Page last updated: 2024-08-07 16:09:15
Integrin alpha-L
An integrin alpha-L that is encoded in the genome of human. [PRO:CNA, UniProtKB:P20701]
Synonyms
CD11 antigen-like family member A;
Leukocyte adhesion glycoprotein LFA-1 alpha chain;
LFA-1A;
Leukocyte function-associated molecule 1 alpha chain
Research
Bioassay Publications (17)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (11.76) | 18.2507 |
| 2000's | 10 (58.82) | 29.6817 |
| 2010's | 4 (23.53) | 24.3611 |
| 2020's | 1 (5.88) | 2.80 |
Compounds (15)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| indole | Homo sapiens (human) | Kd | 300.0000 | 2 | 2 |
| 1,4-benzodioxan | Homo sapiens (human) | Kd | 10,000.0000 | 2 | 2 |
| 1-methylindole | Homo sapiens (human) | Kd | 1,400.0000 | 1 | 1 |
| lovastatin | Homo sapiens (human) | Kd | 12.9000 | 1 | 1 |
| birt 377 | Homo sapiens (human) | Kd | 0.0200 | 1 | 1 |
Fragment-based drug discovery.Journal of medicinal chemistry, , Jul-01, Volume: 47, Issue:14, 2004
Novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 2. Mechanism of inhibition and structure-based improvement of pharmaceutical properties.Journal of medicinal chemistry, , Apr-12, Volume: 44, Issue:8, 2001
Fragment-based drug discovery.Journal of medicinal chemistry, , Jul-01, Volume: 47, Issue:14, 2004
Novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 2. Mechanism of inhibition and structure-based improvement of pharmaceutical properties.Journal of medicinal chemistry, , Apr-12, Volume: 44, Issue:8, 2001
Insights into Protein-Ligand Interactions in Integrin Complexes: Advances in Structure Determinations.Journal of medicinal chemistry, , 06-11, Volume: 63, Issue:11, 2020
Design, synthesis, and functional evaluation of leukocyte function associated antigen-1 antagonists in early and late stages of cancer development.Journal of medicinal chemistry, , Feb-14, Volume: 56, Issue:3, 2013
Statin-derived 1,3-oxazinan-2-ones as submicromolar inhibitors of LFA-1/ICAM-1 interaction: stabilization of the metabolically labile vanillyl side chain.Bioorganic & medicinal chemistry letters, , May-17, Volume: 14, Issue:10, 2004
De novo design, synthesis, and in vitro activity of LFA-1 antagonists based on a bicyclic[5.5]hydantoin scaffold.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Second-generation lymphocyte function-associated antigen-1 inhibitors: 1H-imidazo[1,2-alpha]imidazol-2-one derivatives.Journal of medicinal chemistry, , Oct-21, Volume: 47, Issue:22, 2004
Discovery of tetrahydroisoquinoline (THIQ) derivatives as potent and orally bioavailable LFA-1/ICAM-1 antagonists.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 20, Issue:17, 2010
Discovery of potent antagonists of leukocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction. 3. Amide (C-ring) structure-activity relationship and improvement of overall properties of arylthio cinnamides.Journal of medicinal chemistry, , Aug-30, Volume: 44, Issue:18, 2001
Novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 2. Mechanism of inhibition and structure-based improvement of pharmaceutical properties.Journal of medicinal chemistry, , Apr-12, Volume: 44, Issue:8, 2001
Discovery of novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction. 4. Structure-activity relationship of substituents on the benzene ring of the cinnamide.Journal of medicinal chemistry, , Dec-06, Volume: 44, Issue:25, 2001
Discovery of novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 1. Identification of an additional binding pocket based on an anilino diaryl sulfide lead.Journal of medicinal chemistry, , Oct-19, Volume: 43, Issue:21, 2000
New β-Lactam Derivatives Modulate Cell Adhesion and Signaling Mediated by RGD-Binding and Leukocyte Integrins.Journal of medicinal chemistry, , 11-10, Volume: 59, Issue:21, 2016
Selective, tight-binding inhibitors of integrin alpha4beta1 that inhibit allergic airway responses.Journal of medicinal chemistry, , Mar-11, Volume: 42, Issue:5, 1999
Enables
This protein enables 5 target(s):
| Target | Category | Definition |
|---|
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| ICAM-3 receptor activity | molecular function | Combining with ICAM-3, intercellular adhesion molecule 3, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. ICAM-3, or CD50, are constitutively expressed on monocytes, granulocytes and lymphocytes; on physiological stimulation, they become transiently phosphorylated on serine residues. [GOC:ai, GOC:signaling, ISBN:0198506732, PMID:7515813] |
| metal ion binding | molecular function | Binding to a metal ion. [GOC:ai] |
| cell adhesion molecule binding | molecular function | Binding to a cell adhesion molecule. [GOC:ai] |
| integrin binding | molecular function | Binding to an integrin. [GOC:ceb] |
Located In
This protein is located in 5 target(s):
| Target | Category | Definition |
|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| cell surface | cellular component | The external part of the cell wall and/or plasma membrane. [GOC:jl, GOC:mtg_sensu, GOC:sm] |
| membrane | cellular component | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
| specific granule membrane | cellular component | The lipid bilayer surrounding a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase. [GOC:bf, PMID:7334549] |
| extracellular exosome | cellular component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
Active In
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|
| external side of plasma membrane | cellular component | The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface. [GOC:dos, GOC:tb] |
Part Of
This protein is part of 2 target(s):
| Target | Category | Definition |
|---|
| integrin alphaL-beta2 complex | cellular component | An integrin complex that comprises one alphaL subunit and one beta2 subunit. [PMID:12297042] |
| integrin complex | cellular component | A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. [PMID:17543136] |
Involved In
This protein is involved in 13 target(s):
| Target | Category | Definition |
|---|
| T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell | biological process | The change in morphology and behavior of a mature or immature T cell resulting from exposure to an antigen for which its T cell receptor is specific bound to an MHC molecule on an antigen presenting cell, leading to the initiation or perpetuation of an immune response. [GOC:add, ISBN:0781735149] |
| phagocytosis | biological process | A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles. [ISBN:0198506732] |
| inflammatory response | biological process | The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. [GO_REF:0000022, ISBN:0198506732] |
| cell adhesion | biological process | The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. [GOC:hb, GOC:pf] |
| heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules | biological process | The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell. [ISBN:0198506732] |
| leukocyte cell-cell adhesion | biological process | The attachment of a leukocyte to another cell via adhesion molecules. [GOC:go_curators] |
| cell-matrix adhesion | biological process | The binding of a cell to the extracellular matrix via adhesion molecules. [GOC:hb] |
| signal transduction | biological process | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. [GOC:go_curators, GOC:mtg_signaling_feb11] |
| integrin-mediated signaling pathway | biological process | The series of molecular signals initiated by an extracellular ligand binding to an integrin on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:mah, GOC:signaling] |
| memory T cell extravasation | biological process | The migration of a memory T cell from the blood vessels into the surrounding tissue. A memory T cell is a distinctly differentiated long-lived T cell that has the phenotype CD45RO-positive and CD127-positive. [CL:0000813, GOC:BHF] |
| receptor clustering | biological process | The receptor metabolic process that results in grouping of a set of receptors at a cellular location, often to amplify the sensitivity of a signaling response. [GOC:bf, GOC:jl, GOC:pr, PMID:19747931, PMID:21453460] |
| cell-cell adhesion | biological process | The attachment of one cell to another cell via adhesion molecules. [GOC:dos] |
| cell adhesion mediated by integrin | biological process | The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits. [GOC:add, PMID:12213832, PMID:14754902] |