alloxan has been researched along with Necrosis in 15 studies
Alloxan: Acidic compound formed by oxidation of URIC ACID. It is isolated as an efflorescent crystalline hydrate.
alloxan : A member of the class of pyrimidones, the structure of which is that of perhydropyrimidine substituted at C-2, -4, -5 and -6 by oxo groups.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A new hypothesis ("Pi-pH hypothesis") for alloxan diabetes is presented." | 7.66 | A new hypothesis for alloxan diabetes. ( Boquist, L, 1980) |
| " On application of alloxan, this effect is caused by beta-cell necrosis and can be prevented by administration of melatonin, while in contrast, XO/HX did not lead to long-term morphological changes in the majority of the cells." | 3.70 | Influence of melatonin on free radical-induced changes in rat pancreatic beta-cells in vitro. ( Blume, R; Brömme, HJ; Ebelt, H; Mörke, W; Peschke, D; Peschke, E, 2000) |
| "The in vitro toxicity of the diabetogenic agent alloxan as documented by the induction of beta cell necrosis was studied in isolated ob/ob mouse pancreatic islets." | 3.69 | Comparative toxicity of alloxan, N-alkylalloxans and ninhydrin to isolated pancreatic islets in vitro. ( Jörns, A; Lenzen, S; Munday, R; Tiedge, M, 1997) |
| "A new hypothesis ("Pi-pH hypothesis") for alloxan diabetes is presented." | 3.66 | A new hypothesis for alloxan diabetes. ( Boquist, L, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (60.00) | 18.7374 |
| 1990's | 1 (6.67) | 18.2507 |
| 2000's | 4 (26.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Oršolić, N | 1 |
| Sirovina, D | 1 |
| Odeh, D | 1 |
| Gajski, G | 1 |
| Balta, V | 1 |
| Šver, L | 1 |
| Jazvinšćak Jembrek, M | 1 |
| PAPAY, SL | 1 |
| LAZAROW, A | 2 |
| PALAY, SL | 1 |
| Martin, JM | 1 |
| MERLINI, D | 1 |
| Kar, DM | 1 |
| Maharana, L | 1 |
| Pattnaik, S | 1 |
| Dash, GK | 1 |
| Boquist, L | 1 |
| Jörns, A | 1 |
| Munday, R | 1 |
| Tiedge, M | 1 |
| Lenzen, S | 1 |
| Ebelt, H | 1 |
| Peschke, D | 1 |
| Brömme, HJ | 1 |
| Mörke, W | 1 |
| Blume, R | 1 |
| Peschke, E | 1 |
| Ling, Z | 1 |
| Van de Casteele, M | 1 |
| Eizirik, DL | 1 |
| Pipeleers, DG | 1 |
| Harel, A | 1 |
| Bloch, O | 1 |
| Vardi, P | 1 |
| Bloch, K | 1 |
| Lazarus, SS | 1 |
| Shapiro, SH | 1 |
| Rohan, P | 1 |
| Scholz, WH | 1 |
| Solymoss, B | 1 |
| Varga, S | 1 |
| Rossini, AA | 1 |
| Berger, M | 1 |
| Shadden, J | 1 |
| Cahill, GF | 1 |
| Witzleben, CL | 1 |
15 other studies available for alloxan and Necrosis
| Article | Year |
|---|---|
Efficacy of Caffeic Acid on Diabetes and Its Complications in the Mouse.
Topics: Alloxan; Animals; Antioxidants; Apoptosis; Atherosclerosis; Blood Glucose; Caffeic Acids; Diabetes C | 2021 |
Protection against diabetes and production of hepatic necrosis by use of cysteine and alloxan in the rat.
Topics: Alloxan; Animals; Cysteine; Diabetes Mellitus; Liver; Liver Diseases; Necrosis; Rats | 1946 |
The production of ascites and liver necrosis following the injection of alloxan plus cysteine.
Topics: Alloxan; Animals; Ascites; Cysteine; Injections; Liver; Liver Diseases; Necrosis | 1946 |
[Hepatic necrosis with alloxan and chloroform].
Topics: Alloxan; Chloroform; Humans; Liver Diseases; Necrosis | 1954 |
[Pathogenesis of islet necrosis induced by alloxan].
Topics: Alloxan; Animals; Diabetes Mellitus, Experimental; Necrosis | 1952 |
Studies on hypoglycaemic activity of Solanum xanthocarpum Schrad. & Wendl. fruit extract in rats.
Topics: Alloxan; Animals; Blood Glucose; Cholesterol, VLDL; Diabetes Mellitus, Experimental; Diaphragm; Fatt | 2006 |
A new hypothesis for alloxan diabetes.
Topics: Alloxan; Animals; B-Lymphocytes; Cell Membrane Permeability; Cytoplasmic Granules; Cytosol; Diabetes | 1980 |
Comparative toxicity of alloxan, N-alkylalloxans and ninhydrin to isolated pancreatic islets in vitro.
Topics: Alloxan; Animals; Cell Death; Indicators and Reagents; Islets of Langerhans; Mice; Microscopy, Elect | 1997 |
Influence of melatonin on free radical-induced changes in rat pancreatic beta-cells in vitro.
Topics: Alloxan; Animals; Electron Spin Resonance Spectroscopy; Female; Free Radical Scavengers; Free Radica | 2000 |
Interleukin-1beta-induced alteration in a beta-cell phenotype can reduce cellular sensitivity to conditions that cause necrosis but not to cytokine-induced apoptosis.
Topics: Alloxan; Animals; Apoptosis; Cytokines; Dose-Response Relationship, Drug; Interleukin-1; Islets of L | 2000 |
Sensitivity of HaCat keratinocytes to diabetogenic toxins.
Topics: Alloxan; Analysis of Variance; Apoptosis; Benzamides; Cell Line; Cell Survival; Enzyme Inhibitors; G | 2002 |
Comparison of morphologic changes in nuclei of rabbit pancreatic islet B-cells induced by streptozotocin, alloxan, and in vitro necrosis.
Topics: Alloxan; Animals; Autolysis; Cell Nucleolus; Cell Nucleus; Chromatin; Female; Male; Microscopy, Elec | 1973 |
Influence of some glycemia-affecting factors on acute (conditioned) cutaneous necrosis.
Topics: Acute Disease; Alloxan; Animals; Dextrans; Fasting; Female; Glucose; Injections, Intravenous; Inject | 1974 |
Beta cell protection to alloxan necrosis by anomers of D-glucose.
Topics: Alloxan; Animals; Diabetes Mellitus, Experimental; Glucose; Islets of Langerhans; Male; Necrosis; Ra | 1974 |
The pathogenesis of iron hepatotoxicity.
Topics: Alloxan; Animals; Autoradiography; Blood Glucose; Chemical and Drug Induced Liver Injury; Ethionine; | 1969 |