Integrin alpha-L

An integrin alpha-L that is encoded in the genome of human. [PRO:CNA, UniProtKB:P20701]

Synonyms

CD11 antigen-like family member A;
Leukocyte adhesion glycoprotein LFA-1 alpha chain;
LFA-1A;
Leukocyte function-associated molecule 1 alpha chain

Research

Bioassay Publications (17)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	2 (11.76)	18.2507
2000's	10 (58.82)	29.6817
2010's	4 (23.53)	24.3611
2020's	1 (5.88)	2.80

Compounds (15)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
lovastatin	Homo sapiens (human)	IC50	3.0900	2	2
chlorfenethazine	Homo sapiens (human)	IC50	28.0000	1	1
2-bromohippuric acid	Homo sapiens (human)	IC50	313.5000	1	1
cucurbitacin r	Homo sapiens (human)	IC50	50.0000	1	1
benzotript	Homo sapiens (human)	IC50	169.0000	1	1
cucurbitacin d	Homo sapiens (human)	IC50	1.3600	1	1
nsc 106399	Homo sapiens (human)	IC50	0.1800	1	1
cucurbitacin i	Homo sapiens (human)	IC50	0.9500	1	1
birt 377	Homo sapiens (human)	IC50	0.0260	1	1
a 286982	Homo sapiens (human)	IC50	0.0417	6	6
bio 1211	Homo sapiens (human)	IC50	50.0004	2	2
sar 1118	Homo sapiens (human)	IC50	0.0415	2	2

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
indole	Homo sapiens (human)	Kd	300.0000	2	2
1,4-benzodioxan	Homo sapiens (human)	Kd	10,000.0000	2	2
1-methylindole	Homo sapiens (human)	Kd	1,400.0000	1	1
lovastatin	Homo sapiens (human)	Kd	12.9000	1	1
birt 377	Homo sapiens (human)	Kd	0.0200	1	1

Enables

This protein enables 5 target(s):

Target	Category	Definition
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
ICAM-3 receptor activity	molecular function	Combining with ICAM-3, intercellular adhesion molecule 3, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. ICAM-3, or CD50, are constitutively expressed on monocytes, granulocytes and lymphocytes; on physiological stimulation, they become transiently phosphorylated on serine residues. [GOC:ai, GOC:signaling, ISBN:0198506732, PMID:7515813]
metal ion binding	molecular function	Binding to a metal ion. [GOC:ai]
cell adhesion molecule binding	molecular function	Binding to a cell adhesion molecule. [GOC:ai]
integrin binding	molecular function	Binding to an integrin. [GOC:ceb]

Located In

This protein is located in 5 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
cell surface	cellular component	The external part of the cell wall and/or plasma membrane. [GOC:jl, GOC:mtg_sensu, GOC:sm]
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
specific granule membrane	cellular component	The lipid bilayer surrounding a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase. [GOC:bf, PMID:7334549]
extracellular exosome	cellular component	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
external side of plasma membrane	cellular component	The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface. [GOC:dos, GOC:tb]

Part Of

This protein is part of 2 target(s):

Target	Category	Definition
integrin alphaL-beta2 complex	cellular component	An integrin complex that comprises one alphaL subunit and one beta2 subunit. [PMID:12297042]
integrin complex	cellular component	A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. [PMID:17543136]

Involved In

This protein is involved in 13 target(s):

Target	Category	Definition
T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	biological process	The change in morphology and behavior of a mature or immature T cell resulting from exposure to an antigen for which its T cell receptor is specific bound to an MHC molecule on an antigen presenting cell, leading to the initiation or perpetuation of an immune response. [GOC:add, ISBN:0781735149]
phagocytosis	biological process	A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles. [ISBN:0198506732]
inflammatory response	biological process	The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. [GO_REF:0000022, ISBN:0198506732]
cell adhesion	biological process	The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. [GOC:hb, GOC:pf]
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	biological process	The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell. [ISBN:0198506732]
leukocyte cell-cell adhesion	biological process	The attachment of a leukocyte to another cell via adhesion molecules. [GOC:go_curators]
cell-matrix adhesion	biological process	The binding of a cell to the extracellular matrix via adhesion molecules. [GOC:hb]
signal transduction	biological process	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. [GOC:go_curators, GOC:mtg_signaling_feb11]
integrin-mediated signaling pathway	biological process	The series of molecular signals initiated by an extracellular ligand binding to an integrin on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:mah, GOC:signaling]
memory T cell extravasation	biological process	The migration of a memory T cell from the blood vessels into the surrounding tissue. A memory T cell is a distinctly differentiated long-lived T cell that has the phenotype CD45RO-positive and CD127-positive. [CL:0000813, GOC:BHF]
receptor clustering	biological process	The receptor metabolic process that results in grouping of a set of receptors at a cellular location, often to amplify the sensitivity of a signaling response. [GOC:bf, GOC:jl, GOC:pr, PMID:19747931, PMID:21453460]
cell-cell adhesion	biological process	The attachment of one cell to another cell via adhesion molecules. [GOC:dos]
cell adhesion mediated by integrin	biological process	The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits. [GOC:add, PMID:12213832, PMID:14754902]

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