diazoxide has been researched along with Necrosis in 11 studies
Diazoxide: A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group.
diazoxide : A benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Preconditioning with 10 microM adenosine limited necrosis (10." | 3.72 | Adenosine-mediated early preconditioning in mouse: protective signaling and concentration dependent effects. ( Headrick, JP; Peart, J, 2003) |
| " The purpose of this study was to examine the effects of the mitochondrial potassium ATP-sensitive channel opener diazoxide on regional and global myocardial protection using a model of acute myocardial infarction." | 3.71 | Selective opening of mitochondrial ATP-sensitive potassium channels during surgically induced myocardial ischemia decreases necrosis and apoptosis. ( Cowan, DB; Federman, M; Levitsky, S; McCully, JD; Toyoda, Y; Wakiyama, H, 2002) |
| "Propofol treatments were initiated at various time intervals: 1 or 24 h before ischemia, only during ischemia, or only during reperfusion." | 1.35 | The role of KATP channels on propofol preconditioning in a cellular model of renal ischemia-reperfusion. ( Assad, AR; Capella, MA; Delou, JM; Fonseca, LM; Lopes, AG; Nascimento, JH; Verçosa, N; Villela, NR, 2009) |
| " Therefore, pharmacological preconditioning with diazoxide in combination with adenosine and a nitric oxide donor (triple-combination pharmacological preconditioning) may enhance cardioprotection." | 1.32 | Integrated pharmacological preconditioning in combination with adenosine, a mitochondrial KATP channel opener and a nitric oxide donor. ( Imamura, H; Kido, M; Nakao, S; Ninomiya, H; Okada, T; Otani, H; Shingu, K; Uchiyama, T; Uchiyama, Y, 2003) |
| "Diazoxide-treated animals were dosed (5 mg/kg) 15 minutes before cross-clamp." | 1.31 | Pharmacological preconditioning ameliorates neurological injury in a model of spinal cord ischemia. ( Baumgartner, WA; Bethea, BT; Blue, ME; Caparrelli, DJ; Cattaneo, SM; Eberhart, C; Gott, VL; Johnston, MV; Marbán, E; Shake, JG, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 9 (81.82) | 29.6817 |
| 2010's | 2 (18.18) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liang, W | 1 |
| Chen, M | 1 |
| Zheng, D | 1 |
| Li, J | 1 |
| Song, M | 1 |
| Zhang, W | 1 |
| Feng, J | 1 |
| Lan, J | 1 |
| Assad, AR | 1 |
| Delou, JM | 1 |
| Fonseca, LM | 1 |
| Villela, NR | 1 |
| Nascimento, JH | 1 |
| Verçosa, N | 1 |
| Lopes, AG | 1 |
| Capella, MA | 1 |
| Foster, DB | 1 |
| Ho, AS | 1 |
| Rucker, J | 1 |
| Garlid, AO | 1 |
| Chen, L | 1 |
| Sidor, A | 1 |
| Garlid, KD | 1 |
| O'Rourke, B | 1 |
| Caparrelli, DJ | 1 |
| Cattaneo, SM | 1 |
| Bethea, BT | 1 |
| Shake, JG | 1 |
| Eberhart, C | 1 |
| Blue, ME | 1 |
| Marbán, E | 1 |
| Johnston, MV | 1 |
| Baumgartner, WA | 1 |
| Gott, VL | 1 |
| Ichinose, M | 1 |
| Yonemochi, H | 1 |
| Sato, T | 1 |
| Saikawa, T | 1 |
| Peart, J | 1 |
| Headrick, JP | 1 |
| Uchiyama, Y | 1 |
| Otani, H | 1 |
| Okada, T | 1 |
| Uchiyama, T | 1 |
| Ninomiya, H | 1 |
| Kido, M | 1 |
| Imamura, H | 1 |
| Nakao, S | 1 |
| Shingu, K | 1 |
| Duncker, DJ | 1 |
| Verdouw, PD | 1 |
| Ishida, H | 1 |
| Hale, SL | 1 |
| Kloner, RA | 1 |
| Wakiyama, H | 1 |
| Cowan, DB | 1 |
| Toyoda, Y | 1 |
| Federman, M | 1 |
| Levitsky, S | 1 |
| McCully, JD | 1 |
1 review available for diazoxide and Necrosis
| Article | Year |
|---|---|
[The research method for investigating the role of the mitochondrial permeability transition pore in cell death].
Topics: Apoptosis; Arsenicals; Calcium; Cyclosporine; Cytochromes c; Diazoxide; Humans; Ion Channels; Mitoch | 2004 |
10 other studies available for diazoxide and Necrosis
| Article | Year |
|---|---|
The Opening of ATP-Sensitive K+ Channels Protects H9c2 Cardiac Cells Against the High Glucose-Induced Injury and Inflammation by Inhibiting the ROS-TLR4-Necroptosis Pathway.
Topics: Acetylcysteine; Animals; Apoptosis; Cell Line; Decanoic Acids; Diazoxide; Gene Expression Regulation | 2017 |
The role of KATP channels on propofol preconditioning in a cellular model of renal ischemia-reperfusion.
Topics: Adenosine Triphosphate; Animals; Antimycin A; Apoptosis; Cell Survival; Cytoprotection; Decanoic Aci | 2009 |
Mitochondrial ROMK channel is a molecular component of mitoK(ATP).
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Apoptosis; Bee Venoms; Cattle; CHO Cells; Criceti | 2012 |
Pharmacological preconditioning ameliorates neurological injury in a model of spinal cord ischemia.
Topics: Animals; Diazoxide; Ischemic Preconditioning; Male; Membrane Proteins; Necrosis; Neurologic Examinat | 2002 |
Diazoxide triggers cardioprotection against apoptosis induced by oxidative stress.
Topics: Animals; Animals, Newborn; Apoptosis; Cells, Cultured; Diazoxide; Diuretics; Flow Cytometry; Heart D | 2003 |
Adenosine-mediated early preconditioning in mouse: protective signaling and concentration dependent effects.
Topics: Adenosine; Adenosine Diphosphate; Alkaloids; Animals; Benzophenanthridines; Calcium Channel Blockers | 2003 |
Integrated pharmacological preconditioning in combination with adenosine, a mitochondrial KATP channel opener and a nitric oxide donor.
Topics: Adenosine; Animals; Combined Modality Therapy; Coronary Circulation; Creatine Kinase; Diazoxide; Dis | 2003 |
Cardioprotective effect of diazoxide is mediated by activation of sarcolemmal but not mitochondrial ATP-sensitive potassium channels in mice.
Topics: Adenosine Triphosphate; Animals; Cardiotonic Agents; Diazoxide; Disease Models, Animal; Dose-Respons | 2003 |
Effect of combined K(ATP) channel activation and Na(+)/H(+) exchange inhibition on infarct size in rabbits.
Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Decanoic Acids; Diazoxide; Guanidines; Heart Rate; | 2000 |
Selective opening of mitochondrial ATP-sensitive potassium channels during surgically induced myocardial ischemia decreases necrosis and apoptosis.
Topics: Animals; Apoptosis; Cardioplegic Solutions; Diazoxide; Female; Heart Arrest, Induced; Male; Membrane | 2002 |