Proteins > Solute carrier family 15 member 1
Page last updated: 2024-08-07 18:35:40
Solute carrier family 15 member 1
A solute carrier family 15 member 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P46059]
Synonyms
Intestinal H(+)/peptide cotransporter;
Oligopeptide transporter, small intestine isoform;
Peptide transporter 1
Research
Bioassay Publications (25)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 12 (48.00) | 18.2507 |
| 2000's | 8 (32.00) | 29.6817 |
| 2010's | 4 (16.00) | 24.3611 |
| 2020's | 1 (4.00) | 2.80 |
Compounds (118)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| aminolevulinic acid | Homo sapiens (human) | Ki | 790.0000 | 1 | 1 |
| 5-aminovaleric acid | Homo sapiens (human) | Ki | 17,400.0000 | 1 | 1 |
| alanylalanine | Homo sapiens (human) | Ki | 120.0000 | 1 | 1 |
| cephaloridine | Homo sapiens (human) | Ki | 30,000.0000 | 1 | 1 |
| floxuridine | Homo sapiens (human) | IC50 | 12,210.0000 | 1 | 1 |
| penicillin g | Homo sapiens (human) | Ki | 30,000.0000 | 2 | 2 |
| cephalothin | Homo sapiens (human) | Ki | 10,000.0000 | 2 | 2 |
| levodopa | Homo sapiens (human) | IC50 | 141,200.0000 | 1 | 1 |
| cloxacillin | Homo sapiens (human) | Ki | 2,750.0000 | 2 | 2 |
| oxacillin | Homo sapiens (human) | Ki | 12,000.0000 | 2 | 2 |
| ampicillin | Homo sapiens (human) | IC50 | 10,000.0000 | 1 | 1 |
| ampicillin | Homo sapiens (human) | Ki | 14,750.0000 | 2 | 2 |
| penicillin v | Homo sapiens (human) | Ki | 21,000.0000 | 1 | 1 |
| aminopenicillanic acid | Homo sapiens (human) | Ki | 30,000.0000 | 1 | 1 |
| glycyl-glycyl-glycine | Homo sapiens (human) | IC50 | 1,235.0000 | 2 | 2 |
| glycylglycine | Homo sapiens (human) | IC50 | 820.0000 | 1 | 1 |
| glycylglycine | Homo sapiens (human) | Ki | 1,000.0000 | 2 | 2 |
| dicloxacillin | Homo sapiens (human) | Ki | 7,200.0000 | 2 | 2 |
| cyclacillin | Homo sapiens (human) | IC50 | 475.0000 | 2 | 2 |
| cyclacillin | Homo sapiens (human) | Ki | 500.0000 | 2 | 2 |
| floxacillin | Homo sapiens (human) | Ki | 3,200.0000 | 1 | 1 |
| cephalexin | Homo sapiens (human) | IC50 | 9,450.0000 | 2 | 2 |
| cephalexin | Homo sapiens (human) | Ki | 14,200.0000 | 2 | 2 |
| cephapirin | Homo sapiens (human) | Ki | 10,000.0000 | 2 | 2 |
| cefazolin | Homo sapiens (human) | Ki | 30,000.0000 | 1 | 1 |
| amoxicillin | Homo sapiens (human) | Ki | 10,000.0000 | 1 | 1 |
| cephradine | Homo sapiens (human) | IC50 | 15,150.0000 | 2 | 2 |
| cephradine | Homo sapiens (human) | Ki | 4,904.9000 | 2 | 2 |
| methyldopa | Homo sapiens (human) | IC50 | 151,600.0000 | 1 | 1 |
| cefmetazole | Homo sapiens (human) | Ki | 28,000.0000 | 2 | 2 |
| piperacillin | Homo sapiens (human) | Ki | 30,000.0000 | 1 | 1 |
| moxalactam | Homo sapiens (human) | Ki | 12,150.0000 | 2 | 2 |
| cefadroxil anhydrous | Homo sapiens (human) | IC50 | 3,135.0000 | 2 | 2 |
| cefadroxil anhydrous | Homo sapiens (human) | Ki | 6,237.5000 | 4 | 4 |
| cefaclor anhydrous | Homo sapiens (human) | IC50 | 8,200.0000 | 1 | 1 |
| cefaclor anhydrous | Homo sapiens (human) | Ki | 10,000.0000 | 2 | 2 |
| tyrosyltyrosine | Homo sapiens (human) | IC50 | 60.0000 | 1 | 1 |
| leucyl-glycyl-glycine | Homo sapiens (human) | Ki | 390.0000 | 1 | 1 |
| leucylleucine | Homo sapiens (human) | IC50 | 170.0000 | 1 | 1 |
| tamiflu | Homo sapiens (human) | IC50 | 27,400.0000 | 1 | 1 |
| leucyl-alanine | Homo sapiens (human) | Ki | 120.0000 | 1 | 1 |
| alanylproline | Homo sapiens (human) | Ki | 150.0000 | 1 | 1 |
| phenylalanylphenylalanylamide | Homo sapiens (human) | IC50 | 80.0000 | 1 | 1 |
| Trp-Trp | Homo sapiens (human) | IC50 | 250.0000 | 1 | 1 |
| glycyltryptophan | Homo sapiens (human) | IC50 | 520.0000 | 1 | 1 |
| glycyltyrosine | Homo sapiens (human) | IC50 | 120.0000 | 1 | 1 |
| glycylleucine | Homo sapiens (human) | IC50 | 70.0000 | 1 | 1 |
| glycylleucine | Homo sapiens (human) | Ki | 160.0000 | 1 | 1 |
| alanyltyrosine | Homo sapiens (human) | IC50 | 170.0000 | 1 | 1 |
| alanyltyrosine | Homo sapiens (human) | Ki | 150.0000 | 1 | 1 |
| glycyl-l-phenylalanine | Homo sapiens (human) | IC50 | 170.0000 | 1 | 1 |
| glycylsarcosine | Homo sapiens (human) | IC50 | 1,160.0000 | 1 | 1 |
| glycylsarcosine | Homo sapiens (human) | Ki | 6,815.0000 | 2 | 2 |
| alanylphenylalanine | Homo sapiens (human) | IC50 | 70.0000 | 1 | 1 |
| prolyl-glycyl-glycine | Homo sapiens (human) | Ki | 16,000.0000 | 1 | 1 |
| tryptophylglycine | Homo sapiens (human) | IC50 | 730.0000 | 1 | 1 |
| glycylaspartic acid | Homo sapiens (human) | IC50 | 380.0000 | 1 | 1 |
| glycylaspartic acid | Homo sapiens (human) | Ki | 350.0000 | 1 | 1 |
| n-glycylglutamic acid | Homo sapiens (human) | IC50 | 650.0000 | 1 | 1 |
| histidylglycine | Homo sapiens (human) | IC50 | 340.0000 | 1 | 1 |
| histidinoalanine | Homo sapiens (human) | Ki | 480.0000 | 1 | 1 |
| valylvaline | Homo sapiens (human) | IC50 | 210.0000 | 1 | 1 |
| tyrosyl-glycyl-glycine | Homo sapiens (human) | Ki | 350.0000 | 1 | 1 |
| glycyl-leucyl-phenylalanine | Homo sapiens (human) | IC50 | 980.0000 | 1 | 1 |
| lysyllysine | Homo sapiens (human) | IC50 | 10,900.0000 | 1 | 1 |
| alanylglutamic acid | Homo sapiens (human) | Ki | 320.0000 | 1 | 1 |
| prolylarginine | Homo sapiens (human) | Ki | 2,500.0000 | 1 | 1 |
| aspartylglycine | Homo sapiens (human) | IC50 | 810.0000 | 1 | 1 |
| arginylarginine | Homo sapiens (human) | IC50 | 7,310.0000 | 1 | 1 |
| prolyl-tyrosine | Homo sapiens (human) | Ki | 730.0000 | 1 | 1 |
| n-valyltryptophan | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| prolylglutamic acid | Homo sapiens (human) | IC50 | 12,300.0000 | 1 | 1 |
| prolylglutamic acid | Homo sapiens (human) | Ki | 20,000.0000 | 2 | 2 |
| cysteinylglycine | Homo sapiens (human) | Ki | 200.0000 | 2 | 2 |
| glutamyl-glutamic acid | Homo sapiens (human) | IC50 | 620.0000 | 1 | 1 |
| cefoxitin | Homo sapiens (human) | Ki | 10,000.0000 | 1 | 1 |
| 7-aminocephalosporanic acid | Homo sapiens (human) | Ki | 10,000.0000 | 1 | 1 |
| cefamandole | Homo sapiens (human) | Ki | 8,100.0000 | 2 | 2 |
| aspartyl-aspartic acid | Homo sapiens (human) | IC50 | 630.0000 | 1 | 1 |
| aspartyl-aspartic acid | Homo sapiens (human) | Ki | 410.0000 | 2 | 2 |
| cefsulodin | Homo sapiens (human) | Ki | 30,000.0000 | 1 | 1 |
| n-glycylalanine | Homo sapiens (human) | IC50 | 1,820.0000 | 1 | 1 |
| glycylproline | Homo sapiens (human) | IC50 | 330.0000 | 1 | 1 |
| glycylproline | Homo sapiens (human) | Ki | 300.0000 | 2 | 2 |
| glycyllysine | Homo sapiens (human) | IC50 | 1,250.0000 | 1 | 1 |
| trimethionine | Homo sapiens (human) | Ki | 310.0000 | 1 | 2 |
| seryl-proline | Homo sapiens (human) | Ki | 130.0000 | 1 | 1 |
| 7432 s | Homo sapiens (human) | Ki | 565.0000 | 4 | 4 |
| cefodizime | Homo sapiens (human) | Ki | 22,000.0000 | 2 | 2 |
| cefixime | Homo sapiens (human) | IC50 | 10,000.0000 | 1 | 1 |
| cefixime | Homo sapiens (human) | Ki | 8,436.6667 | 3 | 3 |
| enalapril | Homo sapiens (human) | IC50 | 9,750.0000 | 2 | 2 |
| alanyl-alanyl-alanine | Homo sapiens (human) | Ki | 180.0000 | 1 | 1 |
| cefuroxime | Homo sapiens (human) | Ki | 19,000.0000 | 2 | 3 |
| ceftriaxone | Homo sapiens (human) | Ki | 30,000.0000 | 2 | 2 |
| cefepime | Homo sapiens (human) | Ki | 30,000.0000 | 2 | 2 |
| hr 810 | Homo sapiens (human) | Ki | 30,000.0000 | 2 | 2 |
| ceftazidime | Homo sapiens (human) | Ki | 10,000.0000 | 1 | 1 |
| alanylalanine | Homo sapiens (human) | IC50 | 156.5000 | 2 | 2 |
| alanylalanine | Homo sapiens (human) | Ki | 772.6667 | 2 | 3 |
| tyrosyl-alanyl-glycine | Homo sapiens (human) | Ki | 14,000.0000 | 1 | 1 |
| phenylalanylalanine | Homo sapiens (human) | IC50 | 35.0900 | 2 | 2 |
| phenylalanylalanine | Homo sapiens (human) | Ki | 73.3933 | 3 | 3 |
| acetylalanylalanine | Homo sapiens (human) | Ki | 30,000.0000 | 1 | 1 |
| alpha-aspartylalanine | Homo sapiens (human) | Ki | 320.0000 | 2 | 2 |
| alanyltyrosine | Homo sapiens (human) | IC50 | 110.0000 | 1 | 1 |
| alanyltyrosine | Homo sapiens (human) | Ki | 90.0000 | 2 | 2 |
| cefotaxime | Homo sapiens (human) | Ki | 30,000.0000 | 2 | 2 |
| cefpodoxime | Homo sapiens (human) | Ki | 30,000.0000 | 1 | 1 |
| prolylglycine | Homo sapiens (human) | IC50 | 16,000.0000 | 1 | 1 |
| prolylglycine | Homo sapiens (human) | Ki | 22,000.0000 | 1 | 1 |
| aspartyllysine | Homo sapiens (human) | Ki | 484.0000 | 2 | 2 |
| arginyllysine | Homo sapiens (human) | IC50 | 8,110.0000 | 1 | 1 |
| methampicillin | Homo sapiens (human) | Ki | 12,850.0000 | 2 | 2 |
| phenylalanylglycine | Homo sapiens (human) | IC50 | 85.1000 | 2 | 2 |
| phenylalanylglycine | Homo sapiens (human) | Ki | 0.2000 | 1 | 1 |
| glutamylalanine | Homo sapiens (human) | Ki | 250.0000 | 2 | 2 |
| phenylalanylphenylalanine | Homo sapiens (human) | Ki | 110.0000 | 2 | 2 |
| histidylhistidine | Homo sapiens (human) | IC50 | 400.0000 | 1 | 1 |
| phenylalanyl-valine | Homo sapiens (human) | Ki | 50.0000 | 2 | 2 |
| alanylglycine | Homo sapiens (human) | Ki | 3,720.0000 | 2 | 2 |
| valyltyrosine | Homo sapiens (human) | Ki | 100.0000 | 2 | 2 |
| lysylglutamic acid | Homo sapiens (human) | IC50 | 820.0000 | 1 | 1 |
| lysylglutamic acid | Homo sapiens (human) | Ki | 1,300.0000 | 1 | 1 |
| Ala-Lys | Homo sapiens (human) | IC50 | 280.0000 | 1 | 1 |
| Ala-Lys | Homo sapiens (human) | Ki | 163.5000 | 2 | 2 |
| valyl-valyl-valine | Homo sapiens (human) | IC50 | 230.0000 | 1 | 1 |
| phenylalanylproline | Homo sapiens (human) | Ki | 130.0000 | 1 | 1 |
| lysylglycine | Homo sapiens (human) | IC50 | 380.0000 | 1 | 1 |
| glycylhistidine | Homo sapiens (human) | IC50 | 810.0000 | 1 | 1 |
| glycylhistidine | Homo sapiens (human) | Ki | 2,033.3333 | 2 | 3 |
| isoleucyl-tyrosine | Homo sapiens (human) | Ki | 120.0000 | 1 | 1 |
| prolyl-serine | Homo sapiens (human) | IC50 | 16,000.0000 | 1 | 1 |
| prolyl-serine | Homo sapiens (human) | Ki | 14,000.0000 | 1 | 1 |
| jbp 485 | Homo sapiens (human) | IC50 | 18,200.0000 | 1 | 1 |
| jbp 485 | Homo sapiens (human) | Ki | 36,000.0000 | 1 | 1 |
| valyl-prolyl-proline | Homo sapiens (human) | Ki | 100.0000 | 1 | 1 |
| prolylvaline | Homo sapiens (human) | Ki | 60.0000 | 1 | 1 |
| isoleucyl-prolyl-proline | Homo sapiens (human) | Ki | 280.0000 | 1 | 1 |
| isoleucyl-valyl-tyrosine | Homo sapiens (human) | Ki | 200.0000 | 1 | 1 |
| prolyl-proline | Homo sapiens (human) | IC50 | 800.0000 | 1 | 1 |
| prolyl-proline | Homo sapiens (human) | Ki | 1,200.0000 | 1 | 1 |
| valacyclovir | Homo sapiens (human) | IC50 | 1,350.2000 | 5 | 5 |
| valacyclovir | Homo sapiens (human) | Ki | 1,770.0000 | 3 | 3 |
Drugs with Activation Measurements
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| glycylsarcosine | Homo sapiens (human) | Km | 977.7778 | 9 | 9 |
| jbp 485 | Homo sapiens (human) | Km | 2,530.0000 | 1 | 1 |
| valtrex | Homo sapiens (human) | Km | 4,825.0000 | 4 | 4 |
| valacyclovir | Homo sapiens (human) | Km | 4,021.5000 | 8 | 8 |
Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1.Journal of medicinal chemistry, , Jun-30, Volume: 48, Issue:13, 2005
Interaction of 31 beta-lactam antibiotics with the H+/peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, , Volume: 59, Issue:1, 2005
Human dipeptide transporter, hPEPT1, stably transfected into Chinese hamster ovary cells.Pharmaceutical research, , Volume: 13, Issue:11, 1996
Human PEPT1 pharmacophore distinguishes between dipeptide transport and binding.Journal of medicinal chemistry, , Jun-15, Volume: 49, Issue:12, 2006
Human dipeptide transporter, hPEPT1, stably transfected into Chinese hamster ovary cells.Pharmaceutical research, , Volume: 13, Issue:11, 1996
Human PEPT1 pharmacophore distinguishes between dipeptide transport and binding.Journal of medicinal chemistry, , Jun-15, Volume: 49, Issue:12, 2006
Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1.Journal of medicinal chemistry, , Jun-30, Volume: 48, Issue:13, 2005
Three-dimensional quantitative structure-activity relationship analyses of peptide substrates of the mammalian H+/peptide cotransporter PEPT1.Journal of medicinal chemistry, , Dec-18, Volume: 46, Issue:26, 2003
Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1.Journal of medicinal chemistry, , Jun-30, Volume: 48, Issue:13, 2005
Interaction of 31 beta-lactam antibiotics with the H+/peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, , Volume: 59, Issue:1, 2005
Differential recognition of beta -lactam antibiotics by intestinal and renal peptide transporters, PEPT 1 and PEPT 2.The Journal of biological chemistry, , Oct-27, Volume: 270, Issue:43, 1995
Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1.Journal of medicinal chemistry, , Jun-30, Volume: 48, Issue:13, 2005
Interaction of 31 beta-lactam antibiotics with the H+/peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, , Volume: 59, Issue:1, 2005
CHO/hPEPT1 cells overexpressing the human peptide transporter (hPEPT1) as an alternative in vitro model for peptidomimetic drugs.Journal of pharmaceutical sciences, , Volume: 88, Issue:3, 1999
Human dipeptide transporter, hPEPT1, stably transfected into Chinese hamster ovary cells.Pharmaceutical research, , Volume: 13, Issue:11, 1996
Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1.Journal of medicinal chemistry, , Jun-30, Volume: 48, Issue:13, 2005
Interaction of 31 beta-lactam antibiotics with the H+/peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, , Volume: 59, Issue:1, 2005
CHO/hPEPT1 cells overexpressing the human peptide transporter (hPEPT1) as an alternative in vitro model for peptidomimetic drugs.Journal of pharmaceutical sciences, , Volume: 88, Issue:3, 1999
5'-Amino acid esters of antiviral nucleosides, acyclovir, and AZT are absorbed by the intestinal PEPT1 peptide transporter.Pharmaceutical research, , Volume: 15, Issue:8, 1998
Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1.Journal of medicinal chemistry, , Jun-30, Volume: 48, Issue:13, 2005
Interaction of 31 beta-lactam antibiotics with the H+/peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, , Volume: 59, Issue:1, 2005
Interactions of a nonpeptidic drug, valacyclovir, with the human intestinal peptide transporter (hPEPT1) expressed in a mammalian cell line.The Journal of pharmacology and experimental therapeutics, , Volume: 289, Issue:1, 1999
Transport characteristics of differently charged cephalosporin antibiotics in oocytes expressing the cloned intestinal peptide transporter PepT1 and in human intestinal Caco-2 cells.The Journal of pharmacology and experimental therapeutics, , Volume: 277, Issue:2, 1996
Differential recognition of beta -lactam antibiotics by intestinal and renal peptide transporters, PEPT 1 and PEPT 2.The Journal of biological chemistry, , Oct-27, Volume: 270, Issue:43, 1995
Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1.Journal of medicinal chemistry, , Jun-30, Volume: 48, Issue:13, 2005
Interaction of 31 beta-lactam antibiotics with the H+/peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, , Volume: 59, Issue:1, 2005
CHO/hPEPT1 cells overexpressing the human peptide transporter (hPEPT1) as an alternative in vitro model for peptidomimetic drugs.Journal of pharmaceutical sciences, , Volume: 88, Issue:3, 1999
Human PEPT1 pharmacophore distinguishes between dipeptide transport and binding.Journal of medicinal chemistry, , Jun-15, Volume: 49, Issue:12, 2006
Three-dimensional quantitative structure-activity relationship analyses of peptide substrates of the mammalian H+/peptide cotransporter PEPT1.Journal of medicinal chemistry, , Dec-18, Volume: 46, Issue:26, 2003
Human PEPT1 pharmacophore distinguishes between dipeptide transport and binding.Journal of medicinal chemistry, , Jun-15, Volume: 49, Issue:12, 2006
Three-dimensional quantitative structure-activity relationship analyses of peptide substrates of the mammalian H+/peptide cotransporter PEPT1.Journal of medicinal chemistry, , Dec-18, Volume: 46, Issue:26, 2003
Species-dependent uptake of glycylsarcosine but not oseltamivir in Pichia pastoris expressing the rat, mouse, and human intestinal peptide transporter PEPT1.Drug metabolism and disposition: the biological fate of chemicals, , Volume: 40, Issue:7, 2012
Human PEPT1 pharmacophore distinguishes between dipeptide transport and binding.Journal of medicinal chemistry, , Jun-15, Volume: 49, Issue:12, 2006
Three-dimensional quantitative structure-activity relationship analyses of peptide substrates of the mammalian H+/peptide cotransporter PEPT1.Journal of medicinal chemistry, , Dec-18, Volume: 46, Issue:26, 2003
Effects of tacrolimus and cyclosporin A on peptide transporter PEPT1 in Caco-2 cells.Pharmaceutical research, , Volume: 18, Issue:5, 2001
Interactions of a nonpeptidic drug, valacyclovir, with the human intestinal peptide transporter (hPEPT1) expressed in a mammalian cell line.The Journal of pharmacology and experimental therapeutics, , Volume: 289, Issue:1, 1999
CHO/hPEPT1 cells overexpressing the human peptide transporter (hPEPT1) as an alternative in vitro model for peptidomimetic drugs.Journal of pharmaceutical sciences, , Volume: 88, Issue:3, 1999
Valacyclovir: a substrate for the intestinal and renal peptide transporters PEPT1 and PEPT2.Biochemical and biophysical research communications, , May-19, Volume: 246, Issue:2, 1998
Cellular uptake mechanism of amino acid ester prodrugs in Caco-2/hPEPT1 cells overexpressing a human peptide transporter.Pharmaceutical research, , Volume: 15, Issue:9, 1998
Human intestinal H+/peptide cotransporter. Cloning, functional expression, and chromosomal localization.The Journal of biological chemistry, , Mar-24, Volume: 270, Issue:12, 1995
Human PEPT1 pharmacophore distinguishes between dipeptide transport and binding.Journal of medicinal chemistry, , Jun-15, Volume: 49, Issue:12, 2006
Three-dimensional quantitative structure-activity relationship analyses of peptide substrates of the mammalian H+/peptide cotransporter PEPT1.Journal of medicinal chemistry, , Dec-18, Volume: 46, Issue:26, 2003
Human PEPT1 pharmacophore distinguishes between dipeptide transport and binding.Journal of medicinal chemistry, , Jun-15, Volume: 49, Issue:12, 2006
Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1.Journal of medicinal chemistry, , Jun-30, Volume: 48, Issue:13, 2005
Three-dimensional quantitative structure-activity relationship analyses of peptide substrates of the mammalian H+/peptide cotransporter PEPT1.Journal of medicinal chemistry, , Dec-18, Volume: 46, Issue:26, 2003
Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1.Journal of medicinal chemistry, , Jun-30, Volume: 48, Issue:13, 2005
Three-dimensional quantitative structure-activity relationship analyses of peptide substrates of the mammalian H+/peptide cotransporter PEPT1.Journal of medicinal chemistry, , Dec-18, Volume: 46, Issue:26, 2003
Human PEPT1 pharmacophore distinguishes between dipeptide transport and binding.Journal of medicinal chemistry, , Jun-15, Volume: 49, Issue:12, 2006
Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1.Journal of medicinal chemistry, , Jun-30, Volume: 48, Issue:13, 2005
Three-dimensional quantitative structure-activity relationship analyses of peptide substrates of the mammalian H+/peptide cotransporter PEPT1.Journal of medicinal chemistry, , Dec-18, Volume: 46, Issue:26, 2003
Human PEPT1 pharmacophore distinguishes between dipeptide transport and binding.Journal of medicinal chemistry, , Jun-15, Volume: 49, Issue:12, 2006
Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1.Journal of medicinal chemistry, , Jun-30, Volume: 48, Issue:13, 2005
Three-dimensional quantitative structure-activity relationship analyses of peptide substrates of the mammalian H+/peptide cotransporter PEPT1.Journal of medicinal chemistry, , Dec-18, Volume: 46, Issue:26, 2003
Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1.Journal of medicinal chemistry, , Jun-30, Volume: 48, Issue:13, 2005
Interaction of 31 beta-lactam antibiotics with the H+/peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, , Volume: 59, Issue:1, 2005
Interaction of anionic cephalosporins with the intestinal and renal peptide transporters PEPT 1 and PEPT 2.Biochimica et biophysica acta, , Mar-13, Volume: 1324, Issue:2, 1997
Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1.Journal of medicinal chemistry, , Jun-30, Volume: 48, Issue:13, 2005
Interaction of 31 beta-lactam antibiotics with the H+/peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, , Volume: 59, Issue:1, 2005
Interaction of anionic cephalosporins with the intestinal and renal peptide transporters PEPT 1 and PEPT 2.Biochimica et biophysica acta, , Mar-13, Volume: 1324, Issue:2, 1997
Transport characteristics of differently charged cephalosporin antibiotics in oocytes expressing the cloned intestinal peptide transporter PepT1 and in human intestinal Caco-2 cells.The Journal of pharmacology and experimental therapeutics, , Volume: 277, Issue:2, 1996
CHO/hPEPT1 cells overexpressing the human peptide transporter (hPEPT1) as an alternative in vitro model for peptidomimetic drugs.Journal of pharmaceutical sciences, , Volume: 88, Issue:3, 1999
5'-Amino acid esters of antiviral nucleosides, acyclovir, and AZT are absorbed by the intestinal PEPT1 peptide transporter.Pharmaceutical research, , Volume: 15, Issue:8, 1998
Human PEPT1 pharmacophore distinguishes between dipeptide transport and binding.Journal of medicinal chemistry, , Jun-15, Volume: 49, Issue:12, 2006
Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1.Journal of medicinal chemistry, , Jun-30, Volume: 48, Issue:13, 2005
Human dipeptide transporter, hPEPT1, stably transfected into Chinese hamster ovary cells.Pharmaceutical research, , Volume: 13, Issue:11, 1996
Proton/peptide cotransporter (PEPT 2) from human kidney: functional characterization and chromosomal localization.Biochimica et biophysica acta, , Nov-22, Volume: 1240, Issue:1, 1995
Human PEPT1 pharmacophore distinguishes between dipeptide transport and binding.Journal of medicinal chemistry, , Jun-15, Volume: 49, Issue:12, 2006
Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1.Journal of medicinal chemistry, , Jun-30, Volume: 48, Issue:13, 2005
Phe-Gly dipeptidomimetics designed for the di-/tripeptide transporters PEPT1 and PEPT2: synthesis and biological investigations.Journal of medicinal chemistry, , Feb-12, Volume: 47, Issue:4, 2004
Three-dimensional quantitative structure-activity relationship analyses of peptide substrates of the mammalian H+/peptide cotransporter PEPT1.Journal of medicinal chemistry, , Dec-18, Volume: 46, Issue:26, 2003
Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1.Journal of medicinal chemistry, , Jun-30, Volume: 48, Issue:13, 2005
Three-dimensional quantitative structure-activity relationship analyses of peptide substrates of the mammalian H+/peptide cotransporter PEPT1.Journal of medicinal chemistry, , Dec-18, Volume: 46, Issue:26, 2003
Human PEPT1 pharmacophore distinguishes between dipeptide transport and binding.Journal of medicinal chemistry, , Jun-15, Volume: 49, Issue:12, 2006
Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1.Journal of medicinal chemistry, , Jun-30, Volume: 48, Issue:13, 2005
Three-dimensional quantitative structure-activity relationship analyses of peptide substrates of the mammalian H+/peptide cotransporter PEPT1.Journal of medicinal chemistry, , Dec-18, Volume: 46, Issue:26, 2003
Human PEPT1 pharmacophore distinguishes between dipeptide transport and binding.Journal of medicinal chemistry, , Jun-15, Volume: 49, Issue:12, 2006
Three-dimensional quantitative structure-activity relationship analyses of peptide substrates of the mammalian H+/peptide cotransporter PEPT1.Journal of medicinal chemistry, , Dec-18, Volume: 46, Issue:26, 2003
Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1.Journal of medicinal chemistry, , Jun-30, Volume: 48, Issue:13, 2005
Proton/peptide cotransporter (PEPT 2) from human kidney: functional characterization and chromosomal localization.Biochimica et biophysica acta, , Nov-22, Volume: 1240, Issue:1, 1995
Human PEPT1 pharmacophore distinguishes between dipeptide transport and binding.Journal of medicinal chemistry, , Jun-15, Volume: 49, Issue:12, 2006
Phe-Gly dipeptidomimetics designed for the di-/tripeptide transporters PEPT1 and PEPT2: synthesis and biological investigations.Journal of medicinal chemistry, , Feb-12, Volume: 47, Issue:4, 2004
Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1.Journal of medicinal chemistry, , Jun-30, Volume: 48, Issue:13, 2005
Three-dimensional quantitative structure-activity relationship analyses of peptide substrates of the mammalian H+/peptide cotransporter PEPT1.Journal of medicinal chemistry, , Dec-18, Volume: 46, Issue:26, 2003
Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1.Journal of medicinal chemistry, , Jun-30, Volume: 48, Issue:13, 2005
Three-dimensional quantitative structure-activity relationship analyses of peptide substrates of the mammalian H+/peptide cotransporter PEPT1.Journal of medicinal chemistry, , Dec-18, Volume: 46, Issue:26, 2003
Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1.Journal of medicinal chemistry, , Jun-30, Volume: 48, Issue:13, 2005
Three-dimensional quantitative structure-activity relationship analyses of peptide substrates of the mammalian H+/peptide cotransporter PEPT1.Journal of medicinal chemistry, , Dec-18, Volume: 46, Issue:26, 2003
Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1.Journal of medicinal chemistry, , Jun-30, Volume: 48, Issue:13, 2005
Three-dimensional quantitative structure-activity relationship analyses of peptide substrates of the mammalian H+/peptide cotransporter PEPT1.Journal of medicinal chemistry, , Dec-18, Volume: 46, Issue:26, 2003
Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1.Journal of medicinal chemistry, , Jun-30, Volume: 48, Issue:13, 2005
Three-dimensional quantitative structure-activity relationship analyses of peptide substrates of the mammalian H+/peptide cotransporter PEPT1.Journal of medicinal chemistry, , Dec-18, Volume: 46, Issue:26, 2003
Human PEPT1 pharmacophore distinguishes between dipeptide transport and binding.Journal of medicinal chemistry, , Jun-15, Volume: 49, Issue:12, 2006
Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1.Journal of medicinal chemistry, , Jun-30, Volume: 48, Issue:13, 2005
Human PEPT1 pharmacophore distinguishes between dipeptide transport and binding.Journal of medicinal chemistry, , Jun-15, Volume: 49, Issue:12, 2006
Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1.Journal of medicinal chemistry, , Jun-30, Volume: 48, Issue:13, 2005
Proton/peptide cotransporter (PEPT 2) from human kidney: functional characterization and chromosomal localization.Biochimica et biophysica acta, , Nov-22, Volume: 1240, Issue:1, 1995
Human PEPT1 pharmacophore distinguishes between dipeptide transport and binding.Journal of medicinal chemistry, , Jun-15, Volume: 49, Issue:12, 2006
Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1.Journal of medicinal chemistry, , Jun-30, Volume: 48, Issue:13, 2005
Three-dimensional quantitative structure-activity relationship analyses of peptide substrates of the mammalian H+/peptide cotransporter PEPT1.Journal of medicinal chemistry, , Dec-18, Volume: 46, Issue:26, 2003
Human PEPT1 pharmacophore distinguishes between dipeptide transport and binding.Journal of medicinal chemistry, , Jun-15, Volume: 49, Issue:12, 2006
Three-dimensional quantitative structure-activity relationship analyses of peptide substrates of the mammalian H+/peptide cotransporter PEPT1.Journal of medicinal chemistry, , Dec-18, Volume: 46, Issue:26, 2003
Human PEPT1 pharmacophore distinguishes between dipeptide transport and binding.Journal of medicinal chemistry, , Jun-15, Volume: 49, Issue:12, 2006
Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1.Journal of medicinal chemistry, , Jun-30, Volume: 48, Issue:13, 2005
Enhancing the intestinal absorption of molecules containing the polar guanidino functionality: a double-targeted prodrug approach.Journal of medicinal chemistry, , Jan-28, Volume: 53, Issue:2, 2010
Amino acid ester prodrugs of the antiviral agent 2-bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole as potential substrates of hPEPT1 transporter.Journal of medicinal chemistry, , Feb-24, Volume: 48, Issue:4, 2005
Effect of ionization on the variable uptake of valacyclovir via the human intestinal peptide transporter (hPepT1) in CHO cells.Biopharmaceutics & drug disposition, , Volume: 21, Issue:5, 2000
Interactions of a nonpeptidic drug, valacyclovir, with the human intestinal peptide transporter (hPEPT1) expressed in a mammalian cell line.The Journal of pharmacology and experimental therapeutics, , Volume: 289, Issue:1, 1999
Valacyclovir: a substrate for the intestinal and renal peptide transporters PEPT1 and PEPT2.Biochemical and biophysical research communications, , May-19, Volume: 246, Issue:2, 1998
Direct evidence for peptide transporter (PepT1)-mediated uptake of a nonpeptide prodrug, valacyclovir.Biochemical and biophysical research communications, , Sep-18, Volume: 250, Issue:2, 1998
5'-Amino acid esters of antiviral nucleosides, acyclovir, and AZT are absorbed by the intestinal PEPT1 peptide transporter.Pharmaceutical research, , Volume: 15, Issue:8, 1998
Enables
This protein enables 4 target(s):
| Target | Category | Definition |
|---|
| proton-dependent oligopeptide secondary active transmembrane transporter activity | molecular function | Enables the transfer of a oligopeptide from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by proton movement. [GOC:mtg_transport, OMIM:600544] |
| peptide:proton symporter activity | molecular function | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: peptide(out) + H+(out) = peptide(in) + H+(in), up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by hydrogen ion movement. [GOC:mtg_transport, TC:2.A.17.-.-] |
| tripeptide transmembrane transporter activity | molecular function | Enables the transfer of a tripeptide, a compound containing three amino acids linked together by peptide bonds, from one side of a membrane to the other. [GOC:jl] |
| dipeptide transmembrane transporter activity | molecular function | Enables the transfer of a dipeptide from one side of a membrane to the other. A dipeptide is a combination of two amino acids linked together by a peptide (-CO-NH-) bond. [GOC:mah] |
Located In
This protein is located in 4 target(s):
| Target | Category | Definition |
|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| brush border | cellular component | The dense covering of microvilli on the apical surface of an epithelial cell in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell. [GOC:sl, ISBN:0815316194] |
| membrane | cellular component | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
| apical plasma membrane | cellular component | The region of the plasma membrane located at the apical end of the cell. [GOC:curators] |
Active In
This protein is active in 2 target(s):
| Target | Category | Definition |
|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| apical plasma membrane | cellular component | The region of the plasma membrane located at the apical end of the cell. [GOC:curators] |
Involved In
This protein is involved in 6 target(s):
| Target | Category | Definition |
|---|
| monoatomic ion transport | biological process | The directed movement of a monoatomic ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic ions (also called simple ions) are ions consisting of exactly one atom. [GOC:ai] |
| protein transport | biological process | The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai] |
| peptide transport | biological process | The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai] |
| dipeptide import across plasma membrane | biological process | The directed movement of a dipeptide from outside of a cell, across the plasma membrane and into the cytosol. [PMID:22226946] |
| tripeptide import across plasma membrane | biological process | The directed movement of a tripeptide from outside of a cell, across the plasma membrane and into the cytosol. [PMID:22226946] |
| proton transmembrane transport | biological process | The directed movement of a proton across a membrane. [GO_REF:0000069, GOC:pr, GOC:TermGenie] |