Voltage-dependent calcium channel gamma-1 subunit

A voltage-dependent calcium channel gamma-1 subunit that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q06432]

Dihydropyridine-sensitive L-type, skeletal muscle calcium channel subunit gamma

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
tacrine	Homo sapiens (human)	IC50	17.0000	1	1
nimodipine	Homo sapiens (human)	IC50	14.0000	1	1
ith 4012	Homo sapiens (human)	IC50	20.0000	1	1

This protein enables 3 target(s):

Target	Category	Definition
voltage-gated calcium channel activity	molecular function	Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:mtg_transport, GOC:tb, ISBN:0815340729]
calcium channel regulator activity	molecular function	Modulates the activity of a calcium channel. [GOC:mah]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]

This protein is located in 3 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
T-tubule	cellular component	Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane. [GOC:mtg_muscle, ISBN:0815316194]
sarcolemma	cellular component	The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers. [ISBN:0198506732]

This protein is part of 1 target(s):

Target	Category	Definition
L-type voltage-gated calcium channel complex	cellular component	A type of voltage-dependent calcium channel responsible for excitation-contraction coupling of skeletal, smooth, and cardiac muscle. 'L' stands for 'long-lasting' referring to the length of activation. [GOC:ame, PMID:12946355]

This protein is involved in 5 target(s):

Target	Category	Definition
positive regulation of muscle contraction	biological process	Any process that activates or increases the frequency, rate or extent of muscle contraction. [GOC:go_curators]
establishment of localization in cell	biological process	Any process, occuring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation. [GOC:ai, GOC:dos, GOC:dph, GOC:tb]
sarcoplasmic reticulum calcium ion transport	biological process	The directed movement of calcium ions (Ca2+) into, out of or within the sarcoplasmic reticulum. [GOC:BHF, GOC:vk]
calcium ion transmembrane transport	biological process	A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. [GOC:mah]
regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	biological process	Any process that modulates the frequency, rate or extent of generation of calcium ion transmembrane transport via high voltage-gated calcium channel. [GOC:dph, GOC:pg, GOC:TermGenie, PMID:1611048]