| Condition | Indicated | Relationship Strength | Studies | Trials |
|---|
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases. | 0 | 6.36 | 37 | 0 |
Endometrioma
An enlarged area of ENDOMETRIOSIS that resembles a tumor. It is usually found in the OVARY. When it is filled with old blood, it is known as a chocolate cyst. | 0 | 2.82 | 2 | 0 |
Endometriosis
A condition in which functional endometrial tissue is present outside the UTERUS. It is often confined to the PELVIS involving the OVARY, the ligaments, cul-de-sac, and the uterovesical peritoneum. | 0 | 2.82 | 2 | 0 |
Carcinoma, Non-Small Cell Lung
[description not available] | 0 | 2.58 | 2 | 0 |
Cancer of Lung
[description not available] | 0 | 6.34 | 8 | 1 |
Carcinoma, Non-Small-Cell Lung
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy. | 0 | 2.58 | 2 | 0 |
Lung Neoplasms
Tumors or cancer of the LUNG. | 0 | 6.34 | 8 | 1 |
Cancer of Liver
[description not available] | 0 | 2.76 | 2 | 0 |
Liver Neoplasms
Tumors or cancer of the LIVER. | 0 | 2.76 | 2 | 0 |
Angiostrongylus Infections
[description not available] | 0 | 2.41 | 1 | 0 |
Carcinoma, Squamous Cell of Head and Neck
[description not available] | 0 | 2.59 | 2 | 0 |
Cancer of Head
[description not available] | 0 | 4.47 | 8 | 0 |
Squamous Cell Carcinoma of Head and Neck
The most common type of head and neck carcinoma that originates from cells on the surface of the NASAL CAVITY; MOUTH; PARANASAL SINUSES, SALIVARY GLANDS, and LARYNX. Mutations in TNFRSF10B, PTEN, and ING1 genes are associated with this cancer. | 0 | 2.59 | 2 | 0 |
Head and Neck Neoplasms
Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651) | 0 | 4.47 | 8 | 0 |
Amyloid Deposits
[description not available] | 0 | 3.44 | 2 | 0 |
Acute Confusional Senile Dementia
[description not available] | 0 | 3.71 | 3 | 0 |
Amyloid Angiopathy, Cerebral
[description not available] | 0 | 2.25 | 1 | 0 |
Alzheimer Disease
A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57) | 0 | 3.71 | 3 | 0 |
Cerebral Amyloid Angiopathy
A heterogeneous group of sporadic or familial disorders characterized by AMYLOID deposits in the walls of small and medium sized blood vessels of CEREBRAL CORTEX and MENINGES. Clinical features include multiple, small lobar CEREBRAL HEMORRHAGE; cerebral ischemia (BRAIN ISCHEMIA); and CEREBRAL INFARCTION. Cerebral amyloid angiopathy is unrelated to generalized AMYLOIDOSIS. Amyloidogenic peptides in this condition are nearly always the same ones found in ALZHEIMER DISEASE. (from Kumar: Robbins and Cotran: Pathologic Basis of Disease, 7th ed., 2005) | 0 | 2.25 | 1 | 0 |
Cerebral Pseudosclerosis
[description not available] | 0 | 14.84 | 76 | 6 |
Hepatolenticular Degeneration
A rare autosomal recessive disease characterized by the deposition of copper in the BRAIN; LIVER; CORNEA; and other organs. It is caused by defects in the ATP7B gene encoding copper-transporting ATPase 2 (EC 3.6.3.4), also known as the Wilson disease protein. The overload of copper inevitably leads to progressive liver and neurological dysfunction such as LIVER CIRRHOSIS; TREMOR; ATAXIA and intellectual deterioration. Hepatic dysfunction may precede neurologic dysfunction by several years. | 0 | 14.84 | 76 | 6 |
Benign Neoplasms
[description not available] | 0 | 9.56 | 23 | 2 |
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms. | 0 | 9.56 | 23 | 2 |
Hepatocellular Carcinoma
[description not available] | 0 | 2.25 | 1 | 0 |
Carcinoma, Hepatocellular
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested. | 0 | 2.25 | 1 | 0 |
Injury, Ischemia-Reperfusion
[description not available] | 0 | 2.15 | 1 | 0 |
Reperfusion Injury
Adverse functional, metabolic, or structural changes in tissues that result from the restoration of blood flow to the tissue (REPERFUSION) following ISCHEMIA. | 0 | 7.15 | 1 | 0 |
Abnormalities, Autosome
[description not available] | 0 | 3.06 | 1 | 0 |
Bone Cancer
[description not available] | 0 | 3.45 | 2 | 0 |
Bone Loss, Osteoclastic
[description not available] | 0 | 2.17 | 1 | 0 |
Carcinoma, Epidermoid
[description not available] | 0 | 4.93 | 8 | 1 |
Invasiveness, Neoplasm
[description not available] | 0 | 2.5 | 2 | 0 |
Bone Neoplasms
Tumors or cancer located in bone tissue or specific BONES. | 0 | 3.45 | 2 | 0 |
Carcinoma, Squamous Cell
A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed) | 0 | 4.93 | 8 | 1 |
Canine Diseases
[description not available] | 0 | 3.45 | 2 | 0 |
Angiosarcoma
[description not available] | 0 | 7.17 | 1 | 0 |
Hemangiosarcoma
A rare malignant neoplasm characterized by rapidly proliferating, extensively infiltrating, anaplastic cells derived from blood vessels and lining irregular blood-filled or lumpy spaces. (Stedman, 25th ed) | 0 | 7.17 | 1 | 0 |
Palmoplantaris Pustulosis
[description not available] | 0 | 2.17 | 1 | 0 |
Psoriasis
A common genetically determined, chronic, inflammatory skin disease characterized by rounded erythematous, dry, scaling patches. The lesions have a predilection for nails, scalp, genitalia, extensor surfaces, and the lumbosacral region. Accelerated epidermopoiesis is considered to be the fundamental pathologic feature in psoriasis. | 0 | 2.17 | 1 | 0 |
ER-Negative PR-Negative HER2-Negative Breast Cancer
[description not available] | 0 | 4.23 | 3 | 1 |
Angiogenesis, Pathologic
[description not available] | 0 | 8.11 | 18 | 1 |
Triple Negative Breast Neoplasms
Breast neoplasms that do not express ESTROGEN RECEPTORS; PROGESTERONE RECEPTORS; and do not overexpress the NEU RECEPTOR/HER-2 PROTO-ONCOGENE PROTEIN. | 0 | 4.23 | 3 | 1 |
Breast Cancer
[description not available] | 0 | 6.42 | 8 | 2 |
Local Neoplasm Recurrence
[description not available] | 0 | 5.08 | 3 | 3 |
Breast Neoplasms
Tumors or cancer of the human BREAST. | 0 | 6.42 | 8 | 2 |
Hematologic Malignancies
[description not available] | 0 | 2.08 | 1 | 0 |
Acute Lymphoid Leukemia
[description not available] | 0 | 2.08 | 1 | 0 |
Hematologic Neoplasms
Neoplasms located in the blood and blood-forming tissue (the bone marrow and lymphatic tissue). The commonest forms are the various types of LEUKEMIA, of LYMPHOMA, and of the progressive, life-threatening forms of the MYELODYSPLASTIC SYNDROMES. | 0 | 2.08 | 1 | 0 |
Precursor Cell Lymphoblastic Leukemia-Lymphoma
A neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and other organs. It is the most common cancer in children and accounts for the vast majority of all childhood leukemias. | 0 | 2.08 | 1 | 0 |
Orphan Diseases
Rare diseases that have not been well studied. | 0 | 3 | 1 | 0 |
Anoxemia
[description not available] | 0 | 2.48 | 2 | 0 |
Hypoxia
Sub-optimal OXYGEN levels in the ambient air of living organisms. | 0 | 2.48 | 2 | 0 |
Neuroblastoma
A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51) | 0 | 2.52 | 2 | 0 |
Cirrhosis, Liver
[description not available] | 0 | 3.67 | 3 | 0 |
Liver Cirrhosis
Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules. | 0 | 3.67 | 3 | 0 |
Chromosomal Instability
An increased tendency to acquire CHROMOSOME ABERRATIONS when various processes involved in chromosome replication, repair, or segregation are dysfunctional. | 0 | 2.08 | 1 | 0 |
Colorectal Cancer
[description not available] | 0 | 9.16 | 3 | 1 |
Colorectal Neoplasms
Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI. | 0 | 4.16 | 3 | 1 |
Innate Inflammatory Response
[description not available] | 0 | 5.26 | 8 | 0 |
Inflammation
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function. | 0 | 10.26 | 8 | 0 |
Diffuse Large B-Cell Lymphoma
[description not available] | 0 | 2.1 | 1 | 0 |
Lymphoma, Large B-Cell, Diffuse
Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. The pattern is predominantly diffuse. Most of these lymphomas represent the malignant counterpart of B-lymphocytes at midstage in the process of differentiation. | 0 | 2.1 | 1 | 0 |
Osteogenic Sarcoma
[description not available] | 0 | 3.89 | 2 | 0 |
Osteosarcoma
A sarcoma originating in bone-forming cells, affecting the ends of long bones. It is the most common and most malignant of sarcomas of the bones, and occurs chiefly among 10- to 25-year-old youths. (From Stedman, 25th ed) | 0 | 3.89 | 2 | 0 |
Alveolitis, Fibrosing
[description not available] | 0 | 4.51 | 5 | 0 |
Pulmonary Fibrosis
A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death. | 0 | 4.51 | 5 | 0 |
Granulocytic Leukemia
[description not available] | 0 | 2.11 | 1 | 0 |
Leukemia, Myeloid
Form of leukemia characterized by an uncontrolled proliferation of the myeloid lineage and their precursors (MYELOID PROGENITOR CELLS) in the bone marrow and other sites. | 0 | 2.11 | 1 | 0 |
Malignant Melanoma
[description not available] | 0 | 2.75 | 3 | 0 |
Melanoma
A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445) | 0 | 2.75 | 3 | 0 |
Cancer of Endometrium
[description not available] | 0 | 2.49 | 2 | 0 |
Endometrial Neoplasms
Tumors or cancer of ENDOMETRIUM, the mucous lining of the UTERUS. These neoplasms can be benign or malignant. Their classification and grading are based on the various cell types and the percent of undifferentiated cells. | 0 | 2.49 | 2 | 0 |
Atherogenesis
[description not available] | 0 | 3.42 | 2 | 0 |
Akinetic-Rigid Variant of Huntington Disease
[description not available] | 0 | 3.4 | 2 | 0 |
Huntington Disease
A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive CHOREA and DEMENTIA in the fourth or fifth decade of life. Common initial manifestations include paranoia; poor impulse control; DEPRESSION; HALLUCINATIONS; and DELUSIONS. Eventually intellectual impairment; loss of fine motor control; ATHETOSIS; and diffuse chorea involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. The juvenile variant has a more fulminant course including SEIZURES; ATAXIA; dementia; and chorea. (From Adams et al., Principles of Neurology, 6th ed, pp1060-4) | 0 | 8.4 | 2 | 0 |
Atherosclerosis
A thickening and loss of elasticity of the walls of ARTERIES that occurs with formation of ATHEROSCLEROTIC PLAQUES within the ARTERIAL INTIMA. | 0 | 3.42 | 2 | 0 |
Disease Exacerbation
[description not available] | 0 | 6.07 | 6 | 5 |
Adenocarcinoma, Basal Cell
[description not available] | 0 | 5.73 | 5 | 4 |
Adenocarcinoma
A malignant epithelial tumor with a glandular organization. | 0 | 5.73 | 5 | 4 |
Neutropenia
A decrease in the number of NEUTROPHILS found in the blood. | 0 | 3.83 | 2 | 1 |
ALS - Amyotrophic Lateral Sclerosis
[description not available] | 0 | 2.46 | 2 | 0 |
Amyotrophic Lateral Sclerosis
A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94) | 0 | 7.46 | 2 | 0 |
Neoplasms, Pleural
[description not available] | 0 | 3.43 | 1 | 1 |
Mesothelioma
A tumor derived from mesothelial tissue (peritoneum, pleura, pericardium). It appears as broad sheets of cells, with some regions containing spindle-shaped, sarcoma-like cells and other regions showing adenomatous patterns. Pleural mesotheliomas have been linked to exposure to asbestos. (Dorland, 27th ed) | 0 | 8.43 | 1 | 1 |
Pregnancy
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. | 0 | 6.16 | 12 | 0 |
Metastase
[description not available] | 0 | 5.43 | 5 | 3 |
Neoplasm Metastasis
The transfer of a neoplasm from one organ or part of the body to another remote from the primary site. | 0 | 5.43 | 5 | 3 |
Allergic Encephalomyelitis
[description not available] | 0 | 2.04 | 1 | 0 |
MS (Multiple Sclerosis)
[description not available] | 0 | 2.04 | 1 | 0 |
Multiple Sclerosis
An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903) | 0 | 7.04 | 1 | 0 |
Disease
A definite pathologic process with a characteristic set of signs and symptoms. It may affect the whole body or any of its parts, and its etiology, pathology, and prognosis may be known or unknown. | 0 | 2.96 | 1 | 0 |
Carbon Tetrachloride Poisoning
Poisoning that results from ingestion, injection, inhalation, or skin absorption of CARBON TETRACHLORIDE. | 0 | 2.44 | 2 | 0 |
Cirrhoses, Experimental Liver
[description not available] | 0 | 2.05 | 1 | 0 |
Diabetes Mellitus, Adult-Onset
[description not available] | 0 | 2.05 | 1 | 0 |
Diabetes Mellitus, Type 2
A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY. | 0 | 2.05 | 1 | 0 |
Absence Seizure
[description not available] | 0 | 2.05 | 1 | 0 |
Absence Status
[description not available] | 0 | 2.05 | 1 | 0 |
Seizures
Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder. | 0 | 2.05 | 1 | 0 |
Status Epilepticus
A prolonged seizure or seizures repeated frequently enough to prevent recovery between episodes occurring over a period of 20-30 minutes. The most common subtype is generalized tonic-clonic status epilepticus, a potentially fatal condition associated with neuronal injury and respiratory and metabolic dysfunction. Nonconvulsive forms include petit mal status and complex partial status, which may manifest as behavioral disturbances. Simple partial status epilepticus consists of persistent motor, sensory, or autonomic seizures that do not impair cognition (see also EPILEPSIA PARTIALIS CONTINUA). Subclinical status epilepticus generally refers to seizures occurring in an unresponsive or comatose individual in the absence of overt signs of seizure activity. (From N Engl J Med 1998 Apr 2;338(14):970-6; Neurologia 1997 Dec;12 Suppl 6:25-30) | 0 | 2.05 | 1 | 0 |
Carcinoma, Anaplastic
[description not available] | 0 | 2.05 | 1 | 0 |
Animal Mammary Carcinoma
[description not available] | 0 | 2.05 | 1 | 0 |
Carcinoma
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for cancer. | 0 | 7.05 | 1 | 0 |
Biliary Cirrhosis
[description not available] | 0 | 3.85 | 2 | 1 |
Liver Cirrhosis, Biliary
FIBROSIS of the hepatic parenchyma due to obstruction of BILE flow (CHOLESTASIS) in the intrahepatic or extrahepatic bile ducts (BILE DUCTS, INTRAHEPATIC; BILE DUCTS, EXTRAHEPATIC). Primary biliary cholangitis involves the destruction of small intra-hepatic bile ducts and decreased bile secretion. Secondary biliary cholangitis is produced by prolonged obstruction of large intrahepatic or extrahepatic bile ducts from a variety of causes. | 0 | 3.85 | 2 | 1 |
Cancer of Cervix
[description not available] | 0 | 2.05 | 1 | 0 |
Cancer of Ovary
[description not available] | 0 | 2.47 | 2 | 0 |
Uterine Cervical Neoplasms
Tumors or cancer of the UTERINE CERVIX. | 0 | 2.05 | 1 | 0 |
Ovarian Neoplasms
Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS. | 0 | 2.47 | 2 | 0 |
Age-Related Memory Disorders
[description not available] | 0 | 2.05 | 1 | 0 |
Memory Disorders
Disturbances in registering an impression, in the retention of an acquired impression, or in the recall of an impression. Memory impairments are associated with DEMENTIA; CRANIOCEREBRAL TRAUMA; ENCEPHALITIS; ALCOHOLISM (see also ALCOHOL AMNESTIC DISORDER); SCHIZOPHRENIA; and other conditions. | 0 | 2.05 | 1 | 0 |
Benign Cerebellar Neoplasms
[description not available] | 0 | 2.06 | 1 | 0 |
Arachnoidal Cerebellar Sarcoma, Circumscribed
[description not available] | 0 | 2.06 | 1 | 0 |
Medulloblastoma
A malignant neoplasm that may be classified either as a glioma or as a primitive neuroectodermal tumor of childhood (see NEUROECTODERMAL TUMOR, PRIMITIVE). The tumor occurs most frequently in the first decade of life with the most typical location being the cerebellar vermis. Histologic features include a high degree of cellularity, frequent mitotic figures, and a tendency for the cells to organize into sheets or form rosettes. Medulloblastoma have a high propensity to spread throughout the craniospinal intradural axis. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2060-1) | 0 | 7.06 | 1 | 0 |
Dystonia
An attitude or posture due to the co-contraction of agonists and antagonist muscles in one region of the body. It most often affects the large axial muscles of the trunk and limb girdles. Conditions which feature persistent or recurrent episodes of dystonia as a primary manifestation of disease are referred to as DYSTONIC DISORDERS. (Adams et al., Principles of Neurology, 6th ed, p77) | 0 | 2.06 | 1 | 0 |
Action Tremor
[description not available] | 0 | 2.06 | 1 | 0 |
Tremor
Cyclical movement of a body part that can represent either a physiologic process or a manifestation of disease. Intention or action tremor, a common manifestation of CEREBELLAR DISEASES, is aggravated by movement. In contrast, resting tremor is maximal when there is no attempt at voluntary movement, and occurs as a relatively frequent manifestation of PARKINSON DISEASE. | 0 | 2.06 | 1 | 0 |
Body Weight
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms. | 0 | 2.71 | 3 | 0 |
Chronic Lung Injury
[description not available] | 0 | 2.06 | 1 | 0 |
Bile Duct Obstruction
[description not available] | 0 | 3.62 | 3 | 0 |
Cholestasis
Impairment of bile flow due to obstruction in small bile ducts (INTRAHEPATIC CHOLESTASIS) or obstruction in large bile ducts (EXTRAHEPATIC CHOLESTASIS). | 0 | 3.62 | 3 | 0 |
Lassitude
[description not available] | 0 | 3.47 | 1 | 1 |
Leukocytopenia
[description not available] | 0 | 3.47 | 1 | 1 |
Cancer of Prostate
[description not available] | 0 | 5.6 | 3 | 2 |
Diarrhea
An increased liquidity or decreased consistency of FECES, such as running stool. Fecal consistency is related to the ratio of water-holding capacity of insoluble solids to total water, rather than the amount of water present. Diarrhea is not hyperdefecation or increased fecal weight. | 0 | 3.47 | 1 | 1 |
Fatigue
The state of weariness following a period of exertion, mental or physical, characterized by a decreased capacity for work and reduced efficiency to respond to stimuli. | 0 | 3.47 | 1 | 1 |
Leukopenia
A decrease in the number of LEUKOCYTES in a blood sample below the normal range (LEUKOCYTE COUNT less than 4000). | 0 | 3.47 | 1 | 1 |
Nausea
An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and motion sickness, emotional stress, intense pain, food poisoning, and various enteroviruses. | 0 | 3.47 | 1 | 1 |
Prostatic Neoplasms
Tumors or cancer of the PROSTATE. | 0 | 5.6 | 3 | 2 |
Pulmonary Hypertension
[description not available] | 0 | 2.07 | 1 | 0 |
Hypertension, Pulmonary
Increased VASCULAR RESISTANCE in the PULMONARY CIRCULATION, usually secondary to HEART DISEASES or LUNG DISEASES. | 0 | 2.07 | 1 | 0 |
Diathesis
[description not available] | 0 | 2.07 | 1 | 0 |
Ovine Diseases
[description not available] | 0 | 4.77 | 12 | 0 |
Koch's Disease
[description not available] | 0 | 2.07 | 1 | 0 |
Tuberculosis
Any of the infectious diseases of man and other animals caused by species of MYCOBACTERIUM TUBERCULOSIS. | 0 | 2.07 | 1 | 0 |
Glial Cell Tumors
[description not available] | 0 | 2.07 | 1 | 0 |
Glioma
Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21) | 0 | 2.07 | 1 | 0 |
Aortic Diseases
Pathological processes involving any part of the AORTA. | 0 | 2.07 | 1 | 0 |
Cancer of Esophagus
[description not available] | 0 | 3.47 | 1 | 1 |
Esophageal Neoplasms
Tumors or cancer of the ESOPHAGUS. | 0 | 3.47 | 1 | 1 |
Deficiency Diseases
A condition produced by dietary or metabolic deficiency. The term includes all diseases caused by an insufficient supply of essential nutrients, i.e., protein (or amino acids), vitamins, and minerals. It also includes an inadequacy of calories. (From Dorland, 27th ed; Stedman, 25th ed) | 0 | 2.99 | 1 | 0 |
Infection
[description not available] | 0 | 2.99 | 1 | 0 |
Infections
Invasion of the host organism by microorganisms or their toxins or by parasites that can cause pathological conditions or diseases. | 0 | 2.99 | 1 | 0 |
Bovine Diseases
[description not available] | 0 | 3.63 | 3 | 0 |
Experimental Mammary Neoplasms
[description not available] | 0 | 2.42 | 2 | 0 |
Basal Ganglia Diseases
Diseases of the BASAL GANGLIA including the PUTAMEN; GLOBUS PALLIDUS; claustrum; AMYGDALA; and CAUDATE NUCLEUS. DYSKINESIAS (most notably involuntary movements and alterations of the rate of movement) represent the primary clinical manifestations of these disorders. Common etiologies include CEREBROVASCULAR DISORDERS; NEURODEGENERATIVE DISEASES; and CRANIOCEREBRAL TRAUMA. | 0 | 2.93 | 1 | 0 |
Behavior Disorders
[description not available] | 0 | 2.93 | 1 | 0 |
Chronic Hepatitis
[description not available] | 0 | 2.93 | 1 | 0 |
Complications, Pregnancy
[description not available] | 0 | 3.81 | 2 | 0 |
Mental Disorders
Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of thought, feeling, and behavior producing either distress or impairment of function. | 0 | 2.93 | 1 | 0 |
Hepatitis, Chronic
INFLAMMATION of the LIVER with ongoing hepatocellular injury for 6 months or more, characterized by NECROSIS of HEPATOCYTES and inflammatory cell (LEUKOCYTES) infiltration. Chronic hepatitis can be caused by viruses, medications, autoimmune diseases, and other unknown factors. | 0 | 2.93 | 1 | 0 |
Choroid Neovascularization
[description not available] | 0 | 3.39 | 1 | 1 |
Age-Related Macular Degeneration
[description not available] | 0 | 8.39 | 1 | 1 |
Macular Degeneration
Degenerative changes in the RETINA usually of older adults which results in a loss of vision in the center of the visual field (the MACULA LUTEA) because of damage to the retina. It occurs in dry and wet forms. | 0 | 8.39 | 1 | 1 |
Nervous System Disorders
[description not available] | 0 | 6.13 | 4 | 1 |
Nervous System Diseases
Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, peripheral nerves, nerve roots, autonomic nervous system, neuromuscular junction, and muscle. | 0 | 6.13 | 4 | 1 |
Sterility, Female
[description not available] | 0 | 2.01 | 1 | 0 |
Infertility, Female
Diminished or absent ability of a female to achieve conception. | 0 | 2.01 | 1 | 0 |
Cancer of Kidney
[description not available] | 0 | 3.4 | 1 | 1 |
Kidney Neoplasms
Tumors or cancers of the KIDNEY. | 0 | 3.4 | 1 | 1 |
Corneal Angiogenesis
[description not available] | 0 | 2.93 | 1 | 0 |
Corneal Neovascularization
New blood vessels originating from the corneal blood vessels and extending from the limbus into the adjacent CORNEAL STROMA. Neovascularization in the superficial and/or deep corneal stroma is a sequel to numerous inflammatory diseases of the ocular anterior segment, such as TRACHOMA, viral interstitial KERATITIS, microbial KERATOCONJUNCTIVITIS, and the immune response elicited by CORNEAL TRANSPLANTATION. | 0 | 2.93 | 1 | 0 |
Adenohypophyseal Diseases
[description not available] | 0 | 2.02 | 1 | 0 |
Pituitary Diseases
Disorders involving either the ADENOHYPOPHYSIS or the NEUROHYPOPHYSIS. These diseases usually manifest as hypersecretion or hyposecretion of PITUITARY HORMONES. Neoplastic pituitary masses can also cause compression of the OPTIC CHIASM and other adjacent structures. | 0 | 2.02 | 1 | 0 |
Poisoning
Used with drugs, chemicals, and industrial materials for human or animal poisoning, acute or chronic, whether the poisoning is accidental, occupational, suicidal, by medication error, or by environmental exposure. | 0 | 3.33 | 2 | 0 |
Hepatitis, Animal
INFLAMMATION of the LIVER in non-human animals. | 0 | 2.4 | 2 | 0 |
Acute Disease
Disease having a short and relatively severe course. | 0 | 2.02 | 1 | 0 |
Hospital-Acquired Condition
[description not available] | 0 | 2.02 | 1 | 0 |
Neovascularization, Optic Disc
[description not available] | 0 | 2.02 | 1 | 0 |
Ischemia
A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION. | 0 | 2.02 | 1 | 0 |
Retinal Neovascularization
Formation of new blood vessels originating from the retinal veins and extending along the inner (vitreal) surface of the retina. | 0 | 7.02 | 1 | 0 |
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed) | 0 | 2.02 | 1 | 0 |
Cough
A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation. It is a protective response that serves to clear the trachea, bronchi, and/or lungs of irritants and secretions, or to prevent aspiration of foreign materials into the lungs. | 0 | 2.02 | 1 | 0 |
Cirrhosis
[description not available] | 0 | 3.64 | 3 | 0 |
Fibrosis
Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury. | 0 | 8.64 | 3 | 0 |
Cardiomyopathies, Primary
[description not available] | 0 | 2.02 | 1 | 0 |
Cardiomyopathies
A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classified according to their predominant pathophysiological features (DILATED CARDIOMYOPATHY; HYPERTROPHIC CARDIOMYOPATHY; RESTRICTIVE CARDIOMYOPATHY) or their etiological/pathological factors (CARDIOMYOPATHY, ALCOHOLIC; ENDOCARDIAL FIBROELASTOSIS). | 0 | 2.02 | 1 | 0 |
Adjuvant Arthritis
[description not available] | 0 | 2.43 | 2 | 0 |
Cachexia
General ill health, malnutrition, and weight loss, usually associated with chronic disease. | 0 | 7.02 | 1 | 0 |
Autoimmune Disease
[description not available] | 0 | 7.03 | 1 | 0 |
Autoimmune Diabetes
[description not available] | 0 | 2.03 | 1 | 0 |
Autoimmune Diseases
Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides. | 0 | 7.03 | 1 | 0 |
Diabetes Mellitus, Type 1
A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence. | 0 | 2.03 | 1 | 0 |
Obesity
A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY). | 0 | 2.03 | 1 | 0 |
Aprosodia
[description not available] | 0 | 7.45 | 4 | 4 |
Anemia
A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN. | 0 | 7.45 | 4 | 4 |
Coronary Restenosis
Recurrent narrowing or constriction of a coronary artery following surgical procedures performed to alleviate a prior obstruction. | 0 | 2.03 | 1 | 0 |
Kahler Disease
[description not available] | 0 | 2.03 | 1 | 0 |
Multiple Myeloma
A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY. | 0 | 2.03 | 1 | 0 |
Anasarca
[description not available] | 0 | 2.03 | 1 | 0 |
Edema
Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE. | 0 | 2.03 | 1 | 0 |
Erythema
Redness of the skin produced by congestion of the capillaries. This condition may result from a variety of disease processes. | 0 | 2.03 | 1 | 0 |
Necrosis
The death of cells in an organ or tissue due to disease, injury or failure of the blood supply. | 0 | 7.03 | 1 | 0 |
Carcinoma, Lewis Lung
A carcinoma discovered by Dr. Margaret R. Lewis of the Wistar Institute in 1951. This tumor originated spontaneously as a carcinoma of the lung of a C57BL mouse. The tumor does not appear to be grossly hemorrhagic and the majority of the tumor tissue is a semifirm homogeneous mass. (From Cancer Chemother Rep 2 1972 Nov;(3)1:325) It is also called 3LL and LLC and is used as a transplantable malignancy. | 0 | 2.03 | 1 | 0 |
Cardiac Diseases
[description not available] | 0 | 2.03 | 1 | 0 |
Heart Diseases
Pathological conditions involving the HEART including its structural and functional abnormalities. | 0 | 2.03 | 1 | 0 |
Cell Transformation, Neoplastic
Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill. | 0 | 2.95 | 1 | 0 |
Alloxan Diabetes
[description not available] | 0 | 2.04 | 1 | 0 |
Hyperglycemia, Postprandial
Abnormally high BLOOD GLUCOSE level after a meal. | 0 | 2.04 | 1 | 0 |
Hyperglycemia
Abnormally high BLOOD GLUCOSE level. | 0 | 7.04 | 1 | 0 |
Proteinuria
The presence of proteins in the urine, an indicator of KIDNEY DISEASES. | 0 | 2.04 | 1 | 0 |
Extravascular Hemolysis
[description not available] | 0 | 2.88 | 4 | 0 |
Hemolysis
The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity. | 0 | 2.88 | 4 | 0 |
Chronic Illness
[description not available] | 0 | 2.38 | 2 | 0 |
Chronic Disease
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2). | 0 | 2.38 | 2 | 0 |
Aging
The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time. | 0 | 1.98 | 1 | 0 |
Icterus
[description not available] | 0 | 2.39 | 2 | 0 |
Jaundice
A clinical manifestation of HYPERBILIRUBINEMIA, characterized by the yellowish staining of the SKIN; MUCOUS MEMBRANE; and SCLERA. Clinical jaundice usually is a sign of LIVER dysfunction. | 0 | 2.39 | 2 | 0 |
Hepatitis
INFLAMMATION of the LIVER. | 0 | 2.9 | 1 | 0 |
Brain Disorders
[description not available] | 0 | 1.99 | 1 | 0 |
Corneal Diseases
Diseases of the cornea. | 0 | 2.4 | 2 | 0 |
Brain Diseases
Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This includes (but is not limited to) the CEREBRAL CORTEX; intracranial white matter; BASAL GANGLIA; THALAMUS; HYPOTHALAMUS; BRAIN STEM; and CEREBELLUM. | 0 | 1.99 | 1 | 0 |
Acute Liver Injury, Drug-Induced
[description not available] | 0 | 1.99 | 1 | 0 |
Chemical and Drug Induced Liver Injury
A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment. | 0 | 1.99 | 1 | 0 |
Depression, Endogenous
[description not available] | 0 | 1.99 | 1 | 0 |
Chronic Insomnia
[description not available] | 0 | 1.99 | 1 | 0 |
Developmental Psychomotor Disorders
[description not available] | 0 | 1.99 | 1 | 0 |
Depressive Disorder
An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood disturbance is prominent and relatively persistent. | 0 | 1.99 | 1 | 0 |
Sleep Initiation and Maintenance Disorders
Disorders characterized by impairment of the ability to initiate or maintain sleep. This may occur as a primary disorder or in association with another medical or psychiatric condition. | 0 | 1.99 | 1 | 0 |
Thrombopenia
[description not available] | 0 | 1.99 | 1 | 0 |
Thrombocytopenia
A subnormal level of BLOOD PLATELETS. | 0 | 1.99 | 1 | 0 |
Caprine Diseases
[description not available] | 0 | 2.91 | 1 | 0 |
Benign Neoplasms, Brain
[description not available] | 0 | 2 | 1 | 0 |
Astrocytoma, Grade IV
[description not available] | 0 | 2 | 1 | 0 |
Brain Neoplasms
Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain. | 0 | 2 | 1 | 0 |
Glioblastoma
A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures. | 0 | 2 | 1 | 0 |
Rodent Diseases
Diseases of rodents of the order RODENTIA. This term includes diseases of Sciuridae (squirrels), Geomyidae (gophers), Heteromyidae (pouched mice), Castoridae (beavers), Cricetidae (rats and mice), Muridae (Old World rats and mice), Erethizontidae (porcupines), and Caviidae (guinea pigs). | 0 | 1.95 | 1 | 0 |
Polyarthritis
[description not available] | 0 | 1.98 | 1 | 0 |
Arthritis
Acute or chronic inflammation of JOINTS. | 0 | 1.98 | 1 | 0 |
Liver Dysfunction
[description not available] | 0 | 2.89 | 1 | 0 |
Liver Diseases
Pathological processes of the LIVER. | 0 | 2.89 | 1 | 0 |
Bone Diseases, Developmental
Diseases resulting in abnormal GROWTH or abnormal MORPHOGENESIS of BONES. | 0 | 1.96 | 1 | 0 |
Metal Metabolism, Inborn Error
[description not available] | 0 | 1.96 | 1 | 0 |
Metal Metabolism, Inborn Errors
Dysfunctions in the metabolism of metals resulting from inborn genetic mutations that are inherited or acquired in utero. | 0 | 1.96 | 1 | 0 |
Pancytopenia
Deficiency of all three cell elements of the blood, erythrocytes, leukocytes and platelets. | 0 | 6.96 | 1 | 0 |