Proteins > Amine oxidase [flavin-containing] B
Page last updated: 2024-08-07 16:52:18
Amine oxidase [flavin-containing] B
An amine oxidase [flavin-containing] B that is encoded in the genome of cow. [OMA:P56560, PRO:DNx]
Synonyms
EC 1.4.3.4;
Monoamine oxidase type B;
MAO-B
Research
Bioassay Publications (30)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 3 (10.00) | 18.7374 |
| 1990's | 12 (40.00) | 18.2507 |
| 2000's | 8 (26.67) | 29.6817 |
| 2010's | 7 (23.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (32)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine | Bos taurus (cattle) | Ki | 2,550.0000 | 2 | 2 |
| moclobemide | Bos taurus (cattle) | IC50 | 6,715.0000 | 3 | 3 |
| moclobemide | Bos taurus (cattle) | Ki | 85.2500 | 5 | 6 |
| clorgyline | Bos taurus (cattle) | IC50 | 2,634.0000 | 4 | 4 |
| clorgyline | Bos taurus (cattle) | Ki | 48.3423 | 5 | 6 |
| dextroamphetamine | Bos taurus (cattle) | Ki | 300.0000 | 1 | 1 |
| isatin | Bos taurus (cattle) | Ki | 6.1250 | 1 | 4 |
| methamphetamine | Bos taurus (cattle) | Ki | 550.0000 | 1 | 1 |
| 1-acetylisatin | Bos taurus (cattle) | IC50 | 380.0000 | 1 | 1 |
| vinblastine | Bos taurus (cattle) | Ki | 77.0000 | 2 | 2 |
| n,n-dimethylphenylethylamine | Bos taurus (cattle) | Ki | 7,100.0000 | 1 | 1 |
| selegiline | Bos taurus (cattle) | IC50 | 1.0000 | 2 | 2 |
| selegiline | Bos taurus (cattle) | Ki | 1.4417 | 5 | 6 |
| l-amphetamine | Bos taurus (cattle) | Ki | 380.0000 | 1 | 1 |
| toloxatone | Bos taurus (cattle) | IC50 | 15.1356 | 2 | 2 |
| toloxatone | Bos taurus (cattle) | Ki | 15.0000 | 2 | 2 |
| milacemide | Bos taurus (cattle) | Ki | 1,010.0000 | 2 | 2 |
| befloxatone | Bos taurus (cattle) | Ki | 0.2200 | 1 | 1 |
| 1-phenethylamine, (s)-isomer | Bos taurus (cattle) | Ki | 520.0000 | 1 | 1 |
| 2-methyltryptoline | Bos taurus (cattle) | Ki | 400.0000 | 1 | 1 |
| n-propyl-4-phenyl-1,2,3,6-tetrahydropyridine | Bos taurus (cattle) | Ki | 5,000.0000 | 1 | 1 |
| md 780236 | Bos taurus (cattle) | Ki | 200.0000 | 1 | 1 |
| farnesol | Bos taurus (cattle) | Ki | 430.0714 | 1 | 7 |
| 1-phenethylamine, (r)-isomer | Bos taurus (cattle) | Ki | 190.0000 | 1 | 1 |
| rasagiline | Bos taurus (cattle) | Ki | 0.5000 | 1 | 1 |
| quercetin | Bos taurus (cattle) | IC50 | 20.0000 | 1 | 1 |
| genistein | Bos taurus (cattle) | IC50 | 95.0000 | 1 | 1 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| phenethylamine | Bos taurus (cattle) | Km | 2,200.0000 | 1 | 2 |
| 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine | Bos taurus (cattle) | Km | 325.1667 | 6 | 6 |
| benzylamine | Bos taurus (cattle) | Km | 290.0000 | 2 | 2 |
| kynuramine | Bos taurus (cattle) | Km | 84.0000 | 1 | 1 |
| 3-phenylpropylamine | Bos taurus (cattle) | Km | 290.0000 | 1 | 2 |
| phenyl-2-aminoethyl sulfide | Bos taurus (cattle) | Km | 55.0000 | 1 | 2 |
| 1-methyl-4-(4-chlorophenyl)-1,2,3,6-tetrahydropyridine | Bos taurus (cattle) | Km | 190.0000 | 1 | 2 |
| 4-s-cysteaminylphenol | Bos taurus (cattle) | Km | 49.0000 | 1 | 2 |
| 1-methyl-4-(methylpyrrol-2-yl)-1,2,3,6-tetrahydropyridine | Bos taurus (cattle) | Km | 200.0000 | 1 | 1 |
| 4-benzyl-1-methyl-1,2,3,6-tetrahydropyridine | Bos taurus (cattle) | Km | 142.7500 | 4 | 4 |
Studies on the monoamine oxidase-B-catalyzed biotransformation of 4-azaaryl-1-methyl-1,2,3,6-tetrahydropyridine derivatives.Journal of medicinal chemistry, , May-20, Volume: 42, Issue:10, 1999
Assessment of structural requirements for the monoamine oxidase-B-catalyzed oxidation of 1,4-disubstituted-1,2,3,6-tetrahydropyridine derivatives related to the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.Journal of medicinal chemistry, , Sep-13, Volume: 39, Issue:19, 1996
Studies on the monoamine oxidase (MAO)-catalyzed oxidation of phenyl-substituted 1-methyl-4-phenoxy-1,2,3,6-tetrahydropyridine derivatives: factors contributing to MAO-A and MAO-B selectivity.Journal of medicinal chemistry, , May-26, Volume: 38, Issue:11, 1995
Novel 4-(aryloxy)tetrahydropyridine analogs of MPTP as monoamine oxidase A and B substrates.Journal of medicinal chemistry, , Apr-01, Volume: 37, Issue:7, 1994
Molecular size and flexibility as determinants of selectivity in the oxidation of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine analogs by monoamine oxidase A and B.Journal of medicinal chemistry, , Apr-30, Volume: 36, Issue:9, 1993
Synthesis of novel MPTP analogs as potential monoamine oxidase B (MAO-B) inhibitors.Journal of medicinal chemistry, , Oct-30, Volume: 35, Issue:22, 1992
Design, synthesis, and biological evaluation of novel 4-substituted 1-methyl-1,2,3,6-tetrahydropyridine analogs of MPTP.Journal of medicinal chemistry, , Nov-13, Volume: 35, Issue:23, 1992
Studies on semirigid tricyclic analogues of the nigrostriatal toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.Journal of medicinal chemistry, , Volume: 32, Issue:2, 1989
Exploring new selective 3-benzylquinoxaline-based MAO-A inhibitors: design, synthesis, biological evaluation and docking studies.European journal of medicinal chemistry, , Mar-26, Volume: 93, 2015
Synthesis of new 7-oxycoumarin derivatives as potent and selective monoamine oxidase A inhibitors.Journal of medicinal chemistry, , Dec-13, Volume: 55, Issue:23, 2012
Synthesis, structure-activity relationships and molecular modeling studies of new indole inhibitors of monoamine oxidases A and B.Bioorganic & medicinal chemistry, , Nov-15, Volume: 16, Issue:22, 2008
Synthesis, molecular modeling studies and selective inhibitory activity against MAO of N1-propanoyl-3,5-diphenyl-4,5-dihydro-(1H)-pyrazole derivatives.European journal of medicinal chemistry, , Volume: 43, Issue:10, 2008
Monoamine oxidase isoform-dependent tautomeric influence in the recognition of 3,5-diaryl pyrazole inhibitors.Journal of medicinal chemistry, , Feb-08, Volume: 50, Issue:3, 2007
New pyrrole inhibitors of monoamine oxidase: synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B selectivity.Journal of medicinal chemistry, , Mar-08, Volume: 50, Issue:5, 2007
Simple, potent, and selective pyrrole inhibitors of monoamine oxidase types A and B.Journal of medicinal chemistry, , Mar-13, Volume: 46, Issue:6, 2003
Exploring new selective 3-benzylquinoxaline-based MAO-A inhibitors: design, synthesis, biological evaluation and docking studies.European journal of medicinal chemistry, , Mar-26, Volume: 93, 2015
Synthesis, biological investigation and molecular docking study of N-malonyl-1,2-dihydroisoquinoline derivatives as brain specific and shelf-stable MAO inhibitors.European journal of medicinal chemistry, , Mar-26, Volume: 93, 2015
α-Ketoamino acid ester derivatives as promising MAO inhibitors.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 25, Issue:1, 2015
Synthesis and evaluation of quinazoline amino acid derivatives as mono amine oxidase (MAO) inhibitors.Bioorganic & medicinal chemistry, , Jul-01, Volume: 23, Issue:13, 2015
Synthesis of new 7-oxycoumarin derivatives as potent and selective monoamine oxidase A inhibitors.Journal of medicinal chemistry, , Dec-13, Volume: 55, Issue:23, 2012
Synthesis, structure-activity relationships and molecular modeling studies of new indole inhibitors of monoamine oxidases A and B.Bioorganic & medicinal chemistry, , Nov-15, Volume: 16, Issue:22, 2008
New pyrrole inhibitors of monoamine oxidase: synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B selectivity.Journal of medicinal chemistry, , Mar-08, Volume: 50, Issue:5, 2007
Simple, potent, and selective pyrrole inhibitors of monoamine oxidase types A and B.Journal of medicinal chemistry, , Mar-13, Volume: 46, Issue:6, 2003
Novel 4-(aryloxy)tetrahydropyridine analogs of MPTP as monoamine oxidase A and B substrates.Journal of medicinal chemistry, , Apr-01, Volume: 37, Issue:7, 1994
Molecular size and flexibility as determinants of selectivity in the oxidation of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine analogs by monoamine oxidase A and B.Journal of medicinal chemistry, , Apr-30, Volume: 36, Issue:9, 1993
Synthesis of new 7-oxycoumarin derivatives as potent and selective monoamine oxidase A inhibitors.Journal of medicinal chemistry, , Dec-13, Volume: 55, Issue:23, 2012
Synthesis, structure-activity relationships and molecular modeling studies of new indole inhibitors of monoamine oxidases A and B.Bioorganic & medicinal chemistry, , Nov-15, Volume: 16, Issue:22, 2008
Synthesis, molecular modeling studies and selective inhibitory activity against MAO of N1-propanoyl-3,5-diphenyl-4,5-dihydro-(1H)-pyrazole derivatives.European journal of medicinal chemistry, , Volume: 43, Issue:10, 2008
New pyrrole inhibitors of monoamine oxidase: synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B selectivity.Journal of medicinal chemistry, , Mar-08, Volume: 50, Issue:5, 2007
Monoamine oxidase isoform-dependent tautomeric influence in the recognition of 3,5-diaryl pyrazole inhibitors.Journal of medicinal chemistry, , Feb-08, Volume: 50, Issue:3, 2007
Simple, potent, and selective pyrrole inhibitors of monoamine oxidase types A and B.Journal of medicinal chemistry, , Mar-13, Volume: 46, Issue:6, 2003
Novel reversible monoamine oxidase A inhibitors: highly potent and selective 3-(1H-pyrrol-3-yl)-2-oxazolidinones.Journal of medicinal chemistry, , Dec-08, Volume: 54, Issue:23, 2011
Synthesis, molecular modeling studies and selective inhibitory activity against MAO of N1-propanoyl-3,5-diphenyl-4,5-dihydro-(1H)-pyrazole derivatives.European journal of medicinal chemistry, , Volume: 43, Issue:10, 2008
Monoamine oxidase isoform-dependent tautomeric influence in the recognition of 3,5-diaryl pyrazole inhibitors.Journal of medicinal chemistry, , Feb-08, Volume: 50, Issue:3, 2007
3-(1H-Pyrrol-1-yl)-2-oxazolidinones as reversible, highly potent, and selective inhibitors of monoamine oxidase type A.Journal of medicinal chemistry, , Mar-14, Volume: 45, Issue:6, 2002
Assessment of structural requirements for the monoamine oxidase-B-catalyzed oxidation of 1,4-disubstituted-1,2,3,6-tetrahydropyridine derivatives related to the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.Journal of medicinal chemistry, , Sep-13, Volume: 39, Issue:19, 1996
Studies on the monoamine oxidase (MAO)-catalyzed oxidation of phenyl-substituted 1-methyl-4-phenoxy-1,2,3,6-tetrahydropyridine derivatives: factors contributing to MAO-A and MAO-B selectivity.Journal of medicinal chemistry, , May-26, Volume: 38, Issue:11, 1995
Novel 4-(aryloxy)tetrahydropyridine analogs of MPTP as monoamine oxidase A and B substrates.Journal of medicinal chemistry, , Apr-01, Volume: 37, Issue:7, 1994
Molecular size and flexibility as determinants of selectivity in the oxidation of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine analogs by monoamine oxidase A and B.Journal of medicinal chemistry, , Apr-30, Volume: 36, Issue:9, 1993
Design, synthesis, and biological evaluation of novel 4-substituted 1-methyl-1,2,3,6-tetrahydropyridine analogs of MPTP.Journal of medicinal chemistry, , Nov-13, Volume: 35, Issue:23, 1992