Page last updated: 2024-08-07 15:21:10
Fatty-acid amide hydrolase 1
A fatty-acid amide hydrolase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O00519]
Synonyms
EC 3.5.1.99;
Anandamide amidohydrolase 1;
Fatty acid ester hydrolase;
3.1.1.-;
Oleamide hydrolase 1
Research
Bioassay Publications (58)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 23 (39.66) | 29.6817 |
| 2010's | 30 (51.72) | 24.3611 |
| 2020's | 5 (8.62) | 2.80 |
Compounds (58)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| disulfiram | Homo sapiens (human) | IC50 | 363.0780 | 1 | 1 |
| phenylmethylsulfonyl fluoride | Homo sapiens (human) | IC50 | 13.0000 | 1 | 1 |
| propofol | Homo sapiens (human) | IC50 | 52.0000 | 1 | 1 |
| 1,6-bis(cyclohexyloximinocarbonyl)hexane | Homo sapiens (human) | IC50 | 70.0000 | 1 | 1 |
| thiram | Homo sapiens (human) | IC50 | 44.6684 | 1 | 1 |
| carbaryl | Homo sapiens (human) | IC50 | 30.0000 | 2 | 2 |
| bis(1-piperidylthiocarbonyl)disulfide | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| tetramethylthiuram monosulfide | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| 4,4'-dithiodimorpholine | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| benzil | Homo sapiens (human) | IC50 | 40.0000 | 2 | 2 |
| phenyl trifluoromethyl ketone | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| hydratropic acid | Homo sapiens (human) | IC50 | 1,230.2700 | 1 | 1 |
| methyl diethyldithiocarbamate | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| n-phenylmaleimide | Homo sapiens (human) | IC50 | 229.0000 | 1 | 1 |
| dronabinol | Homo sapiens (human) | IC50 | 43.6000 | 1 | 1 |
| 1,6-bismaleimidohexane | Homo sapiens (human) | IC50 | 18.2000 | 1 | 1 |
| phenmedipham | Homo sapiens (human) | IC50 | 0.2645 | 2 | 2 |
| amperozide | Homo sapiens (human) | IC50 | 0.8975 | 2 | 2 |
| n-benzylmaleimide | Homo sapiens (human) | IC50 | 186.0000 | 1 | 1 |
| n,n'-4-phenylenedimaleimide | Homo sapiens (human) | IC50 | 13.4900 | 1 | 1 |
| n-(2-methoxyphenyl)maleimide | Homo sapiens (human) | IC50 | 500.0000 | 1 | 1 |
| n-(4-bromophenyl)maleimide | Homo sapiens (human) | IC50 | 51.0000 | 1 | 1 |
| 3-octylthio-1,1,1-trifluoro-2-propanone | Homo sapiens (human) | IC50 | 0.2650 | 2 | 2 |
| arachidonic acid | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| oleic acid | Homo sapiens (human) | Ki | 6.0000 | 1 | 1 |
| urb 597 | Homo sapiens (human) | IC50 | 0.2130 | 32 | 33 |
| jnj-1661010 | Homo sapiens (human) | IC50 | 0.0296 | 7 | 7 |
| orlistat | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| 2-octyl-gamma-bromoacetoacetate | Homo sapiens (human) | Ki | 0.8200 | 1 | 1 |
| arachidonyltrifluoromethane | Homo sapiens (human) | IC50 | 1.0082 | 3 | 3 |
| anandamide | Homo sapiens (human) | IC50 | 3.7500 | 2 | 2 |
| anandamide | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| glyceryl 2-arachidonate | Homo sapiens (human) | Ki | 5.0000 | 1 | 1 |
| oleylamide | Homo sapiens (human) | IC50 | 68.0000 | 1 | 1 |
| n-arachidonylglycine | Homo sapiens (human) | IC50 | 7.0000 | 1 | 1 |
| N-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoylethanolamine | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| arachidonyl-2-chloroethylamide | Homo sapiens (human) | IC50 | 0.9000 | 1 | 1 |
| 6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2h-pyran-2-one | Homo sapiens (human) | IC50 | 0.8000 | 1 | 1 |
| guineensine | Homo sapiens (human) | IC50 | 46.8000 | 1 | 1 |
| omdm-2 cpd | Homo sapiens (human) | IC50 | 23.2900 | 1 | 1 |
| cay 10499 | Homo sapiens (human) | IC50 | 0.0310 | 6 | 6 |
| CAY10435 | Homo sapiens (human) | IC50 | 0.0168 | 1 | 2 |
| CAY10435 | Homo sapiens (human) | Ki | 0.0006 | 1 | 1 |
| arachidonoylserotonin | Homo sapiens (human) | IC50 | 11.2000 | 3 | 3 |
| urb 524 | Homo sapiens (human) | IC50 | 0.0630 | 2 | 2 |
| ol-135 | Homo sapiens (human) | IC50 | 0.1648 | 16 | 16 |
| ol-135 | Homo sapiens (human) | Ki | 0.5278 | 9 | 9 |
| methyl arachidonylfluorophosphonate | Homo sapiens (human) | IC50 | 0.0012 | 4 | 4 |
| urb602 | Homo sapiens (human) | IC50 | 5.7022 | 2 | 2 |
| n-benzylhexadecanamide | Homo sapiens (human) | IC50 | 500.0000 | 1 | 1 |
| ly2183240 | Homo sapiens (human) | IC50 | 0.0248 | 4 | 4 |
| methylphenidate | Homo sapiens (human) | IC50 | 0.4630 | 7 | 7 |
| 1-(4-chlorophenyl)-3-(3-(6-pyrrolidin-1-ylpyridin-2-yl)phenyl)urea | Homo sapiens (human) | IC50 | 2.1000 | 1 | 1 |
| 4-(4-(3-adamantan-1-ylureido)cyclohexyloxy)benzoic acid | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| t-tucb | Homo sapiens (human) | IC50 | 1.0667 | 2 | 3 |
| pf 04457845 | Homo sapiens (human) | IC50 | 0.0167 | 7 | 2 |
| jzl 184 | Homo sapiens (human) | IC50 | 10.0003 | 6 | 6 |
| pf 3845 | Homo sapiens (human) | IC50 | 0.0023 | 2 | 2 |
| pf 750 | Homo sapiens (human) | IC50 | 0.2678 | 10 | 10 |
| azd7687 | Homo sapiens (human) | IC50 | 3.7000 | 1 | 1 |
| jzl195 | Homo sapiens (human) | IC50 | 0.0077 | 3 | 3 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| oleylamide | Homo sapiens (human) | Km | 5.0000 | 1 | 1 |
The discovery and development of inhibitors of fatty acid amide hydrolase (FAAH).Bioorganic & medicinal chemistry letters, , Aug-15, Volume: 21, Issue:16, 2011
Discovery and development of fatty acid amide hydrolase (FAAH) inhibitors.Journal of medicinal chemistry, , Dec-11, Volume: 51, Issue:23, 2008
Further exploration of the structure-activity relationship of dual soluble epoxide hydrolase/fatty acid amide hydrolase inhibitors.Bioorganic & medicinal chemistry, , 12-01, Volume: 51, 2021
Identification and optimization of soluble epoxide hydrolase inhibitors with dual potency towards fatty acid amide hydrolase.Bioorganic & medicinal chemistry letters, , 02-15, Volume: 28, Issue:4, 2018
Therapeutic Potential of Fatty Acid Amide Hydrolase, Monoacylglycerol Lipase, and N-Acylethanolamine Acid Amidase Inhibitors.Journal of medicinal chemistry, , 01-12, Volume: 60, Issue:1, 2017
Design, synthesis and biological evaluation of potent FAAH inhibitors.Bioorganic & medicinal chemistry letters, , 06-01, Volume: 26, Issue:11, 2016
Piperidinyl thiazole isoxazolines: A new series of highly potent, slowly reversible FAAH inhibitors with analgesic properties.Bioorganic & medicinal chemistry letters, , 06-15, Volume: 26, Issue:12, 2016
Pyrazole phenylcyclohexylcarbamates as inhibitors of human fatty acid amide hydrolases (FAAH).European journal of medicinal chemistry, , Jun-05, Volume: 97, 2015
Functionalization of β-caryophyllene generates novel polypharmacology in the endocannabinoid system.ACS chemical biology, , Jul-18, Volume: 9, Issue:7, 2014
Switching cannabinoid response from CB(2) agonists to FAAH inhibitors.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 24, Issue:5, 2014
Chiral 1,3,4-oxadiazol-2-ones as highly selective FAAH inhibitors.Journal of medicinal chemistry, , Nov-14, Volume: 56, Issue:21, 2013
(4-Phenoxyphenyl)tetrazolecarboxamides and related compounds as dual inhibitors of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL).European journal of medicinal chemistry, , Volume: 63, 2013
Synthesis, SAR study, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase (FAAH) inhibitors.Bioorganic & medicinal chemistry, , Jan-01, Volume: 21, Issue:1, 2013
Discovery of potent inhibitors of human and mouse fatty acid amide hydrolases.Journal of medicinal chemistry, , Aug-09, Volume: 55, Issue:15, 2012
The First Dual ChE/FAAH Inhibitors: New Perspectives for Alzheimer's Disease?ACS medicinal chemistry letters, , Mar-08, Volume: 3, Issue:3, 2012
The discovery and development of inhibitors of fatty acid amide hydrolase (FAAH).Bioorganic & medicinal chemistry letters, , Aug-15, Volume: 21, Issue:16, 2011
New FAAH inhibitors based on 3-carboxamido-5-aryl-isoxazole scaffold that protect against experimental colitis.Bioorganic & medicinal chemistry, , Jun-15, Volume: 19, Issue:12, 2011
Identification of potent, noncovalent fatty acid amide hydrolase (FAAH) inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 21, Issue:8, 2011
SAR and LC/MS studies of β-lactamic inhibitors of human fatty acid amide hydrolase (hFAAH): evidence of a nonhydrolytic process.Journal of medicinal chemistry, , Oct-13, Volume: 54, Issue:19, 2011
Fatty acid amide hydrolase inhibitors. Surprising selectivity of chiral azetidine ureas.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 19, Issue:15, 2009
Synthesis and evaluation of benzothiazole-based analogues as novel, potent, and selective fatty acid amide hydrolase inhibitors.Journal of medicinal chemistry, , Jan-08, Volume: 52, Issue:1, 2009
Discovery and development of fatty acid amide hydrolase (FAAH) inhibitors.Journal of medicinal chemistry, , Dec-11, Volume: 51, Issue:23, 2008
Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity.Biochemistry, , Nov-13, Volume: 46, Issue:45, 2007
Synthesis, SAR study, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase (FAAH) inhibitors.Bioorganic & medicinal chemistry, , Jan-01, Volume: 21, Issue:1, 2013
The discovery and development of inhibitors of fatty acid amide hydrolase (FAAH).Bioorganic & medicinal chemistry letters, , Aug-15, Volume: 21, Issue:16, 2011
Fatty acid amide hydrolase inhibitors. Surprising selectivity of chiral azetidine ureas.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 19, Issue:15, 2009
Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 18, Issue:17, 2008
Bis(dialkylaminethiocarbonyl)disulfides as potent and selective monoglyceride lipase inhibitors.Journal of medicinal chemistry, , Nov-26, Volume: 52, Issue:22, 2009
Synthesis and in vitro evaluation of N-substituted maleimide derivatives as selective monoglyceride lipase inhibitors.Journal of medicinal chemistry, , Dec-10, Volume: 52, Issue:23, 2009
The endocannabinoid system: drug targets, lead compounds, and potential therapeutic applications.Journal of medicinal chemistry, , Aug-11, Volume: 48, Issue:16, 2005
Antitumorigenic Properties of Omega-3 Endocannabinoid Epoxides.Journal of medicinal chemistry, , 07-12, Volume: 61, Issue:13, 2018
Discovery and development of fatty acid amide hydrolase (FAAH) inhibitors.Journal of medicinal chemistry, , Dec-11, Volume: 51, Issue:23, 2008
Oxygenated metabolites of anandamide and 2-arachidonoylglycerol: conformational analysis and interaction with cannabinoid receptors, membrane transporter, and fatty acid amide hydrolase.Journal of medicinal chemistry, , Aug-15, Volume: 45, Issue:17, 2002
Discovery and development of fatty acid amide hydrolase (FAAH) inhibitors.Journal of medicinal chemistry, , Dec-11, Volume: 51, Issue:23, 2008
The endocannabinoid system: drug targets, lead compounds, and potential therapeutic applications.Journal of medicinal chemistry, , Aug-11, Volume: 48, Issue:16, 2005
Pyrazole phenylcyclohexylcarbamates as inhibitors of human fatty acid amide hydrolases (FAAH).European journal of medicinal chemistry, , Jun-05, Volume: 97, 2015
(4-Phenoxyphenyl)tetrazolecarboxamides and related compounds as dual inhibitors of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL).European journal of medicinal chemistry, , Volume: 63, 2013
Bis(dialkylaminethiocarbonyl)disulfides as potent and selective monoglyceride lipase inhibitors.Journal of medicinal chemistry, , Nov-26, Volume: 52, Issue:22, 2009
Chiral 1,3,4-oxadiazol-2-ones as highly selective FAAH inhibitors.Journal of medicinal chemistry, , Nov-14, Volume: 56, Issue:21, 2013
The discovery and development of inhibitors of fatty acid amide hydrolase (FAAH).Bioorganic & medicinal chemistry letters, , Aug-15, Volume: 21, Issue:16, 2011
New Approaches to Cancer Therapy: Combining Fatty Acid Amide Hydrolase (FAAH) Inhibition with Peroxisome Proliferator-Activated Receptors (PPARs) Activation.Journal of medicinal chemistry, , 12-26, Volume: 62, Issue:24, 2019
Inhibition of FAAH, TRPV1, and COX2 by NSAID-serotonin conjugates.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 24, Issue:24, 2014
The endocannabinoid system: drug targets, lead compounds, and potential therapeutic applications.Journal of medicinal chemistry, , Aug-11, Volume: 48, Issue:16, 2005
The discovery and development of inhibitors of fatty acid amide hydrolase (FAAH).Bioorganic & medicinal chemistry letters, , Aug-15, Volume: 21, Issue:16, 2011
Discovery and development of fatty acid amide hydrolase (FAAH) inhibitors.Journal of medicinal chemistry, , Dec-11, Volume: 51, Issue:23, 2008
Discovery and evaluation of novel FAAH inhibitors in neuropathic pain model.Bioorganic & medicinal chemistry letters, , 01-15, Volume: 29, Issue:2, 2019
Piperidinyl thiazole isoxazolines: A new series of highly potent, slowly reversible FAAH inhibitors with analgesic properties.Bioorganic & medicinal chemistry letters, , 06-15, Volume: 26, Issue:12, 2016
Macamides and their synthetic analogs: evaluation of in vitro FAAH inhibition.Bioorganic & medicinal chemistry, , Sep-01, Volume: 21, Issue:17, 2013
Discovery of potent inhibitors of human and mouse fatty acid amide hydrolases.Journal of medicinal chemistry, , Aug-09, Volume: 55, Issue:15, 2012
SAR and LC/MS studies of β-lactamic inhibitors of human fatty acid amide hydrolase (hFAAH): evidence of a nonhydrolytic process.Journal of medicinal chemistry, , Oct-13, Volume: 54, Issue:19, 2011
The discovery and development of inhibitors of fatty acid amide hydrolase (FAAH).Bioorganic & medicinal chemistry letters, , Aug-15, Volume: 21, Issue:16, 2011
Fatty acid amide hydrolase inhibitors. Surprising selectivity of chiral azetidine ureas.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 19, Issue:15, 2009
Novel ketooxazole based inhibitors of fatty acid amide hydrolase (FAAH).Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 18, Issue:6, 2008
Optimization of alpha-ketooxazole inhibitors of fatty acid amide hydrolase.Journal of medicinal chemistry, , Feb-28, Volume: 51, Issue:4, 2008
Discovery and development of fatty acid amide hydrolase (FAAH) inhibitors.Journal of medicinal chemistry, , Dec-11, Volume: 51, Issue:23, 2008
Correlation of inhibitor effects on enzyme activity and thermal stability for the integral membrane protein fatty acid amide hydrolase.Bioorganic & medicinal chemistry letters, , Nov-15, Volume: 18, Issue:22, 2008
Optimization of the central heterocycle of alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase.Journal of medicinal chemistry, , Aug-14, Volume: 51, Issue:15, 2008
Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality.Bioorganic & medicinal chemistry, , Feb-15, Volume: 16, Issue:4, 2008
Structure-activity relationships of alpha-ketooxazole inhibitors of fatty acid amide hydrolase.Journal of medicinal chemistry, , Jul-12, Volume: 50, Issue:14, 2007
Potent and selective alpha-ketoheterocycle-based inhibitors of the anandamide and oleamide catabolizing enzyme, fatty acid amide hydrolase.Journal of medicinal chemistry, , Mar-08, Volume: 50, Issue:5, 2007
Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity.Biochemistry, , Nov-13, Volume: 46, Issue:45, 2007
Discovery of a potent, selective, and efficacious class of reversible alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as analgesics.Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
Discovery of an exceptionally potent and selective class of fatty acid amide hydrolase inhibitors enlisting proteome-wide selectivity screening: concurrent optimization of enzyme inhibitor potency and selectivity.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 15, Issue:5, 2005
Discovery of potent inhibitors of human and mouse fatty acid amide hydrolases.Journal of medicinal chemistry, , Aug-09, Volume: 55, Issue:15, 2012
Bis(dialkylaminethiocarbonyl)disulfides as potent and selective monoglyceride lipase inhibitors.Journal of medicinal chemistry, , Nov-26, Volume: 52, Issue:22, 2009
Synthesis and in vitro evaluation of N-substituted maleimide derivatives as selective monoglyceride lipase inhibitors.Journal of medicinal chemistry, , Dec-10, Volume: 52, Issue:23, 2009
The endocannabinoid system: drug targets, lead compounds, and potential therapeutic applications.Journal of medicinal chemistry, , Aug-11, Volume: 48, Issue:16, 2005
Bis(dialkylaminethiocarbonyl)disulfides as potent and selective monoglyceride lipase inhibitors.Journal of medicinal chemistry, , Nov-26, Volume: 52, Issue:22, 2009
Synthesis and in vitro evaluation of N-substituted maleimide derivatives as selective monoglyceride lipase inhibitors.Journal of medicinal chemistry, , Dec-10, Volume: 52, Issue:23, 2009
Synthesis, SAR study, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase (FAAH) inhibitors.Bioorganic & medicinal chemistry, , Jan-01, Volume: 21, Issue:1, 2013
The discovery and development of inhibitors of fatty acid amide hydrolase (FAAH).Bioorganic & medicinal chemistry letters, , Aug-15, Volume: 21, Issue:16, 2011
Bis(dialkylaminethiocarbonyl)disulfides as potent and selective monoglyceride lipase inhibitors.Journal of medicinal chemistry, , Nov-26, Volume: 52, Issue:22, 2009
Synthesis and in vitro evaluation of N-substituted maleimide derivatives as selective monoglyceride lipase inhibitors.Journal of medicinal chemistry, , Dec-10, Volume: 52, Issue:23, 2009
Therapeutic Potential of Fatty Acid Amide Hydrolase, Monoacylglycerol Lipase, and N-Acylethanolamine Acid Amidase Inhibitors.Journal of medicinal chemistry, , 01-12, Volume: 60, Issue:1, 2017
Fatty acid amide hydrolase inhibitors. Surprising selectivity of chiral azetidine ureas.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 19, Issue:15, 2009
Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity.Biochemistry, , Nov-13, Volume: 46, Issue:45, 2007
Discovery and evaluation of novel FAAH inhibitors in neuropathic pain model.Bioorganic & medicinal chemistry letters, , 01-15, Volume: 29, Issue:2, 2019
Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and Selective Urea FAAH Inhibitor.ACS medicinal chemistry letters, , Feb-10, Volume: 2, Issue:2, 2011
[no title available],
Discovery of Trifluoromethyl Glycol Carbamates as Potent and Selective Covalent Monoacylglycerol Lipase (MAGL) Inhibitors for Treatment of Neuroinflammation.Journal of medicinal chemistry, , 04-12, Volume: 61, Issue:7, 2018
Development and characterization of endocannabinoid hydrolases FAAH and MAGL inhibitors bearing a benzotriazol-1-yl carboxamide scaffold.Bioorganic & medicinal chemistry, , Nov-01, Volume: 20, Issue:21, 2012
Synthesis and in vitro evaluation of N-substituted maleimide derivatives as selective monoglyceride lipase inhibitors.Journal of medicinal chemistry, , Dec-10, Volume: 52, Issue:23, 2009
Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects.Nature chemical biology, , Volume: 5, Issue:1, 2009
Decoding endocannabinoid signaling.Nature chemical biology, , Volume: 5, Issue:1, 2009
Therapeutic Potential of Fatty Acid Amide Hydrolase, Monoacylglycerol Lipase, and N-Acylethanolamine Acid Amidase Inhibitors.Journal of medicinal chemistry, , 01-12, Volume: 60, Issue:1, 2017
Macamides and their synthetic analogs: evaluation of in vitro FAAH inhibition.Bioorganic & medicinal chemistry, , Sep-01, Volume: 21, Issue:17, 2013
Synthesis, SAR study, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase (FAAH) inhibitors.Bioorganic & medicinal chemistry, , Jan-01, Volume: 21, Issue:1, 2013
SAR and LC/MS studies of β-lactamic inhibitors of human fatty acid amide hydrolase (hFAAH): evidence of a nonhydrolytic process.Journal of medicinal chemistry, , Oct-13, Volume: 54, Issue:19, 2011
Fatty acid amide hydrolase inhibitors. Surprising selectivity of chiral azetidine ureas.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 19, Issue:15, 2009
Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity.Biochemistry, , Nov-13, Volume: 46, Issue:45, 2007
Design and synthesis of endocannabinoid enzyme inhibitors for ocular indications.Bioorganic & medicinal chemistry letters, , 07-15, Volume: 68, 2022
Synthesis and evaluation of dual fatty acid amide hydrolase-monoacylglycerol lipase inhibition and antinociceptive activities of 4-methylsulfonylaniline-derived semicarbazones.Bioorganic & medicinal chemistry, , 04-15, Volume: 60, 2022
Structure-based design of novel donepezil-like hybrids for a multi-target approach to the therapy of Alzheimer's disease.European journal of medicinal chemistry, , Jul-05, Volume: 237, 2022
Enables
This protein enables 6 target(s):
| Target | Category | Definition |
|---|
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| phospholipid binding | molecular function | Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester. [ISBN:0198506732] |
| fatty acid amide hydrolase activity | molecular function | Catalysis of the hydrolysis of a fatty acid amide to yield a fatty acid. [PMID:15952893] |
| identical protein binding | molecular function | Binding to an identical protein or proteins. [GOC:jl] |
| acylglycerol lipase activity | molecular function | Catalysis of the reaction: H2O + acylglycerol = a fatty acid + glycerol. [EC:3.1.1.23, MetaCyc:3.1.1.23-RXN] |
| amidase activity | molecular function | Catalysis of the reaction: a monocarboxylic acid amide + H2O = a monocarboxylate + NH3. [EC:3.5.1.4] |
Located In
This protein is located in 3 target(s):
| Target | Category | Definition |
|---|
| endoplasmic reticulum membrane | cellular component | The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah] |
| cytoskeleton | cellular component | A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. [GOC:mah, PMID:16959967, PMID:27419875] |
| organelle membrane | cellular component | A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle. [GOC:dos, GOC:mah] |
Involved In
This protein is involved in 4 target(s):
| Target | Category | Definition |
|---|
| fatty acid catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. [GOC:go_curators] |
| arachidonic acid metabolic process | biological process | The chemical reactions and pathways involving arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer. [ISBN:0198506732] |
| positive regulation of vasoconstriction | biological process | Any process that activates or increases the frequency, rate or extent of vasoconstriction. [GOC:go_curators] |
| monoacylglycerol catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of monoacylglycerol, any ester of glycerol in which any one of its hydroxyl groups has been acylated with a fatty acid, the other being non-esterified. [PMID:25290914] |