylococcus aureus VRSA10 after 18 hrs by broth microdilution method | 2017 | European journal of medicinal chemistry, Apr-21, Volume: 130 | Diphenylurea derivatives for combating methicillin- and vancomycin-resistant Staphylococcus aureus. |
| AID541044 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 infected in Albino guiena pig assessed as decrease in planktonic bacterial counts in cage fluid at 25 mg/kg after measured on day 10 postinfection | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Linezolid alone or combined with rifampin against methicillin-resistant Staphylococcus aureus in experimental foreign-body infection. |
| AID558493 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus 525 measured on day 15 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID368291 | Bactericidal activity against vancomycin-intermediate Staphylococcus aureus in rabbit endocarditis model assessed as growth inhibition at 58 mg/kg infused every 12 hrs for 4 days measured after 48 hrs | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vivo efficacy of ceftaroline (PPI-0903), a new broad-spectrum cephalosporin, compared with linezolid and vancomycin against methicillin-resistant and vancomycin-intermediate Staphylococcus aureus in a rabbit endocarditis model. |
| AID542911 | Antimicrobial activity against Bacillus anthracis infected in in vitro hollow fiber PK/PD model assessed as cell killing at 300 mg administered once every 24 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID576862 | Bactericidal activity against 24 hrs peripheral compartment culture samples of Enterococcus faecalis Ef1497 in two-compartment pharmacokinetic/pharmacodynamic model assessed as effect on bacterial count at 800 mg, bid administered as 0.5 hr infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID604292 | Antibacterial activity against vancomycin-resistant Enterococcus faecium after 16 to 24 hrs by twofold serial dilution method | 2011 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 21, Issue:14 | 7-Alkyl-N(2)-substituted-3-deazaguanines. Synthesis, DNA polymerase III inhibition and antibacterial activity. |
| AID523788 | Antimicrobial activity against oxacillin-resistant Staphylococcus aureus assessed as inhibition of microbial growth at 4 ug/ml by CLSI method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative activities of TR-700 (torezolid) against staphylococcal blood isolates collected in Spain. |
| AID283395 | Antimicrobial activity against Nocardia nova after 72 hrs by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | In vitro activities of tigecycline and eight other antimicrobials against different Nocardia species identified by molecular methods. |
| AID125104 | Inhibitory activity against Moraxella catarrhalis | 1996 | Journal of medicinal chemistry, Sep-27, Volume: 39, Issue:20 | New directions in antibacterial research. |
| AID1877886 | Antibacterial activity against Streptococcus pneumoniae DSM-20566 assessed as bacterial growth inhibition | 2022 | Bioorganic & medicinal chemistry letters, 03-01, Volume: 59 | Novel 2,4-disubstituted quinazoline analogs as antibacterial agents with improved cytotoxicity profile: Modification of the benzenoid part. |
| AID577133 | AUC in two-compartment pharmacokinetic/pharmacodynamic model at 200 mg, bid administered as 0.5 hr infusion over 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID1474167 | Liver toxicity in human assessed as induction of drug-induced liver injury by measuring verified drug-induced liver injury concern status | 2016 | Drug discovery today, Apr, Volume: 21, Issue:4 | DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. |
| AID645047 | Antibacterial activity against Serratia marcescens Mel 522 after 16 to 20 hrs by microbroth dilution method | 2012 | European journal of medicinal chemistry, Apr, Volume: 50 | Synthesis and preliminary antibacterial evaluation of Linezolid-like 1,2,4-oxadiazole derivatives. |
| AID726199 | Antibacterial activity against methicillin-resistant coagulase negative Staphylococcus by agar dilution method | 2013 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 23, Issue:5 | Synthesis and antibacterial activities of new piperidine substituted (5R)-[1,2,3]triazolylmethyl and (5R)-[(4-F-[1,2,3]triazolyl)methyl] oxazolidinones. |
| AID285385 | Area under population analysis profile for methicillin-resistant Staphylococcus aureus using in vitro PK/PD model relative to growth control with 120 mg/24 hrs continuous infusion regimen after 72 hrs | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Pharmacokinetic/pharmacodynamic factors influencing emergence of resistance to linezolid in an in vitro model. |
| AID285010 | Antimicrobial activity against Enterococcus hirae at 0.5 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID41262 | In vitro antibacterial activity against Bacteroides fragilis strain ATCC 25285 | 1996 | Journal of medicinal chemistry, Feb-02, Volume: 39, Issue:3 | Synthesis and antibacterial activity of U-100592 and U-100766, two oxazolidinone antibacterial agents for the potential treatment of multidrug-resistant gram-positive bacterial infections. |
| AID1197121 | Antibacterial activity against Staphylococcus epidermidis ATCC 35547 after 16 to 20 hrs by broth microdilution method | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3 | Structure-activity relationship for the oxadiazole class of antibiotics. |
| AID349318 | Antibacterial activity against Escherichia coli ATCC 25922 after 18 hrs by agar dilution method | 2008 | European journal of medicinal chemistry, May, Volume: 43, Issue:5 | Synthesis and structure-antibacterial activity of triazolyl oxazolidinones containing long chain acyl moiety. |
| AID373998 | Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus 555 Hershey after 14 passages with CG400549 measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID255571 | In vitro minimum inhibitory concentration against Enterococcus faecium ATCC 29212 after incubation in air at 35 degree C for 24 hr using agar dilution method | 2005 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 15, Issue:19 | Synthesis and SAR of novel oxazolidinones: discovery of ranbezolid. |
| AID558479 | Antimicrobial activity against heterogeneous vancomycin-intermediate Staphylococcus aureus 168 measured on day 10 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID582984 | Antimicrobial activity against glycopeptide-resistant Enterococcus faecalis isolate HS0649 harboring MLST sequence type ST17 and pulsotype B expressing vanA gene cluster isolated from exudate of patient by Etest | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | vanM, a new glycopeptide resistance gene cluster found in Enterococcus faecium. |
| AID562621 | Antimicrobial activity against vancomycin-resistant Staphylococcus aureus assessed as susceptible isolates by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | In vitro activities of three new dihydrofolate reductase inhibitors against clinical isolates of gram-positive bacteria. |
| AID1414198 | Selectivity ratio of MBC for Staphylococcus aureus ATCC 25923 to MIC for Staphylococcus aureus ATCC 25923 | 2018 | European journal of medicinal chemistry, Nov-05, Volume: 159 | Design, synthesis and structure-based optimization of novel isoxazole-containing benzamide derivatives as FtsZ modulators. |
| AID633448 | Bacteriostatic activity against Staphylococcus aureus ATCC 01001 infected in thigh of CD1 mouse assessed as prevention of colony formation at 80 mg/kg, po administered 2 hrs post infection measured after 24 hrs | 2011 | Journal of medicinal chemistry, Dec-08, Volume: 54, Issue:23 | Antibacterial optimization of 4-aminothiazolyl analogues of the natural product GE2270 A: identification of the cycloalkylcarboxylic acids. |
| AID511430 | Antimicrobial activity against Clostridium perfringens LFM1 assessed as susceptibility breakpoint by DANMAP method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Resistance to linezolid in a porcine Clostridium perfringens strain carrying a mutation in the rplD gene encoding the ribosomal protein L4. |
| AID475003 | Antibacterial activity against vancomycin-resistant Enterococcus faecium LCB0008 by two fold serial dilution method | 2010 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 20, Issue:7 | Synthesis, crystal and antibacterial studies of diversely functionalized tetrahydropyridin-4-ol. |
| AID576672 | Bactericidal activity against 14 hrs peripheral compartment culture samples of Enterococcus faecalis Ef1497 in two-compartment pharmacokinetic/pharmacodynamic model assessed as effect on bacterial count at 600 mg, bid administered as 0.5 hr infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID499110 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus Smith OC 4172 infected immunocompromized SKH1 mouse assessed as lesion volume at 1.6 mg/kg/day, sc measured after 48 hrs postinfection (Rvb = 1181 mm3) | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vivo activity of ceftobiprole in murine skin infections due to Staphylococcus aureus and Pseudomonas aeruginosa. |
| AID535258 | Antimicrobial activity against vancomycin resistant Staphylococcus aureus VRS-6 expressing SCCmec type 2 element by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | In vitro activity of ceftaroline against community-associated methicillin-resistant, vancomycin-intermediate, vancomycin-resistant, and daptomycin-nonsusceptible Staphylococcus aureus isolates. |
| AID563323 | Antibacterial activity against vancomycin-susceptible Enterococcus faecalis EF 12704 assessed as log reduction in bacterial count at 12 mg/l after 24 hrs by time kill assay | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | In vivo activity of a novel anti-methicillin-resistant Staphylococcus aureus cephalosporin, ceftaroline, against vancomycin-susceptible and -resistant Enterococcus faecalis strains in a rabbit endocarditis model: a comparative study with linezolid and van |
| AID1861524 | Antibacterial activity against Linezolid-resistant Staphylococcus aureus Sta-5060 incubated for 18 hrs by CLSI protocol based two-fold serial agar dilution method | 2022 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 71 | WCK 4034: A promising oxazolidinone for treating gram positive infections. |
| AID585164 | Antibacterial activity against Mycobacterium smegmatis harboring 23S rRNA G2576U mutant after 24 generation times | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Mutations in 23S rRNA at the peptidyl transferase center and their relationship to linezolid binding and cross-resistance. |
| AID565487 | Bactericidal activity against methicillin-susceptible Staphylococcus aureus after 24 hrs by M26-A method in presence of 50% human plasma | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro bactericidal activity of iclaprim in human plasma. |
| AID285018 | Antimicrobial activity against Enterococcus raffinosus at 2 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID458452 | Antimicrobial activity against wild type Staphylococcus aureus SG 511 at 2 mM after overnight incubation by agar diffusion method | 2010 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 20, Issue:3 | Syntheses and antibacterial activity studies of new oxazolidinones from nitroso Diels-Alder chemistry. |
| AID542689 | fT>MIC in Bacillus anthracis infected in vitro hollow fiber PK/PD model at simulated dose of 200 mg administered every 24 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID753131 | Antitubercular activity against rifampicin-resistant Mycobacterium tuberculosis assessed as growth inhibition after 2 to 3 weeks by broth microdilution method | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | Anti-tubercular agents. Part 7: a new class of diarylpyrrole-oxazolidinone conjugates as antimycobacterial agents. |
| AID1770353 | Antibacterial activity against Vancomycin-resistant Enterococcus faecalis ATCC 51299 assessed as inhibition of bacterial growth measured after 20 hrs by two-fold microdilution assay | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Modification of 5-methylphenanthridium from benzothiazoles to indoles as potent FtsZ inhibitors: Broadening the antibacterial spectrum toward vancomycin-resistant enterococci. |
| AID560813 | AUC (0 to 24 hrs) in human adults with pulmonary tuberculosis at 600 mg administered twice daily for 7 days | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Population pharmacokinetics of linezolid in adults with pulmonary tuberculosis. |
| AID569342 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus by agar dilution method | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 | Design, synthesis and antibacterial activity of 3-methylenepyrrolidine formyl hydroxyamino derivatives as novel peptide deformylase inhibitors. |
| AID1689207 | Antibacterial activity against Escherichia coli BW25113 assessed as reduction in bacterial growth by CLSI based broth microdilution method | 2020 | European journal of medicinal chemistry, Mar-01, Volume: 189 | Oxadiazolylthiazoles as novel and selective antifungal agents. |
| AID1873909 | Antibacterial activity against Klebsiella pneumoniae ATCC 13883 incubated for 16 to 20 hrs by broth microdilution method | 2022 | European journal of medicinal chemistry, Aug-05, Volume: 238 | Design, synthesis and activity against drug-resistant bacteria evaluation of C-20, C-23 modified 5-O-mycaminosyltylonolide derivatives. |
| AID532790 | Antibacterial activity against vancomycin-intermediate Staphylococcus aureus 28160 after 24 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Improved antimicrobial activity of linezolid against vancomycin-intermediate Staphylococcus aureus. |
| AID759693 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 700699 assessed as growth inhibition after 18 to 24 hrs by broth microdilution method | 2013 | European journal of medicinal chemistry, Jul, Volume: 65 | New linezolid-like 1,2,4-oxadiazoles active against Gram-positive multiresistant pathogens. |
| AID311475 | Antimicrobial activity against methicillin-sensitive Staphylococcus aureus ATCC 29213 after 14 to 16 hrs by serial micro-broth dilution method | 2007 | Journal of natural products, Sep, Volume: 70, Issue:9 | Lipoxazolidinones A, B, and C: antibacterial 4-oxazolidinones from a marine actinomycete isolated from a Guam marine sediment. |
| AID499114 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus OC 8525 infected immunocompromized SKH1 mouse assessed as lesion volume at 1.6 mg/kg/day, sc measured after 48 hrs postinfection (Rvb = 1535 mm3) | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vivo activity of ceftobiprole in murine skin infections due to Staphylococcus aureus and Pseudomonas aeruginosa. |
| AID726195 | Antibacterial activity against Streptococcus agalactiae ATCC 2901 by agar dilution method | 2013 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 23, Issue:5 | Synthesis and antibacterial activities of new piperidine substituted (5R)-[1,2,3]triazolylmethyl and (5R)-[(4-F-[1,2,3]triazolyl)methyl] oxazolidinones. |
| AID285104 | Antimicrobial activity against viridans group Streptococcus mitis at 1 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID244828 | Minimum inhibitory concentration against Enterococcus faecalis ATCC 29212 | 2004 | Bioorganic & medicinal chemistry letters, Aug-02, Volume: 14, Issue:15 | Synthesis and antibacterial activity of arylpiperazinyl oxazolidinones with diversification of the N-substituents. |
| AID308490 | Antibacterial activity against Moraxella catarrhalis BC-3531 | 2007 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 17, Issue:16 | Synthesis and SAR of novel conformationally restricted oxazolidinones possessing gram-positive and fastidious gram-negative antibacterial activity. Part 2: Amino substitutions on heterocyclic D-ring system. |
| AID558474 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus 547 measured on day 5 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID581671 | Antibacterial activity against normal phenotype Staphylococcus aureus in cation-adjusted MH 2 broth at pH 5.5 after 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Intracellular activity of antibiotics in a model of human THP-1 macrophages infected by a Staphylococcus aureus small-colony variant strain isolated from a cystic fibrosis patient: pharmacodynamic evaluation and comparison with isogenic normal-phenotype a |
| AID1519042 | Antibacterial activity against clinical isolates of linezolid-resistant Enterococcus faecalis assessed as complete reduction in bacterial cell growth by CLSI protocol based broth liquid microdilution method | 2020 | European journal of medicinal chemistry, Jan-01, Volume: 185 | Optimization of biaryloxazolidinone as promising antibacterial agents against antibiotic-susceptible and antibiotic-resistant gram-positive bacteria. |
| AID348861 | Antibacterial activity against vancomycin-resistant Enterococcus 2 after 18 to 20 hrs by agar dilution method | 2008 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 18, Issue:21 | Synthesis and antibacterial activities of novel oxazolidinones having cyclic sulfonamide moieties. |
| AID522918 | Antibacterial activity against community-acquired methicillin-resistant panton-valentine leukocidin-positive Staphylococcus aureus isolate 1468 after 24 hrs by modified broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Antistaphylococcal activity of ACHN-490 tested alone and in combination with other agents by time-kill assay. |
| AID284948 | Antimicrobial activity against Bacillus spp. at 0.5 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID285068 | Antimicrobial activity against beta hemolytic Streptococci group G at 0.5 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID1594390 | Volume of distribution in human at 625 mg, iv | 2019 | Bioorganic & medicinal chemistry, 05-01, Volume: 27, Issue:9 | Second-generation aryl isonitrile compounds targeting multidrug-resistant Staphylococcus aureus. |
| AID1312951 | Bactericidal activity against vancomycin-resistant Staphylococcus aureus 10 clinical isolate after 20 hrs by broth microdilution method | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10 | Second-Generation Phenylthiazole Antibiotics with Enhanced Pharmacokinetic Properties. |
| AID374020 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus 543 after single-step resistance selection by agar dilution CLSI method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID734708 | Antibacterial activity against Staphylococcus MLS-16 MTCC 2940 after 24 hrs by agar dilution method | 2013 | European journal of medicinal chemistry, Apr, Volume: 62 | Synthesis, biological evaluation of new oxazolidino-sulfonamides as potential antimicrobial agents. |
| AID519084 | Antimicrobial activity against Escherichia coli KM75-84 harboring Gly153Arg mutation in rplC gene by agar dilution method in presence of 16 ug/ml polymyxin B nonapeptide | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Linezolid and tiamulin cross-resistance in Staphylococcus aureus mediated by point mutations in the peptidyl transferase center. |
| AID559782 | Antimicrobial activity against heterogeneous vancomycin-intermediate Staphylococcus aureus assessed as growth inhibition at 0.25 times MIC | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID285008 | Antimicrobial activity against Enterococcus hirae at 0.12 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID561236 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus assessed as resistant isolates by CLSI M100-S17 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | AFN-1252, a FabI inhibitor, demonstrates a Staphylococcus-specific spectrum of activity. |
| AID559370 | Antimicrobial activity against compound-resistant Coxiella burnetii isolate CP3 obtained from patient with acute Q fever infected in african green monkey Vero cells after 24 hrs by shell vial assay | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Bacteriostatic and bactericidal activities of tigecycline against Coxiella burnetii and comparison with those of six other antibiotics. |
| AID1574837 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus by broth liquid microdilution method | 2019 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 29, Issue:3 | Design and synthesis of biaryloxazolidinone derivatives containing a rhodanine or thiohydantoin moiety as novel antibacterial agents against Gram-positive bacteria. |
| AID1609263 | Bactericidal activity against vancomycin-resistant Enterococcus faecalis ATCC 51299 incubated for 18 to 20 hrs followed by replating on tryptic soy agar plate and further incubated for 18 to 24 hrs by CLSI-based broth microdilution assay | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Phenylthiazoles with nitrogenous side chain: An approach to overcome molecular obesity. |
| AID283158 | Antimicrobial susceptibility of Staphylococcus lugdunensis IDRL2492 biofilms after 24 hrs assessed as bacterial regrowth | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | In vitro effects of antimicrobial agents on planktonic and biofilm forms of Staphylococcus lugdunensis clinical isolates. |
| AID542710 | fT>MIC in Bacillus anthracis infected in vitro hollow fiber PK/PD model at simulated dose of 500 mg /day administered once every 24 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID562164 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus 547 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID574079 | Ratio of fAUC (24 hrs) for Methicillin-susceptible Staphylococcus aureus ATCC 13709 infected sc dosed mouse to MIC for Methicillin-susceptible Staphylococcus aureus ATCC 1370 | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | In vivo activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. |
| AID574081 | Ratio of fAUC (24 hrs) for community-associated methicillin-resistant Staphylococcus aureus OC8525 infected po dosed mouse to MIC for community-associated methicillin-resistant Staphylococcus aureus OC8525 | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | In vivo activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. |
| AID577120 | Cmax in two-compartment pharmacokinetic/pharmacodynamic model at 800 mg, bid administered as 0.5 hr infusion over 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID1059062 | Antibacterial activity against methicillin-resistant Staphylococcus aureus clinical isolate OM481 by liquid microdilution method | 2013 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 23, Issue:24 | Structure-anti-MRSA activity relationship of macrocyclic bis(bibenzyl) derivatives. |
| AID1609259 | Bactericidal activity against methicillin-resistant Streptococcus pneumoniae ATCC 700677 incubated for 18 to 20 hrs followed by replating on tryptic soy agar plate and further incubated for 18 to 24 hrs by CLSI-based broth microdilution assay | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Phenylthiazoles with nitrogenous side chain: An approach to overcome molecular obesity. |
| AID574070 | Tmax in CF-1 mouse serum at 10 mg/kg, sc | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | In vivo activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. |
| AID125078 | In vitro antibacterial activity against Moraxella catarrhalis 30607 (b-lactamase+). | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | The effect of remote chirality on the antibacterial activity of indolinyl, tetrahydroquinolyl and dihydrobenzoxazinyl oxazolidinones. |
| AID1853478 | Bactericidal activity against persister methicillin-resistant Staphylococcus aureus ATCC 33592 assessed as reduction in colony forming unit at 1 x MIC incubated for 18 to 24 hrs by Time-kill analysis | 2021 | RSC medicinal chemistry, Nov-17, Volume: 12, Issue:11 | SF |
| AID1493813 | Antibacterial activity against Pseudomonas aeruginosa ATCC 15442 after 20 hrs by broth microdilution method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Biphenylthiazole antibiotics with an oxadiazole linker: An approach to improve physicochemical properties and oral bioavailability. |
| AID567569 | Antimicrobial activity against Staphylococcus aureus RN4220 | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | First report of the multidrug resistance gene cfr and the phenicol resistance gene fexA in a Bacillus strain from swine feces. |
| AID1197130 | Antibacterial activity against vancomycin-susceptible Enterococcus faecium 119-39A clinical isolate after 16 to 20 hrs by broth microdilution method | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3 | Structure-activity relationship for the oxadiazole class of antibiotics. |
| AID555502 | Antibacterial activity against methicillin-susceptible coagulase-negative Staphylococcus epidermidis 057 after 50 passages by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Antistaphylococcal activity of dihydrophthalazine antifolates, a family of novel antibacterial drugs. |
| AID604291 | Antibacterial activity against Enterococcus faecium ATCC 19434 after 16 to 24 hrs by twofold serial dilution method | 2011 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 21, Issue:14 | 7-Alkyl-N(2)-substituted-3-deazaguanines. Synthesis, DNA polymerase III inhibition and antibacterial activity. |
| AID575148 | Antimicrobial activity against vancomycin-resistant Staphylococcus aureus VRS2 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Inhibition of antibiotic-resistant Staphylococcus aureus by the broad-spectrum dihydrofolate reductase inhibitor RAB1. |
| AID1680051 | Antibacterial activity against carbapenem-resistant Klebsiella pneumoniae clinical isolate 5 assessed as reduction in bacterial growth incubated for 16 to 20 hrs by CLSI-based broth microdilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Synthesis and antibacterial bioactivities of cationic deacetyl linezolid amphiphiles. |
| AID533016 | Antibacterial activity against vancomycin-susceptible Staphylococcus aureus N315-LR5-P1 assessed as inhibition of bacterial growth in brain heart infusion broth medium | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Improved antimicrobial activity of linezolid against vancomycin-intermediate Staphylococcus aureus. |
| AID717208 | Antimicrobial activity against methicillin-sensitive Staphylococcus aureus CCARM 0027 incubated for 24 hrs by microtiter broth dilution method | 2012 | Journal of natural products, Dec-28, Volume: 75, Issue:12 | Antibacterial butenolides from the Korean tunicate Pseudodistoma antinboja. |
| AID1269332 | Half life in mouse liver microsomes | 2016 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 26, Issue:2 | Synthesis and evaluation of pretomanid (PA-824) oxazolidinone hybrids. |
| AID573862 | Antibacterial activity against penicillin-susceptible Streptococcus pneumoniae ATCC 6301 after 16 to 20 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | In vivo activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. |
| AID523811 | Antimicrobial activity against linezolid-susceptible coagulase-negative Staphylococcus assessed as inhibition of microbial growth at 1 ug/ml by CLSI method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative activities of TR-700 (torezolid) against staphylococcal blood isolates collected in Spain. |
| AID584971 | Antibacterial activity against Mycobacterium smegmatis SZ558 after 24 generation times | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Mutations in 23S rRNA at the peptidyl transferase center and their relationship to linezolid binding and cross-resistance. |
| AID577125 | Residual concentration at the end of the administration interval in two-compartment pharmacokinetic/pharmacodynamic model at 600 mg, bid administered as 0.5 hr infusion over 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID209464 | In vitro antibacterial activity against Streptococcus pyogenes C6003 (S.p.2). | 1999 | Bioorganic & medicinal chemistry letters, Sep-20, Volume: 9, Issue:18 | Synthesis and in vitro activity of new oxazolidinone antibacterial agents having substituted isoxazoles. |
| AID1832940 | Antibacterial activity against Staphylococcus aureus ATCC 9144 assessed as reduction in bacterial growth incubated for 20 hrs by microplate reader method | 2021 | Bioorganic & medicinal chemistry, 11-01, Volume: 49 | Synthesis, microbiological evaluation and structure activity relationship analysis of linezolid analogues with different C5-acylamino substituents. |
| AID560578 | Bactericidal activity against vancomycin-resistant Enterococcus faecium 1119175 expressing vanB gene assessed as change in bacterial count at 16 ug/ml by time-kill assay | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Impact of human serum albumin on oritavancin in vitro activity against enterococci. |
| AID1501356 | Antibacterial activity against Staphylococcus aureus RN4220 NRS107 after 20 hrs by broth microdilution assay | 2017 | European journal of medicinal chemistry, Oct-20, Volume: 139 | Arylthiazole antibiotics targeting intracellular methicillin-resistant Staphylococcus aureus (MRSA) that interfere with bacterial cell wall synthesis. |
| AID1692903 | Antibacterial activity against linezolid-resistant Enterococcus faecalis | 2021 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 32 | Design, synthesis and antibacterial evaluation of novel oxazolidinone derivatives nitrogen-containing fused heterocyclic moiety. |
| AID387454 | Antibacterial activity against linezolid-resistant Enterococcus faecalis DRCC 632 | 2008 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 18, Issue:18 | Novel and potent oxazolidinone antibacterials featuring 3-indolylglyoxamide substituents. |
| AID1861523 | Antibacterial activity against Linezolid-resistant Staphylococcus aureus Sta-5059 incubated for 18 hrs by CLSI protocol based two-fold serial agar dilution method | 2022 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 71 | WCK 4034: A promising oxazolidinone for treating gram positive infections. |
| AID560373 | Antimicrobial activity against vancomycin-resistant Enterococcus faecium 1059060 by broth dilution method in presence of 4% HSA | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Impact of human serum albumin on oritavancin in vitro activity against enterococci. |
| AID1390462 | Antibacterial activity against Staphylococcus aureus ATCC 29213 | 2018 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 28, Issue:7 | Design, synthesis and biological evaluation of spiropyrimidinetriones oxazolidinone derivatives as antibacterial agents. |
| AID577118 | Cmax in two-compartment pharmacokinetic/pharmacodynamic model at 200 mg, bid administered as 0.5 hr infusion over 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID528840 | Antimicrobial activity against penicillin-resistant Streptococcus pneumoniae isolated from ICU patient respiratory tract assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID1594388 | Clearance in human at 625 mg, iv | 2019 | Bioorganic & medicinal chemistry, 05-01, Volume: 27, Issue:9 | Second-generation aryl isonitrile compounds targeting multidrug-resistant Staphylococcus aureus. |
| AID523800 | Antimicrobial activity against linezolid-susceptible Staphylococcus aureus assessed as inhibition of microbial growth at 0.5 ug/ml by CLSI method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative activities of TR-700 (torezolid) against staphylococcal blood isolates collected in Spain. |
| AID1311358 | Antibacterial activity against Acinetobacter baumannii 6M-1b measured after 18 hrs by broth microdilution assay | 2016 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15 | An evolved oxazolidinone with selective potency against Mycobacterium tuberculosis and gram positive bacteria. |
| AID375938 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 33591 after 24 hrs by broth microdilution method | 2006 | Journal of natural products, Apr, Volume: 69, Issue:4 | Antibacterial, partially acetylated oligorhamnosides from Cleistopholis patens. |
| AID410220 | Antibacterial activity against Escherichia coli LCB0011 by broth micro dilution method | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24 | A facile synthesis, antibacterial, and antitubercular studies of some piperidin-4-one and tetrahydropyridine derivatives. |
| AID524720 | Antibacterial activity against linezolid-resistant Enterococcus faecalis ATCC 29212 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro antibacterial activity of CE-156811, a novel analog derived from hygromycin A. |
| AID1594368 | Antibacterial activity against Enterobacter cloacae BAA1134 after 18 to 24 hrs by broth microdilution assay | 2019 | Bioorganic & medicinal chemistry, 05-01, Volume: 27, Issue:9 | Second-generation aryl isonitrile compounds targeting multidrug-resistant Staphylococcus aureus. |
| AID1271213 | Plasma protein binding in human | 2015 | ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11 | Design, Synthesis, and Identification of Silicon Incorporated Oxazolidinone Antibiotics with Improved Brain Exposure. |
| AID581012 | Antimicrobial activity against Staphylococcus aureus ATCC 25923 by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Mode of action of Ranbezolid against staphylococci and structural modeling studies of its interaction with ribosomes. |
| AID1168004 | Antibacterial activity against vancomycin-resistant Enterococcus faecium clinical isolate 23/240 after overnight incubation by two-fold serial dilution method | 2014 | Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21 | Synthesis and biological evaluation of novel peptide BF2 as an antibacterial agent against clinical isolates of vancomycin-resistant enterococci. |
| AID210056 | Compound was evaluated for minimum inhibitory concentration against Streptococcus pneumoniae 9798 strain | 2002 | Bioorganic & medicinal chemistry letters, Mar-25, Volume: 12, Issue:6 | Synthesis and antibacterial activity of linezolid analogues. |
| AID498896 | Tmax in immunocompetent SKH1 mouse plasma at 50 mg/kg, po | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vivo activity of ceftobiprole in murine skin infections due to Staphylococcus aureus and Pseudomonas aeruginosa. |
| AID132799 | compound was tested against Staphylococcus aureus UC9213 the vancomycin administered (sc) in mouse positive control expressed as ED50 values. | 1998 | Journal of medicinal chemistry, Sep-10, Volume: 41, Issue:19 | Piperazinyl oxazolidinone antibacterial agents containing a pyridine, diazene, or triazene heteroaromatic ring. |
| AID1451765 | Antibacterial activity against Staphylococcus aureus Mu50 infected in BALB/c mouse assessed as reduction of bacterial burden in heart at 0.4 mg, ip bid for 4.5 days treated 24 hrs prior to bacterial infection measured 108 hrs post infection relative to co | 2017 | Journal of medicinal chemistry, 10-12, Volume: 60, Issue:19 | Novel Inhibitors of Staphyloxanthin Virulence Factor in Comparison with Linezolid and Vancomycin versus Methicillin-Resistant, Linezolid-Resistant, and Vancomycin-Intermediate Staphylococcus aureus Infections in Vivo. |
| AID405629 | Toxicity in rat liver mitochondria assessed as inhibition of mitochondrial protein synthesis | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Comparative study of the effects of pyridoxine, rifampin, and renal function on hematological adverse events induced by linezolid. |
| AID559770 | Antimicrobial activity against SCCmec type II vancomycin-intermediate Staphylococcus aureus isolate 4sy32 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID1181167 | Antimicrobial activity against first mutant generation Mycobacterium tuberculosis 1024_1 assessed as fold shift in MIC relative to parent strain | 2014 | Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15 | Diarylthiazole: an antimycobacterial scaffold potentially targeting PrrB-PrrA two-component system. |
| AID560361 | Cmin in healthy human male at 600 mg, po every 12 hrs by LC/MS/MS analysis | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Impact of human serum albumin on oritavancin in vitro activity against enterococci. |
| AID1596567 | Bactericidal activity against methicillin resistant Staphylococcus epidermidis NRS101 assessed as reduction in bacterial cell growth incubated for 18 to 20 hrs followed by re-plating on tryptic soy agar plates at 37 degC for 18 hrs by broth microdilution | 2019 | European journal of medicinal chemistry, Aug-01, Volume: 175 | Lipophilic efficient phenylthiazoles with potent undecaprenyl pyrophosphatase inhibitory activity. |
| AID542676 | fCmax in Bacillus anthracis infected in vitro hollow fiber PK/PD model at simulated dose of 5000 mg administered every 24 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID574066 | fCmax in CF-1 mouse at 2 mg/kg, iv | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | In vivo activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. |
| AID541059 | Ratio of Cmax to MIC for methicillin-resistant Staphylococcus aureus ATCC 43300 in Albino guiena pig model of foreign-body infection at 25 mg/kg, ip | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Linezolid alone or combined with rifampin against methicillin-resistant Staphylococcus aureus in experimental foreign-body infection. |
| AID573129 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID734691 | Antibacterial activity against Bacillus subtilis MTCC 121 at 20 ug/ml after 24 hrs by disk diffusion method | 2013 | European journal of medicinal chemistry, Apr, Volume: 62 | Synthesis, biological evaluation of new oxazolidino-sulfonamides as potential antimicrobial agents. |
| AID522820 | Antibacterial activity against vancomycin-susceptible Staphylococcus aureus after 24 hrs by modified broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Antistaphylococcal activity of ACHN-490 tested alone and in combination with other agents by time-kill assay. |
| AID558725 | Antimicrobial activity against vancomycin-resistant Staphylococcus aureus 510 measured on day 45 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID574085 | Ratio of fAUC (24 hrs) for penicillin-susceptible Streptococcus pneumoniae ATCC 6301 infected sc dosed mouse to MIC for penicillin-susceptible Streptococcus pneumoniae ATCC 6301 | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | In vivo activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. |
| AID245240 | In vitro minimum inhibitory concentration against Staphylococcus aureus (ATCC 25923 and 29213) | 2005 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 15, Issue:12 | Synthesis and antibacterial activity of novel (un)substituted benzotriazolyl oxazolidinone derivatives. |
| AID562190 | Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus 555 measured after 10 antibiotic-free subculturing by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID542387 | Antimicrobial activity against Staphylococcus aureus RN4220 | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Methicillin-resistant and -susceptible Staphylococcus aureus strains of clonal lineages ST398 and ST9 from swine carry the multidrug resistance gene cfr. |
| AID1197115 | Antibacterial activity against mecA-positive, methicillin/oxacillin/tetracycline-resistant and vancomycin/linezolid susceptible Staphylococcus aureus ATCC 27660 after 16 to 20 hrs by broth microdilution method | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3 | Structure-activity relationship for the oxadiazole class of antibiotics. |
| AID1649293 | Antibacterial activity against Streptococcus pneumoniae tupelo (VTSP) assessed as inhibition of bacterial growth incubated for 20 hrs by microdilution broth method | |||
| AID285545 | AUC (0-24 hrs) in mouse at 20 mg/kg, sc | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | In vitro and in vivo antibacterial activities of heteroaryl isothiazolones against resistant gram-positive pathogens. |
| AID759690 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus M923 assessed as growth inhibition after 18 to 24 hrs by broth microdilution method | 2013 | European journal of medicinal chemistry, Jul, Volume: 65 | New linezolid-like 1,2,4-oxadiazoles active against Gram-positive multiresistant pathogens. |
| AID517665 | Antimicrobial activity against Staphylococcus aureus FDA209P by standard serial-dilution technique | 2010 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 20, Issue:20 | Bottromycin derivatives: efficient chemical modifications of the ester moiety and evaluation of anti-MRSA and anti-VRE activities. |
| AID1474166 | Liver toxicity in human assessed as induction of drug-induced liver injury by measuring severity class index | 2016 | Drug discovery today, Apr, Volume: 21, Issue:4 | DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. |
| AID67397 | In vitro antibacterial activity against Enterococcus faecalis C6291 (E. f. 1) | 2003 | Bioorganic & medicinal chemistry letters, Jul-07, Volume: 13, Issue:13 | Synthesis and in vitro activity of new methylenepiperidinyl and methylenepyrrolidinyl oxazolidinone antibacterial agents. |
| AID1744563 | Antibacterial activity against methicillin sensitive Staphylococcus aureus assessed as inhibition of bacterial growth measured after 16 hrs by agar plate dilution method | 2021 | ACS medicinal chemistry letters, Mar-11, Volume: 12, Issue:3 | Semisynthesis and Biological Evaluation of Platencin Thioether Derivatives: Dual FabF and FabH Inhibitors against MRSA. |
| AID268861 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 33591 | 2006 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 16, Issue:16 | Synthesis of novel tricyclic oxazolidinones by a tandem SN2 and SNAr reaction: SAR studies on conformationally constrained analogues of Linezolid. |
| AID523816 | Antimicrobial activity against oxacillin-susceptible coagulase-negative Staphylococcus aureus assessed as inhibition of microbial growth at 1 ug/ml by CLSI method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative activities of TR-700 (torezolid) against staphylococcal blood isolates collected in Spain. |
| AID533981 | Antimicrobial activity against linezolid-resistant Staphylococcus aureus SA238L infected in THP1 cells after 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Cellular pharmacodynamics of the novel biaryloxazolidinone radezolid: studies with infected phagocytic and nonphagocytic cells, using Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Legionella pneumophila. |
| AID542386 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus ST9 expressing cfr, fexA and erm(C) genes | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Methicillin-resistant and -susceptible Staphylococcus aureus strains of clonal lineages ST398 and ST9 from swine carry the multidrug resistance gene cfr. |
| AID1574841 | Antibacterial activity against clinical isolates of linezolid-resistant Enterococcus faecalis by broth liquid microdilution method | 2019 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 29, Issue:3 | Design and synthesis of biaryloxazolidinone derivatives containing a rhodanine or thiohydantoin moiety as novel antibacterial agents against Gram-positive bacteria. |
| AID1770362 | Ratio of MBC to MIC against methicilline-resistant Staphylococcus aureus ATCC43300 | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Modification of 5-methylphenanthridium from benzothiazoles to indoles as potent FtsZ inhibitors: Broadening the antibacterial spectrum toward vancomycin-resistant enterococci. |
| AID326510 | Tmax in Enterococcus faecalis infected Wistar rat at 600 mg, po two consecutive administration every 12 hrs | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Single-dose oral amoxicillin or linezolid for prophylaxis of experimental endocarditis due to vancomycin-susceptible and vancomycin-resistant Enterococcus faecalis. |
| AID284997 | Antimicrobial activity against Enterococcus durans at 0.5 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID558731 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus 525 measured on day 50 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID604293 | Antibacterial activity against Escherichia coli J-53 after 16 to 24 hrs by twofold serial dilution method | 2011 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 21, Issue:14 | 7-Alkyl-N(2)-substituted-3-deazaguanines. Synthesis, DNA polymerase III inhibition and antibacterial activity. |
| AID1329446 | Antibacterial activity against linezolid-resistant Mycobacterium tuberculosis H37Rv in hollow-fiber infection model assessed as reduction in bacterial burden at 858 mg, po at 24 hrs dose regimen measured after 3 weeks | 2016 | Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24 | From lead optimization to NDA approval for a new antimicrobial: Use of pre-clinical effect models and pharmacokinetic/pharmacodynamic mathematical modeling. |
| AID293840 | Antibacterial activity against vancomycin-resistant Enterococcus faecium VRA | 2007 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6 | A new class of anti-MRSA and anti-VRE agents: preparation and antibacterial activities of indole-containing compounds. |
| AID1474225 | Antibacterial activity against vancomycin-resistant Enterococcus faecium ATCC HM-968 assessed as ratio of MIC after and before 3 serial passages measured after 18 hrs by broth microdillution method | 2017 | Journal of medicinal chemistry, 03-23, Volume: 60, Issue:6 | Phenylthiazole Antibacterial Agents Targeting Cell Wall Synthesis Exhibit Potent Activity in Vitro and in Vivo against Vancomycin-Resistant Enterococci. |
| AID1611119 | Antibacterial activity against methicillin-resistant Staphylococcus aureus CLSI-based double dilution method | 2019 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 29, Issue:23 | Design and synthesis of biaryloxazolidinone derivatives containing amide or acrylamide moiety as novel antibacterial agents against Gram-positive bacteria. |
| AID729176 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 33591 infected in po dosed systemic infection mouse model administered 1 hr post infection measured after 24 hrs | 2013 | Journal of medicinal chemistry, Mar-28, Volume: 56, Issue:6 | Solubility-driven optimization of (pyridin-3-yl) benzoxazinyl-oxazolidinones leading to a promising antibacterial agent. |
| AID1887588 | Antibacterial activity against Staphylococcus aureus ATCC 29213 at 1 time MIC after 24 hrs by time kill assay | 2022 | Journal of natural products, 10-28, Volume: 85, Issue:10 | Developing the Natural Prenylflavone Artocarpin from |
| AID562593 | Antimicrobial activity against Enterococcus faecalis expressing VanA gene clinical isolates assessed as resistant isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID326515 | Cmin in Enterococcus faecalis infected Wistar rat at 600 mg, po dosed consecutive administration every 12 hrs | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Single-dose oral amoxicillin or linezolid for prophylaxis of experimental endocarditis due to vancomycin-susceptible and vancomycin-resistant Enterococcus faecalis. |
| AID207794 | Compound was evaluated for minimum inhibitory concentration against Staphylococcus aureus 966 strain | 2002 | Bioorganic & medicinal chemistry letters, Mar-25, Volume: 12, Issue:6 | Synthesis and antibacterial activity of linezolid analogues. |
| AID745402 | Antibacterial activity against Moraxella catarrhalis SR26840 clinical isolate assessed as growth inhibition by CLSI broth microdilution method | 2013 | European journal of medicinal chemistry, May, Volume: 63 | Antibacterial oxazolidinone analogues having a N-hydroxyacetyl-substituted seven-membered [1,2,5]triazepane or [1,2,5]oxadiazepane C-ring unit. |
| AID287263 | Antimicrobial activity against vancomycin-sensitive Enterococcus by agar dilution method | 2007 | European journal of medicinal chemistry, Feb, Volume: 42, Issue:2 | Structure-antibacterial activity of arylcarbonyl- and arylsulfonyl-piperazine 5-triazolylmethyl oxazolidinones. |
| AID1197117 | Antibacterial activity against mecA-positive, ciprofloxacin/gentamicin/oxacillin/penicillin/linezolid-resistant Staphylococcus aureus NRS119 after 16 to 20 hrs by broth microdilution method | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3 | Structure-activity relationship for the oxadiazole class of antibiotics. |
| AID368288 | Bactericidal activity against methicillin-resistant Staphylococcus aureus SA2 in rabbit endocarditis model assessed per gram of aortic vegetation at 58 mg/kg infused every 12 hrs for 4 days measured after 48 hrs | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vivo efficacy of ceftaroline (PPI-0903), a new broad-spectrum cephalosporin, compared with linezolid and vancomycin against methicillin-resistant and vancomycin-intermediate Staphylococcus aureus in a rabbit endocarditis model. |
| AID577122 | Tmax in two-compartment pharmacokinetic/pharmacodynamic model at 600 mg, bid administered as 0.5 hr infusion over 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID285027 | Antimicrobial activity against Micrococcus luteus at 0.25 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID1474194 | Antibacterial activity against Escherichia coli 1411 after 18 to 22 hrs in absence of colistin by broth microdilution method | 2017 | Journal of medicinal chemistry, 03-23, Volume: 60, Issue:6 | Phenylthiazole Antibacterial Agents Targeting Cell Wall Synthesis Exhibit Potent Activity in Vitro and in Vivo against Vancomycin-Resistant Enterococci. |
| AID1609268 | Antibacterial activity against vancomycin-resistant Enterococcus faecium ATCC 700221 after 18 to 20 hrs by CLSI-based broth microdilution assay | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Phenylthiazoles with nitrogenous side chain: An approach to overcome molecular obesity. |
| AID348862 | Antibacterial activity against vancomycin-resistant Enterococcus 3 after 18 to 20 hrs by agar dilution method | 2008 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 18, Issue:21 | Synthesis and antibacterial activities of novel oxazolidinones having cyclic sulfonamide moieties. |
| AID449617 | Antibacterial activity against methicillin-susceptible Staphylococcus epidermidis by agar dilution method | 2009 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 19, Issue:18 | Water-soluble phosphate prodrugs of pleuromutilin analogues with potent in vivo antibacterial activity against Gram-positive pathogens. |
| AID207026 | Antibacterial activity against methicillin susceptible Staphylococcus aureus (OC 4172) in presence of 50% mouse serum | 2001 | Bioorganic & medicinal chemistry letters, Jul-23, Volume: 11, Issue:14 | Novel piperidinyloxy oxazolidinone antimicrobial agents. |
| AID348601 | Antibacterial activity against Haemophilus influenzae after 18 to 20 hrs by agar dilution method | 2008 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 18, Issue:21 | Synthesis and antibacterial activities of novel oxazolidinones having cyclic sulfonamide moieties. |
| AID1395706 | Bactericidal activity against methicillin-resistant Staphylococcus aureus NRS123 USA400 incubated fo 18 hrs followed by re-plating on tryptic soy agar plates at 37 degC for 18 hrs by broth microdilution assay | 2018 | European journal of medicinal chemistry, May-10, Volume: 151 | Phenylthiazoles with tert-Butyl side chain: Metabolically stable with anti-biofilm activity. |
| AID532802 | Antibacterial activity against vancomycin-susceptible Staphylococcus aureus AMC11094 after 24 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Improved antimicrobial activity of linezolid against vancomycin-intermediate Staphylococcus aureus. |
| AID528716 | Antibacterial activity against methicillin resistant Staphylococcus epidermidis clinical isolate assessed as susceptibility level by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID533385 | Antimicrobial activity against Clostridium difficile by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activities of doripenem, a new broad-spectrum carbapenem, against recently collected clinical anaerobic isolates, with emphasis on the Bacteroides fragilis group. |
| AID1594384 | Tmax in human at 625 mg, po | 2019 | Bioorganic & medicinal chemistry, 05-01, Volume: 27, Issue:9 | Second-generation aryl isonitrile compounds targeting multidrug-resistant Staphylococcus aureus. |
| AID396032 | Antibacterial activity against drug-resistant AcrAB-TolC efflux pump deficient Enterobacter cloacae EcdeltaacrA isolate expressing pAP3 plasmid containing Enterobacter aerogenes acrR gene by Etest | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Cloning, nucleotide sequencing, and analysis of the AcrAB-TolC efflux pump of Enterobacter cloacae and determination of its involvement in antibiotic resistance in a clinical isolate. |
| AID509630 | Antimicrobial activity against Staphylococcus aureus RN4220 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Identification of a plasmid-borne resistance gene cluster comprising the resistance genes erm(T), dfrK, and tet(L) in a porcine methicillin-resistant Staphylococcus aureus ST398 strain. |
| AID558476 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus 543 measured on day 5 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID1076831 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus CMCC 26003 assessed as growth inhibition after 18 hrs by broth microdilution method | 2014 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 24, Issue:6 | Discovery of novel bis-oxazolidinone compounds as potential potent and selective antitubercular agents. |
| AID542681 | fAUC (24 hrs) in Bacillus anthracis infected in vitro hollow fiber PK/PD model at simulated dose of 200 mg administered every 24 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID583894 | Antibacterial activity against vancomycin-intermediate Staphylococcus aureus isolate 440 (A6298) by broth microdilution assay | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Comparative efficacies of human simulated exposures of telavancin and vancomycin against methicillin-resistant Staphylococcus aureus with a range of vancomycin MICs in a murine pneumonia model. |
| AID1311362 | Antibacterial activity against Klebsiella pneumoniae ATCC 35657 measured after 18 hrs by broth microdilution assay | 2016 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15 | An evolved oxazolidinone with selective potency against Mycobacterium tuberculosis and gram positive bacteria. |
| AID285111 | Antimicrobial activity against viridans group Streptococcus mutans at 2 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID326519 | T>MIC in Enterococcus faecalis infected Wistar rat at single administration of 600 mg, po | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Single-dose oral amoxicillin or linezolid for prophylaxis of experimental endocarditis due to vancomycin-susceptible and vancomycin-resistant Enterococcus faecalis. |
| AID295158 | Antibacterial activity against Enterococcus faecalis by microdilution broth method | 2007 | European journal of medicinal chemistry, Aug, Volume: 42, Issue:8 | Synthesis and antibacterial activity of oxazolidinones containing triazolyl group. |
| AID285548 | Plasma half life in mouse at 50 mg/kg, sc | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | In vitro and in vivo antibacterial activities of heteroaryl isothiazolones against resistant gram-positive pathogens. |
| AID304002 | AUC (0 to 24 hrs) in Sprague-Dawley rat plasma at 200 mg/kg/day, po after 14 days | 2007 | Journal of medicinal chemistry, Nov-29, Volume: 50, Issue:24 | Antibacterial oxazolidinones possessing a novel C-5 side chain. (5R)-trans-3-[3-Fluoro-4- (1-oxotetrahydrothiopyran-4-yl)phenyl]-2- oxooxazolidine-5-carboxylic acid amide (PF-00422602), a new lead compound. |
| AID1676980 | Antimicrobial activity against vancomycin-resistant Enterococcus faecium ATCC 51299 assessed as reduction in microbial growth after 48 hrs by CLSI based broth microdilution method | |||
| AID559553 | Antimicrobial activity against compound-resistant Coxiella burnetii isolate CP5 obtained from patient with acute Q fever infected in african green monkey Vero cells after 24 hrs by shell vial assay | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Bacteriostatic and bactericidal activities of tigecycline against Coxiella burnetii and comparison with those of six other antibiotics. |
| AID206442 | In vitro antibacterial activity against methicillin resistant Staphylococcus aureus UC 12673 (MRSA); range is 2-4 | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | The synthesis and antibacterial activity of 1,3,4-thiadiazole phenyl oxazolidinone analogues. |
| AID1180575 | Antimicrobial activity against Staphylococcus aureus ARC2381 by broth microdilution/CLSI method | 2014 | Journal of medicinal chemistry, Jul-24, Volume: 57, Issue:14 | Optimization of pyrrolamide topoisomerase II inhibitors toward identification of an antibacterial clinical candidate (AZD5099). |
| AID255577 | In vitro minimum inhibitory concentration against vancomycin-resistant Enterococcus faecium 6A after incubation in air at 35 degree C for 24 hr using agar dilution method | 2005 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 15, Issue:19 | Synthesis and SAR of novel oxazolidinones: discovery of ranbezolid. |
| AID1352005 | Antibacterial activity against vancomycin-intermediate methicillin-resistant Staphylococcus aureus Mu50 infected in BALB/c mouse assessed as decrease in bacterial survival in mouse liver at 0.4 mg, ip bid administered 4.5 days measured after 90 hrs | 2018 | European journal of medicinal chemistry, Feb-10, Volume: 145 | Discovery of novel piperonyl derivatives as diapophytoene desaturase inhibitors for the treatment of methicillin-, vancomycin- and linezolid-resistant Staphylococcus aureus infections. |
| AID542918 | Antimicrobial activity against Bacillus anthracis infected in in vitro hollow fiber PK/PD model assessed as cell killing at 800 mg administered as 2 divided doses every 12 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID245169 | Minimum inhibitory concentration against Enterococcus faecalis ATCC 29212; value ranges from 3-6 uM | 2004 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 14, Issue:22 | Aryl urea analogs with broad-spectrum antibacterial activity. |
| AID318359 | Antibacterial activity against Streptococcus pneumoniae | 2007 | Proceedings of the National Academy of Sciences of the United States of America, May-01, Volume: 104, Issue:18 | Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties. |
| AID534506 | Drug level in human THP1 cells at 50 mg/L after 2 hrs in presence of 50 uM proton inophore monesin relative to control | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Cellular pharmacokinetics of the novel biaryloxazolidinone radezolid in phagocytic cells: studies with macrophages and polymorphonuclear neutrophils. |
| AID549013 | Antimicrobial activity against Vancomycin-nonsusceptible Enterococcus faecium assessed as percent resistant isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Activities of dalbavancin against a worldwide collection of 81,673 gram-positive bacterial isolates. |
| AID1271205 | Solubility of compound at pH 4.5 by HPLC analysis | 2015 | ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11 | Design, Synthesis, and Identification of Silicon Incorporated Oxazolidinone Antibiotics with Improved Brain Exposure. |
| AID1304852 | Ratio of MIC for methicillin-resistant Staphylococcus aureus clinical isolate 2 in absence and presence of Fe2+ | 2016 | Journal of medicinal chemistry, 04-28, Volume: 59, Issue:8 | Structure-Activity Relationships of a Diverse Class of Halogenated Phenazines That Targets Persistent, Antibiotic-Tolerant Bacterial Biofilms and Mycobacterium tuberculosis. |
| AID576430 | Bactericidal activity against 2 hrs peripheral compartment culture samples of Staphylococcus aureus RN4220 in two-compartment pharmacokinetic/pharmacodynamic model assessed as effect on bacterial count at 600 mg, bid administered as 0.5 hr infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID291412 | Antibacterial activity against Enterococcus faecalis 03-4 after 18 to 24 hrs | 2007 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 17, Issue:16 | Synthesis and antibacterial activity of novel fluoroquinolones containing substituted piperidines. |
| AID532798 | Antibacterial activity against vancomycin-intermediate Staphylococcus aureus MI after 24 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Improved antimicrobial activity of linezolid against vancomycin-intermediate Staphylococcus aureus. |
| AID1852694 | Antibacterial activity against Escherichia coli SQ110 incubated for 24 hrs by twofold serial dilution method | |||
| AID373826 | Antimicrobial activity against panton-valentine leukocidin-negative community-acquired methicillin-resistant Staphylococcus aureus 481 after 37 passages with Linezolid measured after 10 antibiotic-free subculture by multi-step resistance selection techniq | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID30969 | Harmonic mean apparent terminal disposition half-life [t1/2beta (h)] in Male Sprague-Dawley Rat at dose 25 (mg/kg po) | 2003 | Journal of medicinal chemistry, Jan-16, Volume: 46, Issue:2 | Identification of phenylisoxazolines as novel and viable antibacterial agents active against Gram-positive pathogens. |
| AID561247 | Antibacterial activity against methicillin-resistant Staphylococcus epidermidis assessed as intermediate isolates by CLSI M100-S17 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | AFN-1252, a FabI inhibitor, demonstrates a Staphylococcus-specific spectrum of activity. |
| AID1596572 | Bactericidal activity against Methicillin resistant Streptococcus pneumoniae ATCC 700677 assessed as reduction in bacterial cell growth incubated for 18 to 20 hrs followed by re-plating on tryptic soy agar plates at 37 degC for 18 hrs by broth microdiluti | 2019 | European journal of medicinal chemistry, Aug-01, Volume: 175 | Lipophilic efficient phenylthiazoles with potent undecaprenyl pyrophosphatase inhibitory activity. |
| AID520232 | Antimicrobial activity against Streptococcus pneumoniae 02J1175 | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID541051 | Ratio of AUC (0 to 24 hrs) to MIC for methicillin-resistant Staphylococcus aureus ATCC 43300 in Albino guiena pig model of foreign-body infection at 75 mg/kg, ip | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Linezolid alone or combined with rifampin against methicillin-resistant Staphylococcus aureus in experimental foreign-body infection. |
| AID133296 | Minimum inhibitory concentration of the subcutaneously administered compound evaluated against Staphylococcus aureus GO3 strain in mice (SC) | 2000 | Bioorganic & medicinal chemistry letters, Aug-07, Volume: 10, Issue:15 | Improved antibacterial activities of coumarin antibiotics bearing 5',5'-dialkylnoviose: biological activity of RU79115. |
| AID475011 | Antibacterial activity against Moraxella catarrhalis LCB0016 by two fold serial dilution method | 2010 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 20, Issue:7 | Synthesis, crystal and antibacterial studies of diversely functionalized tetrahydropyridin-4-ol. |
| AID499166 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus OC 8525 infected in SKH1 mouse assessed as log change in bacterial colony forming unit per gram of skin tissue at 6.2 mg/kg/day, po (Rvb = 0.8 deltalog CFU) | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vivo activity of ceftobiprole in murine skin infections due to Staphylococcus aureus and Pseudomonas aeruginosa. |
| AID1778090 | Antitubercular activity against Mycobacterium tuberculosis H37Rv assessed as inhibition of bacterial growth incubated for 7 days by MABA | |||
| AID695444 | Antibacterial activity against fluoroquinolone resistant Staphylococcus aureus 3-FQR3M ATCC 700699 expressing GyrA Ser84Leu mutant and Glu409Lys mutant and GrlA Ser80Phe mutant | 2011 | Journal of medicinal chemistry, May-12, Volume: 54, Issue:9 | Selenophene-containing inhibitors of type IIA bacterial topoisomerases. |
| AID112681 | In vivo antibacterial activity against Enterococcus faecalis strain UC 12379 administered perorally in mice | 1996 | Journal of medicinal chemistry, Feb-02, Volume: 39, Issue:3 | Synthesis and antibacterial activity of U-100592 and U-100766, two oxazolidinone antibacterial agents for the potential treatment of multidrug-resistant gram-positive bacterial infections. |
| AID1861534 | Volume of distribution in Wistar rat at 15 mg/kg, iv | 2022 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 71 | WCK 4034: A promising oxazolidinone for treating gram positive infections. |
| AID1056357 | Antibacterial activity against Streptococcus pneumoniae SR26207 clinical isolate assessed as parasite growth inhibition by CLSI broth microdilution method | 2013 | ACS medicinal chemistry letters, Nov-14, Volume: 4, Issue:11 | Potent oxazolidinone antibacterials with heteroaromatic C-ring substructure. |
| AID1710581 | Antibacterial activity against methicillin-resistant Staphylococcus aureus NRS387 assessed as inhibition of visible bacterial growth incubated for 18 to 20 hrs by CLSI method | 2020 | RSC medicinal chemistry, Jan-01, Volume: 11, Issue:1 | Potent trifluoromethoxy, trifluoromethylsulfonyl, trifluoromethylthio and pentafluorosulfanyl containing (1,3,4-oxadiazol-2-yl)benzamides against drug-resistant Gram-positive bacteria. |
| AID530125 | Antimicrobial activity against community acquired methicillin-resistant Staphylococcus aureus 146 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Pharmacodynamic characterization of ceftobiprole in experimental pneumonia caused by phenotypically diverse Staphylococcus aureus strains. |
| AID1680060 | Antibacterial activity against methicillin-resistant Staphylococcus aureus clinical isolate 6 assessed as reduction in bacterial growth incubated for 16 to 20 hrs by CLSI-based broth microdilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Synthesis and antibacterial bioactivities of cationic deacetyl linezolid amphiphiles. |
| AID284983 | Antimicrobial activity against Enterococcus avium at 0.5 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID559800 | Antimicrobial activity against vancomycin-susceptible Staphylococcus aureus assessed as growth inhibition at MIC | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID1520486 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus infected in Kunming mouse dosed subcutaneously at 0.5 and 4.0 hrs postinfection and measured at 7 to 14 days post treatment by Bliss method | |||
| AID308488 | Antibacterial activity against Enterococcus faecalis MGH2 EF1-1 | 2007 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 17, Issue:16 | Synthesis and SAR of novel conformationally restricted oxazolidinones possessing gram-positive and fastidious gram-negative antibacterial activity. Part 2: Amino substitutions on heterocyclic D-ring system. |
| AID530126 | Antimicrobial activity against community acquired methicillin-resistant Staphylococcus aureus 144 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Pharmacodynamic characterization of ceftobiprole in experimental pneumonia caused by phenotypically diverse Staphylococcus aureus strains. |
| AID1653059 | Antibacterial activity against Pseudomonas aeruginosa | 2019 | European journal of medicinal chemistry, Feb-15, Volume: 164 | Isatin derivatives and their anti-bacterial activities. |
| AID1770372 | Antibacterial activity against Staphylococcus aureus ATCC 25923 assessed as decrease of bacterial growth at 32 ug/ml measured up to 24 hrs by Time kill assay | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Modification of 5-methylphenanthridium from benzothiazoles to indoles as potent FtsZ inhibitors: Broadening the antibacterial spectrum toward vancomycin-resistant enterococci. |
| AID283635 | Antimicrobial activity against Staphylococcus aureus RN4220 deltamutS with 23S rRNA G2576U mutation | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | In vitro activity of the oxazolidinone RWJ-416457 against linezolid-resistant and -susceptible staphylococci and enterococci. |
| AID285373 | Half life for simulated intermittent-dosage regimen at 600 mg every 12 hrs using in vitro PK/PD model | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Pharmacokinetic/pharmacodynamic factors influencing emergence of resistance to linezolid in an in vitro model. |
| AID373662 | Antimicrobial activity against panton-valentine leukocidin-negative community-acquired methicillin-resistant Staphylococcus aureus 481 after 37 passages by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID637976 | Antibacterial activity against methicillin-resistant Staphylococcus aureus after overnight incubation by twofold broth dilution technique | 2012 | Bioorganic & medicinal chemistry, Jan-01, Volume: 20, Issue:1 | Efficient microwave-assisted synthesis, antibacterial activity and high fluorescence of 5 benzimidazolyl-2'-deoxyuridines. |
| AID560816 | AUC (0 to 24 hrs) at steady state in human adults with pulmonary tuberculosis at 600 mg administered twice daily for 7 days | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Population pharmacokinetics of linezolid in adults with pulmonary tuberculosis. |
| AID562594 | Antimicrobial activity against vancomycin-nonsusceptible Enterococcus faecalis clinical isolates assessed as resistant isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID1361105 | Bacteriostatic activity against vancomycin-resistant Enterococcus faecium ATCC 700221 clinical isolate after 20 hrs by broth microdilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | N-(1,3,4-oxadiazol-2-yl)benzamide analogs, bacteriostatic agents against methicillin- and vancomycin-resistant bacteria. |
| AID548738 | Antimicrobial activity against Oxacillin-resistant Staphylococcus aureus assessed as percent susceptible isolate by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Activities of dalbavancin against a worldwide collection of 81,673 gram-positive bacterial isolates. |
| AID244849 | Minimum inhibitory concentration against Staphylococcus agalactiae ATCC 13813 | 2004 | Bioorganic & medicinal chemistry letters, Aug-02, Volume: 14, Issue:15 | Synthesis and antibacterial activity of arylpiperazinyl oxazolidinones with diversification of the N-substituents. |
| AID577099 | T>MIC in Enterococcus faecalis Ef1497 in two-compartment pharmacokinetic/pharmacodynamic model at 800 mg, bid administered as 0.5 hr infusion for 2 days | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID1770354 | Bactericidal activity against penicillin-susceptible Bacillus subtilis ATCC 9372 assessed as inhibition of bacterial growth measured after 20 hrs by two-fold microdilution assay | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Modification of 5-methylphenanthridium from benzothiazoles to indoles as potent FtsZ inhibitors: Broadening the antibacterial spectrum toward vancomycin-resistant enterococci. |
| AID1596558 | Antibacterial activity against Cephalosporin resistant Streptococcus pneumoniae ATCC 51916 assessed as reduction in bacterial cell growth incubated for 18 to 20 hrs by broth microdilution method | 2019 | European journal of medicinal chemistry, Aug-01, Volume: 175 | Lipophilic efficient phenylthiazoles with potent undecaprenyl pyrophosphatase inhibitory activity. |
| AID374589 | Antimicrobial activity against Staphylococcus epidermidis MTCC 2639 after 24 hrs by agar dilution assay | 2009 | European journal of medicinal chemistry, Apr, Volume: 44, Issue:4 | Synthesis and antibacterial activity of some new 2,3-dimethoxy-3-hydroxy-2-(1-phenyl-3-aryl-4-pyrazolyl)chromanones. |
| AID1710575 | Antibacterial activity against methicillin-resistant Staphylococcus aureus NRS382 assessed as inhibition of visible bacterial growth incubated for 18 to 20 hrs by CLSI method | 2020 | RSC medicinal chemistry, Jan-01, Volume: 11, Issue:1 | Potent trifluoromethoxy, trifluoromethylsulfonyl, trifluoromethylthio and pentafluorosulfanyl containing (1,3,4-oxadiazol-2-yl)benzamides against drug-resistant Gram-positive bacteria. |
| AID775551 | Antibacterial activity against Enterococcus faecium SR7940 clinical isolate assessed as growth inhibition by broth microdilution method | 2013 | European journal of medicinal chemistry, Nov, Volume: 69 | Synthesis and in vitro/in vivo antibacterial activity of oxazolidinones having thiocarbamate at C-5 on the A-ring and an amide- or urea-substituted [1,2,5]triazepane or [1,2,5]oxadiazepane as the C-ring. |
| AID285003 | Antimicrobial activity against Enterococcus gallinarum at 0.5 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID530052 | Antimicrobial activity against Staphylococcus aureus RN4220 expressing gyrB D437N mutant gene by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Discovery and characterization of QPT-1, the progenitor of a new class of bacterial topoisomerase inhibitors. |
| AID1400051 | Antibacterial activity against Streptococcus pneumoniae ATCC 6301 incubated for 24 hrs under aerobic condition by MABA | 2018 | Bioorganic & medicinal chemistry, 09-15, Volume: 26, Issue:17 | An antimycobacterial pleuromutilin analogue effective against dormant bacilli. |
| AID1126489 | Antimicrobial activity against vancomycin-resistant Enterococcus faecium | 2014 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 24, Issue:8 | Synthesis, antibiotic activity and structure-activity relationship study of some 3-enaminetetramic acids. |
| AID1414194 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 after 24 hrs by broth microdilution based CLSI method | 2018 | European journal of medicinal chemistry, Nov-05, Volume: 159 | Design, synthesis and structure-based optimization of novel isoxazole-containing benzamide derivatives as FtsZ modulators. |
| AID559798 | Antimicrobial activity against vancomycin-susceptible Staphylococcus aureus assessed as growth inhibition at 0.25 times MIC | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID292903 | Inhibition human liver MAOA activity | 2007 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 17, Issue:2 | New carbon-linked azole oxazolidinones with improved potency and pharmacokinetics. |
| AID1079934 | Highest frequency of acute liver toxicity observed during clinical trials, expressed as a percentage. [column '% AIGUE' in source] | |||
| AID283170 | Increase in biofilm formation of Staphylococcus lugdunensis assessed as percent biofilm forming isolates | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | In vitro effects of antimicrobial agents on planktonic and biofilm forms of Staphylococcus lugdunensis clinical isolates. |
| AID1308227 | Antibacterial activity against vancomycin/methicillin-resistant Staphylococcus aureus VRS1 clinical isolate incubated for 16 to 20 hrs by microdilution method | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10 | Structure-Activity Relationship for the 4(3H)-Quinazolinone Antibacterials. |
| AID575049 | Cmin in liver transplant patient plasma at 600 mg, iv or 600 mg, po administered every 12 hrs by HPLC | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Therapeutic drug monitoring of linezolid: a retrospective monocentric analysis. |
| AID285002 | Antimicrobial activity against Enterococcus gallinarum at 0.25 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID522887 | Antibacterial activity against vancomycin-hetero-intermediate Staphylococcus aureus isolate 873 after 24 hrs by modified broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Antistaphylococcal activity of ACHN-490 tested alone and in combination with other agents by time-kill assay. |
| AID562595 | Antimicrobial activity against vancomycin-susceptible Enterococcus faecalis clinical isolates assessed as resistant isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID560807 | Absorption rate constant in human adults with pulmonary tuberculosis at 600 mg administered twice daily for 7 days | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Population pharmacokinetics of linezolid in adults with pulmonary tuberculosis. |
| AID577121 | Tmax in two-compartment pharmacokinetic/pharmacodynamic model at 200 mg, bid administered as 0.5 hr infusion over 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID383557 | Antibacterial activity against Streptococcus pyogenes ATCC 14289 by broth microdilution technique | 2008 | European journal of medicinal chemistry, Apr, Volume: 43, Issue:4 | Synthesis and in vitro antibacterial activities of novel oxazolidinones. |
| AID1710583 | Antibacterial activity against methicillin-resistant Staphylococcus aureus NRS484 assessed as inhibition of visible bacterial growth incubated for 18 to 20 hrs by CLSI method | 2020 | RSC medicinal chemistry, Jan-01, Volume: 11, Issue:1 | Potent trifluoromethoxy, trifluoromethylsulfonyl, trifluoromethylthio and pentafluorosulfanyl containing (1,3,4-oxadiazol-2-yl)benzamides against drug-resistant Gram-positive bacteria. |
| AID1547700 | Antibacterial activity against Staphylococcus aureus ATCC 29213 by broth microdilution method | 2020 | ACS medicinal chemistry letters, Mar-12, Volume: 11, Issue:3 | Structure-Activity Relationship for the Oxadiazole Class of Antibacterials. |
| AID449618 | Antibacterial activity against methicillin-resistant Staphylococcus epidermidis by agar dilution method | 2009 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 19, Issue:18 | Water-soluble phosphate prodrugs of pleuromutilin analogues with potent in vivo antibacterial activity against Gram-positive pathogens. |
| AID1603309 | Antimicrobial activity against methicillin-sensitive Staphylococcus aureus ATCC 29213 measured after 16 hrs by broth microdilution method | 2019 | ACS medicinal chemistry letters, Mar-14, Volume: 10, Issue:3 | Expanded Structure-Activity Studies of Lipoxazolidinone Antibiotics. |
| AID534510 | Drug level in human THP1 cells at 250 mg/L after 30 mins at pH 6 | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Cellular pharmacokinetics of the novel biaryloxazolidinone radezolid in phagocytic cells: studies with macrophages and polymorphonuclear neutrophils. |
| AID1680053 | Antibacterial activity against carbapenem-resistant Klebsiella pneumoniae clinical isolate 3 assessed as reduction in bacterial growth incubated for 16 to 20 hrs by CLSI-based broth microdilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Synthesis and antibacterial bioactivities of cationic deacetyl linezolid amphiphiles. |
| AID522882 | Antibacterial activity against vancomycin-resistant Staphylococcus aureus isolate 557 after 24 hrs by modified broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Antistaphylococcal activity of ACHN-490 tested alone and in combination with other agents by time-kill assay. |
| AID285012 | Antimicrobial activity against Enterococcus hirae at 2 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID1139116 | Antimicrobial activity against Streptococcus pneumoniae | 2014 | Bioorganic & medicinal chemistry letters, May-01, Volume: 24, Issue:9 | Successful application of serum shift prediction models to the design of dual targeting inhibitors of bacterial gyrase B and topoisomerase IV with improved in vivo efficacy. |
| AID130381 | In vivo efficacy of compound to protect the Staphylococcus aureus UC9213 infected mouse from death after sc administration | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | The effect of remote chirality on the antibacterial activity of indolinyl, tetrahydroquinolyl and dihydrobenzoxazinyl oxazolidinones. |
| AID533661 | Antimicrobial activity against Staphylococcus aureus RN4220 harboring plasmid CU1 | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic characterization of Vga ABC proteins conferring reduced susceptibility to pleuromutilins in Staphylococcus aureus. |
| AID390334 | Antimicrobial activity against Escherichia coli 1411 | 2008 | Journal of natural products, Dec, Volume: 71, Issue:12 | Citreamicins with potent gram-positive activity. |
| AID373307 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus clinical isolate after 18 hrs by NCCLS M7-A4 method | 2009 | European journal of medicinal chemistry, Mar, Volume: 44, Issue:3 | Synthesis, antibacterial and anticonvulsant evaluations of some cyclic enaminones. |
| AID574068 | fCmax in CF-1 mouse at 10 mg/kg, po | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | In vivo activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. |
| AID391847 | Antibacterial activity against Haemophilus influenzae IID983 by agar dilution method | 2008 | Journal of medicinal chemistry, Oct-23, Volume: 51, Issue:20 | Synthesis and structure-activity relationship studies of highly potent novel oxazolidinone antibacterials. |
| AID730749 | Antibacterial activity against macrolides, lincosamides, and streptogramin B-resistant Streptococcus pyogenes 1304-00 assessed as growth inhibition | 2013 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 23, Issue:6 | Novel 3-O-carbamoyl erythromycin A derivatives (carbamolides) with activity against resistant staphylococcal and streptococcal isolates. |
| AID1596544 | Antibacterial activity against methicillin resistant Staphylococcus aureus USA400 assessed as reduction in bacterial cell growth incubated for 18 to 20 hrs by broth microdilution method | 2019 | European journal of medicinal chemistry, Aug-01, Volume: 175 | Lipophilic efficient phenylthiazoles with potent undecaprenyl pyrophosphatase inhibitory activity. |
| AID284949 | Antimicrobial activity against Bacillus spp. at 1 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID373824 | Antimicrobial activity against panton-valentine leukocidin-negative community-acquired methicillin-resistant Staphylococcus aureus 481 after 14 passages with CG400549 measured after 10 antibiotic-free subculture by multi-step resistance selection techniqu | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID558509 | Antimicrobial activity against heterogeneous vancomycin-intermediate Staphylococcus aureus 168 measured on day 25 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID1180569 | Antimicrobial activity against Staphylococcus aureus ARC516 by broth microdilution/CLSI method | 2014 | Journal of medicinal chemistry, Jul-24, Volume: 57, Issue:14 | Optimization of pyrrolamide topoisomerase II inhibitors toward identification of an antibacterial clinical candidate (AZD5099). |
| AID565231 | Antimicrobial activity against Mycobacterium chelonae 9917 harboring pZS01 carrying mspA gene by resazurine microtiter assay | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Role of porins in the susceptibility of Mycobacterium smegmatis and Mycobacterium chelonae to aldehyde-based disinfectants and drugs. |
| AID574083 | Ratio of fAUC (24 hrs) for community-associated methicillin-resistant Staphylococcus aureus OC8525 infected iv dosed mouse to MIC for community-associated methicillin-resistant Staphylococcus aureus OC8525 | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | In vivo activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. |
| AID373309 | Antibacterial activity against methicillin-sensitive coagulase-negative Staphylococcus clinical isolate after 18 hrs by NCCLS M7-A4 method | 2009 | European journal of medicinal chemistry, Mar, Volume: 44, Issue:3 | Synthesis, antibacterial and anticonvulsant evaluations of some cyclic enaminones. |
| AID559799 | Antimicrobial activity against vancomycin-susceptible Staphylococcus aureus assessed as growth inhibition at 0.5 times MIC | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID283390 | Antimicrobial activity against Nocardia cyriacigeorgica after 72 hrs by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | In vitro activities of tigecycline and eight other antimicrobials against different Nocardia species identified by molecular methods. |
| AID292612 | Antimicrobial activity against Streptococcus pneumoniae ATCC 6303 by agar dilution method | 2007 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 17, Issue:17 | Synthesis and antibacterial activity of novel oxazolidinones with methylene oxygen- and methylene sulfur-linked substituents at C5-position. |
| AID565079 | Antibacterial activity against community-acquired methicillin-resistant Staphylococcus aureus 147 by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Pharmacodynamic profile of tigecycline against methicillin-resistant Staphylococcus aureus in an experimental pneumonia model. |
| AID303969 | Antibacterial activity against methicillin-resistant Staphylococcus aureus SA1417 by micro-broth technology | 2007 | Journal of medicinal chemistry, Nov-29, Volume: 50, Issue:24 | Antibacterial oxazolidinones possessing a novel C-5 side chain. (5R)-trans-3-[3-Fluoro-4- (1-oxotetrahydrothiopyran-4-yl)phenyl]-2- oxooxazolidine-5-carboxylic acid amide (PF-00422602), a new lead compound. |
| AID569346 | Antibacterial activity against penicillin-susceptible Streptococcus pneumoniae by agar dilution method | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 | Design, synthesis and antibacterial activity of 3-methylenepyrrolidine formyl hydroxyamino derivatives as novel peptide deformylase inhibitors. |
| AID730744 | Antibacterial activity against methicillin-resistant Staphylococcus aureus 1279-07 harboring cfr gene assessed as growth inhibition | 2013 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 23, Issue:6 | Novel 3-O-carbamoyl erythromycin A derivatives (carbamolides) with activity against resistant staphylococcal and streptococcal isolates. |
| AID563321 | Antibacterial activity against vancomycin-susceptible Enterococcus faecalis EF 12704 infected in New Zealand White rabbit assessed as reduction of bacterial count in aortic valve vegetations at 10 mg/kg, administered through ear vein every 12 hrs for 4 da | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | In vivo activity of a novel anti-methicillin-resistant Staphylococcus aureus cephalosporin, ceftaroline, against vancomycin-susceptible and -resistant Enterococcus faecalis strains in a rabbit endocarditis model: a comparative study with linezolid and van |
| AID1162168 | Antitubercular activity against Mycobacterium tuberculosis assessed as growth inhibition | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | SAR analysis of new anti-TB drugs currently in pre-clinical and clinical development. |
| AID523789 | Antimicrobial activity against oxacillin-resistant Staphylococcus aureus assessed as inhibition of microbial growth at 2 ug/ml by CLSI method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative activities of TR-700 (torezolid) against staphylococcal blood isolates collected in Spain. |
| AID1207747 | Inhibition of Cav1.2 current measured using QPatch automatic path clamp system in CHO cells expressing Cav1.2, beta-2 and alpha-2/delta-1 subunits | 2013 | Scientific reports, , Volume: 3 | MICE models: superior to the HERG model in predicting Torsade de Pointes. |
| AID1400755 | Antibiofilm activity against vancomycin-resistant Enterococcus faecium ATCC 700221 after 24 hrs by calgary biofilm device-based assay | 2017 | MedChemComm, Apr-01, Volume: 8, Issue:4 | Microwave-enhanced Friedländer synthesis for the rapid assembly of halogenated quinolines with antibacterial and biofilm eradication activities against drug resistant and tolerant bacteria. |
| AID292610 | Antimicrobial activity against vancomycin-resistant Enterococcus faecium 6A by agar dilution method | 2007 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 17, Issue:17 | Synthesis and antibacterial activity of novel oxazolidinones with methylene oxygen- and methylene sulfur-linked substituents at C5-position. |
| AID1904081 | Antibacterial activity against Enterococcus faecium NCTC 7171 | 2022 | European journal of medicinal chemistry, Apr-05, Volume: 233 | Alternative approaches utilizing click chemistry to develop next-generation analogs of solithromycin. |
| AID1519259 | Intrinsic clearance in human liver microsomes | 2019 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 29, Issue:23 | Synthesis and antibacterial evaluation of novel oxazolidinone derivatives containing a piperidinyl moiety. |
| AID207725 | Minimum inhibitory concentration against Staphylococcus aureus broth | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | Synthesis and antibacterial activity of pyrroloaryl-substituted oxazolidinones. |
| AID775550 | Antibacterial activity against Moraxella catarrhalis SR26840 clinical isolate assessed as growth inhibition by broth microdilution method | 2013 | European journal of medicinal chemistry, Nov, Volume: 69 | Synthesis and in vitro/in vivo antibacterial activity of oxazolidinones having thiocarbamate at C-5 on the A-ring and an amide- or urea-substituted [1,2,5]triazepane or [1,2,5]oxadiazepane as the C-ring. |
| AID1400037 | Bactericidal activity against Staphylococcus aureus incubated for 24 hrs under aerobic condition by MABA | 2018 | Bioorganic & medicinal chemistry, 09-15, Volume: 26, Issue:17 | An antimycobacterial pleuromutilin analogue effective against dormant bacilli. |
| AID560815 | Tmax in human adults with pulmonary tuberculosis at 600 mg administered twice daily for 7 days | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Population pharmacokinetics of linezolid in adults with pulmonary tuberculosis. |
| AID196897 | Inhibition of mitochondrial protein synthesis (MPS) in rat heart mitochondria | 2002 | Bioorganic & medicinal chemistry letters, Aug-19, Volume: 12, Issue:16 | The synthesis and biological evaluation of a novel series of antimicrobials of the oxazolidinone class. |
| AID560823 | Ratio of AUC (0 to 12 hrs) in human adults with pulmonary tuberculosis at 600 mg administered once daily for 5 days to MIC for Mycobacterium tuberculosis | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Population pharmacokinetics of linezolid in adults with pulmonary tuberculosis. |
| AID67092 | Compound was evaluated for minimum inhibitory concentration against Enterococcus faecalis 50 strain | 2002 | Bioorganic & medicinal chemistry letters, Mar-25, Volume: 12, Issue:6 | Synthesis and antibacterial activity of linezolid analogues. |
| AID388041 | Antibacterial activity against penicillin-susceptible Streptococcus pneumoniae CL2883 after 18 to 20 hrs by serial dilution method | 2008 | Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19 | Isolation, structure, and antibacterial activity of thiazomycin A, a potent thiazolyl peptide antibiotic from Amycolatopsis fastidiosa. |
| AID112683 | In vivo antibacterial activity against Enterococcus faecium strain UC 15090 administered perorally in mice | 1996 | Journal of medicinal chemistry, Feb-02, Volume: 39, Issue:3 | Synthesis and antibacterial activity of U-100592 and U-100766, two oxazolidinone antibacterial agents for the potential treatment of multidrug-resistant gram-positive bacterial infections. |
| AID520225 | Antimicrobial activity against Enterococcus faecium A8767 | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID1594356 | Antibacterial activity against methicillin-resistant Staphylococcus aureus NRS123 USA400 after 18 to 24 hrs by broth microdilution assay | 2019 | Bioorganic & medicinal chemistry, 05-01, Volume: 27, Issue:9 | Second-generation aryl isonitrile compounds targeting multidrug-resistant Staphylococcus aureus. |
| AID561338 | Antimicrobial activity against Staphylococcus aureus isolate UAMS-1 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Impact of sarA on antibiotic susceptibility of Staphylococcus aureus in a catheter-associated in vitro model of biofilm formation. |
| AID583406 | Antimicrobial activity against vancomycin-resistant Staphylococcus aureus isolate MI assessed as bacterial count at 32 times MIC after 24 hrs by colony counting method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | In vitro activity of the new multivalent glycopeptide-cephalosporin antibiotic TD-1792 against vancomycin-nonsusceptible Staphylococcus isolates. |
| AID575079 | Antimicrobial activity against Streptococcus pneumoniae serotype 7F assessed as percent susceptible isolates by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID695236 | Cytotoxicity against human Hep2 cell line after 72 hrs | 2011 | Journal of medicinal chemistry, May-12, Volume: 54, Issue:9 | Selenophene-containing inhibitors of type IIA bacterial topoisomerases. |
| AID542696 | fCmax in Bacillus anthracis infected in vitro hollow fiber PK/PD model at simulated dose of 500 mg /day administered once every 24 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID559776 | Antimicrobial activity against heterogeneous vancomycin-intermediate Staphylococcus aureus assessed as resistant isolates by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID429421 | Antibacterial activity against methicillin resistant coagulase-negative Staphylococcus by agar dilution method | 2009 | European journal of medicinal chemistry, Aug, Volume: 44, Issue:8 | Synthesis and antibacterial activity of novel 5-(4-methyl-1H-1,2,3-triazole) methyl oxazolidinones. |
| AID1609267 | Antibacterial activity against cephalosporin-resistant Streptococcus pneumoniae ATCC 51916 after 18 to 20 hrs by CLSI-based broth microdilution assay | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Phenylthiazoles with nitrogenous side chain: An approach to overcome molecular obesity. |
| AID1692900 | Antibacterial activity against Staphylococcus aureus ATCC 29213 | 2021 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 32 | Design, synthesis and antibacterial evaluation of novel oxazolidinone derivatives nitrogen-containing fused heterocyclic moiety. |
| AID541093 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 infected in Albino guiena pig assessed as inhibition of bacterial growth in cage fluid at 75 mg/kg measured on day 10 postinfection compared to the bacterial growth on d | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Linezolid alone or combined with rifampin against methicillin-resistant Staphylococcus aureus in experimental foreign-body infection. |
| AID206226 | In vitro antibacterial activity against Staphylococcus epidermis ATCC 1228 | 2003 | Bioorganic & medicinal chemistry letters, Jul-07, Volume: 13, Issue:13 | Synthesis and in vitro activity of new methylenepiperidinyl and methylenepyrrolidinyl oxazolidinone antibacterial agents. |
| AID560805 | Tmax in human adults with pulmonary tuberculosis at 600 mg administered daily for 7 days | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Population pharmacokinetics of linezolid in adults with pulmonary tuberculosis. |
| AID1574838 | Antibacterial activity against linezolid-resistant Enterococcus faecalis by broth liquid microdilution method | 2019 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 29, Issue:3 | Design and synthesis of biaryloxazolidinone derivatives containing a rhodanine or thiohydantoin moiety as novel antibacterial agents against Gram-positive bacteria. |
| AID1861529 | AUC in Wistar rat at 30 mg/kg, iv | 2022 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 71 | WCK 4034: A promising oxazolidinone for treating gram positive infections. |
| AID520764 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus infected in New Zealand rabbit osteomyelitis model assessed as improvement in extent of bone remodeling at 60 mg/kg, po administered every 8 hrs for 4 weeks measured on week 2 post | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Efficacies of ceftobiprole medocaril and comparators in a rabbit model of osteomyelitis due to methicillin-resistant Staphylococcus aureus. |
| AID323822 | Reduction in bioluminescent methicillin-sensitive Staphylococcus aureus Xen29 in neutropenic CD1 mouse with peritonitis at 100 mg/kg, po after 4 hrs relative to control | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Rapid bactericidal activity of daptomycin against methicillin-resistant and methicillin-susceptible Staphylococcus aureus peritonitis in mice as measured with bioluminescent bacteria. |
| AID410206 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis by broth micro dilution method | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24 | A facile synthesis, antibacterial, and antitubercular studies of some piperidin-4-one and tetrahydropyridine derivatives. |
| AID1194836 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae incubated for 16 hrs by agar dilution method | 2015 | Bioorganic & medicinal chemistry letters, , Volume: 25, Issue:10 | Synthesis and structure-activity relationship studies of novel [6,6,5] tricyclic oxazolidinone derivatives as potential antibacterial agents. |
| AID559796 | Antimicrobial activity against heterogeneous vancomycin-intermediate Staphylococcus aureus assessed as growth inhibition at 16 times MIC | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID572282 | Antimicrobial activity against methicillin susceptible Staphylococcus aureus ATCC 49951 infected in po dosed NMRI mouse treated 1 and 5 hrs post infection | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vivo characterization of the peptide deformylase inhibitor LBM415 in murine infection models. |
| AID295162 | Antibacterial activity against methicillin-resistant Staphylococcus epidermidis 03427 infected po dosed KunMing mouse | 2007 | European journal of medicinal chemistry, Aug, Volume: 42, Issue:8 | Synthesis and antibacterial activity of oxazolidinones containing triazolyl group. |
| AID555498 | Antibacterial activity against methicillin-resistant and vancomycin-resistant Staphylococcus aureus VRS1 after 50 passages by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Antistaphylococcal activity of dihydrophthalazine antifolates, a family of novel antibacterial drugs. |
| AID205744 | In vitro antibacterial activity against Staphylococcus epidermidisMR 887E (S. e. MR) | 2003 | Bioorganic & medicinal chemistry letters, Nov-17, Volume: 13, Issue:22 | Synthesis and in vitro activity of novel isoxazolyl tetrahydropyridinyl oxazolidinone antibacterial agents. |
| AID522927 | Antibacterial activity against community-acquired methicillin-resistant panton-valentine leukocidin-negative Staphylococcus aureus isolate 1470 after 24 hrs by modified broth macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Antistaphylococcal activity of ACHN-490 tested alone and in combination with other agents by time-kill assay. |
| AID370010 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus Smith infected in C3H mouse assessed as eradication at 3.12 mg/kg/day, po administered within 15 mins of infection assessed per gram of kidney measured after 48 hrs by organ burd | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vivo efficacy of a novel oxazolidinone compound in two mouse models of infection. |
| AID12181 | Area under curve was determined in male rat | 2003 | Bioorganic & medicinal chemistry letters, Jul-07, Volume: 13, Issue:13 | Synthesis and in vitro activity of new methylenepiperidinyl and methylenepyrrolidinyl oxazolidinone antibacterial agents. |
| AID1415064 | Antibacterial activity against Staphylococcus aureus ATCC 29213 after 16 hrs by agar dilution method | 2018 | Journal of medicinal chemistry, 12-27, Volume: 61, Issue:24 | Semisynthesis of Platensimycin Derivatives with Antibiotic Activities in Mice via Suzuki-Miyaura Cross-Coupling Reactions. |
| AID1861520 | Antibacterial activity against Streptococcus pneumoniae ATCC 49619 incubated for 18 hrs by CLSI protocol based two-fold serial agar dilution method | 2022 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 71 | WCK 4034: A promising oxazolidinone for treating gram positive infections. |
| AID535775 | Antimicrobial activity against Mycobacterium ulcerans 1059 harboring pTY60K containing pMH94 carrying the luxAB gene under the hsp60 promoter after 14 days determined according to RLU count by real-time luminescence method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Rapid assessment of antibacterial activity against Mycobacterium ulcerans by using recombinant luminescent strains. |
| AID574084 | Ratio of fAUC (24 hrs) for penicillin-susceptible Streptococcus pneumoniae ATCC 6301 infected po dosed mouse to MIC for penicillin-susceptible Streptococcus pneumoniae ATCC 6301 | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | In vivo activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. |
| AID1374175 | Antibacterial activity against Enterococcus faecalis ATCC 33186 incubated at 37 degC for 20 hrs by agar dilution method | 2018 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4 | Design, synthesis and antibacterial evaluation of honokiol derivatives. |
| AID573866 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus ATCC 13709 infected in po dosed Swiss Webster mouse administered at 1 to 3 hrs post infection measured after 3 days | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | In vivo activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. |
| AID1327118 | Antitubercular activity against dormant stage Mycobacterium tuberculosis H37Ra at 10 ug/ml measured after 12 days by XTT assay | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Design, synthesis and biological evaluation of novel azaspiro analogs of linezolid as antibacterial and antitubercular agents. |
| AID1778649 | Antibacterial activity against penicillin-susceptible Pseudomonas aeruginosa ATCC27853 assessed as bacterial growth inhibition incubated for 24 hrs by CLSI protocol based broth microdilution method | 2021 | European journal of medicinal chemistry, Oct-05, Volume: 221 | Design, synthesis and evaluation of novel 9-arylalkyl-10-methylacridinium derivatives as highly potent FtsZ-targeting antibacterial agents. |
| AID562589 | Antimicrobial activity against vancomycin-nonsusceptible Enterococcus faecium clinical isolates assessed as resistant isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID373749 | Antimicrobial activity against mupirocin-susceptible methicillin-resistant Staphylococcus aureus assessed as resistant rate by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Mupirocin-resistant, methicillin-resistant Staphylococcus aureus strains in Canadian hospitals. |
| AID542388 | Antimicrobial activity against Staphylococcus aureus RN4220 transformed with Staphylococcus aureus ST398 plasmid pSCFS3 carrying cfr and fexA genes | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Methicillin-resistant and -susceptible Staphylococcus aureus strains of clonal lineages ST398 and ST9 from swine carry the multidrug resistance gene cfr. |
| AID1060729 | Antibacterial activity against Staphylococcus aureus ATCC 29213 by broth microdilution method | 2014 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 24, Issue:1 | Design, synthesis and structure-activity relationships of substituted oxazole-benzamide antibacterial inhibitors of FtsZ. |
| AID1265127 | Reversible inhibition of human MAO-B | 2015 | European journal of medicinal chemistry, Dec-01, Volume: 106 | Synthesis and biological evaluation of novel 5-(hydroxamic acid)methyl oxazolidinone derivatives. |
| AID319150 | Oral bioavailability in dog at 25 mg/kg | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7 | Linezolid (ZYVOX), the first member of a completely new class of antibacterial agents for treatment of serious gram-positive infections. |
| AID1611121 | Antibacterial activity against linezolid-resistant Enterococcus faecalis CLSI-based double dilution method | 2019 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 29, Issue:23 | Design and synthesis of biaryloxazolidinone derivatives containing amide or acrylamide moiety as novel antibacterial agents against Gram-positive bacteria. |
| AID548737 | Antimicrobial activity against Oxacillin-susceptible Staphylococcus aureus assessed as percent susceptible isolate by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Activities of dalbavancin against a worldwide collection of 81,673 gram-positive bacterial isolates. |
| AID349311 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after 18 hrs by agar dilution method in presence of 50% human plasma | 2008 | European journal of medicinal chemistry, May, Volume: 43, Issue:5 | Synthesis and structure-antibacterial activity of triazolyl oxazolidinones containing long chain acyl moiety. |
| AID581023 | Inhibition of RNA synthesis in Staphylococcus aureus ATCC 25923 assessed as incorporation of [3H]uridine at 2 ug/ml by liquid scintillation counter | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Mode of action of Ranbezolid against staphylococci and structural modeling studies of its interaction with ribosomes. |
| AID1723495 | Antibacterial activity against Enterococcus faecium NR-31914 incubated for 18 to 20 hrs under aerobic condition by CLSI protocol based broth microdilution assay | |||
| AID283616 | Antimicrobial activity against Enterococcus faecium 28 with heterozygous 23S rRNA G2576U mutation | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | In vitro activity of the oxazolidinone RWJ-416457 against linezolid-resistant and -susceptible staphylococci and enterococci. |
| AID520020 | Antimicrobial activity against Enterococcus faecalis ATCC 29212 | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID1520444 | Antibacterial activity against methicillin-resistant Staphylococcus aureus after 18 to 20 hrs by CLSI-protocol based broth microdilution method | |||
| AID528974 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus isolated from ICU patient respiratory tract assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID1710577 | Antibacterial activity against methicillin-resistant Staphylococcus aureus NRS384 assessed as inhibition of visible bacterial growth incubated for 18 to 20 hrs by CLSI method | 2020 | RSC medicinal chemistry, Jan-01, Volume: 11, Issue:1 | Potent trifluoromethoxy, trifluoromethylsulfonyl, trifluoromethylthio and pentafluorosulfanyl containing (1,3,4-oxadiazol-2-yl)benzamides against drug-resistant Gram-positive bacteria. |
| AID205729 | In vitro antibacterial activity against Staphylococcus epidermidis strains UC12084, 30031, and CDC-CNS90 (SE); range is 1-2 | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | New antibacterial tetrahydro-4(2H)-thiopyran and thiomorpholine S-oxide and S,S-dioxide phenyloxazolidinones. |
| AID1649286 | Antibacterial activity against Vancomycin-resistant Enterococcus faecalis SR23630 (VanB) assessed as inhibition of bacterial growth incubated for 20 hrs by microdilution broth method | |||
| AID1167997 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis clinical isolate 6093 after overnight incubation by two-fold serial dilution method | 2014 | Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21 | Synthesis and biological evaluation of novel peptide BF2 as an antibacterial agent against clinical isolates of vancomycin-resistant enterococci. |
| AID1596569 | Bactericidal activity against vancomycin resistant Enterococcus faecium ATCC 700221 assessed as reduction in bacterial cell growth incubated for 18 to 20 hrs followed by re-plating on tryptic soy agar plates at 37 degC for 18 hrs by broth microdilution as | 2019 | European journal of medicinal chemistry, Aug-01, Volume: 175 | Lipophilic efficient phenylthiazoles with potent undecaprenyl pyrophosphatase inhibitory activity. |
| AID308913 | Antibacterial activity against Staphylococcus epidermidis ATCC 12228 by broth microdilution method | 2007 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 17, Issue:18 | Synthesis and in vitro antibacterial activity of novel methylamino piperidinyl oxazolidinones. |
| AID759684 | Cytotoxicity against human HepG2 cells assessed as reduction of cell viability at 5 to 400 ug/ml by MTT assay | 2013 | European journal of medicinal chemistry, Jul, Volume: 65 | New linezolid-like 1,2,4-oxadiazoles active against Gram-positive multiresistant pathogens. |
| AID523296 | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv infected in B6 mouse assessed as assessed as lowest concentration to reduce bacterial burden in lungs to level of reduction achieved with higher doses orally treated in water-1% methylcel | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Fast standardized therapeutic-efficacy assay for drug discovery against tuberculosis. |
| AID1407926 | Antibacterial activity against Acinetobacter baumannii ARC3495 after 24 hrs by broth microdilution method | 2018 | European journal of medicinal chemistry, Sep-05, Volume: 157 | Discovery of dual GyrB/ParE inhibitors active against Gram-negative bacteria. |
| AID319982 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus ATCC 33591 | 2008 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 18, Issue:2 | Synthesis, SAR, and antibacterial activity of novel oxazolidinone analogues possessing urea functionality. |
| AID525138 | Antibacterial activity against Staphylococcus aureus RN4220 after 18 to 24 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Delayed development of linezolid resistance in Staphylococcus aureus following exposure to low levels of antimicrobial agents. |
| AID573126 | Antibacterial activity against penicillin-susceptible Streptococcus pneumoniae assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID558530 | Antimicrobial activity against heterogeneous vancomycin-intermediate Staphylococcus aureus 873 measured on day 35 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID535025 | Antimicrobial activity against vancomycin intermediate Staphylococcus aureus NRS-24 expressing SCCmec type 2 element by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | In vitro activity of ceftaroline against community-associated methicillin-resistant, vancomycin-intermediate, vancomycin-resistant, and daptomycin-nonsusceptible Staphylococcus aureus isolates. |
| AID1308225 | Antibacterial activity against mecA-positive multidrug resistant Staphylococcus aureus NRS119 incubated for 16 to 20 hrs by microdilution method | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10 | Structure-Activity Relationship for the 4(3H)-Quinazolinone Antibacterials. |
| AID396026 | Antibacterial activity against drug-resistant Enterobacter cloacae EcDC64 isolate expressing AcrAB-TolC efflux pump by Etest | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Cloning, nucleotide sequencing, and analysis of the AcrAB-TolC efflux pump of Enterobacter cloacae and determination of its involvement in antibiotic resistance in a clinical isolate. |
| AID645033 | Antibacterial activity against erythromycin-resistant Streptococcus pyogenes 6 after 16 to 20 hrs by microbroth dilution method | 2012 | European journal of medicinal chemistry, Apr, Volume: 50 | Synthesis and preliminary antibacterial evaluation of Linezolid-like 1,2,4-oxadiazole derivatives. |
| AID1723496 | Antibacterial activity against Enterococcus faecium NR-31916 incubated for 18 to 20 hrs under aerobic condition by CLSI protocol based broth microdilution assay | |||
| AID245388 | Minimum inhibitory concentration against methicillin resistant Staphylococcus aureus (strain A27223) in absence of calf serum | 2004 | Bioorganic & medicinal chemistry letters, Sep-20, Volume: 14, Issue:18 | Discovery of isoxazolinone antibacterial agents. Nitrogen as a replacement for the stereogenic center found in oxazolidinone antibacterials. |
| AID535031 | Antimicrobial activity against vancomycin intermediate Staphylococcus aureus NRS-74 expressing SCCmec type 2 element by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | In vitro activity of ceftaroline against community-associated methicillin-resistant, vancomycin-intermediate, vancomycin-resistant, and daptomycin-nonsusceptible Staphylococcus aureus isolates. |
| AID560585 | Bactericidal activity against vancomycin-resistant Enterococcus faecium 1059060 expressing vanA gene assessed as change in bacterial count at 4 ug/ml by time-kill assay | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Impact of human serum albumin on oritavancin in vitro activity against enterococci. |
| AID1504618 | Antibacterial activity against Staphylococcus aureus ATCC 29213 by microbroth dilution method | 2017 | ACS medicinal chemistry letters, Nov-09, Volume: 8, Issue:11 | Design, Synthesis, and Antibacterial Evaluation of Oxazolidinones with Fused Heterocyclic C-Ring Substructure. |
| AID516162 | Antibacterial activity against methicillin-resistant Staphylococcus aureus clinical isolates assessed as susceptible isolates by EUCAST method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | In vitro activity of telavancin against a contemporary worldwide collection of Staphylococcus aureus isolates. |
| AID1877883 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus Newman assessed as bacterial growth inhibition | 2022 | Bioorganic & medicinal chemistry letters, 03-01, Volume: 59 | Novel 2,4-disubstituted quinazoline analogs as antibacterial agents with improved cytotoxicity profile: Modification of the benzenoid part. |
| AID533388 | Antimicrobial activity against Clostridium difficile assessed as resistant isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activities of doripenem, a new broad-spectrum carbapenem, against recently collected clinical anaerobic isolates, with emphasis on the Bacteroides fragilis group. |
| AID255578 | In vitro minimum inhibitory concentration against methicillin-resistant Staphylococcus aureus 562 after incubation in air at 35 degree C for 24 hr using agar dilution method | 2005 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 15, Issue:19 | Synthesis and SAR of novel oxazolidinones: discovery of ranbezolid. |
| AID1547709 | Antibacterial activity against vancomycin-resistant Staphylococcus aureus VRS1 clinical isolate by broth microdilution method | 2020 | ACS medicinal chemistry letters, Mar-12, Volume: 11, Issue:3 | Structure-Activity Relationship for the Oxadiazole Class of Antibacterials. |
| AID1501366 | Bactericidal activity against methicillin-resistant Staphylococcus aureus USA200 NRS383 incubated for 20 hrs followed by replating on tryptic soy agar plates and further incubated for 18 hrs by broth microdilution assay | 2017 | European journal of medicinal chemistry, Oct-20, Volume: 139 | Arylthiazole antibiotics targeting intracellular methicillin-resistant Staphylococcus aureus (MRSA) that interfere with bacterial cell wall synthesis. |
| AID318355 | Antibacterial activity against methicillin and linezolid-resistant Staphylococcus aureus | 2007 | Proceedings of the National Academy of Sciences of the United States of America, May-01, Volume: 104, Issue:18 | Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties. |
| AID308731 | Antibacterial activity against Moraxella catarrhalis BC-3531 by micro-broth method | 2007 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 17, Issue:16 | Synthesis and SAR of novel conformationally-restricted oxazolidinones possessing gram-positive and fastidious gram-negative antibacterial activity. Part 1: Substituted pyrazoles. |
| AID1435930 | Bactericidal activity against methicillin-resistant Staphylococcus aureus USA400 NRS123 clinical isolate after 24 hrs | 2017 | European journal of medicinal chemistry, Jan-27, Volume: 126 | Phenylthiazole antibiotics: A metabolism-guided approach to overcome short duration of action. |
| AID262226 | Antibacterial activity against Bacillus pumilus ATCC 14348 | 2006 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 16, Issue:6 | Novel 4-N-substituted aryl pent-2-ene-1,4-dione derivatives of piperazinyloxazolidinones as antibacterials. |
| AID1594358 | Antibacterial activity against methicillin-resistant Staphylococcus aureus NRS119 after 18 to 24 hrs by broth microdilution assay | 2019 | Bioorganic & medicinal chemistry, 05-01, Volume: 27, Issue:9 | Second-generation aryl isonitrile compounds targeting multidrug-resistant Staphylococcus aureus. |
| AID1760594 | Antibacterial activity against Staphylococcus aureus 29213 assessed as inhibition of bacterial growth measured after 24 hrs | 2021 | European journal of medicinal chemistry, Feb-05, Volume: 211 | Installation of an aryl boronic acid function into the external section of N-aryl-oxazolidinones: Synthesis and antimicrobial evaluation. |
| AID562194 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus 540 measured after 10 antibiotic-free subculturing by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID1308229 | Antibacterial activity against Staphylococcus epidermidis ATCC 35547 incubated for 16 to 20 hrs by microdilution method | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10 | Structure-Activity Relationship for the 4(3H)-Quinazolinone Antibacterials. |
| AID319171 | Protection against vancomycin-resistant Enterococcus infection in pneumonia patient | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7 | Linezolid (ZYVOX), the first member of a completely new class of antibacterial agents for treatment of serious gram-positive infections. |
| AID558718 | Antimicrobial activity against heterogeneous vancomycin-intermediate Staphylococcus aureus 873 measured on day 45 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID1594366 | Antibacterial activity against vancomycin-resistant Enterococcus faecium ATCC 700221 after 18 to 24 hrs by broth microdilution assay | 2019 | Bioorganic & medicinal chemistry, 05-01, Volume: 27, Issue:9 | Second-generation aryl isonitrile compounds targeting multidrug-resistant Staphylococcus aureus. |
| AID1852673 | Antibacterial activity against multidrug resistant Acinetobacter baumannii Ab5075 assessed as inhibition of bacterial growth incubated for 24 hrs in MHI medium by twofold serial dilution method | |||
| AID1154477 | Antibacterial activity against of methicillin-resistant Staphylococcus aureus ATCC 33591 infected in iv dosed neutropenic mouse assessed as host survival administered 1 hr after infection measured after 24 hrs | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | Design, synthesis, and structure-activity relationship studies of novel thioether pleuromutilin derivatives as potent antibacterial agents. |
| AID558521 | Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus 555 measured on day 30 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID303914 | Antibacterial activity against vancomycin-resistant Enterococcus faecium 6A after 24 hrs by agar dilution method | 2007 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 17, Issue:24 | Synthesis and antibacterial activity of potent heterocyclic oxazolidinones and the identification of RBx 8700. |
| AID284995 | Antimicrobial activity against Enterococcus durans at 0.12 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID1493823 | Antibacterial activity against Staphylococcus aureus NRS119 clinical isolate after 18 to 20 hrs by broth microdilution method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Biphenylthiazole antibiotics with an oxadiazole linker: An approach to improve physicochemical properties and oral bioavailability. |
| AID1519266 | Antibacterial activity agianst linezolid-resistant Enterococcus faecalis clinical isolates | 2019 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 29, Issue:23 | Synthesis and antibacterial evaluation of novel oxazolidinone derivatives containing a piperidinyl moiety. |
| AID576659 | Bactericidal activity against 2 hrs peripheral compartment culture samples of Enterococcus faecalis ATCC 29212 in two-compartment pharmacokinetic/pharmacodynamic model assessed as effect on bacterial count at 600 mg, bid administered as 0.5 hr infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID115950 | Minimum inhibitory concentration in mice against antimicrobial activity in methicillin-resistant Staphylococcus aureus(MRSA 27660). | 2004 | Bioorganic & medicinal chemistry letters, May-03, Volume: 14, Issue:9 | DNA binding ligands with in vivo efficacy in murine models of bacterial infection: optimization of internal aromatic amino acids. |
| AID390330 | Antimicrobial activity against penicillin-resistant Streptococcus pneumoniae 940 | 2008 | Journal of natural products, Dec, Volume: 71, Issue:12 | Citreamicins with potent gram-positive activity. |
| AID559358 | Antimicrobial activity against compound-resistant Coxiella burnetii Nine-Mile obtained from patient with acute Q fever infected in african green monkey Vero cells after 24 hrs by shell vial assay | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Bacteriostatic and bactericidal activities of tigecycline against Coxiella burnetii and comparison with those of six other antibiotics. |
| AID564132 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus HUSA 304 infected in Wistar rat assessed as decrease in bacterial load in tissue cage fluid at 50 mg/kg, ip administered every 12 hrs for 7 days measured on day 8 post treatment | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | Efficacy of high doses of daptomycin versus alternative therapies against experimental foreign-body infection by methicillin-resistant Staphylococcus aureus. |
| AID576864 | Bactericidal activity against 0.5 hrs peripheral compartment culture samples of Enterococcus faecalis Ef1497 MutM3 in two-compartment pharmacokinetic/pharmacodynamic model assessed as effect on bacterial count at 200 mg, bid administered as 0.5 hr infusio | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID70920 | In vitro antibacterial activity against Escherichia coli ATCC 25922 (Ecol) was determined | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | Structure-activity relationship in the oxazolidinone-quinolone hybrid series: influence of the central spacer on the antibacterial activity and the mode of action. |
| AID1778665 | Ratio of MBC to MIC against methicillin-resistant Staphylococcus aureus ATCC 43300 | 2021 | European journal of medicinal chemistry, Oct-05, Volume: 221 | Design, synthesis and evaluation of novel 9-arylalkyl-10-methylacridinium derivatives as highly potent FtsZ-targeting antibacterial agents. |
| AID260737 | Antibacterial activity against Bacillus subtilis BD54 | 2006 | Journal of medicinal chemistry, Feb-23, Volume: 49, Issue:4 | Hybrid antibacterials. DNA polymerase-topoisomerase inhibitors. |
| AID1271215 | AUC (0 to t) in BALB/c mouse brain at 10 mg/kg, po by LC-MS/MS analysis | 2015 | ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11 | Design, Synthesis, and Identification of Silicon Incorporated Oxazolidinone Antibiotics with Improved Brain Exposure. |
| AID262236 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis ATCC 700802 | 2006 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 16, Issue:6 | Novel 4-N-substituted aryl pent-2-ene-1,4-dione derivatives of piperazinyloxazolidinones as antibacterials. |
| AID388047 | Antibacterial activity against Escherichia coli MB2884 after 18 to 20 hrs by serial dilution method | 2008 | Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19 | Isolation, structure, and antibacterial activity of thiazomycin A, a potent thiazolyl peptide antibiotic from Amycolatopsis fastidiosa. |
| AID560814 | Cmax in human adults with pulmonary tuberculosis at 600 mg administered twice daily for 7 days | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Population pharmacokinetics of linezolid in adults with pulmonary tuberculosis. |
| AID1117370 | Antimicrobial activity against Bacillus subtilis ATCC 6633 assessed as partially clear inhibition zone at 37 degC for 24 hrs by agar diffusion method | 2010 | MedChemComm, Aug-01, Volume: 1, Issue:2 | Syntheses and biological evaluation of new cephalosporin-oxazolidinone conjugates. |
| AID583882 | Antibacterial activity against cfr positive Staphylococcus aureus clinical isolate by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Elevated linezolid resistance in clinical cfr-positive Staphylococcus aureus isolates is associated with co-occurring mutations in ribosomal protein L3. |
| AID245125 | In vitro minimum inhibitory concentration against vancomycin-resistant Enterococcus faecalis NCTC 12201 | 2005 | Bioorganic & medicinal chemistry letters, Jan-17, Volume: 15, Issue:2 | Effects of positional and geometrical isomerism on the biological activity of some novel oxazolidinones. |
| AID283611 | Antimicrobial activity against Enterococcus faecalis 25 with heterozygous 23S rRNA G2576U mutation | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | In vitro activity of the oxazolidinone RWJ-416457 against linezolid-resistant and -susceptible staphylococci and enterococci. |
| AID729221 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae after 16 hrs by NCCLS agar dilution method | 2013 | Journal of medicinal chemistry, Mar-28, Volume: 56, Issue:6 | Solubility-driven optimization of (pyridin-3-yl) benzoxazinyl-oxazolidinones leading to a promising antibacterial agent. |
| AID1079948 | Times to onset, minimal and maximal, observed in the indexed observations. [column 'DELAI' in source] | |||
| AID520234 | Antimicrobial activity against Haemophilus influenzae A1950 | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID576435 | Bactericidal activity against 24 hrs peripheral compartment culture samples of Staphylococcus aureus RN4220 in two-compartment pharmacokinetic/pharmacodynamic model assessed as effect on bacterial count at 600 mg, bid administered as 0.5 hr infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID560517 | Antimicrobial activity against SCCmec type II vancomycin-intermediate Staphylococcus aureus isolate 07b63 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID68251 | In vitro antibacterial activity against vancomycin-resistant Enterococcus faecium UC12712 (VRE); range is 0.5-1 | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | New antibacterial tetrahydro-4(2H)-thiopyran and thiomorpholine S-oxide and S,S-dioxide phenyloxazolidinones. |
| AID1400043 | Bactericidal activity against Staphylococcus aureus BAA 1683 incubated for 24 hrs under aerobic condition by MABA | 2018 | Bioorganic & medicinal chemistry, 09-15, Volume: 26, Issue:17 | An antimycobacterial pleuromutilin analogue effective against dormant bacilli. |
| AID353060 | Antibacterial activity against vancomycin-resistant Enterococcus 3 after 18 to 20 hrs by agar dilution method | 2009 | Bioorganic & medicinal chemistry letters, May-01, Volume: 19, Issue:9 | Synthesis and antibacterial activities of novel oxazolidinones having spiro[2,4]heptane moieties. |
| AID641049 | Antibacterial activity against Streptococcus pneumoniae by agar microdilution method | 2012 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 22, Issue:2 | Design, synthesis, and structure-activity relationship studies of conformationally restricted mutilin 14-carbamates. |
| AID542674 | fCmax in Bacillus anthracis infected in vitro hollow fiber PK/PD model at simulated dose of 300 mg administered every 24 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID1312940 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus USA100 NRS382 clinical isolate after 20 hrs by broth microdilution method | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10 | Second-Generation Phenylthiazole Antibiotics with Enhanced Pharmacokinetic Properties. |
| AID373828 | Antimicrobial activity against panton-valentine leukocidin-negative community-acquired methicillin-resistant Staphylococcus aureus 481 after 50 passages with vancomycin measured after 10 antibiotic-free subculture by multi-step resistance selection techni | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID1374169 | Antibacterial activity against Staphylococcus aureus CMCC 26003 incubated at 37 degC for 20 hrs by agar dilution method | 2018 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4 | Design, synthesis and antibacterial evaluation of honokiol derivatives. |
| AID349313 | Antibacterial activity against Moraxella catarrhalis clinical isolate after 18 hrs by agar dilution method | 2008 | European journal of medicinal chemistry, May, Volume: 43, Issue:5 | Synthesis and structure-antibacterial activity of triazolyl oxazolidinones containing long chain acyl moiety. |
| AID1151629 | Toxicity in female rat assessed as effect on lymphocyte count at 100 mg/kg/day, po bid administered for 4 weeks (Rvb = 74.8%) | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID533948 | Antimicrobial activity against methicillin-resistant, vancomycin intermediate Staphylococcus aureus NRS52 after 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Cellular pharmacodynamics of the novel biaryloxazolidinone radezolid: studies with infected phagocytic and nonphagocytic cells, using Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Legionella pneumophila. |
| AID1243928 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus USA300 assessed as reduction in bacterial growth incubated for 18 to 20 hrs at 37 degC by broth microdilution method | 2015 | European journal of medicinal chemistry, Aug-28, Volume: 101 | Discovery and characterization of aryl isonitriles as a new class of compounds versus methicillin- and vancomycin-resistant Staphylococcus aureus. |
| AID1861522 | Antibacterial activity against Staphylococcus aureus Sta-5027 infected in Swiss mouse model of septicemia administered by oral route 1 h and 5 h post-infection | 2022 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 71 | WCK 4034: A promising oxazolidinone for treating gram positive infections. |
| AID206613 | In vitro antibacterial activity against the methicillin-resistant Staphylococcus aureus 88 | 1999 | Bioorganic & medicinal chemistry letters, Sep-20, Volume: 9, Issue:18 | 3D QSAR studies on new oxazolidinone antibacterial agents by comparative molecular field analysis. |
| AID531643 | Antimicrobial activity against linezolid-resistant Enterococcus faecium A6349 expressing VanA gene | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | R chi-01, a new family of oxazolidinones that overcome ribosome-based linezolid resistance. |
| AID756092 | Antibacterial activity against methicillin-resistant Staphylococcus epidermidis assessed as growth inhibition after 16 hrs by agar dilution method | 2013 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 23, Issue:13 | Synthesis and biological evaluation of novel benzoxazinyl-oxazolidinones as potential antibacterial agents. |
| AID1883847 | Antibacterial activity against Mycobacterium tuberculosis H37Rv assessed as inhibition of bacterial growth incubated for 14 to 21 days | 2022 | Journal of medicinal chemistry, 06-09, Volume: 65, Issue:11 | Tuberculosis Drug Discovery: Challenges and New Horizons. |
| AID297121 | Antibacterial activity against methicillin-resistant Staphylococcus aureus 92-1191 after 18 hrs by agar plate dilution method | 2007 | Journal of medicinal chemistry, Aug-23, Volume: 50, Issue:17 | Discovery of 1,4-dihydroxy-2-naphthoate [corrected] prenyltransferase inhibitors: new drug leads for multidrug-resistant gram-positive pathogens. |
| AID625285 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatic necrosis | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID1778652 | Antibacterial activity against penicillin-resistant Staphylococcus aureus assessed as inhibition of bacterial growth measured by broth microdilution method | 2021 | European journal of medicinal chemistry, Oct-05, Volume: 221 | Design, synthesis and evaluation of novel 9-arylalkyl-10-methylacridinium derivatives as highly potent FtsZ-targeting antibacterial agents. |
| AID533021 | Antibacterial activity against vancomycin-susceptible Staphylococcus aureus N315-LR5-P1-3 assessed as inhibition of bacterial growth in Mueller-Hinton broth medium | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Improved antimicrobial activity of linezolid against vancomycin-intermediate Staphylococcus aureus. |
| AID534154 | Antimicrobial activity against linezolid-resistant Enterococcus faecalis 3124 harboring G2576U mutation in peptidyl transferase centre by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains. |
| AID561250 | Antibacterial activity against Streptococcus pneumoniae assessed as susceptible isolates by CLSI M100-S17 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | AFN-1252, a FabI inhibitor, demonstrates a Staphylococcus-specific spectrum of activity. |
| AID576658 | Bactericidal activity against 1 hr peripheral compartment culture samples of Enterococcus faecalis ATCC 29212 in two-compartment pharmacokinetic/pharmacodynamic model assessed as effect on bacterial count at 600 mg, bid administered as 0.5 hr infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID1059060 | Antibacterial activity against methicillin-resistant Staphylococcus aureus clinical isolate N315 by liquid microdilution method | 2013 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 23, Issue:24 | Structure-anti-MRSA activity relationship of macrocyclic bis(bibenzyl) derivatives. |
| AID1435932 | Bactericidal activity against methicillin/erythromycin/tetracycline-resistant Staphylococcus aureus USA300 NRS384 clinical isolate after 24 hrs | 2017 | European journal of medicinal chemistry, Jan-27, Volume: 126 | Phenylthiazole antibiotics: A metabolism-guided approach to overcome short duration of action. |
| AID285083 | Antimicrobial activity against viridans group Streptococcus constellatus at <= 0.06 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID429428 | Antibacterial activity against Haemophilus influenzae isolate 283 by agar dilution method | 2009 | European journal of medicinal chemistry, Aug, Volume: 44, Issue:8 | Synthesis and antibacterial activity of novel 5-(4-methyl-1H-1,2,3-triazole) methyl oxazolidinones. |
| AID383561 | Antibacterial activity against Enterococcus faecalis ATCC 14506 by broth microdilution technique | 2008 | European journal of medicinal chemistry, Apr, Volume: 43, Issue:4 | Synthesis and in vitro antibacterial activities of novel oxazolidinones. |
| AID68066 | Antibacterial activity against ciprofloxacin resistant and linezolid-resistant Enterococcus faecium (EF4008 LinR;CipR) | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | Novel oxazolidinone-quinolone hybrid antimicrobials. |
| AID559372 | Antimicrobial activity against compound-susceptible Coxiella burnetii isolate CP3 obtained from patient with acute Q fever infected in african green monkey Vero cells after 24 hrs by shell vial assay | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Bacteriostatic and bactericidal activities of tigecycline against Coxiella burnetii and comparison with those of six other antibiotics. |
| AID573140 | Antibacterial activity against erythromycin-nonsusceptible Streptococcus agalactiae assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID1594387 | Tmax in human at 625 mg, iv | 2019 | Bioorganic & medicinal chemistry, 05-01, Volume: 27, Issue:9 | Second-generation aryl isonitrile compounds targeting multidrug-resistant Staphylococcus aureus. |
| AID278860 | Antiproliferative effect against HeLa cells after 48 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Influence on mitochondria and cytotoxicity of different antibiotics administered in high concentrations on primary human osteoblasts and cell lines. |
| AID1677794 | Bacteriostatic activity against penicillin-resistant Staphylococcus aureus assessed as ratio of MBC to MIC | 2020 | Bioorganic & medicinal chemistry, 11-01, Volume: 28, Issue:21 | Design, synthesis of novel 4,5-dihydroisoxazole-containing benzamide derivatives as highly potent FtsZ inhibitors capable of killing a variety of MDR Staphylococcus aureus. |
| AID1327114 | Antibacterial activity against Bacillus subtilis NCIM 2010 at 30 ug/ml measured after 12 hrs by spectrophotometric method | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Design, synthesis and biological evaluation of novel azaspiro analogs of linezolid as antibacterial and antitubercular agents. |
| AID1852666 | Antibacterial activity against multidrug resistant Klebsiella pneumoniae ATCC13883 assessed as inhibition of bacterial growth incubated for 24 hrs in M9-MOPS medium by twofold serial dilution method | |||
| AID283162 | Antimicrobial susceptibility of Staphylococcus lugdunensis IDRL2622 biofilms after 24 hrs assessed as bacterial regrowth | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | In vitro effects of antimicrobial agents on planktonic and biofilm forms of Staphylococcus lugdunensis clinical isolates. |
| AID1180588 | Ratio of MIC for 2 times drug resistance selected Staphylococcus aureus ARC2398-2F to MIC for Staphylococcus aureus ARC2398 | 2014 | Journal of medicinal chemistry, Jul-24, Volume: 57, Issue:14 | Optimization of pyrrolamide topoisomerase II inhibitors toward identification of an antibacterial clinical candidate (AZD5099). |
| AID528848 | Antimicrobial activity against methicillin-resistant Staphylococcus epidermidis assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID1056363 | Antibacterial activity against Staphylococcus aureus Smith clinical isolate assessed as parasite growth inhibition by CLSI broth microdilution method | 2013 | ACS medicinal chemistry letters, Nov-14, Volume: 4, Issue:11 | Potent oxazolidinone antibacterials with heteroaromatic C-ring substructure. |
| AID1710585 | Antibacterial activity against vancomycin-resistant Staphylococcus aureus 12 assessed as inhibition of visible bacterial growth incubated for 18 to 20 hrs by CLSI method | 2020 | RSC medicinal chemistry, Jan-01, Volume: 11, Issue:1 | Potent trifluoromethoxy, trifluoromethylsulfonyl, trifluoromethylthio and pentafluorosulfanyl containing (1,3,4-oxadiazol-2-yl)benzamides against drug-resistant Gram-positive bacteria. |
| AID293553 | Antibacterial activity against Escherichia coli MTCC 51 after 24 hrs by agar dilution assay | 2007 | European journal of medicinal chemistry, Jun, Volume: 42, Issue:6 | Organoiodine(III) mediated synthesis of 3,9-diaryl- and 3,9-difuryl-bis-1,2,4-triazolo[4,3-a][4,3-c]pyrimidines as antibacterial agents. |
| AID1272265 | Antimicrobial activity against vancomycin-susceptible Enterococcus faecalis MMX 101 after 18 to 20 hrs by microdilution method | 2016 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 26, Issue:3 | A stepwise dechlorination/cross-coupling strategy to diversify the vancomycin 'in-chloride'. |
| AID1059059 | Antibacterial activity against 2-phenoxyphenol and trichlosan-resistant Staphylococcus aureus clinical isolate N315 by liquid microdilution method | 2013 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 23, Issue:24 | Structure-anti-MRSA activity relationship of macrocyclic bis(bibenzyl) derivatives. |
| AID444263 | Antibacterial activity against vancomycin-resistant Enterococcus faecium 6A by NCCLS method | 2009 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 19, Issue:22 | Synthesis and biological activity of novel oxazolidinones. |
| AID207721 | In vitro minimum inhibitory concentration (MIC) against Staphylococcus aureus UC9213 | 2003 | Journal of medicinal chemistry, Jan-16, Volume: 46, Issue:2 | Identification of phenylisoxazolines as novel and viable antibacterial agents active against Gram-positive pathogens. |
| AID373660 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus 543 by agar dilution CLSI method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID1474206 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis clinical isolates after 18 to 22 hrs by broth microdilution method | 2017 | Journal of medicinal chemistry, 03-23, Volume: 60, Issue:6 | Phenylthiazole Antibacterial Agents Targeting Cell Wall Synthesis Exhibit Potent Activity in Vitro and in Vivo against Vancomycin-Resistant Enterococci. |
| AID349312 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after 18 hrs by agar dilution method | 2008 | European journal of medicinal chemistry, May, Volume: 43, Issue:5 | Synthesis and structure-antibacterial activity of triazolyl oxazolidinones containing long chain acyl moiety. |
| AID577134 | AUC in two-compartment pharmacokinetic/pharmacodynamic model at 600 mg, bid administered as 0.5 hr infusion over 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID284966 | Antimicrobial activity against Corynebacterium jeikeium at <= 0.06 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID410109 | Antimicrobial activity against Linezolid-resistant Enterococcus faecalis ATCC 29212-P5 by NCCLS method | 2008 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 18, Issue:23 | Design at the atomic level: design of biaryloxazolidinones as potent orally active antibiotics. |
| AID520029 | Antimicrobial activity against Enterococcus faecium A6348 harboring G2576U mutation in 23S rRNA | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID499111 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus Smith OC 4172 infected immunocompromized SKH1 mouse assessed as lesion volume at 6.2 mg/kg/day, sc measured after 48 hrs postinfection (Rvb = 1181 mm3) | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vivo activity of ceftobiprole in murine skin infections due to Staphylococcus aureus and Pseudomonas aeruginosa. |
| AID520235 | Antimicrobial activity against Staphylococcus aureus A7820 | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID533003 | Antibacterial activity against vancomycin-intermediate Staphylococcus aureus PC phenotypic revertant after 24 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Improved antimicrobial activity of linezolid against vancomycin-intermediate Staphylococcus aureus. |
| AID1151753 | Antibacterial activity against penicillin intermediate-sensitive Streptococcus pneumoniae ATCC 49619 clinical isolate | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID1721016 | Inhibition of mitochondrial protein synthesis in rat H9c2 cells measured after 5 days by ELISA | 2020 | Journal of medicinal chemistry, 09-10, Volume: 63, Issue:17 | Discovery of a Conformationally Constrained Oxazolidinone with Improved Safety and Efficacy Profiles for the Treatment of Multidrug-Resistant Tuberculosis. |
| AID542887 | fT>MIC in Bacillus anthracis infected in vitro hollow fiber PK/PD model at simulated dose of 800 mg administered as 2 divided doses every 12 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID542692 | fT>MIC in Bacillus anthracis infected in vitro hollow fiber PK/PD model at simulated dose of 500 mg administered every 24 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID311477 | Antimicrobial activity against Staphylococcus epidermidis ATCC 700578 after 14 to 16 hrs by serial micro-broth dilution method | 2007 | Journal of natural products, Sep, Volume: 70, Issue:9 | Lipoxazolidinones A, B, and C: antibacterial 4-oxazolidinones from a marine actinomycete isolated from a Guam marine sediment. |
| AID576398 | Tmax in two-compartment pharmacokinetic/pharmacodynamic model at 800 mg, bid administered as 0.5 hrs infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID575145 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus isolate NRS71 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Inhibition of antibiotic-resistant Staphylococcus aureus by the broad-spectrum dihydrofolate reductase inhibitor RAB1. |
| AID285011 | Antimicrobial activity against Enterococcus hirae at 1 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID558721 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus 525 measured on day 45 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID1721019 | Antitubercular activity against Mycobacterium tuberculosis isolate 12525 incubated for 7 days by microplate alamar blue assay | 2020 | Journal of medicinal chemistry, 09-10, Volume: 63, Issue:17 | Discovery of a Conformationally Constrained Oxazolidinone with Improved Safety and Efficacy Profiles for the Treatment of Multidrug-Resistant Tuberculosis. |
| AID284942 | Antimicrobial activity against Aerococcus spp. at 0.5 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID405627 | Toxicity in rat heart mitochondria assessed as inhibition of mitochondrial protein synthesis | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Comparative study of the effects of pyridoxine, rifampin, and renal function on hematological adverse events induced by linezolid. |
| AID68064 | Antibacterial activity against ciprofloxacin resistant Enterococcus faecium (EF4010 CipR) | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | Novel oxazolidinone-quinolone hybrid antimicrobials. |
| AID531637 | Inhibition of 50S ribosomal subunit purified from linezolid-,erythromycin-resistant Staphylococcus aureus A7820 with G2576U mutation in 23s rRNA assessed as inhibition of translation using in vitro transcribed mRNA encoding firefly luciferase | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | R chi-01, a new family of oxazolidinones that overcome ribosome-based linezolid resistance. |
| AID584996 | Antibacterial activity against methicillin-resistant Staphylococcus aureus M05/0060 harboring cfr-encoding conjugative pSCFS7 and fexA by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Identification and characterization of the multidrug resistance gene cfr in a Panton-Valentine leukocidin-positive sequence type 8 methicillin-resistant Staphylococcus aureus IVa (USA300) isolate. |
| AID1308228 | Antibacterial activity against vancomycin/methicillin-resistant Staphylococcus aureus VRS2 clinical isolate incubated for 16 to 20 hrs by microdilution method | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10 | Structure-Activity Relationship for the 4(3H)-Quinazolinone Antibacterials. |
| AID134114 | Protective dose of orally administered compound against intraperitoneally-induced septicaemia model (Enterococci faecalis D2HT6 strain) in murine | 2000 | Bioorganic & medicinal chemistry letters, Aug-07, Volume: 10, Issue:15 | Improved antibacterial activities of coumarin antibiotics bearing 5',5'-dialkylnoviose: biological activity of RU79115. |
| AID442575 | Antibacterial activity against Bacillus cereus MTCC 430 after 24 hrs by spectrophotometry | 2010 | European journal of medicinal chemistry, Feb, Volume: 45, Issue:2 | Synthesis of nitroimidazole derived oxazolidinones as antibacterial agents. |
| AID1126490 | Antimicrobial activity against erythromycin-susceptible Streptococcus pneumoniae ATCC 49619 | 2014 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 24, Issue:8 | Synthesis, antibiotic activity and structure-activity relationship study of some 3-enaminetetramic acids. |
| AID245299 | Minimal inhibitory concentration against methicillin resistant Staphylococcus epidermidis ATCC 23760 | 2004 | Bioorganic & medicinal chemistry letters, Sep-20, Volume: 14, Issue:18 | Synthesis and antibacterial activity of some aryloxy/thioaryloxy oxazolidinone derivatives. |
| AID630557 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae after 16 hrs by agar dilution method | 2011 | Journal of medicinal chemistry, Nov-10, Volume: 54, Issue:21 | Design, synthesis, and structure-activity relationship studies of highly potent novel benzoxazinyl-oxazolidinone antibacterial agents. |
| AID1723500 | Antibacterial activity against Enterococcus faecalis HM-334 incubated for 18 to 20 hrs under aerobic condition by CLSI protocol based broth microdilution assay | |||
| AID244924 | Antibacterial activity against Streptococcus mitis IID685 was determined | 2004 | Bioorganic & medicinal chemistry letters, Oct-18, Volume: 14, Issue:20 | Synthesis and antibacterial activity of novel 6-fluoro-1-[(1R,2S)-2-fluorocyclopropan-1-yl]-4-oxoquinoline-3-carboxylic acids bearing cyclopropane-fused 2-amino-8-azabicyclo[4.3.0]nonan-8-yl substituents at the C-7 position. |
| AID541079 | Cmin in cage fluid of Albino guiena pig at 25 mg/kg, ip after 12 hrs | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Linezolid alone or combined with rifampin against methicillin-resistant Staphylococcus aureus in experimental foreign-body infection. |
| AID560510 | Antimicrobial activity against SCCmec type III vancomycin-intermediate Staphylococcus aureus isolate b5k3529 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID396029 | Antibacterial activity against drug-resistant AcrAB-TolC efflux pump deficient Enterobacter cloacae EcdeltaacrA isolate in presence of 20 ug/ml efflux pump inhibitor Phe-Arg-beta-naphthylamide by Etest | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Cloning, nucleotide sequencing, and analysis of the AcrAB-TolC efflux pump of Enterobacter cloacae and determination of its involvement in antibiotic resistance in a clinical isolate. |
| AID1584841 | Antibacterial activity against methicillin and linezolid resistant Staphylococcus aureus NRS 119 clinical isolate after 18 to 24 hrs by microdilution assay | 2018 | European journal of medicinal chemistry, Nov-05, Volume: 159 | 1-(2-Hydroxybenzoyl)-thiosemicarbazides are promising antimicrobial agents targeting d-alanine-d-alanine ligase in bacterio. |
| AID576408 | AUC in two-compartment pharmacokinetic/pharmacodynamic model at 200 mg, bid administered as 0.5 hrs infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID1861521 | Antibacterial activity against Haemophilus influenzae pneumoniae ATCC 35054 incubated for 18 hrs by CLSI protocol based two-fold serial agar dilution method | 2022 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 71 | WCK 4034: A promising oxazolidinone for treating gram positive infections. |
| AID533634 | Antimicrobial activity against Propionibacterium acnes assessed as resistant isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activities of doripenem, a new broad-spectrum carbapenem, against recently collected clinical anaerobic isolates, with emphasis on the Bacteroides fragilis group. |
| AID201408 | Inhibitory activity against Methicillin-resistant Staphylococcus aureus UC6685 | 2000 | Journal of medicinal chemistry, Mar-09, Volume: 43, Issue:5 | Substituent effects on the antibacterial activity of nitrogen-carbon-linked (azolylphenyl)oxazolidinones with expanded activity against the fastidious gram-negative organisms Haemophilus influenzae and Moraxella catarrhalis. |
| AID533023 | Antibacterial activity against vancomycin-susceptible Staphylococcus aureus N315-LR5-P1-4 assessed as inhibition of bacterial growth in Mueller-Hinton broth medium | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Improved antimicrobial activity of linezolid against vancomycin-intermediate Staphylococcus aureus. |
| AID562195 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus 543 measured after 10 antibiotic-free subculturing by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID575147 | Antimicrobial activity against vancomycin-resistant Staphylococcus aureus VRS1 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Inhibition of antibiotic-resistant Staphylococcus aureus by the broad-spectrum dihydrofolate reductase inhibitor RAB1. |
| AID520771 | Toxicity in methicillin-resistant Staphylococcus aureus-infected New Zealand rabbit osteomyelitis model assessed as body weight at 60 mg/kg, po administered every 8 hrs for 4 days measured on week 2 postinfection (Rvb = 2.43 +/- 0.15 kg) | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Efficacies of ceftobiprole medocaril and comparators in a rabbit model of osteomyelitis due to methicillin-resistant Staphylococcus aureus. |
| AID1519260 | Metabolic stability in human liver microsomes assessed as parent compound remaining after 45 mins in presence of NADPH relative to control | 2019 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 29, Issue:23 | Synthesis and antibacterial evaluation of novel oxazolidinone derivatives containing a piperidinyl moiety. |
| AID345134 | Inhibition of protein synthesis in Escherichia coli S30 extract by translation assay | 2008 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 18, Issue:23 | Design at the atomic level: generation of novel hybrid biaryloxazolidinones as promising new antibiotics. |
| AID1304833 | Antibacterial activity against Staphylococcus epidermidis ATCC 12228 incubated for 16 to 18 hrs by broth microdilution method | 2016 | Journal of medicinal chemistry, 04-28, Volume: 59, Issue:8 | Structure-Activity Relationships of a Diverse Class of Halogenated Phenazines That Targets Persistent, Antibiotic-Tolerant Bacterial Biofilms and Mycobacterium tuberculosis. |
| AID520010 | Antimicrobial activity against Staphylococcus aureus A8833 harboring U2500A mutation in 23S rRNA | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID585163 | Antibacterial activity against Mycobacterium smegmatis harboring 23S rRNA C2571G mutant after 24 generation times | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Mutations in 23S rRNA at the peptidyl transferase center and their relationship to linezolid binding and cross-resistance. |
| AID409583 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus 05-2 infected in po dosed KunMing SPF mouse | 2008 | European journal of medicinal chemistry, Aug, Volume: 43, Issue:8 | Synthesis and biological evaluation of new N-linked 5-triazolylmethyl oxazolidinones. |
| AID562175 | Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus 1287 after 50 passages by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID1501368 | Bactericidal activity against vancomycin-resistant Staphylococcus aureus isolate 4 incubated for 20 hrs followed by replating on tryptic soy agar plates and further incubated for 18 hrs by broth microdilution assay | 2017 | European journal of medicinal chemistry, Oct-20, Volume: 139 | Arylthiazole antibiotics targeting intracellular methicillin-resistant Staphylococcus aureus (MRSA) that interfere with bacterial cell wall synthesis. |
| AID517670 | Antimicrobial activity against Enterococcus faecium NCTC 12203 by standard serial-dilution technique | 2010 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 20, Issue:20 | Bottromycin derivatives: efficient chemical modifications of the ester moiety and evaluation of anti-MRSA and anti-VRE activities. |
| AID1400019 | Antibacterial activity against Staphylococcus aureus incubated for 24 hrs under aerobic condition by MABA | 2018 | Bioorganic & medicinal chemistry, 09-15, Volume: 26, Issue:17 | An antimycobacterial pleuromutilin analogue effective against dormant bacilli. |
| AID205585 | Compound was evaluated for minimum inhibitory concentration against Staphylococcus epidermidis 9753 strain | 2002 | Bioorganic & medicinal chemistry letters, Mar-25, Volume: 12, Issue:6 | Synthesis and antibacterial activity of linezolid analogues. |
| AID424423 | Antibacterial activity against Enterococcus faecalis HIP15179 coisolated with vancomycin-resistant Staphylococcus aureus by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Vancomycin-resistant Staphylococcus aureus isolates associated with Inc18-like vanA plasmids in Michigan. |
| AID1312943 | Antimicrobial activity against vancomycin-resistant Staphylococcus aureus 10 clinical isolate after 20 hrs by broth microdilution method | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10 | Second-Generation Phenylthiazole Antibiotics with Enhanced Pharmacokinetic Properties. |
| AID1519043 | Antibacterial activity against clinical isolates of vancomycin-resistant Enterococcus faecium assessed as complete reduction in bacterial cell growth by CLSI protocol based broth liquid microdilution method | 2020 | European journal of medicinal chemistry, Jan-01, Volume: 185 | Optimization of biaryloxazolidinone as promising antibacterial agents against antibiotic-susceptible and antibiotic-resistant gram-positive bacteria. |
| AID565076 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus ATCC 29213 by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Pharmacodynamic profile of tigecycline against methicillin-resistant Staphylococcus aureus in an experimental pneumonia model. |
| AID410103 | Inhibition of Escherichia coli translation | 2008 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 18, Issue:23 | Design at the atomic level: design of biaryloxazolidinones as potent orally active antibiotics. |
| AID542915 | Antimicrobial activity against Bacillus anthracis infected in in vitro hollow fiber PK/PD model assessed as reduction in bacterial burden at 700 mg administered once every 24 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID530123 | Antimicrobial activity against hospital acquired methicillin-resistant Staphylococcus aureus 56 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Pharmacodynamic characterization of ceftobiprole in experimental pneumonia caused by phenotypically diverse Staphylococcus aureus strains. |
| AID528978 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID484701 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus | 2010 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 20, Issue:12 | Potent antimicrobial activity of 3-(4,5-diaryl-1H-imidazol-2-yl)-1H-indole derivatives against methicillin-resistant Staphylococcus aureus. |
| AID458456 | Antimicrobial activity against wild type Pseudomonas aeruginosa K799 at 2 mM after overnight incubation by agar diffusion method | 2010 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 20, Issue:3 | Syntheses and antibacterial activity studies of new oxazolidinones from nitroso Diels-Alder chemistry. |
| AID523815 | Antimicrobial activity against oxacillin-susceptible coagulase-negative Staphylococcus aureus assessed as inhibition of microbial growth at 0.5 ug/ml by CLSI method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Comparative activities of TR-700 (torezolid) against staphylococcal blood isolates collected in Spain. |
| AID1076823 | Antitubercular activity against multidrug-resistant Mycobacterium tuberculosis clinical isolate 2 assessed as growth inhibition by microdilution method | 2014 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 24, Issue:6 | Discovery of novel bis-oxazolidinone compounds as potential potent and selective antitubercular agents. |
| AID352928 | Antibacterial activity against Haemophilus influenzae after 18 to 20 hrs by agar dilution method | 2009 | Bioorganic & medicinal chemistry letters, May-01, Volume: 19, Issue:9 | Synthesis and antibacterial activities of novel oxazolidinones having spiro[2,4]heptane moieties. |
| AID528710 | Antibacterial activity against penicillin intermediate Streptococcus pneumoniae clinical isolate assessed as susceptibility level by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID558500 | Antimicrobial activity against heterogeneous vancomycin-intermediate Staphylococcus aureus 873 measured on day 20 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID1898414 | Bactericidal activity against methicillin-resistant vancomycin-resistant Enterococcus faecium ATCC 700221 planktonic cells assessed as planktonic eradication incubated for 24 hrs followed by incubation for overnight in fresh medium by Calgary biofilm devi | 2021 | Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11 | A Modular Synthetic Route Involving |
| AID293839 | Antibacterial activity against Enterococcus faecium ATCC 19434 | 2007 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6 | A new class of anti-MRSA and anti-VRE agents: preparation and antibacterial activities of indole-containing compounds. |
| AID548253 | Antibacterial activity against vancomycin-intermediate Staphylococcus aureus Mu50 after 24 hrs by Etest | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Contribution of vraSR and graSR point mutations to vancomycin resistance in vancomycin-intermediate Staphylococcus aureus. |
| AID1079933 | Acute liver toxicity defined via clinical observations and clear clinical-chemistry results: serum ALT or AST activity > 6 N or serum alkaline phosphatases activity > 1.7 N. This category includes cytolytic, choleostatic and mixed liver toxicity. Value is | |||
| AID567456 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus CGK8 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Development of daptomycin nonsusceptibility with heterogeneous vancomycin-intermediate resistance and oxacillin susceptibility in methicillin-resistant Staphylococcus aureus during high-dose daptomycin treatment. |
| AID368290 | Bactericidal activity against methicillin-resistant Staphylococcus aureus SA2 in rabbit endocarditis model assessed as growth inhibition at 58 mg/kg infused every 12 hrs for 4 days measured after 48 hrs | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vivo efficacy of ceftaroline (PPI-0903), a new broad-spectrum cephalosporin, compared with linezolid and vancomycin against methicillin-resistant and vancomycin-intermediate Staphylococcus aureus in a rabbit endocarditis model. |
| AID410221 | Antibacterial activity against Escherichia coli LCB0012 by broth micro dilution method | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24 | A facile synthesis, antibacterial, and antitubercular studies of some piperidin-4-one and tetrahydropyridine derivatives. |
| AID1151707 | Antibacterial activity against Staphylococcus aureus in po dosed mouse septicemia model | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID1493806 | Antibacterial activity against Staphylococcus aureus VRS11a clinical isolate after 20 hrs by broth microdilution method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Biphenylthiazole antibiotics with an oxadiazole linker: An approach to improve physicochemical properties and oral bioavailability. |
| AID1778658 | Bactericidal activity against erythromycin-susceptible Staphylococcus aureus ATCC 25923 measured after 24 hrs by CLSI protocol based method | 2021 | European journal of medicinal chemistry, Oct-05, Volume: 221 | Design, synthesis and evaluation of novel 9-arylalkyl-10-methylacridinium derivatives as highly potent FtsZ-targeting antibacterial agents. |
| AID308725 | Inhibition of transcription and translation activity in Escherichia coli by luciferase reporter assay | 2007 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 17, Issue:16 | Synthesis and SAR of novel conformationally-restricted oxazolidinones possessing gram-positive and fastidious gram-negative antibacterial activity. Part 1: Substituted pyrazoles. |
| AID1400760 | Bactericidal activity against vancomycin-resistant Enterococcus faecium ATCC 700221 after 24 hrs by calgary biofilm device-based assay | 2017 | MedChemComm, Apr-01, Volume: 8, Issue:4 | Microwave-enhanced Friedländer synthesis for the rapid assembly of halogenated quinolines with antibacterial and biofilm eradication activities against drug resistant and tolerant bacteria. |
| AID207882 | Antibacterial activity against Methicillin-resistant Staphylococcus epidermidis UC12084 (S. e) | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | Synthesis and biological evaluation of benzazepine oxazolidinone antibacterials. |
| AID68249 | In vitro antibacterial activity against vancomycin-resistant Enterococcus faecium 154 (Enterococcus faecium ATCC 12202) | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | Influence of ethylene-oxy spacer group on the activity of linezolid: synthesis of potent antibacterials possessing a thiocarbonyl group. |
| AID575051 | Cmin in patient plasma at 600 mg, iv or 600 mg, po administered every 12 hrs co-treated with rifampin by HPLC | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Therapeutic drug monitoring of linezolid: a retrospective monocentric analysis. |
| AID559795 | Antimicrobial activity against heterogeneous vancomycin-intermediate Staphylococcus aureus assessed as growth inhibition at 4 times MIC | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID1770370 | Ratio of MBC to MIC against Vancomycin-resistant Enterococcus faecium ATCC 51559 | 2021 | European journal of medicinal chemistry, Nov-15, Volume: 224 | Modification of 5-methylphenanthridium from benzothiazoles to indoles as potent FtsZ inhibitors: Broadening the antibacterial spectrum toward vancomycin-resistant enterococci. |
| AID1778645 | Antibacterial activity against erythromycin-susceptible Staphylococcus aureus ATCC 25923 assessed as bacterial growth inhibition incubated for 24 hrs by CLSI protocol based broth microdilution method | 2021 | European journal of medicinal chemistry, Oct-05, Volume: 221 | Design, synthesis and evaluation of novel 9-arylalkyl-10-methylacridinium derivatives as highly potent FtsZ-targeting antibacterial agents. |
| AID297124 | Antibacterial activity against Staphylococcus aureus macrolide-resistance after 18 hrs by agar plate dilution method | 2007 | Journal of medicinal chemistry, Aug-23, Volume: 50, Issue:17 | Discovery of 1,4-dihydroxy-2-naphthoate [corrected] prenyltransferase inhibitors: new drug leads for multidrug-resistant gram-positive pathogens. |
| AID1197119 | Antibacterial activity against vancomycin/methicillin-resistant Staphylococcus aureus VRS1 clinical isolate after 16 to 20 hrs by broth microdilution method | 2015 | Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3 | Structure-activity relationship for the oxadiazole class of antibiotics. |
| AID284950 | Antimicrobial activity against Bacillus spp. at 2 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID1400061 | Antibacterial activity against Bacillus subtilis ATCC 6051 incubated for 24 hrs under aerobic condition by MABA | 2018 | Bioorganic & medicinal chemistry, 09-15, Volume: 26, Issue:17 | An antimycobacterial pleuromutilin analogue effective against dormant bacilli. |
| AID368289 | Bactericidal activity against vancomycin-intermediate Staphylococcus aureus in rabbit endocarditis model assessed per gram of aortic vegetation at 58 mg/kg infused every 12 hrs for 4 days measured after 48 hrs | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vivo efficacy of ceftaroline (PPI-0903), a new broad-spectrum cephalosporin, compared with linezolid and vancomycin against methicillin-resistant and vancomycin-intermediate Staphylococcus aureus in a rabbit endocarditis model. |
| AID1151625 | Toxicity in female rat assessed as effect on mean corpuscular volume at 100 mg/kg/day, po bid administered for 4 weeks (Rvb = 53.72 fL) | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID1473739 | Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and GSH measured after 20 mins by membrane vesicle transport assay | 2013 | Toxicological sciences : an official journal of the Society of Toxicology, Nov, Volume: 136, Issue:1 | A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. |
| AID1519039 | Antibacterial activity against vancomycin-resistant Enterococcus faecium assessed as complete reduction in bacterial cell growth by CLSI protocol based broth liquid microdilution method | 2020 | European journal of medicinal chemistry, Jan-01, Volume: 185 | Optimization of biaryloxazolidinone as promising antibacterial agents against antibiotic-susceptible and antibiotic-resistant gram-positive bacteria. |
| AID1400023 | Antibacterial activity against replicating Mycobacterium tuberculosis H37Rv incubated for 15 days under aerobic condition by MABA | 2018 | Bioorganic & medicinal chemistry, 09-15, Volume: 26, Issue:17 | An antimycobacterial pleuromutilin analogue effective against dormant bacilli. |
| AID1504623 | Antibacterial activity against Streptococcus pneumoniae 55143 by microbroth dilution method | 2017 | ACS medicinal chemistry letters, Nov-09, Volume: 8, Issue:11 | Design, Synthesis, and Antibacterial Evaluation of Oxazolidinones with Fused Heterocyclic C-Ring Substructure. |
| AID284985 | Antimicrobial activity against Enterococcus avium at 2 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID70918 | In vitro antibacterial activity against Escherichia coli AS19 (Eco2), permeable mutant was determined | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | Structure-activity relationship in the oxazolidinone-quinolone hybrid series: influence of the central spacer on the antibacterial activity and the mode of action. |
| AID1304847 | Antibacterial activity against methicillin-resistant Staphylococcus aureus clinical isolate 2 incubated for 16 hrs by broth microdilution method in presence of tiron | 2016 | Journal of medicinal chemistry, 04-28, Volume: 59, Issue:8 | Structure-Activity Relationships of a Diverse Class of Halogenated Phenazines That Targets Persistent, Antibiotic-Tolerant Bacterial Biofilms and Mycobacterium tuberculosis. |
| AID1154473 | Antibacterial activity against clinical isolate of methicillin-sensitive Staphylococcus aureus infected in iv dosed mouse assessed as host survival administered 1 hr after infection for 4 days | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | Design, synthesis, and structure-activity relationship studies of novel thioether pleuromutilin derivatives as potent antibacterial agents. |
| AID533980 | Antimicrobial activity against linezolid-resistant Staphylococcus aureus SA040L infected in THP1 cells after 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Cellular pharmacodynamics of the novel biaryloxazolidinone radezolid: studies with infected phagocytic and nonphagocytic cells, using Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Legionella pneumophila. |
| AID345137 | Antimicrobial activity against linezolid-resistant Enterococcus faecalis P5 by NCCLS method | 2008 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 18, Issue:23 | Design at the atomic level: generation of novel hybrid biaryloxazolidinones as promising new antibiotics. |
| AID542673 | fCmax in Bacillus anthracis infected in vitro hollow fiber PK/PD model at simulated dose of 200 mg administered every 24 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID1329448 | Antibacterial activity against linezolid-resistant Mycobacterium tuberculosis H37Rv in hollow-fiber infection model assessed as reduction in bacterial burden at 342 mg, po at 24 hrs dose regimen measured after 3 weeks | 2016 | Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24 | From lead optimization to NDA approval for a new antimicrobial: Use of pre-clinical effect models and pharmacokinetic/pharmacodynamic mathematical modeling. |
| AID374015 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus 481 after single-step resistance selection by agar dilution CLSI method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID285024 | Antimicrobial activity against Listeria monocytogenes at 2 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID1432970 | Antitubercular activity against Mycobacterium tuberculosis H37Rv after 7 days by microplate alamar blue assay | |||
| AID1680044 | Antibacterial activity against NDM1 producing carbapenem-resistant Enterobacteriaceae clinical isolate 2 assessed as reduction in bacterial growth incubated for 16 to 20 hrs by CLSI-based broth microdilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | Synthesis and antibacterial bioactivities of cationic deacetyl linezolid amphiphiles. |
| AID637974 | Antibacterial activity against Enterococcus faecalis ATCC 29212 expressing VanS gene after overnight incubation by twofold broth dilution technique | 2012 | Bioorganic & medicinal chemistry, Jan-01, Volume: 20, Issue:1 | Efficient microwave-assisted synthesis, antibacterial activity and high fluorescence of 5 benzimidazolyl-2'-deoxyuridines. |
| AID533973 | Antimicrobial activity against linezolid-resistant Staphylococcus aureus SA040L infected in THP1 cells assessed as log reduction in bacterial count after 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Cellular pharmacodynamics of the novel biaryloxazolidinone radezolid: studies with infected phagocytic and nonphagocytic cells, using Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Legionella pneumophila. |
| AID625287 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatomegaly | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID383737 | Tmax in Sprague-Dawley rat at 25 mg/kg, po | 2008 | European journal of medicinal chemistry, Apr, Volume: 43, Issue:4 | Synthesis and in vitro antibacterial activities of novel oxazolidinones. |
| AID1167989 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis clinical isolate 5814 after overnight incubation by two-fold serial dilution method | 2014 | Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21 | Synthesis and biological evaluation of novel peptide BF2 as an antibacterial agent against clinical isolates of vancomycin-resistant enterococci. |
| AID533015 | Antibacterial activity against vancomycin-susceptible Staphylococcus aureus N315-LR5-P1 assessed as inhibition of bacterial growth in Mueller-Hinton broth medium | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Improved antimicrobial activity of linezolid against vancomycin-intermediate Staphylococcus aureus. |
| AID574076 | Apparent oral clearance in CF-1 mouse at 10 mg/kg, sc | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | In vivo activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. |
| AID1873905 | Antibacterial activity against Staphylococcus aureus incubated for 16 to 20 hrs by broth microdilution method | 2022 | European journal of medicinal chemistry, Aug-05, Volume: 238 | Design, synthesis and activity against drug-resistant bacteria evaluation of C-20, C-23 modified 5-O-mycaminosyltylonolide derivatives. |
| AID1390467 | Antibacterial activity against methicillin-resistant Staphylococcus aureus USA300 BAA-1556 | 2018 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 28, Issue:7 | Design, synthesis and biological evaluation of spiropyrimidinetriones oxazolidinone derivatives as antibacterial agents. |
| AID292908 | Antibacterial activity against Streptococcus pneumoniae ARC548 infected C57BL/6 mouse lung at 25 mg/kg, po after 2 days relative to Linezolid | 2007 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 17, Issue:2 | New carbon-linked azole oxazolidinones with improved potency and pharmacokinetics. |
| AID1393956 | Antibacterial activity against methicillin resistant Staphylococcus aureus NR 45913 after 16 to 20 hrs by CLSI method | 2018 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 28, Issue:16 | 3-Hydroxy-1,5-dihydro-2H-pyrrol-2-ones as novel antibacterial scaffolds against methicillin-resistant Staphylococcus aureus. |
| AID1415066 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus isolate 2 after 16 hrs by agar dilution method | 2018 | Journal of medicinal chemistry, 12-27, Volume: 61, Issue:24 | Semisynthesis of Platensimycin Derivatives with Antibiotic Activities in Mice via Suzuki-Miyaura Cross-Coupling Reactions. |
| AID1233136 | Antibacterial activity against patient-derived methicillin-resistant Staphylococcus aureus B19506 after 18 to 20 hrs by microbroth dilution method | 2015 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 25, Issue:13 | Thiol activated prodrugs of sulfur dioxide (SO2) as MRSA inhibitors. |
| AID285062 | Antimicrobial activity against beta hemolytic Streptococci group F at 0.5 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID576423 | Antibacterial activity against Enterococcus faecalis Ef1497 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID1056349 | Inhibition of rat forebrain MAO-B using [14C]PEA as substrate at 30 uM preincubated for 20 mins followed by substrate addition measured after 10 mins by liquid scintillation counting analysis | 2013 | ACS medicinal chemistry letters, Nov-14, Volume: 4, Issue:11 | Potent oxazolidinone antibacterials with heteroaromatic C-ring substructure. |
| AID132588 | In vivo Efficacy of compound after peroral administration to protect the Staphylococcus aureus mouse septicemia model | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | New antibacterial tetrahydro-4(2H)-thiopyran and thiomorpholine S-oxide and S,S-dioxide phenyloxazolidinones. |
| AID1603310 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus ATCC 33591 measured after 16 hrs by broth microdilution method | 2019 | ACS medicinal chemistry letters, Mar-14, Volume: 10, Issue:3 | Expanded Structure-Activity Studies of Lipoxazolidinone Antibiotics. |
| AID565489 | Ratio of MBC to MIC for methicillin-susceptible Staphylococcus aureus | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro bactericidal activity of iclaprim in human plasma. |
| AID576868 | Bactericidal activity against 12.5 hrs peripheral compartment culture samples of Enterococcus faecalis Ef1497 MutM3 in two-compartment pharmacokinetic/pharmacodynamic model assessed as effect on bacterial count at 200 mg, bid administered as 0.5 hr infusi | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID1400049 | Bactericidal activity against Enterococcus faecalis ATCC 19433 incubated for 24 hrs under aerobic condition by MABA | 2018 | Bioorganic & medicinal chemistry, 09-15, Volume: 26, Issue:17 | An antimycobacterial pleuromutilin analogue effective against dormant bacilli. |
| AID208011 | The compound was evaluated for its anti-bacterial activity against Streptococcus pneumoniae UC 9912 | 1998 | Journal of medicinal chemistry, Dec-17, Volume: 41, Issue:26 | Nitrogen-carbon-linked (azolylphenyl)oxazolidinones with potent antibacterial activity against the fastidious gram-negative organisms Haemophilus influenzae and Moraxella catarrhalis. |
| AID289868 | Antibacterial activity against Enterococcus faecium ATCC 12202 | 2007 | European journal of medicinal chemistry, Apr, Volume: 42, Issue:4 | Synthesis, SAR and antibacterial studies on novel chalcone oxazolidinone hybrids. |
| AID67754 | Minimum inhibitory concentration against Enterococcus faecalis MTCC 439 | 2004 | Bioorganic & medicinal chemistry letters, Jun-21, Volume: 14, Issue:12 | Oxazolidinone: search for highly potent antibacterial. |
| AID1692906 | Antibacterial activity against hospital acquired vancomycin-resistant Enterococcus faecium clinical isolates | 2021 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 32 | Design, synthesis and antibacterial evaluation of novel oxazolidinone derivatives nitrogen-containing fused heterocyclic moiety. |
| AID1760589 | Antibacterial activity against wild type Escherichia coli JW5503 delta tolC assessed as inhibition of bacterial growth measured after 24 hrs | 2021 | European journal of medicinal chemistry, Feb-05, Volume: 211 | Installation of an aryl boronic acid function into the external section of N-aryl-oxazolidinones: Synthesis and antimicrobial evaluation. |
| AID1574849 | Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay | 2019 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 29, Issue:3 | Design and synthesis of biaryloxazolidinone derivatives containing a rhodanine or thiohydantoin moiety as novel antibacterial agents against Gram-positive bacteria. |
| AID1591547 | Ratio of MBC for methicillin-resistant Staphylococcus aureus ATCC 43300 to MIC for methicillin-resistant Staphylococcus aureus ATCC 43300 | 2019 | Bioorganic & medicinal chemistry, 07-15, Volume: 27, Issue:14 | Discovery of 1,3,4-oxadiazol-2-one-containing benzamide derivatives targeting FtsZ as highly potent agents of killing a variety of MDR bacteria strains. |
| AID285549 | Tmax in mouse at 20 mg/kg, sc | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | In vitro and in vivo antibacterial activities of heteroaryl isothiazolones against resistant gram-positive pathogens. |
| AID1519261 | Cytotoxicity against human HepG2 cells assessed as reduction in cell viability | 2019 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 29, Issue:23 | Synthesis and antibacterial evaluation of novel oxazolidinone derivatives containing a piperidinyl moiety. |
| AID285092 | Antimicrobial activity against viridans group Streptococcus gordonii at 0.5 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID439892 | Antibacterial activity against Pseudomonas aeruginosa ATCC 90277 after 18 hrs by agar dilution method | 2010 | European journal of medicinal chemistry, Jan, Volume: 45, Issue:1 | Synthesis and antibacterial activity of isothiazolyl oxazolidinones and analogous 3(2H)-isothiazolones. |
| AID66111 | In vitro antibacterial activity against Enterococcus faecalis ATCC 29212 (E. f. 034) vancomycin sensitive | 2002 | Journal of medicinal chemistry, Aug-29, Volume: 45, Issue:18 | Synthesis of conformationally constrained analogues of linezolid: structure-activity relationship (SAR) studies on selected novel tricyclic oxazolidinones. |
| AID308923 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 700699 by broth microdilution method | 2007 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 17, Issue:18 | Synthesis and in vitro antibacterial activity of novel methylamino piperidinyl oxazolidinones. |
| AID775533 | Inhibition of CYP1A2 in human liver microsomes assessed as ethoxyresorufin O-deethylation after 20 mins by fluorescence plate reader analysis | 2013 | European journal of medicinal chemistry, Nov, Volume: 69 | Synthesis and in vitro/in vivo antibacterial activity of oxazolidinones having thiocarbamate at C-5 on the A-ring and an amide- or urea-substituted [1,2,5]triazepane or [1,2,5]oxadiazepane as the C-ring. |
| AID525145 | Antimicrobial activity against linezolid-resistant Staphylococcus aureus isolate 004-737X expressing cfr and ermA gene isolated from paraplegic patient by Etest method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | First report of cfr-mediated resistance to linezolid in human staphylococcal clinical isolates recovered in the United States. |
| AID1151647 | Inhibition of MAO-A (unknown origin) using tyramine as substrate after 30 to 60 mins by fluorescence plate reader analysis | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID577136 | Total clearance in two-compartment pharmacokinetic/pharmacodynamic model at 200 mg, bid administered as 0.5 hr infusion over 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID558494 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus 547 measured on day 15 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID585166 | Antibacterial activity against Mycobacterium smegmatis harboring 23S rRNA C2499A2 mutant after 24 generation times | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Mutations in 23S rRNA at the peptidyl transferase center and their relationship to linezolid binding and cross-resistance. |
| AID67385 | In vitro antibacterial activity against vancomycin susceptible Enterococcus faecalis UC19217 (VSEF) | 2003 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 13, Issue:23 | The effect of remote chirality on the antibacterial activity of indolinyl, tetrahydroquinolyl and dihydrobenzoxazinyl oxazolidinones. |
| AID205839 | Minimum inhibitory concentration measured against Staphylococcus aureus | 2002 | Bioorganic & medicinal chemistry letters, Aug-19, Volume: 12, Issue:16 | The synthesis and biological evaluation of a novel series of antimicrobials of the oxazolidinone class. |
| AID585172 | Antibacterial activity against Mycobacterium smegmatis harboring 23S rRNA C2055A mutant after 24 generation times | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Mutations in 23S rRNA at the peptidyl transferase center and their relationship to linezolid binding and cross-resistance. |
| AID775546 | Antibacterial activity against linezolid-resistant Staphylococcus aureus NRS271 assessed as growth inhibition by broth microdilution method | 2013 | European journal of medicinal chemistry, Nov, Volume: 69 | Synthesis and in vitro/in vivo antibacterial activity of oxazolidinones having thiocarbamate at C-5 on the A-ring and an amide- or urea-substituted [1,2,5]triazepane or [1,2,5]oxadiazepane as the C-ring. |
| AID1154475 | Antibacterial activity against of methicillin-sensitive Staphylococcus aureus ATCC 19636 infected in iv dosed mouse assessed as host survival administered 1 hr after infection measured after 48 hrs | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | Design, synthesis, and structure-activity relationship studies of novel thioether pleuromutilin derivatives as potent antibacterial agents. |
| AID383560 | Antibacterial activity against Staphylococcus aureus ATCC 25923 by broth microdilution technique | 2008 | European journal of medicinal chemistry, Apr, Volume: 43, Issue:4 | Synthesis and in vitro antibacterial activities of novel oxazolidinones. |
| AID1375987 | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv after 2 weeks by microplate alamar blue assay | 2016 | MedChemComm, Nov-01, Volume: 7, Issue:11 | SAR and identification of 2-(quinolin-4-yloxy)acetamides as |
| AID630555 | Antibacterial activity against methicillin-resistant Staphylococcus aureus after 16 hrs by agar dilution method | 2011 | Journal of medicinal chemistry, Nov-10, Volume: 54, Issue:21 | Design, synthesis, and structure-activity relationship studies of highly potent novel benzoxazinyl-oxazolidinone antibacterial agents. |
| AID245185 | Minimum inhibitory concentration against Proteus vulgaris ATCC 8427; value ranges from 12-25 uM | 2004 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 14, Issue:22 | Aryl urea analogs with broad-spectrum antibacterial activity. |
| AID425653 | Renal clearance in human | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15 | Physicochemical determinants of human renal clearance. |
| AID528972 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus isolated from ICU patient blood assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID573145 | Antibacterial activity against penicillin-susceptible Streptococcus viridans assessed as resistant isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID549536 | Apparent permeability from apical to basolateral side of MDCK cells | 2011 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1 | MDCK cell permeability characteristics of a sulfenamide prodrug: strategic implications in considering sulfenamide prodrugs for oral delivery of NH-acids. |
| AID1677804 | Antibacterial activity against Staphylococcus aureus clinical isolate incubated for 24 hrs by CLSI-based broth microdilution method | 2020 | Bioorganic & medicinal chemistry, 11-01, Volume: 28, Issue:21 | Design, synthesis of novel 4,5-dihydroisoxazole-containing benzamide derivatives as highly potent FtsZ inhibitors capable of killing a variety of MDR Staphylococcus aureus. |
| AID295161 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus 04-5 infected po dosed KunMing mouse | 2007 | European journal of medicinal chemistry, Aug, Volume: 42, Issue:8 | Synthesis and antibacterial activity of oxazolidinones containing triazolyl group. |
| AID560818 | Antimicrobial activity against Mycobacterium tuberculosis in human adults with pulmonary tuberculosis at 600 mg administered twice for 7 days | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Population pharmacokinetics of linezolid in adults with pulmonary tuberculosis. |
| AID729218 | Antibacterial activity against linezolid-resistant Staphylococcus aureus after 16 hrs by NCCLS agar dilution method | 2013 | Journal of medicinal chemistry, Mar-28, Volume: 56, Issue:6 | Solubility-driven optimization of (pyridin-3-yl) benzoxazinyl-oxazolidinones leading to a promising antibacterial agent. |
| AID284960 | Antimicrobial activity against Corynebacterium spp. at 0.5 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID687498 | Volume of distribution in rat | 2012 | Bioorganic & medicinal chemistry, Oct-15, Volume: 20, Issue:20 | Antitubercular nitrofuran isoxazolines with improved pharmacokinetic properties. |
| AID730750 | Antibacterial activity against macrolides, lincosamides, and streptogramin B-resistant Streptococcus pneumoniae 1243-00 assessed as growth inhibition | 2013 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 23, Issue:6 | Novel 3-O-carbamoyl erythromycin A derivatives (carbamolides) with activity against resistant staphylococcal and streptococcal isolates. |
| AID285015 | Antimicrobial activity against Enterococcus raffinosus at 0.25 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID1241205 | Inhibition of pre-miR-372 (unknown origin) cleavage assessed as reduction of oncogenic microRNAs biogenesis by measuring fluorescence every minute for 5 hrs using 5'-FAM,3'-dabcyl-pre-miRNA beacons by FRET assay in presence of recombinant Dicer | 2015 | Bioorganic & medicinal chemistry, Sep-01, Volume: 23, Issue:17 | Ribosome-targeting antibiotics as inhibitors of oncogenic microRNAs biogenesis: Old scaffolds for new perspectives in RNA targeting. |
| AID1687312 | Synergistic antibacterial activity against wild type Escherichia coli BW25113 in presence of 0.25 times MIC of colistin incubated for 18 to 20 hrs by broth microdilution method | 2020 | European journal of medicinal chemistry, Jan-15, Volume: 186 | Development of benzimidazole-based derivatives as antimicrobial agents and their synergistic effect with colistin against gram-negative bacteria. |
| AID519490 | Antibacterial activity against Staphylococcus aureus T2019/50 expressing 23S rrn1 G2576T, rrn3 G2576T, rrn4 G2576T and rrn5 G2576T mutants by Etest method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Linezolid resistance in Staphylococcus aureus: gene dosage effect, stability, fitness costs, and cross-resistances. |
| AID424771 | Antifungal activity against Candida albicans MY1055 after 20 hrs by twofold serial broth dilution method | 2009 | Journal of natural products, May-22, Volume: 72, Issue:5 | Thiazomycins, thiazolyl peptide antibiotics from Amycolatopsis fastidiosa. |
| AID726200 | Antibacterial activity against methicillin-resistant Staphylococcus aureus C463 by agar dilution method | 2013 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 23, Issue:5 | Synthesis and antibacterial activities of new piperidine substituted (5R)-[1,2,3]triazolylmethyl and (5R)-[(4-F-[1,2,3]triazolyl)methyl] oxazolidinones. |
| AID576124 | Antibacterial activity against 2 x 10'8 CFU Enterococcus faecalis u810 infected in ICR mouse systemic infection model assessed as mouse protection administered orally twice after 1 and 4 hrs post infection measured after 48 hrs | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | In vitro and in vivo activities of LCB01-0371, a new oxazolidinone. |
| AID1126482 | Antimicrobial activity against penicillin- and erythromycin-resistant Streptococcus pneumoniae | 2014 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 24, Issue:8 | Synthesis, antibiotic activity and structure-activity relationship study of some 3-enaminetetramic acids. |
| AID319166 | Drug level in human urine | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7 | Linezolid (ZYVOX), the first member of a completely new class of antibacterial agents for treatment of serious gram-positive infections. |
| AID528849 | Antimicrobial activity against methicillin-susceptible Staphylococcus epidermidis isolated from ICU patient respiratory tract assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID576876 | Bactericidal activity against 12 hrs peripheral compartment culture samples of Enterococcus faecalis Ef1497 MutM3 in two-compartment pharmacokinetic/pharmacodynamic model assessed as effect on bacterial count at 600 mg, bid administered as 0.5 hr infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID23886 | Plasma clearance in Male Sprague-Dawley Rat (10 mg/kg iv) | 2003 | Journal of medicinal chemistry, Jan-16, Volume: 46, Issue:2 | Identification of phenylisoxazolines as novel and viable antibacterial agents active against Gram-positive pathogens. |
| AID245008 | In vitro minimum inhibitory concentration of compound against Mycobacterium smegmatis MTCC 006 | 2005 | Bioorganic & medicinal chemistry letters, Jan-17, Volume: 15, Issue:2 | Effects of positional and geometrical isomerism on the biological activity of some novel oxazolidinones. |
| AID1337725 | Inhibition of MAO activity in human HepG2 cells at 100 ug/mL after 24 hrs by spectrophotometric method | 2016 | European journal of medicinal chemistry, Nov-29, Volume: 124 | New isoxazolidinone and 3,4-dehydro-β-proline derivatives as antibacterial agents and MAO-inhibitors: A complex balance between two activities. |
| AID1432995 | Elimination half life in CD1 mouse at 10 mg/kg, po measured over 24 hrs by HPLC/MS/MS method | |||
| AID535026 | Antimicrobial activity against vancomycin intermediate Staphylococcus aureus NRS-26 expressing SCCmec type 2 element by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | In vitro activity of ceftaroline against community-associated methicillin-resistant, vancomycin-intermediate, vancomycin-resistant, and daptomycin-nonsusceptible Staphylococcus aureus isolates. |
| AID467837 | Antibacterial activity against floxacin and methicillin-resistant Staphylococcus aureus ATCC 25923 after 24 hrs by agar dilution method | 2009 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 19, Issue:23 | Novel 4-N-substituted aryl but-3-ene-1,2-dione derivatives of piperazinyloxazolidinones as antibacterial agents. |
| AID542892 | fCmax in Bacillus anthracis infected in vitro hollow fiber PK/PD model at simulated dose of 600 mg administered every 12 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID558491 | Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus 555 measured on day 15 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID291409 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus 04-4 after 18 to 24 hrs | 2007 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 17, Issue:16 | Synthesis and antibacterial activity of novel fluoroquinolones containing substituted piperidines. |
| AID581670 | Antibacterial activity against Staphylococcus aureus SCV isolated from cystic fibrosis patient in cation-adjusted MH 2 broth at pH 5.5 after 48 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Intracellular activity of antibiotics in a model of human THP-1 macrophages infected by a Staphylococcus aureus small-colony variant strain isolated from a cystic fibrosis patient: pharmacodynamic evaluation and comparison with isogenic normal-phenotype a |
| AID285007 | Antimicrobial activity against Enterococcus hirae at <= 0.06 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID575081 | Antimicrobial activity against Streptococcus pneumoniae serotype 6C assessed as percent susceptible isolates by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID558520 | Antimicrobial activity against heterogeneous vancomycin-intermediate Staphylococcus aureus 873 measured on day 30 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID565490 | Ratio of MBC to MIC for methicillin-resistant Staphylococcus aureus in presence of 50% human plasma | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro bactericidal activity of iclaprim in human plasma. |
| AID560819 | Cmax in human adults with pulmonary tuberculosis at 600 mg administered once daily for 5 days | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Population pharmacokinetics of linezolid in adults with pulmonary tuberculosis. |
| AID66115 | In vitro antibacterial activity against Enterococcus faecium ATCC 12202 (E.fm 154) vancomycin resistant | 2002 | Journal of medicinal chemistry, Aug-29, Volume: 45, Issue:18 | Synthesis of conformationally constrained analogues of linezolid: structure-activity relationship (SAR) studies on selected novel tricyclic oxazolidinones. |
| AID1400062 | Bactericidal activity against Bacillus subtilis ATCC 6051 incubated for 24 hrs under aerobic condition by MABA | 2018 | Bioorganic & medicinal chemistry, 09-15, Volume: 26, Issue:17 | An antimycobacterial pleuromutilin analogue effective against dormant bacilli. |
| AID1778104 | Antibacterial activity against linezolid resistant Staphylococcus capitis assessed as bacterial growth inhibition after 18 hrs by broth microdilution method | |||
| AID1056361 | Antibacterial activity against linezolid-resistant Staphylococcus aureus NRS271 clinical isolate harboring G2576T mutation in peptidyl transferase center domain V of 23S rRNA gene assessed as parasite growth inhibition by CLSI broth microdilution method | 2013 | ACS medicinal chemistry letters, Nov-14, Volume: 4, Issue:11 | Potent oxazolidinone antibacterials with heteroaromatic C-ring substructure. |
| AID483196 | Antibacterial activity against Escherichia coli ATCC 35218 by microbroth dilution technique | 2010 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 20, Issue:12 | Design, synthesis, and antibacterial activity of 2,5-dihydropyrrole formyl hydroxyamino derivatives as novel peptide deformylase inhibitors. |
| AID535033 | Antimicrobial activity against vancomycin intermediate Staphylococcus aureus NRS-118 expressing SCCmec type 1 element by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | In vitro activity of ceftaroline against community-associated methicillin-resistant, vancomycin-intermediate, vancomycin-resistant, and daptomycin-nonsusceptible Staphylococcus aureus isolates. |
| AID1167999 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis clinical isolate 387702 after overnight incubation by two-fold serial dilution method | 2014 | Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21 | Synthesis and biological evaluation of novel peptide BF2 as an antibacterial agent against clinical isolates of vancomycin-resistant enterococci. |
| AID520022 | Antimicrobial activity against Enterococcus faecalis A6350 | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID559777 | Antimicrobial activity against heterogeneous vancomycin-intermediate Staphylococcus aureus assessed as intermediate isolates by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID1898408 | Bactericidal activity against methicillin-resistant Staphylococcus aureus BAA-1707 planktonic cells assessed as planktonic eradication incubated for 24 hrs followed by incubation for overnight in fresh medium by Calgary biofilm device assay | 2021 | Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11 | A Modular Synthetic Route Involving |
| AID396027 | Antibacterial activity against drug-resistant Enterobacter cloacae EcDC64 isolate expressing AcrAB-TolC efflux pump in presence of 20 ug/ml efflux pump inhibitor Phe-Arg-beta-naphthylamide by Etest | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Cloning, nucleotide sequencing, and analysis of the AcrAB-TolC efflux pump of Enterobacter cloacae and determination of its involvement in antibiotic resistance in a clinical isolate. |
| AID1151763 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus isolate 15 in po dosed mouse systemic infection model | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID1312938 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus NRS119 clinical isolate after 20 hrs by broth microdilution method | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10 | Second-Generation Phenylthiazole Antibiotics with Enhanced Pharmacokinetic Properties. |
| AID283637 | Antimicrobial activity against Staphylococcus aureus RN4220 deltamutS with 23S rRNA G2576U and A2503G mutation | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | In vitro activity of the oxazolidinone RWJ-416457 against linezolid-resistant and -susceptible staphylococci and enterococci. |
| AID562237 | Chemical stability of the compound assessed as compound degradation at 16 times MIC after 24 hrs by RP-HPLC analysis | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Pharmacokinetic-pharmacodynamic modeling of the in vitro activities of oxazolidinone antimicrobial agents against methicillin-resistant Staphylococcus aureus. |
| AID1514454 | Antitubercular activity against d-cycloserine-resistant Mycobacterium tuberculosis after 7 days by resazurin dye based colorimetric assay | 2019 | Bioorganic & medicinal chemistry letters, 01-01, Volume: 29, Issue:1 | Synthesis, antituberculosis studies and biological evaluation of new quinoline derivatives carrying 1,2,4-oxadiazole moiety. |
| AID1553380 | Inhibition of CYP1A2 (unknown origin) | 2019 | Bioorganic & medicinal chemistry letters, 09-15, Volume: 29, Issue:18 | Incorporation of a chiral gem-disubstituted nitrogen heterocycle yields an oxazolidinone antibiotic with reduced mitochondrial toxicity. |
| AID1603313 | Antimicrobial activity against Escherichia coli SQ110 DTC measured after 16 hrs by broth microdilution method | 2019 | ACS medicinal chemistry letters, Mar-14, Volume: 10, Issue:3 | Expanded Structure-Activity Studies of Lipoxazolidinone Antibiotics. |
| AID1677797 | Bactericidal activity against Staphylococcus aureus clinical isolate assessed as reduction in number of colony forming units incubated for 24 hrs followed by re-plating and reincubation on tryptic soy agar plate for 24 hrs | 2020 | Bioorganic & medicinal chemistry, 11-01, Volume: 28, Issue:21 | Design, synthesis of novel 4,5-dihydroisoxazole-containing benzamide derivatives as highly potent FtsZ inhibitors capable of killing a variety of MDR Staphylococcus aureus. |
| AID295157 | Antibacterial activity against methicillin-resistant Staphylococcus epidermidis by microdilution broth method | 2007 | European journal of medicinal chemistry, Aug, Volume: 42, Issue:8 | Synthesis and antibacterial activity of oxazolidinones containing triazolyl group. |
| AID303917 | Antibacterial activity against Streptococcus pneumoniae ATCC 6303 after 24 hrs by agar dilution method | 2007 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 17, Issue:24 | Synthesis and antibacterial activity of potent heterocyclic oxazolidinones and the identification of RBx 8700. |
| AID1832941 | Antibacterial activity against Staphylococcus aureus USA 300 assessed as reduction in bacterial growth incubated for 20 hrs by microplate reader method | 2021 | Bioorganic & medicinal chemistry, 11-01, Volume: 49 | Synthesis, microbiological evaluation and structure activity relationship analysis of linezolid analogues with different C5-acylamino substituents. |
| AID370007 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus Smith infected in C3H mouse assessed as eradication at 25 mg/kg/day, po administered within 15 mins of infection assessed per gram of kidney measured after 48 hrs by organ burden | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vivo efficacy of a novel oxazolidinone compound in two mouse models of infection. |
| AID617500 | Antibacterial activity against Enterococcus faecalis ATCC 29212 by CLSI method | 2011 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 21, Issue:18 | Synthesis and in vitro activity of novel 1,2,4-triazolo[4,3-a]pyrimidine oxazolidinone antibacterial agents. Part II. |
| AID244990 | Antibacterial activity against Staphylococcus aureus FDA 209P was determined | 2004 | Bioorganic & medicinal chemistry letters, Oct-18, Volume: 14, Issue:20 | Synthesis and antibacterial activity of novel 6-fluoro-1-[(1R,2S)-2-fluorocyclopropan-1-yl]-4-oxoquinoline-3-carboxylic acids bearing cyclopropane-fused 2-amino-8-azabicyclo[4.3.0]nonan-8-yl substituents at the C-7 position. |
| AID263964 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis DRCC 153 | 2006 | Bioorganic & medicinal chemistry letters, May-01, Volume: 16, Issue:9 | Synthesis and antibacterial activity of novel oxazolidinones bearing N-hydroxyacetamidine substituent. |
| AID260738 | Antibacterial activity against Staphylococcus aureus 25293 | 2006 | Journal of medicinal chemistry, Feb-23, Volume: 49, Issue:4 | Hybrid antibacterials. DNA polymerase-topoisomerase inhibitors. |
| AID283396 | Antimicrobial activity against Nocardia veterana after 72 hrs by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | In vitro activities of tigecycline and eight other antimicrobials against different Nocardia species identified by molecular methods. |
| AID1076818 | Antitubercular activity against extensive drug-resistant Mycobacterium tuberculosis clinical isolate 7 assessed as growth inhibition by microdilution method | 2014 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 24, Issue:6 | Discovery of novel bis-oxazolidinone compounds as potential potent and selective antitubercular agents. |
| AID297957 | AUC in Streptococcus pneumoniae 548 infected mouse lung infection model at 40 mg/kg/day, po | 2007 | Journal of medicinal chemistry, Oct-04, Volume: 50, Issue:20 | Novel substituted (pyridin-3-yl)phenyloxazolidinones: antibacterial agents with reduced activity against monoamine oxidase A and increased solubility. |
| AID1390483 | Antibacterial activity against Enterococcus faecalis ATCC 19434 | 2018 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 28, Issue:7 | Design, synthesis and biological evaluation of spiropyrimidinetriones oxazolidinone derivatives as antibacterial agents. |
| AID1519040 | Antibacterial activity against clinical isolates of methicillin-resistant Staphylococcus aureus assessed as complete reduction in bacterial cell growth by CLSI protocol based broth liquid microdilution method | 2020 | European journal of medicinal chemistry, Jan-01, Volume: 185 | Optimization of biaryloxazolidinone as promising antibacterial agents against antibiotic-susceptible and antibiotic-resistant gram-positive bacteria. |
| AID574545 | Antimicrobial activity against community-associated methicillin-resistant Staphylococcus aureus USA300 | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Subinhibitory concentrations of protein synthesis-inhibiting antibiotics promote increased expression of the agr virulence regulator and production of phenol-soluble modulin cytolysins in community-associated methicillin-resistant Staphylococcus aureus. |
| AID1853450 | Antibacterial activity against Staphylococcus aureus ATCC 25923 assessed as bacterial growth inhibition incubated for 18 to 20 hrs by CLSI based broth microdilution assay | 2021 | RSC medicinal chemistry, Nov-17, Volume: 12, Issue:11 | SF |
| AID604287 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after 16 to 24 hrs by twofold serial dilution method | 2011 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 21, Issue:14 | 7-Alkyl-N(2)-substituted-3-deazaguanines. Synthesis, DNA polymerase III inhibition and antibacterial activity. |
| AID541072 | Tmax in cage fluid of Albino guiena pig at 25 mg/kg, ip | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Linezolid alone or combined with rifampin against methicillin-resistant Staphylococcus aureus in experimental foreign-body infection. |
| AID581665 | Antibacterial activity against Staphylococcus aureus SCV isolated from cystic fibrosis patient in cation-adjusted MH 2 broth assessed as log reduction of extracellular CFU level at up to 10'5 times MIC after 24 hrs | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Intracellular activity of antibiotics in a model of human THP-1 macrophages infected by a Staphylococcus aureus small-colony variant strain isolated from a cystic fibrosis patient: pharmacodynamic evaluation and comparison with isogenic normal-phenotype a |
| AID745400 | Antibacterial activity against Haemophilus influenzae SR27914 clinical isolate assessed as growth inhibition by CLSI broth microdilution method | 2013 | European journal of medicinal chemistry, May, Volume: 63 | Antibacterial oxazolidinone analogues having a N-hydroxyacetyl-substituted seven-membered [1,2,5]triazepane or [1,2,5]oxadiazepane C-ring unit. |
| AID1374171 | Antibacterial activity against Staphylococcus aureus ATCC 43300 incubated at 37 degC for 20 hrs by agar dilution method | 2018 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4 | Design, synthesis and antibacterial evaluation of honokiol derivatives. |
| AID285073 | Antimicrobial activity against viridans group Streptococcus anginosus at 0.25 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Activity of linezolid against 3,251 strains of uncommonly isolated gram-positive organisms: report from the SENTRY Antimicrobial Surveillance Program. |
| AID637978 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after overnight incubation by twofold broth dilution technique | 2012 | Bioorganic & medicinal chemistry, Jan-01, Volume: 20, Issue:1 | Efficient microwave-assisted synthesis, antibacterial activity and high fluorescence of 5 benzimidazolyl-2'-deoxyuridines. |
| AID1303420 | Antibacterial activity against vancomycin-resistant Enterococcus faecium infected in po dosed immunosuppressed mouse model assessed as inhibition of systemic infection administered bid for 3 days | 2016 | Bioorganic & medicinal chemistry letters, 07-01, Volume: 26, Issue:13 | Identification of novel aminopiperidine derivatives for antibacterial activity against Gram-positive bacteria. |
| AID1194831 | Antibacterial activity against Staphylococcus aureus ATCC 292135 incubated for 16 hrs by agar dilution method | 2015 | Bioorganic & medicinal chemistry letters, , Volume: 25, Issue:10 | Synthesis and structure-activity relationship studies of novel [6,6,5] tricyclic oxazolidinone derivatives as potential antibacterial agents. |
| AID1168005 | Antibacterial activity against vancomycin-resistant Enterococcus faecium clinical isolate 10177 after overnight incubation by two-fold serial dilution method | 2014 | Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21 | Synthesis and biological evaluation of novel peptide BF2 as an antibacterial agent against clinical isolates of vancomycin-resistant enterococci. |
| AID245104 | In vitro minimum inhibitory concentration against vancomycin-resistant Enterococcus faecium NCTC 12202 | 2005 | Bioorganic & medicinal chemistry letters, Jan-17, Volume: 15, Issue:2 | Effects of positional and geometrical isomerism on the biological activity of some novel oxazolidinones. |
| AID297127 | Antibacterial activity against Staphylococcus aureus FDA209P after 18 hrs by agar plate dilution method | 2007 | Journal of medicinal chemistry, Aug-23, Volume: 50, Issue:17 | Discovery of 1,4-dihydroxy-2-naphthoate [corrected] prenyltransferase inhibitors: new drug leads for multidrug-resistant gram-positive pathogens. |
| AID1449628 | Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-taurocholate transport into vesicles incubated for 5 mins by Topcount based rapid filtration method | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Dec, Volume: 40, Issue:12 | Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. |
| AID581030 | Bacteriostatic activity against Staphylococcus aureus ATCC 25923 at 8 times MIC after 30 hrs by time-kill analysis | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Mode of action of Ranbezolid against staphylococci and structural modeling studies of its interaction with ribosomes. |
| AID753113 | Antibacterial activity against Bacillus subtilis MTCC 121 assessed as growth inhibition at 20 mg/mL after 24 hrs | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | Anti-tubercular agents. Part 7: a new class of diarylpyrrole-oxazolidinone conjugates as antimycobacterial agents. |
| AID444259 | Antibacterial activity against Staphylococcus aureus ATCC 25923 by NCCLS method | 2009 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 19, Issue:22 | Synthesis and biological activity of novel oxazolidinones. |
| AID533404 | Antimicrobial activity against Clostridium subterminale assessed as resistant isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | In vitro activities of doripenem, a new broad-spectrum carbapenem, against recently collected clinical anaerobic isolates, with emphasis on the Bacteroides fragilis group. |
| AID304009 | AUC (0 to 24 hrs) in Sprague-Dawley rat plasma at 40 mg/kg/day after 14 days | 2007 | Journal of medicinal chemistry, Nov-29, Volume: 50, Issue:24 | Antibacterial oxazolidinones possessing a novel C-5 side chain. (5R)-trans-3-[3-Fluoro-4- (1-oxotetrahydrothiopyran-4-yl)phenyl]-2- oxooxazolidine-5-carboxylic acid amide (PF-00422602), a new lead compound. |
| AID576402 | Terminal half-life in two-compartment pharmacokinetic/pharmacodynamic model at 200 mg, bid administered as 0.5 hrs infusion | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype. |
| AID542688 | fT>MIC in Bacillus anthracis infected in vitro hollow fiber PK/PD model at simulated dose of 100 mg administered every 24 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID245196 | Minimum inhibitory concentration against heterogeneously methicillin-resistant Staphylococcus aureus A27218 | 2005 | Bioorganic & medicinal chemistry letters, Jun-02, Volume: 15, Issue:11 | Synthesis and antibacterial activity of dihydro-1,2-oxazine and 2-pyrazoline oxazolidinones: novel analogs of linezolid. |
| AID542679 | fCmax in Bacillus anthracis infected in vitro hollow fiber PK/PD model at simulated dose of 800 mg administered every 24 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID1180587 | Ratio of MIC for 2 times drug resistance selected Staphylococcus aureus ARC2398-1F to MIC for Staphylococcus aureus ARC2398 | 2014 | Journal of medicinal chemistry, Jul-24, Volume: 57, Issue:14 | Optimization of pyrrolamide topoisomerase II inhibitors toward identification of an antibacterial clinical candidate (AZD5099). |
| AID1327117 | Antitubercular activity against dormant stage Mycobacterium tuberculosis H37Ra at 30 ug/ml measured after 12 days by XTT assay | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Design, synthesis and biological evaluation of novel azaspiro analogs of linezolid as antibacterial and antitubercular agents. |
| AID1361112 | Bactericidal activity against vancomycin-intermediate Staphylococcus aureus NRS1 clinical isolate preincubated for 20 hrs followed by TSA plating and measured after 18 hrs | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | N-(1,3,4-oxadiazol-2-yl)benzamide analogs, bacteriostatic agents against methicillin- and vancomycin-resistant bacteria. |
| AID519085 | Antimicrobial activity against Escherichia coli KM85-86 harboring Lys157Gln mutation in rplC gene by agar dilution method in presence of 16 ug/ml polymyxin B nonapeptide | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Linezolid and tiamulin cross-resistance in Staphylococcus aureus mediated by point mutations in the peptidyl transferase center. |
| AID542684 | fAUC (24 hrs) in Bacillus anthracis infected in vitro hollow fiber PK/PD model at simulated dose of 500 mg administered every 24 hrs | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. |
| AID575048 | Cmin in medical patient plasma at 600 mg, iv or 600 mg, po administered every 12 hrs by HPLC | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Therapeutic drug monitoring of linezolid: a retrospective monocentric analysis. |
| AID540212 | Mean residence time in human after iv administration | 2008 | Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7 | Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. |
| AID558504 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus 547 measured on day 20 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID1271224 | Antibacterial activity against Streptococcus pneumoniae ATCC 6303 by microbroth dilution method | 2015 | ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11 | Design, Synthesis, and Identification of Silicon Incorporated Oxazolidinone Antibiotics with Improved Brain Exposure. |
| AID283622 | Antimicrobial activity against Enterococcus faecium 3 with homozygous 23S rRNA G2576U mutation | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | In vitro activity of the oxazolidinone RWJ-416457 against linezolid-resistant and -susceptible staphylococci and enterococci. |
| AID541064 | AUC (0 to 24 hrs) in cage fluid of Albino guiena pig at 25 mg/kg, ip | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Linezolid alone or combined with rifampin against methicillin-resistant Staphylococcus aureus in experimental foreign-body infection. |
| AID561244 | Antibacterial activity against methicillin-susceptible Staphylococcus epidermidis assessed as resistant isolates by CLSI M100-S17 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | AFN-1252, a FabI inhibitor, demonstrates a Staphylococcus-specific spectrum of activity. |
| AID205586 | Compound was evaluated for minimum inhibitory concentration against Staphylococcus epidermidis 9759 strain | 2002 | Bioorganic & medicinal chemistry letters, Mar-25, Volume: 12, Issue:6 | Synthesis and antibacterial activity of linezolid analogues. |
| AID387461 | Half life in Swiss albino mouse at 10 mg/kg, po | 2008 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 18, Issue:18 | Novel and potent oxazolidinone antibacterials featuring 3-indolylglyoxamide substituents. |
| AID562392 | Antimicrobial activity against Staphylococcus haemolyticus clinical isolates assessed as percent susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID1180584 | Ratio of MIC for 2 times drug resistance selected Staphylococcus aureus ARC1692-2F to MIC for Staphylococcus aureus ARC1692 | 2014 | Journal of medicinal chemistry, Jul-24, Volume: 57, Issue:14 | Optimization of pyrrolamide topoisomerase II inhibitors toward identification of an antibacterial clinical candidate (AZD5099). |
| AID1596561 | Bactericidal activity against Staphylococcus aureus NRS107 assessed as reduction in bacterial cell growth incubated for 18 to 20 hrs followed by re-plating on tryptic soy agar plates at 37 degC for 18 hrs by broth microdilution assay | 2019 | European journal of medicinal chemistry, Aug-01, Volume: 175 | Lipophilic efficient phenylthiazoles with potent undecaprenyl pyrophosphatase inhibitory activity. |
| AID562166 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus 543 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. |
| AID1151626 | Toxicity in female rat assessed as effect on mean corpuscular hemoglobin level at 100 mg/kg/day, po bid administered for 4 weeks (Rvb = 19.5 pg) | 2014 | Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. |
| AID1311361 | Antibacterial activity against Enterobacter cloacae ATCC 13047 measured after 18 hrs by broth microdilution assay | 2016 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15 | An evolved oxazolidinone with selective potency against Mycobacterium tuberculosis and gram positive bacteria. |
| AID1233138 | Antibacterial activity against patient-derived methicillin-resistant Staphylococcus aureus 7386 after 18 to 20 hrs by microbroth dilution method | 2015 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 25, Issue:13 | Thiol activated prodrugs of sulfur dioxide (SO2) as MRSA inhibitors. |
| AID745381 | Antibacterial activity against methicillin-resistant Staphylococcus aureus SR3637 infected in JCL/ICR mouse systemic infection model assessed as mortality administered as po measured over 7 days | 2013 | European journal of medicinal chemistry, May, Volume: 63 | Antibacterial oxazolidinone analogues having a N-hydroxyacetyl-substituted seven-membered [1,2,5]triazepane or [1,2,5]oxadiazepane C-ring unit. |
| AID1174912 | Cytotoxicity against human HepG2 cells at 100 ug/ml after 48 hrs by presto-blue staining-based assay | 2014 | Bioorganic & medicinal chemistry, Dec-15, Volume: 22, Issue:24 | New potent antibacterials against Gram-positive multiresistant pathogens: effects of side chain modification and chirality in linezolid-like 1,2,4-oxadiazoles. |
| AID1400047 | Bactericidal activity against Enterococcus faecalis ATCC 349 incubated for 24 hrs under aerobic condition by MABA | 2018 | Bioorganic & medicinal chemistry, 09-15, Volume: 26, Issue:17 | An antimycobacterial pleuromutilin analogue effective against dormant bacilli. |
| AID373838 | Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus 504 after 50 passages with vancomycin measured after 10 times antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. |
| AID1400036 | Bactericidal activity against Mycobacterium smegmatis ATCC 607 incubated for 48 hrs under aerobic condition by MABA | 2018 | Bioorganic & medicinal chemistry, 09-15, Volume: 26, Issue:17 | An antimycobacterial pleuromutilin analogue effective against dormant bacilli. |
| AID1603312 | Antimicrobial activity against Escherichia coli SQ110 measured after 16 hrs by broth microdilution method | 2019 | ACS medicinal chemistry letters, Mar-14, Volume: 10, Issue:3 | Expanded Structure-Activity Studies of Lipoxazolidinone Antibiotics. |
| AID548471 | Antibacterial activity against vancomycin-intermediate Staphylococcus aureus Mu50 after 48 hrs by Etest | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Contribution of vraSR and graSR point mutations to vancomycin resistance in vancomycin-intermediate Staphylococcus aureus. |
| AID583884 | Antibacterial activity against hospital-associated methicillin-resistant Staphylococcus aureus isolate 152 by broth microdilution assay | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Comparative efficacies of human simulated exposures of telavancin and vancomycin against methicillin-resistant Staphylococcus aureus with a range of vancomycin MICs in a murine pneumonia model. |
| AID528835 | Antimicrobial activity against vancomycin-resistant Enterococcus sp. isolated from ICU patient respiratory tract assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID532807 | Antibacterial activity against vancomycin-susceptible Staphylococcus aureus BR1 after 24 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Improved antimicrobial activity of linezolid against vancomycin-intermediate Staphylococcus aureus. |
| AID283615 | Antimicrobial activity against Enterococcus faecium Ho 5114-0276 with heterozygous 23S rRNA G2576U mutation | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | In vitro activity of the oxazolidinone RWJ-416457 against linezolid-resistant and -susceptible staphylococci and enterococci. |
| AID1904922 | Antibacterial activity against Vancomycin-resistant Staphylococcus aureus 12 incubated for 18 to 20 hrs by broth microdilution method | 2022 | European journal of medicinal chemistry, Apr-15, Volume: 234 | Exploring the structure-activity relationships of diphenylurea as an antibacterial scaffold active against methicillin- and vancomycin-resistant Staphylococcus aureus. |
| AID1161140 | Antimicrobial activity against Staphylococcus epidermidis after 24 hrs by broth microdilution method | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | Synthesis, antibacterial activity, and biological evaluation of formyl hydroxyamino derivatives as novel potent peptide deformylase inhibitors against drug-resistant bacteria. |
| AID1079938 | Chronic liver disease either proven histopathologically, or through a chonic elevation of serum amino-transferase activity after 6 months. Value is number of references indexed. [column 'CHRON' in source] | |||
| AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7 | A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7 | A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID1347095 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB-EBc1 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347103 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for OHS-50 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347101 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-12 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347086 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347107 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh30 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347094 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-37 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347092 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for A673 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347108 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh41 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347105 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for MG 63 (6-TG R) cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347093 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-MC cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347102 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh18 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347154 | Primary screen GU AMC qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 | Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347083 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347098 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-SH cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1508630 | Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay | 2021 | Cell reports, 04-27, Volume: 35, Issue:4 | A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. |
| AID1347106 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for control Hh wild type fibroblast cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347104 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for RD cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347089 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for TC32 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347090 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for DAOY cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347096 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for U-2 OS cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347099 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB1643 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347091 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SJ-GBM2 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347097 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Saos-2 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347082 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1745845 | Primary qHTS for Inhibitors of ATXN expression | |||
| AID1347100 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for LAN-5 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347059 | CD47-SIRPalpha protein protein interaction - Alpha assay qHTS validation | 2019 | PloS one, , Volume: 14, Issue:7 | Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors. |
| AID1347151 | Optimization of GU AMC qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 | Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347410 | qHTS for inhibitors of adenylyl cyclases using a fission yeast platform: a pilot screen against the NCATS LOPAC library | 2019 | Cellular signalling, 08, Volume: 60 | A fission yeast platform for heterologous expression of mammalian adenylyl cyclases and high throughput screening. |
| AID1347058 | CD47-SIRPalpha protein protein interaction - HTRF assay qHTS validation | 2019 | PloS one, , Volume: 14, Issue:7 | Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors. |
| AID1347057 | CD47-SIRPalpha protein protein interaction - LANCE assay qHTS validation | 2019 | PloS one, , Volume: 14, Issue:7 | Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors. |
| AID1347405 | qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS LOPAC collection | 2020 | ACS chemical biology, 07-17, Volume: 15, Issue:7 | High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle. |
| AID1159607 | Screen for inhibitors of RMI FANCM (MM2) intereaction | 2016 | Journal of biomolecular screening, Jul, Volume: 21, Issue:6 | A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 43 (1.15) | 18.2507 |
| 2000's | 1307 (34.94) | 29.6817 |
| 2010's | 1720 (45.98) | 24.3611 |
| 2020's | 671 (17.94) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.
| This Compound (113.60) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 222 (5.67%) | 5.53% |
| Reviews | 457 (11.67%) | 6.00% |
| Case Studies | 730 (18.64%) | 4.05% |
| Observational | 50 (1.28%) | 0.25% |
| Other | 2,457 (62.74%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized, Evaluator-Blinded, Phase 2 Study to Compare the Safety and Efficacy of PTK 0796 With Linezolid (Zyvox®) in the Treatment of Adults With Complicated Skin and Skin Structure Infection (cSSSI) [NCT03716024] | Phase 2 | 234 participants (Actual) | Interventional | 2007-07-18 | Completed | ||
| Patient-reported Experiences and Quality of Life Outcomes in the TB-PRACTECAL Clinical Trial [NCT03942354] | Phase 2/Phase 3 | 54 participants (Anticipated) | Interventional | 2019-09-01 | Recruiting | ||
| Population Pharmacokinetics of Linezolid in Intensive Care Units Patients Treated for Methicillin-Resistant Staphylococcus Aureus (MRSA) Infections [NCT01200654] | Phase 4 | 60 participants (Actual) | Interventional | 2007-11-30 | Completed | ||
| A Multicenter, Randomized, Double-blind, Parallel-group, Clinical Study of S-649266 Compared With Meropenem for the Treatment of Hospital-acquired Bacterial Pneumonia, Ventilator-associated Bacterial Pneumonia, or Healthcare-associated Bacterial Pneumonia [NCT03032380] | Phase 3 | 300 participants (Actual) | Interventional | 2017-10-24 | Completed | ||
| Retrospective Real-word Study of Linezolid for the Treatment of Tuberculous Meningitis [NCT03898635] | 150 participants (Anticipated) | Observational | 2018-01-01 | Recruiting | |||
| Evaluating Newly Approved Drugs for Multidrug-resistant TB (endTB): A Clinical Trial [NCT02754765] | Phase 3 | 754 participants (Actual) | Interventional | 2016-12-31 | Completed | ||
| A Phase 3 Randomized, Double-Blind, Multi-Center Study to Compare the Safety and Efficacy of Oral Omadacycline to Oral Linezolid for Treating Adult Subjects With Acute Bacterial Skin and Skin Structure Infection (ABSSSI) [NCT02877927] | Phase 3 | 735 participants (Actual) | Interventional | 2016-08-31 | Completed | ||
| Pilot Study of Linezolid for Early Syphilis Treatment [NCT05548426] | Phase 2 | 24 participants (Anticipated) | Interventional | 2023-09-28 | Recruiting | ||
| Single-Dose Linezolid Pharmacokinetics In Critically Ill Patients With Impaired Renal Function Especially Chronic Haemodialysis Patients [NCT02087566] | 18 participants (Actual) | Interventional | 2013-10-31 | Completed | |||
| Linezolid or Vancomycin Surgical Site Infection Prophylaxis [NCT05571722] | Phase 4 | 1,160 participants (Anticipated) | Interventional | 2023-04-03 | Not yet recruiting | ||
| Prospective Randomized Study to Compare Clinical Outcomes in Patients With Osteomyelitis Treated With Intravenous Antibiotics Versus Intravenous Antibiotics With an Early Switch to Oral Antibiotics [NCT02099240] | Early Phase 1 | 11 participants (Actual) | Interventional | 2014-03-06 | Terminated(stopped due to Not enough patient enrollment and lack of staffing) | ||
| A Randomized, Observer-blinded, Active-controlled, Phase Illb Study to Compare IV / Oral Delafloxacin Fixed-dose Monotherapy With Best Available Treatments in a Microbiologically Enriched Population With Surgical Site Infections [NCT04042077] | Phase 3 | 268 participants (Actual) | Interventional | 2019-09-25 | Terminated(stopped due to COVID-19 seriously affected the study execution as required by the protocol) | ||
| Cost Study of Linezolid Versus Vancomycin Among Previously Hospitalized Patients [NCT01363271] | 7,260 participants (Actual) | Observational | 2011-05-31 | Completed | |||
| Cost Effectiveness Of Linezolid Vs Vancomycin In The Treatment Of Ventilator Acquired Pneumonia In Central America [NCT01040585] | 0 participants (Actual) | Observational | 2010-07-31 | Withdrawn | |||
| Linezolid In The Treatment Of Subjects With Nosocomial Pneumonia Proven To Be Due To Methicillin-Resistant Staphylococcus Aureus [NCT00084266] | Phase 4 | 1,225 participants (Actual) | Interventional | 2004-10-31 | Completed | ||
| A Phase 3, Randomized, Double-Blind, Double-Dummy Study to Compare the Efficacy and Safety of Lefamulin (BC 3781) Versus Moxifloxacin (With or Without Adjunctive Linezolid) in Adults With Community-Acquired Bacterial Pneumonia [NCT02559310] | Phase 3 | 551 participants (Actual) | Interventional | 2015-09-30 | Completed | ||
| The Incidence of Linezolid-induced Thrombocytopenia (LIT) in Critically Ill Patients, the Risk Factors for LIT and Time to Events (LIT, Recovery) [NCT05944445] | 310 participants (Anticipated) | Observational | 2023-07-13 | Recruiting | |||
| A Randomized, Controlled, Double-Blind, Double Dummy, Multicenter Phase 2 Study of the Safety/Tolerability and Efficacy of JNJ-32729463 Compared With Linezolid (Zyvox) for the Treatment of Complicated Skin and Skin Structure Infection [NCT01128530] | Phase 2 | 161 participants (Actual) | Interventional | 2010-06-30 | Completed | ||
| Six- Versus Twelve-Week Therapy for Non-Surgically-Treated Diabetic Foot Osteomyelitis: A Multicenter Open-Label Controlled Randomized Study [NCT02123628] | Phase 4 | 40 participants (Actual) | Interventional | 2007-06-30 | Completed | ||
| Population Pharmacokinetics of Meropenem and Linezolid in Children With Severe Infectious Diseases [NCT03643497] | 800 participants (Anticipated) | Observational [Patient Registry] | 2018-07-01 | Recruiting | |||
| Evaluating Newly Approved Drugs in Combination Regimens for Multidrug-Resistant TB With Fluoroquinolone Resistance (endTB-Q) [NCT03896685] | Phase 3 | 323 participants (Actual) | Interventional | 2020-04-06 | Active, not recruiting | ||
| A Randomized, Double-blind, Multi-center Study to Evaluate the Safety and Efficacy of Oral Sodium Fusidate (CEM-102) Compared to Oral Linezolid in the Treatment of Acute Bacterial Skin and Skin Structure Infections [NCT02570490] | Phase 3 | 716 participants (Actual) | Interventional | 2015-11-30 | Completed | ||
| A Phase 2, Partially-blinded, Randomised Trial Assessing the Safety and Efficacy of TBAJ876 or Bedaquiline, in Combination With Pretomanid and Linezolid in Adult Participants With Newly Diagnosed, Drug-sensitive, Smear-positive Pulmonary Tuberculosis [NCT06058299] | Phase 2 | 300 participants (Anticipated) | Interventional | 2023-10-31 | Not yet recruiting | ||
| A Seamless Phase 2B/C Platform Trial to Evaluate Multiple Regimens and Durations of Treatment in Pulmonary Tuberculosis [NCT06114628] | Phase 2 | 2,500 participants (Anticipated) | Interventional | 2023-12-08 | Not yet recruiting | ||
| A Phase 3, Double-blinded, Randomized, Comparator Trial of the Safety and Efficacy of a Single Dose of Dalbavancin to Twice Daily Linezolid for the Treatment of Community Acquired Bacterial Pneumonia [NCT02269644] | Phase 3 | 0 participants (Actual) | Interventional | 2015-11-30 | Withdrawn | ||
| A Phase 3 Randomized Double-Blind Study Of Ceftobiprole Medocaril Versus Linezolid Plus Ceftazidime In The Treatment Of Nosocomial Pneumonia [NCT00229008] | Phase 3 | 106 participants (Actual) | Interventional | 2005-11-30 | Completed | ||
| A Phase 2, Randomized, Double-blind, Multi-center Study to Evaluate the Safety and Efficacy of CEM-102 Compared to Linezolid in the Treatment of Acute Bacterial Skin Structure Infections [NCT00948142] | Phase 2 | 198 participants (Actual) | Interventional | 2009-08-31 | Completed | ||
| Pharmacokinetic Properties of Antiretroviral and Related Drugs During Pregnancy and Postpartum [NCT00042289] | 1,578 participants (Actual) | Observational | 2003-06-09 | Completed | |||
| Finding the Optimal Regimen for Mycobacterium Abscessus Treatment (FORMaT) [NCT04310930] | Phase 2/Phase 3 | 300 participants (Anticipated) | Interventional | 2020-03-02 | Recruiting | ||
| Phase IIA Trial of the Safety and Tolerability of Increased Dose Rifampicin and Adjunctive Linezolid With or Without Aspirin, for HIV-associated Tuberculous Meningitis [NCT03927313] | Phase 2 | 52 participants (Actual) | Interventional | 2019-06-12 | Completed | ||
| Postoperative Antibiotic Management Duration Following Surgery for Intravenous Drug Abuse (IVDA) Endocarditis (OPTIMAL) [NCT05156437] | Phase 4 | 20 participants (Anticipated) | Interventional | 2022-03-16 | Enrolling by invitation | ||
| A Phase 2, Multicenter, Randomized, Double-Blind Study to Evaluate the Safety and Efficacy of Contezolid Acefosamil Compared to Linezolid Administered Intravenously and Orally to Adult Subjects With Acute Bacterial Skin and Skin Structure Infection [NCT03747497] | Phase 2 | 196 participants (Actual) | Interventional | 2018-11-15 | Completed | ||
| Pharmacokinetics/Pharmacodynamics of Oral Linezolid 300 mg/Day in Healthy Volunteers [NCT03841721] | Phase 1 | 30 participants (Actual) | Interventional | 2018-05-01 | Active, not recruiting | ||
| Oral and Neuro-Penetrative Alternative Antibiotics for Patients With Syphilis [NCT05069974] | Phase 3 | 224 participants (Anticipated) | Interventional | 2021-10-14 | Recruiting | ||
| Comparing Oral Versus Parenteral Antimicrobial Therapy (COPAT) Trial [NCT05977868] | Phase 4 | 135 participants (Anticipated) | Interventional | 2023-08-04 | Enrolling by invitation | ||
| A Multicenter, Randomized, Double-blind, Placebo-controlled Phase II Clinical Study of the Efficacy and Safety of 9MW1411 Injection Combined With Antibiotics in Patients With Acute Staphylococcus Aureus Skin and Skin Structure Infection [NCT05339802] | Phase 2 | 90 participants (Anticipated) | Interventional | 2022-02-16 | Recruiting | ||
| A Phase 3, Multicenter, Randomized, Double-Blind, Comparator-Controlled Study to Evaluate the Safety and Efficacy of Intravenous to Oral Delafloxacin in Adult Subjects With Community-Acquired Bacterial Pneumonia [NCT02679573] | Phase 3 | 860 participants (Actual) | Interventional | 2016-12-14 | Completed | ||
| A Randomized, Double-Blind, Multicenter Study of Ceftobiprole Medocaril Versus Placebo in the Treatment of Subjects Hospitalized With Community-Acquired Pneumonia [NCT00326287] | Phase 3 | 638 participants (Actual) | Interventional | 2006-06-30 | Completed | ||
| Comparative Effectiveness of Adjunctive Clindamycin Versus Linezolid for β-lactam Treated Patients With Invasive Group A Streptococcal Infections: A Target Trial Emulation [NCT06126263] | 1,000 participants (Anticipated) | Observational | 2023-01-01 | Active, not recruiting | |||
| Linezolid vs Vancomycin/Cefazolin in the Treatment of Hemodialysis Patients With Catheter-Related Gram-Positive Bloodstream Infections [NCT00108433] | Phase 3 | 61 participants (Actual) | Interventional | 2005-09-30 | Terminated(stopped due to See Detailed Description) | ||
| A Multicenter,Investigator-blinded,Randomized, Comparative Study to Evaluate the Efficacy and Safety of Oral NXL103 Versus Oral Linezolid in the Treatment of Acute Bacterial Skin and Skin Structure Infections (ABSSSI) [NCT00949130] | Phase 2 | 180 participants (Actual) | Interventional | 2009-11-30 | Completed | ||
| A Phase 1, Double-Blind, Randomized, Placebo-Controlled Study To Evaluate The Safety, Tolerability, Pharmacokinetics And Pharmacodynamics Of PNU-100480 (PF-02341272) After Administration Of Multiple Escalating Oral Doses To Healthy Adult Subjects [NCT00990990] | Phase 1 | 59 participants (Actual) | Interventional | 2009-10-31 | Completed | ||
| Determination of Pharmacokinetic and Therapeutic Adaptation of Linezolid in the Treatment of Multi-Resistant Tuberculosis MDR-TB [NCT02778828] | 31 participants (Actual) | Interventional | 2015-11-04 | Completed | |||
| Antibiotics in Cerebrospinal Fluid Following Intravenous Injection [NCT00925093] | Phase 1 | 0 participants (Actual) | Interventional | 2011-09-30 | Withdrawn(stopped due to Primary investigator left institution) | ||
| A Double-Blind, Placebo and Active Controlled, Single and Multiple Rising Dose, Safety, Tolerance, and Pharmacokinetic Study of TR-701 in Normal Healthy Adults [NCT00671814] | Phase 1 | 80 participants (Actual) | Interventional | 2008-01-06 | Completed | ||
| Linezolid Pharmacokinetics and Pharmacodynamics in the Treatment of Multi-Drug Resistant and Extensively-Drug Resistant Tuberculosis [NCT00691392] | Phase 1/Phase 2 | 26 participants (Actual) | Interventional | 2009-04-30 | Completed | ||
| Prospective Study Of Ophthalmologic Function In Patients Receiving Linezolid For Six Weeks Or Greater [NCT00359632] | Phase 3 | 34 participants (Actual) | Interventional | 2008-11-30 | Terminated(stopped due to Study was stopped due to poor enrollment on 28 Feb 2012. Reason for termination was not due to safety concerns.) | ||
| A Randomized, Double-Blind, Double Dummy, Comparative, Multicenter Study to Assess the Safety and Efficacy of Topical Retapamulin Ointment, 1%, Versus Oral Linezolid in the Treatment of Secondarily-Infected Traumatic Lesions and Impetigo Due to Methicilli [NCT00852540] | Phase 3 | 410 participants (Actual) | Interventional | 2009-04-30 | Completed | ||
| TBTC Study 30: A Phase I/II Pilot Study for Evaluation of Low Dose, Once Daily, Linezolid Plus Optimized Background Therapy (OBT) Versus Placebo Plus OBT for the Treatment of Multi-drug Resistant Tuberculosis [NCT00664313] | Phase 1/Phase 2 | 36 participants (Actual) | Interventional | 2009-04-30 | Completed | ||
| A Randomized, Evaluator-Blinded, Phase 3 Study to Compare the Safety and Efficacy of PTK 0796 With Linezolid in the Treatment of Adults With Complicated Skin and Skin Structure Infection [NCT00865280] | Phase 3 | 143 participants (Actual) | Interventional | 2009-04-04 | Terminated(stopped due to Terminated) | ||
| Pharmacokinetics and Pharmacodynamics Sub-study for TB-PRACTECAL Clinical Trial ( PRACTECAL-PKPD) [NCT04081077] | Phase 2/Phase 3 | 240 participants (Anticipated) | Interventional | 2019-08-06 | Active, not recruiting | ||
| Antibiotic Pharmacokinetics in Critically Ill Patients [NCT02609646] | 1,500 participants (Actual) | Observational | 2016-01-31 | Completed | |||
| Prospective Study Evaluating Plasma Exposure of Optimized Antibiotic Therapy According to TDM in Patients With Subarachnoid Haemorrhage (ES) and Cerebral Haemorrhage (EC) [NCT04132115] | 104 participants (Anticipated) | Observational | 2019-10-01 | Recruiting | |||
| A Randomised, Controlled, Open-Label, Phase II-III Trial to Evaluate the Safety and Efficacy of Regimens Containing Bedaquiline and Pretomanid for the Treatment of Adult Patients With Pulmonary Multidrug Resistant Tuberculosis [NCT02589782] | Phase 2/Phase 3 | 552 participants (Actual) | Interventional | 2017-01-31 | Active, not recruiting | ||
| Randomized Clinical Trial to Compare a Regimen of Trimethoprim-sulfamethoxazole (TMP-SMX) Plus Rifampicin With a Regimen of Linezolid in the Treatment of Infections Caused by Methicillin-resistant Staphylococcus Aureus (MRSA) [NCT00711854] | Phase 4 | 150 participants (Actual) | Interventional | 2009-01-31 | Completed | ||
| Linezolid vs. Vancomycin/Oxacillin/Dicloxacillin in the Treatment of Catheter-Related Gram-Positive Bloodstream Infections [NCT00037050] | Phase 3 | 739 participants (Actual) | Interventional | 2002-04-30 | Completed | ||
| Repurposing Clinically Approved Drugs for Yaws With an Insight Into the Cutaneous Ulcer Disease Syndrome (Trep-AByaws) [NCT05764876] | Phase 3 | 360 participants (Anticipated) | Interventional | 2023-03-14 | Recruiting | ||
| A Randomized, Evaluator-Blinded, Phase 3 Study to Compare the Safety and Efficacy of PTK 0796 With Linezolid in the Treatment of Adults With Complicated Skin and Skin Structure Infection [NCT00876850] | Phase 3 | 0 participants (Actual) | Interventional | 2009-07-31 | Withdrawn(stopped due to Terminated) | ||
| An Open Label, Single Dose, 2-Way, Randomized Cross-Over Bioequivalence Study Comparing Linezolid 600 Mg Oral Suspension With 600 Mg Tablet In Chinese Healthy Male Subjects [NCT01055769] | Phase 1 | 20 participants (Actual) | Interventional | 2010-03-31 | Completed | ||
| A Multicenter, Randomized, Observer-Blinded, Active-Controlled Study to Evaluate the Safety, Tolerability, Efficacy, and Pharmacokinetics of Ceftaroline Versus Comparator in Pediatric Subjects With Acute Bacterial Skin and Skin Structure Infections [NCT01400867] | Phase 2/Phase 3 | 163 participants (Actual) | Interventional | 2011-12-31 | Completed | ||
| Delamanid, Linezolid, Levofloxacin, and Pyrazinamide for the Treatment of Patients With Fluoroquinolone-sensitive MDR-TB: A Phase 2/3, Multicenter, Randomized, Open-label, Clinical Trial [NCT02619994] | Phase 2 | 238 participants (Anticipated) | Interventional | 2016-01-31 | Recruiting | ||
| Drug Use Investigation Of Zyvox (Linezolid) (Regulatory Post Marketing Commitment Plan) [NCT00666276] | 1,004 participants (Actual) | Observational | 2007-02-28 | Completed | |||
| The Effects of Linezolid and Vancomycin on Inflammation and Cellular Signaling Vents [NCT00811980] | 60 participants (Actual) | Observational | 2009-01-31 | Completed | |||
| Linezolid (PNU-10766/PNU10766SS) in the Treatment of MRSA Infections in Patients Whose Conventional Therapy Has Failed, or Who Are Intolerant to Conventional Therapy; an Open-label, Multi-center Trial [NCT00150332] | Phase 3 | 24 participants (Actual) | Interventional | 2003-01-31 | Completed | ||
| A Phase 2, Multicenter, Randomized, Open-Label, Comparative Study to Evaluate the Safety and Efficacy of RX-1741 Versus Linezolid in the Outpatient Treatment of Adult Patients With Uncomplicated Skin and Skin Structure Infection [NCT00646958] | Phase 2 | 150 participants (Actual) | Interventional | 2007-12-31 | Completed | ||
| A Single Center Four Part Study in Healthy Adult Subjects to Evaluate: the Safety, Tolerability and Pharmacokinetics of a Single Oral Dose and Repeat Escalating Oral Doses of GSK945237; the Effect of Linezolid on Hematology Safety Parameters; and the Effe [NCT01039610] | Phase 1 | 0 participants (Actual) | Interventional | 2009-11-30 | Withdrawn(stopped due to Internal decision to progress alternate molecule with more preferable profile) | ||
| Randomized, Open Label, Multiple Dose Phase I Study of the Early Bactericidal Activity of Linezolid, Gatifloxacin, Levofloxacin, and Moxifloxacin in HIV-non-infected Adults With Initial Episodes of Sputum Smear-Positive Pulmonary Tuberculosis [NCT00396084] | Phase 1/Phase 2 | 70 participants (Actual) | Interventional | 2004-02-10 | Completed | ||
| Linezolid in the Treatment of Subjects With Complicated Skin and Soft Tissue Infections Proven to be Due to Methicillin-Resistant Staphylococcus Aureus [NCT00087490] | Phase 4 | 1,077 participants (Actual) | Interventional | 2004-10-31 | Completed | ||
| Evaluation of the Early Bactericidal Activity of Tedizolid and Linezolide Against Mycobacterium Tuberculosis [NCT05534750] | Phase 2 | 60 participants (Anticipated) | Interventional | 2023-04-20 | Recruiting | ||
| Substitution of Ethambutol With Linezolid During the Intensive Phase of Treatment of Pulmonary Tuberculosis: A Prospective, Multicenter, Randomized, Open-label Phase II Trial [NCT01994460] | Phase 2 | 429 participants (Anticipated) | Interventional | 2014-01-31 | Recruiting | ||
| A Randomized, Open Label, Multi-Center Clinical Trial, Comparing Microbiologic Response To Linezolid And Vancomycin In Ventilator-Associated Pneumonia (VAP) Due To Methicillin Resistant Staphylococcus Aureus (MRSA) [NCT00572559] | Phase 4 | 149 participants (Actual) | Interventional | 2002-11-30 | Completed | ||
| Efficacy and Safety of Continuous Infusion of Linezolid Compared With Intermittent Dosing in Critically Ill Pneumonic Patients [NCT04531332] | 169 participants (Anticipated) | Interventional | 2019-11-15 | Recruiting | |||
| A Randomized, Controlled, Multi-center Clinical Trial of Short Course Treatment for Newly Diagnosed Rifampicin Resistant Tuberculosis [NCT04545788] | 200 participants (Anticipated) | Interventional | 2020-08-01 | Recruiting | |||
| Pharmacokinetics and Tolerability of Adjunctive Linezolid for the Treatment of Tuberculous Meningitis [NCT04021121] | Phase 2 | 60 participants (Anticipated) | Interventional | 2021-05-05 | Active, not recruiting | ||
| A Phase 2a, Randomized, 2-Arm, Open-Label, Clinical Trial of the Efficacy of Linezolid Combined With Antituberculous Therapy in Subjects With Extensively Drug-Resistant (XDR) Pulmonary Tuberculosis [NCT00727844] | Phase 2 | 41 participants (Actual) | Interventional | 2008-07-31 | Completed | ||
| Economic Evaluation of New MDR TB Regimens (PRACTECAL EE) [NCT04207112] | Phase 2/Phase 3 | 200 participants (Anticipated) | Interventional | 2020-10-20 | Recruiting | ||
| A Phase 3 Randomized, Double-Blind, Multicenter Study Comparing the Efficacy and Safety of 6-Day Oral TR-701 Free Acid and 10-Day Oral Linezolid for the Treatment of Acute Bacterial Skin and Skin Structure Infections [NCT01170221] | Phase 3 | 667 participants (Actual) | Interventional | 2010-08-15 | Completed | ||
| An Open-label, Placebo-controlled Phase 1 Study to Evaluate the Effect of Linezolid on Ex Vivo Neutrophil and Monocyte Function in Healthy Male Subjects [NCT01544673] | Phase 1 | 18 participants (Actual) | Interventional | 2012-03-31 | Completed | ||
| A Prospective, Randomized, Open, Active-controlled, Interventional, Exploratory, Phase II Trial to Evaluate the EBA, Safety and PK of Orally Administered LCB01-0371 in Adult Patients With Smear-positive Pulmonary Tuberculosis [NCT02836483] | Phase 2 | 79 participants (Actual) | Interventional | 2016-12-10 | Completed | ||
| An Investigator Initiated, Phase IV Single-Center, Randomized, Open-Label, Prospective Study to Determine the Impact of Serial Procalcitonin on Improving Antimicrobial Stewardship and on the Efficacy, Safety, and Tolerability of Imipenem - Relebactam Plus [NCT04983901] | Phase 2 | 100 participants (Actual) | Interventional | 2021-09-14 | Active, not recruiting | ||
| [NCT01756924] | Phase 2 | 14 participants (Actual) | Interventional | 2012-12-31 | Terminated(stopped due to This study has been terminated; alternative study designs are being considered. Fusidic acid remains available under an Expanded Access Protocol.) | ||
| Antibiotic Concentrations in Serum and Epithelial Lining Fluid Under Continous Infusion [NCT00435305] | 40 participants (Anticipated) | Observational | 2006-11-30 | Terminated(stopped due to difficulties by enrolling patients fundings consumed, no staff could be recruited and payed to continue enrolling patients,) | |||
| Short Intervention and Measurement of Pharmacokinetics of Linezolid in Tuberculosis Meningitis: a Pharmacokinetics and Safety/Tolerability Study [NCT03537495] | Phase 2 | 36 participants (Actual) | Interventional | 2021-06-21 | Completed | ||
| A Phase 2 Exploratory Study of Objective Endpoints in Subjects With Acute Bacterial Skin and Skin Structure Infections Treated With Delafloxacin, Vancomycin, or Linezolid [NCT01283581] | Phase 2 | 256 participants (Actual) | Interventional | 2011-01-31 | Completed | ||
| Refining MDR-TB Treatment (T) Regimens (R) for Ultra(U) Short(S) Therapy(T) (TB-TRUST)-PLUS [NCT04717908] | 89 participants (Actual) | Interventional | 2021-01-20 | Active, not recruiting | |||
| Phase 3, Randomized, Investigator-Blind, Multi-Center Study to Evaluate Efficacy and Safety of Intravenous Iclaprim Versus Linezolid in Complicated Skin and Skin Structure Infections (ASSIST-2) [NCT00303550] | Phase 3 | 0 participants | Interventional | 2006-03-31 | Completed | ||
| Prospective,Randomized,Open Label,European Multicenter Study of the Efficacy of the Linezolid-rifampin Combination Versus Standard of Care in the Treatment of Gram-positive. [NCT01757236] | Phase 2 | 100 participants (Anticipated) | Interventional | 2012-10-31 | Recruiting | ||
| A Randomized, Double Blind, Double Dummy Multicenter Phase IIa Study to Assess Safety, Tolerability and Efficacy of GSK1322322 Versus Linezolid in the Treatment of Acute Bacterial Skin and Skin Structure Infection [NCT01209078] | Phase 2 | 84 participants (Actual) | Interventional | 2010-08-17 | Completed | ||
| Clinical Usefulness of Mic/Breakpoint Ratio and Penetration in Tissues. A Prospective Study of Clinical Validation [NCT01551719] | 0 participants (Actual) | Interventional | 2012-03-31 | Withdrawn | |||
| A Phase I Clinical Study, Randomized, Double-blind, Placebo-controlled, Single Dose, Dose Escalation Study of the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of LCB01-0371 in Healthy Male Subjects [NCT01554995] | Phase 1 | 70 participants (Actual) | Interventional | 2012-03-31 | Completed | ||
| A Randomized, Double-Blind Trial Comparing Linezolid To Vancomycin In The Empiric Treatment Of Febrile Neutropenic Oncology Patients With Suspected Gram-Positive Infections [NCT00035425] | Phase 3 | 120 participants (Actual) | Interventional | 2001-11-30 | Completed | ||
| Linezolid IV/PO for the Treatment of Vancomycin-Resistant Enterococcus Infections in Children [NCT00035854] | Phase 3 | 13 participants (Actual) | Interventional | 2002-02-28 | Completed | ||
| Time To Efficacy and Onset Of Action Of Linezolid In Skin and Soft Tissue Infections [NCT00147511] | Phase 4 | 118 participants (Actual) | Interventional | 2003-06-30 | Completed | ||
| Concentration and Antibiotic Activity in Antibiotic Lock Solutions [NCT01592032] | Phase 4 | 125 participants (Anticipated) | Interventional | 2012-05-31 | Active, not recruiting | ||
| A Phase 3 Partially-blinded, Randomized Trial Assessing the Safety and Efficacy of Various Doses and Treatment Durations of Linezolid Plus Bedaquiline and Pretomanid in Participants With Pulmonary Infection of Either Extensively Drug-resistant Tuberculosi [NCT03086486] | Phase 3 | 181 participants (Actual) | Interventional | 2017-11-21 | Completed | ||
| "DART: Sivextro® in Acute Bacterial Skin anD Skin Structure Infection (ABSSSI) in Hospitalized Patients. A Global ObseRvational STudy." [NCT02991131] | 108 participants (Actual) | Observational | 2016-12-17 | Terminated(stopped due to Company decision) | |||
| Single Dose Safety, Tolerability And Pharmacokinetics Of Escalating Intravenous Doses Of Linezolid Followed By Evaluation Of The Effect Of Single Intravenous Doses Of Linezolid On QTc Interval In Healthy Subjects [NCT00795145] | Phase 1 | 49 participants (Actual) | Interventional | 2008-12-31 | Completed | ||
| A Phase 2, Multicenter, Randomized, Double-blind Study to Evaluate the Safety and Efficacy of MRX-I Versus Linezolid in Adult Subjects With Acute Bacterial Skin and Skin Structure Infection [NCT02269319] | Phase 2 | 120 participants (Actual) | Interventional | 2015-02-28 | Completed | ||
| Clinical Implication of Next Generation Sequencing of Urinary Bacteria in Patients With Low Colony Forming Units of Bacteria in Traditional Urine Culture [NCT05206500] | Phase 4 | 100 participants (Anticipated) | Interventional | 2022-05-17 | Recruiting | ||
| An Open Label Parallel Group Study To Investigate The Pharmacokinetics Of Intravenous Linezolid, An Oxazolidinone, Administered To Healthy Volunteers And Patients With Major Thermal Injuries [NCT00255996] | Phase 1 | 16 participants (Actual) | Interventional | 2006-05-31 | Completed | ||
| Zyvox (Linezolid) Special Investigation For Vancomycin-Resistant Enterococci (VRE)(Regulatory Post Marketing Commitment Plan) [NCT01224626] | 41 participants (Actual) | Observational | 2006-05-31 | Completed | |||
| Pharmacokinetic and Pharmacodynamic Evaluation of Linezolid Administered Intravenously in MRSA-positive, Morbidly Obese Patients With Pneumonia [NCT01805284] | Phase 4 | 15 participants (Actual) | Interventional | 2013-02-28 | Completed | ||
| A Phase 2 Dose-ranging Trial to Evaluate the Bactericidal Activity, Safety, Tolerability and Pharmacokinetics of Linezolid in Adult Subjects With Newly Diagnosed Drug-Sensitive, Smear-Positive Pulmonary Tuberculosis. [NCT02279875] | Phase 2 | 113 participants (Actual) | Interventional | 2014-11-30 | Completed | ||
| Phase 3, Randomized, Investigator-Blind, Multi-Center Study to Evaluate Efficacy and Safety of Intravenous Iclaprim Versus Linezolid in Complicated Skin and Skin Structure Infections.(ASSIST-1) [NCT00299520] | Phase 3 | 0 participants | Interventional | 2005-06-30 | Completed | ||
| Continuous Infusion Versus Intermittent Administration of Linezolid - Impact on Clinical Outcome and Adverse Reactions in Critically Ill Patients: a Pharmacokinetic and Pharmacodynamic Prospective Study [NCT05801484] | 60 participants (Anticipated) | Interventional | 2022-07-01 | Recruiting | |||
| A Phase 3, Randomized, Double-Blind, Double-Dummy Study to Compare the Efficacy and Safety of Dalbavancin to a Comparator Regiment (Vancomycin and Linezolid) for the Treatment of Acute Bacterial Skin and Skin Structure Infections [NCT01339091] | Phase 3 | 573 participants (Actual) | Interventional | 2011-03-31 | Completed | ||
| Early Oral Switch Therapy in Low-risk Staphylococcus Aureus Bloodstream Infection [NCT01792804] | Phase 3 | 215 participants (Actual) | Interventional | 2013-12-31 | Completed | ||
| A Pragmatic Randomized Controlled Trial to Evaluate the Efficacy and Safety of an Oral Short-course Regimen Including Bedaquiline for the Treatment of Patients With Multidrug-resistant Tuberculosis in China [NCT05306223] | Phase 4 | 212 participants (Anticipated) | Interventional | 2022-05-10 | Recruiting | ||
| A Phase 2, Multicenter, Randomized, Open-label, Comparative Study to Evaluate the Efficacy and Safety of Intramuscular Ceftaroline Versus Intravenous Linezolid in Adult Subjects With Complicated Skin and Skin Structure Infections [NCT00633152] | Phase 2 | 150 participants (Actual) | Interventional | 2008-02-29 | Completed | ||
| A Phase 3, Randomized, Double-Blind, Double-Dummy Study to Compare the Efficacy and Safety of Dalbavancin to a Comparator Regimen (Vancomycin and Linezolid) for the Treatment of Acute Bacterial Skin and Skin Structure Infections [NCT01431339] | Phase 3 | 739 participants (Actual) | Interventional | 2011-07-31 | Completed | ||
| Clinical Outcomes Among a National Veterans Affairs Methicillin Resistant Staphylococcus Aureus (MRSA) Pneumonia Cohort Treated With Linezolid Or Vancomycin [NCT01819935] | 5,271 participants (Actual) | Observational | 2012-12-31 | Completed | |||
| Safety and Efficacy of Strategy to Prevent Drug-Induced Nephrotoxicity in High-Risk Patients [NCT01734694] | Phase 4 | 100 participants (Actual) | Interventional | 2011-10-31 | Terminated(stopped due to Independent biostatistician recommended early termination of the trial due to low probability of success.) | ||
| Antimicrobial Treatment in Patients With Ventilator-associated Tracheobronchitis: a Prospective Randomized Placebo-controlled Double-blind Multicenter Trial [NCT03012360] | Phase 4 | 154 participants (Anticipated) | Interventional | 2018-02-08 | Recruiting | ||
| Population Pharmacokinetics of Commonly Used Antimicrobial Agents in Children of Bacterial Meningitis With Augmented Renal Clearance [NCT04771884] | 300 participants (Anticipated) | Observational | 2020-10-01 | Recruiting | |||
| A Phase 3 Randomized Double-blind Study Comparing TR-701 FA and Linezolid in Ventilated Gram-positive Nosocomial Pneumonia [NCT02019420] | Phase 3 | 726 participants (Actual) | Interventional | 2014-01-06 | Completed | ||
| Pharmacokinetics of Linezolid in Children With Cystic Fibrosis [NCT00625703] | Phase 2 | 45 participants (Actual) | Interventional | 2010-12-31 | Completed | ||
| Two-month Regimens Using Novel Combinations to Augment Treatment Effectiveness for Drug-sensitive Tuberculosis [NCT03474198] | Phase 2/Phase 3 | 675 participants (Actual) | Interventional | 2018-03-21 | Completed | ||
| Prospective, Randomized, Open Label Phase 3 Study of the Efficacy and Tolerability of Delamanid, Linezolid, Pyrazinamide and Levofloxacin for Treatment of Patients With Fluoroquinolone-susceptible Multidrugresistant--Tuberculosis (MDR-TB) [NCT02975570] | Phase 3 | 0 participants (Actual) | Interventional | 2017-08-31 | Withdrawn(stopped due to The study could not be conducted since funding was not obtained.) | ||
| A Prospective Implementation of an IV-oral Switch Policy to Treat Proven or Suspected Infections Due to Resistant Gram Positive Bacteria in a London Hospital Trust [NCT00501150] | 211 participants (Actual) | Interventional | 2005-09-30 | Completed | |||
| An Open Label, Randomized Controlled Trial to Establish the Efficacy and Safety of a Study Strategy Consisting of 6 Months of Bedaquiline (BDQ), Delamanid (DLM), and Linezolid (LNZ), With Levofloxacin (LVX) and Clofazimine (CFZ) Compared to the Current So [NCT04062201] | Phase 3 | 402 participants (Actual) | Interventional | 2019-08-22 | Active, not recruiting | ||
| Asymptomatic Colonization With S. Aureus After Therapy With Linezolid or Clindamycin for Acute S. Aureus Skin and Skin Structure Infections in Patients With Comorbid Conditions: A Randomized Trial [NCT01619410] | 25 participants (Actual) | Interventional | 2012-01-31 | Terminated(stopped due to slow accrual) | |||
| A Multicenter, Randomized, Open-Label Study To Evaluate The Efficacy And Safety Of A Contezolid, Delamanid and Bedaquiline-Containing Short Regimen For The Treatment Of Rifampicin-Resistant Pulmonary Tuberculosis [NCT06081361] | Phase 3 | 186 participants (Anticipated) | Interventional | 2023-11-01 | Not yet recruiting | ||
| Prospective, Randomized, Partially Blinded, Phase 2 Study of the Efficacy and Tolerability of Bedaquiline, Delamanid, Levofloxacin, Linezolid, and Clofazimine for Treatment of Patients With MDR-TB [NCT03828201] | Phase 2 | 220 participants (Anticipated) | Interventional | 2022-06-07 | Recruiting | ||
| Multicenter, Retrospective, Observational Study to Evaluate Clinical and Economic Outcomes of Patients With MRSA Hospital-Acquired Pneumonia Treated With Linezolid Or Vancomycin [NCT01561469] | 188 participants (Actual) | Observational | 2008-11-30 | Completed | |||
| A Phase III Randomized Double-Blind Study Of Ceftobiprole Versus Linezolid Plus Ceftazidime In The Treatment Of Nosocomial Pneumonia [NCT00210964] | Phase 3 | 781 participants (Actual) | Interventional | 2005-04-30 | Completed | ||
| A Phase III, Randomized, Double-Blind, Active Comparator-Controlled Clinical Trial to Study the Safety, Tolerability, and Efficacy of Imipenem/Cilastatin/Relebactam (MK-7655A) Versus Piperacillin/Tazobactam in Subjects With Hospital-Acquired Bacterial Pne [NCT02493764] | Phase 3 | 537 participants (Actual) | Interventional | 2015-11-24 | Completed | ||
| Impact of Aggressive Empiric Antibiotic Therapy and Duration of Therapy on the Emergence of Antimicrobial Resistance During the Treatment of Hospitalized Subjects With Pneumonia Requiring Mechanical Ventilation [NCT01570192] | Phase 2 | 43 participants (Actual) | Interventional | 2010-09-30 | Terminated(stopped due to NIAID terminated the study due to low subject enrollment) | ||
| A Phase 3 Randomized, Double-Blind, Multicenter Study Comparing the Efficacy and Safety of IV to Oral 6-Day TR-701 Free Acid and IV to Oral 10-Day Linezolid for the Treatment of ABSSSI [NCT01421511] | Phase 3 | 666 participants (Actual) | Interventional | 2011-09-15 | Completed | ||
| A Phase II, Prospective, Randomized, Multicenter Trial to Evaluate the Efficacy and Safety/Tolerability of Two Linezolid Dosing Strategies in Combination With a Short Course Regimen for the Treatment of Drug-Resistant Pulmonary Tuberculosis [NCT05007821] | Phase 2 | 132 participants (Anticipated) | Interventional | 2022-08-11 | Recruiting | ||
| A Prospective, Randomized, Open-label, Active-controlled, Multicenter Study to Evaluate the Efficacy and Safety of BAY 1192631 in Japanese Patients With MRSA Infections (Skin and Soft Tissue Infection [SSTI] and SSTI-related Bacteremia) [NCT01967225] | Phase 3 | 125 participants (Actual) | Interventional | 2013-11-23 | Completed | ||
| A Phase III, Multi-centre, Randomized Study to Compare the Efficacy and Safety of Levonadifloxacin (IV and Oral) With Linezolid (IV and Oral) in Acute Bacterial Skin and Skin Structure Infections (ABSSSI) [NCT03405064] | Phase 3 | 501 participants (Actual) | Interventional | 2017-08-25 | Completed | ||
| A Phase 3, Multicenter, Randomized, Double-Blind Study to Evaluate the Safety and Efficacy of Contezolid Acefosamil and Contezolid Compared to Linezolid Administered Intravenously and Orally to Adults With Moderate or Severe Diabetic Foot Infections (DFI) [NCT05369052] | Phase 3 | 865 participants (Anticipated) | Interventional | 2022-05-03 | Recruiting | ||
| Evaluating a New Treatment Regimen for Patients With Multidrug-resistant TB (MDR-TB) - a Prospective Open-label Randomised Controlled Trial [NCT02454205] | Phase 2/Phase 3 | 154 participants (Actual) | Interventional | 2015-11-12 | Completed | ||
| Post Marketing Surveillance on the Efficacy, Safety and Tolerability of Linezolid (Zyvox) in the Treatment of Gram Positive Infections [NCT01564758] | 99 participants (Actual) | Observational | 2004-02-29 | Completed | |||
| A Phase 3 Open-label Trial Assessing the Safety and Efficacy of Bedaquiline Plus PA-824 Plus Linezolid in Subjects With Pulmonary Infection of Either Extensively Drug-resistant Tuberculosis (XDR-TB) or Treatment Intolerant / Non-responsive Multi-drug Resi [NCT02333799] | Phase 3 | 109 participants (Actual) | Interventional | 2015-03-31 | Completed | ||
| Phase 3 Study of IV to Oral 6-Day Tedizolid Phosphate Compared With 10-day Comparator in Subjects 12 to < 18 Years With cSSTI. [NCT02276482] | Phase 3 | 120 participants (Actual) | Interventional | 2015-03-25 | Completed | ||
| Oral Antimicrobial Treatment vs. Outpatient Parenteral for Infective Endocarditis [NCT05398679] | Phase 4 | 360 participants (Anticipated) | Interventional | 2022-06-01 | Not yet recruiting | ||
| A Phase 2, Randomized, Double-Blind, Multicenter Study of Safety, Tolerability, and Efficacy of Debio 1450 vs Vancomycin (IV)/Linezolid (Oral) in the Treatment of Acute Bacterial Skin and Skin Structure Infections (ABSSSI) Due to Staphylococcus Sensitive [NCT02426918] | Phase 2 | 330 participants (Actual) | Interventional | 2015-05-31 | Completed | ||
| A Single-Center, Randomized, Open-label, Prospective, Comparative Study to Determine the Efficacy, Safety, and Tolerability of Ceftazidime-Avibactam (CAZ-AVI) Plus Vancomycin or Linezolid Versus Standard of Care Plus Vancomycin or Linezolid as Empiric The [NCT02732327] | Phase 2 | 2 participants (Actual) | Interventional | 2016-05-17 | Terminated(stopped due to No longer aligned with the revised clinical development plan and commercial strategy) | ||
| A Phase 3 Randomized, Double-blind, Multi-center Study to Compare the Safety and Efficacy of Omadacycline IV/PO to Linezolid IV/PO for Treating Adults With Acute Bacterial Skin and Skin Structure Infections (ABSSSI) [NCT02378480] | Phase 3 | 655 participants (Actual) | Interventional | 2015-06-30 | Completed | ||
| A Phase II, Randomized, Open-Label Trial of a Six-Month Regimen of High-Dose Rifampicin, High-Dose Isoniazid, Linezolid, and Pyrazinamide Versus a Standard Nine-Month Regimen for the Treatment of Adults and Adolescents With Tuberculous Meningitis: Improve [NCT05383742] | Phase 2 | 330 participants (Anticipated) | Interventional | 2024-01-02 | Not yet recruiting | ||
| Evaluate the Effectiveness, Safety and Tolerability of Various Doses of Linezolid in Combination With Bedaquiline and Pretomanid in Adults With Pre-Extensively Drug-Resistant (Pre-XDR), Or Treatment Intolerant/Non-responsive Multidrug-Resistant (MDRTI/NR) [NCT05040126] | Phase 3 | 400 participants (Anticipated) | Interventional | 2021-10-07 | Recruiting | ||
| A Multi-national Phase 3, Randomized, Double-Blind, Active Comparator-Controlled Clinical Trial to Study the Safety, Tolerability, and Efficacy of Imipenem/Cilastatin/Relebactam (MK-7655A) Versus Piperacillin/Tazobactam in Subjects With Hospital-Acquired [NCT03583333] | Phase 3 | 274 participants (Actual) | Interventional | 2018-09-18 | Completed | ||
| A Phase 3 Randomized, Double-Blind, Multicenter Study Comparing the Efficacy and Safety of Intravenous to Oral 6-Day Tedizolid Phosphate and Intravenous to Oral 10-Day Linezolid for the Treatment of Acute Bacterial Skin and Skin Structure Infections [NCT02066402] | Phase 3 | 598 participants (Actual) | Interventional | 2014-03-04 | Completed | ||
| Efficacy and Safety of Continuous Versus Intermittent Linezolid Infusion in Critically Ill Patients With Septic Shock [NCT05813951] | 140 participants (Anticipated) | Interventional | 2022-12-02 | Recruiting | |||
| Efficacy of Oral Antibiotic Therapy Compared to Intravenous Antibiotic Therapy for the Treatment of Diabetic Foot Osteomyelitis (CRO-OSTEOMYELITIS) [NCT02168816] | Phase 2 | 30 participants (Actual) | Interventional | 2014-03-19 | Terminated(stopped due to The study was stopped for feasibility (i.e., low recruitment)) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||