Page last updated: 2024-08-04 07:52:59
phenanthrenes
Description
Phenanthrenes: POLYCYCLIC AROMATIC HYDROCARBONS composed of three fused BENZENE rings. [MeSH]
Cross-References
| ID Source | ID |
|---|
| PubMed CID | 168339423 |
| MeSH ID | M0016488 |
Synonyms (2)
| Synonym |
|---|
| phenanthrenes |
| methyl 4-phenylphenanthrene-2-carboxylate |
Research
Studies (7,378)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|
| pre-1990 | 1169 (15.84) | 18.7374 |
| 1990's | 726 (9.84) | 18.2507 |
| 2000's | 1999 (27.09) | 29.6817 |
| 2010's | 2678 (36.30) | 24.3611 |
| 2020's | 806 (10.92) | 2.80 |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|
| Trials | 110 (1.44%) | 5.53% |
| Reviews | 198 (2.60%) | 6.00% |
| Case Studies | 71 (0.93%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 7,239 (95.02%) | 84.16% |
| Substance | Studies | Classes | Roles | First Year | Last Year | Average Age | Relationship Strength | Trials | pre-1990 | 1990's | 2000's | 2010's | post-2020 |
|---|
| acetylcarnitine | | O-acylcarnitine | human metabolite | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| dinitrochlorobenzene | | C-nitro compound;
monochlorobenzenes | allergen;
epitope;
sensitiser | 1993 | 2004 | 25.5 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| 1,2,4-trichlorobenzene | | trichlorobenzene | | 2004 | 2010 | 16.8 | low | 0 | 0 | 0 | 4 | 0 | 0 |
| protocatechuic acid | | catechols;
dihydroxybenzoic acid | antineoplastic agent;
EC 1.1.1.25 (shikimate dehydrogenase) inhibitor;
EC 1.14.11.2 (procollagen-proline dioxygenase) inhibitor;
human xenobiotic metabolite;
plant metabolite | 1982 | 2018 | 18.9 | low | 0 | 2 | 0 | 2 | 4 | 0 |
| dihydro-3-coumaric acid | | monocarboxylic acid | Escherichia coli metabolite;
human xenobiotic metabolite | 1983 | 1983 | 41.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| gamma-aminobutyric acid | | amino acid zwitterion;
gamma-amino acid;
monocarboxylic acid | human metabolite;
neurotransmitter;
Saccharomyces cerevisiae metabolite;
signalling molecule | 1991 | 2021 | 22.0 | low | 0 | 0 | 4 | 0 | 1 | 1 |
| 4-hydroxybenzaldehyde | | hydroxybenzaldehyde | EC 1.14.17.1 (dopamine beta-monooxygenase) inhibitor;
mouse metabolite;
plant metabolite | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 4-hydroxyphenylacetic acid | | monocarboxylic acid;
phenols | fungal metabolite;
human metabolite;
mouse metabolite;
plant metabolite | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 4-hydroxybenzoic acid | | monohydroxybenzoic acid | algal metabolite;
plant metabolite | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 5-hydroxytryptophan | | hydroxytryptophan | human metabolite;
neurotransmitter | 1969 | 1969 | 55.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| acetic acid | | monocarboxylic acid | antimicrobial food preservative;
Daphnia magna metabolite;
food acidity regulator;
protic solvent | 1948 | 2022 | 20.6 | low | 0 | 1 | 0 | 0 | 3 | 1 |
| acetaldehyde | | aldehyde | carcinogenic agent;
EC 3.5.1.4 (amidase) inhibitor;
electron acceptor;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
mutagen;
oxidising agent;
Saccharomyces cerevisiae metabolite;
teratogenic agent | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| acetone | | ketone body;
methyl ketone;
propanones;
volatile organic compound | EC 3.5.1.4 (amidase) inhibitor;
human metabolite;
polar aprotic solvent | 1970 | 2022 | 23.1 | low | 0 | 2 | 0 | 5 | 1 | 1 |
| adenine | | 6-aminopurines;
purine nucleobase | Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite | 1964 | 2018 | 25.5 | low | 0 | 4 | 2 | 1 | 5 | 0 |
| agmatine | | guanidines;
primary amino compound | Escherichia coli metabolite;
mouse metabolite | 1986 | 1986 | 38.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| ammonium hydroxide | | azane;
gas molecular entity;
mononuclear parent hydride | EC 3.5.1.4 (amidase) inhibitor;
metabolite;
mouse metabolite;
neurotoxin;
NMR chemical shift reference compound;
nucleophilic reagent;
refrigerant | 1974 | 2022 | 13.3 | low | 0 | 1 | 0 | 1 | 4 | 1 |
| anthranilic acid | | aminobenzoic acid | human metabolite;
mouse metabolite | 1964 | 1964 | 60.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| quinacrine | | acridines;
aromatic ether;
organochlorine compound;
tertiary amino compound | antimalarial;
EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor | 1991 | 2001 | 28.1 | low | 0 | 0 | 9 | 2 | 0 | 0 |
| benzaldehyde | | benzaldehydes | EC 3.1.1.3 (triacylglycerol lipase) inhibitor;
EC 3.5.5.1 (nitrilase) inhibitor;
flavouring agent;
fragrance;
odorant receptor agonist;
plant metabolite | 2009 | 2011 | 14.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| benzene | | aromatic annulene;
benzenes;
volatile organic compound | carcinogenic agent;
environmental contaminant;
non-polar solvent | 1953 | 2020 | 28.0 | low | 0 | 11 | 3 | 10 | 12 | 0 |
| benzoic acid | | benzoic acids | algal metabolite;
antimicrobial food preservative;
drug allergen;
EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor;
EC 3.1.1.3 (triacylglycerol lipase) inhibitor;
human xenobiotic metabolite;
plant metabolite | 1991 | 2023 | 14.0 | low | 0 | 0 | 1 | 1 | 1 | 2 |
| benzyl alcohol | | benzyl alcohols | antioxidant;
fragrance;
metabolite;
solvent | 1996 | 1996 | 28.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| bromide | | halide anion;
monoatomic bromine | | 2007 | 2014 | 13.8 | low | 0 | 0 | 0 | 2 | 2 | 0 |
| 1-butanol | | alkyl alcohol;
primary alcohol;
short-chain primary fatty alcohol | human metabolite;
mouse metabolite;
protic solvent | 2000 | 2016 | 16.2 | low | 0 | 0 | 1 | 2 | 2 | 0 |
| carbamates | | amino-acid anion | | 1974 | 2018 | 28.3 | low | 0 | 3 | 0 | 1 | 2 | 0 |
| carbon monoxide | | carbon oxide;
gas molecular entity;
one-carbon compound | biomarker;
EC 1.9.3.1 (cytochrome c oxidase) inhibitor;
human metabolite;
ligand;
metabolite;
mitochondrial respiratory-chain inhibitor;
mouse metabolite;
neurotoxin;
neurotransmitter;
P450 inhibitor;
probe;
signalling molecule;
vasodilator agent | 1973 | 2018 | 22.8 | low | 1 | 2 | 2 | 3 | 4 | 0 |
| formic acid | | monocarboxylic acid | antibacterial agent;
astringent;
metabolite;
protic solvent;
solvent | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| carnitine | | amino-acid betaine | human metabolite;
mouse metabolite | 1973 | 2015 | 30.5 | low | 0 | 2 | 0 | 0 | 2 | 0 |
| catechol | | catechols | allelochemical;
genotoxin;
plant metabolite | 1999 | 2020 | 14.9 | low | 0 | 0 | 1 | 4 | 4 | 0 |
| methane | | alkane;
gas molecular entity;
mononuclear parent hydride;
one-carbon compound | bacterial metabolite;
fossil fuel;
greenhouse gas | 1953 | 2023 | 13.6 | low | 0 | 2 | 1 | 13 | 32 | 4 |
| choline | | cholines | allergen;
Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
neurotransmitter;
nutrient;
plant metabolite;
Saccharomyces cerevisiae metabolite | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| citric acid, anhydrous | | tricarboxylic acid | antimicrobial agent;
chelator;
food acidity regulator;
fundamental metabolite | 2008 | 2016 | 11.0 | low | 0 | 0 | 0 | 1 | 4 | 0 |
| chlorine | | halide anion;
monoatomic chlorine | cofactor;
Escherichia coli metabolite;
human metabolite | 1963 | 2017 | 25.3 | low | 0 | 2 | 3 | 1 | 4 | 0 |
| hydrochloric acid | | chlorine molecular entity;
gas molecular entity;
hydrogen halide;
mononuclear parent hydride | mouse metabolite | 2005 | 2009 | 17.0 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| coumarin | | coumarins | fluorescent dye;
human metabolite;
plant metabolite | 2006 | 2020 | 11.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| salicylic acid | | monohydroxybenzoic acid | algal metabolite;
antifungal agent;
antiinfective agent;
EC 1.11.1.11 (L-ascorbate peroxidase) inhibitor;
keratolytic drug;
plant hormone;
plant metabolite | 2004 | 2020 | 12.1 | low | 0 | 0 | 0 | 8 | 6 | 0 |
| gallic acid | | trihydroxybenzoic acid | antineoplastic agent;
antioxidant;
apoptosis inducer;
astringent;
cyclooxygenase 2 inhibitor;
EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor;
geroprotector;
human xenobiotic metabolite;
plant metabolite | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| 4-nitrophenylphosphate | | aryl phosphate | mouse metabolite | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| hydrogen sulfide | | gas molecular entity;
hydracid;
mononuclear parent hydride;
sulfur hydride | Escherichia coli metabolite;
genotoxin;
metabolite;
signalling molecule;
toxin;
vasodilator agent | 2010 | 2019 | 10.3 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| dihydrolipoic acid | | thio-fatty acid | antioxidant;
human metabolite;
neuroprotective agent | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| guaiacol | | guaiacols | disinfectant;
EC 1.1.1.25 (shikimate dehydrogenase) inhibitor;
expectorant;
plant metabolite | 1981 | 2020 | 17.7 | low | 0 | 1 | 5 | 7 | 6 | 0 |
| n(g),n(g')-dimethyl-l-arginine | | alpha-amino acid | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| malic acid | | 2-hydroxydicarboxylic acid;
C4-dicarboxylic acid | food acidity regulator;
fundamental metabolite | 2013 | 2019 | 8.0 | low | 0 | 0 | 0 | 0 | 3 | 0 |
| propionaldehyde | | alpha-CH2-containing aldehyde;
propanals | Escherichia coli metabolite | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| 1-aminocyclopropane-1-carboxylic acid | | amino acid zwitterion;
monocarboxylic acid;
non-proteinogenic alpha-amino acid | ethylene releasers;
plant metabolite | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 4-nitrobenzaldehyde | | benzaldehydes;
C-nitro compound | | 1985 | 1999 | 32.0 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| 3,4-dihydroxyphenylacetic acid | | catechols;
dihydroxyphenylacetic acid | human metabolite | 1991 | 2019 | 20.5 | low | 0 | 0 | 1 | 2 | 1 | 0 |
| dibenzofuran | | dibenzofurans;
mancude organic heterotricyclic parent;
polycyclic heteroarene | xenobiotic | 1999 | 2015 | 16.7 | low | 0 | 0 | 1 | 1 | 1 | 0 |
| creatine | | glycine derivative;
guanidines;
zwitterion | geroprotector;
human metabolite;
mouse metabolite;
neuroprotective agent;
nutraceutical | 1963 | 2001 | 42.0 | low | 0 | 1 | 0 | 1 | 0 | 0 |
| cytosine | | aminopyrimidine;
pyrimidine nucleobase;
pyrimidone | Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite | 1971 | 2013 | 35.5 | low | 0 | 3 | 0 | 0 | 1 | 0 |
| lactic acid | | 2-hydroxy monocarboxylic acid | algal metabolite;
Daphnia magna metabolite | 1952 | 2022 | 18.8 | low | 0 | 1 | 0 | 7 | 3 | 1 |
| dihydrolipoamide | | dithiol;
monocarboxylic acid amide | cofactor;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite | 1993 | 1993 | 31.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| dimethylglycine | | amino acid zwitterion;
N-methyl-amino acid;
N-methylglycines | Daphnia magna metabolite;
human metabolite;
mouse metabolite | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| dimethyl sulfoxide | | sulfoxide;
volatile organic compound | alkylating agent;
antidote;
Escherichia coli metabolite;
geroprotector;
MRI contrast agent;
non-narcotic analgesic;
polar aprotic solvent;
radical scavenger | 1965 | 2017 | 30.0 | low | 0 | 5 | 0 | 1 | 4 | 0 |
| formaldehyde | | aldehyde;
one-carbon compound | allergen;
carcinogenic agent;
disinfectant;
EC 3.5.1.4 (amidase) inhibitor;
environmental contaminant;
Escherichia coli metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite | 1964 | 2022 | 34.3 | low | 0 | 5 | 0 | 1 | 2 | 1 |
| glycine | | alpha-amino acid;
amino acid zwitterion;
proteinogenic amino acid;
serine family amino acid | EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor;
fundamental metabolite;
hepatoprotective agent;
micronutrient;
neurotransmitter;
NMDA receptor agonist;
nutraceutical | 1986 | 2021 | 17.6 | low | 0 | 1 | 1 | 2 | 3 | 1 |
| glyceraldehyde | | aldotriose | fundamental metabolite | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| glycerol | | alditol;
triol | algal metabolite;
detergent;
Escherichia coli metabolite;
geroprotector;
human metabolite;
mouse metabolite;
osmolyte;
Saccharomyces cerevisiae metabolite;
solvent | 1970 | 2021 | 23.0 | low | 0 | 1 | 1 | 0 | 1 | 1 |
| glycolic acid | | 2-hydroxy monocarboxylic acid;
primary alcohol | keratolytic drug;
metabolite | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| glyoxylic acid | | 2-oxo monocarboxylic acid;
aldehydic acid | Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| glycocyamine | | guanidinoacetic acids;
zwitterion | bacterial metabolite;
human metabolite;
mouse metabolite;
nutraceutical;
rat metabolite | 1991 | 1991 | 33.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| hydrogen carbonate | | carbon oxoanion | cofactor;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite | 1967 | 1972 | 54.5 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| histamine | | aralkylamino compound;
imidazoles | human metabolite;
mouse metabolite;
neurotransmitter | 1955 | 2014 | 36.6 | low | 0 | 4 | 0 | 3 | 2 | 0 |
| hydrogen | | elemental hydrogen;
elemental molecule;
gas molecular entity | antioxidant;
electron donor;
food packaging gas;
fuel;
human metabolite | 1988 | 2023 | 14.5 | low | 0 | 1 | 1 | 2 | 4 | 2 |
| hydroquinone | | benzenediol;
hydroquinones | antioxidant;
carcinogenic agent;
cofactor;
Escherichia coli metabolite;
human xenobiotic metabolite;
mouse metabolite;
skin lightening agent | 2007 | 2015 | 13.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| hydroxylamine | | hydroxylamines | algal metabolite;
bacterial xenobiotic metabolite;
EC 1.1.3.13 (alcohol oxidase) inhibitor;
EC 4.2.1.22 (cystathionine beta-synthase) inhibitor;
EC 4.3.1.10 (serine-sulfate ammonia-lyase) inhibitor;
nitric oxide donor;
nucleophilic reagent | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| imidazole | | imidazole | | 2011 | 2012 | 12.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| indole | | indole;
polycyclic heteroarene | Escherichia coli metabolite | 2001 | 2012 | 18.3 | low | 0 | 0 | 0 | 2 | 1 | 0 |
| iodine | | diatomic iodine | nutrient | 1971 | 2013 | 32.2 | low | 0 | 2 | 0 | 0 | 2 | 0 |
| thioctic acid | | dithiolanes;
heterocyclic fatty acid;
thia fatty acid | fundamental metabolite;
geroprotector | 1993 | 2013 | 21.0 | low | 0 | 0 | 1 | 0 | 1 | 0 |
| methanol | | alkyl alcohol;
one-carbon compound;
primary alcohol;
volatile organic compound | amphiprotic solvent;
Escherichia coli metabolite;
fuel;
human metabolite;
mouse metabolite;
Mycoplasma genitalium metabolite | 1946 | 2022 | 41.0 | low | 1 | 22 | 2 | 9 | 2 | 1 |
| methanol | | alkyl alcohol;
one-carbon compound;
primary alcohol;
volatile organic compound | amphiprotic solvent;
Escherichia coli metabolite;
fuel;
human metabolite;
mouse metabolite;
Mycoplasma genitalium metabolite | 1946 | 2022 | 29.8 | low | 1 | 22 | 4 | 19 | 15 | 1 |
| inositol | | cyclitol;
hexol | | 1964 | 1973 | 55.5 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| melatonin | | acetamides;
tryptamines | anticonvulsant;
central nervous system depressant;
geroprotector;
hormone;
human metabolite;
immunological adjuvant;
mouse metabolite;
radical scavenger | 2008 | 2023 | 7.0 | low | 0 | 0 | 0 | 1 | 1 | 1 |
| croton oil | | N-acyl-hexosamine | | 1962 | 2001 | 51.2 | low | 0 | 4 | 0 | 1 | 0 | 0 |
| naphthalene | | naphthalenes;
ortho-fused bicyclic arene | apoptosis inhibitor;
carcinogenic agent;
environmental contaminant;
mouse metabolite;
plant metabolite;
volatile oil component | 1952 | 2023 | 16.8 | low | 1 | 14 | 26 | 74 | 85 | 12 |
| nickel | | metal allergen;
nickel group element atom | epitope;
micronutrient | 1979 | 2018 | 18.7 | low | 0 | 1 | 0 | 7 | 2 | 0 |
| niacinamide | | pyridine alkaloid;
pyridinecarboxamide;
vitamin B3 | anti-inflammatory agent;
antioxidant;
cofactor;
EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor;
EC 3.5.1.98 (histone deacetylase) inhibitor;
Escherichia coli metabolite;
geroprotector;
human urinary metabolite;
metabolite;
mouse metabolite;
neuroprotective agent;
Saccharomyces cerevisiae metabolite;
Sir2 inhibitor | 1998 | 2018 | 15.8 | low | 0 | 0 | 2 | 2 | 4 | 0 |
| nitrates | | monovalent inorganic anion;
nitrogen oxoanion;
reactive nitrogen species | | 1972 | 2023 | 15.1 | low | 0 | 2 | 2 | 9 | 3 | 6 |
| nitrites | | monovalent inorganic anion;
nitrogen oxoanion;
reactive nitrogen species | human metabolite | 1972 | 2023 | 18.2 | low | 0 | 1 | 1 | 8 | 1 | 2 |
| nitrous oxide | | gas molecular entity;
nitrogen oxide | analgesic;
bacterial metabolite;
food packaging gas;
food propellant;
general anaesthetic;
greenhouse gas;
inhalation anaesthetic;
NMDA receptor antagonist;
raising agent;
refrigerant;
vasodilator agent | 2009 | 2015 | 12.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| orotic acid | | pyrimidinemonocarboxylic acid | Escherichia coli metabolite;
metabolite;
mouse metabolite | 1970 | 1993 | 42.5 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| oxalic acid | | alpha,omega-dicarboxylic acid | algal metabolite;
human metabolite;
plant metabolite | 2009 | 2016 | 10.3 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| 4-aminobenzoic acid | | aminobenzoic acid;
aromatic amino-acid zwitterion | allergen;
Escherichia coli metabolite;
plant metabolite | 1962 | 2001 | 54.2 | low | 0 | 4 | 0 | 1 | 0 | 0 |
| 4-nitrophenol | | 4-nitrophenols | human xenobiotic metabolite;
mouse metabolite | 1988 | 2021 | 19.5 | low | 0 | 1 | 0 | 0 | 0 | 1 |
| palmitic acid | | long-chain fatty acid;
straight-chain saturated fatty acid | algal metabolite;
Daphnia magna metabolite;
EC 1.1.1.189 (prostaglandin-E2 9-reductase) inhibitor;
plant metabolite | 1991 | 2015 | 21.0 | low | 0 | 0 | 1 | 0 | 1 | 0 |
| parathion | | C-nitro compound;
organic thiophosphate;
organothiophosphate insecticide | acaricide;
agrochemical;
avicide;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
mouse metabolite | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| pentachlorophenol | | aromatic fungicide;
chlorophenol;
organochlorine pesticide;
pentachlorobenzenes | human xenobiotic metabolite | 1998 | 2023 | 12.3 | low | 0 | 0 | 1 | 5 | 7 | 1 |
| phenanthrene | | ortho-fused polycyclic arene;
ortho-fused tricyclic hydrocarbon;
phenanthrenes | environmental contaminant;
mouse metabolite | 1945 | 2024 | 17.5 | high | 4 | 169 | 125 | 731 | 834 | 118 |
| phenol | | phenols | antiseptic drug;
disinfectant;
human xenobiotic metabolite;
mouse metabolite | 1991 | 2022 | 16.9 | low | 0 | 0 | 3 | 7 | 3 | 2 |
| phenethylamine | | alkaloid;
aralkylamine;
phenylethylamine | Escherichia coli metabolite;
human metabolite;
mouse metabolite | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| phosphoric acid | | phosphoric acids | algal metabolite;
fertilizer;
human metabolite;
NMR chemical shift reference compound;
solvent | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| phosphoenolpyruvate | | carboxyalkyl phosphate;
monocarboxylic acid | fundamental metabolite | 1973 | 1974 | 50.7 | low | 0 | 3 | 0 | 0 | 0 | 0 |
| phosphorylcholine | | phosphocholines | allergen;
epitope;
hapten;
human metabolite;
mouse metabolite | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| phthalic acid | | benzenedicarboxylic acid | human xenobiotic metabolite | 1983 | 2016 | 18.1 | low | 0 | 1 | 0 | 6 | 3 | 0 |
| porphobilinogen | | aralkylamino compound;
dicarboxylic acid;
pyrroles | Escherichia coli metabolite;
metabolite;
mouse metabolite | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| propylene glycol | | glycol;
propane-1,2-diols | allergen;
human xenobiotic metabolite;
mouse metabolite;
protic solvent | 2004 | 2013 | 15.5 | low | 0 | 0 | 0 | 3 | 1 | 0 |
| propionic acid | | saturated fatty acid;
short-chain fatty acid | antifungal drug | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| pteridines | | azaarene;
mancude organic heterobicyclic parent;
ortho-fused heteroarene;
pteridines | | 1974 | 1974 | 50.0 | low | 1 | 1 | 0 | 0 | 0 | 0 |
| purine | | purine | | 1964 | 2020 | 32.0 | low | 0 | 1 | 0 | 0 | 1 | 0 |
| pyridine | | azaarene;
mancude organic heteromonocyclic parent;
monocyclic heteroarene;
pyridines | environmental contaminant;
NMR chemical shift reference compound | 1965 | 2013 | 28.2 | low | 0 | 1 | 1 | 2 | 1 | 0 |
| pyridoxal phosphate | | methylpyridines;
monohydroxypyridine;
pyridinecarbaldehyde;
vitamin B6 phosphate | coenzyme;
cofactor;
EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| pyridoxine | | hydroxymethylpyridine;
methylpyridines;
monohydroxypyridine;
vitamin B6 | cofactor;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite | 2001 | 2015 | 16.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| pyruvic acid | | 2-oxo monocarboxylic acid | cofactor;
fundamental metabolite | 2000 | 2010 | 20.3 | low | 0 | 0 | 1 | 2 | 0 | 0 |
| quinolinic acid | | pyridinedicarboxylic acid | Escherichia coli metabolite;
human metabolite;
mouse metabolite;
NMDA receptor agonist | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 3 | 0 | 0 |
| thiosulfates | | divalent inorganic anion;
sulfur oxide;
sulfur oxoanion | human metabolite | 2004 | 2022 | 11.0 | low | 0 | 0 | 0 | 1 | 0 | 1 |
| sarcosine | | N-alkylglycine zwitterion;
N-alkylglycine;
N-methyl-amino acid;
N-methylglycines | Escherichia coli metabolite;
glycine receptor agonist;
glycine transporter 1 inhibitor;
human metabolite;
mouse metabolite | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| sulfites | | divalent inorganic anion;
sulfur oxide;
sulfur oxoanion | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| spermidine | | polyazaalkane;
triamine | autophagy inducer;
fundamental metabolite;
geroprotector | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| succinic acid | | alpha,omega-dicarboxylic acid;
C4-dicarboxylic acid | anti-ulcer drug;
fundamental metabolite;
micronutrient;
nutraceutical;
radiation protective agent | 2008 | 2019 | 11.0 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| sulfuric acid | | sulfur oxoacid | catalyst | 2009 | 2018 | 10.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| sulfur dioxide | | sulfur oxide | Escherichia coli metabolite;
food bleaching agent;
refrigerant | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| taurine | | amino sulfonic acid;
zwitterion | antioxidant;
Escherichia coli metabolite;
glycine receptor agonist;
human metabolite;
mouse metabolite;
nutrient;
radical scavenger;
Saccharomyces cerevisiae metabolite | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| thiamine | | primary alcohol;
vitamin B1 | Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| thymine | | pyrimidine nucleobase;
pyrimidone | Escherichia coli metabolite;
human metabolite;
mouse metabolite | 1964 | 1986 | 51.2 | low | 0 | 4 | 0 | 0 | 0 | 0 |
| toluene | | methylbenzene;
toluenes;
volatile organic compound | cholinergic antagonist;
fuel additive;
neurotoxin;
non-polar solvent | 1964 | 2022 | 26.4 | low | 0 | 5 | 2 | 4 | 5 | 2 |
| trimethyloxamine | | tertiary amine oxide | Escherichia coli metabolite;
metabolite;
osmolyte | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| uracil | | pyrimidine nucleobase;
pyrimidone | allergen;
Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
prodrug;
Saccharomyces cerevisiae metabolite | 1966 | 2006 | 47.8 | low | 0 | 4 | 0 | 1 | 0 | 0 |
| uric acid | | uric acid | Escherichia coli metabolite;
human metabolite;
mouse metabolite | 2009 | 2021 | 9.0 | low | 0 | 0 | 0 | 1 | 0 | 1 |
| urea | | isourea;
monocarboxylic acid amide;
one-carbon compound | Daphnia magna metabolite;
Escherichia coli metabolite;
fertilizer;
flour treatment agent;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite | 1963 | 1993 | 49.9 | low | 0 | 6 | 1 | 0 | 0 | 0 |
| isopentenyl pyrophosphate | | prenol phosphate | antigen;
antioxidant;
epitope;
Escherichia coli metabolite;
mouse metabolite;
phosphoantigen | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| 8-hydroxy-2-(di-n-propylamino)tetralin | | phenols;
tertiary amino compound;
tetralins | serotonergic antagonist | 1986 | 1986 | 38.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| huperzine a | | quinolone | | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| menthol | | p-menthane monoterpenoid;
secondary alcohol | volatile oil component | 1968 | 2007 | 32.0 | low | 0 | 1 | 0 | 2 | 0 | 0 |
| 1,10-phenanthroline | | phenanthroline | EC 2.7.1.1 (hexokinase) inhibitor;
EC 3.4.19.3 (pyroglutamyl-peptidase I) inhibitor | 1951 | 2014 | 35.5 | low | 0 | 4 | 1 | 4 | 2 | 0 |
| 1,2-dimethylhydrazine | | hydrazines | alkylating agent;
carcinogenic agent | 1994 | 1994 | 30.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| 1,5-dihydroxyisoquinoline | | isoquinolinol | EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor | 1995 | 1995 | 29.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| pk 11195 | | aromatic amide;
isoquinolines;
monocarboxylic acid amide;
monochlorobenzenes | antineoplastic agent | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 1-aminobenzotriazole | | | | 2003 | 2014 | 17.3 | low | 0 | 0 | 0 | 2 | 1 | 0 |
| 1-anilino-8-naphthalenesulfonate | | aminonaphthalene;
naphthalenesulfonic acid | fluorescent probe | 2005 | 2022 | 12.6 | low | 0 | 0 | 0 | 5 | 2 | 1 |
| 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine | | methylpyridines;
phenylpyridine;
tetrahydropyridine | neurotoxin | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 14,15-epoxy-5,8,11-eicosatrienoic acid | | long-chain fatty acid | | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| 1h-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one | | oxadiazoloquinoxaline | EC 4.6.1.2 (guanylate cyclase) inhibitor | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 2,2'-dipyridyl | | bipyridine | chelator;
ferroptosis inhibitor | 1958 | 2014 | 25.5 | low | 0 | 1 | 1 | 2 | 2 | 0 |
| 2,4,6-tribromophenol | | bromophenol | environmental contaminant;
fungicide;
marine metabolite | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 2,4-dichlorophenoxyacetic acid | | chlorophenoxyacetic acid;
dichlorobenzene | agrochemical;
defoliant;
EC 1.1.1.25 (shikimate dehydrogenase) inhibitor;
environmental contaminant;
phenoxy herbicide;
synthetic auxin | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 2,4-dinitrophenol | | dinitrophenol | allergen;
antiseptic drug;
bacterial xenobiotic metabolite;
geroprotector;
oxidative phosphorylation inhibitor | 2000 | 2010 | 18.3 | low | 0 | 0 | 1 | 2 | 0 | 0 |
| 2-aminofluorene | | | | 1976 | 1976 | 48.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| mercaptoethanol | | alkanethiol;
primary alcohol | geroprotector | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 2-aminoethoxydiphenyl borate | | organoboron compound;
primary amino compound | calcium channel blocker;
IP3 receptor antagonist;
potassium channel opener | 2019 | 2021 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| 3-aminobenzamide | | benzamides;
substituted aniline | EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor | 1995 | 2020 | 17.4 | low | 0 | 0 | 3 | 12 | 4 | 0 |
| 3-methoxytyramine | | monomethoxybenzene;
phenols;
phenylethylamine;
primary amino compound | biomarker;
human blood serum metabolite;
human urinary metabolite | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 3-methylcholanthrene | | ortho- and peri-fused polycyclic arene | aryl hydrocarbon receptor agonist;
carcinogenic agent | 1945 | 2003 | 49.2 | low | 0 | 58 | 2 | 1 | 0 | 0 |
| 3-nitropropionic acid | | C-nitro compound | antimycobacterial drug;
EC 1.3.5.1 [succinate dehydrogenase (quinone)] inhibitor;
mycotoxin;
neurotoxin | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 4-amino-1,8-naphthalimide | | benzoisoquinoline;
dicarboximide | | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| 4-aminopyridine | | aminopyridine;
aromatic amine | avicide;
orphan drug;
potassium channel blocker | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| homovanillic acid | | guaiacols;
monocarboxylic acid | human metabolite;
mouse metabolite | 2003 | 2019 | 13.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| 4-nonylphenol | | phenols | environmental contaminant | 2010 | 2014 | 12.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| phenytoin | | imidazolidine-2,4-dione | anticonvulsant;
drug allergen;
sodium channel blocker;
teratogenic agent | 1972 | 1972 | 52.0 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| 5,8,11,14-eicosatetraynoic acid | | long-chain fatty acid | | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 5,8,11-eicosatriynoic acid | | acetylenic fatty acid;
icosanoid;
long-chain fatty acid;
polyunsaturated fatty acid | EC 1.13.11.31 (arachidonate 12-lipoxygenase) inhibitor | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 5-hydroxydecanoate | | medium-chain fatty acid | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| phenanthridone | | lactam;
phenanthridines | EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor;
immunosuppressive agent;
mutagen | 1985 | 2023 | 17.6 | high | 0 | 2 | 7 | 15 | 16 | 1 |
| tacrine | | acridines;
aromatic amine | EC 3.1.1.7 (acetylcholinesterase) inhibitor | 1995 | 2012 | 20.5 | low | 0 | 0 | 1 | 0 | 1 | 0 |
| aa 861 | | 1,4-benzoquinones;
acetylenic compound;
primary alcohol | EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor;
ferroptosis inhibitor | 1991 | 1999 | 27.7 | low | 0 | 0 | 3 | 0 | 0 | 0 |
| acetaminophen | | acetamides;
phenols | antipyretic;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
cyclooxygenase 3 inhibitor;
environmental contaminant;
ferroptosis inducer;
geroprotector;
hepatotoxic agent;
human blood serum metabolite;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
xenobiotic | 1969 | 2018 | 23.8 | low | 1 | 1 | 1 | 1 | 2 | 0 |
| acetazolamide | | monocarboxylic acid amide;
sulfonamide;
thiadiazoles | anticonvulsant;
diuretic;
EC 4.2.1.1 (carbonic anhydrase) inhibitor | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| acridone | | acridines;
cyclic ketone | | 1995 | 2008 | 22.5 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| 5-aminoisoquinolinone | | isoquinolines | | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| albendazole | | aryl sulfide;
benzimidazoles;
benzimidazolylcarbamate fungicide;
carbamate ester | anthelminthic drug;
microtubule-destabilising agent;
tubulin modulator | 1993 | 1993 | 31.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| alendronate | | 1,1-bis(phosphonic acid);
primary amino compound | bone density conservation agent;
EC 2.5.1.1 (dimethylallyltranstransferase) inhibitor | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| amantadine | | adamantanes;
primary aliphatic amine | analgesic;
antiparkinson drug;
antiviral drug;
dopaminergic agent;
NMDA receptor antagonist;
non-narcotic analgesic | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| ambroxol | | aromatic amine | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| pimagedine | | guanidines;
one-carbon compound | EC 1.14.13.39 (nitric oxide synthase) inhibitor;
EC 1.4.3.4 (monoamine oxidase) inhibitor | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| theophylline | | dimethylxanthine | adenosine receptor antagonist;
anti-asthmatic drug;
anti-inflammatory agent;
bronchodilator agent;
drug metabolite;
EC 3.1.4.* (phosphoric diester hydrolase) inhibitor;
fungal metabolite;
human blood serum metabolite;
immunomodulator;
muscle relaxant;
vasodilator agent | 1962 | 2009 | 36.8 | low | 0 | 2 | 1 | 1 | 0 | 0 |
| amobarbital | | barbiturates | | 1974 | 1974 | 50.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| amodiaquine | | aminoquinoline;
organochlorine compound;
phenols;
secondary amino compound;
tertiary amino compound | anticoronaviral agent;
antimalarial;
drug allergen;
EC 2.1.1.8 (histamine N-methyltransferase) inhibitor;
non-steroidal anti-inflammatory drug;
prodrug | 1972 | 2010 | 29.4 | low | 2 | 7 | 9 | 6 | 0 | 0 |
| 9-anthroic acid | | anthroic acid | | 2001 | 2012 | 17.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| anthralin | | anthracenes | antipsoriatic | 1975 | 2005 | 34.0 | low | 0 | 1 | 0 | 1 | 0 | 0 |
| antipyrine | | pyrazolone | antipyretic;
cyclooxygenase 3 inhibitor;
environmental contaminant;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
xenobiotic | 1974 | 1990 | 42.0 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| aristolochic acid i | | aristolochic acids;
aromatic ether;
C-nitro compound;
cyclic acetal;
monocarboxylic acid;
organic heterotetracyclic compound | carcinogenic agent;
metabolite;
mutagen;
nephrotoxin;
toxin | 1961 | 2015 | 29.9 | medium | 1 | 44 | 94 | 44 | 2 | 0 |
| aristolochic acid i | | aristolochic acids;
aromatic ether;
C-nitro compound;
cyclic acetal;
monocarboxylic acid;
organic heterotetracyclic compound | carcinogenic agent;
metabolite;
mutagen;
nephrotoxin;
toxin | 2002 | 2006 | 20.9 | low | 0 | 0 | 0 | 7 | 0 | 0 |
| aspirin | | benzoic acids;
phenyl acetates;
salicylates | anticoagulant;
antipyretic;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
drug allergen;
EC 1.1.1.188 (prostaglandin-F synthase) inhibitor;
geroprotector;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
plant activator;
platelet aggregation inhibitor;
prostaglandin antagonist;
teratogenic agent | 1972 | 2017 | 24.3 | low | 1 | 2 | 0 | 3 | 2 | 0 |
| atrazine | | chloro-1,3,5-triazine;
diamino-1,3,5-triazine | environmental contaminant;
herbicide;
xenobiotic | 2001 | 2018 | 14.1 | low | 0 | 0 | 0 | 8 | 8 | 0 |
| barbital | | barbiturates | drug allergen | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| bay-k-8644 | | (trifluoromethyl)benzenes;
C-nitro compound;
dihydropyridine;
methyl ester | | 2014 | 2020 | 7.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| benzamide | | benzamides | | 1998 | 2014 | 18.8 | low | 0 | 0 | 1 | 3 | 2 | 0 |
| benzo(a)pyrene | | ortho- and peri-fused polycyclic arene | carcinogenic agent;
mouse metabolite | 1962 | 2024 | 18.7 | low | 0 | 26 | 19 | 43 | 57 | 9 |
| bepridil | | pyrrolidines;
tertiary amine | anti-arrhythmia drug;
antihypertensive agent;
calcium channel blocker;
vasodilator agent | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| berberine | | alkaloid antibiotic;
berberine alkaloid;
botanical anti-fungal agent;
organic heteropentacyclic compound | antilipemic drug;
antineoplastic agent;
antioxidant;
EC 1.1.1.141 [15-hydroxyprostaglandin dehydrogenase (NAD(+))] inhibitor;
EC 1.1.1.21 (aldehyde reductase) inhibitor;
EC 1.13.11.52 (indoleamine 2,3-dioxygenase) inhibitor;
EC 1.21.3.3 (reticuline oxidase) inhibitor;
EC 2.1.1.116 [3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase] inhibitor;
EC 2.1.1.122 [(S)-tetrahydroprotoberberine N-methyltransferase] inhibitor;
EC 2.7.11.10 (IkappaB kinase) inhibitor;
EC 3.1.1.4 (phospholipase A2) inhibitor;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
EC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitor;
EC 3.4.14.5 (dipeptidyl-peptidase IV) inhibitor;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
geroprotector;
hypoglycemic agent;
metabolite;
potassium channel blocker | 2000 | 2017 | 14.4 | low | 0 | 0 | 1 | 1 | 3 | 0 |
| beta-naphthoflavone | | extended flavonoid;
naphtho-gamma-pyrone;
organic heterotricyclic compound | aryl hydrocarbon receptor agonist | 1985 | 2003 | 31.0 | low | 0 | 5 | 1 | 3 | 0 | 0 |
| bicalutamide | | (trifluoromethyl)benzenes;
monocarboxylic acid amide;
monofluorobenzenes;
nitrile;
sulfone;
tertiary alcohol | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| bisbenzimidazole | | bibenzimidazole;
N-methylpiperazine | anthelminthic drug;
fluorochrome | 2008 | 2010 | 15.0 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| buformin | | biguanides | antineoplastic agent;
antiviral agent;
geroprotector;
hypoglycemic agent;
radiosensitizing agent | 1988 | 1988 | 36.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| butacaine | | benzoate ester | | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| cacodylic acid | | organoarsenic compound | xenobiotic metabolite | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| caffeine | | purine alkaloid;
trimethylxanthine | adenosine A2A receptor antagonist;
adenosine receptor antagonist;
adjuvant;
central nervous system stimulant;
diuretic;
EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor;
EC 3.1.4.* (phosphoric diester hydrolase) inhibitor;
environmental contaminant;
food additive;
fungal metabolite;
geroprotector;
human blood serum metabolite;
mouse metabolite;
mutagen;
plant metabolite;
psychotropic drug;
ryanodine receptor agonist;
xenobiotic | 1964 | 2012 | 27.7 | low | 1 | 3 | 2 | 5 | 2 | 0 |
| verapamil | | aromatic ether;
nitrile;
polyether;
tertiary amino compound | | 1995 | 2017 | 19.0 | low | 0 | 0 | 5 | 3 | 3 | 0 |
| camphor, (+-)-isomer | | bornane monoterpenoid;
cyclic monoterpene ketone | plant metabolite | 1974 | 1975 | 49.5 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| cannabinol | | dibenzopyran | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| carbamazepine | | dibenzoazepine;
ureas | analgesic;
anticonvulsant;
antimanic drug;
drug allergen;
EC 3.5.1.98 (histone deacetylase) inhibitor;
environmental contaminant;
glutamate transporter activator;
mitogen;
non-narcotic analgesic;
sodium channel blocker;
xenobiotic | 2011 | 2013 | 12.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| carisoprodol | | carbamate ester | muscle relaxant | 1971 | 1971 | 53.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| carbonyl cyanide m-chlorophenyl hydrazone | | hydrazone;
monochlorobenzenes;
nitrile | antibacterial agent;
geroprotector;
ionophore | 1999 | 2001 | 24.0 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| celecoxib | | organofluorine compound;
pyrazoles;
sulfonamide;
toluenes | cyclooxygenase 2 inhibitor;
geroprotector;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug | 2010 | 2016 | 11.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| cetyltrimethylammonium ion | | quaternary ammonium ion | | 2005 | 2019 | 12.8 | low | 0 | 0 | 0 | 2 | 2 | 0 |
| cetylpyridinium | | pyridinium ion | | 1974 | 2014 | 30.0 | low | 0 | 1 | 0 | 0 | 1 | 0 |
| chelerythrine | | benzophenanthridine alkaloid;
organic cation | antibacterial agent;
antineoplastic agent;
EC 2.7.11.13 (protein kinase C) inhibitor | 1989 | 1989 | 35.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| chloroquine | | aminoquinoline;
organochlorine compound;
secondary amino compound;
tertiary amino compound | anticoronaviral agent;
antimalarial;
antirheumatic drug;
autophagy inhibitor;
dermatologic drug | 1969 | 2020 | 29.4 | low | 16 | 21 | 71 | 13 | 7 | 0 |
| chloroxine | | monohydroxyquinoline;
organochlorine compound | antibacterial agent;
antifungal drug;
antiseborrheic | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| chlorpheniramine | | monochlorobenzenes;
pyridines;
tertiary amino compound | anti-allergic agent;
antidepressant;
antipruritic drug;
H1-receptor antagonist;
histamine antagonist;
serotonin uptake inhibitor | 1994 | 1994 | 30.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| chlorpromazine | | organochlorine compound;
phenothiazines;
tertiary amine | anticoronaviral agent;
antiemetic;
dopaminergic antagonist;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
phenothiazine antipsychotic drug | 1968 | 2000 | 42.6 | low | 0 | 3 | 2 | 0 | 0 | 0 |
| chlorpyrifos | | chloropyridine;
organic thiophosphate | acaricide;
agrochemical;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
environmental contaminant;
insecticide;
xenobiotic | 2006 | 2019 | 11.0 | low | 0 | 0 | 0 | 2 | 2 | 0 |
| chlorzoxazone | | 1,3-benzoxazoles;
heteroaryl hydroxy compound;
organochlorine compound | muscle relaxant;
sedative | 1996 | 1996 | 28.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| ciprofloxacin | | aminoquinoline;
cyclopropanes;
fluoroquinolone antibiotic;
N-arylpiperazine;
quinolinemonocarboxylic acid;
quinolone antibiotic;
quinolone;
zwitterion | antibacterial drug;
antiinfective agent;
antimicrobial agent;
DNA synthesis inhibitor;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
environmental contaminant;
topoisomerase IV inhibitor;
xenobiotic | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| platinum tetrachloride | | platinum coordination entity | catalyst;
reagent | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| clenbuterol | | amino alcohol;
dichlorobenzene;
ethanolamines;
primary arylamine;
secondary amino compound;
substituted aniline | beta-adrenergic agonist;
bronchodilator agent;
sympathomimetic agent | 1987 | 1987 | 37.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| clioquinol | | monohydroxyquinoline;
organochlorine compound;
organoiodine compound | antibacterial agent;
antifungal agent;
antimicrobial agent;
antineoplastic agent;
antiprotozoal drug;
chelator;
copper chelator | 1958 | 1974 | 56.4 | low | 0 | 5 | 0 | 0 | 0 | 0 |
| clofazimine | | monochlorobenzenes;
phenazines | dye;
leprostatic drug;
non-steroidal anti-inflammatory drug | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| clofilium | | benzenes;
organic amino compound | | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 4-cresol | | cresol | Escherichia coli metabolite;
human metabolite;
uremic toxin | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| cyproheptadine | | piperidines;
tertiary amine | anti-allergic agent;
antipruritic drug;
gastrointestinal drug;
H1-receptor antagonist;
serotonergic antagonist | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| dapi | | indoles | fluorochrome | 2001 | 2017 | 14.6 | low | 0 | 0 | 0 | 3 | 2 | 0 |
| dapsone | | substituted aniline;
sulfone | anti-inflammatory drug;
antiinfective agent;
antimalarial;
leprostatic drug | 1974 | 1976 | 49.0 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| debrisoquin | | carboxamidine;
isoquinolines | adrenergic agent;
antihypertensive agent;
human metabolite;
sympatholytic agent | 1998 | 1998 | 26.0 | low | 1 | 0 | 1 | 0 | 0 | 0 |
| deferoxamine | | acyclic desferrioxamine | bacterial metabolite;
ferroptosis inhibitor;
iron chelator;
siderophore | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| amphetamine | | primary amine | | 1974 | 1978 | 48.0 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| diazepam | | 1,4-benzodiazepinone;
organochlorine compound | anticonvulsant;
anxiolytic drug;
environmental contaminant;
sedative;
xenobiotic | 1991 | 2004 | 24.8 | low | 0 | 0 | 2 | 2 | 0 | 0 |
| diazoxide | | benzothiadiazine;
organochlorine compound;
sulfone | antihypertensive agent;
beta-adrenergic agonist;
bronchodilator agent;
cardiotonic drug;
diuretic;
K-ATP channel agonist;
sodium channel blocker;
sympathomimetic agent;
vasodilator agent | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| dibenzothiophene | | dibenzothiophenes;
mancude organic heterotricyclic parent | keratolytic drug | 1990 | 2017 | 16.2 | low | 0 | 0 | 2 | 2 | 5 | 0 |
| methylene bromide | | bromohydrocarbon;
bromomethanes | algal metabolite;
marine metabolite | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| dibutyl phthalate | | diester;
phthalate ester | EC 3.2.1.20 (alpha-glucosidase) inhibitor;
environmental contaminant;
metabolite;
plasticiser;
teratogenic agent | 1996 | 2016 | 16.8 | low | 0 | 0 | 2 | 0 | 3 | 0 |
| diclofenac | | amino acid;
aromatic amine;
dichlorobenzene;
monocarboxylic acid;
secondary amino compound | antipyretic;
drug allergen;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
environmental contaminant;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
xenobiotic | 1997 | 2000 | 25.5 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| dichlorodiphenyl dichloroethylene | | chlorophenylethylene;
monochlorobenzenes | human xenobiotic metabolite;
persistent organic pollutant | 2000 | 2022 | 14.0 | low | 0 | 0 | 1 | 1 | 0 | 1 |
| ddt | | benzenoid aromatic compound;
chlorophenylethane;
monochlorobenzenes;
organochlorine insecticide | bridged diphenyl acaricide;
carcinogenic agent;
endocrine disruptor;
persistent organic pollutant | 1968 | 2015 | 25.9 | low | 0 | 4 | 1 | 2 | 5 | 0 |
| dichlorvos | | alkenyl phosphate;
dialkyl phosphate;
organochlorine acaricide;
organophosphate insecticide | anthelminthic drug;
antibacterial agent;
antifungal agent;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| diethyl pyrocarbonate | | acyclic carboxylic anhydride | | 1991 | 1994 | 31.5 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| diethylcarbamazine | | N-carbamoylpiperazine;
N-methylpiperazine | | 1994 | 1994 | 30.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| pentetic acid | | pentacarboxylic acid | copper chelator | 1996 | 2001 | 25.5 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| dipyridamole | | piperidines;
pyrimidopyrimidine;
tertiary amino compound;
tetrol | adenosine phosphodiesterase inhibitor;
EC 3.5.4.4 (adenosine deaminase) inhibitor;
platelet aggregation inhibitor;
vasodilator agent | 1981 | 1981 | 43.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| disulfiram | | organic disulfide;
organosulfur acaricide | angiogenesis inhibitor;
antineoplastic agent;
apoptosis inducer;
EC 1.2.1.3 [aldehyde dehydrogenase (NAD(+))] inhibitor;
EC 3.1.1.1 (carboxylesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
ferroptosis inducer;
fungicide;
NF-kappaB inhibitor | 1985 | 1985 | 39.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| diuron | | 3-(3,4-substituted-phenyl)-1,1-dimethylurea;
dichlorobenzene | environmental contaminant;
mitochondrial respiratory-chain inhibitor;
photosystem-II inhibitor;
urea herbicide;
xenobiotic | 1974 | 2009 | 24.0 | low | 0 | 1 | 0 | 3 | 0 | 0 |
| valproic acid | | branched-chain fatty acid;
branched-chain saturated fatty acid | anticonvulsant;
antimanic drug;
EC 3.5.1.98 (histone deacetylase) inhibitor;
GABA agent;
neuroprotective agent;
psychotropic drug;
teratogenic agent | 1991 | 1991 | 33.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| 2,3-dimethoxy-1,4-naphthoquinone | | 1,4-naphthoquinones | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| domperidone | | benzimidazoles;
heteroarylpiperidine | antiemetic;
dopaminergic antagonist | 1991 | 1991 | 33.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| emodin | | trihydroxyanthraquinone | antineoplastic agent;
laxative;
plant metabolite;
tyrosine kinase inhibitor | 2003 | 2021 | 11.7 | low | 0 | 0 | 0 | 2 | 3 | 1 |
| endosulfan | | cyclic sulfite ester;
cyclodiene organochlorine insecticide | acaricide;
agrochemical;
GABA-gated chloride channel antagonist;
persistent organic pollutant | 2017 | 2018 | 6.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| erythrosine | | | | 1966 | 1966 | 58.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| ethacrynic acid | | aromatic ether;
aromatic ketone;
dichlorobenzene;
monocarboxylic acid | EC 2.5.1.18 (glutathione transferase) inhibitor;
ion transport inhibitor;
loop diuretic | 1990 | 1991 | 33.5 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| etodolac | | monocarboxylic acid;
organic heterotricyclic compound | antipyretic;
cyclooxygenase 2 inhibitor;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| felodipine | | dichlorobenzene;
dihydropyridine;
ethyl ester;
methyl ester | anti-arrhythmia drug;
antihypertensive agent;
calcium channel blocker;
vasodilator agent | 1995 | 1995 | 29.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| fenfluramine | | (trifluoromethyl)benzenes;
secondary amino compound | appetite depressant;
serotonergic agonist;
serotonin uptake inhibitor | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| fenofibrate | | aromatic ether;
chlorobenzophenone;
isopropyl ester;
monochlorobenzenes | antilipemic drug;
environmental contaminant;
geroprotector;
xenobiotic | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| fexofenadine | | piperidines;
tertiary amine | anti-allergic agent;
H1-receptor antagonist | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| fluconazole | | conazole antifungal drug;
difluorobenzene;
tertiary alcohol;
triazole antifungal drug | environmental contaminant;
P450 inhibitor;
xenobiotic | 1988 | 2012 | 21.0 | low | 1 | 1 | 0 | 1 | 1 | 0 |
| flufenamic acid | | aromatic amino acid;
organofluorine compound | antipyretic;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug | 2011 | 2013 | 11.8 | low | 0 | 0 | 0 | 0 | 4 | 0 |
| flunitrazepam | | 1,4-benzodiazepinone;
C-nitro compound;
monofluorobenzenes | anxiolytic drug;
GABAA receptor agonist;
sedative | 1991 | 2004 | 26.5 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| fluorouracil | | nucleobase analogue;
organofluorine compound | antimetabolite;
antineoplastic agent;
environmental contaminant;
immunosuppressive agent;
radiosensitizing agent;
xenobiotic | 1970 | 2021 | 18.4 | low | 0 | 2 | 0 | 3 | 4 | 1 |
| fluoxetine | | (trifluoromethyl)benzenes;
aromatic ether;
secondary amino compound | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| flurbiprofen | | fluorobiphenyl;
monocarboxylic acid | antipyretic;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug | 1997 | 1997 | 27.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| furazolidone | | nitrofuran antibiotic;
oxazolidines | antibacterial drug;
antiinfective agent;
antitrichomonal drug;
EC 1.4.3.4 (monoamine oxidase) inhibitor | 1974 | 1974 | 50.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| furosemide | | chlorobenzoic acid;
furans;
sulfonamide | environmental contaminant;
loop diuretic;
xenobiotic | 2010 | 2021 | 8.0 | low | 0 | 0 | 0 | 1 | 4 | 1 |
| gentamicin | | | | 1997 | 2003 | 24.0 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| glutaral | | dialdehyde | cross-linking reagent;
disinfectant;
fixative | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| glyburide | | monochlorobenzenes;
N-sulfonylurea | anti-arrhythmia drug;
EC 2.7.1.33 (pantothenate kinase) inhibitor;
EC 3.6.3.49 (channel-conductance-controlling ATPase) inhibitor;
hypoglycemic agent | 1993 | 2021 | 14.6 | low | 0 | 0 | 1 | 1 | 2 | 1 |
| glyphosate | | glycine derivative;
phosphonic acid | agrochemical;
EC 2.5.1.19 (3-phosphoshikimate 1-carboxyvinyltransferase) inhibitor;
herbicide | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| gossypol | | | | 1992 | 2014 | 19.3 | low | 0 | 0 | 1 | 1 | 1 | 0 |
| guaifenesin | | methoxybenzenes | | 2015 | 2020 | 6.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| guanidine | | carboxamidine;
guanidines;
one-carbon compound | | 1947 | 1998 | 51.5 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| bis(2-guanidinoethyl)disulfide | | | | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 1-(5-isoquinolinesulfonyl)-2-methylpiperazine | | isoquinolines;
N-sulfonylpiperazine | EC 2.7.11.13 (protein kinase C) inhibitor | 1993 | 1993 | 31.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| haloperidol | | aromatic ketone;
hydroxypiperidine;
monochlorobenzenes;
organofluorine compound;
tertiary alcohol | antidyskinesia agent;
antiemetic;
dopaminergic antagonist;
first generation antipsychotic;
serotonergic antagonist | 1977 | 1977 | 47.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| heptachlor | | cyclodiene organochlorine insecticide | agrochemical;
antibacterial agent;
antifungal agent;
GABA-gated chloride channel antagonist;
persistent organic pollutant | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| hexamethonium | | quaternary ammonium salt | | 1998 | 1998 | 26.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| hexestrol | | stilbenoid | | 1964 | 1964 | 60.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| hexobarbital | | barbiturates | | 1978 | 1978 | 46.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| ethidium | | phenanthridines | fluorochrome;
intercalator | 1976 | 1999 | 35.3 | low | 0 | 1 | 2 | 0 | 0 | 0 |
| hydroxyurea | | one-carbon compound;
ureas | antimetabolite;
antimitotic;
antineoplastic agent;
DNA synthesis inhibitor;
EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor;
genotoxin;
immunomodulator;
radical scavenger;
teratogenic agent | 1977 | 2013 | 29.0 | low | 0 | 1 | 0 | 0 | 1 | 0 |
| hypericin | | | | 1979 | 2000 | 34.5 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| ibuprofen | | monocarboxylic acid | antipyretic;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
drug allergen;
environmental contaminant;
geroprotector;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
radical scavenger;
xenobiotic | 1998 | 2002 | 23.7 | low | 0 | 0 | 1 | 2 | 0 | 0 |
| lidocaine | | benzenes;
monocarboxylic acid amide;
tertiary amino compound | anti-arrhythmia drug;
drug allergen;
environmental contaminant;
local anaesthetic;
xenobiotic | 1987 | 1987 | 37.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| idebenone | | 1,4-benzoquinones;
primary alcohol | antioxidant;
ferroptosis inhibitor | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| indomethacin | | aromatic ether;
indole-3-acetic acids;
monochlorobenzenes;
N-acylindole | analgesic;
drug metabolite;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
environmental contaminant;
gout suppressant;
non-steroidal anti-inflammatory drug;
xenobiotic metabolite;
xenobiotic | 1977 | 2016 | 29.8 | low | 0 | 3 | 4 | 2 | 1 | 0 |
| iproniazid | | carbohydrazide;
pyridines | | 1969 | 1969 | 55.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| avapro | | azaspiro compound;
biphenylyltetrazole | angiotensin receptor antagonist;
antihypertensive agent;
environmental contaminant;
xenobiotic | 2012 | 2022 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| isoniazid | | carbohydrazide | antitubercular agent;
drug allergen | 1964 | 1974 | 55.0 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| isoniazid | | carbohydrazide | antitubercular agent;
drug allergen | 1964 | 2017 | 39.0 | low | 0 | 2 | 0 | 0 | 1 | 0 |
| 2-propanol | | secondary alcohol;
secondary fatty alcohol | protic solvent | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| isoproterenol | | catechols;
secondary alcohol;
secondary amino compound | beta-adrenergic agonist;
bronchodilator agent;
cardiotonic drug;
sympathomimetic agent | 2009 | 2019 | 10.4 | low | 0 | 0 | 0 | 1 | 4 | 0 |
| juglone | | hydroxy-1,4-naphthoquinone | geroprotector;
herbicide;
reactive oxygen species generator | 1992 | 1996 | 30.0 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| ketoconazole | | dichlorobenzene;
dioxolane;
ether;
imidazoles;
N-acylpiperazine;
N-arylpiperazine | | 1988 | 2020 | 18.1 | low | 1 | 1 | 3 | 5 | 4 | 0 |
| ketoprofen | | benzophenones;
oxo monocarboxylic acid | antipyretic;
drug allergen;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
environmental contaminant;
non-steroidal anti-inflammatory drug;
xenobiotic | 1998 | 1998 | 26.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| kinetin | | 6-aminopurines;
furans | cytokinin;
geroprotector | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| leflunomide | | (trifluoromethyl)benzenes;
isoxazoles;
monocarboxylic acid amide | antineoplastic agent;
antiparasitic agent;
EC 1.3.98.1 [dihydroorotate oxidase (fumarate)] inhibitor;
EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor;
hepatotoxic agent;
immunosuppressive agent;
non-steroidal anti-inflammatory drug;
prodrug;
pyrimidine synthesis inhibitor;
tyrosine kinase inhibitor | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one | | chromones;
morpholines;
organochlorine compound | autophagy inhibitor;
EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor;
geroprotector | 2004 | 2020 | 13.8 | low | 0 | 0 | 0 | 5 | 3 | 0 |
| malathion | | diester;
ethyl ester;
organic thiophosphate | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| mechlorethamine | | nitrogen mustard;
organochlorine compound | alkylating agent | 1994 | 1994 | 30.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| memantine | | adamantanes;
primary aliphatic amine | antidepressant;
antiparkinson drug;
dopaminergic agent;
neuroprotective agent;
NMDA receptor antagonist | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| vitamin k 3 | | 1,4-naphthoquinones;
vitamin K | angiogenesis inhibitor;
antineoplastic agent;
EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor;
human urinary metabolite;
nutraceutical | 2002 | 2010 | 18.0 | low | 0 | 0 | 0 | 3 | 0 | 0 |
| meperidine | | ethyl ester;
piperidinecarboxylate ester;
tertiary amino compound | antispasmodic drug;
kappa-opioid receptor agonist;
mu-opioid receptor agonist;
opioid analgesic | 1969 | 1971 | 54.0 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| 2-mercaptoethylguanidine | | | | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| metformin | | guanidines | environmental contaminant;
geroprotector;
hypoglycemic agent;
xenobiotic | 2014 | 2021 | 5.3 | low | 0 | 0 | 0 | 0 | 1 | 2 |
| methadone | | benzenes;
diarylmethane;
ketone;
tertiary amino compound | | 1969 | 1971 | 54.2 | low | 1 | 4 | 0 | 0 | 0 | 0 |
| methoxychlor | | organochlorine insecticide | | 1976 | 2020 | 26.0 | low | 0 | 1 | 0 | 0 | 1 | 0 |
| methyl parathion | | C-nitro compound;
organic thiophosphate;
organothiophosphate insecticide | acaricide;
agrochemical;
antifungal agent;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
environmental contaminant;
genotoxin | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| methyl salicylate | | benzoate ester;
methyl ester;
salicylates | flavouring agent;
insect attractant;
metabolite | 2008 | 2009 | 15.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| metolachlor | | aromatic amide;
benzenes;
ether;
organochlorine compound | | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| metoprolol | | aromatic ether;
propanolamine;
secondary alcohol;
secondary amino compound | antihypertensive agent;
beta-adrenergic antagonist;
environmental contaminant;
geroprotector;
xenobiotic | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| metronidazole | | C-nitro compound;
imidazoles;
primary alcohol | antiamoebic agent;
antibacterial drug;
antimicrobial agent;
antiparasitic agent;
antitrichomonal drug;
environmental contaminant;
prodrug;
radiosensitizing agent;
xenobiotic | 1988 | 2019 | 18.2 | low | 0 | 1 | 0 | 2 | 2 | 0 |
| metyrapone | | aromatic ketone | antimetabolite;
diagnostic agent;
EC 1.14.15.4 (steroid 11beta-monooxygenase) inhibitor | 1999 | 2003 | 23.0 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| miconazole | | dichlorobenzene;
ether;
imidazoles | | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| midazolam | | imidazobenzodiazepine;
monofluorobenzenes;
organochlorine compound | anticonvulsant;
antineoplastic agent;
anxiolytic drug;
apoptosis inducer;
central nervous system depressant;
GABAA receptor agonist;
general anaesthetic;
muscle relaxant;
sedative | 2010 | 2018 | 10.0 | low | 1 | 0 | 0 | 1 | 1 | 0 |
| entinostat | | benzamides;
carbamate ester;
primary amino compound;
pyridines;
substituted aniline | antineoplastic agent;
apoptosis inducer;
EC 3.5.1.98 (histone deacetylase) inhibitor | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| ethylmaleimide | | maleimides | anticoronaviral agent;
EC 1.3.1.8 [acyl-CoA dehydrogenase (NADP(+))] inhibitor;
EC 2.1.1.122 [(S)-tetrahydroprotoberberine N-methyltransferase] inhibitor;
EC 2.7.1.1 (hexokinase) inhibitor | 1972 | 2002 | 41.3 | low | 0 | 2 | 0 | 1 | 0 | 0 |
| nabumetone | | methoxynaphthalene;
methyl ketone | cyclooxygenase 2 inhibitor;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
prodrug | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| nalidixic acid | | 1,8-naphthyridine derivative;
monocarboxylic acid;
quinolone antibiotic | antibacterial drug;
antimicrobial agent;
DNA synthesis inhibitor | 1974 | 1974 | 50.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| nifedipine | | C-nitro compound;
dihydropyridine;
methyl ester | calcium channel blocker;
human metabolite;
tocolytic agent;
vasodilator agent | 1993 | 1993 | 31.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| niflumic acid | | aromatic carboxylic acid;
pyridines | | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| nimodipine | | 2-methoxyethyl ester;
C-nitro compound;
dicarboxylic acids and O-substituted derivatives;
diester;
dihydropyridine;
isopropyl ester | antihypertensive agent;
calcium channel blocker;
cardiovascular drug;
vasodilator agent | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| nitroglycerin | | nitroglycerol | explosive;
muscle relaxant;
nitric oxide donor;
prodrug;
tocolytic agent;
vasodilator agent;
xenobiotic | 2007 | 2021 | 10.0 | low | 0 | 0 | 0 | 1 | 0 | 1 |
| nitromide | | | | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| norfloxacin | | fluoroquinolone antibiotic;
N-arylpiperazine;
quinolinemonocarboxylic acid;
quinolone antibiotic;
quinolone | antibacterial drug;
DNA synthesis inhibitor;
environmental contaminant;
xenobiotic | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| ns 1619 | | (trifluoromethyl)benzenes;
benzimidazoles;
phenols | potassium channel opener | 2007 | 2016 | 12.0 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| n-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide | | aromatic ether;
C-nitro compound;
sulfonamide | antineoplastic agent;
cyclooxygenase 2 inhibitor | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| ofloxacin | | 3-oxo monocarboxylic acid;
N-arylpiperazine;
N-methylpiperazine;
organofluorine compound;
oxazinoquinoline | | 1997 | 2019 | 12.2 | low | 0 | 0 | 1 | 0 | 3 | 0 |
| oxolinic acid | | aromatic carboxylic acid;
organic heterotricyclic compound;
oxacycle;
quinolinemonocarboxylic acid;
quinolone antibiotic | antibacterial drug;
antifungal agent;
antiinfective agent;
antimicrobial agent;
enzyme inhibitor | 1987 | 1987 | 37.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| oxybenzone | | hydroxybenzophenone;
monomethoxybenzene | dermatologic drug;
environmental contaminant;
protective agent;
ultraviolet filter;
xenobiotic | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| quinone | | 1,4-benzoquinones | cofactor;
human xenobiotic metabolite;
mouse metabolite | 1962 | 2015 | 29.0 | low | 0 | 2 | 1 | 4 | 1 | 0 |
| papaverine | | benzylisoquinoline alkaloid;
dimethoxybenzene;
isoquinolines | antispasmodic drug;
vasodilator agent | 1967 | 1967 | 57.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| 4-chlorophenol | | monochlorophenol | | 2007 | 2015 | 13.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| 4-dichlorobenzene | | dichlorobenzene | insecticide | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 1,7-dimethylxanthine | | dimethylxanthine | central nervous system stimulant;
human blood serum metabolite;
human xenobiotic metabolite;
mouse metabolite | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| pargyline | | aromatic amine | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| pd 98059 | | aromatic amine;
monomethoxyflavone | EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor;
geroprotector | 2004 | 2008 | 17.2 | low | 0 | 0 | 0 | 4 | 0 | 0 |
| pentobarbital | | barbiturates | GABAA receptor agonist | 1971 | 1971 | 53.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| pentoxifylline | | oxopurine | | 1997 | 1999 | 26.0 | low | 1 | 0 | 2 | 0 | 0 | 0 |
| phenacetin | | acetamides;
aromatic ether | cyclooxygenase 3 inhibitor;
non-narcotic analgesic;
peripheral nervous system drug | 1972 | 2013 | 23.5 | low | 0 | 1 | 2 | 1 | 2 | 0 |
| phenobarbital | | barbiturates | anticonvulsant;
drug allergen;
excitatory amino acid antagonist;
sedative | 1972 | 2013 | 38.9 | low | 0 | 15 | 0 | 0 | 1 | 0 |
| phenoxybenzamine | | aromatic amine | | 1968 | 1968 | 56.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| phenylmethylsulfonyl fluoride | | acyl fluoride | serine proteinase inhibitor | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| moxonidine | | organohalogen compound;
pyrimidines | | 1998 | 1998 | 26.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| pioglitazone | | aromatic ether;
pyridines;
thiazolidinediones | antidepressant;
cardioprotective agent;
EC 2.7.1.33 (pantothenate kinase) inhibitor;
EC 6.2.1.3 (long-chain-fatty-acid--CoA ligase) inhibitor;
ferroptosis inhibitor;
geroprotector;
hypoglycemic agent;
insulin-sensitizing drug;
PPARgamma agonist;
xenobiotic | 2012 | 2014 | 11.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| potassium chloride | | inorganic chloride;
inorganic potassium salt;
potassium salt | fertilizer | 2007 | 2022 | 9.5 | low | 0 | 0 | 0 | 1 | 2 | 1 |
| 4-aminobenzoic acid | | aminobenzoate;
aromatic amino-acid anion | Escherichia coli metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| ag 1879 | | aromatic amine;
monochlorobenzenes;
pyrazolopyrimidine | beta-adrenergic antagonist;
EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor;
geroprotector | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| primaquine | | aminoquinoline;
aromatic ether;
N-substituted diamine | antimalarial | 1972 | 2003 | 31.7 | low | 3 | 2 | 9 | 1 | 0 | 0 |
| proadifen | | diarylmethane | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| probenecid | | benzoic acids;
sulfonamide | uricosuric drug | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| probucol | | dithioketal;
polyphenol | anti-inflammatory drug;
anticholesteremic drug;
antilipemic drug;
antioxidant;
cardiovascular drug | 1995 | 2005 | 22.7 | low | 0 | 0 | 1 | 2 | 0 | 0 |
| procainamide | | benzamides | anti-arrhythmia drug;
platelet aggregation inhibitor;
sodium channel blocker | 1971 | 1973 | 52.0 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| propidium | | phenanthridines;
quaternary ammonium ion | fluorochrome;
intercalator | 1999 | 2013 | 18.0 | low | 0 | 0 | 1 | 0 | 1 | 0 |
| propofol | | phenols | anticonvulsant;
antiemetic;
intravenous anaesthetic;
radical scavenger;
sedative | 2010 | 2013 | 12.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| propranolol | | naphthalenes;
propanolamine;
secondary amine | anti-arrhythmia drug;
antihypertensive agent;
anxiolytic drug;
beta-adrenergic antagonist;
environmental contaminant;
human blood serum metabolite;
vasodilator agent;
xenobiotic | 1968 | 2000 | 41.0 | low | 0 | 4 | 2 | 0 | 0 | 0 |
| propyl gallate | | trihydroxybenzoic acid | | 1992 | 2010 | 23.0 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| protopine | | dibenzazecine alkaloid | plant metabolite | 2003 | 2020 | 10.0 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| pyrimethamine | | aminopyrimidine;
monochlorobenzenes | antimalarial;
antiprotozoal drug;
EC 1.5.1.3 (dihydrofolate reductase) inhibitor | 1972 | 2012 | 30.6 | low | 4 | 6 | 18 | 5 | 1 | 0 |
| 1,6-bis(cyclohexyloximinocarbonyl)hexane | | carbamate ester;
organonitrogen compound | | 1993 | 1997 | 28.7 | low | 0 | 0 | 3 | 0 | 0 | 0 |
| ro 31-8220 | | imidothiocarbamic ester;
indoles;
maleimides | EC 2.7.11.13 (protein kinase C) inhibitor | 1993 | 1993 | 31.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| rofecoxib | | butenolide;
sulfone | analgesic;
cyclooxygenase 2 inhibitor;
non-steroidal anti-inflammatory drug | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| rolipram | | pyrrolidin-2-ones | antidepressant;
EC 3.1.4.* (phosphoric diester hydrolase) inhibitor | 2003 | 2016 | 14.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| s-methylisothiopseudouronium | | | | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| sanguinarine | | alkaloid antibiotic;
benzophenanthridine alkaloid;
botanical anti-fungal agent | | 1989 | 1989 | 35.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| sb 202190 | | imidazoles;
organofluorine compound;
phenols;
pyridines | apoptosis inducer;
EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| sulfadiazine | | pyrimidines;
substituted aniline;
sulfonamide antibiotic;
sulfonamide | antiinfective agent;
antimicrobial agent;
antiprotozoal drug;
coccidiostat;
drug allergen;
EC 1.1.1.153 [sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)] inhibitor;
EC 2.5.1.15 (dihydropteroate synthase) inhibitor;
environmental contaminant;
xenobiotic | 1972 | 1976 | 50.3 | low | 0 | 3 | 0 | 0 | 0 | 0 |
| spiperone | | aromatic ketone;
azaspiro compound;
organofluorine compound;
piperidines;
tertiary amino compound | alpha-adrenergic antagonist;
antipsychotic agent;
dopaminergic antagonist;
psychotropic drug;
serotonergic antagonist | 1984 | 1988 | 38.0 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| stearic acid | | long-chain fatty acid;
saturated fatty acid;
straight-chain saturated fatty acid | algal metabolite;
Daphnia magna metabolite;
human metabolite;
plant metabolite | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| vorinostat | | dicarboxylic acid diamide;
hydroxamic acid | antineoplastic agent;
apoptosis inducer;
EC 3.5.1.98 (histone deacetylase) inhibitor | 2014 | 2018 | 8.3 | low | 0 | 0 | 0 | 0 | 3 | 0 |
| sulfadimethoxine | | aromatic ether;
pyrimidines;
substituted aniline;
sulfonamide antibiotic;
sulfonamide | antiinfective agent;
antimicrobial agent;
drug allergen;
environmental contaminant;
xenobiotic | 1976 | 1976 | 48.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| sulfamethazine | | pyrimidines;
sulfonamide antibiotic;
sulfonamide | antibacterial drug;
antiinfective agent;
antimicrobial agent;
carcinogenic agent;
drug allergen;
EC 2.5.1.15 (dihydropteroate synthase) inhibitor;
environmental contaminant;
ligand;
xenobiotic | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| sulfamethoxazole | | isoxazoles;
substituted aniline;
sulfonamide antibiotic;
sulfonamide | antibacterial agent;
antiinfective agent;
antimicrobial agent;
drug allergen;
EC 1.1.1.153 [sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)] inhibitor;
EC 2.5.1.15 (dihydropteroate synthase) inhibitor;
environmental contaminant;
epitope;
P450 inhibitor;
xenobiotic | 2016 | 2018 | 7.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| sulfanilamide | | substituted aniline;
sulfonamide antibiotic;
sulfonamide | antibacterial agent;
drug allergen;
EC 4.2.1.1 (carbonic anhydrase) inhibitor | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| sulfasalazine | | | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| sulfisomidine | | pyrimidines;
sulfonamide antibiotic;
sulfonamide | antiinfective agent | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| sulfisoxazole | | isoxazoles;
sulfonamide antibiotic;
sulfonamide | antibacterial drug;
drug allergen | 1973 | 1973 | 51.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| sulforaphane | | isothiocyanate;
sulfoxide | antineoplastic agent;
antioxidant;
EC 3.5.1.98 (histone deacetylase) inhibitor;
plant metabolite | 2014 | 2021 | 6.5 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| talipexole | | azepine | | 1986 | 1993 | 34.0 | low | 0 | 1 | 2 | 0 | 0 | 0 |
| temozolomide | | imidazotetrazine;
monocarboxylic acid amide;
triazene derivative | alkylating agent;
antineoplastic agent;
prodrug | 2014 | 2017 | 8.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| terfenadine | | diarylmethane | | 2002 | 2021 | 12.5 | low | 0 | 0 | 0 | 1 | 0 | 1 |
| tetraethylammonium | | quaternary ammonium ion | | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| thalidomide | | phthalimides;
piperidones | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 2,4-thiazolidinedione | | thiazolidenedione | | 2003 | 2021 | 12.0 | low | 0 | 0 | 0 | 1 | 0 | 1 |
| ticlopidine | | monochlorobenzenes;
thienopyridine | anticoagulant;
fibrin modulating drug;
hematologic agent;
P2Y12 receptor antagonist;
platelet aggregation inhibitor | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| tinidazole | | imidazoles | antiamoebic agent;
antibacterial drug;
antiparasitic agent;
antiprotozoal drug | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| tolbutamide | | N-sulfonylurea | human metabolite;
hypoglycemic agent;
insulin secretagogue;
potassium channel blocker | 2000 | 2013 | 16.3 | low | 0 | 0 | 1 | 1 | 1 | 0 |
| triclosan | | aromatic ether;
dichlorobenzene;
monochlorobenzenes;
phenols | antibacterial agent;
antimalarial;
drug allergen;
EC 1.3.1.9 [enoyl-[acyl-carrier-protein] reductase (NADH)] inhibitor;
EC 1.5.1.3 (dihydrofolate reductase) inhibitor;
fungicide;
persistent organic pollutant;
xenobiotic | 2013 | 2017 | 9.7 | low | 0 | 0 | 0 | 0 | 3 | 0 |
| trifluoperazine | | N-alkylpiperazine;
N-methylpiperazine;
organofluorine compound;
phenothiazines | antiemetic;
calmodulin antagonist;
dopaminergic antagonist;
EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor;
EC 5.3.3.5 (cholestenol Delta-isomerase) inhibitor;
phenothiazine antipsychotic drug | 1972 | 2001 | 37.5 | low | 0 | 1 | 0 | 1 | 0 | 0 |
| trihexyphenidyl | | amine | | 1971 | 1971 | 53.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| trimethoprim | | aminopyrimidine;
methoxybenzenes | antibacterial drug;
diuretic;
drug allergen;
EC 1.5.1.3 (dihydrofolate reductase) inhibitor;
environmental contaminant;
xenobiotic | 1974 | 1976 | 49.0 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| tyramine | | monoamine molecular messenger;
primary amino compound;
tyramines | EC 3.1.1.8 (cholinesterase) inhibitor;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
neurotransmitter | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| urethane | | carbamate ester | fungal metabolite;
mutagen | 1963 | 1974 | 54.3 | low | 0 | 3 | 0 | 0 | 0 | 0 |
| w 7 | | | | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| pirinixic acid | | aryl sulfide;
organochlorine compound;
pyrimidines | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| hydrocortisone acetate | | cortisol ester;
tertiary alpha-hydroxy ketone | | 1982 | 1982 | 42.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| mitomycin | | mitomycin | alkylating agent;
antineoplastic agent | 1995 | 1995 | 29.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| corticosterone | | 11beta-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
C21-steroid;
glucocorticoid;
primary alpha-hydroxy ketone | human metabolite;
mouse metabolite | 2006 | 2019 | 12.3 | low | 0 | 0 | 0 | 2 | 1 | 0 |
| prednisolone | | 11beta-hydroxy steroid;
17alpha-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(1),Delta(4)-steroid;
C21-steroid;
glucocorticoid;
primary alpha-hydroxy ketone;
tertiary alpha-hydroxy ketone | adrenergic agent;
anti-inflammatory drug;
antineoplastic agent;
drug metabolite;
environmental contaminant;
immunosuppressive agent;
xenobiotic | 1981 | 2001 | 31.8 | low | 1 | 2 | 2 | 1 | 0 | 0 |
| estriol | | 16alpha-hydroxy steroid;
17beta-hydroxy steroid;
3-hydroxy steroid | estrogen;
human metabolite;
human xenobiotic metabolite;
mouse metabolite | 1974 | 1974 | 50.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| reserpine | | alkaloid ester;
methyl ester;
yohimban alkaloid | adrenergic uptake inhibitor;
antihypertensive agent;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
environmental contaminant;
first generation antipsychotic;
plant metabolite;
xenobiotic | 1986 | 1986 | 38.0 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| sorbitol | | glucitol | cathartic;
Escherichia coli metabolite;
food humectant;
human metabolite;
laxative;
metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite;
sweetening agent | 1973 | 2007 | 29.3 | low | 0 | 1 | 0 | 2 | 0 | 0 |
| alloxan | | pyrimidone | hyperglycemic agent;
metabolite | 1957 | 1957 | 67.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| thymidine | | pyrimidine 2'-deoxyribonucleoside | Escherichia coli metabolite;
human metabolite;
metabolite;
mouse metabolite | 1970 | 2010 | 37.3 | low | 0 | 4 | 1 | 1 | 0 | 0 |
| piperonyl butoxide | | benzodioxoles | pesticide synergist | 2002 | 2020 | 15.2 | low | 0 | 0 | 0 | 3 | 1 | 0 |
| bromouracil | | nucleobase analogue;
pyrimidines | mutagen | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| hydroxyproline | | 4-hydroxyproline;
L-alpha-amino acid zwitterion | human metabolite;
mouse metabolite;
plant metabolite | 1994 | 2015 | 20.0 | low | 0 | 0 | 1 | 1 | 1 | 0 |
| thyroxine | | 2-halophenol;
iodophenol;
L-phenylalanine derivative;
non-proteinogenic L-alpha-amino acid;
thyroxine zwitterion;
thyroxine | antithyroid drug;
human metabolite;
mouse metabolite;
thyroid hormone | 1972 | 2023 | 18.3 | low | 1 | 1 | 0 | 0 | 0 | 2 |
| carbachol | | ammonium salt;
carbamate ester | cardiotonic drug;
miotic;
muscarinic agonist;
nicotinic acetylcholine receptor agonist;
non-narcotic analgesic | 1996 | 2019 | 20.0 | low | 0 | 0 | 2 | 0 | 1 | 0 |
| spironolactone | | 3-oxo-Delta(4) steroid;
oxaspiro compound;
steroid lactone;
thioester | aldosterone antagonist;
antihypertensive agent;
diuretic;
environmental contaminant;
xenobiotic | 1964 | 2006 | 39.0 | low | 0 | 1 | 0 | 1 | 0 | 0 |
| aldosterone | | 11beta-hydroxy steroid;
18-oxo steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
C21-steroid hormone;
mineralocorticoid;
primary alpha-hydroxy ketone;
steroid aldehyde | human metabolite;
mouse metabolite | 2009 | 2017 | 11.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| prednisone | | 11-oxo steroid;
17alpha-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(1),Delta(4)-steroid;
C21-steroid;
glucocorticoid;
primary alpha-hydroxy ketone;
tertiary alpha-hydroxy ketone | adrenergic agent;
anti-inflammatory drug;
antineoplastic agent;
immunosuppressive agent;
prodrug | 1966 | 2019 | 24.7 | low | 4 | 3 | 0 | 1 | 5 | 0 |
| estrone | | 17-oxo steroid;
3-hydroxy steroid;
phenolic steroid;
phenols | antineoplastic agent;
bone density conservation agent;
estrogen;
human metabolite;
mouse metabolite | 1962 | 1974 | 55.6 | low | 0 | 5 | 0 | 0 | 0 | 0 |
| dehydroepiandrosterone | | 17-oxo steroid;
3beta-hydroxy-Delta(5)-steroid;
androstanoid | androgen;
human metabolite;
mouse metabolite | 1988 | 1988 | 36.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| 1,2,5,6-dibenzanthracene | | ortho-fused polycyclic arene | mutagen | 1988 | 2006 | 26.8 | low | 0 | 2 | 0 | 3 | 0 | 0 |
| dichlororibofuranosylbenzimidazole | | | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| hydroxyacetylaminofluorene | | 2-acetamidofluorenes | | 1977 | 1996 | 38.3 | low | 0 | 2 | 1 | 0 | 0 | 0 |
| 2-acetylaminofluorene | | 2-acetamidofluorenes | antimitotic;
carcinogenic agent;
epitope;
mutagen | 1953 | 1997 | 38.7 | low | 0 | 6 | 6 | 0 | 0 | 0 |
| adrenochrome | | indoles | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| penicillin g | | penicillin allergen;
penicillin | antibacterial drug;
drug allergen;
epitope | 1974 | 1974 | 50.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| pilocarpine | | pilocarpine | antiglaucoma drug | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| pentylenetetrazole | | organic heterobicyclic compound;
organonitrogen heterocyclic compound | | 1974 | 2007 | 33.5 | low | 0 | 1 | 0 | 1 | 0 | 0 |
| triiodothyronine | | 2-halophenol;
amino acid zwitterion;
iodophenol;
iodothyronine | human metabolite;
mouse metabolite;
thyroid hormone | 2022 | 2023 | 1.5 | low | 1 | 0 | 0 | 0 | 0 | 2 |
| isoflurophate | | dialkyl phosphate | | 1968 | 1968 | 56.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| biguanides | | guanidines | | 1947 | 1988 | 59.2 | low | 0 | 4 | 0 | 0 | 0 | 0 |
| carbon tetrachloride | | chlorocarbon;
chloromethanes | hepatotoxic agent;
refrigerant | 1968 | 2020 | 20.6 | low | 0 | 2 | 0 | 3 | 5 | 0 |
| cantharidin | | cyclic dicarboxylic anhydride;
monoterpenoid | EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor;
herbicide | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| alanine | | alanine zwitterion;
alanine;
L-alpha-amino acid;
proteinogenic amino acid;
pyruvate family amino acid | EC 4.3.1.15 (diaminopropionate ammonia-lyase) inhibitor;
fundamental metabolite | 2004 | 2021 | 11.8 | low | 0 | 0 | 0 | 2 | 2 | 1 |
| serine | | L-alpha-amino acid;
proteinogenic amino acid;
serine family amino acid;
serine zwitterion;
serine | algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| desoxycorticosterone acetate | | corticosteroid hormone | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| benz(a)anthracene | | ortho-fused polycyclic arene;
tetraphenes | | 1953 | 2019 | 39.6 | low | 0 | 24 | 2 | 5 | 6 | 0 |
| 4-nitroquinoline-1-oxide | | C-nitro compound;
quinoline N-oxide | carcinogenic agent | 1977 | 1995 | 38.0 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| chloramphenicol | | C-nitro compound;
carboxamide;
diol;
organochlorine compound | antibacterial drug;
antimicrobial agent;
Escherichia coli metabolite;
geroprotector;
Mycoplasma genitalium metabolite;
protein synthesis inhibitor | 1966 | 2018 | 45.0 | low | 0 | 6 | 1 | 0 | 1 | 0 |
| aspartic acid | | aspartate family amino acid;
aspartic acid;
L-alpha-amino acid;
proteinogenic amino acid | Escherichia coli metabolite;
mouse metabolite;
neurotransmitter | 2005 | 2012 | 15.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| glutamine | | amino acid zwitterion;
glutamine family amino acid;
glutamine;
L-alpha-amino acid;
polar amino acid zwitterion;
proteinogenic amino acid | EC 1.14.13.39 (nitric oxide synthase) inhibitor;
Escherichia coli metabolite;
human metabolite;
metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite | 1974 | 2022 | 22.7 | low | 0 | 1 | 0 | 1 | 0 | 1 |
| lysine | | aspartate family amino acid;
L-alpha-amino acid zwitterion;
L-alpha-amino acid;
lysine;
organic molecular entity;
proteinogenic amino acid | algal metabolite;
anticonvulsant;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite | 1989 | 2014 | 20.8 | low | 0 | 1 | 1 | 1 | 2 | 0 |
| cyanides | | pseudohalide anion | EC 1.9.3.1 (cytochrome c oxidase) inhibitor | 1970 | 2017 | 35.0 | low | 0 | 3 | 0 | 1 | 1 | 0 |
| physostigmine | | carbamate ester;
indole alkaloid | antidote to curare poisoning;
EC 3.1.1.8 (cholinesterase) inhibitor;
miotic | 1968 | 1970 | 55.0 | low | 0 | 3 | 0 | 0 | 0 | 0 |
| sucrose | | glycosyl glycoside | algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
osmolyte;
Saccharomyces cerevisiae metabolite;
sweetening agent | 1969 | 2006 | 31.0 | low | 0 | 1 | 0 | 2 | 0 | 0 |
| sucrose | | glycosyl glycoside | algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
osmolyte;
Saccharomyces cerevisiae metabolite;
sweetening agent | 1969 | 2018 | 22.3 | low | 0 | 1 | 0 | 5 | 1 | 0 |
| ethinyl estradiol | | 17-hydroxy steroid;
3-hydroxy steroid;
terminal acetylenic compound | xenoestrogen | 2004 | 2017 | 14.7 | low | 0 | 0 | 0 | 3 | 3 | 0 |
| tubocurarine | | bisbenzylisoquinoline alkaloid | drug allergen;
muscle relaxant;
nicotinic antagonist | 1998 | 1998 | 26.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| 9,10-dimethyl-1,2-benzanthracene | | ortho-fused polycyclic arene;
tetraphenes | carcinogenic agent | 1976 | 2008 | 36.9 | low | 0 | 12 | 3 | 3 | 0 | 0 |
| apomorphine | | aporphine alkaloid | alpha-adrenergic drug;
antidyskinesia agent;
antiparkinson drug;
dopamine agonist;
emetic;
serotonergic drug | 1975 | 1991 | 41.2 | low | 0 | 3 | 1 | 0 | 0 | 0 |
| aminopyrine | | pyrazolone;
tertiary amino compound | antipyretic;
environmental contaminant;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
xenobiotic | 1972 | 1972 | 52.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| methyltestosterone | | 17beta-hydroxy steroid;
3-oxo-Delta(4) steroid;
enone | anabolic agent;
androgen;
antineoplastic agent | 1972 | 1976 | 50.0 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| tetrabenazine | | benzoquinolizine;
cyclic ketone;
tertiary amino compound | | 1966 | 1966 | 58.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| puromycin aminonucleoside | | 3'-deoxyribonucleoside;
adenosines | | 2008 | 2019 | 8.7 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| adenosine diphosphate | | adenosine 5'-phosphate;
purine ribonucleoside 5'-diphosphate | fundamental metabolite;
human metabolite | 1972 | 2021 | 40.9 | low | 0 | 19 | 1 | 3 | 2 | 1 |
| 2,3,4,6-tetrachlorophenol | | tetrachlorophenol | xenobiotic metabolite | 2007 | 2017 | 10.2 | low | 0 | 0 | 0 | 1 | 3 | 0 |
| uridine | | uridines | drug metabolite;
fundamental metabolite;
human metabolite | 1973 | 2011 | 28.8 | low | 0 | 2 | 0 | 1 | 1 | 0 |
| uridine diphosphate | | pyrimidine ribonucleoside 5'-diphosphate;
uridine 5'-phosphate | Escherichia coli metabolite;
mouse metabolite | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| kanamycin a | | kanamycins | bacterial metabolite | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| bromodeoxyuridine | | pyrimidine 2'-deoxyribonucleoside | antimetabolite;
antineoplastic agent | 1996 | 2011 | 17.6 | low | 0 | 0 | 1 | 3 | 1 | 0 |
| galactose | | D-galactose;
galactopyranose | Escherichia coli metabolite;
mouse metabolite | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| carbostyril | | monohydroxyquinoline;
quinolone | bacterial xenobiotic metabolite | 2000 | 2019 | 12.8 | low | 0 | 0 | 1 | 0 | 3 | 0 |
| phenylephrine | | phenols;
phenylethanolamines;
secondary amino compound | alpha-adrenergic agonist;
cardiotonic drug;
mydriatic agent;
nasal decongestant;
protective agent;
sympathomimetic agent;
vasoconstrictor agent | 2002 | 2010 | 17.7 | low | 0 | 0 | 0 | 3 | 0 | 0 |
| edetic acid | | ethylenediamine derivative;
polyamino carboxylic acid;
tetracarboxylic acid | anticoagulant;
antidote;
chelator;
copper chelator;
geroprotector | 1979 | 2016 | 22.2 | low | 0 | 1 | 1 | 2 | 2 | 0 |
| p-dimethylaminoazobenzene | | azobenzenes | | 1970 | 1979 | 49.5 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| tyrosine | | amino acid zwitterion;
erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid;
proteinogenic amino acid;
tyrosine | EC 1.3.1.43 (arogenate dehydrogenase) inhibitor;
fundamental metabolite;
micronutrient;
nutraceutical | 1993 | 2022 | 18.1 | low | 0 | 0 | 2 | 5 | 1 | 1 |
| adenosine monophosphate | | adenosine 5'-phosphate;
purine ribonucleoside 5'-monophosphate | adenosine A1 receptor agonist;
cofactor;
EC 3.1.3.1 (alkaline phosphatase) inhibitor;
EC 3.1.3.11 (fructose-bisphosphatase) inhibitor;
fundamental metabolite;
micronutrient;
nutraceutical | 1972 | 2021 | 35.6 | low | 0 | 4 | 0 | 2 | 0 | 1 |
| methicillin | | penicillin allergen;
penicillin | antibacterial drug | 1974 | 2016 | 29.0 | low | 0 | 1 | 0 | 0 | 1 | 0 |
| methylene blue | | organic chloride salt | acid-base indicator;
antidepressant;
antimalarial;
antimicrobial agent;
antioxidant;
cardioprotective agent;
EC 1.4.3.4 (monoamine oxidase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
EC 4.6.1.2 (guanylate cyclase) inhibitor;
fluorochrome;
histological dye;
neuroprotective agent;
physical tracer | 1975 | 2022 | 20.0 | low | 0 | 1 | 0 | 0 | 1 | 1 |
| zoxazolamine | | benzoxazole | | 1966 | 1971 | 55.5 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| leucine | | amino acid zwitterion;
L-alpha-amino acid;
leucine;
proteinogenic amino acid;
pyruvate family amino acid | algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite | 1966 | 2008 | 39.4 | low | 0 | 9 | 1 | 4 | 0 | 0 |
| aniline | | anilines;
primary arylamine | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 2-aminoisobutyric acid | | 2,2-dialkylglycine zwitterion;
2,2-dialkylglycine | | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| dimethylnitrosamine | | nitrosamine | geroprotector;
mutagen | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| androstenedione | | 17-oxo steroid;
3-oxo-Delta(4) steroid;
androstanoid | androgen;
Daphnia magna metabolite;
human metabolite;
mouse metabolite | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| methionine | | aspartate family amino acid;
L-alpha-amino acid;
methionine zwitterion;
methionine;
proteinogenic amino acid | antidote to paracetamol poisoning;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical | 1969 | 2014 | 40.8 | low | 0 | 5 | 1 | 1 | 1 | 0 |
| 1,2-dipalmitoylphosphatidylcholine | | | | 1997 | 2014 | 19.1 | low | 0 | 0 | 2 | 3 | 2 | 0 |
| phenylalanine | | amino acid zwitterion;
erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid;
phenylalanine;
proteinogenic amino acid | algal metabolite;
EC 3.1.3.1 (alkaline phosphatase) inhibitor;
Escherichia coli metabolite;
human xenobiotic metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite | 1970 | 2020 | 24.6 | low | 0 | 4 | 1 | 2 | 5 | 0 |
| colchicine | | alkaloid;
colchicine | anti-inflammatory agent;
gout suppressant;
mutagen | 1968 | 1972 | 54.0 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| cytidine | | cytidines | Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite | 1973 | 1973 | 51.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| 1-naphthaldehyde | | naphthaldehyde | mouse metabolite | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| cycloheximide | | antibiotic fungicide;
cyclic ketone;
dicarboximide;
piperidine antibiotic;
piperidones;
secondary alcohol | anticoronaviral agent;
bacterial metabolite;
ferroptosis inhibitor;
neuroprotective agent;
protein synthesis inhibitor | 1974 | 2018 | 28.0 | low | 0 | 2 | 5 | 2 | 1 | 0 |
| 2-naphthaldehyde | | naphthaldehyde | mouse metabolite | 1965 | 1965 | 59.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| egtazic acid | | diether;
tertiary amino compound;
tetracarboxylic acid | chelator | 1993 | 2011 | 19.5 | low | 0 | 0 | 1 | 2 | 1 | 0 |
| chloroform | | chloromethanes;
one-carbon compound | carcinogenic agent;
central nervous system drug;
inhalation anaesthetic;
non-polar solvent;
refrigerant | 1968 | 2022 | 29.7 | low | 0 | 2 | 2 | 2 | 0 | 1 |
| sodium citrate, anhydrous | | organic sodium salt | anticoagulant;
flavouring agent | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| dimethylformamide | | formamides;
volatile organic compound | geroprotector;
hepatotoxic agent;
polar aprotic solvent | 1970 | 2022 | 28.0 | low | 0 | 1 | 0 | 0 | 0 | 1 |
| norethindrone | | 17beta-hydroxy steroid;
3-oxo-Delta(4) steroid;
terminal acetylenic compound;
tertiary alcohol | progestin;
synthetic oral contraceptive | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| triaziquone | | 1,4-benzoquinones;
aziridines | alkylating agent;
antineoplastic agent | 1969 | 1969 | 55.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| 17-alpha-hydroxyprogesterone | | 17alpha-hydroxy-C21-steroid;
17alpha-hydroxy steroid;
tertiary alpha-hydroxy ketone | human metabolite;
metabolite;
mouse metabolite;
progestin | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| ampicillin | | beta-lactam antibiotic;
penicillin allergen;
penicillin | antibacterial drug | 1974 | 1974 | 50.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| mannitol | | mannitol | allergen;
antiglaucoma drug;
compatible osmolytes;
Escherichia coli metabolite;
food anticaking agent;
food bulking agent;
food humectant;
food stabiliser;
food thickening agent;
hapten;
metabolite;
osmotic diuretic;
sweetening agent | 2008 | 2018 | 11.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| cytarabine | | beta-D-arabinoside;
monosaccharide derivative;
pyrimidine nucleoside | antimetabolite;
antineoplastic agent;
antiviral agent;
immunosuppressive agent | 2008 | 2016 | 12.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| dithionitrobenzoic acid | | nitrobenzoic acid;
organic disulfide | indicator | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| trifluridine | | nucleoside analogue;
organofluorine compound;
pyrimidine 2'-deoxyribonucleoside | antimetabolite;
antineoplastic agent;
antiviral drug;
EC 2.1.1.45 (thymidylate synthase) inhibitor | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| ornithine | | non-proteinogenic L-alpha-amino acid;
ornithine | algal metabolite;
hepatoprotective agent;
mouse metabolite | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| dinitrofluorobenzene | | C-nitro compound;
organofluorine compound | agrochemical;
allergen;
chromatographic reagent;
EC 2.7.3.2 (creatine kinase) inhibitor;
protein-sequencing agent;
spectrophotometric reagent | 2001 | 2012 | 17.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| asparagine | | amino acid zwitterion;
asparagine;
aspartate family amino acid;
L-alpha-amino acid;
proteinogenic amino acid | Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| histidine | | amino acid zwitterion;
histidine;
L-alpha-amino acid;
polar amino acid zwitterion;
proteinogenic amino acid | algal metabolite;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite | 1970 | 1972 | 52.7 | low | 0 | 3 | 0 | 0 | 0 | 0 |
| n-pentanol | | pentanol;
short-chain primary fatty alcohol | human metabolite;
plant metabolite | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 1,1,1-trichloroethane | | chloroethanes | polar solvent | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| valine | | L-alpha-amino acid zwitterion;
L-alpha-amino acid;
proteinogenic amino acid;
pyruvate family amino acid;
valine | algal metabolite;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite | 1969 | 2010 | 28.3 | low | 0 | 1 | 0 | 2 | 0 | 0 |
| threonine | | amino acid zwitterion;
aspartate family amino acid;
L-alpha-amino acid;
proteinogenic amino acid;
threonine | algal metabolite;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| dichlorodiphenyldichloroethane | | chlorophenylethane;
monochlorobenzenes;
organochlorine insecticide | xenobiotic metabolite | 2000 | 2006 | 21.0 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| tryptophan | | erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid zwitterion;
L-alpha-amino acid;
proteinogenic amino acid;
tryptophan zwitterion;
tryptophan | antidepressant;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite | 2001 | 2022 | 13.1 | low | 0 | 0 | 0 | 4 | 2 | 1 |
| arginine | | arginine;
glutamine family amino acid;
L-alpha-amino acid;
proteinogenic amino acid | biomarker;
Escherichia coli metabolite;
micronutrient;
mouse metabolite;
nutraceutical | 1966 | 2016 | 40.4 | low | 0 | 11 | 3 | 0 | 2 | 0 |
| ethylene | | alkene;
gas molecular entity | plant hormone;
refrigerant | 2007 | 2020 | 11.7 | low | 0 | 0 | 0 | 2 | 1 | 0 |
| acetylene | | alkyne;
gas molecular entity;
terminal acetylenic compound | | 1992 | 2010 | 21.1 | low | 0 | 0 | 2 | 5 | 0 | 0 |
| boranes | | boranes;
mononuclear parent hydride | | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| acetonitrile | | aliphatic nitrile;
volatile organic compound | EC 3.5.1.4 (amidase) inhibitor;
NMR chemical shift reference compound;
polar aprotic solvent | 1990 | 2012 | 20.6 | low | 0 | 0 | 2 | 4 | 1 | 0 |
| methylene chloride | | chloromethanes;
volatile organic compound | carcinogenic agent;
polar aprotic solvent;
refrigerant | 2002 | 2022 | 13.0 | low | 0 | 0 | 0 | 2 | 1 | 1 |
| carbon disulfide | | one-carbon compound;
organosulfur compound | | 1968 | 1968 | 56.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| boron trifluoride | | boron fluoride | NMR chemical shift reference compound | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| vinylidene chloride | | chloroethenes | carcinogenic agent;
mouse metabolite;
mutagen | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| trichloroacetic acid | | monocarboxylic acid;
organochlorine compound | carcinogenic agent;
metabolite;
mouse metabolite | 1967 | 2017 | 37.3 | low | 0 | 2 | 0 | 0 | 1 | 0 |
| trifluoroacetic acid | | fluoroalkanoic acid | human xenobiotic metabolite;
NMR chemical shift reference compound;
reagent | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| pinacol | | glycol | | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| fluoxymesterone | | 11beta-hydroxy steroid;
17beta-hydroxy steroid;
3-oxo-Delta(4) steroid;
anabolic androgenic steroid;
fluorinated steroid | anabolic agent;
antineoplastic agent | 1968 | 1968 | 56.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| phencyclidine | | benzenes;
piperidines | anaesthetic;
neurotoxin;
NMDA receptor antagonist;
psychotropic drug | 1964 | 2022 | 24.1 | low | 0 | 2 | 2 | 3 | 3 | 1 |
| tromethamine | | primary amino compound;
triol | buffer | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| quinic acid | | | | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| isoprene | | alkadiene;
hemiterpene;
volatile organic compound | plant metabolite | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| trichloroethylene | | chloroethenes | inhalation anaesthetic;
mouse metabolite | 2016 | 2019 | 6.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| acrylic acid | | alpha,beta-unsaturated monocarboxylic acid | metabolite | 1998 | 1998 | 26.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| tetrabromobisphenol a | | brominated flame retardant;
bromobisphenol | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| bisphenol a | | bisphenol | endocrine disruptor;
environmental contaminant;
xenobiotic;
xenoestrogen | 2000 | 2020 | 10.9 | low | 0 | 0 | 1 | 1 | 8 | 0 |
| benzanthrone | | phenanthrenes | | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| acenaphthene | | acenaphthenes | | 1993 | 2022 | 16.2 | high | 0 | 0 | 5 | 3 | 8 | 1 |
| rotenone | | organic heteropentacyclic compound;
rotenones | antineoplastic agent;
metabolite;
mitochondrial NADH:ubiquinone reductase inhibitor;
phytogenic insecticide;
piscicide;
toxin | 1968 | 2006 | 42.6 | low | 0 | 5 | 0 | 2 | 0 | 0 |
| 9,10-phenanthrenequinone | | phenanthrenes | | 1977 | 2022 | 17.3 | high | 0 | 8 | 21 | 37 | 46 | 6 |
| phanquinone | | orthoquinones | | 1958 | 1958 | 66.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| 9,10-anthraquinone | | anthraquinone | | 2007 | 2019 | 11.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| benzo(f)quinoline | | | | 1988 | 2001 | 31.3 | medium | 0 | 2 | 0 | 1 | 0 | 0 |
| 1-hydroxy-2-naphthoic acid | | hydroxy monocarboxylic acid;
naphthoic acid;
naphthols | bacterial xenobiotic metabolite;
fungal xenobiotic metabolite | 1965 | 2020 | 14.9 | high | 0 | 1 | 1 | 5 | 9 | 0 |
| 1-naphthoic acid | | naphthoic acid | bacterial xenobiotic metabolite;
fungal xenobiotic metabolite | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 1-nitronaphthalene | | mononitronaphthalene | environmental contaminant;
mouse metabolite | 1985 | 1992 | 35.5 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| fluorene | | ortho-fused polycyclic arene;
ortho-fused tricyclic hydrocarbon | | 1953 | 2023 | 15.1 | medium | 0 | 4 | 10 | 25 | 38 | 7 |
| carbazole | | carbazole | | 2009 | 2018 | 10.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| 1,2,3-trichlorobenzene | | trichlorobenzene | | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 2,4,6-trichlorophenol | | trichlorophenol | carcinogenic agent | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| n-vinyl-2-pyrrolidinone | | pyrrolidin-2-ones | | 2007 | 2016 | 11.5 | low | 0 | 0 | 0 | 1 | 3 | 0 |
| 2-nitrotoluene | | mononitrotoluene | carcinogenic agent;
environmental contaminant | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 1-methylnaphthalene | | methylnaphthalene | carcinogenic agent;
plant metabolite | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 1-chloronaphthalene | | | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 1-naphthol | | naphthol | genotoxin;
human xenobiotic metabolite | 1965 | 2016 | 16.8 | low | 0 | 1 | 1 | 2 | 8 | 0 |
| 2-phenylphenol | | hydroxybiphenyls | antifungal agrochemical;
environmental food contaminant | 2005 | 2010 | 16.0 | low | 0 | 0 | 0 | 3 | 0 | 0 |
| anthrone | | anthracenone | radical scavenger | 2016 | 2019 | 6.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| quinoxalines | | mancude organic heterobicyclic parent;
naphthyridine;
ortho-fused heteroarene | | 1972 | 2016 | 29.4 | low | 0 | 2 | 0 | 2 | 1 | 0 |
| quinoline | | azaarene;
mancude organic heterobicyclic parent;
ortho-fused heteroarene;
quinolines | | 1999 | 2011 | 18.0 | low | 0 | 0 | 1 | 2 | 1 | 0 |
| 2-methylnaphthalene | | methylnaphthalene | | 1962 | 1962 | 62.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| 2-chloronaphthalene | | | | 2003 | 2003 | 21.0 | medium | 0 | 0 | 0 | 1 | 0 | 0 |
| 2-naphthylamine | | naphthylamine | carcinogenic agent | 1979 | 1985 | 42.0 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| naphthacene | | acene;
tetracenes | | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| diphenyl | | aromatic fungicide;
benzenes;
biphenyls | antifungal agrochemical;
antimicrobial food preservative | 1953 | 2021 | 19.7 | low | 0 | 2 | 4 | 7 | 9 | 1 |
| 3-hydroxy-2-naphthoic acid | | naphthoic acid | | 1965 | 1965 | 59.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| xanthenes | | xanthene | | 1968 | 2020 | 22.8 | low | 0 | 1 | 1 | 3 | 1 | 0 |
| phenothiazine | | phenothiazine | ferroptosis inhibitor;
plant metabolite;
radical scavenger | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| benzidine | | biphenyls;
substituted aniline | carcinogenic agent | 1985 | 1985 | 39.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| propylparaben | | benzoate ester;
paraben;
phenols | antifungal agent;
antimicrobial agent | 1999 | 2003 | 23.0 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| benzoyl peroxide | | carbonyl compound | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 2-xylene | | xylene | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 2-dichlorobenzene | | dichlorobenzene | hepatotoxic agent;
metabolite | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 1,2,4,5-tetrachlorobenzene | | tetrachlorobenzene | | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| styrene oxide | | epoxide | human xenobiotic metabolite | 1987 | 2000 | 30.5 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| 4-butyrolactone | | butan-4-olide | metabolite;
neurotoxin | 1986 | 1994 | 34.2 | low | 0 | 2 | 2 | 0 | 0 | 0 |
| ethyl lactate | | ethyl ester;
lactate ester;
secondary alcohol | metabolite | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| ethylene dimethacrylate | | enoate ester | allergen;
cross-linking reagent;
polymerisation monomer | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| nitrobenzene | | nitroarene;
nitrobenzenes | | 2013 | 2014 | 10.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| 3-nitrotoluene | | mononitrotoluene | | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| trehalose | | trehalose | Escherichia coli metabolite;
geroprotector;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite | 2004 | 2020 | 11.7 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| sym-trinitrobenzene | | trinitrobenzene | explosive | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| carvone | | botanical anti-fungal agent;
carvones | allergen | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 3-dinitrobenzene | | dinitrobenzene | neurotoxin | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 4-bromophenacyl bromide | | | | 1988 | 1998 | 30.5 | low | 0 | 1 | 3 | 0 | 0 | 0 |
| 4-cymene | | monoterpene;
toluenes | human urinary metabolite;
plant metabolite;
volatile oil component | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 4-nitrotoluene | | mononitrotoluene | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 4-nitroanisole | | 4-nitroanisoles | | 1996 | 1996 | 28.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| styrene | | styrenes;
vinylarene;
volatile organic compound | mouse metabolite;
mutagen;
plant metabolite | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| benzylamine | | aralkylamine;
primary amine | allergen;
EC 3.5.5.1 (nitrilase) inhibitor;
plant metabolite | 2011 | 2017 | 10.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| benzonitrile | | benzenes;
nitrile | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| diphenylmethane | | diarylmethane | | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| phenyl ether | | aromatic ether | plant metabolite | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| boric acid | | boric acids | astringent | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| 1,2-dihydrostilbene | | diphenylethane | | 1983 | 1983 | 41.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| 3-phenylpropanal | | aldehyde;
benzenes | flavouring agent;
plant metabolite | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| caprolactam | | caprolactams | human blood serum metabolite | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 4-phenylenediamine | | phenylenediamine | allergen;
dye;
hapten;
reagent | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| 4-vinyl-1-cyclohexene dioxide | | epoxide | carcinogenic agent | 2013 | 2017 | 9.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| epichlorohydrin | | epoxide;
organochlorine compound | | 1989 | 1989 | 35.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| glycidyl methacrylate | | enoate ester;
epoxide | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 1,3-butadiene | | butadiene | carcinogenic agent;
mutagen | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| allyl chloride | | organochlorine compound | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| propargyl alcohol | | propynol;
terminal acetylenic compound;
volatile organic compound | antifungal agent;
Saccharomyces cerevisiae metabolite | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| glyoxal | | dialdehyde | agrochemical;
allergen;
pesticide;
plant growth regulator | 1962 | 1962 | 62.0 | low | 0 | 4 | 0 | 0 | 0 | 0 |
| 2-methylpentane | | alkane | | 2005 | 2016 | 15.0 | low | 0 | 0 | 0 | 5 | 3 | 0 |
| 3-hydroxybutanal | | | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| vinyl acetate | | acetate ester | | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| maleic anhydride | | cyclic dicarboxylic anhydride;
furans | allergen | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 3-phenylenediamine | | phenylenediamine | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| mesitylene | | trimethylbenzene | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 1,3,5-trichlorobenzene | | trichlorobenzene | | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| melamine | | triamino-1,3,5-triazine | xenobiotic metabolite | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| chlorobenzene | | monochlorobenzenes | solvent | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| pyrroles | | pyrrole;
secondary amine | | 1968 | 2013 | 28.3 | low | 0 | 3 | 1 | 4 | 2 | 0 |
| furan | | furans;
mancude organic heteromonocyclic parent;
monocyclic heteroarene | carcinogenic agent;
hepatotoxic agent;
Maillard reaction product | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| thiophenes | | mancude organic heteromonocyclic parent;
monocyclic heteroarene;
thiophenes;
volatile organic compound | non-polar solvent | 1990 | 2020 | 16.4 | low | 0 | 0 | 3 | 6 | 10 | 0 |
| isopropyl myristate | | fatty acid ester | | 2005 | 2007 | 18.0 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| n-hexane | | alkane;
volatile organic compound | neurotoxin;
non-polar solvent | 2009 | 2016 | 11.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| 2-ethoxyethanol | | glycol ether;
primary alcohol | protic solvent;
teratogenic agent | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| cyclohexane | | cycloalkane;
volatile organic compound | non-polar solvent | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| cyclohexene | | cycloalkene | | 2001 | 2012 | 17.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| dodecyltrimethylammonium | | quaternary ammonium ion | | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| n-decyl alcohol | | decanol;
primary alcohol | metabolite;
pheromone;
protic solvent | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| n-dodecane | | alkane | plant metabolite | 2005 | 2018 | 12.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| eicosane | | long-chain alkane | plant metabolite | 2004 | 2020 | 14.0 | low | 0 | 0 | 0 | 2 | 1 | 0 |
| dimethyl ether | | ether | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| triphenyl phosphate | | aryl phosphate | flame retardant;
plasticiser | 1983 | 1983 | 41.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| diethylhexyl phthalate | | diester;
phthalate ester | androstane receptor agonist;
apoptosis inhibitor;
plasticiser | 1995 | 2010 | 21.5 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| hexachlorobenzene | | aromatic fungicide;
chlorobenzenes | antifungal agrochemical;
carcinogenic agent;
persistent organic pollutant | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| trinitrotoluene | | trinitrotoluene | explosive | 1964 | 1964 | 60.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| framycetin | | aminoglycoside | allergen;
antibacterial drug;
Escherichia coli metabolite | 1974 | 2017 | 27.3 | low | 0 | 1 | 1 | 0 | 1 | 0 |
| tetralin | | ortho-fused bicyclic hydrocarbon;
tetralins | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| isoquinoline | | azaarene;
isoquinolines;
mancude organic heterobicyclic parent;
ortho-fused heteroarene | | 2006 | 2013 | 14.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| anthracene | | acene;
anthracenes;
ortho-fused tricyclic hydrocarbon | | 1946 | 2023 | 18.1 | medium | 0 | 12 | 20 | 45 | 52 | 3 |
| 2,4-dichlorophenol | | dichlorophenol | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 2,4-dinitrotoluene | | dinitrotoluene | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 1,4-naphthoquinone | | 1,4-naphthoquinones | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 1-naphthylamine | | naphthylamine | human xenobiotic metabolite | 1985 | 2013 | 24.7 | low | 0 | 1 | 1 | 0 | 1 | 0 |
| 2-naphthol | | naphthol | antinematodal drug;
genotoxin;
human urinary metabolite;
human xenobiotic metabolite;
mouse metabolite;
radical scavenger | 1955 | 2023 | 16.4 | low | 0 | 4 | 5 | 16 | 24 | 2 |
| 2-naphthol | | naphthol | antinematodal drug;
genotoxin;
human urinary metabolite;
human xenobiotic metabolite;
mouse metabolite;
radical scavenger | 1955 | 2020 | 17.0 | low | 0 | 4 | 5 | 16 | 24 | 0 |
| 2-aminothiophenol | | aryl thiol;
substituted aniline | plant metabolite | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| protocatechualdehyde | | dihydroxybenzaldehyde | | 1985 | 2016 | 23.3 | low | 0 | 4 | 2 | 7 | 2 | 0 |
| dodecyl sulfate | | alkyl sulfate | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| sterogenol | | bromide salt;
pyridinium salt | antiseptic drug;
EC 2.7.11.18 (myosin-light-chain kinase) inhibitor;
surfactant | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| citronellol | | monoterpenoid | plant metabolite | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| ethyl acetate | | acetate ester;
ethyl ester;
volatile organic compound | EC 3.4.19.3 (pyroglutamyl-peptidase I) inhibitor;
metabolite;
polar aprotic solvent;
Saccharomyces cerevisiae metabolite | 1986 | 2009 | 25.0 | low | 0 | 1 | 2 | 2 | 0 | 0 |
| hexanoic acid | | medium-chain fatty acid;
straight-chain saturated fatty acid | human metabolite;
plant metabolite | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| n-heptane | | alkane;
volatile organic compound | non-polar solvent;
plant metabolite | 2006 | 2011 | 15.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| sodium cyanide | | cyanide salt;
one-carbon compound;
sodium salt | EC 1.15.1.1 (superoxide dismutase) inhibitor | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| pregnenolone | | 20-oxo steroid;
3beta-hydroxy-Delta(5)-steroid;
C21-steroid | human metabolite;
mouse metabolite | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| diphenhydramine hydrochloride | | hydrochloride;
organoammonium salt | anti-allergic agent;
antiemetic;
antiparkinson drug;
antipruritic drug;
H1-receptor antagonist;
local anaesthetic;
muscarinic antagonist;
sedative | 1955 | 1969 | 62.0 | low | 0 | 4 | 0 | 0 | 0 | 0 |
| ditiocarb | | dithiocarbamic acids | chelator;
copper chelator | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 1,2-dihydroxybenzene-3,5-disulfonic acid disodium salt | | organic molecular entity | | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| aziridine | | azacycloalkane;
aziridines;
saturated organic heteromonocyclic parent | alkylating agent | 2008 | 2010 | 15.0 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| sulfalene | | pyrazines;
sulfonamide antibiotic;
sulfonamide | | 1976 | 1995 | 38.5 | low | 1 | 1 | 1 | 0 | 0 | 0 |
| cycloguanil | | triazines | antifolate;
antiinfective agent;
antimalarial;
antiparasitic agent;
antiprotozoal drug;
EC 1.5.1.3 (dihydrofolate reductase) inhibitor | 1994 | 1996 | 29.3 | low | 0 | 0 | 3 | 0 | 0 | 0 |
| catechin | | catechin | antioxidant;
plant metabolite | 1995 | 2022 | 10.0 | low | 0 | 0 | 1 | 1 | 6 | 1 |
| homoarginine | | homoarginine;
L-lysine derivative;
non-proteinogenic L-alpha-amino acid | biomarker;
EC 3.1.3.1 (alkaline phosphatase) inhibitor;
human metabolite;
rat metabolite;
xenobiotic metabolite | 1991 | 1991 | 33.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| coronene | | ortho- and peri-fused polycyclic arene | | 1988 | 2019 | 17.6 | low | 0 | 1 | 1 | 0 | 3 | 0 |
| 1,12-benzoperylene | | ortho- and peri-fused polycyclic arene | | 2001 | 2009 | 18.3 | medium | 0 | 0 | 0 | 3 | 0 | 0 |
| anthanthrene | | ortho- and peri-fused polycyclic arene | | 2012 | 2012 | 12.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 |
| dibenzo(a,l)pyrene | | ortho- and peri-fused polycyclic arene | human metabolite;
mutagen | 1998 | 1998 | 26.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| benzo(e)pyrene | | ortho- and peri-fused polycyclic arene | carcinogenic agent;
mutagen | 1984 | 2014 | 27.0 | low | 0 | 2 | 1 | 1 | 1 | 0 |
| indeno(1,2,3-cd)pyrene | | pyrenes | | 2012 | 2016 | 10.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| benzo(c)phenanthrene | | benzenoid aromatic compound;
ortho-fused polycyclic arene | | 1958 | 2017 | 29.3 | high | 0 | 13 | 13 | 17 | 1 | 0 |
| benzo(g)chrysene | | | | 1998 | 2001 | 24.5 | high | 0 | 0 | 1 | 1 | 0 | 0 |
| perylene | | ortho- and peri-fused polycyclic arene;
perylenes | | 1979 | 2022 | 25.7 | low | 1 | 5 | 2 | 6 | 1 | 1 |
| benzo(j)fluoranthene | | naphthalenes | | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| benzo(b)fluoranthene | | ortho- and peri-fused polycyclic arene | mutagen | 2001 | 2022 | 8.4 | medium | 0 | 0 | 0 | 2 | 6 | 2 |
| fluoranthene | | ortho- and peri-fused polycyclic arene | | 1981 | 2023 | 14.0 | high | 0 | 2 | 15 | 52 | 57 | 10 |
| benzo(k)fluoranthene | | naphthalenes | | 2001 | 2023 | 16.5 | low | 0 | 0 | 0 | 3 | 0 | 1 |
| acenaphthylene | | acenaphthylenes;
ortho- and peri-fused polycyclic arene;
ortho- and peri-fused tricyclic hydrocarbon | | 1994 | 2023 | 13.4 | medium | 0 | 0 | 3 | 2 | 1 | 3 |
| picene | | ortho-fused polycyclic arene | | 1988 | 1988 | 36.0 | medium | 0 | 1 | 0 | 0 | 0 | 0 |
| benzotriphenylene | | carbopolycyclic compound | | 1974 | 1995 | 38.3 | medium | 0 | 2 | 1 | 0 | 0 | 0 |
| dibenzacridine | | | | 1987 | 1987 | 37.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| triphenylene | | ortho-fused polycyclic arene | | 1980 | 2010 | 33.1 | medium | 0 | 5 | 0 | 2 | 0 | 0 |
| chrysene | | ortho-fused polycyclic arene | plant metabolite | 1949 | 2023 | 25.9 | high | 0 | 24 | 2 | 16 | 12 | 3 |
| benzo(c)cinnoline | | | | 1945 | 2015 | 26.3 | high | 0 | 1 | 2 | 2 | 2 | 0 |
| benzo(h)quinoline | | | | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| benzo(b)naphtho(2,1-d)thiophene | | organic heterotricyclic compound;
organosulfur heterocyclic compound | | 1990 | 1990 | 34.0 | medium | 0 | 0 | 1 | 0 | 0 | 0 |
| cinnoline | | azaarene;
cinnolines;
mancude organic heterobicyclic parent;
ortho-fused heteroarene | | 1945 | 2011 | 35.0 | low | 0 | 1 | 0 | 0 | 2 | 0 |
| quinazolines | | azaarene;
mancude organic heterobicyclic parent;
ortho-fused heteroarene;
quinazolines | | 1945 | 2016 | 31.6 | low | 1 | 4 | 1 | 3 | 2 | 0 |
| acridines | | acridines;
mancude organic heterotricyclic parent;
polycyclic heteroarene | genotoxin | 1953 | 2018 | 41.6 | low | 0 | 15 | 3 | 3 | 3 | 0 |
| dibenzo(1,4)dioxin | | dibenzodioxine;
heteranthrene;
mancude organic heterotricyclic parent;
oxacycle;
polycyclic heteroarene | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| phenoxathiin | | | | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| indazoles | | indazole | | 2011 | 2017 | 10.0 | low | 0 | 0 | 0 | 0 | 3 | 0 |
| azulene | | azulenes;
mancude carbobicyclic parent;
ortho-fused bicyclic arene | plant metabolite;
volatile oil component | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| adamantane | | adamantanes;
polycyclic alkane | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| cyclopentane | | cycloalkane;
cyclopentanes;
volatile organic compound | non-polar solvent | 1955 | 2020 | 33.3 | low | 0 | 12 | 0 | 3 | 7 | 0 |
| isoxazoles | | isoxazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene | | 1976 | 2015 | 20.8 | low | 0 | 1 | 0 | 3 | 2 | 0 |
| oxazoles | | 1,3-oxazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene | | 1970 | 2021 | 28.8 | low | 0 | 2 | 0 | 0 | 1 | 1 |
| thiazoles | | 1,3-thiazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene | | 2002 | 2020 | 15.7 | low | 0 | 0 | 0 | 9 | 3 | 0 |
| pyrimidine | | diazine;
pyrimidines | Daphnia magna metabolite | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| pyrazines | | diazine;
pyrazines | Daphnia magna metabolite | 1974 | 2013 | 21.8 | low | 0 | 1 | 1 | 2 | 2 | 0 |
| hydrazine | | azane;
hydrazines | EC 4.3.1.10 (serine-sulfate ammonia-lyase) inhibitor | 1967 | 2004 | 42.7 | low | 0 | 2 | 0 | 1 | 0 | 0 |
| thiocyanate | | pseudohalide anion;
sulfur molecular entity | human metabolite | 1990 | 1990 | 34.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| evans blue | | organic sodium salt | fluorochrome;
histological dye;
sodium channel blocker;
teratogenic agent | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| monocrotaline | | pyrrolizidine alkaloid | | 2000 | 2014 | 17.8 | low | 0 | 0 | 1 | 2 | 1 | 0 |
| azacitidine | | N-glycosyl-1,3,5-triazine;
nucleoside analogue | antineoplastic agent | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| perfluorooctanoic acid | | fluoroalkanoic acid | carcinogenic agent;
endocrine disruptor;
environmental contaminant;
surfactant;
xenobiotic | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| citrulline | | amino acid zwitterion;
citrulline | Daphnia magna metabolite;
EC 1.14.13.39 (nitric oxide synthase) inhibitor;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
protective agent;
Saccharomyces cerevisiae metabolite | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| perfluorobutyric acid | | fluoroalkanoic acid | chromatographic reagent;
environmental contaminant;
xenobiotic | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| silicon carbide | | organosilicon compound | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| lithocholic acid | | bile acid;
C24-steroid;
monohydroxy-5beta-cholanic acid | geroprotector;
human metabolite;
mouse metabolite | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| nandrolone | | 17beta-hydroxy steroid;
3-oxo-Delta(4) steroid;
anabolic androgenic steroid | human metabolite | 1968 | 2009 | 41.3 | low | 0 | 2 | 0 | 1 | 0 | 0 |
| hydantoins | | imidazolidine-2,4-dione | | 1978 | 2004 | 33.0 | low | 0 | 1 | 0 | 1 | 0 | 0 |
| fluorobenzenes | | monofluorobenzenes | NMR chemical shift reference compound | 1975 | 2011 | 22.5 | low | 0 | 1 | 0 | 1 | 2 | 0 |
| homocystine | | amino acid zwitterion;
homocystines | human metabolite | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| propadiene | | allenes | | 2008 | 2009 | 15.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| dextropropoxyphene | | 1-benzyl-3-(dimethylamino)-2-methyl-1-phenylpropyl propanoate | mu-opioid receptor agonist;
opioid analgesic | 1971 | 1971 | 53.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| methylguanidine | | guanidines | EC 1.14.13.39 (nitric oxide synthase) inhibitor;
metabolite;
uremic toxin | 1979 | 1979 | 45.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| limestone | | calcium salt;
carbonate salt;
inorganic calcium salt;
one-carbon compound | antacid;
fertilizer;
food colouring;
food firming agent | 1994 | 2023 | 17.0 | low | 0 | 0 | 1 | 1 | 0 | 1 |
| hopane | | terpenoid fundamental parent;
triterpene | | 2005 | 2014 | 14.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| pinane | | carbobicyclic compound;
monoterpene;
terpenoid fundamental parent | plant metabolite | 1989 | 1989 | 35.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| chenodeoxycholic acid | | bile acid;
C24-steroid;
dihydroxy-5beta-cholanic acid | human metabolite;
mouse metabolite | 1980 | 1980 | 44.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| isocorydine | | aporphine alkaloid | | 1996 | 1996 | 28.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| nuciferine | | | | 1978 | 1978 | 46.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| fusarium | | | | 1972 | 2014 | 26.0 | low | 0 | 1 | 0 | 2 | 1 | 0 |
| boldine | | aporphine alkaloid | | 1997 | 2005 | 22.0 | low | 0 | 0 | 1 | 2 | 0 | 0 |
| rhein | | dihydroxyanthraquinone | | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| plumbagin | | hydroxy-1,4-naphthoquinone;
phenols | anticoagulant;
antineoplastic agent;
immunological adjuvant;
metabolite | 2006 | 2022 | 10.0 | low | 0 | 0 | 0 | 1 | 0 | 1 |
| diphenic acid | | dicarboxylic acid | | 1992 | 2014 | 18.4 | medium | 0 | 0 | 2 | 0 | 3 | 0 |
| phosphoadenosine phosphosulfate | | acyl sulfate;
adenosine bisphosphate;
purine ribonucleoside bisphosphate | Escherichia coli metabolite;
mouse metabolite | 1986 | 1988 | 37.0 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| emetine | | isoquinoline alkaloid;
pyridoisoquinoline | antiamoebic agent;
anticoronaviral agent;
antiinfective agent;
antimalarial;
antineoplastic agent;
antiprotozoal drug;
antiviral agent;
autophagy inhibitor;
emetic;
expectorant;
plant metabolite;
protein synthesis inhibitor | 1977 | 2003 | 35.0 | low | 0 | 2 | 0 | 1 | 0 | 0 |
| retene | | | | 1946 | 2022 | 15.1 | high | 1 | 2 | 0 | 20 | 22 | 4 |
| 9-phenanthrol | | phenanthrol | TRPM4 channel inhibitor | 1965 | 2023 | 10.1 | high | 0 | 1 | 2 | 6 | 42 | 7 |
| lophine | | | | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| 9-fluorenone | | fluoren-9-ones | fungal xenobiotic metabolite | 1988 | 2023 | 17.2 | low | 0 | 1 | 1 | 0 | 2 | 1 |
| flavanone | | flavanones | | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| kainic acid | | dicarboxylic acid;
L-proline derivative;
non-proteinogenic L-alpha-amino acid;
pyrrolidinecarboxylic acid | antinematodal drug;
excitatory amino acid agonist | 1998 | 2018 | 14.2 | low | 0 | 0 | 1 | 0 | 4 | 0 |
| indoline | | indoles | | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| dithiol | | | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| sodium carbonate | | carbonate salt;
organic sodium salt | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| phloretic acid | | hydroxy monocarboxylic acid | plant metabolite | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| alpha-aminopyridine | | | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| cyanogen bromide | | | | 1996 | 1996 | 28.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| oleanolic acid | | hydroxy monocarboxylic acid;
pentacyclic triterpenoid | plant metabolite | 1991 | 2015 | 18.2 | low | 0 | 0 | 1 | 2 | 2 | 0 |
| methadyl acetate | | diarylmethane | | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| abietic acid | | abietane diterpenoid;
monocarboxylic acid | plant metabolite | 1980 | 2016 | 26.9 | high | 0 | 14 | 34 | 34 | 1 | 0 |
| hematoxylin | | organic heterotetracyclic compound;
oxacycle;
polyphenol;
tertiary alcohol | histological dye;
plant metabolite | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| podophyllotoxin | | furonaphthodioxole;
lignan;
organic heterotetracyclic compound | antimitotic;
antineoplastic agent;
keratolytic drug;
microtubule-destabilising agent;
plant metabolite;
tubulin modulator | 2010 | 2014 | 12.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| dihydrotestosterone | | 17beta-hydroxy steroid;
17beta-hydroxyandrostan-3-one;
3-oxo-5alpha-steroid | androgen;
Daphnia magna metabolite;
human metabolite;
mouse metabolite | 1974 | 2012 | 26.0 | low | 0 | 1 | 0 | 1 | 1 | 0 |
| physcione | | dihydroxyanthraquinone | anti-inflammatory agent;
antibacterial agent;
antifungal agent;
antineoplastic agent;
apoptosis inducer;
hepatoprotective agent;
metabolite | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 1,2-naphthoquinone | | 1,2-naphthoquinones | aryl hydrocarbon receptor agonist;
carcinogenic agent | 1999 | 2017 | 13.4 | low | 0 | 0 | 1 | 1 | 3 | 0 |
| flavone | | flavones | metabolite;
nematicide | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 2,3,4,5,6-pentachloroaniline | | | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| azomycin | | C-nitro compound;
imidazoles | antitubercular agent | 1994 | 1994 | 30.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| tropolone | | alpha-hydroxy ketone;
cyclic ketone;
enol | bacterial metabolite;
fungicide;
toxin | 1953 | 2015 | 40.0 | low | 0 | 1 | 0 | 0 | 1 | 0 |
| phenylacetylene | | benzenes | | 2001 | 2009 | 19.0 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| tricaprylin | | octanoate ester;
triglyceride | anticonvulsant;
plant metabolite | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| tropone | | | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 3-aminobutyric acid | | amino acid zwitterion;
beta-amino acid;
monocarboxylic acid | metabolite | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| malondialdehyde | | dialdehyde | biomarker | 1991 | 2023 | 12.5 | low | 0 | 0 | 2 | 17 | 20 | 5 |
| n-hexadecane | | long-chain alkane | non-polar solvent;
plant metabolite;
volatile oil component | 1990 | 2022 | 15.5 | low | 0 | 0 | 2 | 11 | 8 | 1 |
| magnesium carbonate | | carbonate salt;
magnesium salt;
one-carbon compound;
organic magnesium salt | antacid;
fertilizer | 1998 | 1998 | 26.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| trinitrobenzenesulfonic acid | | arenesulfonic acid;
C-nitro compound | epitope;
explosive;
reagent | 2008 | 2015 | 12.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| eosine yellowish-(ys) | | organic sodium salt;
organobromine compound | fluorochrome;
histological dye | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| paeonol | | methoxybenzenes;
phenols | metabolite | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| neutral red | | hydrochloride | acid-base indicator;
dye;
two-colour indicator | 1996 | 2014 | 16.7 | low | 0 | 0 | 1 | 0 | 2 | 0 |
| glycerylphosphorylcholine | | glycerophosphocholine | | 1991 | 1991 | 33.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| 1,4-dimethylnaphthalene | | dimethylnaphthalene | | 1981 | 1981 | 43.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| 1,2-dihydroxynaphthalene | | naphthalenediol | mouse metabolite | 1965 | 1965 | 59.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| 3-hydroxyflavone | | flavonols;
monohydroxyflavone | | 1991 | 2020 | 20.3 | low | 0 | 0 | 2 | 0 | 1 | 0 |
| 2,6-dimethylnaphthalene | | dimethylnaphthalene | environmental contaminant | 1986 | 1986 | 38.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| allyl sulfide | | organic sulfide | | 1993 | 1993 | 31.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| octadecane | | long-chain alkane | bacterial metabolite;
plant metabolite | 2001 | 2017 | 12.8 | low | 0 | 0 | 0 | 2 | 4 | 0 |
| 9-nitroanthracene | | anthracenes | | 1982 | 1982 | 42.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| pentafluorobenzoic acid | | perfluorinated compound | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| triphenylphosphine | | benzenes;
tertiary phosphine | NMR chemical shift reference compound;
reducing agent | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| 1,1'-binaphthyl | | | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| alpha-naphthoflavone | | extended flavonoid;
naphtho-gamma-pyrone;
organic heterotricyclic compound | aryl hydrocarbon receptor agonist;
aryl hydrocarbon receptor antagonist;
EC 1.14.14.14 (aromatase) inhibitor | 1985 | 2016 | 21.9 | low | 0 | 1 | 2 | 3 | 1 | 0 |
| dansyl chloride | | aminonaphthalene;
sulfonic acid derivative | | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| 2,6-dinitrotoluene | | dinitrotoluene | genotoxin | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 2-nitrofluorene | | nitroarene | carcinogenic agent;
mutagen | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| pentachlorobenzene | | pentachlorobenzenes | persistent organic pollutant | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 1-methylanthracene | | | | 2002 | 2002 | 22.0 | medium | 0 | 0 | 0 | 1 | 0 | 0 |
| 2-methylanthracene | | | | 2021 | 2021 | 3.0 | medium | 0 | 0 | 0 | 0 | 0 | 1 |
| 2-anthramine | | anthracenamine | | 1976 | 2009 | 34.2 | low | 0 | 3 | 0 | 1 | 0 | 0 |
| acetylcysteine | | acetylcysteine;
L-cysteine derivative;
N-acetyl-L-amino acid | antidote to paracetamol poisoning;
antiinfective agent;
antioxidant;
antiviral drug;
ferroptosis inhibitor;
geroprotector;
human metabolite;
mucolytic;
radical scavenger;
vulnerary | 1962 | 2018 | 19.6 | low | 1 | 2 | 0 | 5 | 7 | 0 |
| diazoacetic ester | | | | 1946 | 1946 | 78.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| 1,3-dicyanobenzene | | nitrile | | 2019 | 2019 | 5.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 |
| 3,5-dichloroaniline | | dichloroaniline | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| n-tetradecane | | long-chain alkane | plant metabolite;
volatile oil component | 2012 | 2014 | 10.8 | low | 0 | 0 | 0 | 0 | 4 | 0 |
| phytane | | diterpene | | 2010 | 2016 | 11.3 | medium | 0 | 0 | 0 | 1 | 2 | 0 |
| glycochenodeoxycholic acid | | bile acid glycine conjugate | human metabolite | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| erythromycin | | cyclic ketone;
erythromycin | | 1974 | 2011 | 25.4 | low | 0 | 1 | 0 | 3 | 1 | 0 |
| tetracosane | | long-chain alkane | plant metabolite;
volatile oil component | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| nitrosoguanidines | | | | 1972 | 1974 | 51.0 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| methylnitrosourea | | N-nitrosoureas | alkylating agent;
carcinogenic agent;
mutagen;
teratogenic agent | 1982 | 1982 | 42.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| acetylenedicarboxylic acid dimethyl ester | | | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 2,3-dimethylmaleic anhydride | | butenolide | | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| chloracizine | | | | 1993 | 1994 | 30.5 | medium | 0 | 0 | 2 | 0 | 0 | 0 |
| 4-nitrophenyl acetate | | C-nitro compound;
phenyl acetates | | 1984 | 1984 | 40.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| 1-methylphenanthrene | | phenanthrenes | mutagen | 1983 | 2017 | 17.1 | high | 0 | 1 | 2 | 2 | 5 | 0 |
| n-hydroxy-4-acetylaminostilbene | | | | 1996 | 1996 | 28.0 | medium | 0 | 0 | 1 | 0 | 0 | 0 |
| 3-nitrofluoranthene | | nitronaphthalene | | 1999 | 2023 | 13.0 | low | 0 | 0 | 1 | 0 | 0 | 1 |
| hexafluoroisopropanol | | organofluorine compound;
secondary alcohol | drug metabolite | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 9-aminophenanthrene | | phenanthrenamine | | 1984 | 2006 | 26.5 | high | 0 | 1 | 1 | 2 | 0 | 0 |
| deoxycytidine | | pyrimidine 2'-deoxyribonucleoside | Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite | 2012 | 2018 | 8.7 | low | 0 | 0 | 0 | 0 | 3 | 0 |
| 2'-deoxyadenosine | | purine 2'-deoxyribonucleoside;
purines 2'-deoxy-D-ribonucleoside | Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| testolactone | | 3-oxo-Delta(1),Delta(4)-steroid;
seco-androstane | | 1963 | 1971 | 55.0 | low | 2 | 9 | 0 | 0 | 0 | 0 |
| undecane | | alkane | | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 3-vinylpyridine | | | | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| tetramethylpyrazine | | alkaloid;
pyrazines | antineoplastic agent;
apoptosis inhibitor;
bacterial metabolite;
neuroprotective agent;
platelet aggregation inhibitor;
vasodilator agent | 1999 | 2007 | 21.0 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| decabromobiphenyl ether | | polybromodiphenyl ether | neurotoxin | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| calcium peroxide | | calcium oxides | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| durapatite | | | | 1984 | 1993 | 35.5 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| sodium hydroxide | | alkali metal hydroxide | | 2005 | 2023 | 12.7 | low | 0 | 0 | 0 | 2 | 0 | 1 |
| zinc oxide | | zinc molecular entity | | 1990 | 2022 | 19.6 | low | 0 | 0 | 4 | 1 | 2 | 1 |
| arsenic trioxide | | | | 2009 | 2022 | 8.9 | low | 0 | 0 | 0 | 2 | 4 | 1 |
| hydrofluoric acid | | hydrogen halide;
mononuclear parent hydride | NMR chemical shift reference compound | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| glycyrrhizic acid | | enone;
glucosiduronic acid;
pentacyclic triterpenoid;
tricarboxylic acid;
triterpenoid saponin | EC 3.4.21.5 (thrombin) inhibitor;
plant metabolite | 2007 | 2014 | 14.2 | low | 0 | 0 | 0 | 3 | 2 | 0 |
| d-alpha tocopherol | | alpha-tocopherol | algal metabolite;
antiatherogenic agent;
anticoagulant;
antioxidant;
antiviral agent;
EC 2.7.11.13 (protein kinase C) inhibitor;
immunomodulator;
micronutrient;
nutraceutical;
plant metabolite | 1966 | 2021 | 24.0 | low | 0 | 1 | 3 | 3 | 1 | 1 |
| tocopherols | | | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| methyl tert-butyl ether | | ether | fuel additive;
metabolite;
non-polar solvent | 1997 | 1997 | 27.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| 6-methylchrysene | | carbopolycyclic compound | | 1985 | 1987 | 37.7 | high | 0 | 3 | 0 | 0 | 0 | 0 |
| stearylamine | | primary aliphatic amine | film-forming compound | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| paraquat | | organic cation | geroprotector;
herbicide | 1974 | 2018 | 29.7 | low | 0 | 1 | 1 | 0 | 1 | 0 |
| pristane | | long-chain alkane;
norterpene | biomarker;
immunological adjuvant | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| tetrabutylammonium | | quaternary ammonium ion | | 2006 | 2017 | 12.3 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| 6h-dibenzo-(b,d)-pyran-6-one | | benzochromenone | plant metabolite | 1992 | 2017 | 15.3 | high | 0 | 0 | 1 | 1 | 4 | 0 |
| amiloride | | aromatic amine;
guanidines;
organochlorine compound;
pyrazines | diuretic;
sodium channel blocker | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 5,6-chrysenequinone | | | | 2009 | 2009 | 15.0 | medium | 0 | 0 | 0 | 1 | 0 | 0 |
| 3-chlorobiphenyl | | monochlorobiphenyl | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 4-chlorobiphenyl | | monochlorobiphenyl | | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| fluorenone oxime | | | | 1986 | 1986 | 38.0 | medium | 0 | 1 | 0 | 0 | 0 | 0 |
| 1-methoxynaphthalene | | | | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| glaucine | | aporphine alkaloid;
organic heterotetracyclic compound;
polyether;
tertiary amino compound | antibacterial agent;
antineoplastic agent;
antitussive;
muscle relaxant;
NF-kappaB inhibitor;
plant metabolite;
platelet aggregation inhibitor;
rat metabolite | 1995 | 1995 | 29.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| fluorescein | | 2-benzofurans;
gamma-lactone;
organic heteropentacyclic compound;
oxaspiro compound;
polyphenol;
xanthene dye | fluorescent dye;
radioopaque medium | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| sulfadoxine | | pyrimidines;
sulfonamide | antibacterial drug;
antimalarial | 1991 | 2012 | 25.7 | low | 3 | 0 | 12 | 3 | 1 | 0 |
| 2-methylphenanthrene | | | | 1962 | 2008 | 29.3 | high | 0 | 1 | 3 | 2 | 0 | 0 |
| uridine diphosphate glucuronic acid | | UDP-D-glucuronic acid | Escherichia coli metabolite;
human metabolite;
mouse metabolite | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 6-chrysenamine | | carbopolycyclic compound | | 1984 | 1989 | 37.4 | high | 0 | 8 | 0 | 0 | 0 | 0 |
| n-octadecyl mercaptan | | | | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| trichloroepoxypropane | | | | 1988 | 1988 | 36.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| fluorescein-5-isothiocyanate | | fluorescein isothiocyanate | | 2005 | 2013 | 15.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| sabinene | | thujene | plant metabolite | 2000 | 2002 | 23.0 | low | 1 | 0 | 1 | 1 | 0 | 0 |
| mannose | | D-aldohexose;
D-mannose;
mannopyranose | metabolite | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| dithiothreitol | | 1,4-dimercaptobutane-2,3-diol;
butanediols;
dithiol;
glycol;
thiol | chelator;
human metabolite;
reducing agent | 1973 | 2021 | 27.8 | low | 0 | 2 | 1 | 1 | 0 | 1 |
| palmatine | | berberine alkaloid;
organic heterotetracyclic compound | plant metabolite | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| cyclazocine | | | | 1967 | 1970 | 55.4 | low | 1 | 5 | 0 | 0 | 0 | 0 |
| 5-methylchrysene | | carbopolycyclic compound | | 1978 | 1990 | 40.4 | high | 0 | 20 | 1 | 0 | 0 | 0 |
| 5,6-dimethylchrysene | | | | 1984 | 1993 | 35.0 | high | 0 | 1 | 2 | 0 | 0 | 0 |
| streptomycin | | antibiotic antifungal drug;
antibiotic fungicide;
streptomycins | antibacterial drug;
antifungal agrochemical;
antimicrobial agent;
antimicrobial drug;
bacterial metabolite;
protein synthesis inhibitor | 1974 | 2004 | 31.0 | low | 0 | 1 | 0 | 2 | 0 | 0 |
| carbonates | | carbon oxoanion | | 1994 | 2012 | 18.5 | low | 0 | 0 | 1 | 2 | 1 | 0 |
| 2-acetamidophenanthrene | | | | 1957 | 1997 | 39.8 | high | 0 | 6 | 3 | 0 | 0 | 0 |
| cladribine | | organochlorine compound;
purine 2'-deoxyribonucleoside | antineoplastic agent;
immunosuppressive agent | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| n-hydroxy-4-acetylaminobiphenyl | | hydroxamic acid | | 1984 | 1984 | 40.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| 1,3-dithiolane | | dithiolane | | 2010 | 2010 | 14.0 | medium | 0 | 0 | 0 | 1 | 0 | 0 |
| dehydroemetine | | aromatic ether;
isoquinolines;
pyridoisoquinoline | antileishmanial agent;
antimalarial;
antiprotozoal drug | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| buthionine sulfoximine | | diastereoisomeric mixture;
homocysteines;
non-proteinogenic alpha-amino acid;
sulfoximide | EC 6.3.2.2 (glutamate--cysteine ligase) inhibitor;
ferroptosis inducer | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 1-hydroxypyrene | | pyrenes | | 1994 | 2020 | 15.4 | low | 0 | 0 | 6 | 10 | 16 | 0 |
| 1-nitropyrene | | nitroarene | carcinogenic agent | 1982 | 2014 | 34.3 | low | 0 | 7 | 1 | 0 | 1 | 0 |
| vidarabine | | beta-D-arabinoside;
purine nucleoside | antineoplastic agent;
bacterial metabolite;
nucleoside antibiotic | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| chlorpyrifos-methyl | | chloropyridine;
organic thiophosphate | acaricide;
agrochemical;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
environmental contaminant;
insecticide;
xenobiotic | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| iodinated glycerol | | dioxolane | | 1967 | 2018 | 48.1 | low | 2 | 14 | 0 | 0 | 2 | 0 |
| laurolitsine | | aporphine alkaloid;
aromatic ether;
phenols | HIV-1 integrase inhibitor;
metabolite | 1997 | 1997 | 27.0 | medium | 0 | 0 | 1 | 0 | 0 | 0 |
| acetoxyacetylaminofluorene | | 2-acetamidofluorenes | carcinogenic agent;
mutagen | 1980 | 1980 | 44.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| 1-indanol | | aromatic alcohol;
indanes;
secondary alcohol | xenobiotic | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| n-methylaspartate | | amino dicarboxylic acid;
D-alpha-amino acid;
D-aspartic acid derivative;
secondary amino compound | neurotransmitter agent | 2006 | 2012 | 15.0 | low | 0 | 0 | 0 | 2 | 1 | 0 |
| helenalin | | cyclic ketone;
gamma-lactone;
organic heterotricyclic compound;
secondary alcohol;
sesquiterpene lactone | anti-inflammatory agent;
antineoplastic agent;
metabolite;
plant metabolite | 1981 | 1981 | 43.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| dysprosium | | f-block element atom;
lanthanoid atom | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| iridium | | cobalt group element atom;
platinum group metal atom | | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| manganese | | elemental manganese;
manganese group element atom | Escherichia coli metabolite;
micronutrient | 2004 | 2016 | 15.0 | low | 0 | 0 | 0 | 2 | 2 | 0 |
| mercury | | elemental mercury;
zinc group element atom | neurotoxin | 2007 | 2018 | 10.0 | low | 0 | 0 | 0 | 1 | 6 | 0 |
| molybdenum | | chromium group element atom | micronutrient | 1972 | 2022 | 19.0 | low | 0 | 1 | 0 | 0 | 2 | 1 |
| neon | | monoatomic neon;
noble gas atom;
p-block element atom | | 1994 | 2007 | 25.3 | low | 0 | 0 | 2 | 1 | 0 | 0 |
| niobium | | vanadium group element atom | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| osmium | | iron group element atom;
platinum group metal atom | | 1969 | 2012 | 33.5 | low | 0 | 1 | 0 | 0 | 1 | 0 |
| palladium | | metal allergen;
nickel group element atom;
platinum group metal atom | | 2003 | 2015 | 13.3 | low | 0 | 0 | 0 | 12 | 15 | 0 |
| platinum | | elemental platinum;
nickel group element atom;
platinum group metal atom | | 2018 | 2020 | 5.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| praseodymium | | f-block element atom;
lanthanoid atom | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| rhodium | | cobalt group element atom | | 1991 | 2012 | 25.0 | low | 0 | 0 | 6 | 1 | 1 | 0 |
| ruthenium | | iron group element atom;
platinum group metal atom | | 1990 | 2019 | 12.6 | low | 0 | 0 | 2 | 3 | 14 | 0 |
| silver | | copper group element atom;
elemental silver | Escherichia coli metabolite | 1972 | 2017 | 21.0 | low | 0 | 1 | 0 | 2 | 2 | 0 |
| terbium | | f-block element atom;
lanthanoid atom | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| titanium | | titanium group element atom | | 2002 | 2020 | 10.8 | low | 0 | 0 | 0 | 5 | 15 | 0 |
| argon | | monoatomic argon;
noble gas atom;
p-block element atom | food packaging gas;
neuroprotective agent | 1994 | 1995 | 29.5 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| cadmium | | cadmium molecular entity;
zinc group element atom | | 2002 | 2023 | 10.4 | low | 0 | 0 | 0 | 14 | 31 | 5 |
| cerium | | f-block element atom;
lanthanoid atom | | 2009 | 2015 | 11.0 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| chromium | | chromium group element atom;
metal allergen | micronutrient | 1955 | 2021 | 19.4 | low | 0 | 1 | 1 | 3 | 5 | 1 |
| europium | | f-block element atom;
lanthanoid atom | | 2009 | 2013 | 13.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| gadolinium | | f-block element atom;
lanthanoid atom | | 1997 | 2017 | 14.3 | low | 0 | 0 | 1 | 0 | 2 | 0 |
| gold | | copper group element atom;
elemental gold | | 1969 | 2023 | 13.0 | low | 0 | 1 | 0 | 1 | 6 | 2 |
| helium | | monoatomic helium;
noble gas atom;
s-block element atom | food packaging gas | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| vanadium | | elemental vanadium;
vanadium group element atom | micronutrient | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| zirconium | | titanium group element atom | | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| aluminum chloride | | aluminium coordination entity | Lewis acid | 1997 | 2006 | 22.5 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| cupric chloride | | copper molecular entity;
inorganic chloride | EC 5.3.3.5 (cholestenol Delta-isomerase) inhibitor | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| magnesium sulfate | | magnesium salt;
metal sulfate;
organic magnesium salt | anaesthetic;
analgesic;
anti-arrhythmia drug;
anticonvulsant;
calcium channel blocker;
cardiovascular drug;
fertilizer;
tocolytic agent | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 6-nitrochrysene | | carbopolycyclic compound | | 1982 | 2014 | 34.9 | high | 0 | 16 | 1 | 0 | 1 | 0 |
| acetylglucosamine | | N-acetyl-D-glucosamine | epitope | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| galactosamine | | D-galactosamine;
primary amino compound | toxin | 2012 | 2014 | 11.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| phosphoric acid, trisodium salt | | sodium phosphate | | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| hypochlorous acid | | chlorine oxoacid;
reactive oxygen species | EC 2.5.1.18 (glutathione transferase) inhibitor;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
human metabolite | 1992 | 1992 | 32.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| camptothecin | | delta-lactone;
pyranoindolizinoquinoline;
quinoline alkaloid;
tertiary alcohol | antineoplastic agent;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
genotoxin;
plant metabolite | 1976 | 2022 | 12.9 | low | 0 | 1 | 0 | 2 | 7 | 2 |
| ferric chloride | | iron coordination entity | astringent;
Lewis acid | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| nickel chloride | | nickel coordination entity | calcium channel blocker;
hapten | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| ferrous sulfate | | iron molecular entity;
metal sulfate | reducing agent | 2001 | 2007 | 20.0 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| sodium pyrophosphate | | inorganic sodium salt | chelator;
food emulsifier;
food thickening agent | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| bromine | | diatomic bromine | | 1971 | 2022 | 17.8 | low | 0 | 1 | 0 | 0 | 3 | 1 |
| potassium nitrate | | inorganic nitrate salt;
potassium salt | fertilizer | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| sodium sulfate | | inorganic sodium salt | | 2001 | 2008 | 19.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| magnesium phosphate (2:3) | | inorganic magnesium salt | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| tricalcium phosphate | | calcium phosphate | | 2011 | 2018 | 9.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| chromates | | chromium oxoanion;
divalent inorganic anion | oxidising agent | 1969 | 1969 | 55.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| copper sulfate | | metal sulfate | emetic;
fertilizer;
sensitiser | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| calcium sulfate | | calcium salt;
inorganic calcium salt | | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| potassium dichromate | | potassium salt | allergen;
oxidising agent;
sensitiser | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| deuterium | | dihydrogen | | 1971 | 2002 | 42.3 | low | 0 | 2 | 0 | 1 | 0 | 0 |
| fluorine | | diatomic fluorine;
gas molecular entity | NMR chemical shift reference compound | 1971 | 2022 | 19.9 | low | 0 | 4 | 0 | 8 | 5 | 2 |
| chlorine | | diatomic chlorine;
gas molecular entity | bleaching agent | 1970 | 2016 | 36.0 | low | 0 | 4 | 0 | 2 | 1 | 0 |
| cupric bromide | | | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| poloxalene | | epoxide | | 1996 | 2009 | 21.0 | low | 0 | 0 | 1 | 2 | 0 | 0 |
| ozone | | elemental molecule;
gas molecular entity;
reactive oxygen species;
triatomic oxygen | antiseptic drug;
disinfectant;
electrophilic reagent;
greenhouse gas;
mutagen;
oxidising agent;
tracer | 1985 | 2019 | 23.8 | low | 0 | 4 | 0 | 5 | 2 | 0 |
| cadmium chloride | | cadmium coordination entity | | 2001 | 2016 | 15.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| cadmium sulfate | | cadmium salt | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| n,n-dimethylphenylethylamine | | primary amine | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| trolamine salicylate | | | | 1964 | 2021 | 26.6 | low | 0 | 2 | 0 | 3 | 1 | 1 |
| rhamnose | | L-rhamnose | | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| carbendazim | | benzimidazole fungicide;
benzimidazoles;
benzimidazolylcarbamate fungicide;
carbamate ester | antifungal agrochemical;
antinematodal drug;
metabolite;
microtubule-destabilising agent | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| chrysotile | | | | 1986 | 1986 | 38.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| ancymidol | | pyrimidines;
tertiary alcohol | cellulose synthesis inhibitor;
gibberellin biosynthesis inhibitor;
plant growth retardant | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| ethionine | | S-ethylhomocysteine | antimetabolite;
carcinogenic agent | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 3-hydroxybenzo(a)pyrene | | ortho- and peri-fused polycyclic arene | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| titanium dioxide | | titanium oxides | food colouring | 2002 | 2020 | 11.2 | low | 0 | 0 | 0 | 5 | 12 | 0 |
| dechlorane plus | | | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| tris(1,3-dichloro-2-propyl)phosphate | | trialkyl phosphate | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| tiletamine hydrochloride | | | | 1993 | 2019 | 19.8 | low | 0 | 0 | 3 | 0 | 2 | 0 |
| myrmicacin | | 3-hydroxy fatty acid;
medium-chain fatty acid | antimitotic;
Escherichia coli metabolite | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 4-benzoylpyridine | | aromatic ketone | | 2004 | 2005 | 19.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| menoctone | | | | 1992 | 1992 | 32.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| n'-nitrosonornicotine | | pyridines;
pyrrolidines | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| tetradecanoylphorbol acetate | | acetate ester;
diester;
phorbol ester;
tertiary alpha-hydroxy ketone;
tetradecanoate ester | antineoplastic agent;
apoptosis inducer;
carcinogenic agent;
mitogen;
plant metabolite;
protein kinase C agonist;
reactive oxygen species generator | 1978 | 2012 | 27.9 | low | 0 | 4 | 6 | 5 | 1 | 0 |
| ethephon | | phosphonic acids | plant growth regulator | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| fluorides | | halide anion;
monoatomic fluorine | | 2008 | 2017 | 11.0 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| danazol | | 17beta-hydroxy steroid;
terminal acetylenic compound | anti-estrogen;
estrogen antagonist;
geroprotector | 2004 | 2017 | 14.5 | low | 0 | 0 | 0 | 2 | 2 | 0 |
| lisuride | | monocarboxylic acid amide | antidyskinesia agent;
antiparkinson drug;
dopamine agonist;
serotonergic agonist | 1985 | 1991 | 36.0 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| chromium | | chromium cation;
monoatomic hexacation | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| 7-oxodehydroabietic acid | | | | 1995 | 2008 | 23.4 | high | 0 | 0 | 5 | 3 | 0 | 0 |
| 1-deoxynojirimycin | | 2-(hydroxymethyl)piperidine-3,4,5-triol;
piperidine alkaloid | anti-HIV agent;
anti-obesity agent;
bacterial metabolite;
EC 3.2.1.20 (alpha-glucosidase) inhibitor;
hepatoprotective agent;
hypoglycemic agent;
plant metabolite | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| iodine | | halide anion;
monoatomic iodine | human metabolite | 1952 | 2023 | 28.7 | low | 0 | 1 | 0 | 0 | 1 | 1 |
| daunorubicin | | aminoglycoside antibiotic;
anthracycline;
p-quinones;
tetracenequinones | antineoplastic agent;
bacterial metabolite | 1995 | 2021 | 15.3 | low | 0 | 0 | 1 | 1 | 0 | 1 |
| phosphotyrosine | | L-tyrosine derivative;
non-proteinogenic L-alpha-amino acid;
O(4)-phosphotyrosine | Escherichia coli metabolite;
immunogen | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| phenyl acetate | | benzenes;
phenyl acetates | | 1948 | 2020 | 29.3 | low | 0 | 12 | 5 | 10 | 7 | 0 |
| cetylpyridinium chloride anhydrous | | chloride salt;
organic chloride salt | antiseptic drug;
surfactant | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 1,4-dioxane | | dioxane;
volatile organic compound | carcinogenic agent;
metabolite;
NMR chemical shift reference compound;
non-polar solvent | 2011 | 2018 | 9.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| ursodeoxycholic acid | | bile acid;
C24-steroid;
dihydroxy-5beta-cholanic acid | human metabolite;
mouse metabolite | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| pyrene | | ortho- and peri-fused polycyclic arene | fluorescent probe;
persistent organic pollutant | 1964 | 2023 | 13.7 | medium | 0 | 6 | 23 | 136 | 147 | 21 |
| isothiuronium | | | | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 4-methoxyamphetamine | | | | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| wr 30090 | | | | 1993 | 1993 | 31.0 | medium | 0 | 0 | 1 | 0 | 0 | 0 |
| 8-bromo cyclic adenosine monophosphate | | 3',5'-cyclic purine nucleotide;
adenyl ribonucleotide;
organobromine compound | antidepressant;
protein kinase agonist | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| alkenes | | | | 1965 | 2022 | 25.3 | low | 0 | 7 | 2 | 5 | 6 | 2 |
| glutamic acid | | glutamic acid;
glutamine family amino acid;
L-alpha-amino acid;
proteinogenic amino acid | Escherichia coli metabolite;
ferroptosis inducer;
micronutrient;
mouse metabolite;
neurotransmitter;
nutraceutical | 2003 | 2012 | 14.6 | low | 0 | 0 | 0 | 5 | 2 | 0 |
| adenylyl imidodiphosphate | | adenosine 5'-phosphate | | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| azoxymethane | | | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| sodium azide | | inorganic sodium salt | antibacterial agent;
explosive;
mitochondrial respiratory-chain inhibitor;
mutagen | 2007 | 2014 | 13.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| azides | | pseudohalide anion | mitochondrial respiratory-chain inhibitor | 1974 | 2013 | 30.5 | low | 0 | 1 | 0 | 0 | 1 | 0 |
| adenosine diphosphate ribose | | ADP-sugar | Escherichia coli metabolite;
mouse metabolite | 2009 | 2021 | 9.0 | low | 0 | 0 | 0 | 1 | 0 | 1 |
| penfluridol | | diarylmethane | | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| tramadol | | 2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol | adrenergic uptake inhibitor;
antitussive;
capsaicin receptor antagonist;
delta-opioid receptor agonist;
kappa-opioid receptor agonist;
metabolite;
mu-opioid receptor agonist;
muscarinic antagonist;
nicotinic antagonist;
NMDA receptor antagonist;
opioid analgesic;
serotonergic antagonist;
serotonin uptake inhibitor | 1987 | 1987 | 37.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| cyclopenta(c,d)pyrene | | pyrenes | | 1988 | 2000 | 30.0 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| 4,5-dihydroxy-4,5-dihydrobenzo(a)pyrene | | | | 1983 | 1983 | 41.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| 4-ethynylbiphenyl | | | | 2015 | 2015 | 9.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 |
| octachlorostyrene | | organochlorine compound | | 1986 | 1986 | 38.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| paclitaxel | | taxane diterpenoid;
tetracyclic diterpenoid | antineoplastic agent;
human metabolite;
metabolite;
microtubule-stabilising agent | 2003 | 2022 | 9.7 | low | 0 | 0 | 0 | 2 | 8 | 2 |
| paclitaxel | | taxane diterpenoid;
tetracyclic diterpenoid | antineoplastic agent;
human metabolite;
metabolite;
microtubule-stabilising agent | 2003 | 2022 | 9.9 | low | 0 | 0 | 0 | 2 | 9 | 2 |
| etoposide | | beta-D-glucoside;
furonaphthodioxole;
organic heterotetracyclic compound | antineoplastic agent;
DNA synthesis inhibitor | 1976 | 2020 | 18.7 | low | 0 | 1 | 1 | 1 | 3 | 0 |
| substance p | | peptide | neurokinin-1 receptor agonist;
neurotransmitter;
vasodilator agent | 1997 | 2014 | 17.0 | low | 0 | 0 | 1 | 1 | 1 | 0 |
| 2,5-dichlorobiphenyl | | dichlorobenzene;
dichlorobiphenyl | | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 2,4,5,2',4',5'-hexachlorobiphenyl | | hexachlorobiphenyl | | 2008 | 2015 | 12.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| 2,5,2',5'-tetrachlorobiphenyl | | dichlorobenzene;
tetrachlorobiphenyl | | 2008 | 2016 | 12.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| halofantrine | | phenanthrenes | | 1982 | 2022 | 25.7 | high | 60 | 33 | 240 | 102 | 33 | 2 |
| ribavirin | | 1-ribosyltriazole;
aromatic amide;
monocarboxylic acid amide;
primary carboxamide | anticoronaviral agent;
antiinfective agent;
antimetabolite;
antiviral agent;
EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor | 2012 | 2016 | 10.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| 6-hydroxychrysene | | hydroxychrysene | xenobiotic metabolite | 2008 | 2008 | 16.0 | medium | 0 | 0 | 0 | 1 | 0 | 0 |
| phorbol 12,13-dibutyrate | | butyrate ester;
phorbol ester;
tertiary alpha-hydroxy ketone | | 1993 | 1993 | 31.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| fluorescamine | | | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| tocainide | | monocarboxylic acid amide | anti-arrhythmia drug;
local anaesthetic;
sodium channel blocker | 1987 | 1987 | 37.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| tricyclazole | | triazolobenzothiazole | antifungal agrochemical;
melanin synthesis inhibitor | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 1,6-dinitropyrene | | pyrenes | | 1987 | 1987 | 37.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| 1-methyl-4-phenylpyridinium | | pyridinium ion | apoptosis inducer;
herbicide;
human xenobiotic metabolite;
neurotoxin | 1998 | 2022 | 17.3 | low | 0 | 0 | 1 | 4 | 0 | 1 |
| lonidamine | | dichlorobenzene;
indazoles;
monocarboxylic acid | antineoplastic agent;
antispermatogenic agent;
EC 2.7.1.1 (hexokinase) inhibitor;
geroprotector | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 2,3,7,8-tetrachlorodibenzofuran | | polychlorinated dibenzofuran | | 1994 | 1994 | 30.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| fagaronine | | benzophenanthridine alkaloid | mutagen | 1989 | 1989 | 35.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| permethrin | | cyclopropanecarboxylate ester;
cyclopropanes | agrochemical;
ectoparasiticide;
pyrethroid ester acaricide;
pyrethroid ester insecticide;
scabicide | 2006 | 2010 | 16.0 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| chlorodiphenyl (54% chlorine) | | | | 1985 | 2008 | 30.0 | low | 0 | 2 | 1 | 1 | 0 | 0 |
| quisqualic acid | | non-proteinogenic alpha-amino acid | | 1998 | 1998 | 26.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| decamethrin | | aromatic ether;
cyclopropanecarboxylate ester;
nitrile;
organobromine compound | agrochemical;
antifeedant;
calcium channel agonist;
EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor;
pyrethroid ester insecticide | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid | | chromanol;
monocarboxylic acid;
phenols | antioxidant;
ferroptosis inhibitor;
neuroprotective agent;
radical scavenger;
Wnt signalling inhibitor | 1991 | 2008 | 26.7 | low | 0 | 0 | 2 | 1 | 0 | 0 |
| pinaverium | | monoterpenoid | | 1987 | 1987 | 37.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| 7,8-dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide | | epoxide | intercalator | 1983 | 1995 | 33.8 | low | 0 | 2 | 3 | 0 | 0 | 0 |
| idarubicin | | anthracycline antibiotic;
deoxy hexoside;
monosaccharide derivative | | 1999 | 2021 | 13.8 | low | 0 | 0 | 1 | 1 | 1 | 1 |
| piperacillin | | penicillin allergen;
penicillin | antibacterial drug | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 6-nitrobenzo(a)pyrene | | ortho- and peri-fused polycyclic arene | | 1982 | 1988 | 39.2 | medium | 0 | 4 | 0 | 0 | 0 | 0 |
| 4-(n-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone | | nitrosamine;
pyridines | | 2011 | 2014 | 11.0 | low | 0 | 0 | 0 | 0 | 3 | 0 |
| nicorandil | | nitrate ester;
pyridinecarboxamide | potassium channel opener;
vasodilator agent | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| 12,14-dichlorodehydroabietic acid | | | | 1999 | 2006 | 21.5 | high | 0 | 0 | 1 | 1 | 0 | 0 |
| colforsin | | acetate ester;
cyclic ketone;
labdane diterpenoid;
organic heterotricyclic compound;
tertiary alpha-hydroxy ketone;
triol | adenylate cyclase agonist;
anti-HIV agent;
antihypertensive agent;
plant metabolite;
platelet aggregation inhibitor;
protein kinase A agonist | 1993 | 2003 | 25.3 | low | 0 | 0 | 2 | 1 | 0 | 0 |
| 1,2-dihydro-1,2-dihydroxy-5-methylchrysene | | | | 1978 | 1987 | 41.4 | high | 0 | 5 | 0 | 0 | 0 | 0 |
| 5-hydroxymethylchrysene | | | | 1981 | 1989 | 38.0 | high | 0 | 5 | 0 | 0 | 0 | 0 |
| amonafide | | isoquinolines | | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| fomesafen | | aromatic ether;
C-nitro compound;
monochlorobenzenes;
N-sulfonylcarboxamide;
organofluorine compound;
phenols | agrochemical;
EC 1.3.3.4 (protoporphyrinogen oxidase) inhibitor;
herbicide | 1967 | 2012 | 41.3 | low | 0 | 2 | 0 | 0 | 1 | 0 |
| quinpirole | | pyrazoloquinoline | dopamine agonist | 1991 | 1991 | 33.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| pravastatin | | 3-hydroxy carboxylic acid;
carbobicyclic compound;
carboxylic ester;
hydroxy monocarboxylic acid;
secondary alcohol;
statin (semi-synthetic) | anticholesteremic drug;
environmental contaminant;
metabolite;
xenobiotic | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| itraconazole | | aromatic ether;
conazole antifungal drug;
cyclic ketal;
dichlorobenzene;
dioxolane;
N-arylpiperazine;
triazole antifungal drug;
triazoles | EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor;
Hedgehog signaling pathway inhibitor;
P450 inhibitor | 1988 | 1988 | 36.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| benzo(c)phenanthrene 3,4-dihydrodiol | | | | 1980 | 2008 | 35.2 | high | 0 | 6 | 0 | 2 | 0 | 0 |
| fura-2 | | | | 2000 | 2004 | 22.0 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| crisnatol | | | | 1988 | 1989 | 35.5 | medium | 0 | 2 | 0 | 0 | 0 | 0 |
| 1,2-dihydroxy-epoxy-1,2,3,4-tetrahydro-5-methylchrysene | | | | 1983 | 1990 | 38.1 | high | 0 | 9 | 1 | 0 | 0 | 0 |
| imiquimod | | imidazoquinoline | antineoplastic agent;
interferon inducer | 2017 | 2018 | 6.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| sdz 208-912 | | | | 1991 | 1993 | 32.0 | medium | 0 | 0 | 2 | 0 | 0 | 0 |
| clopidogrel | | methyl ester;
monochlorobenzenes;
thienopyridine | anticoagulant;
P2Y12 receptor antagonist;
platelet aggregation inhibitor | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| topotecan | | pyranoindolizinoquinoline | antineoplastic agent;
EC 5.99.1.2 (DNA topoisomerase) inhibitor | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| gemcitabine | | organofluorine compound;
pyrimidine 2'-deoxyribonucleoside | antimetabolite;
antineoplastic agent;
antiviral drug;
DNA synthesis inhibitor;
EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor;
environmental contaminant;
immunosuppressive agent;
photosensitizing agent;
prodrug;
radiosensitizing agent;
xenobiotic | 2012 | 2018 | 8.7 | low | 0 | 0 | 0 | 0 | 3 | 0 |
| atorvastatin | | aromatic amide;
dihydroxy monocarboxylic acid;
monofluorobenzenes;
pyrroles;
statin (synthetic) | environmental contaminant;
xenobiotic | 2009 | 2021 | 8.0 | low | 0 | 0 | 0 | 1 | 1 | 1 |
| irinotecan | | carbamate ester;
delta-lactone;
N-acylpiperidine;
pyranoindolizinoquinoline;
ring assembly;
tertiary alcohol;
tertiary amino compound | antineoplastic agent;
apoptosis inducer;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
prodrug | 2003 | 2021 | 9.0 | low | 0 | 0 | 0 | 1 | 4 | 1 |
| valsartan | | biphenylyltetrazole;
monocarboxylic acid amide;
monocarboxylic acid | angiotensin receptor antagonist;
antihypertensive agent;
environmental contaminant;
xenobiotic | 2008 | 2010 | 15.0 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| adenosine | | adenosines;
purines D-ribonucleoside | analgesic;
anti-arrhythmia drug;
fundamental metabolite;
human metabolite;
vasodilator agent | 1983 | 2006 | 30.3 | low | 0 | 1 | 1 | 1 | 0 | 0 |
| 3-n-butylphthalide | | benzofurans | | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| vanadates | | trivalent inorganic anion;
vanadium oxoanion | EC 3.1.3.1 (alkaline phosphatase) inhibitor;
EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor;
EC 3.1.3.41 (4-nitrophenylphosphatase) inhibitor;
EC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitor | 2005 | 2020 | 10.7 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| florisil | | | | 1963 | 1963 | 61.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| dimethylhydrazines | | | | 1994 | 2009 | 22.5 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| acridine orange | | aminoacridines;
aromatic amine;
tertiary amino compound | fluorochrome;
histological dye | 2004 | 2005 | 19.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| benzylaminopurine | | 6-aminopurines | cytokinin;
plant metabolite | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| trifluoromethanesulfonic acid | | one-carbon compound;
perfluoroalkanesulfonic acid | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| sodium persulfate | | | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 3-nitroperylene | | phenanthrenes | | 1982 | 1982 | 42.0 | medium | 0 | 1 | 0 | 0 | 0 | 0 |
| trazodone hydrochloride | | hydrochloride | adrenergic antagonist;
antidepressant;
H1-receptor antagonist;
sedative;
serotonin uptake inhibitor | 2001 | 2022 | 8.7 | low | 0 | 0 | 0 | 10 | 30 | 7 |
| glucose, (beta-d)-isomer | | D-glucopyranose | epitope;
mouse metabolite | 1982 | 2020 | 18.5 | low | 1 | 1 | 5 | 8 | 9 | 0 |
| ursolic acid | | hydroxy monocarboxylic acid;
pentacyclic triterpenoid | geroprotector;
plant metabolite | 1994 | 2008 | 24.2 | low | 0 | 0 | 2 | 2 | 0 | 0 |
| thiazolyl blue | | organic bromide salt | colorimetric reagent;
dye | 2005 | 2020 | 15.1 | low | 0 | 0 | 0 | 5 | 2 | 0 |
| plerixafor | | azacycloalkane;
azamacrocycle;
benzenes;
crown amine;
secondary amino compound;
tertiary amino compound | anti-HIV agent;
antineoplastic agent;
C-X-C chemokine receptor type 4 antagonist;
immunological adjuvant | 2017 | 2020 | 5.3 | low | 0 | 0 | 0 | 0 | 3 | 0 |
| 5-methylcytosine | | methylcytosine;
pyrimidines | human metabolite | 1984 | 2013 | 25.5 | low | 0 | 1 | 0 | 0 | 1 | 0 |
| epigallocatechin gallate | | flavans;
gallate ester;
polyphenol | antineoplastic agent;
antioxidant;
apoptosis inducer;
geroprotector;
Hsp90 inhibitor;
neuroprotective agent;
plant metabolite | 1995 | 2018 | 11.6 | low | 0 | 0 | 1 | 1 | 5 | 0 |
| 2'-deoxycytidine 5'-triphosphate | | 2'-deoxycytidine phosphate;
pyrimidine 2'-deoxyribonucleoside 5'-triphosphate | Escherichia coli metabolite;
human metabolite;
mouse metabolite | 1993 | 1993 | 31.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| 25-hydroxycholesterol | | 25-hydroxy steroid;
oxysterol | human metabolite | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| salvin | | abietane diterpenoid;
carbotricyclic compound;
catechols;
monocarboxylic acid | angiogenesis modulating agent;
anti-inflammatory agent;
antineoplastic agent;
antioxidant;
apoptosis inducer;
food preservative;
HIV protease inhibitor;
plant metabolite | 1989 | 2008 | 23.0 | low | 0 | 1 | 7 | 15 | 0 | 0 |
| 1,2-distearoyllecithin | | | | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| bathocuproine | | | | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| neocuproine | | phenanthrolines | chelator;
copper chelator | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| o-(6)-methylguanine | | methylguanine | mutagen | 1996 | 1996 | 28.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| n,n-bis(trimethylsilyl)-2,2,2-trifluoroacetamide | | | | 1998 | 1998 | 26.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| pyrrolidine dithiocarbamate | | dithiocarbamic acids;
pyrrolidines | anticonvulsant;
antineoplastic agent;
geroprotector;
neuroprotective agent;
NF-kappaB inhibitor;
radical scavenger | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| peroxynitric acid | | nitrogen oxoacid | | 1998 | 2000 | 25.0 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| glutathione disulfide | | glutathione derivative;
organic disulfide | Escherichia coli metabolite;
mouse metabolite | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| simalikalactone d | | | | 1980 | 1981 | 43.5 | medium | 0 | 2 | 0 | 0 | 0 | 0 |
| fanasil, pyrimethamine drug combination | | | | 1995 | 2012 | 23.8 | low | 2 | 0 | 6 | 2 | 1 | 0 |
| triptonide | | butenolide;
cyclic ketone;
diterpene triepoxide;
organic heteroheptacyclic compound | anti-inflammatory agent;
antineoplastic agent;
immunosuppressive agent | 2000 | 2023 | 14.6 | medium | 0 | 0 | 1 | 4 | 3 | 1 |
| quassin | | triterpenoid | | 1975 | 1988 | 40.1 | high | 0 | 8 | 0 | 0 | 0 | 0 |
| naphthalimides | | | | 2000 | 2021 | 11.0 | low | 0 | 0 | 2 | 0 | 3 | 1 |
| benzeneboronic acid | | boronic acids | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| laurosept | | | | 2009 | 2013 | 12.7 | medium | 0 | 0 | 0 | 1 | 2 | 0 |
| 4,7-phenanthroline | | phenanthroline | | 1959 | 1959 | 65.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| 1,7-phenanthroline | | phenanthroline | | 1951 | 2021 | 27.3 | low | 0 | 23 | 16 | 20 | 26 | 2 |
| triazoles | | 1,2,3-triazole | | 1951 | 2020 | 21.1 | low | 0 | 2 | 1 | 3 | 5 | 0 |
| pinocembrin | | (2S)-flavan-4-one;
dihydroxyflavanone | antineoplastic agent;
antioxidant;
metabolite;
neuroprotective agent;
vasodilator agent | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| isocoumarins | | isocoumarins | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| dimidium | | | | 1952 | 1952 | 72.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| delphinidin | | anthocyanidin chloride | | 1974 | 2005 | 34.5 | low | 0 | 1 | 0 | 1 | 0 | 0 |
| 4-aminoquinoline | | | | 1992 | 1993 | 31.5 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| floxacrine | | | | 1992 | 1992 | 32.0 | medium | 0 | 0 | 1 | 0 | 0 | 0 |
| artemisinin | | organic peroxide;
sesquiterpene lactone | antimalarial;
plant metabolite | 1988 | 2012 | 24.6 | low | 0 | 1 | 13 | 7 | 1 | 0 |
| artemether | | artemisinin derivative;
cyclic acetal;
organic peroxide;
semisynthetic derivative;
sesquiterpenoid | antimalarial | 1993 | 2011 | 24.5 | low | 0 | 0 | 6 | 1 | 1 | 0 |
| 1,4-anthraquinone | | | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| perfluorooctanesulfonamide | | perfluorinated compound;
sulfonamide | persistent organic pollutant | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| allyltrimethylsilane | | | | 2019 | 2019 | 5.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 |
| dibenzocycloheptadiene | | | | 1964 | 1964 | 60.0 | medium | 0 | 1 | 0 | 0 | 0 | 0 |
| 9-nitrophenanthrene | | | | 1984 | 2023 | 23.5 | high | 0 | 2 | 2 | 0 | 1 | 1 |
| 5-hydroxymethylcytosine | | aminopyrimidine;
aromatic primary alcohol;
nucleobase analogue;
pyrimidone | human metabolite;
mouse metabolite | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| cromakalim | | | | 1993 | 1993 | 31.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| masoprocol | | nordihydroguaiaretic acid | antineoplastic agent;
hypoglycemic agent;
lipoxygenase inhibitor;
metabolite | 1991 | 1997 | 29.4 | low | 0 | 0 | 5 | 0 | 0 | 0 |
| bufuralol | | benzofurans | | 1995 | 1997 | 27.7 | low | 0 | 0 | 3 | 0 | 0 | 0 |
| efaroxan | | 1-benzofurans | | 1998 | 1998 | 26.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| 7-hydroxystaurosporine | | | | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| magnolol | | biphenyls | | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| betulin | | diol;
pentacyclic triterpenoid | analgesic;
anti-inflammatory agent;
antineoplastic agent;
antiviral agent;
metabolite | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| tubulosine | | beta-carbolines;
isoquinoline alkaloid;
isoquinolines;
phenols;
secondary amino compound;
tertiary amino compound | | 1977 | 1977 | 47.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| narciclasine | | phenanthridines | metabolite | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| juncusol | | | | 1977 | 2022 | 20.2 | high | 0 | 4 | 0 | 1 | 5 | 1 |
| lycoricidine | | phenanthridines | | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| tetrandrine | | bisbenzylisoquinoline alkaloid;
isoquinolines | | 1994 | 2009 | 20.3 | low | 0 | 0 | 1 | 2 | 0 | 0 |
| chaparrinone | | triterpenoid | | 1980 | 1985 | 42.0 | high | 0 | 3 | 0 | 0 | 0 | 0 |
| brusatol | | triterpenoid | | 1981 | 1984 | 41.8 | low | 0 | 4 | 0 | 0 | 0 | 0 |
| taxodione | | diterpenoid | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| ceric oxide | | cerium molecular entity;
metal oxide | | 2009 | 2015 | 12.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| fluoren-9-ol | | hydroxyfluorenes;
secondary alcohol | animal metabolite | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| perfluorooctane sulfonic acid | | perfluoroalkanesulfonic acid | antilipemic drug;
persistent organic pollutant | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 2,5-bis(hydroxymethyl)furan | | diol;
furans | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| atovaquone | | hydroxy-1,2-naphthoquinone | | 1999 | 2020 | 17.0 | low | 1 | 0 | 1 | 1 | 1 | 0 |
| 2-hydroxyfluorene | | fluorenes | | 2010 | 2012 | 13.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| 1-hydroxybenzotriazole | | benzotriazoles | | 1998 | 2004 | 23.0 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| c.i. direct red 80 | | organic sodium salt | fluorochrome;
histological dye | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 4,4'-dipyridyl disulfide | | organic disulfide;
pyridines | | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| rosiglitazone | | aminopyridine;
thiazolidinediones | EC 6.2.1.3 (long-chain-fatty-acid--CoA ligase) inhibitor;
ferroptosis inhibitor;
insulin-sensitizing drug | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 2-n-nonyl-1,3-dioxolane | | | | 2007 | 2007 | 17.0 | medium | 0 | 0 | 0 | 1 | 0 | 0 |
| n-hydroxysuccinimide | | | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 2-bromobenzaldehyde | | | | 2015 | 2015 | 9.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 |
| 4-hydroxyphenanthrene | | phenanthrol | | 1994 | 2019 | 11.6 | high | 0 | 0 | 1 | 0 | 6 | 0 |
| dichlorquinazine | | | | 1985 | 1985 | 39.0 | high | 0 | 2 | 0 | 0 | 0 | 0 |
| benzoylmetronidazole | | benzoate ester | antibacterial drug;
antimicrobial agent;
antiparasitic agent;
antitrichomonal drug;
prodrug | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| coenzyme a | | adenosine 3',5'-bisphosphate | coenzyme;
Escherichia coli metabolite;
mouse metabolite | 1969 | 1999 | 47.3 | low | 0 | 6 | 1 | 0 | 0 | 0 |
| fenozan | | | | 1997 | 1997 | 27.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| dihydroisotanshinone i | | | | 1984 | 2021 | 12.5 | high | 0 | 1 | 0 | 1 | 4 | 2 |
| nicotine | | 3-(1-methylpyrrolidin-2-yl)pyridine | anxiolytic drug;
biomarker;
immunomodulator;
mitogen;
neurotoxin;
nicotinic acetylcholine receptor agonist;
peripheral nervous system drug;
phytogenic insecticide;
plant metabolite;
psychotropic drug;
teratogenic agent;
xenobiotic | 1968 | 2022 | 23.8 | low | 1 | 3 | 4 | 4 | 4 | 1 |
| fibrinogen | | iditol | fungal metabolite | 2009 | 2015 | 12.0 | low | 1 | 0 | 0 | 1 | 2 | 0 |
| aucubin | | organic molecular entity | metabolite | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 5-bromouridine | | uridines | mutagen | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| goethite | | | | 2009 | 2020 | 8.0 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| inermin | | maackiain | | 1986 | 1986 | 38.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| acid green 50 | | | | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| homocysteine | | amino acid zwitterion;
homocysteine;
serine family amino acid | fundamental metabolite;
mouse metabolite | 2004 | 2012 | 16.3 | low | 0 | 0 | 0 | 2 | 1 | 0 |
| n-acetoxy-4-acetylaminobiphenyl | | | | 1980 | 1980 | 44.0 | medium | 0 | 1 | 0 | 0 | 0 | 0 |
| tylophorine | | organic heteropentacyclic compound;
organonitrogen heterocyclic compound | | 1979 | 2021 | 14.7 | high | 0 | 3 | 2 | 23 | 27 | 1 |
| maleopimaric acid | | | | 1992 | 1992 | 32.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| elemol | | olefinic compound;
sesquiterpenoid;
tertiary alcohol | fragrance;
plant metabolite | 1986 | 1986 | 38.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| 4-cyano-4'-pentylbiphenyl | | | | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| cryptopleurine | | alkaloid antibiotic;
alkaloid;
aromatic ether;
organic heteropentacyclic compound | antineoplastic agent;
antiviral agent;
protein synthesis inhibitor | 1974 | 2015 | 28.0 | high | 0 | 4 | 0 | 1 | 4 | 0 |
| totarol | | diterpenoid | metabolite | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| dextromoramide | | morpholines;
N-acylpyrrolidine | opioid analgesic | 1968 | 1968 | 56.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| podocarpic acid | | abietane diterpenoid | | 1984 | 2008 | 25.1 | high | 0 | 1 | 5 | 3 | 0 | 0 |
| glycidyl nitrate | | | | 1989 | 2004 | 29.7 | low | 0 | 1 | 1 | 1 | 0 | 0 |
| dehydroabietic acid | | abietane diterpenoid;
carbotricyclic compound;
monocarboxylic acid | allergen;
metabolite | 1963 | 2023 | 21.5 | medium | 0 | 2 | 11 | 17 | 4 | 2 |
| glucuronic acid | | D-glucuronic acid | algal metabolite | 1995 | 2015 | 17.2 | low | 0 | 0 | 1 | 2 | 1 | 0 |
| 2,2',4,4'-tetrabromodiphenyl ether | | aromatic ether;
organobromine compound | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| ro 2-7239 | | | | 1960 | 1961 | 63.5 | high | 0 | 2 | 0 | 0 | 0 | 0 |
| 9,10-phenanthrenequinone monoxime | | | | 1984 | 1984 | 40.0 | medium | 0 | 1 | 0 | 0 | 0 | 0 |
| allenolic acid | | naphthols | | 1997 | 1997 | 27.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| aristolactam i | | | | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| atherospermine | | alkaloid | | 1993 | 2013 | 20.7 | high | 0 | 0 | 1 | 1 | 1 | 0 |
| 10-hydroxycamptothecin | | pyranoindolizinoquinoline | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 3-methoxybenzamide | | | | 1995 | 1995 | 29.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| 1-hydroxyphenanthrene | | phenanthrol | mouse metabolite | 1994 | 2020 | 11.2 | high | 0 | 0 | 1 | 1 | 10 | 0 |
| allocryptopine | | aromatic ether;
cyclic acetal;
cyclic ketone;
dibenzazecine alkaloid;
organic heterotetracyclic compound;
tertiary amino compound | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 1,4-phenanthrenequinone | | | | 1997 | 2017 | 16.1 | high | 0 | 0 | 2 | 2 | 4 | 0 |
| diosgenin | | 3beta-sterol;
hexacyclic triterpenoid;
sapogenin;
spiroketal | antineoplastic agent;
antiviral agent;
apoptosis inducer;
metabolite | 2006 | 2016 | 13.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| 9,10-dihydroxy-9,10-dihydrophenanthrene | | dihydrophenanthrenediol | | 1983 | 2017 | 24.0 | high | 0 | 1 | 0 | 0 | 1 | 0 |
| syringaresinol | | aromatic ether;
furofuran;
lignan;
polyether;
polyphenol | plant metabolite | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| arctiin | | glycoside;
lignan | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| effusol | | | | 2018 | 2022 | 4.2 | high | 0 | 0 | 0 | 0 | 4 | 1 |
| n-(3,5-dinitrobenzoyl)leucine | | | | 1986 | 1986 | 38.0 | medium | 0 | 1 | 0 | 0 | 0 | 0 |
| l-phenylalanine ethylester | | | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| cobalt | | cobalt group element atom;
metal allergen | micronutrient | 1987 | 2019 | 20.0 | low | 0 | 1 | 1 | 2 | 2 | 0 |
| p-methoxy-n-methylphenethylamine | | aromatic ether;
secondary amino compound | metabolite | 1982 | 1994 | 36.0 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| 1,2-bis(2-aminophenoxy)ethane-n,n,n',n'-tetraacetic acid | | polyamino carboxylic acid;
tetracarboxylic acid | chelator | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| tert-butylbicyclophosphorothionate | | organic thiophosphate | | 1992 | 1993 | 31.5 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| u 73122 | | aromatic ether;
aza-steroid;
maleimides | EC 3.1.4.11 (phosphoinositide phospholipase C) inhibitor | 1996 | 2000 | 26.0 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| plicatic acid | | lignan | | 1989 | 1989 | 35.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| 4-(methylnitrosamino)-1-(3-pyridyl)-1-butan-1-ol | | nitrosamine;
pyridines;
secondary alcohol | biomarker;
carcinogenic agent;
human urinary metabolite | 2006 | 2014 | 13.2 | low | 0 | 0 | 0 | 2 | 3 | 0 |
| 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine | | hydroxylamine;
imidazopyridine | carcinogenic agent;
genotoxin;
human xenobiotic metabolite;
mouse metabolite;
mutagen;
neurotoxin;
rat metabolite | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1h-imidazole | | ether;
imidazoles;
monomethoxybenzene | TRP channel blocker | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 9,10-epoxy-9,10-dihydrophenanthrene | | phenanthrene oxide | | 1965 | 2018 | 30.2 | high | 0 | 4 | 3 | 1 | 2 | 0 |
| benz(j)aceanthrylene | | phenanthrenes | | 1984 | 1984 | 40.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| paxilline | | diterpene alkaloid;
enone;
organic heterohexacyclic compound;
terpenoid indole alkaloid;
tertiary alcohol | anticonvulsant;
Aspergillus metabolite;
EC 3.6.3.8 (Ca(2+)-transporting ATPase) inhibitor;
genotoxin;
geroprotector;
mycotoxin;
Penicillium metabolite;
potassium channel blocker | 2009 | 2011 | 14.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| paxilline | | diterpene alkaloid;
enone;
organic heterohexacyclic compound;
terpenoid indole alkaloid;
tertiary alcohol | anticonvulsant;
Aspergillus metabolite;
EC 3.6.3.8 (Ca(2+)-transporting ATPase) inhibitor;
genotoxin;
geroprotector;
mycotoxin;
Penicillium metabolite;
potassium channel blocker | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| benzo(a)pyrene-7,8-dione | | orthoquinones;
pyrenes | genotoxin;
xenobiotic metabolite | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| artesunic acid | | | | 1993 | 2013 | 22.1 | low | 1 | 0 | 3 | 3 | 1 | 0 |
| cyanates | | | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 4-hydroxydebrisoquin | | carboxamidine;
isoquinolines;
secondary alcohol | metabolite | 1998 | 1998 | 26.0 | low | 1 | 0 | 1 | 0 | 0 | 0 |
| 15,16-dihydrocyclopenta(a)phenanthren-17-one | | | | 1976 | 1995 | 38.5 | high | 0 | 1 | 1 | 0 | 0 | 0 |
| pyronaridine | | aminoquinoline | | 1990 | 1999 | 28.2 | low | 1 | 0 | 5 | 0 | 0 | 0 |
| aceanthrylene | | ortho- and peri-fused polycyclic arene | | 2000 | 2000 | 24.0 | medium | 0 | 0 | 1 | 0 | 0 | 0 |
| epicatechin gallate | | catechin;
gallate ester;
polyphenol | EC 3.2.1.1 (alpha-amylase) inhibitor;
EC 3.2.1.20 (alpha-glucosidase) inhibitor;
metabolite | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| phosphites | | phosphite ion;
trivalent inorganic anion | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| hydroxycotinine | | N-alkylpyrrolidine;
pyridines;
pyrrolidin-2-ones;
pyrrolidine alkaloid | | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| fingolimod hydrochloride | | hydrochloride | immunosuppressive agent;
prodrug;
sphingosine-1-phosphate receptor agonist | 2011 | 2020 | 8.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| triptolide | | diterpenoid;
epoxide;
gamma-lactam;
organic heteroheptacyclic compound | antispermatogenic agent;
plant metabolite | 1972 | 2023 | 10.8 | high | 6 | 7 | 31 | 275 | 624 | 116 |
| 3,5-dihydroxyphenylglycine | | alpha-amino acid | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| nopaline | | amino acid opine;
D-glutamic acid derivative;
guanidines;
L-arginine derivative;
secondary amino compound;
tricarboxylic acid | | 1995 | 1995 | 29.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| tesmilifene | | diarylmethane | | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| schizandrin b | | | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 1-hexadecyl-2-acetyl-glycero-3-phosphocholine | | 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine | antihypertensive agent;
beta-adrenergic antagonist;
bronchoconstrictor agent;
hematologic agent;
vasodilator agent | 1989 | 2005 | 25.5 | low | 0 | 1 | 3 | 2 | 0 | 0 |
| aristolochic acid ii | | aristolochic acids;
aromatic ether;
C-nitro compound;
cyclic acetal;
monocarboxylic acid;
organic heterotetracyclic compound | carcinogenic agent;
metabolite;
mutagen;
nephrotoxin;
toxin | 1984 | 2000 | 35.1 | high | 0 | 7 | 4 | 0 | 0 | 0 |
| 1,2-epoxy-3,4-dihydroxy-1,2,3,4-tetrahydrobenzo(c)phenanthrene | | | | 1980 | 2006 | 28.2 | high | 0 | 1 | 22 | 5 | 0 | 0 |
| deoxyglucose | | | | 1985 | 1985 | 39.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| chrysene,2-diol-3,4-epoxide-1 | | | | 1982 | 1995 | 37.6 | high | 0 | 9 | 2 | 0 | 0 | 0 |
| territrem b | | | | 2013 | 2014 | 10.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| trans-1,2-dihydro-1,2-naphthalenediol | | trans-1,2-dihydronaphthalene-1,2-diol | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 1,5(10)-estradiene-3,4,17-trione | | 17-oxo steroid;
3-oxo-Delta(1) steroid;
orthoquinones | human metabolite | 1996 | 1996 | 28.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| dodecyl-beta-d-maltoside | | disaccharide derivative;
glycoside | detergent | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| aporphine | | aporphine alkaloid;
isoquinoline alkaloid fundamental parent;
tertiary amino compound | | 1996 | 2021 | 17.5 | low | 0 | 0 | 2 | 2 | 1 | 1 |
| tanshinone | | abietane diterpenoid | anticoronaviral agent | 1980 | 2023 | 17.3 | high | 1 | 16 | 35 | 313 | 65 | 7 |
| mefloquine-sulfadoxine-pyrimethamine | | | | 1995 | 1995 | 29.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| benzyloxyresorufin | | | | 1996 | 1996 | 28.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| 2-ethynylnaphthalene | | | | 1992 | 2000 | 28.0 | medium | 0 | 0 | 3 | 0 | 0 | 0 |
| perloline | | | | 1945 | 1992 | 52.8 | high | 0 | 4 | 1 | 0 | 0 | 0 |
| gastrodin | | glycoside | | 2014 | 2016 | 9.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| 1,3-dichloro-6-trifluoromethyl-9-phenanthryl-3-(n-butyl)aminopropanol | | | | 1984 | 2009 | 26.8 | high | 4 | 2 | 22 | 8 | 0 | 0 |
| benzo(g)chrysene-11,12-dihydrodiol-13,14-epoxide | | | | 1995 | 1998 | 28.0 | high | 0 | 0 | 3 | 0 | 0 | 0 |
| brassinolide | | 22-hydroxy steroid;
23-hydroxy steroid;
2alpha-hydroxy steroid;
3alpha-hydroxy steroid;
brassinosteroid | plant growth stimulator;
plant hormone | 2012 | 2013 | 11.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| 3'-o-(4-benzoyl)benzoyladenosine 5'-triphosphate | | purine ribonucleoside triphosphate | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane | | | | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| benzoperylene | | | | 1994 | 1994 | 30.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| culmorin | | | | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| tafenoquine | | (trifluoromethyl)benzenes;
aminoquinoline;
aromatic ether;
primary amino compound;
secondary amino compound | | 1991 | 2000 | 29.0 | low | 1 | 0 | 4 | 0 | 0 | 0 |
| glyceraldehyde 3-phosphate dehydrogenase (304-313) | | | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| s-(3-hydroxypropyl)cysteine n-acetate | | N-acyl-L-amino acid | | 2018 | 2018 | 6.0 | low | 1 | 0 | 0 | 0 | 1 | 0 |
| lithospermate b | | | | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 3,4-dihydroxyphenylacetaldehyde | | alpha-CH2-containing aldehyde;
catechols;
phenylacetaldehydes | Escherichia coli metabolite;
human metabolite;
mouse metabolite | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| dioscin | | hexacyclic triterpenoid;
spiroketal;
spirostanyl glycoside;
trisaccharide derivative | anti-inflammatory agent;
antifungal agent;
antineoplastic agent;
antiviral agent;
apoptosis inducer;
EC 1.14.18.1 (tyrosinase) inhibitor;
hepatoprotective agent;
metabolite | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| bw 245c | | imidazolidine-2,4-dione;
monocarboxylic acid;
secondary alcohol | | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| caprylates | | fatty acid anion 8:0;
straight-chain saturated fatty acid anion | human metabolite;
Saccharomyces cerevisiae metabolite | 2007 | 2017 | 12.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| aristolic acid | | | | 1982 | 1993 | 38.2 | high | 0 | 3 | 1 | 0 | 0 | 0 |
| dibenz(a,h)anthracene-3,4-diol 1,2-oxide | | | | 1995 | 1995 | 29.0 | medium | 0 | 0 | 1 | 0 | 0 | 0 |
| pramipexole | | benzothiazoles;
diamine | antidyskinesia agent;
antiparkinson drug;
dopamine agonist;
radical scavenger | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 1,2-dihydroxy-5,6-dimethyl-3,4-epoxy-1,2,3,4-tetrahydrochrysene | | | | 1993 | 1993 | 31.0 | medium | 0 | 0 | 1 | 0 | 0 | 0 |
| wr 99210 | | | | 1984 | 1997 | 34.3 | low | 0 | 2 | 1 | 0 | 0 | 0 |
| desethylamodiaquine | | | | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| tenax | | | | 2004 | 2014 | 15.2 | low | 0 | 0 | 0 | 3 | 2 | 0 |
| muristerone a | | | | 1998 | 1998 | 26.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| piperaquine | | aminoquinoline;
N-arylpiperazine;
organochlorine compound | antimalarial | 1985 | 2020 | 22.8 | low | 0 | 2 | 0 | 0 | 2 | 0 |
| aj 76 | | secondary amino compound;
tetralins | dopaminergic antagonist | 1986 | 1986 | 38.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| celastrol | | monocarboxylic acid;
pentacyclic triterpenoid | anti-inflammatory drug;
antineoplastic agent;
antioxidant;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
Hsp90 inhibitor;
metabolite | 2002 | 2023 | 9.4 | low | 0 | 0 | 0 | 5 | 11 | 2 |
| bruceine d | | | | 1981 | 1981 | 43.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| benzyne | | aryne;
benzyne | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| carbene | | carbene;
methanediyl | | 2002 | 2014 | 16.5 | low | 0 | 0 | 0 | 2 | 2 | 0 |
| peroxynitrous acid | | nitrogen oxoacid | | 2002 | 2010 | 18.2 | low | 0 | 0 | 0 | 5 | 0 | 0 |
| diethylaminosulfur trifluoride | | | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| fullerene c60 | | fullerene | geroprotector | 1997 | 2015 | 14.2 | low | 0 | 0 | 1 | 3 | 5 | 0 |
| imatinib mesylate | | methanesulfonate salt | anticoronaviral agent;
antineoplastic agent;
apoptosis inducer;
tyrosine kinase inhibitor | 2009 | 2021 | 10.4 | low | 0 | 0 | 0 | 3 | 5 | 1 |
| gefitinib | | aromatic ether;
monochlorobenzenes;
monofluorobenzenes;
morpholines;
quinazolines;
secondary amino compound;
tertiary amino compound | antineoplastic agent;
epidermal growth factor receptor antagonist | 2015 | 2021 | 5.2 | low | 0 | 0 | 0 | 0 | 3 | 1 |
| 5-hydroxy-1-methyl-2--(di-n-propylamino)tetralin methyl ether | | | | 1986 | 1986 | 38.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| n,n-dimethylarginine | | dimethylarginine;
guanidines;
L-arginine derivative;
non-proteinogenic L-alpha-amino acid | EC 1.14.13.39 (nitric oxide synthase) inhibitor | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| dodecyloctaethyleneglycol monoether | | hydroxypolyether | | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| peroxyoxalate | | | | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| e 64 | | dicarboxylic acid monoamide;
epoxy monocarboxylic acid;
guanidines;
L-leucine derivative;
zwitterion | antimalarial;
antiparasitic agent;
protease inhibitor | 1998 | 1998 | 26.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| 8,9-dihydro-8,9-dihydroxybenzanthracene 10,11-oxide | | | | 1980 | 1980 | 44.0 | medium | 0 | 1 | 0 | 0 | 0 | 0 |
| 1,1,2-triphenylbut-1-ene | | | | 1987 | 1987 | 37.0 | medium | 0 | 1 | 0 | 0 | 0 | 0 |
| hw 165 | | | | 1985 | 1993 | 36.4 | high | 0 | 6 | 2 | 0 | 0 | 0 |
| 3-(4-(4-phenyl-1,2,3,6-tetrahydropyridyl-1)-butyl)indole | | | | 1993 | 1993 | 31.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| n-(3,5-dinitrobenzoyl)phenylglycine | | | | 1986 | 1986 | 38.0 | medium | 0 | 1 | 0 | 0 | 0 | 0 |
| methotrexate | | dicarboxylic acid;
monocarboxylic acid amide;
pteridines | abortifacient;
antimetabolite;
antineoplastic agent;
antirheumatic drug;
dermatologic drug;
DNA synthesis inhibitor;
EC 1.5.1.3 (dihydrofolate reductase) inhibitor;
immunosuppressive agent | 2006 | 2021 | 8.4 | low | 1 | 0 | 0 | 1 | 3 | 1 |
| 1,2-dihydroxy-3,4-epoxy-1,2,3,4-tetrahydro-6-methylchrysene | | | | 1986 | 1990 | 36.0 | high | 0 | 2 | 1 | 0 | 0 | 0 |
| clausenamide | | | | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| wr 194965 | | | | 1988 | 1991 | 35.0 | high | 0 | 2 | 1 | 0 | 0 | 0 |
| 7-ethoxy-4-trifluoromethylcoumarin | | | | 1995 | 1995 | 29.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| sauristolactam | | | | 1997 | 2010 | 19.5 | high | 0 | 0 | 1 | 3 | 0 | 0 |
| purpactin a | | | | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| haloquinone | | | | 1981 | 2021 | 23.0 | high | 0 | 2 | 0 | 0 | 0 | 2 |
| metakelfin | | | | 1995 | 1995 | 29.0 | low | 1 | 0 | 1 | 0 | 0 | 0 |
| wr 242511 | | | | 1992 | 1992 | 32.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| alpha-ergocryptine | | ergot alkaloid | | 1992 | 1992 | 32.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| xylose | | D-xylose | | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| ethynylpyridine | | | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| proline | | amino acid zwitterion;
glutamine family amino acid;
L-alpha-amino acid;
proline;
proteinogenic amino acid | algal metabolite;
compatible osmolytes;
Escherichia coli metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite | 2008 | 2019 | 11.0 | low | 0 | 0 | 0 | 2 | 3 | 0 |
| cucurbitaceae | | | | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| tris-(1,10-phenanthroline)ruthenium | | | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| bis(phenanthroline)(phenanthrenequinone diimine)rhodium(iii) | | | | 1992 | 1999 | 28.5 | high | 0 | 0 | 8 | 0 | 0 | 0 |
| docetaxel anhydrous | | secondary alpha-hydroxy ketone;
tetracyclic diterpenoid | antimalarial;
antineoplastic agent;
photosensitizing agent | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| tariquidar | | benzamides | | 2013 | 2015 | 10.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| n-(2,6-dimethylergoline-8-yl)-2,2-dimethylpropanamide | | | | 1993 | 1993 | 31.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| levofloxacin | | 9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid;
fluoroquinolone antibiotic;
quinolone antibiotic | antibacterial drug;
DNA synthesis inhibitor;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
topoisomerase IV inhibitor | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| tanshinone vi | | | | 1994 | 2010 | 20.6 | high | 0 | 0 | 1 | 4 | 0 | 0 |
| molybdenum chloride | | | | 2012 | 2014 | 11.0 | medium | 0 | 0 | 0 | 0 | 2 | 0 |
| 3,4-dihydroxy-1,2-epoxy-1,2,3,4-tetrahydrobenz(a)anthracene | | | | 1980 | 1991 | 38.3 | medium | 0 | 2 | 1 | 0 | 0 | 0 |
| moxifloxacin | | aromatic ether;
cyclopropanes;
fluoroquinolone antibiotic;
pyrrolidinopiperidine;
quinolinemonocarboxylic acid;
quinolone antibiotic;
quinolone | antibacterial drug | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 1-ethynylpyrene | | | | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| naproxen | | methoxynaphthalene;
monocarboxylic acid | antipyretic;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
drug allergen;
environmental contaminant;
gout suppressant;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
xenobiotic | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| hydroxyl radical | | oxygen hydride;
oxygen radical;
reactive oxygen species | | 2003 | 2022 | 14.0 | low | 0 | 0 | 0 | 6 | 3 | 1 |
| wilforlide a | | | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| tripchlorolide | | | | 1990 | 2022 | 21.1 | high | 0 | 0 | 17 | 14 | 6 | 1 |
| sodium percarbonate | | | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| singlet oxygen | | chalcogen;
monoatomic oxygen;
nonmetal atom | macronutrient | 2009 | 2011 | 14.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| bruceine a | | quassinoid | | 1980 | 1985 | 41.5 | medium | 0 | 2 | 0 | 0 | 0 | 0 |
| miltirone | | abietane diterpenoid | | 1991 | 2022 | 10.9 | high | 0 | 0 | 2 | 3 | 18 | 2 |
| aloesin | | chromones | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| cryptotanshinone | | abietane diterpenoid | anticoronaviral agent | 1983 | 2023 | 10.4 | high | 0 | 6 | 6 | 79 | 192 | 40 |
| fenton's reagent | | | | 2004 | 2014 | 14.5 | low | 0 | 0 | 0 | 5 | 3 | 0 |
| coclaurine | | coclaurine | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| cyclocolorenone | | | | 1986 | 1986 | 38.0 | medium | 0 | 1 | 0 | 0 | 0 | 0 |
| testololactone | | 3-oxo-Delta(4) steroid;
seco-androstane;
steroid lactone | | 1963 | 1963 | 61.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| prostaglandins b | | | | 1985 | 1992 | 35.5 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| stephenanthrine | | cyclic acetal;
organic heterotetracyclic compound;
tertiary amino compound | | 1986 | 2003 | 29.5 | high | 0 | 1 | 0 | 1 | 0 | 0 |
| bruceine b | | triterpenoid | | 1980 | 1980 | 44.0 | medium | 0 | 1 | 0 | 0 | 0 | 0 |
| ampelopsin | | dihydromyricetin;
secondary alpha-hydroxy ketone | antineoplastic agent;
antioxidant;
metabolite | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| corydalmine | | | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| tylophorinidine | | | | 2001 | 2012 | 17.5 | high | 0 | 0 | 0 | 1 | 1 | 0 |
| aristololactam bii | | | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 15-hydroperoxyabietic acid | | | | 1988 | 1988 | 36.0 | medium | 0 | 1 | 0 | 0 | 0 | 0 |
| 4-(2'-pyridyldithio)benzyldiazoacetate | | | | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| tetraphenylphosphonium | | heteroorganic entity;
phosphorus molecular entity;
polyatomic cation | | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| aristolochic acid c | | aristolochic acids;
aromatic ether;
C-nitro compound;
cyclic acetal;
monocarboxylic acid;
organic heterotetracyclic compound | carcinogenic agent;
metabolite;
mutagen;
nephrotoxin;
toxin | 1994 | 1994 | 30.0 | medium | 0 | 0 | 1 | 0 | 0 | 0 |
| desosamine | | amino sugar | | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 1,2-diphytanoylphosphatidylcholine | | | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| biotin | | biotins;
vitamin B7 | coenzyme;
cofactor;
Escherichia coli metabolite;
fundamental metabolite;
human metabolite;
mouse metabolite;
nutraceutical;
prosthetic group;
Saccharomyces cerevisiae metabolite | 2001 | 2018 | 12.2 | low | 0 | 0 | 0 | 1 | 3 | 0 |
| angiotensin ii | | amino acid zwitterion;
angiotensin II | human metabolite | 2002 | 2019 | 13.8 | low | 0 | 0 | 0 | 14 | 6 | 0 |
| methyl abietate | | | | 1980 | 2002 | 33.0 | high | 0 | 1 | 1 | 1 | 0 | 0 |
| triptophenolide | | oxo steroid | | 2000 | 2016 | 17.0 | medium | 0 | 0 | 1 | 1 | 1 | 0 |
| wr 184806 | | | | 1988 | 1998 | 31.0 | high | 0 | 1 | 2 | 0 | 0 | 0 |
| atropine | | | | 1970 | 1970 | 54.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| ruthenium-tris-1,4,5,8-tetraazaphenanthrene | | | | 1992 | 2019 | 16.9 | high | 0 | 0 | 2 | 3 | 3 | 0 |
| cypripedin | | phenanthrol | | 2020 | 2020 | 4.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 |
| lignin | | | | 1991 | 2022 | 17.8 | low | 0 | 0 | 4 | 5 | 4 | 1 |
| ropivacaine | | piperidinecarboxamide;
ropivacaine | local anaesthetic | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| dendrophenol | | | | 1994 | 2020 | 16.0 | low | 0 | 0 | 1 | 1 | 1 | 0 |
| sb 203580 | | imidazoles;
monofluorobenzenes;
pyridines;
sulfoxide | EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor;
EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor;
geroprotector;
Hsp90 inhibitor;
neuroprotective agent | 2004 | 2012 | 14.8 | low | 0 | 0 | 0 | 2 | 2 | 0 |
| sb 216763 | | indoles;
maleimides | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| organophosphonates | | divalent inorganic anion;
phosphite ion | | 2000 | 2000 | 24.0 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| 9-ethynylphenanthrene | | | | 1995 | 2015 | 21.7 | high | 0 | 0 | 4 | 0 | 2 | 0 |
| 6-acetonyldihydrochelerythrine | | | | 2003 | 2020 | 12.4 | high | 0 | 0 | 0 | 2 | 3 | 0 |
| aflatoxin b1 | | aflatoxin;
aromatic ether;
aromatic ketone | carcinogenic agent;
human metabolite | 1984 | 2013 | 20.2 | low | 0 | 1 | 1 | 2 | 2 | 0 |
| methyl-1alpha, 7alpha-dihydroxy-3-oxopregn-4-en-21-oate | | | | 1962 | 1962 | 62.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| beauverolides | | | | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| annetocin | | | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| hydrastine | | isoquinolines | metabolite | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| lapatinib | | furans;
organochlorine compound;
organofluorine compound;
quinazolines | antineoplastic agent;
tyrosine kinase inhibitor | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| sorafenib | | (trifluoromethyl)benzenes;
aromatic ether;
monochlorobenzenes;
phenylureas;
pyridinecarboxamide | angiogenesis inhibitor;
anticoronaviral agent;
antineoplastic agent;
EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor;
ferroptosis inducer;
tyrosine kinase inhibitor | 2014 | 2021 | 6.2 | low | 0 | 0 | 0 | 0 | 4 | 1 |
| pimaric acid | | diterpenoid | | 1999 | 2016 | 17.2 | medium | 0 | 0 | 1 | 3 | 2 | 0 |
| cholic acid | | 12alpha-hydroxy steroid;
3alpha-hydroxy steroid;
7alpha-hydroxy steroid;
bile acid;
C24-steroid;
trihydroxy-5beta-cholanic acid | human metabolite;
mouse metabolite | 2006 | 2014 | 14.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| sandaracopimaric acid | | monocarboxylic acid;
pimarane diterpenoid;
tricyclic diterpenoid | plant metabolite | 2006 | 2016 | 12.3 | medium | 0 | 0 | 0 | 1 | 2 | 0 |
| erythritol | | butane-1,2,3,4-tetrol | antioxidant;
human metabolite;
plant metabolite | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| deoxycholic acid | | bile acid;
C24-steroid;
dihydroxy-5beta-cholanic acid | human blood serum metabolite | 1974 | 2013 | 35.0 | low | 0 | 2 | 0 | 0 | 1 | 0 |
| delrin | | | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| cortisone | | 11-oxo steroid;
17alpha-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
C21-steroid;
glucocorticoid;
primary alpha-hydroxy ketone;
tertiary alpha-hydroxy ketone | human metabolite;
mouse metabolite | 1965 | 1965 | 59.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| adrenosterone | | 11-oxo steroid;
17-oxo steroid;
3-oxo-Delta(4) steroid;
androstanoid | androgen;
EC 1.1.1.146 (11beta-hydroxysteroid dehydrogenase) inhibitor;
human urinary metabolite;
marine metabolite | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 1-keto-1,2,3,4-tetrahydrophenanthrene | | | | 2000 | 2011 | 19.0 | high | 0 | 0 | 1 | 6 | 1 | 0 |
| 1,4-phenylenebis(boronic acid) | | | | 2011 | 2011 | 13.0 | high | 0 | 0 | 0 | 0 | 2 | 0 |
| 3-nitrotyrosine | | 2-nitrophenols;
C-nitro compound;
nitrotyrosine;
non-proteinogenic alpha-amino acid | | 2002 | 2005 | 20.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| sodium sulfide | | | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| propargylamine | | | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| lanosterol | | 14alpha-methyl steroid;
3beta-sterol;
tetracyclic triterpenoid | bacterial metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| 2-hydroxyestradiol | | 17beta-hydroxy steroid;
2-hydroxy steroid | carcinogenic agent;
human metabolite;
metabolite;
mouse metabolite;
prodrug | 1995 | 1995 | 29.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| nogalamycin | | | | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| anisomycin | | monohydroxypyrrolidine;
organonitrogen heterocyclic antibiotic | anticoronaviral agent;
antimicrobial agent;
antineoplastic agent;
antiparasitic agent;
bacterial metabolite;
DNA synthesis inhibitor;
protein synthesis inhibitor | 1977 | 1977 | 47.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| benzofurans | | | | 1994 | 2021 | 14.8 | low | 0 | 0 | 3 | 20 | 13 | 1 |
| potassium bromide | | potassium salt | | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| calendula | | | | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| metribolone | | 17beta-hydroxy steroid;
3-oxo steroid;
anabolic androgenic steroid | androgen | 1984 | 1984 | 40.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| noscapine | | aromatic ether;
benzylisoquinoline alkaloid;
cyclic acetal;
isobenzofuranone;
organic heterobicyclic compound;
organic heterotricyclic compound;
tertiary amino compound | antineoplastic agent;
antitussive;
apoptosis inducer;
plant metabolite | 2014 | 2015 | 9.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| glaucarubinone | | | | 1980 | 1987 | 41.3 | high | 0 | 3 | 0 | 0 | 0 | 0 |
| homoharringtonine | | alkaloid ester;
enol ether;
organic heteropentacyclic compound;
tertiary alcohol | anticoronaviral agent;
antineoplastic agent;
apoptosis inducer;
protein synthesis inhibitor | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| tripdiolide | | oxacycle | | 1972 | 2014 | 23.2 | high | 0 | 2 | 2 | 4 | 2 | 0 |
| wortmannin | | acetate ester;
cyclic ketone;
delta-lactone;
organic heteropentacyclic compound | anticoronaviral agent;
antineoplastic agent;
autophagy inhibitor;
EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor;
geroprotector;
Penicillium metabolite;
radiosensitizing agent | 1996 | 2010 | 18.0 | low | 0 | 0 | 1 | 4 | 0 | 0 |
| 2-oxindole | | gamma-lactam;
indolinone | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| lariciresinol | | aromatic ether;
lignan;
oxolanes;
phenols;
primary alcohol | antifungal agent;
plant metabolite | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| anthricin | | furonaphthodioxole;
gamma-lactone;
lignan;
methoxybenzenes | antineoplastic agent;
apoptosis inducer;
plant metabolite | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| trimethoprim, sulfamethoxazole drug combination | | | | 1995 | 1995 | 29.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| sampangine | | alkaloid;
organic heterotetracyclic compound | antifungal agent;
plant metabolite | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| bortezomib | | amino acid amide;
L-phenylalanine derivative;
pyrazines | antineoplastic agent;
antiprotozoal drug;
protease inhibitor;
proteasome inhibitor | 2008 | 2013 | 13.0 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| ritonavir | | 1,3-thiazoles;
carbamate ester;
carboxamide;
L-valine derivative;
ureas | antiviral drug;
environmental contaminant;
HIV protease inhibitor;
xenobiotic | 2013 | 2018 | 8.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| bardoxolone methyl | | cyclohexenones | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| dihydropyridines | | | | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| permanganate | | manganese oxoacid | | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| leupeptins | | | | 2011 | 2020 | 8.0 | low | 0 | 0 | 0 | 0 | 3 | 0 |
| carboplatin | | | | 2008 | 2016 | 11.3 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| nsc 259,968 | | | | 1982 | 1982 | 42.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| lithium chloride | | inorganic chloride;
lithium salt | antimanic drug;
geroprotector | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| glycogen | | | | 2016 | 2019 | 6.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| arabinose | | L-arabinose | Escherichia coli metabolite;
mouse metabolite | 1994 | 1994 | 30.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| fibrin | | peptide | | 1998 | 2015 | 17.5 | low | 0 | 0 | 1 | 0 | 1 | 0 |
| bradykinin | | oligopeptide | human blood serum metabolite;
vasodilator agent | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| canavanine | | amino acid zwitterion;
non-proteinogenic L-alpha-amino acid | phytogenic insecticide;
plant metabolite | 1984 | 2008 | 28.0 | low | 0 | 1 | 0 | 1 | 0 | 0 |
| hexacyanoferrate iii | | | | 1992 | 2017 | 19.5 | low | 0 | 0 | 1 | 0 | 1 | 0 |
| glucosamine | | D-glucosamine | Escherichia coli metabolite;
geroprotector;
mouse metabolite | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| carnosine | | amino acid zwitterion;
dipeptide | anticonvulsant;
antineoplastic agent;
antioxidant;
Daphnia magna metabolite;
geroprotector;
human metabolite;
mouse metabolite;
neuroprotective agent | 1992 | 2013 | 25.0 | low | 0 | 0 | 2 | 0 | 1 | 0 |
| mevalonic acid | | 3,5-dihydroxy-3-methylpentanoic acid | | 1968 | 1971 | 54.7 | low | 0 | 3 | 0 | 0 | 0 | 0 |
| raffinose | | raffinose family oligosaccharide;
trisaccharide | mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| naringenin | | (2S)-flavan-4-one;
naringenin | expectorant;
plant metabolite | 2006 | 2022 | 7.7 | low | 0 | 0 | 0 | 1 | 0 | 2 |
| oxytocin | | heterodetic cyclic peptide;
peptide hormone | oxytocic;
vasodilator agent | 1971 | 2009 | 31.2 | low | 0 | 1 | 2 | 1 | 0 | 0 |
| 3,4-dihydroxyphenyllactic acid | | 2-hydroxy monocarboxylic acid;
catechols | | 1990 | 2016 | 17.9 | low | 0 | 0 | 2 | 10 | 2 | 0 |
| inositol 1,4,5-trisphosphate | | myo-inositol trisphosphate | mouse metabolite | 1997 | 1999 | 26.0 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| cysteinylglycine | | dipeptide zwitterion;
dipeptide | Escherichia coli metabolite;
human metabolite;
Saccharomyces cerevisiae metabolite | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| ouabain | | 11alpha-hydroxy steroid;
14beta-hydroxy steroid;
5beta-hydroxy steroid;
alpha-L-rhamnoside;
cardenolide glycoside;
steroid hormone | anti-arrhythmia drug;
cardiotonic drug;
EC 2.3.3.1 [citrate (Si)-synthase] inhibitor;
EC 3.1.3.41 (4-nitrophenylphosphatase) inhibitor;
EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor;
EC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitor;
ion transport inhibitor;
plant metabolite | 1967 | 2020 | 39.2 | low | 0 | 4 | 1 | 0 | 1 | 0 |
| salicin | | aromatic primary alcohol;
aryl beta-D-glucoside;
benzyl alcohols | antipyretic;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
metabolite;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
prodrug | 2001 | 2002 | 22.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| puromycin | | puromycins | antiinfective agent;
antimicrobial agent;
antineoplastic agent;
EC 3.4.11.14 (cytosol alanyl aminopeptidase) inhibitor;
EC 3.4.14.2 (dipeptidyl-peptidase II) inhibitor;
nucleoside antibiotic;
protein synthesis inhibitor | 1996 | 1996 | 28.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| tartaric acid | | tartaric acid | Escherichia coli metabolite | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| nicotinamide-beta-riboside | | N-glycosylnicotinamide;
pyridine nucleoside | geroprotector;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| adenosine 5'-o-(3-thiotriphosphate) | | nucleoside triphosphate analogue | | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| cortodoxone | | deoxycortisol;
glucocorticoid;
primary alpha-hydroxy ketone;
tertiary alpha-hydroxy ketone | human metabolite;
mouse metabolite | 1999 | 2006 | 20.5 | low | 0 | 0 | 1 | 3 | 0 | 0 |
| pr toxin | | oxacycle | | 1982 | 1982 | 42.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| strychnine | | monoterpenoid indole alkaloid;
organic heteroheptacyclic compound | avicide;
cholinergic antagonist;
glycine receptor antagonist;
neurotransmitter agent;
rodenticide | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| quinidine | | cinchona alkaloid | alpha-adrenergic antagonist;
anti-arrhythmia drug;
antimalarial;
drug allergen;
EC 1.14.13.181 (13-deoxydaunorubicin hydroxylase) inhibitor;
EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor;
muscarinic antagonist;
P450 inhibitor;
potassium channel blocker;
sodium channel blocker | 1971 | 2010 | 27.9 | low | 0 | 3 | 3 | 5 | 0 | 0 |
| griseofulvin | | 1-benzofurans;
antibiotic antifungal drug;
benzofuran antifungal drug;
organochlorine compound;
oxaspiro compound | antibacterial agent;
Penicillium metabolite | 2004 | 2018 | 14.0 | low | 0 | 0 | 0 | 2 | 2 | 0 |
| monensin | | cyclic hemiketal;
monocarboxylic acid;
polyether antibiotic;
spiroketal | antifungal agent;
coccidiostat;
ionophore | 1979 | 1979 | 45.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| pentazocine | | benzazocine | | 1968 | 1971 | 54.5 | low | 0 | 4 | 0 | 0 | 0 | 0 |
| terconazole | | 1-(4-{[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)-4-isopropylpiperazine | | 1951 | 1951 | 73.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| pancratistatin | | citraconoyl group | | 2002 | 2013 | 16.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| chaparrin | | triterpenoid | | 1986 | 1986 | 38.0 | medium | 0 | 1 | 0 | 0 | 0 | 0 |
| glaucarubolone | | triterpenoid | | 1980 | 1985 | 41.5 | high | 0 | 2 | 0 | 0 | 0 | 0 |
| ginsenoside rg1 | | 12beta-hydroxy steroid;
3beta-hydroxy-4,4-dimethylsteroid;
beta-D-glucoside;
ginsenoside;
tetracyclic triterpenoid | neuroprotective agent;
pro-angiogenic agent | 2008 | 2010 | 15.0 | low | 0 | 0 | 0 | 3 | 0 | 0 |
| notoginsenoside r1 | | 12beta-hydroxy steroid;
3beta-hydroxy-4,4-dimethylsteroid;
3beta-hydroxy steroid;
beta-D-glucoside;
disaccharide derivative;
ginsenoside;
tetracyclic triterpenoid | antioxidant;
apoptosis inducer;
neuroprotective agent;
phytoestrogen;
plant metabolite | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| carnosol | | diterpenoid | | 1991 | 2016 | 23.0 | high | 0 | 0 | 16 | 27 | 1 | 0 |
| isopimaric acid | | carbotricyclic compound;
diterpenoid;
monocarboxylic acid | | 1996 | 2021 | 15.2 | high | 0 | 0 | 3 | 12 | 10 | 1 |
| cephaelin | | pyridoisoquinoline | | 1977 | 1977 | 47.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| amantadine hydrochloride | | isoquinoline alkaloid | | 1963 | 2011 | 26.8 | high | 0 | 1 | 0 | 2 | 1 | 0 |
| lubimin | | vetispirane sesquiterpenoid | antifungal agent;
phytoalexin | 1986 | 1986 | 38.0 | medium | 0 | 1 | 0 | 0 | 0 | 0 |
| pulegone | | p-menth-4(8)-en-3-one | | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| ochratoxin a | | isochromanes;
monocarboxylic acid amide;
N-acyl-L-phenylalanine;
organochlorine compound;
phenylalanine derivative | Aspergillus metabolite;
calcium channel blocker;
carcinogenic agent;
mycotoxin;
nephrotoxin;
Penicillium metabolite;
teratogenic agent | 2000 | 2001 | 23.5 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| juliflorine | | citraconoyl group | | 2005 | 2005 | 19.0 | medium | 0 | 0 | 0 | 1 | 0 | 0 |
| lusianthridin | | dihydrophenanthrene | | 2005 | 2023 | 5.3 | high | 0 | 0 | 0 | 1 | 6 | 5 |
| lignans | | | | 1989 | 2016 | 19.1 | low | 0 | 1 | 1 | 4 | 3 | 0 |
| 2-c-methylerythritol 4-phosphate | | tetritol phosphate | Escherichia coli metabolite | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| n-formylmethionine leucyl-phenylalanine | | tripeptide | | 1992 | 2011 | 22.0 | low | 0 | 0 | 1 | 1 | 1 | 0 |
| abieta-7(8),13(14)-diene | | abietadiene | | 1996 | 2000 | 26.0 | high | 0 | 0 | 2 | 0 | 0 | 0 |
| sodium arsenite | | arsenic molecular entity;
inorganic sodium salt | antibacterial agent;
antifungal agent;
antineoplastic agent;
carcinogenic agent;
herbicide;
insecticide;
rodenticide | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| trispheridine | | phenanthridines | | 2013 | 2013 | 11.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 |
| 7-deoxypancratistatin | | phenanthridines | | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| daunorubicinol | | 13-dihydrodaunorubicin | | 1995 | 1995 | 29.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| ergonovine | | ergot alkaloid;
monocarboxylic acid amide;
organic heterotetracyclic compound;
primary alcohol;
secondary amino compound;
tertiary amino compound | diagnostic agent;
fungal metabolite;
oxytocic;
toxin | 1992 | 1992 | 32.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| dironyl | | organic molecular entity | | 1985 | 1991 | 36.0 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| erythromycin ethylsuccinate | | cyclic ketone;
erythromycin derivative;
ethyl ester;
succinate ester | | 1974 | 1974 | 50.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| betadex | | cyclodextrin | | 1992 | 2022 | 15.5 | low | 0 | 0 | 1 | 21 | 9 | 1 |
| acetyl coenzyme a | | acyl-CoA | acyl donor;
coenzyme;
effector;
fundamental metabolite | 1973 | 2019 | 28.0 | low | 0 | 1 | 0 | 0 | 1 | 0 |
| e-z cinnamic acid | | cinnamic acid | plant metabolite | 1985 | 2022 | 18.0 | low | 0 | 1 | 0 | 2 | 0 | 1 |
| trichostatin a | | antibiotic antifungal agent;
hydroxamic acid;
trichostatin | bacterial metabolite;
EC 3.5.1.98 (histone deacetylase) inhibitor;
geroprotector | 2009 | 2014 | 12.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| tretinoin | | retinoic acid;
vitamin A | anti-inflammatory agent;
antineoplastic agent;
antioxidant;
AP-1 antagonist;
human metabolite;
keratolytic drug;
retinoic acid receptor agonist;
retinoid X receptor agonist;
signalling molecule | 1994 | 2017 | 17.5 | low | 0 | 0 | 2 | 8 | 3 | 0 |
| arachidonic acid | | icosa-5,8,11,14-tetraenoic acid;
long-chain fatty acid;
omega-6 fatty acid | Daphnia galeata metabolite;
EC 3.1.1.1 (carboxylesterase) inhibitor;
human metabolite;
mouse metabolite | 1989 | 2008 | 26.9 | low | 0 | 1 | 20 | 7 | 0 | 0 |
| alpha-cyclodextrin | | cyclodextrin | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| fumaric acid | | butenedioic acid | food acidity regulator;
fundamental metabolite;
geroprotector | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| prostaglandin h2 | | olefinic compound;
oxylipin;
prostaglandins H;
secondary alcohol | mouse metabolite | 1985 | 1985 | 39.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| 3-hydroxy-3-methylglutaryl-coenzyme a | | 3-hydroxy-3-methylglutaryl-CoA;
3-hydroxy fatty acyl-CoA | human metabolite;
mouse metabolite | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| resveratrol | | resveratrol | antioxidant;
phytoalexin;
plant metabolite;
quorum sensing inhibitor;
radical scavenger | 2012 | 2021 | 8.5 | low | 0 | 0 | 0 | 0 | 9 | 1 |
| retinol | | retinol;
vitamin A | human metabolite;
mouse metabolite;
plant metabolite | 1968 | 2006 | 39.2 | low | 0 | 3 | 0 | 2 | 0 | 0 |
| cyanoginosin lr | | microcystin | bacterial metabolite;
EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor;
environmental contaminant;
xenobiotic | 2019 | 2021 | 4.3 | low | 0 | 0 | 0 | 0 | 2 | 1 |
| oleic acid | | octadec-9-enoic acid | antioxidant;
Daphnia galeata metabolite;
EC 3.1.1.1 (carboxylesterase) inhibitor;
Escherichia coli metabolite;
mouse metabolite;
plant metabolite;
solvent | 2001 | 2018 | 16.0 | low | 0 | 0 | 0 | 5 | 3 | 0 |
| tacrolimus | | macrolide lactam | bacterial metabolite;
immunosuppressive agent | 1999 | 2016 | 18.6 | low | 0 | 0 | 1 | 6 | 1 | 0 |
| ferric hydroxide | | | | 2012 | 2013 | 11.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| ferulic acid | | ferulic acids | anti-inflammatory agent;
antioxidant;
apoptosis inhibitor;
cardioprotective agent;
MALDI matrix material;
plant metabolite | 2004 | 2018 | 15.7 | low | 0 | 0 | 0 | 5 | 1 | 0 |
| 1,5-dihydro-fad | | flavin adenine dinucleotide | Escherichia coli metabolite;
mouse metabolite | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| cocaine | | benzoate ester;
methyl ester;
tertiary amino compound;
tropane alkaloid | adrenergic uptake inhibitor;
central nervous system stimulant;
dopamine uptake inhibitor;
environmental contaminant;
local anaesthetic;
mouse metabolite;
plant metabolite;
serotonin uptake inhibitor;
sodium channel blocker;
sympathomimetic agent;
vasoconstrictor agent;
xenobiotic | 1993 | 2022 | 18.7 | low | 0 | 0 | 3 | 3 | 2 | 1 |
| cocaine | | benzoate ester;
methyl ester;
tertiary amino compound;
tropane alkaloid | adrenergic uptake inhibitor;
central nervous system stimulant;
dopamine uptake inhibitor;
environmental contaminant;
local anaesthetic;
mouse metabolite;
plant metabolite;
serotonin uptake inhibitor;
sodium channel blocker;
sympathomimetic agent;
vasoconstrictor agent;
xenobiotic | 1993 | 2022 | 18.2 | low | 1 | 0 | 3 | 6 | 2 | 1 |
| eicosapentaenoic acid | | icosapentaenoic acid;
omega-3 fatty acid | anticholesteremic drug;
antidepressant;
antineoplastic agent;
Daphnia galeata metabolite;
fungal metabolite;
micronutrient;
mouse metabolite;
nutraceutical | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| thapsigargin | | butyrate ester;
organic heterotricyclic compound;
sesquiterpene lactone | calcium channel blocker;
EC 3.6.3.8 (Ca(2+)-transporting ATPase) inhibitor | 1999 | 2014 | 18.6 | low | 0 | 0 | 2 | 1 | 2 | 0 |
| mycophenolic acid | | 2-benzofurans;
gamma-lactone;
monocarboxylic acid;
phenols | anticoronaviral agent;
antimicrobial agent;
antineoplastic agent;
EC 1.1.1.205 (IMP dehydrogenase) inhibitor;
environmental contaminant;
immunosuppressive agent;
mycotoxin;
Penicillium metabolite;
xenobiotic | 2008 | 2010 | 15.0 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| clindamycin | | | | 1994 | 1994 | 30.0 | low | 1 | 0 | 1 | 0 | 0 | 0 |
| zithromax | | macrolide antibiotic | antibacterial drug;
environmental contaminant;
xenobiotic | 1995 | 1995 | 29.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| geranylgeranyl pyrophosphate | | geranylgeranyl diphosphate | mouse metabolite | 1994 | 2015 | 22.3 | low | 0 | 0 | 2 | 0 | 1 | 0 |
| isofagomine | | piperidines | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| y 27632 | | aromatic amide | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| prostaglandin d2 | | prostaglandins D | human metabolite;
mouse metabolite | 1985 | 2011 | 22.4 | low | 0 | 1 | 0 | 3 | 1 | 0 |
| diethylstilbestrol | | olefinic compound;
polyphenol | antifungal agent;
antineoplastic agent;
autophagy inducer;
calcium channel blocker;
carcinogenic agent;
EC 1.1.1.146 (11beta-hydroxysteroid dehydrogenase) inhibitor;
EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor;
endocrine disruptor;
xenoestrogen | 1962 | 1976 | 55.5 | low | 0 | 8 | 0 | 0 | 0 | 0 |
| h 89 | | N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide | | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| afimoxifene | | phenols;
tertiary amino compound | antineoplastic agent;
estrogen receptor antagonist;
metabolite | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| decitabine | | 2'-deoxyribonucleoside | | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| steviol | | bridged compound;
ent-kaurane diterpenoid;
monocarboxylic acid;
tertiary allylic alcohol;
tetracyclic diterpenoid | antineoplastic agent | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| dactinomycin | | actinomycin | mutagen | 1994 | 2021 | 21.8 | low | 0 | 0 | 3 | 0 | 0 | 1 |
| gamma-sitosterol | | 3beta-hydroxy-Delta(5)-steroid;
3beta-sterol;
phytosterols | marine metabolite;
plant metabolite | 1996 | 2020 | 16.9 | low | 0 | 0 | 1 | 4 | 3 | 0 |
| aphidicolin | | tetracyclic diterpenoid | antimicrobial agent;
antimitotic;
antineoplastic agent;
antiviral drug;
apoptosis inducer;
Aspergillus metabolite;
DNA synthesis inhibitor;
EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor;
fungal metabolite | 1993 | 1993 | 31.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| melphalan | | L-phenylalanine derivative;
nitrogen mustard;
non-proteinogenic L-alpha-amino acid;
organochlorine compound | alkylating agent;
antineoplastic agent;
carcinogenic agent;
drug allergen;
immunosuppressive agent | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| benzyloxycarbonylleucyl-leucyl-leucine aldehyde | | amino aldehyde;
carbamate ester;
tripeptide | proteasome inhibitor | 2011 | 2020 | 8.0 | low | 0 | 0 | 0 | 0 | 3 | 0 |
| schizandrin | | | | 1991 | 2014 | 21.5 | low | 0 | 0 | 1 | 0 | 1 | 0 |
| shikonin | | hydroxy-1,4-naphthoquinone | | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| dihydrochelerythrine | | benzophenanthridine alkaloid | | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| riboflavin | | flavin;
vitamin B2 | anti-inflammatory agent;
antioxidant;
cofactor;
Escherichia coli metabolite;
food colouring;
fundamental metabolite;
human urinary metabolite;
mouse metabolite;
photosensitizing agent;
plant metabolite | 2015 | 2023 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| o,o-diacetyl tartaric acid anhydride | | | | 1995 | 1995 | 29.0 | medium | 0 | 0 | 1 | 0 | 0 | 0 |
| potassium permanganate | | | | 2008 | 2009 | 15.3 | low | 0 | 0 | 0 | 3 | 0 | 0 |
| sodium bicarbonate | | one-carbon compound;
organic sodium salt | antacid;
food anticaking agent | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| sodium acetate, anhydrous | | organic sodium salt | NMR chemical shift reference compound | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| ammonium acetate | | acetate salt;
ammonium salt | buffer;
food acidity regulator | 2006 | 2011 | 15.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| 11-mercaptoundecanoic acid | | | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| wr 243251 | | | | 1992 | 1992 | 32.0 | medium | 0 | 0 | 1 | 0 | 0 | 0 |
| diphenylbutadiene | | | | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| tolfenamic acid | | aminobenzoic acid;
organochlorine compound;
secondary amino compound | EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
EC 2.7.1.33 (pantothenate kinase) inhibitor;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| methyl triclosan | | | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 7-hydroxy-2-methoxy-1,4-phenanthrenedione | | | | 2001 | 2018 | 16.0 | high | 0 | 0 | 0 | 2 | 1 | 0 |
| trans-4-coumaric acid | | 4-coumaric acid | food component;
mouse metabolite;
plant metabolite | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| glycosides | | | | 1968 | 2019 | 42.8 | low | 0 | 34 | 0 | 1 | 7 | 0 |
| benzylideneacetone | | benzylideneacetone | bacterial metabolite;
EC 3.1.1.4 (phospholipase A2) inhibitor;
flavouring agent;
fragrance | 1994 | 1994 | 30.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| chalcone | | chalcone | EC 3.2.1.1 (alpha-amylase) inhibitor | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| isomethyleugenol | | isomethyleugenol | | 1949 | 2015 | 33.2 | low | 0 | 11 | 2 | 7 | 3 | 0 |
| retinaldehyde | | retinal;
vitamin A | gap junctional intercellular communication inhibitor;
human metabolite;
mouse metabolite | 2005 | 2006 | 18.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| squalene | | triterpene | human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite | 1968 | 1971 | 54.5 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| stilbenes | | stilbene | | 1947 | 2021 | 27.6 | low | 0 | 19 | 6 | 14 | 17 | 1 |
| isoliquiritigenin | | chalcones | antineoplastic agent;
biological pigment;
EC 1.14.18.1 (tyrosinase) inhibitor;
GABA modulator;
geroprotector;
metabolite;
NMDA receptor antagonist | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| coumestan | | coumestans;
delta-lactone | phytoestrogen;
plant metabolite | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| phenyl-n-tert-butylnitrone | | | | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| antofine | | alkaloid antibiotic;
alkaloid;
aromatic ether;
organic heteropentacyclic compound | angiogenesis inhibitor;
anti-inflammatory agent;
antimicrobial agent;
antineoplastic agent;
antiviral agent;
phytotoxin;
plant metabolite | 2006 | 2021 | 10.6 | medium | 0 | 0 | 0 | 2 | 7 | 1 |
| prolinol | | | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| cardamonin | | chalcones | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| flavin-adenine dinucleotide | | flavin adenine dinucleotide;
vitamin B2 | cofactor;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
prosthetic group | 2013 | 2015 | 10.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| cannabidiol | | olefinic compound;
phytocannabinoid;
resorcinols | antimicrobial agent;
plant metabolite | 2019 | 2022 | 3.5 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| pyrophosphate | | diphosphate ion | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| polidocanol | | hydroxypolyether | hepatotoxic agent;
nonionic surfactant;
sclerotherapy agent | 1986 | 2016 | 17.4 | low | 0 | 1 | 0 | 6 | 4 | 0 |
| fludarabine | | purine nucleoside | | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| dithizone | | | | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| sesquiterpenes | | | | 1974 | 2018 | 25.6 | low | 3 | 5 | 22 | 13 | 2 | 0 |
| vasicine | | | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| ag-213 | | | | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| armepavine | | | | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| thiobenzamide | | benzenes | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| caffeic acid | | caffeic acid | geroprotector;
mouse metabolite | 2003 | 2020 | 15.0 | low | 0 | 0 | 0 | 3 | 2 | 0 |
| loline | | loline alkaloid;
secondary amino compound | | 1992 | 1992 | 32.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| 4-acetylaminostilbene | | | | 1993 | 1997 | 29.0 | medium | 0 | 0 | 4 | 0 | 0 | 0 |
| cotinine | | N-alkylpyrrolidine;
pyridines;
pyrrolidin-2-ones;
pyrrolidine alkaloid | antidepressant;
biomarker;
human xenobiotic metabolite;
plant metabolite | 1990 | 2022 | 18.4 | low | 0 | 0 | 3 | 3 | 2 | 1 |
| phenanthraquinone monothiosemicarbazone | | | | 1987 | 2002 | 25.4 | high | 0 | 1 | 0 | 4 | 0 | 0 |
| curcumin | | aromatic ether;
beta-diketone;
diarylheptanoid;
enone;
polyphenol | anti-inflammatory agent;
antifungal agent;
antineoplastic agent;
biological pigment;
contraceptive drug;
dye;
EC 1.1.1.205 (IMP dehydrogenase) inhibitor;
EC 1.1.1.21 (aldehyde reductase) inhibitor;
EC 1.1.1.25 (shikimate dehydrogenase) inhibitor;
EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitor;
EC 1.8.1.9 (thioredoxin reductase) inhibitor;
EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor;
EC 3.5.1.98 (histone deacetylase) inhibitor;
flavouring agent;
food colouring;
geroprotector;
hepatoprotective agent;
immunomodulator;
iron chelator;
ligand;
lipoxygenase inhibitor;
metabolite;
neuroprotective agent;
nutraceutical;
radical scavenger | 1995 | 2021 | 15.0 | low | 0 | 0 | 1 | 4 | 2 | 1 |
| nootkatone | | carbobicyclic compound;
enone;
sesquiterpenoid | fragrance;
insect repellent;
plant metabolite | 1986 | 1986 | 38.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| methimazole | | 1,3-dihydroimidazole-2-thiones | antithyroid drug | 1972 | 1972 | 52.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| cinnarizine | | diarylmethane;
N-alkylpiperazine;
olefinic compound | anti-allergic agent;
antiemetic;
calcium channel blocker;
geroprotector;
H1-receptor antagonist;
histamine antagonist;
muscarinic antagonist | 2004 | 2017 | 14.5 | low | 0 | 0 | 0 | 2 | 2 | 0 |
| capsaicin | | capsaicinoid | non-narcotic analgesic;
TRPV1 agonist;
voltage-gated sodium channel blocker | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| enclomiphene | | | | 1974 | 1986 | 44.0 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| chlorogenic acid | | cinnamate ester;
tannin | food component;
plant metabolite | 2007 | 2023 | 8.0 | low | 0 | 0 | 0 | 1 | 1 | 1 |
| longifolene | | longifolene | | 1986 | 1986 | 38.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| thioguanine anhydrous | | 2-aminopurines | anticoronaviral agent;
antimetabolite;
antineoplastic agent | 1985 | 2014 | 20.3 | low | 0 | 1 | 0 | 0 | 2 | 0 |
| thiourea | | one-carbon compound;
thioureas;
ureas | antioxidant;
chromophore | 1969 | 1983 | 48.0 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| indigo carmine | | | | 2000 | 2012 | 18.7 | low | 0 | 0 | 1 | 1 | 1 | 0 |
| digoxin | | cardenolide glycoside;
steroid saponin | anti-arrhythmia drug;
cardiotonic drug;
EC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitor;
epitope | 1974 | 2020 | 16.6 | low | 0 | 1 | 0 | 2 | 4 | 0 |
| 1,6-anhydro-beta-glucopyranose | | anhydrohexose | Arabidopsis thaliana metabolite;
biomarker;
human metabolite | 2006 | 2019 | 12.3 | low | 0 | 0 | 0 | 2 | 1 | 0 |
| tamoxifen | | stilbenoid;
tertiary amino compound | angiogenesis inhibitor;
antineoplastic agent;
bone density conservation agent;
EC 1.2.3.1 (aldehyde oxidase) inhibitor;
EC 2.7.11.13 (protein kinase C) inhibitor;
estrogen antagonist;
estrogen receptor antagonist;
estrogen receptor modulator | 1993 | 2008 | 22.2 | low | 0 | 0 | 2 | 2 | 0 | 0 |
| nadp | | | | 1974 | 2021 | 25.7 | low | 0 | 3 | 11 | 4 | 4 | 1 |
| 1,1-diphenyl-2-picrylhydrazyl | | | | 2001 | 2018 | 16.6 | low | 0 | 0 | 0 | 6 | 2 | 0 |
| horminone | | | | 1994 | 1994 | 30.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| methyl-thiohydantoin-tryptophan | | organonitrogen compound;
organooxygen compound | | 2010 | 2019 | 9.2 | low | 0 | 0 | 0 | 1 | 4 | 0 |
| fusidic acid | | 11alpha-hydroxy steroid;
3alpha-hydroxy steroid;
alpha,beta-unsaturated monocarboxylic acid;
steroid acid;
steroid antibiotic;
sterol ester | EC 2.7.1.33 (pantothenate kinase) inhibitor;
Escherichia coli metabolite;
protein synthesis inhibitor | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| artemotil | | artemisinin derivative | | 1993 | 1993 | 31.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| u 0126 | | aryl sulfide;
dinitrile;
enamine;
substituted aniline | antineoplastic agent;
antioxidant;
apoptosis inducer;
EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor;
osteogenesis regulator;
vasoconstrictor agent | 2007 | 2022 | 12.6 | low | 0 | 0 | 0 | 4 | 3 | 1 |
| laccase | | | | 1998 | 2023 | 9.9 | low | 0 | 0 | 2 | 3 | 10 | 3 |
| cobaltous chloride | | cobalt salt;
inorganic chloride | allergen;
calcium channel blocker;
sensitiser;
two-colour indicator | 2006 | 2014 | 14.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| nitrogen dioxide | | nitrogen oxide | | 1980 | 1987 | 40.5 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| enpiroline | | | | 1985 | 1998 | 33.3 | high | 0 | 3 | 4 | 0 | 0 | 0 |
| orlistat | | beta-lactone;
carboxylic ester;
formamides;
L-leucine derivative | anti-obesity agent;
bacterial metabolite;
EC 2.3.1.85 (fatty acid synthase) inhibitor;
EC 3.1.1.3 (triacylglycerol lipase) inhibitor | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| quinine | | cinchona alkaloid | antimalarial;
muscle relaxant;
non-narcotic analgesic | 1973 | 2013 | 30.0 | low | 2 | 18 | 51 | 16 | 2 | 0 |
| kaurenoic acid | | | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 1,2-bis(2-aminophenoxy)ethane n,n,n',n'-tetraacetic acid acetoxymethyl ester | | | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 2,2-dimethyl-5-hydroxy-1-pyrrolidinyloxy | | | | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 11,12-dihydroxy-13,14-epoxy-11,12,13,14-tetrahydrodibenzo(a,l)pyrene | | | | 1995 | 1995 | 29.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| 7-benzyloxyquinoline | | | | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| dasatinib | | 1,3-thiazoles;
aminopyrimidine;
monocarboxylic acid amide;
N-(2-hydroxyethyl)piperazine;
N-arylpiperazine;
organochlorine compound;
secondary amino compound;
tertiary amino compound | anticoronaviral agent;
antineoplastic agent;
tyrosine kinase inhibitor | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| piperolactam a | | alkaloid | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| dipyrromethene | | dipyrrins | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| cytellin | | | | 1981 | 2020 | 19.8 | low | 0 | 1 | 1 | 4 | 3 | 0 |
| gigantol | | | | 2006 | 2020 | 8.5 | medium | 0 | 0 | 0 | 1 | 3 | 0 |
| ginsenosides | | | | 2008 | 2019 | 11.4 | low | 0 | 0 | 0 | 3 | 2 | 0 |
| ovalbumin | | | | 1997 | 2020 | 15.2 | low | 0 | 0 | 1 | 1 | 3 | 0 |
| tert-butanesulfinamide | | | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| sodium dodecyl sulfate | | organic sodium salt | detergent;
protein denaturant | 1974 | 2015 | 16.5 | low | 0 | 1 | 1 | 9 | 8 | 0 |
| sto 609 | | naphthoic acid | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| mtt formazan | | | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| l 663536 | | aryl sulfide;
indoles;
monocarboxylic acid;
monochlorobenzenes | antineoplastic agent;
EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor;
leukotriene antagonist | 1997 | 1997 | 27.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| alizarin red s | | organic sodium salt;
organosulfonate salt | histological dye | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| alpha-chymotrypsin | | | | 1967 | 1974 | 53.5 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| 17-ketosteroids | | | | 1969 | 1974 | 53.0 | low | 0 | 3 | 0 | 0 | 0 | 0 |
| naphthoquinones | | | | 1967 | 2022 | 21.0 | low | 2 | 3 | 5 | 10 | 6 | 2 |
| jhw 015 | | indolecarboxamide | | 2010 | 2012 | 13.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| am 630 | | N-acylindole | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| osteoprotegerin | | long-chain fatty acid | | 2004 | 2006 | 19.0 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| myelin basic protein | | | | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| imd 0354 | | benzamides | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 2-mercaptoacetate | | monocarboxylic acid anion | | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| sphingosine | | sphing-4-enine | human metabolite;
mouse metabolite | 1992 | 2020 | 14.8 | low | 0 | 0 | 1 | 0 | 3 | 0 |
| quercetin | | 7-hydroxyflavonol;
pentahydroxyflavone | antibacterial agent;
antineoplastic agent;
antioxidant;
Aurora kinase inhibitor;
chelator;
EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor;
geroprotector;
phytoestrogen;
plant metabolite;
protein kinase inhibitor;
radical scavenger | 1991 | 2023 | 13.9 | low | 0 | 0 | 2 | 8 | 5 | 3 |
| bilirubin | | biladienes;
dicarboxylic acid | antioxidant;
human metabolite;
mouse metabolite | 1974 | 2019 | 28.0 | low | 1 | 2 | 1 | 1 | 1 | 0 |
| dinoprostone | | prostaglandins E | human metabolite;
mouse metabolite;
oxytocic | 1985 | 2018 | 19.4 | low | 0 | 1 | 8 | 15 | 7 | 0 |
| dinoprost | | monocarboxylic acid;
prostaglandins Falpha | human metabolite;
mouse metabolite | 1985 | 2003 | 28.4 | low | 0 | 1 | 7 | 2 | 0 | 0 |
| formononetin | | 4'-methoxyisoflavones;
7-hydroxyisoflavones | phytoestrogen;
plant metabolite | 2013 | 2019 | 8.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| prostaglandin b1 | | prostaglandins B | human metabolite | 1985 | 1992 | 35.5 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| arachidonyltrifluoromethane | | fatty acid derivative;
ketone;
olefinic compound;
organofluorine compound | EC 3.1.1.4 (phospholipase A2) inhibitor | 1998 | 2001 | 24.2 | low | 0 | 0 | 2 | 2 | 0 | 0 |
| apigenin | | trihydroxyflavone | antineoplastic agent;
metabolite | 2006 | 2017 | 13.0 | low | 0 | 0 | 0 | 2 | 1 | 0 |
| luteolin | | 3'-hydroxyflavonoid;
tetrahydroxyflavone | angiogenesis inhibitor;
anti-inflammatory agent;
antineoplastic agent;
apoptosis inducer;
c-Jun N-terminal kinase inhibitor;
EC 2.3.1.85 (fatty acid synthase) inhibitor;
immunomodulator;
nephroprotective agent;
plant metabolite;
radical scavenger;
vascular endothelial growth factor receptor antagonist | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 7,3'-dihydroxy-4'-methoxyisoflavone | | 4'-methoxyisoflavones;
7-hydroxyisoflavones | antioxidant;
metabolite | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| linoleic acid | | octadecadienoic acid;
omega-6 fatty acid | algal metabolite;
Daphnia galeata metabolite;
plant metabolite | 1998 | 2002 | 23.3 | low | 0 | 0 | 1 | 2 | 0 | 0 |
| calcitriol | | D3 vitamins;
hydroxycalciol;
triol | antineoplastic agent;
antipsoriatic;
bone density conservation agent;
calcium channel agonist;
calcium channel modulator;
hormone;
human metabolite;
immunomodulator;
metabolite;
mouse metabolite;
nutraceutical | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| pinosylvin | | pinosylvin | | 1986 | 1986 | 38.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| vitamin k semiquinone radical | | | | 1990 | 1996 | 29.8 | low | 0 | 0 | 4 | 0 | 0 | 0 |
| beta carotene | | carotenoid beta-end derivative;
cyclic carotene | antioxidant;
biological pigment;
cofactor;
ferroptosis inhibitor;
human metabolite;
mouse metabolite;
plant metabolite;
provitamin A | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| leukotriene b4 | | dihydroxy monocarboxylic acid;
hydroxy polyunsaturated fatty acid;
leukotriene;
long-chain fatty acid | human metabolite;
mouse metabolite;
plant metabolite;
vasoconstrictor agent | 1989 | 2007 | 26.0 | low | 0 | 1 | 0 | 1 | 0 | 0 |
| leukotriene c4 | | leukotriene | bronchoconstrictor agent;
human metabolite;
mouse metabolite | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| maleylpyruvate | | 4,6-dioxohept-2-enedioic acid;
beta-diketone | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| thromboxane a2 | | epoxy monocarboxylic acid;
thromboxanes A | mouse metabolite | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| feruloyltyramine | | tyramines | metabolite | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 8,11,14-eicosatrienoic acid | | fatty acid 20:3;
long-chain fatty acid | fungal metabolite;
human metabolite;
nutraceutical | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| rosin | | | | 1952 | 2022 | 30.2 | low | 0 | 8 | 19 | 3 | 2 | 1 |
| alprostadil | | prostaglandins E | anticoagulant;
human metabolite;
platelet aggregation inhibitor;
vasodilator agent | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 5-hydroxy-6,8,11,14-eicosatetraenoic acid | | HETE | human metabolite;
mouse metabolite | 1997 | 1997 | 27.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| vitamin d 2 | | hydroxy seco-steroid;
seco-ergostane;
vitamin D | bone density conservation agent;
nutraceutical;
plant metabolite;
rodenticide | 1963 | 2007 | 39.0 | low | 0 | 1 | 0 | 1 | 0 | 0 |
| stigmasterol | | 3beta-hydroxy-Delta(5)-steroid;
3beta-sterol;
phytosterols;
stigmastane sterol | plant metabolite | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| rutin | | disaccharide derivative;
quercetin O-glucoside;
rutinoside;
tetrahydroxyflavone | antioxidant;
metabolite | 2004 | 2023 | 12.7 | low | 0 | 0 | 0 | 2 | 0 | 1 |
| kaempferol | | 7-hydroxyflavonol;
flavonols;
tetrahydroxyflavone | antibacterial agent;
geroprotector;
human blood serum metabolite;
human urinary metabolite;
human xenobiotic metabolite;
plant metabolite | 2006 | 2020 | 11.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| 6-ketoprostaglandin f1 alpha | | prostaglandins Falpha | human metabolite;
mouse metabolite | 1996 | 2016 | 20.0 | low | 0 | 0 | 2 | 0 | 1 | 0 |
| arachidonic acid omega-9 hydroperoxide | | HPETE | mouse metabolite | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| alpha-linolenic acid | | linolenic acid;
omega-3 fatty acid | micronutrient;
mouse metabolite;
nutraceutical | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| genistein | | 7-hydroxyisoflavones | antineoplastic agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
geroprotector;
human urinary metabolite;
phytoestrogen;
plant metabolite;
tyrosine kinase inhibitor | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| amphotericin b | | antibiotic antifungal drug;
macrolide antibiotic;
polyene antibiotic | antiamoebic agent;
antiprotozoal drug;
bacterial metabolite | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| pulmicort | | 11beta-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(1),Delta(4)-steroid;
cyclic acetal;
glucocorticoid;
primary alpha-hydroxy ketone | anti-inflammatory drug;
bronchodilator agent;
drug allergen | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| cassaine | | enoate ester;
organic hydroxy compound;
tertiary amino compound;
tricyclic diterpenoid | antihypertensive agent;
cardiotonic drug;
EC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitor;
local anaesthetic;
plant metabolite;
poison | 1976 | 1976 | 48.0 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| bruceantin | | triterpenoid | | 1978 | 1988 | 41.5 | high | 0 | 12 | 0 | 0 | 0 | 0 |
| mezerein | | diterpenoid | | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| humulene | | alpha-humulene | | 2009 | 2022 | 8.5 | low | 0 | 0 | 0 | 1 | 0 | 1 |
| zearalenone | | macrolide;
resorcinols | fungal metabolite;
mycoestrogen | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| baicalein | | trihydroxyflavone | angiogenesis inhibitor;
anti-inflammatory agent;
antibacterial agent;
anticoronaviral agent;
antifungal agent;
antineoplastic agent;
antioxidant;
apoptosis inducer;
EC 1.13.11.31 (arachidonate 12-lipoxygenase) inhibitor;
EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor;
EC 4.1.1.17 (ornithine decarboxylase) inhibitor;
ferroptosis inhibitor;
geroprotector;
hormone antagonist;
plant metabolite;
prostaglandin antagonist;
radical scavenger | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| diosmetin | | 3'-hydroxyflavonoid;
monomethoxyflavone;
trihydroxyflavone | angiogenesis inhibitor;
anti-inflammatory agent;
antineoplastic agent;
antioxidant;
apoptosis inducer;
bone density conservation agent;
cardioprotective agent;
plant metabolite;
tropomyosin-related kinase B receptor agonist;
vasodilator agent | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| fisetin | | 3'-hydroxyflavonoid;
7-hydroxyflavonol;
tetrahydroxyflavone | anti-inflammatory agent;
antioxidant;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
geroprotector;
metabolite;
plant metabolite | 1991 | 2000 | 28.5 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| hyperoside | | beta-D-galactoside;
monosaccharide derivative;
quercetin O-glycoside;
tetrahydroxyflavone | hepatoprotective agent;
plant metabolite | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| mangostin | | aromatic ether;
phenols;
xanthones | antimicrobial agent;
antineoplastic agent;
antioxidant;
plant metabolite | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| myricetin | | 7-hydroxyflavonol;
hexahydroxyflavone | antineoplastic agent;
antioxidant;
cyclooxygenase 1 inhibitor;
food component;
geroprotector;
hypoglycemic agent;
plant metabolite | 1991 | 2006 | 25.5 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| wogonin | | dihydroxyflavone;
monomethoxyflavone | angiogenesis inhibitor;
antineoplastic agent;
cyclooxygenase 2 inhibitor;
plant metabolite | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| daidzein | | 7-hydroxyisoflavones | antineoplastic agent;
EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor;
EC 3.2.1.20 (alpha-glucosidase) inhibitor;
phytoestrogen;
plant metabolite | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| rosmarinic acid | | rosmarinic acid | geroprotector;
plant metabolite | 1998 | 2021 | 12.4 | low | 0 | 0 | 1 | 5 | 6 | 1 |
| salvianolic acid a | | stilbenoid | | 2007 | 2014 | 14.3 | low | 0 | 0 | 0 | 4 | 2 | 0 |
| maytansine | | alpha-amino acid ester;
carbamate ester;
epoxide;
maytansinoid;
organic heterotetracyclic compound;
organochlorine compound | antimicrobial agent;
antimitotic;
antineoplastic agent;
plant metabolite;
tubulin modulator | 1976 | 1976 | 48.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| rottlerin | | aromatic ketone;
benzenetriol;
chromenol;
enone;
methyl ketone | anti-allergic agent;
antihypertensive agent;
antineoplastic agent;
apoptosis inducer;
K-ATP channel agonist;
metabolite | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| prostaglandin a1 | | prostaglandins A | | 1985 | 1985 | 39.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| coenzyme q10 | | ubiquinones | antioxidant;
ferroptosis inhibitor;
human metabolite | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| copalyl diphosphate | | copalyl diphosphate | | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| 4-hydroxyestradiol | | 4-hydroxy steroid | metabolite | 1995 | 1995 | 29.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| thromboxane b2 | | thromboxanes B | human metabolite;
mouse metabolite | 1997 | 2016 | 17.0 | low | 0 | 0 | 1 | 1 | 1 | 0 |
| 4-hydroxy-2-nonenal | | 4-hydroxynon-2-enal;
4-hydroxynonenal | | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| sphingosine 1-phosphate | | sphingoid 1-phosphate | mouse metabolite;
signalling molecule;
sphingosine-1-phosphate receptor agonist;
T-cell proliferation inhibitor;
vasodilator agent | 2014 | 2020 | 7.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| codeine | | morphinane alkaloid;
organic heteropentacyclic compound | antitussive;
drug allergen;
environmental contaminant;
opioid analgesic;
opioid receptor agonist;
prodrug;
xenobiotic | 1966 | 1980 | 51.4 | low | 0 | 5 | 0 | 0 | 0 | 0 |
| phenylephrine hydrochloride | | hydrochloride | | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 3-amino-1,4-dimethyl-5h-pyrido(4,3-b)indole | | pyridoindole | | 1992 | 1992 | 32.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| nalorphine | | morphinane alkaloid | | 1967 | 1971 | 54.7 | low | 2 | 7 | 0 | 0 | 0 | 0 |
| methylestrenolone | | steroid | estrogen | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| sirolimus | | antibiotic antifungal drug;
cyclic acetal;
cyclic ketone;
ether;
macrolide lactam;
organic heterotricyclic compound;
secondary alcohol | antibacterial drug;
anticoronaviral agent;
antineoplastic agent;
bacterial metabolite;
geroprotector;
immunosuppressive agent;
mTOR inhibitor | 2008 | 2021 | 10.5 | low | 0 | 0 | 0 | 2 | 1 | 1 |
| gamma-cyclodextrin | | cyclodextrin | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| alvocidib | | dihydroxyflavone;
hydroxypiperidine;
monochlorobenzenes;
tertiary amino compound | antineoplastic agent;
antirheumatic drug;
apoptosis inducer;
EC 2.7.11.22 (cyclin-dependent kinase) inhibitor | 2014 | 2018 | 8.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| morphine | | morphinane alkaloid;
organic heteropentacyclic compound;
tertiary amino compound | anaesthetic;
drug allergen;
environmental contaminant;
geroprotector;
mu-opioid receptor agonist;
opioid analgesic;
plant metabolite;
vasodilator agent;
xenobiotic | 1947 | 2006 | 53.2 | low | 1 | 19 | 0 | 2 | 0 | 0 |
| pactamycin | | | | 1977 | 1977 | 47.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| su 5402 | | | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| benzphetamine | | amphetamines;
tertiary amine | adrenergic uptake inhibitor;
appetite depressant;
dopamine uptake inhibitor;
sympathomimetic agent | 1995 | 1995 | 29.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| istradefylline | | oxopurine | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| preclamol | | | | 1985 | 1991 | 37.2 | low | 0 | 4 | 1 | 0 | 0 | 0 |
| lacidipine | | cinnamate ester;
tert-butyl ester | | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| lysophosphatidylcholines | | 1-O-acyl-sn-glycero-3-phosphocholine | | 1996 | 2000 | 26.0 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| cytochalasin b | | cytochalasin;
lactam;
lactone;
organic heterotricyclic compound | actin polymerisation inhibitor;
metabolite;
mycotoxin;
platelet aggregation inhibitor | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 7,7-dimethyl-5,8-eicosadienoic acid | | long-chain fatty acid | | 1997 | 2001 | 25.0 | low | 0 | 0 | 2 | 1 | 0 | 0 |
| 1,2-oleoylphosphatidylcholine | | phosphatidylcholine(1+) | | 2003 | 2014 | 15.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| biliverdine | | | | 2006 | 2009 | 16.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| chrysotoxine | | | | 2020 | 2020 | 4.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 |
| n-cinnamoyltyramine | | cinnamamides;
phenols;
secondary carboxamide | allelochemical;
antimicrobial agent;
phytoalexin;
platelet aggregation inhibitor | 2016 | 2016 | 8.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 |
| tylophorine b | | | | 2000 | 2006 | 20.3 | high | 0 | 0 | 1 | 2 | 0 | 0 |
| dehydroeffusol | | | | 2011 | 2020 | 8.5 | high | 0 | 0 | 0 | 0 | 8 | 0 |
| icariin | | flavonols;
glycosyloxyflavone | antioxidant;
bone density conservation agent;
EC 3.1.4.35 (3',5'-cyclic-GMP phosphodiesterase) inhibitor;
phytoestrogen | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| marchantin c | | | | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| caryophyllene | | | | 1986 | 1986 | 38.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| thebaine | | morphinane alkaloid;
organic heteropentacyclic compound | | 1967 | 1967 | 57.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| mitoguazone | | guanidines;
hydrazone | antineoplastic agent;
apoptosis inducer;
EC 4.1.1.50 (adenosylmethionine decarboxylase) inhibitor | 1985 | 1985 | 39.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| lead | | carbon group element atom;
elemental lead;
metal atom | neurotoxin | 1969 | 2022 | 14.1 | low | 0 | 1 | 0 | 7 | 7 | 2 |
| 4-amylcinnamoylanthranilic acid | | amidobenzoic acid;
cinnamamides;
secondary carboxamide | EC 3.1.1.4 (phospholipase A2) inhibitor;
TRP channel blocker | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| bay 11-7082 | | nitrile;
sulfone | apoptosis inducer;
EC 2.7.11.10 (IkappaB kinase) inhibitor;
EC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitor;
non-steroidal anti-inflammatory drug;
platelet aggregation inhibitor | 2013 | 2019 | 7.3 | low | 0 | 0 | 0 | 0 | 3 | 0 |
| bay 11-7085 | | benzenes;
nitrile;
sulfone | anti-inflammatory agent;
antibacterial agent;
antineoplastic agent;
apoptosis inducer;
autophagy inducer;
EC 2.7.11.10 (IkappaB kinase) inhibitor;
ferroptosis inducer;
NF-kappaB inhibitor | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 15-hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic acid | | | | 1997 | 2006 | 23.3 | low | 0 | 0 | 2 | 1 | 0 | 0 |
| cesium | | alkali metal atom | | 1991 | 1991 | 33.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| aluminum | | boron group element atom;
elemental aluminium;
metal atom | | 1967 | 2023 | 18.4 | low | 0 | 1 | 0 | 1 | 2 | 1 |
| levorphanol | | morphinane alkaloid | | 1970 | 1971 | 53.5 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| bismuth | | metal atom;
pnictogen | | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| levallorphan | | morphinane alkaloid | | 1967 | 1971 | 55.5 | low | 2 | 4 | 0 | 0 | 0 | 0 |
| arsenic | | metalloid atom;
pnictogen | micronutrient | 1964 | 2021 | 15.5 | low | 0 | 2 | 0 | 4 | 12 | 1 |
| indium | | boron group element atom | | 2013 | 2014 | 10.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| dextromethorphan | | 6-methoxy-11-methyl-1,3,4,9,10,10a-hexahydro-2H-10,4a-(epiminoethano)phenanthrene | antitussive;
environmental contaminant;
neurotoxin;
NMDA receptor antagonist;
oneirogen;
prodrug;
xenobiotic | 1997 | 2013 | 19.0 | low | 0 | 0 | 1 | 0 | 1 | 0 |
| gallium | | boron group element atom | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| sulfur | | chalcogen;
nonmetal atom | macronutrient | 1949 | 2017 | 30.8 | low | 0 | 1 | 1 | 2 | 1 | 0 |
| glyceryl behenate | | 1-monoglyceride;
fatty acid ester | antineoplastic agent;
plant metabolite | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| ethyl oleate | | long-chain fatty acid ethyl ester | acaricide;
plant metabolite | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| geldanamycin | | | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| methyl oleate | | fatty acid methyl ester | | 1994 | 1994 | 30.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| diphenylhexatriene | | alkatriene | fluorochrome | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| puerarin | | C-glycosyl compound;
isoflavonoid | | 2016 | 2019 | 6.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| sinomenine | | morphinane alkaloid | | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| ecdysterone | | 14alpha-hydroxy steroid;
20-hydroxy steroid;
22-hydroxy steroid;
25-hydroxy steroid;
2beta-hydroxy steroid;
3beta-sterol;
ecdysteroid;
phytoecdysteroid | animal metabolite;
plant metabolite | 1998 | 1998 | 26.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| deoxyribose | | deoxypentose | human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite | 1992 | 1992 | 32.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| fumarates | | butenedioate;
C4-dicarboxylate | human metabolite;
metabolite;
Saccharomyces cerevisiae metabolite | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| cysteine | | cysteinium | fundamental metabolite | 1965 | 2022 | 28.4 | low | 0 | 4 | 1 | 2 | 3 | 1 |
| silicon | | carbon group element atom;
metalloid atom;
nonmetal atom | | 1971 | 1971 | 53.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| phosphorus | | monoatomic phosphorus;
nonmetal atom;
pnictogen | macronutrient | 1994 | 2022 | 15.1 | low | 0 | 0 | 2 | 3 | 4 | 1 |
| boron | | boron group element atom;
metalloid atom;
nonmetal atom | micronutrient | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| heroin | | morphinane alkaloid | mu-opioid receptor agonist;
opioid analgesic;
prodrug | 1968 | 1969 | 55.5 | low | 1 | 2 | 0 | 0 | 0 | 0 |
| 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid | | | | 2004 | 2006 | 19.0 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| bakuchiol | | | | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| thiosemicarbazone h | | | | 1983 | 1983 | 41.0 | medium | 0 | 1 | 0 | 0 | 0 | 0 |
| triolein | | triglyceride | Caenorhabditis elegans metabolite;
plant metabolite | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| guanabenz | | dichlorobenzene | | 1998 | 1998 | 26.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| carbocyanines | | cyanine dye;
organic iodide salt | fluorochrome | 2018 | 2019 | 5.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| cinidon-ethyl | | ethyl ester;
isoindoles;
monochlorobenzenes | herbicide | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| 1,2-dielaidoylphosphatidylethanolamine | | | | 1997 | 1997 | 27.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| 6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2h-pyran-2-one | | naphthalenes | | 1999 | 2001 | 24.0 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| su 1498 | | enamide;
monocarboxylic acid amide;
nitrile;
phenols;
secondary carboxamide | vascular endothelial growth factor receptor antagonist | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid | | | | 1999 | 1999 | 25.0 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| proguanil | | biguanides;
monochlorobenzenes | antimalarial;
antiprotozoal drug;
EC 1.5.1.3 (dihydrofolate reductase) inhibitor | 1972 | 2020 | 25.6 | low | 1 | 1 | 5 | 4 | 1 | 0 |
| tetrodotoxin | | azatetracycloalkane;
oxatetracycloalkane;
quinazoline alkaloid | animal metabolite;
bacterial metabolite;
marine metabolite;
neurotoxin;
voltage-gated sodium channel blocker | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| selenium | | chalcogen;
nonmetal atom | micronutrient | 1964 | 2018 | 33.0 | low | 0 | 1 | 0 | 0 | 1 | 0 |
| oxalates | | | | 2004 | 2022 | 12.8 | low | 0 | 0 | 0 | 3 | 0 | 1 |
| dizocilpine maleate | | maleate salt;
tetracyclic antidepressant | anaesthetic;
anticonvulsant;
neuroprotective agent;
nicotinic antagonist;
NMDA receptor antagonist | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| antimycin a | | amidobenzoic acid | | 1968 | 1974 | 51.5 | low | 0 | 4 | 0 | 0 | 0 | 0 |
| pregnanediol | | | | 1965 | 1965 | 59.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| longiborneol | | organic molecular entity | | 2006 | 2006 | 18.0 | medium | 0 | 0 | 0 | 1 | 0 | 0 |
| bongkrekic acid | | ether;
olefinic compound;
tricarboxylic acid | apoptosis inhibitor;
ATP/ADP translocase inhibitor;
bacterial metabolite;
EC 2.5.1.18 (glutathione transferase) inhibitor;
toxin | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 1-palmitoyl-2-oleoylphosphatidylcholine | | | | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 1-oleoyl-2-acetylglycerol | | 1,2-diglyceride | | 1992 | 1992 | 32.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| 15-hydroperoxy-5,8,11,13-eicosatetraenoic acid | | HPETE | human xenobiotic metabolite | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| manoalide | | butenolide;
lactol;
sesterterpenoid | EC 3.1.1.4 (phospholipase A2) inhibitor;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
metabolite | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| lumefantrine | | fluorenes;
monochlorobenzenes;
secondary alcohol;
tertiary amine | antimalarial | 2003 | 2020 | 12.6 | low | 0 | 0 | 0 | 3 | 6 | 0 |
| isocupressic acid | | | | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| 2-(4-amylcinnamoyl)amino-4-chlorobenzoic acid | | | | 1993 | 2001 | 27.2 | medium | 0 | 0 | 4 | 1 | 0 | 0 |
| glisoprenin a | | | | 2007 | 2007 | 17.0 | medium | 0 | 0 | 0 | 1 | 0 | 0 |
| valerenic acid | | carbobicyclic compound;
monocarboxylic acid;
sesquiterpenoid | GABA modulator;
plant metabolite;
sedative;
volatile oil component | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| trk 820 | | phenanthrenes | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| chlorophyll | | | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| cgp-56697 | | | | 1999 | 2012 | 18.8 | low | 2 | 0 | 1 | 2 | 1 | 0 |
| salvianolic acid B | | 1-benzofurans;
catechols;
dicarboxylic acid;
enoate ester;
polyphenol | anti-inflammatory agent;
antidepressant;
antineoplastic agent;
antioxidant;
apoptosis inducer;
autophagy inhibitor;
cardioprotective agent;
hepatoprotective agent;
hypoglycemic agent;
neuroprotective agent;
osteogenesis regulator;
plant metabolite | 2005 | 2021 | 12.8 | low | 0 | 0 | 0 | 14 | 11 | 1 |
| verlukast | | | | 2007 | 2017 | 12.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| beta-escin | | | | 1970 | 2022 | 20.8 | low | 0 | 3 | 4 | 5 | 6 | 2 |
| morphinans | | isoquinoline alkaloid fundamental parent;
morphinane alkaloid | | 1969 | 2012 | 29.6 | low | 0 | 2 | 0 | 2 | 1 | 0 |
| ergoline | | diamine;
ergoline alkaloid;
indole alkaloid fundamental parent;
indole alkaloid;
organic heterotetracyclic compound | | 1991 | 1993 | 32.0 | low | 0 | 0 | 3 | 0 | 0 | 0 |
| sq-23377 | | cyclic ether;
enol;
polyunsaturated fatty acid;
very long-chain fatty acid | calcium ionophore;
metabolite | 1993 | 2016 | 19.5 | low | 0 | 0 | 1 | 0 | 1 | 0 |
| fk 866 | | benzamides;
N-acylpiperidine | | 2014 | 2021 | 6.5 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| stepholidine | | | | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| fluorodeoxyglucose f18 | | | | 2002 | 2002 | 22.0 | medium | 0 | 0 | 0 | 1 | 0 | 0 |
| omtriptolide | | | | 2003 | 2020 | 12.0 | high | 0 | 0 | 0 | 1 | 3 | 0 |
| isoborneol | | borneol | | 2017 | 2018 | 6.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| staurosporine | | ammonium ion derivative | | 1993 | 2008 | 22.2 | low | 0 | 0 | 2 | 2 | 0 | 0 |
| bufalin | | 14beta-hydroxy steroid;
3beta-hydroxy steroid | animal metabolite;
anti-inflammatory agent;
antineoplastic agent;
cardiotonic drug | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| phosphocreatine | | phosphagen;
phosphoamino acid | human metabolite;
mouse metabolite | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| pimarane | | diterpene;
terpenoid fundamental parent | | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| formazans | | | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| sincalide | | oligopeptide | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| mocetinostat | | aminopyrimidine;
benzamides;
pyridines;
secondary amino compound;
secondary carboxamide;
substituted aniline | antineoplastic agent;
apoptosis inducer;
autophagy inducer;
cardioprotective agent;
EC 3.5.1.98 (histone deacetylase) inhibitor;
hepatotoxic agent | 2002 | 2020 | 13.5 | low | 0 | 0 | 0 | 10 | 9 | 0 |
| xestospongin a | | | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| gw 4064 | | stilbenoid | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| ginsenoside rb1 | | ginsenoside;
glycoside;
tetracyclic triterpenoid | anti-inflammatory drug;
anti-obesity agent;
apoptosis inhibitor;
neuroprotective agent;
plant metabolite;
radical scavenger | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 2-((aminocarbonyl)amino)-5-(4-fluorophenyl)-3-thiophenecarboxamide | | aromatic amide;
thiophenes | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| tivozanib | | aromatic ether | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| ginsenoside rg3 | | ginsenoside;
glycoside;
tetracyclic triterpenoid | angiogenesis modulating agent;
antineoplastic agent;
apoptosis inducer;
plant metabolite | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| phenylalanyl-glycyl-leucyl-methioninamide | | tetrapeptide | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| zeolites | | | | 2005 | 2024 | 9.4 | low | 0 | 0 | 0 | 1 | 3 | 1 |
| zeolites | | | | 2005 | 2024 | 10.2 | low | 0 | 0 | 0 | 1 | 2 | 1 |
| 3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2h)-isoquinolinone | | | | 2001 | 2014 | 16.2 | medium | 0 | 0 | 0 | 2 | 2 | 0 |
| azonafide | | | | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| 1-oxomiltirone | | | | 2001 | 2017 | 15.0 | high | 0 | 0 | 0 | 1 | 1 | 0 |
| andrastin c | | | | 2013 | 2013 | 11.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 |
| blestriarene c | | | | 2002 | 2015 | 17.3 | high | 0 | 0 | 0 | 2 | 1 | 0 |
| aluminum oxide | | | | 1980 | 2010 | 22.0 | low | 0 | 1 | 0 | 4 | 0 | 0 |
| bisdehydrodoisynolic acid | | | | 1950 | 2010 | 26.8 | high | 0 | 1 | 2 | 5 | 0 | 0 |
| araloside a | | triterpenoid saponin | metabolite | 1991 | 1991 | 33.0 | medium | 0 | 0 | 1 | 0 | 0 | 0 |
| phosphoramidite | | | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| sepantronium | | organic cation | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| artenimol | | | | 1998 | 1999 | 25.5 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| anomalin | | | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| alpha-synuclein | | | | 2007 | 2017 | 12.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| demethylzeylasteral | | arenecarbaldehyde;
benzenediols;
carbopolycyclic compound;
cyclic ketone;
enone;
oxo monocarboxylic acid | anti-inflammatory agent;
EC 2.4.1.17 (glucuronosyltransferase) inhibitor;
immunosuppressive agent;
nephroprotective agent;
plant metabolite | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| artelinic acid | | | | 1993 | 1993 | 31.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| ngr peptide | | | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 1,6-anhydro-beta-d-mannopyranose | | | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| erianthridin | | | | 1997 | 2021 | 14.2 | high | 0 | 0 | 1 | 1 | 2 | 1 |
| denbinobin | | | | 2001 | 2018 | 13.7 | high | 0 | 0 | 0 | 10 | 11 | 0 |
| panepophenanthrin | | | | 2002 | 2010 | 18.5 | high | 0 | 0 | 0 | 6 | 0 | 0 |
| 3,7-dihydroxy-2,4-dimethoxyphenanthrene | | | | 2006 | 2006 | 18.0 | medium | 0 | 0 | 0 | 1 | 0 | 0 |
| oxadiazoles | | | | 2008 | 2013 | 13.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| ly 341495 | | | | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| septicine | | | | 2012 | 2012 | 12.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 |
| decabromodiphenyl ethane | | | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| dioscorealide b | | | | 2006 | 2006 | 18.0 | medium | 0 | 0 | 0 | 1 | 0 | 0 |
| abt-737 | | aromatic amine;
aryl sulfide;
biphenyls;
C-nitro compound;
monochlorobenzenes;
N-arylpiperazine;
N-sulfonylcarboxamide;
secondary amino compound;
tertiary amino compound | anti-allergic agent;
anti-inflammatory agent;
antineoplastic agent;
apoptosis inducer;
B-cell lymphoma 2 inhibitor | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| nu 7441 | | dibenzothiophenes | | 2019 | 2020 | 4.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| cannabidiol hydroxyquinone | | prenylquinone | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Dihydrotanshinone I | | abietane diterpenoid | anticoronaviral agent | 1999 | 2022 | 7.9 | high | 0 | 0 | 2 | 10 | 30 | 18 |
| nutlin-3a | | stilbenoid | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| clematichinenoside ar | | | | 2022 | 2022 | 2.0 | medium | 0 | 0 | 0 | 0 | 0 | 1 |
| dorsomorphin | | aromatic ether;
piperidines;
pyrazolopyrimidine;
pyridines | bone morphogenetic protein receptor antagonist;
EC 2.7.11.31 {[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase} inhibitor | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| artemisone | | | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| quisinostat | | indoles | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| chlorophyll b | | chlorophyll | cofactor | 2019 | 2020 | 4.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| alpha-(2-piperidyl)-3,6-bis(trifluoromethyl)-9-phenanthrenemethanol | | | | 1983 | 2021 | 29.5 | high | 0 | 3 | 2 | 0 | 0 | 1 |
| galactosan | | | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| abexinostat | | benzofurans | | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| losartan potassium | | | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| silvestrol | | dioxanes;
ether;
methyl ester;
organic heterotricyclic compound | antineoplastic agent;
metabolite | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 4-hydroxy-5-azaphenanthrene | | | | 1994 | 1994 | 30.0 | medium | 0 | 0 | 1 | 0 | 0 | 0 |
| pyripyropene a | | organic heterotetracyclic compound;
sesquiterpenoid | acyl-CoA:cholesterol acyltransferase 2 inhibitor;
metabolite | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 7-methoxycryptopleurine | | | | 2007 | 2020 | 11.7 | high | 0 | 0 | 0 | 2 | 1 | 0 |
| calcimycin | | benzoxazole | | 1989 | 2022 | 24.7 | low | 0 | 1 | 5 | 0 | 0 | 1 |
| veliparib | | benzimidazoles | EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor | 2015 | 2017 | 8.0 | low | 0 | 0 | 0 | 0 | 3 | 0 |
| sepharose | | | | 1974 | 2017 | 22.7 | low | 0 | 1 | 0 | 0 | 2 | 0 |
| scopolamine hydrobromide | | | | 2007 | 2016 | 13.0 | low | 0 | 0 | 0 | 2 | 1 | 0 |
| cinobufagin | | steroid lactone | | 1959 | 1959 | 65.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| kobusine | | | | 1962 | 2011 | 31.2 | high | 0 | 1 | 2 | 0 | 1 | 0 |
| pazufloxacin | | | | 1962 | 2011 | 31.9 | high | 0 | 2 | 2 | 1 | 2 | 0 |
| hexacyclinol | | | | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| pituitrin | | | | 1963 | 2009 | 43.0 | low | 0 | 2 | 0 | 1 | 0 | 0 |
| podophyllin | | | | 1972 | 1972 | 52.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| phytosterols | | | | 2000 | 2008 | 20.0 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| doisynolic acid | | | | 1997 | 1997 | 27.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| ouabagenin | | 1-hydroxy steroid;
11alpha-hydroxy steroid;
14beta-hydroxy steroid;
19-hydroxy steroid;
3beta-hydroxy steroid;
5beta-hydroxy steroid | EC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitor | 1993 | 1993 | 31.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| ethidium homodimer-1 | | | | 1953 | 1953 | 71.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| clove | | | | 1985 | 2002 | 32.5 | low | 0 | 2 | 1 | 1 | 0 | 0 |
| acid phosphatase | | | | 1970 | 2015 | 27.0 | low | 0 | 3 | 1 | 1 | 3 | 0 |
| mefloquine | | | | 1982 | 2014 | 27.0 | low | 9 | 12 | 65 | 26 | 5 | 0 |
| bleomycetin | | | | 1994 | 1994 | 30.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| 1,4,5,8,9,12-hexaazatriphenylene | | | | 2012 | 2012 | 12.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 |
| rosmanol | | | | 2001 | 2003 | 21.8 | high | 0 | 0 | 0 | 5 | 0 | 0 |
| salvianolic acid c | | benzofurans | | 2015 | 2019 | 7.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| lyoniside | | | | 1981 | 1981 | 43.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| mogrol | | hydroxy seco-steroid;
tetracyclic triterpenoid | antineoplastic agent | 2022 | 2022 | 2.0 | medium | 0 | 0 | 0 | 0 | 0 | 1 |
| nad | | organophosphate oxoanion | cofactor;
human metabolite;
hydrogen acceptor;
Saccharomyces cerevisiae metabolite | 1965 | 2019 | 20.5 | low | 0 | 3 | 5 | 10 | 9 | 0 |
| cytochrome c-t | | | | 2003 | 2023 | 13.0 | low | 0 | 0 | 0 | 13 | 10 | 1 |
| mf63 compound | | | | 2007 | 2016 | 12.4 | high | 0 | 0 | 0 | 2 | 3 | 0 |
| melitten | | | | 1993 | 2000 | 28.0 | low | 0 | 0 | 8 | 0 | 0 | 0 |
| ceruletide | | oligopeptide | diagnostic agent;
gastrointestinal drug | 1996 | 2022 | 13.2 | low | 0 | 0 | 1 | 1 | 1 | 1 |
| atrial natriuretic factor | | polypeptide | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| glycoprotein e2, hepatitis c virus | | | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| gramicidin a | | | | 1956 | 1956 | 68.0 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| glucagon | | peptide hormone | | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| iberiotoxin | | | | 2008 | 2009 | 15.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| tannins | | | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| oligonucleotides | | | | 1994 | 2019 | 18.9 | low | 0 | 0 | 5 | 7 | 6 | 0 |
| glucagon-like peptide 1 | | | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| cellulose | | glycoside | | 1998 | 2015 | 16.9 | low | 0 | 0 | 1 | 4 | 2 | 0 |
| endothelin-1 | | | | 2002 | 2009 | 17.6 | low | 0 | 0 | 0 | 5 | 0 | 0 |
| phosphatidylcholines | | 1,2-diacyl-sn-glycero-3-phosphocholine | | 1987 | 2020 | 22.0 | low | 0 | 2 | 3 | 4 | 2 | 0 |
| atractyloside | | | | 1973 | 1975 | 50.0 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| chlorophyll a | | chlorophyll;
methyl ester | cofactor | 1967 | 2020 | 12.6 | low | 0 | 1 | 0 | 4 | 14 | 0 |
| thimerosal | | alkylmercury compound | antifungal drug;
antiseptic drug;
disinfectant;
drug allergen | 1998 | 2000 | 25.0 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| hoe 33342 | | | | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| sphingosine kinase | | | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| ubiquinone | | | | 1968 | 2017 | 29.3 | low | 0 | 1 | 1 | 0 | 1 | 0 |
| 1,3,4-oxadiazol-2(3h)-one | | | | 2013 | 2013 | 11.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 |
| calpain | | | | 2017 | 2020 | 5.7 | low | 0 | 0 | 0 | 0 | 3 | 0 |
| miltiradiene | | abietadiene;
carbotricyclic compound | plant metabolite | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| sapogenins | | | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| chitosan | | | | 2002 | 2023 | 7.7 | low | 0 | 0 | 0 | 1 | 3 | 2 |
| nnc 55-0396 | | hydrochloride | angiogenesis inhibitor;
antineoplastic agent;
apoptosis inducer;
neuroprotective agent;
potassium channel blocker;
T-type calcium channel blocker | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 15-deoxyprostaglandin j2 | | | | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| cep 8983 | | | | 2013 | 2013 | 11.0 | high | 0 | 0 | 0 | 0 | 2 | 0 |
| bucladesine | | 3',5'-cyclic purine nucleotide | | 1974 | 2000 | 31.8 | low | 0 | 1 | 3 | 0 | 0 | 0 |
| tert-butoxide, potassium | | | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| tanshinone ii a sodium sulfonate | | | | 1981 | 2023 | 11.2 | high | 5 | 6 | 6 | 20 | 85 | 15 |
| stearates | | | | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| sodium glutamate | | monosodium glutamate | flavouring agent | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| chiniofon | | | | 1984 | 1984 | 40.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| arginine | | | | 1976 | 1976 | 48.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| olaparib | | cyclopropanes;
monofluorobenzenes;
N-acylpiperazine;
phthalazines | antineoplastic agent;
apoptosis inducer;
EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor | 2017 | 2021 | 5.5 | low | 0 | 0 | 0 | 0 | 3 | 1 |
| picrotoxinin | | | | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| methyl jasmonate | | | | 2007 | 2020 | 10.1 | low | 0 | 0 | 0 | 3 | 5 | 0 |
| beta-Elemonic acid | | triterpenoid | | 2020 | 2020 | 4.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 |
| gdc 0449 | | benzamides;
monochlorobenzenes;
pyridines;
sulfone | antineoplastic agent;
Hedgehog signaling pathway inhibitor;
SMO receptor antagonist;
teratogenic agent | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| picrotoxin | | | | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| rosettacin | | | | 2012 | 2012 | 12.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 |
| insulin, isophane | | | | 2006 | 2009 | 16.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| oxymatrine | | | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| niraparib | | 2-[4-(piperidin-3-yl)phenyl]-2H-indazole-7-carboxamide | antineoplastic agent;
apoptosis inducer;
EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor;
radiosensitizing agent | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| mk 2206 | | organic heterotricyclic compound | EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| navitoclax | | aryl sulfide;
monochlorobenzenes;
morpholines;
N-sulfonylcarboxamide;
organofluorine compound;
piperazines;
secondary amino compound;
sulfone;
tertiary amino compound | antineoplastic agent;
apoptosis inducer;
B-cell lymphoma 2 inhibitor | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| pervanadate | | | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene | | BODIPY compound | | 2008 | 2021 | 8.7 | low | 0 | 0 | 0 | 1 | 1 | 1 |
| cardiovascular agents | | | | 1981 | 2021 | 24.7 | low | 3 | 5 | 5 | 6 | 1 | 2 |
| neurotensin | | peptide hormone | human metabolite;
mitogen;
neurotransmitter;
vulnerary | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| mannans | | | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| gsk 2126458 | | aromatic ether;
difluorobenzene;
pyridazines;
pyridines;
quinolines;
sulfonamide | anticoronaviral agent;
antineoplastic agent;
autophagy inducer;
EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor;
mTOR inhibitor;
radiosensitizing agent | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| ixazomib | | benzamides;
boronic acids;
dichlorobenzene;
glycine derivative | antineoplastic agent;
apoptosis inducer;
drug metabolite;
orphan drug;
proteasome inhibitor | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| kurarinone | | | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| peptones | | | | 2008 | 2023 | 10.2 | low | 0 | 0 | 0 | 1 | 2 | 1 |
| glycolipids | | | | 2001 | 2022 | 11.1 | low | 0 | 0 | 0 | 8 | 17 | 2 |
| piperidines | | | | 1972 | 2021 | 29.2 | low | 0 | 16 | 1 | 3 | 10 | 1 |
| manassantin a | | | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| interleukin-8 | | | | 1999 | 2021 | 15.2 | low | 0 | 0 | 2 | 10 | 5 | 1 |
| sofosbuvir | | isopropyl ester;
L-alanyl ester;
nucleotide conjugate;
organofluorine compound;
phosphoramidate ester | antiviral drug;
hepatitis C protease inhibitor;
prodrug | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| bufadienolide | | bufadienolides | | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 14-o-phosphonooxymethyltriptolide | | | | 2012 | 2023 | 8.3 | high | 0 | 0 | 0 | 0 | 26 | 2 |
| dinaciclib | | pyrazolopyrimidine | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| abt-199 | | aromatic ether;
C-nitro compound;
monochlorobenzenes;
N-alkylpiperazine;
N-arylpiperazine;
N-sulfonylcarboxamide;
oxanes;
pyrrolopyridine | antineoplastic agent;
apoptosis inducer;
B-cell lymphoma 2 inhibitor | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| methylcellulose | | | | 1972 | 2007 | 30.3 | low | 0 | 1 | 0 | 2 | 0 | 0 |
| heme | | | | 1988 | 1999 | 30.5 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| chondroitin | | | | 1966 | 1966 | 58.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| 2,3-dihydro-2,5-dihydroxy-4h-benzopyran-4-one | | | | 2012 | 2012 | 12.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 |
| ascorbic acid | | ascorbic acid;
vitamin C | coenzyme;
cofactor;
flour treatment agent;
food antioxidant;
food colour retention agent;
geroprotector;
plant metabolite;
skin lightening agent | 1964 | 2022 | 25.1 | low | 0 | 4 | 3 | 4 | 5 | 1 |
| tetracycline | | | | 1973 | 2004 | 36.0 | low | 2 | 2 | 2 | 1 | 0 | 0 |
| oxytetracycline, anhydrous | | | | 1974 | 2017 | 28.5 | low | 0 | 1 | 0 | 0 | 1 | 0 |
| minocycline | | | | 2010 | 2021 | 10.0 | low | 0 | 0 | 0 | 1 | 1 | 1 |
| salicylates | | monohydroxybenzoate | plant metabolite | 1974 | 2021 | 22.2 | low | 0 | 2 | 0 | 6 | 1 | 1 |
| dicumarol | | hydroxycoumarin | anticoagulant;
EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitor;
Hsp90 inhibitor;
vitamin K antagonist | 1994 | 2016 | 20.2 | low | 0 | 0 | 2 | 3 | 1 | 0 |
| laquinimod | | aromatic amide | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| warfarin | | benzenes;
hydroxycoumarin;
methyl ketone | | 1962 | 2020 | 25.6 | low | 0 | 3 | 3 | 5 | 4 | 0 |
| metastat | | | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| teriflunomide | | (trifluoromethyl)benzenes;
aromatic amide;
enamide;
enol;
nitrile;
secondary carboxamide | drug metabolite;
EC 1.3.98.1 [dihydroorotate oxidase (fumarate)] inhibitor;
hepatotoxic agent;
non-steroidal anti-inflammatory drug;
tyrosine kinase inhibitor | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| mna 715 | | | | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| epidermal growth factor | | | | 2009 | 2011 | 14.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| kaolinite | | aluminosilicate mineral;
mixture | antidiarrhoeal drug;
excipient | 2001 | 2023 | 13.4 | low | 0 | 0 | 0 | 9 | 4 | 1 |
| clay | | | | 1998 | 2022 | 14.7 | low | 0 | 0 | 1 | 18 | 8 | 2 |
| charybdotoxin | | | | 2011 | 2015 | 11.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| lead radioisotopes | | | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| transforming growth factor beta | | | | 1999 | 2020 | 13.7 | low | 0 | 0 | 2 | 2 | 7 | 0 |
| phytoestrogens | | | | 2000 | 2018 | 14.0 | low | 0 | 0 | 1 | 1 | 2 | 0 |
| okadaic acid | | ketal | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| pyrethrins | | | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| stemofoline | | | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| agar | | | | 2006 | 2008 | 17.0 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| cyclin d1 | | | | 2005 | 2020 | 11.5 | low | 0 | 0 | 0 | 5 | 6 | 0 |
| contraceptives, postcoital | | | | 1974 | 1974 | 50.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| oligomycins | | | | 1973 | 1974 | 50.4 | low | 0 | 9 | 0 | 0 | 0 | 0 |
| illite | | | | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| asbestos, crocidolite | | | | 1986 | 1986 | 38.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| phthalocyanine | | phthalocyanines;
tetrapyrrole fundamental parent | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone | | | | 2005 | 2019 | 12.4 | low | 0 | 0 | 0 | 3 | 4 | 0 |
| nitrophenols | | | | 1965 | 2021 | 28.8 | low | 0 | 3 | 0 | 1 | 1 | 1 |
| bassianolide | | cyclodepsipeptide;
cyclooctadepsipeptide | antineoplastic agent;
fungal metabolite;
insecticide | 2002 | 2016 | 11.8 | low | 0 | 0 | 0 | 1 | 3 | 0 |
| glaucarubin | | | | 1980 | 1989 | 40.6 | high | 0 | 35 | 0 | 0 | 0 | 0 |
| hyaluronoglucosaminidase | | | | 1995 | 1995 | 29.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| nephrin | | | | 2008 | 2020 | 10.7 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| carboxyatractyloside | | | | 1973 | 1973 | 51.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| ginkgolide b | | | | 1997 | 1997 | 27.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| oridonin | | | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| ailanthone | | | | 1981 | 1981 | 43.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| morroniside | | | | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| gibberellins | | | | 2006 | 2019 | 9.5 | low | 0 | 0 | 0 | 1 | 3 | 0 |
| sorbicillinol | | | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| trichodermin | | | | 1977 | 1978 | 46.5 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| nifedipine | | | | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| peoniflorin | | | | 2008 | 2019 | 9.5 | low | 0 | 0 | 0 | 1 | 3 | 0 |
| vitamin b 12 | | | | 2001 | 2015 | 16.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| aconitine | | | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| s 8932 | | aromatic amine;
C-nucleoside;
carboxylic ester;
nitrile;
phosphoramidate ester;
pyrrolotriazine | anticoronaviral agent;
antiviral drug;
prodrug | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| transforming growth factor alpha | | | | 1997 | 2001 | 25.0 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| as 1411 | | | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| wilforgine | | acetate ester;
dihydroagarofuran sesquiterpenoid;
furans;
macrocyclic lactone;
organic heteropentacyclic compound;
pyridine alkaloid | plant metabolite | 2008 | 2017 | 11.0 | high | 0 | 0 | 0 | 1 | 2 | 0 |
| cyclosporine | | | | 1998 | 2014 | 20.1 | low | 0 | 0 | 7 | 5 | 3 | 0 |
| silybin | | | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| digitonin | | | | 1974 | 1974 | 50.0 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| catalpol | | | | 2019 | 2020 | 4.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| jarosite | | | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| sparsomycin | | | | 1977 | 1977 | 47.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| phenanthroindolizidine | | | | 2006 | 2016 | 11.2 | high | 0 | 0 | 0 | 2 | 10 | 0 |
| phenanthroquinolizidine | | | | 2006 | 2014 | 14.0 | high | 0 | 0 | 0 | 2 | 1 | 0 |
| orabase | | | | 2013 | 2022 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 2 |
| thromboplastin | | | | 2001 | 2021 | 13.4 | low | 0 | 0 | 0 | 3 | 1 | 1 |
| muramidase | | | | 1969 | 2017 | 27.7 | low | 0 | 2 | 0 | 3 | 1 | 0 |
| amyloid beta-peptides | | | | 2004 | 2014 | 13.8 | low | 0 | 0 | 0 | 1 | 3 | 0 |
| chondroitin sulfates | | | | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| nu 1025 | | phenols;
quinazolines | EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor | 2004 | 2005 | 19.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| cyclic gmp | | 3',5'-cyclic purine nucleotide;
guanyl ribonucleotide | Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite | 1993 | 2017 | 18.0 | low | 0 | 0 | 1 | 1 | 1 | 0 |
| deoxyguanosine | | purine 2'-deoxyribonucleoside;
purines 2'-deoxy-D-ribonucleoside | Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite | 1987 | 2004 | 29.6 | low | 0 | 3 | 7 | 2 | 0 | 0 |
| deoxyinosine | | purine 2'-deoxyribonucleoside;
purines 2'-deoxy-D-ribonucleoside | Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite | 1987 | 1987 | 37.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| 2'-deoxyguanosine 5'-phosphate | | deoxyguanosine phosphate;
guanyl deoxyribonucleotide;
purine 2'-deoxyribonucleoside 5'-monophosphate | Escherichia coli metabolite;
mouse metabolite | 1994 | 1994 | 30.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| guanosine monophosphate | | guanosine 5'-phosphate;
purine ribonucleoside 5'-monophosphate | biomarker;
Escherichia coli metabolite;
metabolite;
mouse metabolite | 1994 | 2015 | 19.5 | low | 0 | 0 | 1 | 0 | 1 | 0 |
| guanosine triphosphate | | guanosine 5'-phosphate;
purine ribonucleoside 5'-triphosphate | Escherichia coli metabolite;
mouse metabolite;
uncoupling protein inhibitor | 1976 | 2011 | 35.7 | low | 0 | 2 | 0 | 0 | 1 | 0 |
| guanine | | 2-aminopurines;
oxopurine;
purine nucleobase | algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite | 1975 | 2019 | 24.0 | low | 0 | 2 | 3 | 1 | 3 | 0 |
| guanosine | | guanosines;
purines D-ribonucleoside | fundamental metabolite | 1973 | 1992 | 43.4 | low | 0 | 4 | 1 | 0 | 0 | 0 |
| hypoxanthine | | nucleobase analogue;
oxopurine;
purine nucleobase | fundamental metabolite | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| inosine | | inosines;
purines D-ribonucleoside | Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite | 1977 | 2008 | 33.3 | low | 0 | 2 | 0 | 1 | 0 | 0 |
| folic acid | | folic acids;
N-acyl-amino acid | human metabolite;
mouse metabolite;
nutrient | 2001 | 2022 | 8.2 | low | 0 | 0 | 0 | 1 | 2 | 3 |
| 3-methyladenine | | | | 2013 | 2018 | 8.0 | low | 0 | 0 | 0 | 0 | 3 | 0 |
| guanosine 5'-o-(3-thiotriphosphate) | | nucleoside triphosphate analogue | | 1994 | 1994 | 30.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| pheophytin a | | | | 2014 | 2020 | 6.0 | low | 0 | 0 | 0 | 0 | 4 | 0 |
| neopterin | | | | 1997 | 1997 | 27.0 | low | 1 | 0 | 1 | 0 | 0 | 0 |
| clozapine | | benzodiazepine;
N-arylpiperazine;
N-methylpiperazine;
organochlorine compound | adrenergic antagonist;
dopaminergic antagonist;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
environmental contaminant;
GABA antagonist;
histamine antagonist;
muscarinic antagonist;
second generation antipsychotic;
serotonergic antagonist;
xenobiotic | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| dacarbazine | | dacarbazine | | 2014 | 2017 | 8.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| ganciclovir | | 2-aminopurines;
oxopurine | antiinfective agent;
antiviral drug | 2001 | 2004 | 21.3 | low | 0 | 0 | 0 | 3 | 0 | 0 |
| allopurinol | | nucleobase analogue;
organic heterobicyclic compound | antimetabolite;
EC 1.17.3.2 (xanthine oxidase) inhibitor;
gout suppressant;
radical scavenger | 1990 | 2009 | 24.3 | low | 0 | 0 | 3 | 4 | 0 | 0 |
| valganciclovir | | L-valyl ester;
purines | antiviral drug;
prodrug | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| xav939 | | (trifluoromethyl)benzenes;
thiopyranopyrimidine | tankyrase inhibitor | 2012 | 2020 | 8.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| trypan blue | | | | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| methylnitronitrosoguanidine | | nitroso compound | alkylating agent | 1977 | 2010 | 31.1 | low | 0 | 4 | 0 | 3 | 0 | 0 |
| 8-hydroxy-2'-deoxyguanosine | | guanosines | biomarker | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| n-(deoxyguanosin-8-yl)acetylaminofluorene | | guanosines | | 1990 | 1990 | 34.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| 2-naphthol orange | | | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| remazol black b | | | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| prodigiosin | | | | 1976 | 1976 | 48.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| n-(deoxyguanosin-8-yl)-2-aminofluorene | | guanosines | | 1990 | 1990 | 34.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| bmn 673 | | | | 2017 | 2021 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| cyanine dye 3 | | | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| cholestyramine resin | | | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| eye | | | | 1980 | 2007 | 30.5 | low | 0 | 1 | 0 | 1 | 0 | 0 |
| acetylcellulose | | | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| ferroquine | | | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| wilforine | | | | 2008 | 2017 | 11.2 | high | 0 | 0 | 0 | 1 | 3 | 0 |
| pseudolaric acid b | | | | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| mordenite | | | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| concanavalin a | | | | 1994 | 2010 | 20.8 | low | 0 | 0 | 2 | 3 | 0 | 0 |
| chlorotoxin | | | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| nk314 | | | | 2007 | 2020 | 12.0 | high | 0 | 0 | 0 | 3 | 4 | 0 |
| dinitrobenzenes | | | | 2007 | 2017 | 11.3 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| phosphorus radioisotopes | | | | 1974 | 2001 | 34.9 | low | 0 | 6 | 6 | 2 | 0 | 0 |
| leptin | | | | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| pyrimidinones | | | | 1970 | 1970 | 54.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Condition | Indicated | Studies | First Year | Last Year | Average Age | Relationship Strength | Trials | pre-1990 | 1990's | 2000's | 2010's | post-2020 |
|---|
| 2019 Novel Coronavirus Disease | 0 | | 2020 | 2021 | 3.5 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| A-V Dissociation | 0 | | 1993 | 2017 | 20.7 | low | 0 | 0 | 2 | 0 | 1 | 0 |
| Abdominal Migraine | 0 | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Abnormalities, Autosome | 0 | | 1973 | 2019 | 36.5 | low | 0 | 7 | 1 | 2 | 1 | 0 |
| Abnormalities, Cardiovascular | 0 | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Abnormalities, Drug-Induced | 0 | | 1967 | 2013 | 28.7 | low | 0 | 1 | 0 | 1 | 1 | 0 |
| Abscess | 0 | | 1966 | 1966 | 58.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Abscess, Amebic | 0 | | 1956 | 1959 | 66.1 | low | 0 | 17 | 0 | 0 | 0 | 0 |
| Abscess, Pulmonary | 0 | | 1962 | 1962 | 62.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Absence Seizure | 0 | | 1969 | 1974 | 52.3 | low | 1 | 3 | 0 | 0 | 0 | 0 |
| Absence Status | 0 | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Academic Disorder, Developmental | 0 | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Ache | 0 | | 2001 | 2016 | 13.8 | low | 0 | 0 | 0 | 3 | 3 | 0 |
| Acid Aspiration Syndrome | 0 | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Acne | 0 | | 1980 | 2022 | 23.8 | low | 0 | 3 | 0 | 0 | 2 | 1 |
| Acne Vulgaris | 0 | | 1980 | 2022 | 23.8 | low | 0 | 3 | 0 | 0 | 2 | 1 |
| Acquired Immune Deficiency Syndrome | 0 | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Acquired Immunodeficiency Syndrome | 0 | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Actinic Reticuloid Syndrome | 0 | | 1972 | 1973 | 51.5 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| Acute Brain Injuries | 0 | | 2005 | 2016 | 12.0 | low | 0 | 0 | 0 | 2 | 4 | 0 |
| Acute Confusional Senile Dementia | 0 | | 2002 | 2022 | 9.6 | low | 0 | 0 | 0 | 6 | 17 | 4 |
| Acute Coronary Syndrome | 0 | | 2015 | 2021 | 6.0 | low | 1 | 0 | 0 | 0 | 1 | 1 |
| Acute Disease | 0 | | 1974 | 2022 | 25.8 | low | 9 | 1 | 18 | 4 | 4 | 1 |
| Acute Edematous Pancreatitis | 0 | | 2005 | 2022 | 12.8 | low | 0 | 0 | 0 | 3 | 1 | 1 |
| Acute Hepatic Failure | 0 | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Acute Hypercapnic Respiratory Failure | 0 | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Acute Ischemic Stroke | 0 | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Acute Kidney Failure | 0 | | 1999 | 2019 | 14.3 | low | 0 | 0 | 2 | 3 | 6 | 0 |
| Acute Kidney Injury | 0 | | 1999 | 2019 | 14.3 | low | 0 | 0 | 2 | 3 | 6 | 0 |
| Acute Kidney Tubular Necrosis | 0 | | 1974 | 2002 | 31.7 | low | 0 | 1 | 0 | 2 | 0 | 0 |
| Acute Liver Injury, Drug-Induced | 0 | | 1984 | 2023 | 8.4 | low | 0 | 2 | 1 | 5 | 40 | 9 |
| Acute Lung Injury | 0 | | 2009 | 2022 | 9.8 | low | 0 | 0 | 0 | 1 | 7 | 1 |
| Acute Lymphoid Leukemia | 0 | | 2004 | 2016 | 12.0 | low | 0 | 0 | 0 | 2 | 6 | 0 |
| Acute Myelogenous Leukemia | 0 | | 2007 | 2022 | 8.8 | low | 0 | 0 | 0 | 3 | 8 | 2 |
| Acute Onset Vascular Dementia | 0 | | 2010 | 2019 | 8.0 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| Acute Pain | 0 | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Acute Promyelocytic Leukemia | 0 | | 1991 | 2017 | 18.5 | low | 0 | 0 | 3 | 11 | 1 | 0 |
| Acute Respiratory Distress Syndrome | 0 | | 1994 | 2021 | 16.5 | low | 0 | 0 | 1 | 0 | 0 | 1 |
| Addiction, Opioid | 0 | | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Addison Disease | 0 | | 1970 | 1970 | 54.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Addison's Disease | 0 | | 1970 | 1970 | 54.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Adenocarcinoma | 0 | | 1964 | 2021 | 14.8 | low | 0 | 2 | 1 | 9 | 16 | 1 |
| Adenocarcinoma Of Kidney | 0 | | 2011 | 2017 | 9.7 | low | 0 | 0 | 0 | 0 | 3 | 0 |
| Adenocarcinoma of Lung | 0 | | 2012 | 2020 | 8.3 | low | 0 | 0 | 0 | 0 | 6 | 0 |
| Adenocarcinoma, Basal Cell | 0 | | 1964 | 2021 | 14.8 | low | 0 | 2 | 1 | 9 | 16 | 1 |
| Adenoma | 0 | | 1979 | 2018 | 28.2 | low | 0 | 3 | 1 | 1 | 1 | 0 |
| Adenoma, Basal Cell | 0 | | 1979 | 2018 | 28.2 | low | 0 | 3 | 1 | 1 | 1 | 0 |
| Adenoma, Prostatic | 0 | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Adhesions, Tissue | 0 | | 2012 | 2019 | 8.3 | low | 0 | 0 | 0 | 0 | 3 | 0 |
| Adjuvant Arthritis | 0 | | 1980 | 2021 | 13.5 | low | 0 | 2 | 1 | 12 | 17 | 3 |
| Adolescent Gynecomastia | 0 | | 1973 | 1973 | 51.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| ADPKD | 0 | | 2008 | 2021 | 10.8 | low | 0 | 0 | 0 | 2 | 1 | 1 |
| Adrenal Cancer | 0 | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Adult Fanconi Syndrome | 0 | | 1997 | 2002 | 23.8 | low | 0 | 0 | 3 | 3 | 0 | 0 |
| Adult Spinal Muscular Atrophy | 0 | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Adverse Drug Event | 0 | | 1973 | 2023 | 10.6 | low | 0 | 1 | 0 | 0 | 2 | 4 |
| African Lymphoma | 0 | | 2001 | 2018 | 13.7 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| African Sleeping Sickness | 0 | | 1954 | 1954 | 70.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Age-Related Memory Disorders | 0 | | 2007 | 2016 | 13.0 | low | 0 | 0 | 0 | 3 | 2 | 0 |
| Age-Related Osteoporosis | 0 | | 2010 | 2020 | 8.5 | low | 0 | 0 | 0 | 1 | 3 | 0 |
| Aggression | 0 | | 1967 | 1967 | 57.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Aging | 0 | | 2002 | 2018 | 11.8 | low | 0 | 0 | 0 | 3 | 5 | 0 |
| Agnogenic Myeloid Metaplasia | 0 | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| AIDS-Related Opportunistic Infections | 0 | | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Airflow Obstruction, Chronic | 0 | | 2018 | 2020 | 5.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Airway Hyper-Responsiveness | 0 | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Airway Remodeling | 0 | | 2007 | 2020 | 11.0 | low | 0 | 0 | 0 | 2 | 4 | 0 |
| Albuminuria | 0 | | 2012 | 2018 | 9.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Alcohol Abuse | 0 | | 1966 | 1966 | 58.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Alcohol Drinking | 0 | | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Alcoholic Fatty Liver | 0 | | 2017 | 2018 | 6.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Alcoholic Liver Diseases | 0 | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Alcoholism | 0 | | 1966 | 1966 | 58.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Aldosteronism | 0 | | 1970 | 1970 | 54.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Allergic Contact Dermatitis | 0 | | 1993 | 2005 | 26.6 | low | 0 | 0 | 7 | 2 | 0 | 0 |
| Allergic Encephalomyelitis | 0 | | 2002 | 2015 | 15.9 | low | 0 | 0 | 0 | 7 | 2 | 0 |
| Allergic Reaction | 0 | | 1965 | 2020 | 25.7 | low | 0 | 1 | 0 | 1 | 1 | 0 |
| Allergy, Drug | 0 | | 1973 | 2008 | 40.6 | low | 1 | 5 | 1 | 1 | 0 | 0 |
| Allodynia | 0 | | 2007 | 2021 | 11.4 | low | 0 | 0 | 0 | 3 | 3 | 1 |
| Alloxan Diabetes | 0 | | 1975 | 2023 | 13.1 | low | 0 | 1 | 0 | 11 | 13 | 2 |
| Alveolar Bone Atrophy | 0 | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Alveolitis, Fibrosing | 0 | | 1994 | 2022 | 9.3 | low | 0 | 0 | 1 | 1 | 7 | 1 |
| Alzheimer Disease | 0 | | 2002 | 2022 | 9.6 | low | 0 | 0 | 0 | 6 | 17 | 4 |
| Amebiasis | 0 | | 1956 | 1959 | 66.1 | low | 0 | 17 | 0 | 0 | 0 | 0 |
| Amebiasis, Intestinal | 0 | | 1956 | 1969 | 65.4 | low | 0 | 16 | 0 | 0 | 0 | 0 |
| Amnesia | 0 | | 1994 | 2010 | 22.0 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| Amnesia-Memory Loss | 0 | | 1994 | 2010 | 22.0 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| Amyloid Deposits | 0 | | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Amyloidosis | 0 | | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Anaphylactic Reaction | 0 | | 1980 | 1997 | 35.5 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| Anaphylaxis | 0 | | 1980 | 1997 | 35.5 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| Anaplasia | 0 | | 1977 | 1977 | 47.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Anasarca | 0 | | 1970 | 2020 | 21.3 | low | 0 | 5 | 4 | 8 | 8 | 0 |
| Androgen-Independent Prostatic Cancer | 0 | | 2014 | 2017 | 8.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Androgenization | 0 | | 1970 | 1970 | 54.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Anemia | 0 | | 1967 | 2019 | 25.7 | low | 1 | 1 | 0 | 1 | 1 | 0 |
| Anesthesia | 0 | | 1970 | 1996 | 41.0 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| Angina at Rest | 0 | | 2009 | 2023 | 7.3 | low | 1 | 0 | 0 | 1 | 1 | 1 |
| Angina Pectoris | 0 | | 1981 | 2023 | 16.0 | low | 0 | 1 | 0 | 1 | 0 | 2 |
| Angina, Unstable | 0 | | 2009 | 2023 | 7.3 | low | 1 | 0 | 0 | 1 | 1 | 1 |
| Angiogenesis, Pathologic | 0 | | 2000 | 2022 | 10.0 | low | 0 | 0 | 1 | 3 | 17 | 1 |
| Angioma | 0 | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Angiospasm, Intracranial | 0 | | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Angor Pectoris | 0 | | 1981 | 2023 | 16.0 | low | 0 | 1 | 0 | 1 | 0 | 2 |
| Animal Diseases | 0 | | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Animal Mammary Carcinoma | 0 | | 1963 | 1964 | 60.5 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| Ankylosing Spondylarthritis | 0 | | 2018 | 2022 | 4.3 | low | 0 | 0 | 0 | 0 | 2 | 1 |
| Anochlesia | 0 | | 1978 | 1978 | 46.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Anoxemia | 0 | | 1990 | 2022 | 14.2 | low | 0 | 0 | 2 | 4 | 5 | 1 |
| Anoxia-Ischemia, Brain | 0 | | 2005 | 2007 | 18.0 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| Anterior Cerebral Circulation Infarction | 0 | | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Anterior Choroidal Artery Infarction | 0 | | 2006 | 2009 | 16.3 | low | 0 | 0 | 0 | 3 | 0 | 0 |
| Anterior Circulation Transient Ischemic Attack | 0 | | 2006 | 2021 | 12.8 | low | 0 | 0 | 0 | 3 | 0 | 1 |
| Anxiety | 0 | | 2014 | 2016 | 9.3 | low | 0 | 0 | 0 | 0 | 3 | 0 |
| Aortic Stenosis | 0 | | 2011 | 2021 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| Aortic Valve Stenosis | 0 | | 2011 | 2021 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| Apoplexy | 0 | | 2001 | 2022 | 11.3 | low | 1 | 0 | 0 | 6 | 7 | 2 |
| Appendicitis | 0 | | 1993 | 1994 | 30.5 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| Arachnoidal Cerebellar Sarcoma, Circumscribed | 0 | | 2016 | 2018 | 7.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Arrhythmia | 0 | | 1963 | 2023 | 26.0 | low | 0 | 4 | 6 | 5 | 2 | 2 |
| Arrhythmias, Cardiac | 0 | | 1963 | 2023 | 26.0 | low | 0 | 4 | 6 | 5 | 2 | 2 |
| Arsenic Encephalopathy | 0 | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Arterial Obstructive Diseases | 0 | | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Arterial Occlusive Diseases | 0 | | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Arteriosclerosis, Coronary | 0 | | 1999 | 2017 | 16.3 | low | 1 | 0 | 1 | 1 | 1 | 0 |
| Arthritis | 0 | | 1964 | 2021 | 26.6 | low | 0 | 2 | 0 | 3 | 1 | 1 |
| Arthritis, Degenerative | 0 | | 2010 | 2021 | 7.1 | low | 0 | 0 | 0 | 1 | 4 | 2 |
| Arthritis, Rheumatoid | 0 | | 1969 | 2022 | 11.4 | low | 6 | 1 | 6 | 13 | 27 | 11 |
| Ascites | 0 | | 1960 | 1967 | 61.0 | low | 0 | 3 | 0 | 0 | 0 | 0 |
| Asthma | 0 | | 1980 | 2023 | 19.0 | low | 1 | 2 | 4 | 8 | 6 | 1 |
| Asthma, Bronchial | 0 | | 1980 | 2023 | 19.0 | low | 1 | 2 | 4 | 8 | 6 | 1 |
| Astrocytoma, Grade IV | 0 | | 2007 | 2021 | 7.9 | low | 0 | 0 | 0 | 1 | 7 | 2 |
| Astrocytosis | 0 | | 2008 | 2014 | 13.3 | low | 0 | 0 | 0 | 2 | 1 | 0 |
| Asymmetric Diabetic Proximal Motor Neuropathy | 0 | | 2004 | 2010 | 17.0 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| Asystole | 0 | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| At-V1 | 0 | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 2 |
| Ataxia | 0 | | 1993 | 1993 | 31.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Ataxia Telangiectasia | 0 | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Ataxia Telangiectasia Syndrome | 0 | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Atherogenesis | 0 | | 2005 | 2022 | 10.7 | low | 0 | 0 | 0 | 4 | 9 | 1 |
| Atheroma | 0 | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Atherosclerosis | 0 | | 2005 | 2022 | 10.7 | low | 0 | 0 | 0 | 4 | 9 | 1 |
| Atherosclerotic Parkinsonism | 0 | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| ATLL | 0 | | 1999 | 2015 | 17.0 | low | 0 | 0 | 1 | 0 | 1 | 0 |
| Atrial Fibrillation | 0 | | 2018 | 2023 | 4.3 | low | 0 | 0 | 0 | 0 | 2 | 1 |
| Atrioventricular Block | 0 | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Atrioventricular Conduction Block | 0 | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Atrioventricular Nodal Re-Entrant Tachycardia | 0 | | 1994 | 2001 | 26.5 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| Atrophy | 0 | | 1967 | 2002 | 39.5 | low | 0 | 1 | 0 | 1 | 0 | 0 |
| Atrophy, Muscle | 0 | | 2017 | 2020 | 5.0 | low | 0 | 0 | 0 | 0 | 3 | 0 |
| Atypical Lipomatous Tumor | 0 | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Atypical Mycobacterial Infection, Disseminated | 0 | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Aura | 0 | | 1991 | 2018 | 16.3 | low | 0 | 0 | 1 | 0 | 2 | 0 |
| Auricular Fibrillation | 0 | | 2018 | 2023 | 4.3 | low | 0 | 0 | 0 | 0 | 2 | 1 |
| Autism | 0 | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Autistic Disorder | 0 | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Autoimmune Diabetes | 0 | | 2003 | 2013 | 16.3 | low | 0 | 0 | 0 | 2 | 1 | 0 |
| Autoimmune Disease | 0 | | 2003 | 2021 | 11.2 | low | 0 | 0 | 0 | 1 | 3 | 1 |
| Autoimmune Diseases | 0 | | 2003 | 2021 | 11.2 | low | 0 | 0 | 0 | 1 | 3 | 1 |
| Autosomal Dominant Juvenile Parkinson Disease | 0 | | 2006 | 2012 | 15.3 | low | 0 | 0 | 0 | 2 | 1 | 0 |
| Autosomal Hemophilia A | 0 | | 1959 | 1959 | 65.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Avian Diseases | 0 | | 1981 | 1981 | 43.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| B-Cell Chronic Lymphocytic Leukemia | 0 | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| B-Cell Lymphoma | 0 | | 2006 | 2015 | 15.0 | low | 0 | 0 | 0 | 2 | 1 | 0 |
| B16 Melanoma | 0 | | 2003 | 2016 | 14.0 | low | 0 | 0 | 0 | 2 | 3 | 0 |
| Bacterial Disease | 0 | | 1990 | 2002 | 28.0 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| Bacterial Endocarditides | 0 | | 1966 | 1966 | 58.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Bacterial Infections | 0 | | 1990 | 2002 | 28.0 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| Bacterial Meningitides | 0 | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Bacterial Pneumonia | 0 | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Balkan Endemic Nephropathy | 0 | | 1999 | 2006 | 22.0 | low | 0 | 0 | 1 | 3 | 0 | 0 |
| Bed Sores | 0 | | 1964 | 1964 | 60.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Behavior Disorders | 0 | | 2007 | 2016 | 13.2 | low | 0 | 0 | 0 | 2 | 2 | 0 |
| Benign Cerebellar Neoplasms | 0 | | 2016 | 2018 | 7.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Benign Neoplasms | 0 | | 1946 | 2023 | 19.4 | low | 1 | 19 | 1 | 21 | 47 | 8 |
| Benign Neoplasms, Brain | 0 | | 2007 | 2020 | 9.2 | low | 0 | 0 | 0 | 2 | 10 | 0 |
| Berger Disease | 0 | | 2015 | 2022 | 5.8 | low | 0 | 0 | 0 | 0 | 3 | 1 |
| Besnier-Boeck Disease | 0 | | 1970 | 1970 | 54.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Bilateral Headache | 0 | | 1973 | 1973 | 51.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Bilateral Wilms Tumor | 0 | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Bile Duct Cancer | 0 | | 1998 | 2017 | 18.2 | low | 0 | 0 | 1 | 3 | 1 | 0 |
| Bile Duct Neoplasms | 0 | | 1998 | 2017 | 18.2 | low | 0 | 0 | 1 | 3 | 1 | 0 |
| Bile Duct Obstruction | 0 | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Bilharziasis | 0 | | 2013 | 2014 | 10.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Black Water Fever | 0 | | 1992 | 2002 | 27.0 | low | 0 | 0 | 3 | 1 | 0 | 0 |
| Bladder Cancer | 0 | | 1972 | 2021 | 18.1 | low | 0 | 1 | 1 | 2 | 3 | 1 |
| Bladder Neck Obstruction | 0 | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Blast Crisis | 0 | | 2009 | 2020 | 10.3 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| Blast Phase | 0 | | 2009 | 2020 | 10.3 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| Bleeding | 0 | | 2013 | 2018 | 8.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Blood Clot | 0 | | 1984 | 2018 | 20.3 | low | 0 | 1 | 0 | 1 | 1 | 0 |
| Blood Coagulation Disorders | 0 | | 1994 | 1994 | 30.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Blood Poisoning | 0 | | 2003 | 2020 | 10.4 | low | 0 | 0 | 0 | 2 | 7 | 0 |
| Blood Pressure, High | 0 | | 2012 | 2022 | 6.4 | low | 0 | 0 | 0 | 0 | 4 | 1 |
| Blood Pressure, Low | 0 | | 1982 | 2007 | 33.7 | low | 0 | 2 | 0 | 1 | 0 | 0 |
| Body Weight | 0 | | 1961 | 2023 | 19.2 | low | 3 | 3 | 5 | 17 | 12 | 1 |
| Body Weight, Fetal | 0 | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Bone Cancer | 0 | | 1985 | 2022 | 9.1 | low | 0 | 1 | 0 | 0 | 7 | 2 |
| Bone Diseases | 0 | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Bone Loss, Osteoclastic | 0 | | 2004 | 2020 | 11.5 | low | 0 | 0 | 0 | 5 | 6 | 0 |
| Bone Loss, Perimenopausal | 0 | | 2008 | 2015 | 12.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| Bone Neoplasms | 0 | | 1985 | 2022 | 9.1 | low | 0 | 1 | 0 | 0 | 7 | 2 |
| Bovine Diseases | 0 | | 1952 | 1952 | 72.0 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| Bowel Diseases, Inflammatory | 0 | | 2017 | 2021 | 4.7 | low | 0 | 0 | 0 | 0 | 2 | 1 |
| Bradyarrhythmia | 0 | | 1993 | 2013 | 18.6 | low | 0 | 0 | 1 | 2 | 2 | 0 |
| Bradycardia | 0 | | 1993 | 2013 | 18.6 | low | 0 | 0 | 1 | 2 | 2 | 0 |
| Brain Diseases | 0 | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Brain Disorders | 0 | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Brain Edema | 0 | | 2007 | 2015 | 12.7 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| Brain Hemorrhage, Cerebral | 0 | | 2008 | 2018 | 11.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| Brain Infarction | 0 | | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Brain Inflammation | 0 | | 2008 | 2017 | 12.3 | low | 0 | 0 | 0 | 2 | 1 | 0 |
| Brain Injuries | 0 | | 2005 | 2016 | 12.0 | low | 0 | 0 | 0 | 2 | 4 | 0 |
| Brain Injuries, Traumatic | 0 | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Brain Ischemia | 0 | | 2001 | 2022 | 12.4 | low | 1 | 0 | 0 | 12 | 11 | 2 |
| Brain Neoplasms | 0 | | 2007 | 2020 | 9.2 | low | 0 | 0 | 0 | 2 | 10 | 0 |
| Brain Swelling | 0 | | 2007 | 2015 | 12.7 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| Brain Vascular Disorders | 0 | | 1964 | 2016 | 23.5 | low | 0 | 1 | 0 | 1 | 2 | 0 |
| Breast Cancer | 0 | | 1958 | 2022 | 14.9 | low | 2 | 6 | 4 | 17 | 45 | 4 |
| Breast Neoplasms | 0 | | 1958 | 2022 | 14.9 | low | 2 | 6 | 4 | 17 | 45 | 4 |
| Bronchial Diseases | 0 | | 1955 | 1962 | 65.5 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| Bronchial Hyperreactivity | 0 | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Bronchial Neoplasms | 0 | | 1968 | 1968 | 56.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Bronchial Spasm | 0 | | 1955 | 1955 | 69.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Bronchitis | 0 | | 1998 | 1998 | 26.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Bronchospasm | 0 | | 1955 | 1955 | 69.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Burkitt Lymphoma | 0 | | 2001 | 2018 | 13.7 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| Burns | 0 | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Cachexia | 0 | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Calcification, Pathologic | 0 | | 2007 | 2021 | 10.0 | low | 0 | 0 | 0 | 1 | 0 | 1 |
| Calcinosis | 0 | | 2007 | 2021 | 10.0 | low | 0 | 0 | 0 | 1 | 0 | 1 |
| Calcinosis-Raynaud Phenomenon-Sclerodactyly-Telangiectasia | 0 | | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Cancer of Cervix | 0 | | 1995 | 2019 | 15.4 | low | 0 | 0 | 1 | 5 | 4 | 0 |
| Cancer of Colon | 0 | | 1991 | 2021 | 10.9 | low | 0 | 0 | 1 | 12 | 20 | 4 |
| Cancer of Endometrium | 0 | | 2010 | 2015 | 11.0 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| Cancer of Esophagus | 0 | | 1987 | 2019 | 21.0 | low | 0 | 1 | 0 | 0 | 1 | 0 |
| Cancer of Gallbladder | 0 | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Cancer of Gastrointestinal Tract | 0 | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Cancer of Head | 0 | | 2002 | 2022 | 7.8 | low | 0 | 0 | 0 | 1 | 2 | 3 |
| Cancer of Intestines | 0 | | 1966 | 1966 | 58.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Cancer of Kidney | 0 | | 1966 | 2017 | 25.9 | low | 0 | 2 | 2 | 2 | 3 | 0 |
| Cancer of Larynx | 0 | | 1991 | 2013 | 22.0 | low | 0 | 0 | 1 | 0 | 1 | 0 |
| Cancer of Liver | 0 | | 1963 | 2023 | 17.7 | low | 1 | 10 | 5 | 12 | 24 | 7 |
| Cancer of Lung | 0 | | 1963 | 2022 | 13.8 | low | 3 | 13 | 3 | 11 | 66 | 10 |
| Cancer of Mouth | 0 | | 1970 | 2021 | 21.9 | low | 0 | 3 | 0 | 2 | 3 | 1 |
| Cancer of Nasopharynx | 0 | | 1974 | 2021 | 19.9 | low | 0 | 3 | 0 | 1 | 5 | 1 |
| Cancer of Ovary | 0 | | 2008 | 2022 | 7.1 | low | 0 | 0 | 0 | 2 | 18 | 4 |
| Cancer of Pancreas | 0 | | 2006 | 2022 | 8.9 | low | 0 | 0 | 0 | 12 | 45 | 10 |
| Cancer of Pelvis | 0 | | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Cancer of Pituitary | 0 | | 2000 | 2018 | 12.3 | low | 0 | 0 | 1 | 0 | 2 | 0 |
| Cancer of Prostate | 0 | | 2007 | 2021 | 10.2 | low | 0 | 0 | 0 | 3 | 24 | 1 |
| Cancer of Skin | 0 | | 1963 | 2022 | 38.1 | low | 0 | 39 | 2 | 4 | 6 | 1 |
| Cancer of Stomach | 0 | | 1983 | 2023 | 16.3 | low | 0 | 1 | 4 | 6 | 7 | 3 |
| Cancer of the Thyroid | 0 | | 2009 | 2021 | 8.3 | low | 0 | 0 | 0 | 2 | 2 | 3 |
| Cancer of the Tongue | 0 | | 2014 | 2017 | 8.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Cancer of the Ureter | 0 | | 1999 | 2001 | 24.0 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| Cancer of the Urinary Tract | 0 | | 2000 | 2002 | 23.5 | low | 0 | 0 | 4 | 2 | 0 | 0 |
| Cancer of the Uterus | 0 | | 1995 | 1995 | 29.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Cancer Pain | 0 | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Cancer-Associated Pain | 0 | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Carbon Tetrachloride Poisoning | 0 | | 2001 | 2011 | 19.5 | low | 0 | 0 | 0 | 3 | 1 | 0 |
| Carcinogenesis | 0 | | 1953 | 2022 | 20.4 | low | 0 | 3 | 0 | 0 | 6 | 3 |
| Carcinoma | 0 | | 1970 | 2016 | 27.3 | low | 0 | 6 | 3 | 5 | 5 | 0 |
| Carcinoma 256, Walker | 0 | | 1969 | 2014 | 37.7 | low | 0 | 2 | 0 | 0 | 1 | 0 |
| Carcinoma in Situ | 0 | | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Carcinoma, Anaplastic | 0 | | 1970 | 2016 | 27.3 | low | 0 | 6 | 3 | 5 | 5 | 0 |
| Carcinoma, Bronchial | 0 | | 1971 | 1971 | 53.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Carcinoma, Bronchogenic | 0 | | 1971 | 1971 | 53.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Carcinoma, Ductal, Breast | 0 | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Carcinoma, Ductal, Pancreatic | 0 | | 2012 | 2020 | 8.8 | low | 0 | 0 | 0 | 0 | 8 | 0 |
| Carcinoma, Ehrlich Tumor | 0 | | 1960 | 2017 | 49.0 | low | 0 | 6 | 0 | 0 | 1 | 0 |
| Carcinoma, Epidermoid | 0 | | 1966 | 2019 | 25.6 | low | 0 | 6 | 1 | 4 | 7 | 0 |
| Carcinoma, Hepatocellular | 0 | | 1963 | 2023 | 14.0 | low | 1 | 3 | 2 | 13 | 17 | 7 |
| Carcinoma, Intraepithelial | 0 | | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Carcinoma, Lewis Lung | 0 | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Carcinoma, Non-Small Cell Lung | 0 | | 2008 | 2022 | 6.5 | low | 0 | 0 | 0 | 1 | 27 | 7 |
| Carcinoma, Non-Small-Cell Lung | 0 | | 2008 | 2022 | 6.5 | low | 0 | 0 | 0 | 1 | 27 | 7 |
| Carcinoma, Ovarian Epithelial | 0 | | 2014 | 2021 | 5.3 | low | 0 | 0 | 0 | 0 | 5 | 1 |
| Carcinoma, Pancreatic Ductal | 0 | | 2012 | 2020 | 8.8 | low | 0 | 0 | 0 | 0 | 8 | 0 |
| Carcinoma, Papillary | 0 | | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Carcinoma, Renal Cell | 0 | | 2011 | 2017 | 9.7 | low | 0 | 0 | 0 | 0 | 3 | 0 |
| Carcinoma, Squamous Cell | 0 | | 1966 | 2019 | 25.6 | low | 0 | 6 | 1 | 4 | 7 | 0 |
| Carcinoma, Squamous Cell of Head and Neck | 0 | | 2019 | 2021 | 3.7 | low | 0 | 0 | 0 | 0 | 1 | 2 |
| Carcinoma, Transitional Cell | 0 | | 1966 | 2002 | 28.1 | low | 0 | 1 | 2 | 4 | 0 | 0 |
| Cardiac Arrest, Sudden | 0 | | 1994 | 2009 | 22.7 | low | 0 | 0 | 1 | 2 | 0 | 0 |
| Cardiac Death | 0 | | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Cardiac Diseases | 0 | | 1993 | 2023 | 16.4 | low | 0 | 0 | 5 | 2 | 5 | 1 |
| Cardiac Edema | 0 | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Cardiac Failure | 0 | | 1970 | 2022 | 14.1 | low | 0 | 1 | 0 | 1 | 2 | 3 |
| Cardiac Hypertrophy | 0 | | 2001 | 2016 | 18.0 | low | 0 | 0 | 0 | 8 | 1 | 0 |
| Cardiac Remodeling, Ventricular | 0 | | 2003 | 2022 | 8.2 | low | 1 | 0 | 0 | 1 | 4 | 1 |
| Cardiac Rupture, Traumatic | 0 | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Cardiac Toxicity | 0 | | 2016 | 2023 | 4.4 | low | 0 | 0 | 0 | 0 | 8 | 4 |
| Cardiomegaly | 0 | | 2001 | 2016 | 18.0 | low | 0 | 0 | 0 | 8 | 1 | 0 |
| Cardiometabolic Syndrome | 0 | | 2005 | 2017 | 11.7 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| Cardiomyopathies | 0 | | 2016 | 2021 | 6.3 | low | 0 | 0 | 0 | 0 | 2 | 1 |
| Cardiomyopathies, Primary | 0 | | 2016 | 2021 | 6.3 | low | 0 | 0 | 0 | 0 | 2 | 1 |
| Cardiomyopathy, Chagas | 0 | | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Cardiomyopathy, Hypertrophic | 0 | | 2001 | 2008 | 19.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| Cardiomyopathy, Hypertrophic Obstructive | 0 | | 2001 | 2008 | 19.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| Cardiotoxicity | 0 | | 2016 | 2023 | 4.4 | low | 0 | 0 | 0 | 0 | 8 | 4 |
| Cardiovascular Abnormalities | 0 | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Cardiovascular Diseases | 0 | | 2000 | 2021 | 10.3 | low | 1 | 0 | 1 | 3 | 4 | 2 |
| Cardiovascular Stroke | 0 | | 1981 | 2022 | 16.4 | low | 0 | 2 | 1 | 7 | 6 | 2 |
| Carditis | 0 | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Carotid Arteriopathies, Traumatic | 0 | | 2004 | 2010 | 17.3 | low | 0 | 0 | 0 | 3 | 0 | 0 |
| Carotid Artery Narrowing | 0 | | 2004 | 2006 | 19.0 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| Carotid Stenosis | 0 | | 2004 | 2006 | 19.0 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| Celiac Disease | 0 | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Celiac Sprue | 0 | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Cell Transformation, Neoplastic | 0 | | 1968 | 2022 | 27.7 | low | 0 | 10 | 4 | 5 | 7 | 1 |
| Cell Transformation, Viral | 0 | | 1980 | 2003 | 32.5 | low | 0 | 1 | 0 | 1 | 0 | 0 |
| Central Hypothyroidism | 0 | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Central Nervous System Disease | 0 | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Central Nervous System Diseases | 0 | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Cerebral Hemorrhage | 0 | | 2008 | 2018 | 11.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| Cerebral Infarction | 0 | | 2006 | 2009 | 16.3 | low | 0 | 0 | 0 | 3 | 0 | 0 |
| Cerebral Infarction, Middle Cerebral Artery | 0 | | 2001 | 2022 | 12.2 | low | 0 | 0 | 0 | 8 | 7 | 2 |
| Cerebral Ischemia | 0 | | 2001 | 2022 | 12.4 | low | 1 | 0 | 0 | 12 | 11 | 2 |
| Cerebral Malaria | 0 | | 1992 | 2014 | 23.0 | low | 0 | 0 | 2 | 0 | 1 | 0 |
| Cerebrovascular Disorders | 0 | | 1964 | 2016 | 23.5 | low | 0 | 1 | 0 | 1 | 2 | 0 |
| Chagas Cardiomyopathy | 0 | | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Chemical and Drug Induced Liver Injury | 0 | | 1984 | 2023 | 8.4 | low | 0 | 2 | 1 | 5 | 40 | 9 |
| Chemical Dependence | 0 | | 1966 | 1969 | 56.5 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| Cholangiocarcinoma | 0 | | 1998 | 2017 | 16.8 | low | 0 | 0 | 1 | 3 | 2 | 0 |
| Cholangiocellular Carcinoma | 0 | | 1998 | 2017 | 16.8 | low | 0 | 0 | 1 | 3 | 2 | 0 |
| Cholera | 0 | | 1974 | 1974 | 50.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Cholestasis | 0 | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Choroid Neovascularization | 0 | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Chromosomal Fragility | 0 | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Chromosomal Translocation | 0 | | 1976 | 2004 | 34.0 | low | 0 | 1 | 0 | 1 | 0 | 0 |
| Chromosome-Defective Micronuclei | 0 | | 2002 | 2012 | 16.7 | low | 0 | 0 | 0 | 2 | 1 | 0 |
| Chronic Disease | 0 | | 1967 | 2018 | 24.7 | low | 0 | 2 | 0 | 5 | 2 | 0 |
| Chronic Hepatitis C | 0 | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Chronic Illness | 0 | | 1967 | 2018 | 24.7 | low | 0 | 2 | 0 | 5 | 2 | 0 |
| Chronic Kidney Diseases | 0 | | 2010 | 2019 | 9.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| Chronic Kidney Failure | 0 | | 1998 | 2002 | 23.8 | low | 0 | 0 | 6 | 3 | 0 | 0 |
| Chronic Lung Injury | 0 | | 2019 | 2021 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| Chronic Pain | 0 | | 2012 | 2017 | 9.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Chronic Pancreatitis | 0 | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Cicatrix | 0 | | 2013 | 2022 | 6.5 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| Cicatrix, Hypertrophic | 0 | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Cicatrization | 0 | | 2013 | 2022 | 6.5 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| Circulatory Collapse | 0 | | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| Cirrhoses, Experimental Liver | 0 | | 2002 | 2011 | 17.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| Cirrhosis | 0 | | 1996 | 2022 | 12.2 | low | 1 | 0 | 2 | 7 | 14 | 5 |
| Cirrhosis, Liver | 0 | | 2013 | 2022 | 6.0 | low | 1 | 0 | 0 | 0 | 4 | 3 |
| Clinically Isolated CNS Demyelinating Syndrome | 0 | | 2008 | 2015 | 12.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| Coagulation Disorders, Blood | 0 | | 1994 | 1994 | 30.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Coagulation, Disseminated Intravascular | 0 | | 2012 | 2017 | 9.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Cocarcinogenesis | 0 | | 1979 | 1993 | 40.5 | low | 0 | 5 | 1 | 0 | 0 | 0 |
| Cognition Disorders | 0 | | 2014 | 2015 | 9.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Cognitive Decline | 0 | | 2016 | 2022 | 4.2 | low | 0 | 0 | 0 | 0 | 3 | 3 |
| Cognitive Dysfunction | 0 | | 2016 | 2022 | 4.2 | low | 0 | 0 | 0 | 0 | 3 | 3 |
| Colitis | 0 | | 2001 | 2022 | 10.8 | low | 0 | 0 | 0 | 7 | 6 | 3 |
| Colitis Gravis | 0 | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Colitis-Associated Cancer | 0 | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Colitis, Granulomatous | 0 | | 2010 | 2019 | 10.7 | low | 1 | 0 | 0 | 1 | 5 | 0 |
| Colitis, Mucous | 0 | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Colitis, Ulcerative | 0 | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Colonic Diseases, Functional | 0 | | 1970 | 1970 | 54.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Colonic Neoplasms | 0 | | 1991 | 2021 | 10.9 | low | 0 | 0 | 1 | 12 | 20 | 4 |
| Colorectal Cancer | 0 | | 2008 | 2022 | 7.7 | low | 0 | 0 | 0 | 3 | 12 | 5 |
| Colorectal Neoplasms | 0 | | 2008 | 2022 | 7.7 | low | 0 | 0 | 0 | 3 | 12 | 5 |
| Communicable Diseases | 0 | | 1963 | 1963 | 61.0 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| Community Acquired Infection | 0 | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Complication, Intraoperative | 0 | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Complication, Postoperative | 0 | | 1999 | 2019 | 12.3 | low | 0 | 0 | 1 | 1 | 5 | 0 |
| Complications of Diabetes Mellitus | 0 | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Complications, Parasitic Pregnancy | 0 | | 1993 | 1998 | 28.5 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| Complications, Pregnancy | 0 | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Condition, Preneoplastic | 0 | | 1975 | 2011 | 27.0 | low | 0 | 1 | 2 | 1 | 1 | 0 |
| Congestive Ophthalmopathy | 0 | | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Connective Tissue Diseases | 0 | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Contact Dermatitis | 0 | | 1970 | 1997 | 37.2 | low | 0 | 11 | 7 | 0 | 0 | 0 |
| Convulsions, Febrile | 0 | | 1992 | 1992 | 32.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Corneal Angiogenesis | 0 | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Corneal Diseases | 0 | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Corneal Neovascularization | 0 | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Coronary Artery Disease | 0 | | 1999 | 2017 | 16.3 | low | 1 | 0 | 1 | 1 | 1 | 0 |
| Coronary Disease | 0 | | 1984 | 2023 | 16.4 | low | 1 | 2 | 0 | 1 | 3 | 1 |
| Coronary Heart Disease | 0 | | 1984 | 2023 | 16.4 | low | 1 | 2 | 0 | 1 | 3 | 1 |
| Coronary Occlusion | 0 | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Coronary Restenosis | 0 | | 2005 | 2007 | 18.3 | low | 0 | 0 | 0 | 3 | 0 | 0 |
| Coronavirus Infections | 0 | | 2010 | 2020 | 7.2 | low | 0 | 0 | 0 | 1 | 3 | 0 |
| Cough | 0 | | 1957 | 2007 | 46.3 | low | 0 | 2 | 0 | 1 | 0 | 0 |
| Cranial Nerve II Injuries | 0 | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Crohn Disease | 0 | | 2010 | 2019 | 10.7 | low | 1 | 0 | 0 | 1 | 5 | 0 |
| Cross Infection | 0 | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Cryptogenic Fibrosing Alveolitis | 0 | | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Curling Ulcer | 0 | | 1968 | 1973 | 53.7 | low | 2 | 3 | 0 | 0 | 0 | 0 |
| Cystadenocarcinoma, Serous | 0 | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Cystadenoma | 0 | | 1969 | 1972 | 53.5 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| Cystic Echinococcosis | 0 | | 1994 | 1994 | 30.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Cystic Fibrosis | 0 | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Cystic Fibrosis of Pancreas | 0 | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Cytomegaloviral Retinitis | 0 | | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Cytomegalovirus | 0 | | 1979 | 1993 | 38.0 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| Cytomegalovirus Retinitis | 0 | | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Deafness, Transitory | 0 | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Death, Sudden | 0 | | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| Death, Sudden, Cardiac | 0 | | 1994 | 2009 | 22.7 | low | 0 | 0 | 1 | 2 | 0 | 0 |
| Deficiency Diseases | 0 | | 1987 | 1987 | 37.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Deficiency, Glucosephosphatase | 0 | | 1997 | 1997 | 27.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Degenerative Disc Disease | 0 | | 2020 | 2021 | 3.7 | low | 0 | 0 | 0 | 0 | 2 | 1 |
| Degenerative Diseases, Central Nervous System | 0 | | 2002 | 2022 | 7.8 | low | 0 | 0 | 0 | 2 | 3 | 3 |
| Dehydration | 0 | | 1958 | 1958 | 66.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Delayed Effects, Prenatal Exposure | 0 | | 2008 | 2023 | 7.8 | low | 0 | 0 | 0 | 1 | 2 | 2 |
| Delayed Hypersensitivity | 0 | | 1977 | 2018 | 28.3 | low | 0 | 3 | 1 | 1 | 2 | 0 |
| Dementia Praecox | 0 | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Dementia, Vascular | 0 | | 2010 | 2019 | 8.0 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| Demyelinating Diseases | 0 | | 2008 | 2015 | 12.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| Depression | 0 | | 1979 | 2017 | 20.0 | low | 1 | 1 | 0 | 0 | 2 | 0 |
| Dermatitis | 0 | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Dermatitis Medicamentosa | 0 | | 1977 | 1991 | 38.3 | low | 1 | 2 | 1 | 0 | 0 | 0 |
| Dermatitis, Allergic Contact | 0 | | 1993 | 2005 | 26.6 | low | 0 | 0 | 7 | 2 | 0 | 0 |
| Dermatitis, Atopic | 0 | | 1981 | 2018 | 24.5 | low | 0 | 1 | 0 | 0 | 1 | 0 |
| Dermatitis, Contact | 0 | | 1970 | 1997 | 37.2 | low | 0 | 11 | 7 | 0 | 0 | 0 |
| Dermatitis, Contact, Phototoxic | 0 | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Dermatitis, Eczematous | 0 | | 1983 | 2000 | 29.8 | low | 0 | 1 | 4 | 0 | 0 | 0 |
| Dermatitis, Irritant | 0 | | 1995 | 1995 | 29.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Dermatitis, Occupational | 0 | | 1994 | 1997 | 28.7 | low | 0 | 0 | 3 | 0 | 0 | 0 |
| Dermatomycoses | 0 | | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Dermatoses | 0 | | 1972 | 2007 | 29.0 | low | 0 | 1 | 0 | 2 | 0 | 0 |
| Developmental Psychomotor Disorders | 0 | | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Di Guglielmo Disease | 0 | | 1995 | 2010 | 22.7 | low | 0 | 0 | 2 | 1 | 0 | 0 |
| Diabetes Mellitus | 0 | | 2010 | 2022 | 4.3 | low | 0 | 0 | 0 | 1 | 1 | 4 |
| Diabetes Mellitus, Adult-Onset | 0 | | 2006 | 2022 | 9.2 | low | 0 | 0 | 0 | 1 | 4 | 1 |
| Diabetes Mellitus, Gestational | 0 | | 2020 | 2023 | 2.5 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| Diabetes Mellitus, Type 1 | 0 | | 2003 | 2013 | 16.3 | low | 0 | 0 | 0 | 2 | 1 | 0 |
| Diabetes Mellitus, Type 2 | 0 | | 2006 | 2022 | 9.2 | low | 0 | 0 | 0 | 1 | 4 | 1 |
| Diabetes, Gestational | 0 | | 2020 | 2023 | 2.5 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| Diabetic Angiopathies | 0 | | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Diabetic Cardiomyopathies | 0 | | 2013 | 2021 | 7.8 | low | 0 | 0 | 0 | 0 | 3 | 1 |
| Diabetic Glomerulosclerosis | 0 | | 2005 | 2022 | 7.9 | low | 1 | 0 | 0 | 4 | 9 | 5 |
| Diabetic Nephropathies | 0 | | 2005 | 2022 | 7.9 | low | 1 | 0 | 0 | 4 | 9 | 5 |
| Diabetic Neuropathies | 0 | | 2004 | 2010 | 17.0 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| Diabetic Retinopathy | 0 | | 2004 | 2017 | 13.3 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| Diarrhea | 0 | | 1971 | 1994 | 41.5 | low | 1 | 1 | 1 | 0 | 0 | 0 |
| Diarrhea, Infantile | 0 | | 1967 | 1967 | 57.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Diathesis | 0 | | 2011 | 2013 | 12.0 | low | 1 | 0 | 0 | 0 | 2 | 0 |
| Diffuse Large B-Cell Lymphoma | 0 | | 1998 | 2009 | 20.5 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| Diffuse Mixed Small and Large Cell Lymphoma | 0 | | 1971 | 2011 | 28.0 | low | 0 | 1 | 0 | 1 | 1 | 0 |
| Diffuse Parenchymal Lung Disease | 0 | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Disbacteriosis | 0 | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Disease | 0 | | 1955 | 1962 | 65.5 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| Disease Exacerbation | 0 | | 1996 | 2021 | 12.4 | low | 1 | 0 | 1 | 4 | 9 | 1 |
| Disease Models, Animal | 0 | | 1970 | 2023 | 11.8 | low | 0 | 5 | 5 | 61 | 125 | 17 |
| Disease Resistance | 0 | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Disease, Pulmonary | 0 | | 1989 | 2012 | 21.8 | low | 0 | 1 | 1 | 2 | 1 | 0 |
| Diseases, Metabolic | 0 | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Diseases, Occupational | 0 | | 1980 | 2003 | 30.7 | low | 0 | 2 | 3 | 1 | 0 | 0 |
| Disorders, Sex Chromosome | 0 | | 1959 | 1959 | 65.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Disseminated Intravascular Coagulation | 0 | | 2012 | 2017 | 9.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Dizziness | 0 | | 1994 | 1994 | 30.0 | low | 1 | 0 | 1 | 0 | 0 | 0 |
| Dizzyness | 0 | | 1994 | 1994 | 30.0 | low | 1 | 0 | 1 | 0 | 0 | 0 |
| Drop Attack | 0 | | 1994 | 1994 | 30.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Drug Hypersensitivity | 0 | | 1973 | 2008 | 40.6 | low | 1 | 5 | 1 | 1 | 0 | 0 |
| Drug Overdose | 0 | | 1992 | 1992 | 32.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Drug Withdrawal Symptoms | 0 | | 1967 | 2018 | 30.8 | low | 2 | 2 | 0 | 2 | 1 | 0 |
| Drug-Related Side Effects and Adverse Reactions | 0 | | 1973 | 2023 | 10.6 | low | 0 | 1 | 0 | 0 | 2 | 4 |
| Ductus Arteriosus, Patent | 0 | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Duodenal Diseases | 0 | | 1970 | 1970 | 54.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Duodenal Ulcer | 0 | | 1968 | 1973 | 53.7 | low | 2 | 3 | 0 | 0 | 0 | 0 |
| Dyslipidemia | 0 | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Dyslipidemias | 0 | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Dysmyelopoietic Syndromes | 0 | | 2005 | 2016 | 14.0 | low | 0 | 0 | 0 | 2 | 1 | 0 |
| Dysplastic Nevus Syndrome, Hereditary | 0 | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| E coli Infections | 0 | | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Eczema | 0 | | 1983 | 2000 | 29.8 | low | 0 | 1 | 4 | 0 | 0 | 0 |
| Eczema, Atopic | 0 | | 1981 | 2018 | 24.5 | low | 0 | 1 | 0 | 0 | 1 | 0 |
| Edema | 0 | | 1970 | 2020 | 21.3 | low | 0 | 5 | 4 | 8 | 8 | 0 |
| Edema-Proteinuria-Hypertension Gestosis | 0 | | 2005 | 2017 | 11.8 | low | 0 | 0 | 0 | 1 | 4 | 0 |
| Edema, Cardiac | 0 | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Edema, Pulmonary | 0 | | 1998 | 2011 | 19.5 | low | 0 | 0 | 1 | 0 | 1 | 0 |
| EHS Tumor | 0 | | 1953 | 1969 | 63.8 | low | 0 | 8 | 0 | 0 | 0 | 0 |
| Elaeophoriasis | 0 | | 1994 | 1994 | 30.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Electrocardiogram QT Prolonged | 0 | | 1993 | 2012 | 23.3 | low | 4 | 0 | 8 | 12 | 1 | 0 |
| Electrolytes | 0 | | 1963 | 2014 | 29.0 | low | 0 | 1 | 0 | 1 | 1 | 0 |
| Electron Transport Chain Deficiencies, Mitochondrial | 0 | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Emaciation | 0 | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Embolism | 0 | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Embolus | 0 | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Embryopathies | 0 | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Emergencies | 0 | | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Emesis | 0 | | 1975 | 2021 | 31.0 | low | 1 | 2 | 1 | 0 | 0 | 1 |
| Encephalitis | 0 | | 2008 | 2017 | 12.3 | low | 0 | 0 | 0 | 2 | 1 | 0 |
| Encephalitis, Polio | 0 | | 1962 | 1970 | 58.0 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| Encephalomyopathies, Mitochondrial | 0 | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Encephalopathy, Hepatic | 0 | | 2021 | 2021 | 3.0 | low | 1 | 0 | 0 | 0 | 0 | 1 |
| Encephalopathy, Toxic | 0 | | 2003 | 2019 | 14.4 | low | 0 | 0 | 0 | 3 | 2 | 0 |
| Encephalopathy, Traumatic | 0 | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Endocarditis, Bacterial | 0 | | 1966 | 1966 | 58.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Endocarditis, Loeffler | 0 | | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Endometrial Neoplasms | 0 | | 2010 | 2015 | 11.0 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| Endometrioma | 0 | | 1970 | 2023 | 19.0 | low | 0 | 1 | 0 | 1 | 1 | 1 |
| Endometriosis | 0 | | 1970 | 2023 | 19.0 | low | 0 | 1 | 0 | 1 | 1 | 1 |
| Endomyocardial Fibrosis | 0 | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Endotoxemia | 0 | | 2001 | 2021 | 14.0 | low | 0 | 0 | 0 | 5 | 2 | 1 |
| Endotoxin Shock | 0 | | 1993 | 2021 | 12.8 | low | 0 | 0 | 1 | 1 | 1 | 2 |
| Enlarged Spleen | 0 | | 1963 | 2006 | 37.3 | low | 0 | 1 | 1 | 1 | 0 | 0 |
| ENT Diseases | 0 | | 1967 | 1968 | 56.5 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| Enteritis | 0 | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Envenomation, Snakebite | 0 | | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Epilepsy | 0 | | 1991 | 2018 | 16.3 | low | 0 | 0 | 1 | 0 | 2 | 0 |
| Epithelial Neoplasms | 0 | | 2008 | 2018 | 10.7 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| Epithelial Ovarian Cancer | 0 | | 2014 | 2021 | 5.3 | low | 0 | 0 | 0 | 0 | 5 | 1 |
| ER-Negative PR-Negative HER2-Negative Breast Cancer | 0 | | 2013 | 2021 | 5.7 | low | 0 | 0 | 0 | 0 | 6 | 1 |
| Erectile Dysfunction | 0 | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Erythema | 0 | | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Escherichia coli Infections | 0 | | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Esophageal Neoplasms | 0 | | 1987 | 2019 | 21.0 | low | 0 | 1 | 0 | 0 | 1 | 0 |
| Esophageal Squamous Cell Carcinoma | 0 | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Exertional Heat Illness | 0 | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Experimental Hepatoma | 0 | | 1986 | 2021 | 19.9 | low | 0 | 1 | 5 | 2 | 3 | 1 |
| Experimental Leukemia | 0 | | 1959 | 1986 | 46.6 | low | 0 | 9 | 0 | 0 | 0 | 0 |
| Experimental Lung Inflammation | 0 | | 2010 | 2020 | 9.6 | low | 0 | 0 | 0 | 1 | 4 | 0 |
| Experimental Mammary Neoplasms | 0 | | 1963 | 2021 | 34.3 | low | 0 | 11 | 6 | 3 | 3 | 1 |
| Experimental Neoplasms | 0 | | 1953 | 2020 | 42.7 | low | 0 | 68 | 4 | 2 | 10 | 0 |
| Extramembranous Glomerulopathy | 0 | | 2010 | 2016 | 10.3 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| Extravascular Hemolysis | 0 | | 1968 | 2021 | 28.3 | low | 0 | 5 | 6 | 1 | 3 | 1 |
| Eye Burns | 0 | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Fasting Hypoglycemia | 0 | | 1986 | 2009 | 21.2 | low | 0 | 1 | 0 | 4 | 0 | 0 |
| Fatty Liver | 0 | | 2011 | 2015 | 11.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Fatty Liver, Nonalcoholic | 0 | | 2017 | 2021 | 4.8 | low | 0 | 0 | 0 | 0 | 3 | 2 |
| Female Genital Neoplasms | 0 | | 1970 | 1970 | 54.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Fetal Death | 0 | | 1982 | 1982 | 42.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Fetal Growth Restriction | 0 | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Fetal Growth Retardation | 0 | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Fetal Resorption | 0 | | 1982 | 1982 | 42.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Fever | 0 | | 1969 | 2016 | 37.0 | low | 2 | 4 | 2 | 1 | 1 | 0 |
| Fibroadenoma | 0 | | 1994 | 1994 | 30.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Fibroid | 0 | | 1995 | 1995 | 29.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Fibrosarcoma | 0 | | 2009 | 2011 | 14.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| Fibrosis | 0 | | 1996 | 2022 | 12.2 | low | 1 | 0 | 2 | 7 | 14 | 5 |
| Fibrosis, Radiation | 0 | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Filariasis | 0 | | 1994 | 1994 | 30.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Fish Diseases | 0 | | 1984 | 2011 | 21.0 | low | 0 | 1 | 0 | 4 | 1 | 0 |
| Fistula | 0 | | 1959 | 1959 | 65.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Flatulence | 0 | | 1970 | 1970 | 54.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Flatus | 0 | | 1970 | 1970 | 54.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| FMR1-Related Primary Ovarian Insufficiency | 0 | | 2015 | 2020 | 6.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Foreign-Body Granuloma | 0 | | 1994 | 1994 | 30.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Fowl Paralysis | 0 | | 2013 | 2016 | 9.7 | low | 0 | 0 | 0 | 0 | 3 | 0 |
| Friedreich Ataxia | 0 | | 2015 | 2016 | 8.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Friedreich Disease | 0 | | 2015 | 2016 | 8.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Furrow Keratitis | 0 | | 1980 | 1980 | 44.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Gallbladder Neoplasms | 0 | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Gastric Diseases | 0 | | 1970 | 1970 | 54.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Gastric Ulcer | 0 | | 1969 | 1972 | 53.5 | low | 1 | 2 | 0 | 0 | 0 | 0 |
| Gastritis, Atrophic | 0 | | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Gastroduodenal Ulcer | 0 | | 1968 | 2016 | 39.7 | low | 1 | 2 | 0 | 0 | 1 | 0 |
| Gastroenteritis | 0 | | 1974 | 1974 | 50.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Gastroenteritis, Transmissible, of Swine | 0 | | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Genital Neoplasms, Female | 0 | | 1970 | 1970 | 54.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Genome Instability | 0 | | 2010 | 2020 | 9.0 | low | 0 | 0 | 0 | 1 | 3 | 0 |
| Germinoblastoma | 0 | | 1963 | 1997 | 41.7 | low | 0 | 4 | 2 | 0 | 0 | 0 |
| Glaucoma | 0 | | 2013 | 2015 | 10.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Glial Cell Tumors | 0 | | 2002 | 2020 | 10.6 | low | 0 | 0 | 0 | 3 | 11 | 0 |
| Glioblastoma | 0 | | 2007 | 2021 | 7.9 | low | 0 | 0 | 0 | 1 | 7 | 2 |
| Glioma | 0 | | 2002 | 2020 | 10.6 | low | 0 | 0 | 0 | 3 | 11 | 0 |
| Glomerulonephritis, IGA | 0 | | 2015 | 2022 | 5.8 | low | 0 | 0 | 0 | 0 | 3 | 1 |
| Glomerulonephritis, Lupus | 0 | | 2006 | 2008 | 17.0 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| Glomerulonephritis, Membranous | 0 | | 2010 | 2016 | 10.3 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| Glucose Intolerance | 0 | | 2020 | 2021 | 3.5 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| Glucose Metabolic Disorder | 0 | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Glycogen Storage Disease Type I | 0 | | 1997 | 1997 | 27.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Glycosuria | 0 | | 1974 | 1974 | 50.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Gout | 0 | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Granulocytic Leukemia | 0 | | 1957 | 2013 | 30.3 | low | 0 | 2 | 1 | 3 | 1 | 0 |
| Granulocytic Leukemia, Chronic | 0 | | 2004 | 2021 | 11.7 | low | 0 | 0 | 0 | 4 | 7 | 1 |
| Granuloma | 0 | | 1969 | 1985 | 47.0 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| Granulomas | 0 | | 1969 | 1985 | 47.0 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| Graves Ophthalmopathy | 0 | | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Grippe | 0 | | 1962 | 2017 | 34.5 | low | 0 | 1 | 0 | 0 | 1 | 0 |
| Group A Strep Infection | 0 | | 2003 | 2021 | 12.0 | low | 0 | 0 | 0 | 1 | 0 | 1 |
| Gynecomastia | 0 | | 1973 | 1973 | 51.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Hallucination of Body Sensation | 0 | | 1968 | 1968 | 56.0 | low | 1 | 1 | 0 | 0 | 0 | 0 |
| Hallucinations | 0 | | 1968 | 1968 | 56.0 | low | 1 | 1 | 0 | 0 | 0 | 0 |
| Hand Dermatoses | 0 | | 1992 | 1995 | 30.5 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| Hand Dermatosis | 0 | | 1992 | 1995 | 30.5 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| Hay Fever | 0 | | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Head and Neck Neoplasms | 0 | | 2002 | 2022 | 7.8 | low | 0 | 0 | 0 | 1 | 2 | 3 |
| Headache | 0 | | 1973 | 1973 | 51.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Health Care Associated Infection | 0 | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Hearing Loss | 0 | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Heart Arrest | 0 | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Heart Disease, Ischemic | 0 | | 1996 | 2017 | 15.8 | low | 0 | 0 | 1 | 5 | 2 | 0 |
| Heart Diseases | 0 | | 1993 | 2023 | 16.4 | low | 0 | 0 | 5 | 2 | 5 | 1 |
| Heart Failure | 0 | | 1970 | 2022 | 14.1 | low | 0 | 1 | 0 | 1 | 2 | 3 |
| Heat Stroke | 0 | | 2008 | 2017 | 11.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| Heatstroke | 0 | | 2008 | 2017 | 11.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| Heavy Metal Poisoning | 0 | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Helicobacter Infections | 0 | | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Hemangioma | 0 | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Hematologic Malignancies | 0 | | 2009 | 2023 | 11.0 | low | 0 | 0 | 0 | 3 | 0 | 1 |
| Hematologic Neoplasms | 0 | | 2009 | 2023 | 11.0 | low | 0 | 0 | 0 | 3 | 0 | 1 |
| Hematuria | 0 | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Hemolysis | 0 | | 1968 | 2021 | 28.3 | low | 0 | 5 | 6 | 1 | 3 | 1 |
| Hemophilia A | 0 | | 1959 | 1959 | 65.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Hemorrhage | 0 | | 2013 | 2018 | 8.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Hemorrhage, Subarachnoid | 0 | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Hemorrhagic Shock | 0 | | 2017 | 2023 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| Hemorrhagic Thrombocythemia | 0 | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Hepatic Encephalopathy | 0 | | 2021 | 2021 | 3.0 | low | 1 | 0 | 0 | 0 | 0 | 1 |
| Hepatitis | 0 | | 2015 | 2023 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| Hepatitis C | 0 | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Hepatitis C, Chronic | 0 | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Hepatitis, Animal | 0 | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Hepatitis, Viral, Non-A, Non-B, Parenterally-Transmitted | 0 | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Hepatocellular Carcinoma | 0 | | 1963 | 2023 | 14.0 | low | 1 | 3 | 2 | 13 | 17 | 7 |
| Herpes Simplex | 0 | | 1978 | 2022 | 24.0 | low | 0 | 1 | 0 | 0 | 0 | 1 |
| Herpes Simplex Virus Infection | 0 | | 1978 | 2022 | 24.0 | low | 0 | 1 | 0 | 0 | 0 | 1 |
| Histomoniasis | 0 | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| HIV Coinfection | 0 | | 1999 | 2003 | 23.0 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| HIV Infections | 0 | | 1999 | 2003 | 23.0 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| Hives | 0 | | 1975 | 1995 | 39.0 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| Hormone-Dependent Neoplasms | 0 | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Hospital-Acquired Condition | 0 | | 1973 | 1992 | 41.5 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| HPV Infection | 0 | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Hyperaldosteronism | 0 | | 1970 | 1970 | 54.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Hypercoagulability | 0 | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Hypereosinophilic Syndrome | 0 | | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Hyperglycemia | 0 | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Hyperglycemia, Postprandial | 0 | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Hyperlipemia | 0 | | 1999 | 2012 | 17.6 | low | 0 | 0 | 1 | 5 | 1 | 0 |
| Hyperlipidemias | 0 | | 1999 | 2012 | 17.6 | low | 0 | 0 | 1 | 5 | 1 | 0 |
| Hyperplasia | 0 | | 1972 | 2018 | 22.8 | low | 0 | 3 | 1 | 6 | 3 | 0 |
| Hypersensitivity | 0 | | 1965 | 2020 | 25.7 | low | 0 | 1 | 0 | 1 | 1 | 0 |
| Hypertension | 0 | | 2012 | 2022 | 6.4 | low | 0 | 0 | 0 | 0 | 4 | 1 |
| Hypertension, Pulmonary | 0 | | 2000 | 2022 | 14.7 | low | 0 | 0 | 2 | 5 | 3 | 1 |
| Hypertriglyceridemia | 0 | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Hypertrophy | 0 | | 2008 | 2015 | 13.7 | low | 0 | 0 | 0 | 2 | 1 | 0 |
| Hypertrophy, Left Ventricular | 0 | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Hypertrophy, Right Ventricular | 0 | | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Hypoglycemia | 0 | | 1986 | 2009 | 21.2 | low | 0 | 1 | 0 | 4 | 0 | 0 |
| Hypokalemia | 0 | | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Hypopharyngeal Cancer | 0 | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Hypopharyngeal Neoplasms | 0 | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Hypospermatogenesis | 0 | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Hypotension | 0 | | 1982 | 2007 | 33.7 | low | 0 | 2 | 0 | 1 | 0 | 0 |
| Hypotension, Orthostatic | 0 | | 1972 | 1972 | 52.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Hypotension, Postural | 0 | | 1972 | 1972 | 52.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Hypothyroidism | 0 | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Hypoxia | 0 | | 1990 | 2022 | 14.2 | low | 0 | 0 | 2 | 4 | 5 | 1 |
| Hypoxia-Ischemia, Brain | 0 | | 2005 | 2007 | 18.0 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| Idiopathic Inflammatory Myopathies | 0 | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Idiopathic Parkinson Disease | 0 | | 2001 | 2022 | 13.2 | low | 0 | 0 | 0 | 7 | 4 | 1 |
| Idiopathic Pulmonary Fibrosis | 0 | | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| IgA Vasculitis | 0 | | 2011 | 2013 | 12.0 | low | 1 | 0 | 0 | 0 | 2 | 0 |
| Impaired Glucose Tolerance | 0 | | 2020 | 2021 | 3.5 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| Impotence | 0 | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Infantile Diarrhea | 0 | | 1967 | 1967 | 57.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Infantile Respiratory Distress Syndrome | 0 | | 1998 | 1998 | 26.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Infarction, Middle Cerebral Artery | 0 | | 2001 | 2022 | 12.2 | low | 0 | 0 | 0 | 8 | 7 | 2 |
| Infection | 0 | | 1956 | 1966 | 62.3 | low | 0 | 3 | 0 | 0 | 0 | 0 |
| Infection, Wound | 0 | | 1966 | 1990 | 46.0 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| Infections | 0 | | 1956 | 1966 | 62.3 | low | 0 | 3 | 0 | 0 | 0 | 0 |
| Infections, Coronavirus | 0 | | 2010 | 2020 | 7.2 | low | 0 | 0 | 0 | 1 | 3 | 0 |
| Infections, Helicobacter | 0 | | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Infections, Orthomyxoviridae | 0 | | 1970 | 1970 | 54.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Infections, Plasmodium | 0 | | 1946 | 2022 | 42.2 | low | 13 | 74 | 45 | 13 | 3 | 1 |
| Infections, Pneumococcal | 0 | | 1967 | 1967 | 57.0 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| Infections, Pseudomonas | 0 | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Infections, Salmonella | 0 | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Infections, Staphylococcal | 0 | | 1970 | 2021 | 16.2 | low | 0 | 1 | 0 | 1 | 1 | 2 |
| Infections, Staphylococcal Skin | 0 | | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Infectious Diseases | 0 | | 1963 | 1963 | 61.0 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| Infertility, Male | 0 | | 2002 | 2019 | 12.8 | low | 0 | 0 | 0 | 2 | 2 | 0 |
| Inflammation | 0 | | 1963 | 2022 | 12.6 | low | 0 | 5 | 4 | 21 | 50 | 14 |
| Inflammatory Bowel Diseases | 0 | | 2017 | 2021 | 4.7 | low | 0 | 0 | 0 | 0 | 2 | 1 |
| Inflammatory Response Syndrome, Systemic | 0 | | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Influenza, Human | 0 | | 1962 | 2017 | 34.5 | low | 0 | 1 | 0 | 0 | 1 | 0 |
| Inhalation Injury, Smoke | 0 | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Injuries, Radiation | 0 | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Injuries, Spinal Cord | 0 | | 2006 | 2022 | 10.2 | low | 0 | 0 | 0 | 3 | 5 | 1 |
| Injuries, Tendon | 0 | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Injury, Ischemia-Reperfusion | 0 | | 2002 | 2021 | 12.6 | low | 0 | 0 | 0 | 17 | 14 | 2 |
| Injury, Myocardial Reperfusion | 0 | | 1996 | 2021 | 13.7 | low | 0 | 0 | 1 | 6 | 8 | 1 |
| Innate Inflammatory Response | 0 | | 1963 | 2022 | 12.6 | low | 0 | 5 | 4 | 21 | 50 | 14 |
| Insect Bites | 0 | | 1992 | 1992 | 32.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Insect Bites and Stings | 0 | | 1992 | 1992 | 32.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Insulin Resistance | 0 | | 2011 | 2021 | 7.2 | low | 0 | 0 | 0 | 0 | 7 | 2 |
| Insulin Sensitivity | 0 | | 2011 | 2021 | 7.2 | low | 0 | 0 | 0 | 0 | 7 | 2 |
| Interstitial Nephritis | 0 | | 1996 | 2002 | 24.2 | low | 1 | 0 | 3 | 5 | 0 | 0 |
| Intervertebral Disc Degeneration | 0 | | 2020 | 2021 | 3.7 | low | 0 | 0 | 0 | 0 | 2 | 1 |
| Intestinal Diseases | 0 | | 1970 | 1970 | 54.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Intestinal Neoplasms | 0 | | 1966 | 1966 | 58.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Intestinal Polyps | 0 | | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Intraocular Pressure | 0 | | 2013 | 2015 | 10.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Invasiveness, Neoplasm | 0 | | 2006 | 2020 | 9.3 | low | 0 | 0 | 0 | 4 | 27 | 0 |
| Irritable Bowel Syndrome | 0 | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Ischemia | 0 | | 2005 | 2019 | 12.7 | low | 0 | 0 | 0 | 2 | 1 | 0 |
| Ischemic Attack, Transient | 0 | | 2006 | 2021 | 12.8 | low | 0 | 0 | 0 | 3 | 0 | 1 |
| Ischemic Stroke | 0 | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Itching | 0 | | 1989 | 1991 | 34.3 | low | 2 | 2 | 1 | 0 | 0 | 0 |
| Kahler Disease | 0 | | 2005 | 2020 | 11.5 | low | 0 | 0 | 0 | 6 | 13 | 0 |
| Kaposi Disease | 0 | | 1975 | 1980 | 46.5 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| Kaposi Sarcoma | 0 | | 2012 | 2016 | 10.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Kidney Calculi | 0 | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Kidney Diseases | 0 | | 1963 | 2020 | 20.6 | low | 0 | 1 | 8 | 6 | 7 | 0 |
| Kidney Failure | 0 | | 1996 | 2019 | 20.4 | low | 1 | 0 | 1 | 3 | 1 | 0 |
| Kidney Failure, Chronic | 0 | | 1998 | 2002 | 23.8 | low | 0 | 0 | 6 | 3 | 0 | 0 |
| Kidney Neoplasms | 0 | | 1966 | 2017 | 25.9 | low | 0 | 2 | 2 | 2 | 3 | 0 |
| Kidney Stones | 0 | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Kidney Tubular Necrosis, Acute | 0 | | 1974 | 2002 | 31.7 | low | 0 | 1 | 0 | 2 | 0 | 0 |
| Kidney, Polycystic | 0 | | 2007 | 2018 | 11.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| Koch's Disease | 0 | | 1955 | 2007 | 41.2 | low | 0 | 2 | 0 | 2 | 0 | 0 |
| Laryngeal Neoplasms | 0 | | 1991 | 2013 | 22.0 | low | 0 | 0 | 1 | 0 | 1 | 0 |
| Learning Disabilities | 0 | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Left Ventricular Hypertrophy | 0 | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Leiomyoma | 0 | | 1995 | 1995 | 29.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Leishmaniasis, American | 0 | | 1999 | 2012 | 16.7 | low | 0 | 0 | 1 | 0 | 2 | 0 |
| Leishmaniasis, Cutaneous | 0 | | 1999 | 2012 | 16.7 | low | 0 | 0 | 1 | 0 | 2 | 0 |
| Lesion of Sciatic Nerve | 0 | | 2004 | 2020 | 12.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| Leucocythaemia | 0 | | 1957 | 2022 | 22.8 | low | 0 | 5 | 1 | 4 | 8 | 1 |
| Leukemia | 0 | | 1957 | 2022 | 22.8 | low | 0 | 5 | 1 | 4 | 8 | 1 |
| Leukemia L 1210 | 0 | | 1964 | 1984 | 49.3 | low | 0 | 3 | 0 | 0 | 0 | 0 |
| Leukemia P388 | 0 | | 1981 | 2010 | 34.4 | low | 0 | 7 | 4 | 2 | 0 | 0 |
| Leukemia-Lymphoma, Adult T-Cell | 0 | | 1999 | 2015 | 17.0 | low | 0 | 0 | 1 | 0 | 1 | 0 |
| Leukemia, Erythroblastic, Acute | 0 | | 1995 | 2010 | 22.7 | low | 0 | 0 | 2 | 1 | 0 | 0 |
| Leukemia, Lymphoblastic, Acute, T Cell | 0 | | 2013 | 2015 | 10.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Leukemia, Lymphocytic | 0 | | 1976 | 2007 | 32.5 | low | 0 | 1 | 0 | 1 | 0 | 0 |
| Leukemia, Lymphocytic, Chronic, B-Cell | 0 | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Leukemia, Lymphocytic, T Cell | 0 | | 2011 | 2014 | 11.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Leukemia, Lymphoid | 0 | | 1976 | 2007 | 32.5 | low | 0 | 1 | 0 | 1 | 0 | 0 |
| Leukemia, Myelogenous, Chronic, BCR-ABL Positive | 0 | | 2004 | 2021 | 11.7 | low | 0 | 0 | 0 | 4 | 7 | 1 |
| Leukemia, Myeloid | 0 | | 1957 | 2013 | 30.3 | low | 0 | 2 | 1 | 3 | 1 | 0 |
| Leukemia, Myeloid, Acute | 0 | | 2007 | 2022 | 8.8 | low | 0 | 0 | 0 | 3 | 8 | 2 |
| Leukemia, Promyelocytic, Acute | 0 | | 1991 | 2017 | 18.5 | low | 0 | 0 | 3 | 11 | 1 | 0 |
| Leukemia, T-Cell | 0 | | 2011 | 2014 | 11.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Leukostasis | 0 | | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Libman-Sacks Disease | 0 | | 2006 | 2019 | 9.3 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| Liposarcoma | 0 | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Liver Cirrhosis | 0 | | 2013 | 2022 | 6.0 | low | 1 | 0 | 0 | 0 | 4 | 3 |
| Liver Diseases | 0 | | 1984 | 2023 | 20.5 | low | 0 | 2 | 1 | 5 | 2 | 1 |
| Liver Diseases, Alcoholic | 0 | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Liver Diseases, Parasitic | 0 | | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Liver Dysfunction | 0 | | 1984 | 2023 | 20.5 | low | 0 | 2 | 1 | 5 | 2 | 1 |
| Liver Failure, Acute | 0 | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Liver Neoplasms | 0 | | 1963 | 2023 | 17.7 | low | 1 | 10 | 5 | 12 | 24 | 7 |
| Liver Steatosis | 0 | | 2011 | 2015 | 11.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Local Neoplasm Recurrence | 0 | | 2017 | 2021 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| Long QT Syndrome | 0 | | 1993 | 2012 | 23.3 | low | 4 | 0 | 8 | 12 | 1 | 0 |
| Lung Abscess | 0 | | 1962 | 1962 | 62.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Lung Adenocarcinoma | 0 | | 2012 | 2020 | 8.3 | low | 0 | 0 | 0 | 0 | 6 | 0 |
| Lung Diseases | 0 | | 1989 | 2012 | 21.8 | low | 0 | 1 | 1 | 2 | 1 | 0 |
| Lung Diseases, Interstitial | 0 | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Lung Injury, Acute | 0 | | 2009 | 2022 | 9.8 | low | 0 | 0 | 0 | 1 | 7 | 1 |
| Lung Injury, Ventilator-Induced | 0 | | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Lung Neoplasms | 0 | | 1963 | 2022 | 13.8 | low | 3 | 13 | 3 | 11 | 66 | 10 |
| Lupus Erythematosus, Systemic | 0 | | 2006 | 2019 | 9.3 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| Lupus Nephritis | 0 | | 2006 | 2008 | 17.0 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| Lymph Node Metastasis | 0 | | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Lymphatic Diseases | 0 | | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Lymphoma | 0 | | 1963 | 1997 | 41.7 | low | 0 | 4 | 2 | 0 | 0 | 0 |
| Lymphoma, B-Cell | 0 | | 2006 | 2015 | 15.0 | low | 0 | 0 | 0 | 2 | 1 | 0 |
| Lymphoma, Large B-Cell, Diffuse | 0 | | 1998 | 2009 | 20.5 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| Lymphoma, Non-Hodgkin | 0 | | 1971 | 2011 | 28.0 | low | 0 | 1 | 0 | 1 | 1 | 0 |
| Lymphoma, Primary Effusion | 0 | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Lymphoma, T-Cell | 0 | | 1996 | 1996 | 28.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Malaria | 0 | | 1946 | 2022 | 42.2 | low | 13 | 74 | 45 | 13 | 3 | 1 |
| Malaria, Avian | 0 | | 1975 | 1975 | 49.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Malaria, Falciparum | 0 | | 1991 | 2020 | 26.9 | low | 38 | 0 | 112 | 20 | 6 | 0 |
| Malaria, Vivax | 0 | | 1947 | 2006 | 30.3 | low | 9 | 1 | 20 | 2 | 0 | 0 |
| Malignant Melanoma | 0 | | 1976 | 2022 | 13.1 | low | 0 | 2 | 0 | 2 | 11 | 3 |
| Medulloblastoma | 0 | | 2016 | 2018 | 7.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Melanoma | 0 | | 1976 | 2022 | 13.1 | low | 0 | 2 | 0 | 2 | 11 | 3 |
| Memory Disorders | 0 | | 2007 | 2016 | 13.0 | low | 0 | 0 | 0 | 3 | 2 | 0 |
| Meningitis, Bacterial | 0 | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Mental Disorders | 0 | | 2007 | 2016 | 13.2 | low | 0 | 0 | 0 | 2 | 2 | 0 |
| Mesothelioma | 0 | | 1985 | 1985 | 39.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Metabolic Diseases | 0 | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Metabolic Syndrome | 0 | | 2005 | 2017 | 11.7 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| Metastase | 0 | | 1970 | 2020 | 19.6 | low | 2 | 5 | 0 | 4 | 12 | 0 |
| Migraine Disorders | 0 | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Mitochondrial Diseases | 0 | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| MODS | 0 | | 2017 | 2018 | 6.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Morphine Abuse | 0 | | 1969 | 1971 | 54.0 | low | 1 | 2 | 0 | 0 | 0 | 0 |
| Morphine Dependence | 0 | | 1969 | 1971 | 54.0 | low | 1 | 2 | 0 | 0 | 0 | 0 |
| Mouth Neoplasms | 0 | | 1970 | 2021 | 21.9 | low | 0 | 3 | 0 | 2 | 3 | 1 |
| MPTP Neurotoxicity Syndrome | 0 | | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| MS (Multiple Sclerosis) | 0 | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Mucositis | 0 | | 2020 | 2021 | 3.5 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| Mucositis, Oral | 0 | | 1964 | 1964 | 60.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Multiple Myeloma | 0 | | 2005 | 2020 | 11.5 | low | 0 | 0 | 0 | 6 | 13 | 0 |
| Multiple Organ Failure | 0 | | 2017 | 2018 | 6.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Multiple Sclerosis | 0 | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Muscle Contraction | 0 | | 1968 | 2022 | 17.9 | low | 0 | 2 | 2 | 2 | 6 | 2 |
| Muscle Disorders | 0 | | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Muscle Pain | 0 | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Muscle Relaxation | 0 | | 1993 | 2004 | 25.5 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| Muscle Spasm | 0 | | 1955 | 1970 | 59.0 | low | 0 | 3 | 0 | 0 | 0 | 0 |
| Muscular Atrophy | 0 | | 2017 | 2020 | 5.0 | low | 0 | 0 | 0 | 0 | 3 | 0 |
| Muscular Atrophy, Spinal | 0 | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Muscular Diseases | 0 | | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Myalgia | 0 | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Myelodysplastic Syndromes | 0 | | 2005 | 2016 | 14.0 | low | 0 | 0 | 0 | 2 | 1 | 0 |
| Myelopathy | 0 | | 2004 | 2005 | 19.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| Myeloproliferative Disorders | 0 | | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Myocardial Infarction | 0 | | 1981 | 2022 | 16.4 | low | 0 | 2 | 1 | 7 | 6 | 2 |
| Myocardial Ischemia | 0 | | 1996 | 2017 | 15.8 | low | 0 | 0 | 1 | 5 | 2 | 0 |
| Myocarditis | 0 | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Myoclonic Jerk | 0 | | 1974 | 1974 | 50.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Myositis | 0 | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Myotonia | 0 | | 1971 | 1971 | 53.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Nasopharyngeal Carcinoma | 0 | | 2015 | 2021 | 6.8 | low | 0 | 0 | 0 | 0 | 4 | 1 |
| Nasopharyngeal Neoplasms | 0 | | 1974 | 2021 | 19.9 | low | 0 | 3 | 0 | 1 | 5 | 1 |
| Nausea | 0 | | 1982 | 2021 | 22.5 | low | 0 | 1 | 0 | 0 | 0 | 1 |
| Necrosis | 0 | | 1993 | 2019 | 15.1 | low | 0 | 0 | 1 | 8 | 6 | 0 |
| Neglected Diseases | 0 | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Neoplasm Metastasis | 0 | | 1970 | 2020 | 19.6 | low | 2 | 5 | 0 | 4 | 12 | 0 |
| Neoplasm Regression, Spontaneous | 0 | | 1971 | 1971 | 53.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Neoplasms | 0 | | 1946 | 2023 | 19.4 | low | 1 | 19 | 1 | 21 | 47 | 8 |
| Neoplasms, Bronchial | 0 | | 1968 | 1968 | 56.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Nephritis | 0 | | 1999 | 2013 | 16.6 | low | 1 | 0 | 1 | 1 | 3 | 0 |
| Nephritis, Interstitial | 0 | | 1996 | 2002 | 24.2 | low | 1 | 0 | 3 | 5 | 0 | 0 |
| Nephrosis | 0 | | 1974 | 2008 | 33.0 | low | 0 | 1 | 0 | 1 | 0 | 0 |
| Nephrotic Syndrome | 0 | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Nerve Degeneration | 0 | | 2005 | 2014 | 15.4 | low | 0 | 0 | 0 | 4 | 1 | 0 |
| Nerve Pain | 0 | | 2012 | 2019 | 10.2 | low | 0 | 0 | 0 | 0 | 4 | 0 |
| Nervous System Diseases | 0 | | 2004 | 2006 | 19.0 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| Nervous System Disorders | 0 | | 2004 | 2006 | 19.0 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| Neuralgia | 0 | | 2012 | 2019 | 10.2 | low | 0 | 0 | 0 | 0 | 4 | 0 |
| Neurilemmoma | 0 | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Neurilemoma | 0 | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Neuroblastoma | 0 | | 1998 | 2023 | 9.7 | low | 0 | 0 | 1 | 3 | 12 | 2 |
| Neurodegenerative Diseases | 0 | | 2002 | 2022 | 7.8 | low | 0 | 0 | 0 | 2 | 3 | 3 |
| Neuroretinitis | 0 | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Nicotine Addiction | 0 | | 2018 | 2018 | 6.0 | low | 1 | 0 | 0 | 0 | 1 | 0 |
| No-Reflow Phenomenon | 0 | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Non-alcoholic Fatty Liver Disease | 0 | | 2017 | 2021 | 4.8 | low | 0 | 0 | 0 | 0 | 3 | 2 |
| Obesity | 0 | | 2002 | 2021 | 11.8 | low | 0 | 0 | 0 | 4 | 3 | 1 |
| Opioid-Related Disorders | 0 | | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Opisthorchiasis | 0 | | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Opisthorchis felineus Infection | 0 | | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Orthomyxoviridae Infections | 0 | | 1970 | 1970 | 54.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Osteoarthritis | 0 | | 2010 | 2021 | 7.1 | low | 0 | 0 | 0 | 1 | 4 | 2 |
| Osteogenic Sarcoma | 0 | | 2013 | 2022 | 7.4 | low | 0 | 0 | 0 | 0 | 10 | 1 |
| Osteolysis | 0 | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Osteomyelitis | 0 | | 1964 | 1964 | 60.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Osteoporosis | 0 | | 2010 | 2020 | 8.5 | low | 0 | 0 | 0 | 1 | 3 | 0 |
| Osteoporosis, Postmenopausal | 0 | | 2008 | 2015 | 12.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| Osteosarcoma | 0 | | 2013 | 2022 | 7.4 | low | 0 | 0 | 0 | 0 | 10 | 1 |
| Ovarian Neoplasms | 0 | | 2008 | 2022 | 7.1 | low | 0 | 0 | 0 | 2 | 18 | 4 |
| Overweight | 0 | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Pain | 0 | | 2001 | 2016 | 13.8 | low | 0 | 0 | 0 | 3 | 3 | 0 |
| Pain, Chronic | 0 | | 2012 | 2017 | 9.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Palmoplantaris Pustulosis | 0 | | 1975 | 2018 | 19.6 | low | 1 | 1 | 0 | 1 | 3 | 0 |
| Palsy | 0 | | 1971 | 2002 | 37.5 | low | 0 | 1 | 0 | 1 | 0 | 0 |
| Pancreatic Neoplasms | 0 | | 2006 | 2022 | 8.9 | low | 0 | 0 | 0 | 12 | 45 | 10 |
| Pancreatitis | 0 | | 2005 | 2022 | 12.8 | low | 0 | 0 | 0 | 3 | 1 | 1 |
| Pancreatitis, Chronic | 0 | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Papilloma | 0 | | 1962 | 2018 | 41.5 | low | 0 | 8 | 0 | 2 | 1 | 0 |
| Papilloma, Squamous Cell | 0 | | 1962 | 2018 | 41.5 | low | 0 | 8 | 0 | 2 | 1 | 0 |
| Papillomavirus Infections | 0 | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Paraganglioma | 0 | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Paraganglioma, Gangliocytic | 0 | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Paralysis | 0 | | 1971 | 2002 | 37.5 | low | 0 | 1 | 0 | 1 | 0 | 0 |
| Parasitemia | 0 | | 1995 | 2014 | 24.3 | low | 4 | 0 | 10 | 1 | 1 | 0 |
| Parkinson Disease | 0 | | 2001 | 2022 | 13.2 | low | 0 | 0 | 0 | 7 | 4 | 1 |
| Parkinson Disease, Secondary | 0 | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Parkinsonian Disorders | 0 | | 2006 | 2012 | 15.3 | low | 0 | 0 | 0 | 2 | 1 | 0 |
| Patency of the Ductus Arteriosus | 0 | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Peptic Ulcer | 0 | | 1968 | 2016 | 39.7 | low | 1 | 2 | 0 | 0 | 1 | 0 |
| Perforated Appendicitis | 0 | | 1993 | 1994 | 30.5 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| Pericementitis | 0 | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Periodontitis | 0 | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Peripheral Arterial Disease | 0 | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Peripheral Arterial Diseases | 0 | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Peripheral Nerve Injuries | 0 | | 2012 | 2014 | 11.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Peripheral Nerve Injury | 0 | | 2012 | 2014 | 11.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Peritoneal Diseases | 0 | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Peritonitis | 0 | | 2001 | 2003 | 22.0 | low | 0 | 0 | 0 | 4 | 0 | 0 |
| Pheochromocytoma | 0 | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Pheochromocytoma, Extra-Adrenal | 0 | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Pituitary Neoplasms | 0 | | 2000 | 2018 | 12.3 | low | 0 | 0 | 1 | 0 | 2 | 0 |
| Plant Poisoning | 0 | | 1963 | 1963 | 61.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Plasmodium falciparum Malaria | 0 | | 1991 | 2020 | 26.9 | low | 38 | 0 | 112 | 20 | 6 | 0 |
| Plasmodium vivax Malaria | 0 | | 1947 | 2006 | 30.3 | low | 9 | 1 | 20 | 2 | 0 | 0 |
| Pleurisy | 0 | | 1998 | 1998 | 26.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Pneumococcal Infections | 0 | | 1967 | 1967 | 57.0 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| Pneumonia | 0 | | 2010 | 2020 | 9.6 | low | 0 | 0 | 0 | 1 | 4 | 0 |
| Pneumonia, Aspiration | 0 | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Pneumonia, Bacterial | 0 | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Pneumonia, Viral | 0 | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Poisoning | 0 | | 1999 | 2015 | 17.0 | low | 0 | 0 | 1 | 0 | 1 | 0 |
| Poliomyelitis | 0 | | 1962 | 1970 | 58.0 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| Polyarthritis | 0 | | 1964 | 2021 | 26.6 | low | 0 | 2 | 0 | 3 | 1 | 1 |
| Polycystic Kidney Diseases | 0 | | 2007 | 2018 | 11.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| Polycystic Kidney, Autosomal Dominant | 0 | | 2008 | 2021 | 10.8 | low | 0 | 0 | 0 | 2 | 1 | 1 |
| Polycystic Ovarian Syndrome | 0 | | 2008 | 2022 | 7.7 | low | 0 | 0 | 0 | 1 | 4 | 2 |
| Polycystic Ovary Syndrome | 0 | | 2008 | 2022 | 7.7 | low | 0 | 0 | 0 | 1 | 4 | 2 |
| Polyploid | 0 | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Postoperative Complications | 0 | | 1999 | 2019 | 12.3 | low | 0 | 0 | 1 | 1 | 5 | 0 |
| Pouch Ileitis | 0 | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Pouchitis | 0 | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Poultry Diseases | 0 | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Pre-Eclampsia | 0 | | 2005 | 2017 | 11.8 | low | 0 | 0 | 0 | 1 | 4 | 0 |
| Precancerous Conditions | 0 | | 1975 | 2011 | 27.0 | low | 0 | 1 | 2 | 1 | 1 | 0 |
| Precursor Cell Lymphoblastic Leukemia-Lymphoma | 0 | | 2004 | 2016 | 12.0 | low | 0 | 0 | 0 | 2 | 6 | 0 |
| Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | 0 | | 2013 | 2015 | 10.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Pregnancy | 0 | | 1967 | 2023 | 24.3 | low | 0 | 17 | 7 | 7 | 16 | 5 |
| Premature Birth | 0 | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 2 |
| Pressure Ulcer | 0 | | 1964 | 1964 | 60.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Preterm Birth | 0 | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 2 |
| Primary Myelofibrosis | 0 | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Primary Ovarian Insufficiency | 0 | | 2015 | 2020 | 6.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Primary Peritonitis | 0 | | 2001 | 2003 | 22.0 | low | 0 | 0 | 0 | 4 | 0 | 0 |
| Prostatic Hyperplasia | 0 | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Prostatic Neoplasms | 0 | | 2007 | 2021 | 10.2 | low | 0 | 0 | 0 | 3 | 24 | 1 |
| Prostatic Neoplasms, Castration-Resistant | 0 | | 2014 | 2017 | 8.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Protein Aggregation, Pathological | 0 | | 2016 | 2017 | 7.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Protein Folding Diseases | 0 | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Proteinuria | 0 | | 1974 | 2019 | 17.6 | low | 1 | 2 | 0 | 5 | 6 | 0 |
| Pruritus | 0 | | 1989 | 1991 | 34.3 | low | 2 | 2 | 1 | 0 | 0 | 0 |
| Pseudomonas Infections | 0 | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Psoriasis | 0 | | 1975 | 2018 | 19.6 | low | 1 | 1 | 0 | 1 | 3 | 0 |
| Psychoses, Drug | 0 | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Puerperal Disorders | 0 | | 1969 | 1969 | 55.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Pulmonary Arterial Remodeling | 0 | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Pulmonary Disease, Chronic Obstructive | 0 | | 2018 | 2020 | 5.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Pulmonary Edema | 0 | | 1998 | 2011 | 19.5 | low | 0 | 0 | 1 | 0 | 1 | 0 |
| Pulmonary Fibrosis | 0 | | 1994 | 2022 | 9.3 | low | 0 | 0 | 1 | 1 | 7 | 1 |
| Pulmonary Hypertension | 0 | | 2000 | 2022 | 14.7 | low | 0 | 0 | 2 | 5 | 3 | 1 |
| Pus | 0 | | 1963 | 1967 | 59.5 | low | 1 | 4 | 0 | 0 | 0 | 0 |
| Pyrexia | 0 | | 1969 | 2016 | 37.0 | low | 2 | 4 | 2 | 1 | 1 | 0 |
| Radiation Pneumonitis | 0 | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Recrudescence | 0 | | 1980 | 2011 | 28.5 | low | 6 | 3 | 18 | 5 | 1 | 0 |
| Renal Insufficiency | 0 | | 1996 | 2019 | 20.4 | low | 1 | 0 | 1 | 3 | 1 | 0 |
| Renal Insufficiency, Chronic | 0 | | 2010 | 2019 | 9.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| Reperfusion Injury | 0 | | 2002 | 2021 | 12.6 | low | 0 | 0 | 0 | 17 | 14 | 2 |
| Respiratory Distress Syndrome | 0 | | 1994 | 2021 | 16.5 | low | 0 | 0 | 1 | 0 | 0 | 1 |
| Respiratory Distress Syndrome, Newborn | 0 | | 1998 | 1998 | 26.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Respiratory Insufficiency | 0 | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Respiratory Syndrome, Acute, Severe | 0 | | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Respiratory Tract Diseases | 0 | | 2000 | 2003 | 22.5 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| Respiratory Tract Neoplasms | 0 | | 1970 | 1970 | 54.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Retinal Degeneration | 0 | | 2017 | 2021 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| Retinal Detachment | 0 | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Retinal Pigment Epithelial Detachment | 0 | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Retinitis | 0 | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Rhabdomyosarcoma | 0 | | 1970 | 1973 | 52.7 | low | 0 | 3 | 0 | 0 | 0 | 0 |
| Rheumatoid Arthritis | 0 | | 1969 | 2022 | 11.4 | low | 6 | 1 | 6 | 13 | 27 | 11 |
| Rhinitis, Allergic, Seasonal | 0 | | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Root Resorption | 0 | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Salmonella Infections, Animal | 0 | | 1970 | 1970 | 54.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Sarcoidosis | 0 | | 1970 | 1970 | 54.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Sarcoma | 0 | | 1953 | 2002 | 48.0 | low | 0 | 3 | 0 | 1 | 0 | 0 |
| Sarcoma 180 | 0 | | 1955 | 2008 | 51.8 | low | 0 | 4 | 0 | 1 | 0 | 0 |
| Sarcoma 37 | 0 | | 1953 | 1953 | 71.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Sarcoma, Epithelioid | 0 | | 1953 | 2002 | 48.0 | low | 0 | 3 | 0 | 1 | 0 | 0 |
| Sarcoma, Kaposi | 0 | | 2012 | 2016 | 10.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Scarlet Fever | 0 | | 1977 | 1980 | 45.0 | low | 0 | 3 | 0 | 0 | 0 | 0 |
| Schistosoma mansoni Infection | 0 | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Schistosomiasis | 0 | | 2013 | 2014 | 10.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Schistosomiasis mansoni | 0 | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Schizophrenia | 0 | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Scleroderma, Systemic | 0 | | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Sclerosis, Systemic | 0 | | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Sebaceous Gland Diseases | 0 | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Seizures | 0 | | 1969 | 1974 | 52.3 | low | 1 | 3 | 0 | 0 | 0 | 0 |
| Seizures, Febrile | 0 | | 1992 | 1992 | 32.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Sensitivity and Specificity | 0 | | 1994 | 2021 | 18.9 | low | 0 | 0 | 12 | 40 | 8 | 1 |
| Sepsis | 0 | | 2003 | 2020 | 10.4 | low | 0 | 0 | 0 | 2 | 7 | 0 |
| Severe Acute Respiratory Syndrome | 0 | | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Shock | 0 | | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| Shock, Septic | 0 | | 1993 | 2021 | 12.8 | low | 0 | 0 | 1 | 1 | 1 | 2 |
| Silicosis | 0 | | 2019 | 2020 | 4.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Skin Diseases | 0 | | 1972 | 2007 | 29.0 | low | 0 | 1 | 0 | 2 | 0 | 0 |
| Skin Neoplasms | 0 | | 1963 | 2022 | 38.1 | low | 0 | 39 | 2 | 4 | 6 | 1 |
| Sleepiness | 0 | | 2021 | 2021 | 3.0 | low | 1 | 0 | 0 | 0 | 0 | 1 |
| Smoking Cessation | 0 | | 2018 | 2022 | 4.0 | low | 1 | 0 | 0 | 0 | 1 | 1 |
| Soft Tissue Neoplasms | 0 | | 1985 | 1985 | 39.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Spasm | 0 | | 1955 | 1970 | 59.0 | low | 0 | 3 | 0 | 0 | 0 | 0 |
| Spinal Cord Diseases | 0 | | 2004 | 2005 | 19.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| Spinal Cord Injuries | 0 | | 2006 | 2022 | 10.2 | low | 0 | 0 | 0 | 3 | 5 | 1 |
| Spondylitis, Ankylosing | 0 | | 2018 | 2022 | 4.3 | low | 0 | 0 | 0 | 0 | 2 | 1 |
| Squamous Cell Carcinoma of Head and Neck | 0 | | 2019 | 2021 | 3.7 | low | 0 | 0 | 0 | 0 | 1 | 2 |
| Staphylococcal Infections | 0 | | 1970 | 2021 | 16.2 | low | 0 | 1 | 0 | 1 | 1 | 2 |
| Staphylococcal Skin Infections | 0 | | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Starvation | 0 | | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Status Epilepticus | 0 | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Sterility, Male | 0 | | 2002 | 2019 | 12.8 | low | 0 | 0 | 0 | 2 | 2 | 0 |
| Stomach Neoplasms | 0 | | 1983 | 2023 | 16.3 | low | 0 | 1 | 4 | 6 | 7 | 3 |
| Stomach Ulcer | 0 | | 1969 | 1972 | 53.5 | low | 1 | 2 | 0 | 0 | 0 | 0 |
| Stomatitis | 0 | | 1964 | 1964 | 60.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Streptococcal Infections | 0 | | 2003 | 2021 | 12.0 | low | 0 | 0 | 0 | 1 | 0 | 1 |
| Stroke | 0 | | 2001 | 2022 | 11.3 | low | 1 | 0 | 0 | 6 | 7 | 2 |
| Subarachnoid Hemorrhage | 0 | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Substance Withdrawal Syndrome | 0 | | 1967 | 2018 | 30.8 | low | 2 | 2 | 0 | 2 | 1 | 0 |
| Substance-Related Disorders | 0 | | 1966 | 1969 | 56.5 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| Sunburn | 0 | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Symptom Cluster | 0 | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Syncope | 0 | | 1994 | 1994 | 30.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Syndrome | 0 | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Systemic Inflammatory Response Syndrome | 0 | | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| T-Cell Lymphoma | 0 | | 1996 | 1996 | 28.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Tachycardia, Ventricular | 0 | | 1994 | 2001 | 26.5 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| Thrombocythemia, Essential | 0 | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Thrombocytopenia | 0 | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Thrombopenia | 0 | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Thrombophilia | 0 | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Thrombosis | 0 | | 1984 | 2018 | 20.3 | low | 0 | 1 | 0 | 1 | 1 | 0 |
| Thyroid Cancer, Anaplastic | 0 | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 2 |
| Thyroid Carcinoma, Anaplastic | 0 | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 2 |
| Thyroid Neoplasms | 0 | | 2009 | 2021 | 8.3 | low | 0 | 0 | 0 | 2 | 2 | 3 |
| Tobacco Use Disorder | 0 | | 2018 | 2018 | 6.0 | low | 1 | 0 | 0 | 0 | 1 | 0 |
| Tongue Neoplasms | 0 | | 2014 | 2017 | 8.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Tonsillitis | 0 | | 1966 | 1966 | 58.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Torsade de Pointes | 0 | | 1993 | 2005 | 25.5 | low | 0 | 0 | 2 | 2 | 0 | 0 |
| Tracheal Neoplasms | 0 | | 1968 | 1968 | 56.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Tracheal Stenosis | 0 | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Triple Negative Breast Neoplasms | 0 | | 2013 | 2021 | 5.7 | low | 0 | 0 | 0 | 0 | 6 | 1 |
| Triploid | 0 | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Trypanosomiasis | 0 | | 1952 | 2001 | 63.5 | low | 0 | 5 | 0 | 1 | 0 | 0 |
| Trypanosomiasis, African | 0 | | 1954 | 1954 | 70.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Tuberculosis | 0 | | 1955 | 2007 | 41.2 | low | 0 | 2 | 0 | 2 | 0 | 0 |
| Uremia | 0 | | 1984 | 1984 | 40.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Ureteral Neoplasms | 0 | | 1999 | 2001 | 24.0 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| Ureteral Obstruction | 0 | | 2011 | 2018 | 9.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Urinary Bladder Neoplasms | 0 | | 1972 | 2021 | 18.1 | low | 0 | 1 | 1 | 2 | 3 | 1 |
| Urinary Tract Infections | 0 | | 1991 | 1991 | 33.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Urticaria | 0 | | 1975 | 1995 | 39.0 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| Uterine Cervical Neoplasms | 0 | | 1995 | 2019 | 15.4 | low | 0 | 0 | 1 | 5 | 4 | 0 |
| Uterine Neoplasms | 0 | | 1995 | 1995 | 29.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Uveitis | 0 | | 2001 | 2003 | 22.0 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| Vascular Calcification | 0 | | 2019 | 2020 | 4.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Vascular Diseases | 0 | | 2002 | 2020 | 13.0 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| Vasospasm, Intracranial | 0 | | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Ventricular Fibrillation | 0 | | 1997 | 1997 | 27.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Vibrio cholerae Infection | 0 | | 1974 | 1974 | 50.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Viral Diseases | 0 | | 1980 | 1980 | 44.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Virus Diseases | 0 | | 1980 | 1980 | 44.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Vomiting | 0 | | 1975 | 2021 | 31.0 | low | 1 | 2 | 1 | 0 | 0 | 1 |
| Weight Gain | 0 | | 1961 | 2010 | 36.0 | low | 0 | 1 | 1 | 1 | 0 | 0 |
| Weight Loss | 0 | | 1999 | 2020 | 15.0 | low | 0 | 0 | 1 | 1 | 1 | 0 |
| Weight Reduction | 0 | | 1999 | 2020 | 15.0 | low | 0 | 0 | 1 | 1 | 1 | 0 |
| Wilms Tumor | 0 | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Xeroderma Pigmentosum | 0 | | 1975 | 1980 | 46.5 | low | 0 | 2 | 0 | 0 | 0 | 0 |
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Cancer-associated fibroblasts treated with cisplatin facilitates chemoresistance of lung adenocarcinoma through IL-11/IL-11R/STAT3 signaling pathway.Scientific reports, , 12-06, Volume: 6, 2016
Triptolide reverses the Taxol resistance of lung adenocarcinoma by inhibiting the NF-κB signaling pathway and the expression of NF-κB-regulated drug-resistant genes.Molecular medicine reports, , Volume: 13, Issue:1, 2016
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Construction of a pH-responsive, ultralow-dose triptolide nanomedicine for safe rheumatoid arthritis therapy.Acta biomaterialia, , Volume: 121, 2021
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The Study of Cellular Mechanism of Triptolide in the Treatment of Cancer, Bone Loss and Cardiovascular Disease and Triptolide's Toxicity.Current stem cell research & therapy, , Volume: 15, Issue:1, 2020
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Triptolide promotes autophagy to inhibit mesangial cell proliferation in IgA nephropathy via the CARD9/p38 MAPK pathway.Cell proliferation, , Volume: 55, Issue:9, 2022
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Dihydroisotanshinone I as a Treatment Option for Head and Neck Squamous Cell Carcinomas.International journal of molecular sciences, , Aug-18, Volume: 22, Issue:16, 2021
Triptolide represses oral cancer cell proliferation, invasion, migration, and angiogenesis in co-inoculation with U937 cells.Clinical oral investigations, , Volume: 21, Issue:1, 2017
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PARP1 Inhibition and Effect on Burn Injury-Induced Inflammatory Response and Cardiac Function.Journal of the American College of Surgeons, , 04-01, Volume: 236, Issue:4, 2023
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Effect of Ghrelin Intervention on the Ras/ERK Pathway in the Regulation of Heart Failure by PTEN.Computational and mathematical methods in medicine, , Volume: 2022, 2022
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Triptolide inhibits oxidative stress and inflammation via the microRNA-155-5p/brain-derived neurotrophic factor to reduce podocyte injury in mice with diabetic nephropathy.Bioengineered, , Volume: 13, Issue:5, 2022
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Triptolide Attenuates Muscular Inflammation and Oxidative Stress in a Delayed-Onset Muscle Soreness Animal Model.International journal of environmental research and public health, , 12-12, Volume: 19, Issue:24, 2022
Triptolide Suppresses NF-κB-Mediated Inflammatory Responses and Activates Expression of Nrf2-Mediated Antioxidant Genes to Alleviate Caerulein-Induced Acute Pancreatitis.International journal of molecular sciences, , Jan-23, Volume: 23, Issue:3, 2022
Sodium Tanshinone IIA Sulfonate Improves Adverse Ventricular Remodeling Post-MI by Reducing Myocardial Necrosis, Modulating Inflammation, and Promoting Angiogenesis.Current pharmaceutical design, , Volume: 28, Issue:9, 2022
Tanshinone IIA sodium sulfonate attenuates inflammation by upregulating circ-Sirt1 and inhibiting the entry of NF-κB into the nucleus.European journal of pharmacology, , Jan-05, Volume: 914, 2022
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Tanshinones inhibit NLRP3 inflammasome activation by alleviating mitochondrial damage to protect against septic and gouty inflammation.International immunopharmacology, , Volume: 97, 2021
Triptolide: reflections on two decades of research and prospects for the future.Natural product reports, , 04-28, Volume: 38, Issue:4, 2021
Triptolide promotes the apoptosis and attenuates the inflammation of fibroblast-like synoviocytes in rheumatoid arthritis by down-regulating lncRNA ENST00000619282.Phytotherapy research : PTR, , Volume: 35, Issue:8, 2021
Triptolide regulates oxidative stress and inflammation leading to hepatotoxicity via inducing CYP2E1.Human & experimental toxicology, , Volume: 40, Issue:12_suppl, 2021
Triptolide improves neurobehavioral functions, inflammation, and oxidative stress in rats under deep hypothermic circulatory arrest.Aging, , 01-19, Volume: 13, Issue:2, 2021
Activation of AMPK by triptolide alleviates nonalcoholic fatty liver disease by improving hepatic lipid metabolism, inflammation and fibrosis.Phytomedicine : international journal of phytotherapy and phytopharmacology, , Volume: 92, 2021
Cryptotanshinone ameliorates the pathogenicity of Streptococcus suis by targeting suilysin and inflammation.Journal of applied microbiology, , Volume: 130, Issue:3, 2021
Sodium Tanshinone IIA Sulfonate Protects Against Cerebral Ischemia-reperfusion Injury by Inhibiting Autophagy and Inflammation.Neuroscience, , 08-10, Volume: 441, 2020
A network pharmacology approach to investigate the anti-inflammatory mechanism of effective ingredients from Salvia miltiorrhiza.International immunopharmacology, , Volume: 81, 2020
Cryptotanshinone enhances wound healing in type 2 diabetes with modulatory effects on inflammation, angiogenesis and extracellular matrix remodelling.Pharmaceutical biology, , Volume: 58, Issue:1, 2020
TFEB-NF-κB inflammatory signaling axis: a novel therapeutic pathway of Dihydrotanshinone I in doxorubicin-induced cardiotoxicity.Journal of experimental & clinical cancer research : CR, , May-24, Volume: 39, Issue:1, 2020
Cryptotanshinone: A review of its pharmacology activities and molecular mechanisms.Fitoterapia, , Volume: 145, 2020
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Newly synthesized phenanthroimidazole derivatives L082 as a safe anti-tumor and anti-injury inflammation bifunctional compound.European journal of pharmacology, , Dec-15, Volume: 889, 2020
Cryptotanshinone protects dextran sulfate sodium-induced experimental ulcerative colitis in mice by inhibiting intestinal inflammation.Phytotherapy research : PTR, , Volume: 34, Issue:10, 2020
Cryptotanshinone ameliorates placental oxidative stress and inflammation in mice with gestational diabetes mellitus.Archives of pharmacal research, , Volume: 43, Issue:7, 2020
Cryptotanshinone attenuates allergic airway inflammation through negative regulation of NF-κB and p38 MAPK.Bioscience, biotechnology, and biochemistry, , Volume: 84, Issue:2, 2020
Protein translation associated to PERK arm is a new target for regulation of metainflammation: A connection with hepatocyte cholesterol.Journal of cellular biochemistry, , Volume: 120, Issue:3, 2019
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Triptolide up-regulates metabotropic glutamate receptor 5 to inhibit microglia activation in the lipopolysaccharide-induced model of Parkinson's disease.Brain, behavior, and immunity, , Volume: 71, 2018
Sodium tanshinone IIA sulfonate prevents lipopolysaccharide-induced inflammation via suppressing nuclear factor-κB signaling pathway in human umbilical vein endothelial cells.Canadian journal of physiology and pharmacology, , Volume: 96, Issue:1, 2018
Triptolide inhibits the inflammatory activities of neutrophils to ameliorate chronic arthritis.Molecular immunology, , Volume: 101, 2018
Improved Reperfusion and Vasculoprotection by the Poly(ADP-Ribose)Polymerase Inhibitor PJ34 After Stroke and Thrombolysis in Mice.Molecular neurobiology, , Volume: 55, Issue:12, 2018
Triptolide inhibits donor-specific antibody production and attenuates mixed antibody-mediated renal allograft injury.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, , Volume: 18, Issue:5, 2018
Cryptotanshinone Attenuates Oxidative Stress and Inflammation through the Regulation of Nrf-2 and NF-κB in Mice with Unilateral Ureteral Obstruction.Basic & clinical pharmacology & toxicology, , Volume: 123, Issue:6, 2018
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Triptolide mitigates radiation-induced pneumonitis via inhibition of alveolar macrophages and related inflammatory molecules.Oncotarget, , Jul-11, Volume: 8, Issue:28, 2017
Sodium tanshinone IIA sulfonate improves inflammation, aortic endothelial cell apoptosis, disseminated intravascular coagulation and multiple organ damage in a rat heat stroke model.Molecular medicine reports, , Volume: 16, Issue:1, 2017
Cryptotanshinone protects against IL-1β-induced inflammation in human osteoarthritis chondrocytes and ameliorates the progression of osteoarthritis in mice.International immunopharmacology, , Volume: 50, 2017
Tanshinone IIA Sodium sulfonate regulates antioxidant system, inflammation, and endothelial dysfunction in atherosclerosis by downregulation of CLIC1.European journal of pharmacology, , Nov-15, Volume: 815, 2017
Triptolide-Assisted Phosphorylation of p53 Suppresses Inflammation-Induced NF-κB Survival Pathways in Cancer Cells.Molecular and cellular biology, , 08-01, Volume: 37, Issue:15, 2017
Sodium tanshinone IIA sulfonate attenuates hemorrhagic shock-induced organ damages by nuclear factor-kappa B pathway.The Journal of surgical research, , Volume: 209, 2017
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Triptolide downregulates Treg cells and the level of IL-10, TGF-β, and VEGF in melanoma-bearing mice.Planta medica, , Volume: 79, Issue:15, 2013
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Tanshinone congeners improve memory impairments induced by scopolamine on passive avoidance tasks in mice.European journal of pharmacology, , Nov-28, Volume: 574, Issue:2-3, 2007
Triptolide suppresses oral cancer cell PD-L1 expression in the interferon-γ-modulated microenvironment in vitro, in vivo, and in clinical patients.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 133, 2021
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Triptolide alters histone H3K9 and H3K27 methylation state and induces G0/G1 arrest and caspase-dependent apoptosis in multiple myeloma in vitro.Toxicology, , Jan-12, Volume: 267, Issue:1-3, 2010
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Interleukin-6-independent expression of glucocorticoid receptor is upregulated by triptolide in multiple myeloma.Leukemia & lymphoma, , Volume: 50, Issue:5, 2009
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MAPKs are not involved in triptolide-induced cell growth inhibition and apoptosis in prostate cancer cell lines with different p53 status.Planta medica, , Volume: 77, Issue:1, 2011
Inhibition of tumor cellular proteasome activity by triptolide extracted from the Chinese medicinal plant 'thunder god vine'.Anticancer research, , Volume: 31, Issue:1, 2011
Cryptotanshinone sensitizes DU145 prostate cancer cells to Fas(APO1/CD95)-mediated apoptosis through Bcl-2 and MAPK regulation.Cancer letters, , Dec-01, Volume: 298, Issue:1, 2010
Cryptotanshinone inhibits constitutive signal transducer and activator of transcription 3 function through blocking the dimerization in DU145 prostate cancer cells.Cancer research, , Jan-01, Volume: 69, Issue:1, 2009
[Effects of triptolide on prostate carcinoma in mouse RM-1 cells].Zhonghua nan ke xue = National journal of andrology, , Volume: 13, Issue:3, 2007
Triptolide ameliorates lupus via the induction of miR-125a-5p mediating Treg upregulation.International immunopharmacology, , Volume: 71, 2019
Triptolide attenuates proteinuria and podocyte apoptosis via inhibition of NF-κB/GADD45B.Scientific reports, , Jul-18, Volume: 8, Issue:1, 2018
Triptolide delays disease progression in an adult rat model of polycystic kidney disease through the JAK2-STAT3 pathway.American journal of physiology. Renal physiology, , 09-01, Volume: 315, Issue:3, 2018
Triptolide-containing formulation in patients with autosomal dominant polycystic kidney disease and proteinuria: an uncontrolled trial.American journal of kidney diseases : the official journal of the National Kidney Foundation, , Volume: 63, Issue:6, 2014
Efficacy of triptolide for children with moderately severe Henoch-Schönlein purpura nephritis presenting with nephrotic range proteinuria: a prospective and controlled study in China.BioMed research international, , Volume: 2013, 2013
Clinical outcomes in children with Henoch-Schönlein purpura nephritis grade IIIa or IIIb.Pediatric nephrology (Berlin, Germany), , Volume: 26, Issue:7, 2011
Triptolide reduces proteinuria in experimental membranous nephropathy and protects against C5b-9-induced podocyte injury in vitro.Kidney international, , Volume: 77, Issue:11, 2010
Renoprotective effect of Tanshinone IIA, an active component of Salvia miltiorrhiza, on rats with chronic kidney disease.Phytotherapy research : PTR, , Volume: 24, Issue:12, 2010
Protective effect of Tanshinone IIA on the early stage of experimental diabetic nephropathy.Biological & pharmaceutical bulletin, , Volume: 32, Issue:2, 2009
Triptolide protects podocytes from puromycin aminonucleoside induced injury in vivo and in vitro.Kidney international, , Volume: 74, Issue:5, 2008
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Cryptotanshinone reduces psoriatic epidermal hyperplasia via inhibiting the activation of STAT3.Experimental dermatology, , Volume: 27, Issue:3, 2018
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Inhalable cryptotanshinone spray-dried swellable microparticles for pulmonary fibrosis therapy by regulating TGF-β1/Smad3, STAT3 and SIRT3 pathways.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, , Volume: 172, 2022
Triptolide alleviates radiation-induced pulmonary fibrosis via inhibiting IKKβ stimulated LOX production.Biochemical and biophysical research communications, , 06-18, Volume: 527, Issue:1, 2020
Cryptotanshinone reverses the epithelial-mesenchymal transformation process and attenuates bleomycin-induced pulmonary fibrosis.Phytotherapy research : PTR, , Volume: 34, Issue:10, 2020
Salvianolic acid B and sodium tanshinone II A sulfonate prevent pulmonary fibrosis through anti-inflammatory and anti-fibrotic process.European journal of pharmacology, , Sep-15, Volume: 883, 2020
Sodium tanshinone IIA sulfonate attenuates silica-induced pulmonary fibrosis in rats via activation of the Nrf2 and thioredoxin system.Environmental toxicology and pharmacology, , Volume: 80, 2020
Cryptotanshinone protects against pulmonary fibrosis through inhibiting Smad and STAT3 signaling pathways.Pharmacological research, , Volume: 147, 2019
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Activation of dynamin-related protein 1 - dependent mitochondria fragmentation and suppression of osteosarcoma by cryptotanshinone.Journal of experimental & clinical cancer research : CR, , Jan-28, Volume: 38, Issue:1, 2019
Triptolide inhibits the growth of osteosarcoma by regulating microRNA-181a via targeting PTEN gene in vivo and vitro.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, , Volume: 39, Issue:4, 2017
AMD3100 combined with triptolide inhibit proliferation, invasion and metastasis and induce apoptosis of human U2OS osteosarcoma cells.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 86, 2017
15,16-dihydrotanshinone I Induces Apoptosis and Inhibits the Proliferation, Migration of Human Osteosarcoma Cell Line 143B in vitro.Anti-cancer agents in medicinal chemistry, , Volume: 17, Issue:9, 2017
[Cryptotanshinone down-regulates the expression of VEGF and inhibits angiogenesis in U2OS osteosarcoma cells].Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, , Volume: 32, Issue:1, 2016
Triptolide induces the cell apoptosis of osteosarcoma cells through the TRAIL pathway.Oncology reports, , Volume: 36, Issue:3, 2016
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A sensitive LC-MS/MS method for the determination of triptolide and its application to pharmacokinetic research in rats.Biomedical chromatography : BMC, , Volume: 33, Issue:3, 2019
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Identification of in vivo and in vitro metabolites of triptolide by liquid chromatography-tandem mass spectrometry.Journal of pharmaceutical and biomedical analysis, , Volume: 70, 2012
A high-sensitivity UPLC-MS/MS method for simultaneous determination and confirmation of triptolide in zebrafish embryos.Biomedical chromatography : BMC, , Volume: 25, Issue:8, 2011
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Simultaneous determination of triptolide, tripdiolide and tripterine in human urine by high-performance liquid chromatography coupled with ion trap atmospheric-pressure chemical ionization mass spectrometry.Biomedical chromatography : BMC, , Volume: 23, Issue:3, 2009
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Determination of tanshinone I in rat plasma by high-performance liquid chromatography and its application to pharmacokinetic studies.Journal of chromatographic science, , Volume: 46, Issue:8, 2008
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Study of tanshinone IIA tissue distribution in rat by liquid chromatography-tandem mass spectrometry method.Biomedical chromatography : BMC, , Volume: 21, Issue:5, 2007
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Coupling continuous ultrasound-assisted extraction with ultrasonic probe, solid-phase extraction and high-performance liquid chromatography for the determination of sodium Danshensu and four tanshinones in Salvia miltiorrhiza bunge.Analytica chimica acta, , Apr-25, Volume: 589, Issue:2, 2007
Simultaneous determination and pharmacokinetic study of water-soluble and lipid-soluble components of danshen in rat plasma using HPLC-UV method.Biomedical chromatography : BMC, , Volume: 21, Issue:11, 2007
Kinetic release of triptolide after injection of renal-targeting 14-succinyl triptolide-lysozyme in a rat kidney study by liquid chromatography/mass spectrometry.Biomedical chromatography : BMC, , Volume: 21, Issue:7, 2007
Simultaneous determination of danshensu, ferulic acid, cryptotanshinone and tanshinone IIA in rabbit plasma by HPLC and their pharmacokinetic application in danxiongfang.Journal of pharmaceutical and biomedical analysis, , Sep-03, Volume: 44, Issue:5, 2007
Development of capillary column packed with thiol-modified gold-coated polystyrene particles and its selectivity for aromatic compounds.Journal of chromatography. A, , Mar-31, Volume: 1110, Issue:1-2, 2006
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CF3 Rotation in 3-(Trifluoromethyl)phenanthrene: Solid State 19F and 1H NMR relaxation and Bloch-Wangsness-Redfield theory.The journal of physical chemistry. A, , Mar-23, Volume: 110, Issue:11, 2006
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Determination of cryptotanshinone and its metabolite in rat plasma by liquid chromatography-tandem mass spectrometry.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, , Dec-05, Volume: 827, Issue:2, 2005
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Determination of phenanthrene and hydroxyphenanthrenes in various biological matrices at trace levels using gas chromatography-mass spectrometry.Journal of analytical toxicology, , Volume: 29, Issue:3, 2005
Highly sensitive and selective determination of 9, 10-phenanthrenequinone in airborne particulates using high-performance liquid chromatography with pre-column derivatization and fluorescence detection.Journal of chromatography. A, , Nov-19, Volume: 1057, Issue:1-2, 2004
Identification of the 'wrong' active pharmaceutical ingredient in a counterfeit Halfan drug product using accurate mass electrospray ionisation mass spectrometry, accurate mass tandem mass spectrometry and liquid chromatography/mass spectrometry.Rapid communications in mass spectrometry : RCM, , Volume: 17, Issue:3, 2003
High-performance liquid chromatographic determination for aristolochic acid in medicinal plants and slimming products.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, , Jan-05, Volume: 766, Issue:1, 2002
A new high-performance liquid chromatography (HPLC) method for the analysis of halofantrine (HF) in pharmaceuticals.Journal of pharmaceutical and biomedical analysis, , Jul-31, Volume: 29, Issue:5, 2002
Sensitive through-space dipolar correlations between nuclei of small organic molecules by partial alignment in a deuterated liquid solvent.Journal of the American Chemical Society, , Dec-18, Volume: 124, Issue:50, 2002
Selective flotation-separation and spectrophotometric determination of cadmium using phenanthraquinone monophenythiosemicarbazone.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, , Volume: 18, Issue:11, 2002
Detecting aristolochic acids in herbal remedies by liquid chromatography/serial mass spectrometry.Rapid communications in mass spectrometry : RCM, , Volume: 16, Issue:6, 2002
Carbon and nitrogen mineralization in soil amended with phenanthrene, anthracene and irradiated sewage sludge.Bioresource technology, , Volume: 85, Issue:3, 2002
[Determination of triptolide in human plasma by gas chromatography-electron capture detection].Se pu = Chinese journal of chromatography, , Volume: 19, Issue:1, 2001
Spectrophotometric and AAS determinations of trace zinc(II) in natural waters and human blood after preconcentration with phenanthraquinone monophenylthiosemicarbazone.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, , Volume: 17, Issue:4, 2001
Assessing the aerobic biodegradability of 14 hydrocarbons in two soils using a simple microcosm/respiration method.Chemosphere, , Volume: 45, Issue:6-7, 2001
Spectrofluorimetric determination of streptomycin in dosage forms and in spiked plasma using 9,10-phenanthraquinone.Journal of pharmaceutical and biomedical analysis, , Volume: 26, Issue:3, 2001
A fluorescence spectroscopic study of phenanthrene sorption on porous silica.Environmental science & technology, , Jul-01, Volume: 35, Issue:13, 2001
Selective flotation-spectrophotometric determination of trace copper(II) in natural waters, human blood and drug samples using phenanthraquinone monophenylthiosemicarbazone.Chemical & pharmaceutical bulletin, , Volume: 49, Issue:6, 2001
Screening the foods of an endangered parrot, the kakapo (Strigops habroptilus), for oestrogenic activity using a recombinant yeast bioassay.Reproduction, fertility, and development, , Volume: 12, Issue:3-4, 2000
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Cryptotanshinone specifically suppresses NLRP3 inflammasome activation and protects against inflammasome-mediated diseases.Pharmacological research, , Volume: 164, 2021
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Sodium Tanshinone IIA Sulfonate Improves Hemodynamic Parameters, Cytokine Release, and Multi-Organ Damage in Endotoxemia Rabbits.Medical science monitor : international medical journal of experimental and clinical research, , May-08, Volume: 24, 2018
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αvβ3 integrin-specific exosomes engineered with cyclopeptide for targeted delivery of triptolide against malignant melanoma.Journal of nanobiotechnology, , Aug-23, Volume: 20, Issue:1, 2022
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Cryptotanshinone induces melanoma cancer cells apoptosis via ROS-mitochondrial apoptotic pathway and impairs cell migration and invasion.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 82, 2016
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Triptolide Attenuates Inflammatory Response in Membranous Glomerulo-Nephritis Rat via Downregulation of NF-κB Signaling Pathway.Kidney & blood pressure research, , Volume: 41, Issue:6, 2016
Renal targeted delivery of triptolide by conjugation to the fragment peptide of human serum albumin.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, , Volume: 94, 2015
Triptolide reduces proteinuria in experimental membranous nephropathy and protects against C5b-9-induced podocyte injury in vitro.Kidney international, , Volume: 77, Issue:11, 2010
Cryptotanshinone enhances the efficacy of Bcr-Abl tyrosine kinase inhibitors via inhibiting STAT3 and eIF4E signalling pathways in chronic myeloid leukaemia.Pharmaceutical biology, , Volume: 59, Issue:1, 2021
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Growth-inhibitory and apoptosis-inducing effects of tanshinones on hematological malignancy cells and their structure-activity relationship.Anti-cancer drugs, , Volume: 23, Issue:8, 2012
Activation of apoptosis signaling eliminates CD34+ progenitor cells in blast crisis CML independent of response to tyrosine kinase inhibitors.Leukemia, , Volume: 26, Issue:4, 2012
Cryptotanshinone induces cell cycle arrest and apoptosis of multidrug resistant human chronic myeloid leukemia cells by inhibiting the activity of eukaryotic initiation factor 4E.Molecular and cellular biochemistry, , Volume: 368, Issue:1-2, 2012
Cryptotanshinone enhances TNF-α-induced apoptosis in chronic myeloid leukemia KBM-5 cells.Apoptosis : an international journal on programmed cell death, , Volume: 16, Issue:7, 2011
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Triptolide inhibits Bcr-Abl transcription and induces apoptosis in STI571-resistant chronic myelogenous leukemia cells harboring T315I mutation.Clinical cancer research : an official journal of the American Association for Cancer Research, , Mar-01, Volume: 15, Issue:5, 2009
Triptolide induces cell death independent of cellular responses to imatinib in blast crisis chronic myelogenous leukemia cells including quiescent CD34+ primitive progenitor cells.Molecular cancer therapeutics, , Volume: 8, Issue:9, 2009
Triptolide down-regulates bcr-abl expression and induces apoptosis in chronic myelogenous leukemia cells.Leukemia & lymphoma, , Volume: 45, Issue:2, 2004
Discovery of a novel water-soluble, rapid-release triptolide prodrug with improved drug-like properties and high efficacy in human acute myeloid leukemia.European journal of medicinal chemistry, , Dec-05, Volume: 243, 2022
Low-Dose Triptolide Enhanced Activity of Idarubicin Against Acute Myeloid Leukemia Stem-like Cells Via Inhibiting DNA Damage Repair Response.Stem cell reviews and reports, , Volume: 17, Issue:2, 2021
Low-dose triptolide enhances antitumor effect of JQ1 on acute myeloid leukemia through inhibiting RNA polymerase II in vitro and in vivo.Molecular carcinogenesis, , Volume: 59, Issue:9, 2020
Combining triptolide with ABT-199 is effective against acute myeloid leukemia through reciprocal regulation of Bcl-2 family proteins and activation of the intrinsic apoptotic pathway.Cell death & disease, , 07-22, Volume: 11, Issue:7, 2020
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[Effect of Low-Dose Triptolide and Sorafenib Alone and Their Combination on AML Cell Line MV411 and the Pathway of STAT5].Zhongguo shi yan xue ye xue za zhi, , Volume: 27, Issue:4, 2019
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[Study of growth inhibitory effect and apoptosis induced by different matches of Tanshinone IIA and Salvianolic Acid B on Acute Promyelocytic Leukemia cells (HL-60)].Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, , Volume: 31, Issue:10, 2008
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Triptolide inhibits proliferation of Epstein-Barr virus-positive B lymphocytes by down-regulating expression of a viral protein LMP1.Biochemical and biophysical research communications, , Jan-16, Volume: 456, Issue:3, 2015
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Malaria chemoprophylaxis with tafenoquine: a randomised study.Lancet (London, England), , Jun-10, Volume: 355, Issue:9220, 2000
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In vitro susceptibility of African isolates of Plasmodium falciparum from Gabon to pyronaridine.The American journal of tropical medicine and hygiene, , Volume: 60, Issue:1, 1999
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In vitro activity of artemether against African isolates (Senegal) of Plasmodium falciparum in comparison with standard antimalarial drugs.The American journal of tropical medicine and hygiene, , Volume: 58, Issue:3, 1998
Follow-up of the susceptibility of Plasmodium falciparum to antimalarials in Gabon.The American journal of tropical medicine and hygiene, , Volume: 58, Issue:5, 1998
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Halofantrine and primaquine for radical cure of malaria in Irian Jaya, Indonesia.Annals of tropical medicine and parasitology, , Volume: 91, Issue:1, 1997
Supportive pentoxifylline in falciparum malaria: no effect on tumor necrosis factor alpha levels or clinical outcome: a prospective, randomized, placebo-controlled study.The American journal of tropical medicine and hygiene, , Volume: 56, Issue:4, 1997
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Electrocardiographic changes and halofantrine plasma level during acute falciparum malaria.The American journal of tropical medicine and hygiene, , Volume: 54, Issue:3, 1996
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A randomised controlled trial to assess the relative efficacy of chloroquine, amodiaquine, halofantrine and Fansidar in the treatment of uncomplicated malaria in children.East African medical journal, , Volume: 73, Issue:3, 1996
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A case of dual chloroquine and halofantrine treatment failure in Zimbabwe.The Central African journal of medicine, , Volume: 41, Issue:10, 1995
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Activity of azithromycin as a blood schizonticide against rodent and human plasmodia in vivo.The American journal of tropical medicine and hygiene, , Volume: 52, Issue:2, 1995
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Comparison of micronized halofantrine with chloroquine-antibiotic combinations for treating Plasmodium falciparum malaria in adults from Gabon.The American journal of tropical medicine and hygiene, , Volume: 50, Issue:6, 1994
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[Malaria prophylaxis: recommendations adapted again].Nederlands tijdschrift voor geneeskunde, , Aug-20, Volume: 138, Issue:34, 1994
Comparison of capillary whole blood, venous whole blood, and plasma concentrations of mefloquine, halofantrine, and desbutyl-halofantrine measured by high-performance liquid chromatography.The American journal of tropical medicine and hygiene, , Volume: 51, Issue:6, 1994
Efficacy and tolerance of extended-dose halofantrine for drug-resistant falciparum malaria in Thailand.The American journal of tropical medicine and hygiene, , Volume: 50, Issue:2, 1994
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In vivo sensitivity of Plasmodium falciparum to halofantrine hydrochloride in Burkina Faso.The American journal of tropical medicine and hygiene, , Volume: 50, Issue:1, 1994
High dose chloroquine versus micronized halofantrine in chloroquine-resistant Plasmodium falciparum malaria.The Journal of antimicrobial chemotherapy, , Volume: 33, Issue:4, 1994
Falciparum malaria: differential effects of antimalarial drugs on ex vivo parasite viability during the critical early phase of therapy.The American journal of tropical medicine and hygiene, , Volume: 49, Issue:1, 1993
Clinical trials with halofantrine in acute uncomplicated falciparum malaria in Thailand.The Southeast Asian journal of tropical medicine and public health, , Volume: 24, Issue:1, 1993
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Halofantrine--an alternative treatment for malaria.Drug and therapeutics bulletin, , Jul-19, Volume: 31, Issue:15, 1993
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Halofantrine resistance in African countries.Lancet (London, England), , May-15, Volume: 341, Issue:8855, 1993
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LncRNA PlncRNA-1 accelerates the progression of prostate cancer by regulating PTEN/Akt axis.Aging, , 04-13, Volume: 13, Issue:8, 2021
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Triptolide delays disease progression in an adult rat model of polycystic kidney disease through the JAK2-STAT3 pathway.American journal of physiology. Renal physiology, , 09-01, Volume: 315, Issue:3, 2018
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PARP inhibition delays progression of mitochondrial encephalopathy in mice.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 11, Issue:3, 2014
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Triptolide inhibits the proliferation of prostate cancer cells and down-regulates SUMO-specific protease 1 expression.PloS one, , Volume: 7, Issue:5, 2012
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Triptolide, a diterpenoid triepoxide, suppresses inflammation and cartilage destruction in collagen-induced arthritis mice.Biochemical pharmacology, , Jan-01, Volume: 73, Issue:1, 2007
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Progressive interstitial renal fibrosis due to Chinese herbs in a patient with calcinosis Raynaud esophageal sclerodactyly telangiectasia (CREST) syndrome.Internal medicine (Tokyo, Japan), , Volume: 40, Issue:10, 2001
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A novel triptolide derivative ZT01 exerts anti-inflammatory effects by targeting TAK1 to prevent macrophage polarization into pro-inflammatory phenotype.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 126, 2020
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Sodium tanshinone IIA sulfonate attenuates cardiac dysfunction and improves survival of rats with cecal ligation and puncture-induced sepsis.Chinese journal of natural medicines, , Volume: 16, Issue:11, 2018
Sodium tanshinone II A sulfonate ameliorates microcirculatory disturbance of small intestine by attenuating the production of reactie oxygen species in rats with sepsis.Chinese journal of integrative medicine, , Volume: 22, Issue:10, 2016
Protective effect of sodium tanshinone IIA sulfonate on injury of small intestine in rats with sepsis and its mechanism.Chinese journal of integrative medicine, , Volume: 18, Issue:7, 2012
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Pneumonia-induced sepsis and gut injury: effects of a poly-(ADP-ribose) polymerase inhibitor.The Journal of surgical research, , Volume: 129, Issue:2, 2005
Decrease of the inflammatory response and induction of the Akt/protein kinase B pathway by poly-(ADP-ribose) polymerase 1 inhibitor in endotoxin-induced septic shock.Biochemical pharmacology, , Apr-15, Volume: 65, Issue:8, 2003
Sodium tanshinone IIA sulfonate improves inflammation, aortic endothelial cell apoptosis, disseminated intravascular coagulation and multiple organ damage in a rat heat stroke model.Molecular medicine reports, , Volume: 16, Issue:1, 2017
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Transcription factor NF-κB inhibitors as single therapeutic agents or in combination with classical chemotherapeutic agents for the treatment of hematologic malignancies.Current molecular pharmacology, , Volume: 3, Issue:3, 2010
Overcoming glucocorticoid resistance: a new pathway from an ancient Chinese medicine?Leukemia & lymphoma, , Volume: 50, Issue:5, 2009
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Sodium tanshinone IIA sulfonate improves cognitive impairment via regulating Aβ transportation in AD transgenic mouse model.Metabolic brain disease, , Volume: 37, Issue:4, 2022
PARP-DNA trapping ability of PARP inhibitors jeopardizes astrocyte viability: Implications for CNS disease therapeutics.Neuropharmacology, , 04-01, Volume: 187, 2021
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Increasing the TRPM2 Channel Expression in Human Neuroblastoma SH-SY5Y Cells Augments the Susceptibility to ROS-Induced Cell Death.Cells, , 01-08, Volume: 8, Issue:1, 2019
Triptolide Promotes the Clearance of α-Synuclein by Enhancing Autophagy in Neuronal Cells.Molecular neurobiology, , Volume: 54, Issue:3, 2017
[Advances in the study of immunopharmacological effects and mechanisms of extracts of Tripterygium wilfordii Hook. f. in neuroimmunologic disorders].Yao xue xue bao = Acta pharmaceutica Sinica, , Volume: 43, Issue:12, 2008
Inhibition by R(+) or S(-) pramipexole of caspase activation and cell death induced by methylpyridinium ion or beta amyloid peptide in SH-SY5Y neuroblastoma.Journal of neuroscience research, , Feb-15, Volume: 67, Issue:4, 2002
Dehydrojuncusol, a Natural Phenanthrene Compound Extracted from Journal of virology, , 05-15, Volume: 93, Issue:10, 2019
5-Oxo-1-[(2,3,6,7-tetramethoxy-9-phenanthrenyl)methyl]-L-proline Inhibits Hepatitis C Virus Entry.Scientific reports, , 05-13, Volume: 9, Issue:1, 2019
Tanshinone IIA inhibits smooth muscle proliferation and intimal hyperplasia in the rat carotid balloon-injured model through inhibition of MAPK signaling pathway.Journal of ethnopharmacology, , May-27, Volume: 129, Issue:2, 2010
[Experimental study of effect of tanshinone on artery restenosis in rat carotid injury model].Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, , Volume: 31, Issue:7, 2006
Attenuation of neointima formation through the inhibition of DNA repair enzyme PARP-1 in balloon-injured rat carotid artery.American journal of physiology. Heart and circulatory physiology, , Volume: 287, Issue:2, 2004
The crosstalk signals of Sodium Tanshinone ⅡA Sulfonate in rats with cerebral ischemic stroke: Insights from proteomics.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 151, 2022
Cryptotanshinone reduces neurotoxicity induced by cerebral ischemia-reperfusion injury involving modulation of microglial polarization.Restorative neurology and neuroscience, , Volume: 39, Issue:3, 2021
Sodium Tanshinone IIA Sulfonate Protects Against Cerebral Ischemia-reperfusion Injury by Inhibiting Autophagy and Inflammation.Neuroscience, , 08-10, Volume: 441, 2020
Improved Reperfusion and Vasculoprotection by the Poly(ADP-Ribose)Polymerase Inhibitor PJ34 After Stroke and Thrombolysis in Mice.Molecular neurobiology, , Volume: 55, Issue:12, 2018
Anti-Inflammatory and Neuroprotective Effects of Triptolide via the NF-κB Signaling Pathway in a Rat MCAO Model.Anatomical record (Hoboken, N.J. : 2007), , Volume: 299, Issue:2, 2016
TRPM4 inhibition promotes angiogenesis after ischemic stroke.Pflugers Archiv : European journal of physiology, , Volume: 466, Issue:3, 2014
Neuroprotection by the PARP inhibitor PJ34 modulates cerebral and circulating RAGE levels in rats exposed to focal brain ischemia.European journal of pharmacology, , Dec-05, Volume: 744, 2014
Activated microglia provide a neuroprotective role by balancing glial cell-line derived neurotrophic factor and tumor necrosis factor-α secretion after subacute cerebral ischemia.International journal of molecular medicine, , Volume: 31, Issue:1, 2013
Combined therapy with PJ34, a poly(ADP-ribose)polymerase inhibitor, reduces tissue plasminogen activator-induced hemorrhagic transformations in cerebral ischemia in mice.Fundamental & clinical pharmacology, , Volume: 27, Issue:4, 2013
The effects of Tanshinone IIA on blood-brain barrier and brain edema after transient middle cerebral artery occlusion in rats.Phytomedicine : international journal of phytotherapy and phytopharmacology, , Dec-01, Volume: 17, Issue:14, 2010
Neuroprotective effects of Tanshinone IIA on permanent focal cerebral ischemia in mice.Phytotherapy research : PTR, , Volume: 23, Issue:5, 2009
Role of P-glycoprotein in restricting the brain penetration of tanshinone IIA, a major active constituent from the root of Salvia miltiorrhiza Bunge, across the blood-brain barrier.Xenobiotica; the fate of foreign compounds in biological systems, , Volume: 37, Issue:6, 2007
Transport of cryptotanshinone, a major active triterpenoid in Salvia miltiorrhiza Bunge widely used in the treatment of stroke and Alzheimer's disease, across the blood-brain barrier.Current drug metabolism, , Volume: 8, Issue:4, 2007
Tanshinone IIB, a primary active constituent from Salvia miltiorrhza, exhibits neuro-protective activity in experimentally stroked rats.Neuroscience letters, , May-07, Volume: 417, Issue:3, 2007
Interaction between inducible nitric oxide synthase and poly(ADP-ribose) polymerase in focal ischemic brain injury.Stroke, , Volume: 35, Issue:12, 2004
[Influence of triptolide on neuronal apoptosis in rat with cerebral injury after focal ischemia reperfusion].Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, , Volume: 29, Issue:11, 2004
Protective effects of PJ34, a novel, potent inhibitor of poly(ADP-ribose) polymerase (PARP) in in vitro and in vivo models of stroke.International journal of molecular medicine, , Volume: 7, Issue:3, 2001
Sodium Tanshinone IIA Sulfonate Improves Adverse Ventricular Remodeling Post-MI by Reducing Myocardial Necrosis, Modulating Inflammation, and Promoting Angiogenesis.Current pharmaceutical design, , Volume: 28, Issue:9, 2022
Sodium tanshinone IIA sulfonate prevents the adverse left ventricular remodelling: Focus on polymorphonuclear neutrophil-derived granule components.Journal of cellular and molecular medicine, , Volume: 23, Issue:7, 2019
Effects of triptolide and methotrexate nanosuspensions on left ventricular remodeling in autoimmune myocarditis rats.International journal of nanomedicine, , Volume: 14, 2019
Triptolide attenuates pressure overload-induced myocardial remodeling in mice via the inhibition of NLRP3 inflammasome expression.Biochemical and biophysical research communications, , 03-25, Volume: 485, Issue:1, 2017
Triptolide alleviates isoprenaline-induced cardiac remodeling in rats via TGF-β1/Smad3 and p38 MAPK signaling pathway.Die Pharmazie, , Volume: 70, Issue:4, 2015
[Anti-inflammatory constituents, aloesin and aloemannan in Aloe species and effects of tanshinon VI in Salvia miltiorrhiza on heart].Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, , Volume: 123, Issue:7, 2003
Triptolide impairs thioredoxin system by suppressing Notch1-mediated PTEN/Akt/Txnip signaling in hepatocytes.Toxicology letters, , Volume: 300, 2019
Anticancer effect and neurotoxicity of S-(+)-deoxytylophorinidine, a new phenanthroindolizidine alkaloid that interacts with nucleic acids.Journal of Asian natural products research, , Volume: 13, Issue:5, 2011
Neuroprotective role of tripchlorolide on inflammatory neurotoxicity induced by lipopolysaccharide-activated microglia.Biochemical pharmacology, , Aug-01, Volume: 76, Issue:3, 2008
Transport of cryptotanshinone, a major active triterpenoid in Salvia miltiorrhiza Bunge widely used in the treatment of stroke and Alzheimer's disease, across the blood-brain barrier.Current drug metabolism, , Volume: 8, Issue:4, 2007
CYP1A induction and blue sac disease in early developmental stages of rainbow trout (Oncorhynchus Mykiss) exposed to retene.Journal of toxicology and environmental health. Part A, , Apr-11, Volume: 66, Issue:7, 2003
The crosstalk signals of Sodium Tanshinone ⅡA Sulfonate in rats with cerebral ischemic stroke: Insights from proteomics.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 151, 2022
Poly(ADP-Ribose) Polymerase Inhibitor PJ34 Reduces Brain Damage after Stroke in the Neonatal Mouse Brain.Current issues in molecular biology, , Jun-07, Volume: 43, Issue:1, 2021
Improved Reperfusion and Vasculoprotection by the Poly(ADP-Ribose)Polymerase Inhibitor PJ34 After Stroke and Thrombolysis in Mice.Molecular neurobiology, , Volume: 55, Issue:12, 2018
Sodium Tanshinone IIA Sulfonate Enhances Effectiveness Rt-PA Treatment in Acute Ischemic Stroke Patients Associated with Ameliorating Blood-Brain Barrier Damage.Translational stroke research, , Volume: 8, Issue:4, 2017
Cryptotanshinone exhibits therapeutical effects on cerebral stroke through the PI3K/AKT‑eNOS signaling pathway.Molecular medicine reports, , Volume: 16, Issue:6, 2017
Triptolide Protects Against Ischemic Stroke in Rats.Inflammation, , Volume: 38, Issue:4, 2015
Neuroprotection by the PARP inhibitor PJ34 modulates cerebral and circulating RAGE levels in rats exposed to focal brain ischemia.European journal of pharmacology, , Dec-05, Volume: 744, 2014
Another "string to the bow" of PJ34, a potent poly(ADP-Ribose)polymerase inhibitor: an antiplatelet effect through P2Y12 antagonism?PloS one, , Volume: 9, Issue:10, 2014
Prevention of rt-PA induced blood-brain barrier component degradation by the poly(ADP-ribose)polymerase inhibitor PJ34 after ischemic stroke in mice.Experimental neurology, , Volume: 248, 2013
The neuroprotective effects of Tanshinone IIA are associated with induced nuclear translocation of TORC1 and upregulated expression of TORC1, pCREB and BDNF in the acute stage of ischemic stroke.Brain research bulletin, , May-31, Volume: 82, Issue:3-4, 2010
Inhibition of poly(ADP-ribose) polymerase suppresses inflammation and promotes recovery after ischemic injury.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, , Volume: 29, Issue:4, 2009
Transport of cryptotanshinone, a major active triterpenoid in Salvia miltiorrhiza Bunge widely used in the treatment of stroke and Alzheimer's disease, across the blood-brain barrier.Current drug metabolism, , Volume: 8, Issue:4, 2007
Tanshinone IIB, a primary active constituent from Salvia miltiorrhza, exhibits neuro-protective activity in experimentally stroked rats.Neuroscience letters, , May-07, Volume: 417, Issue:3, 2007
Danshen: an overview of its chemistry, pharmacology, pharmacokinetics, and clinical use.Journal of clinical pharmacology, , Volume: 45, Issue:12, 2005
Protective effects of PJ34, a novel, potent inhibitor of poly(ADP-ribose) polymerase (PARP) in in vitro and in vivo models of stroke.International journal of molecular medicine, , Volume: 7, Issue:3, 2001
LLDT-67 attenuates MPTP-induced neurotoxicity in mice by up-regulating NGF expression.Acta pharmacologica Sinica, , Volume: 33, Issue:9, 2012
Triptolide protects against 1-methyl-4-phenyl pyridinium-induced dopaminergic neurotoxicity in rats: implication for immunosuppressive therapy in Parkinson's disease.Neuroscience bulletin, , Volume: 24, Issue:3, 2008
[Protective effects of triptolide on the lipopolysaccharide-mediated degeneration of dopaminergic neurons in substantia nigra].Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, , Volume: 26, Issue:8, 2006
Sequential delivery of nanoformulated α-mangostin and triptolide overcomes permeation obstacles and improves therapeutic effects in pancreatic cancer.Biomaterials, , Volume: 241, 2020
Inactivation of Cancer-Associated-Fibroblasts Disrupts Oncogenic Signaling in Pancreatic Cancer Cells and Promotes Its Regression.Cancer research, , 03-01, Volume: 78, Issue:5, 2018
Screening of Conditionally Reprogrammed Patient-Derived Carcinoma Cells Identifies ERCC3-MYC Interactions as a Target in Pancreatic Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research, , Dec-15, Volume: 22, Issue:24, 2016
Minnelide effectively eliminates CD133(+) side population in pancreatic cancer.Molecular cancer, , Nov-23, Volume: 14, 2015
Triptolide reverses hypoxia-induced epithelial-mesenchymal transition and stem-like features in pancreatic cancer by NF-κB downregulation.International journal of cancer, , May-15, Volume: 134, Issue:10, 2014
Establishment of hypoxia induction in an in vivo animal replacement model for experimental evaluation of pancreatic cancer.Oncology reports, , Volume: 32, Issue:1, 2014
Triptolide induces the expression of miR-142-3p: a negative regulator of heat shock protein 70 and pancreatic cancer cell proliferation.Molecular cancer therapeutics, , Volume: 12, Issue:7, 2013
Pancreas cancer meets the thunder god.Science translational medicine, , Oct-17, Volume: 4, Issue:156, 2012
Inhibition of C1-Ten PTPase activity reduces insulin resistance through IRS-1 and AMPK pathways.Scientific reports, , 12-19, Volume: 7, Issue:1, 2017
Urinary Biomarkers of Polycyclic Aromatic Hydrocarbons Are Associated with Cardiometabolic Health Risk.PloS one, , Volume: 10, Issue:9, 2015
(+)-Z-Bisdehydrodoisynolic acid ameliorates obesity and the metabolic syndrome in female ZDF rats.Obesity research, , Volume: 13, Issue:11, 2005
Triptolide impairs genome integrity by directly blocking the enzymatic activity of DNA-PKcs in human cells.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 129, 2020
SIRT6 rescues the age related decline in base excision repair in a PARP1-dependent manner.Cell cycle (Georgetown, Tex.), , Volume: 14, Issue:2, 2015
Poly(ADP-Ribosyl)ation Affects Histone Acetylation and Transcription.PloS one, , Volume: 10, Issue:12, 2015
Nature of bioavailability of DNA-intercalated polycyclic aromatic hydrocarbons to Sphingomonas sp.Chemosphere, , Volume: 80, Issue:8, 2010
Generation of free radicals in haemocytes of mussels after exposure to low molecular weight PAH components: immune activation, oxidative and genotoxic effects.Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, , Volume: 155, Issue:2, 2012
Aspects of the usefulness of five marine pollution biomarkers, with emphasis on MN and lipid content.Marine pollution bulletin, , Volume: 56, Issue:5, 2008
[Effects of chlorotriptolide and triptonide on chromosome aberration and micronuclei of bone marrow cell in male rats].Zhonghua nan ke xue = National journal of andrology, , Volume: 8, Issue:6, 2002
Network Pharmacology-Based Strategy Combined with Molecular Docking and in vitro Validation Study to Explore the Underlying Mechanism of Huo Luo Xiao Ling Dan in Treating Atherosclerosis.Drug design, development and therapy, , Volume: 16, 2022
Loss of PARP-1 attenuates diabetic arteriosclerotic calcification via Stat1/Runx2 axis.Cell death & disease, , 01-10, Volume: 11, Issue:1, 2020
PJ34, a PARP1 inhibitor, promotes endothelial repair in a rabbit model of high fat diet-induced atherosclerosis.Cell cycle (Georgetown, Tex.), , Volume: 18, Issue:17, 2019
Tanshinone IIA Sodium sulfonate regulates antioxidant system, inflammation, and endothelial dysfunction in atherosclerosis by downregulation of CLIC1.European journal of pharmacology, , Nov-15, Volume: 815, 2017
Cryptotanshinone inhibits TNF-α-induced early atherogenic events in vitro.The journal of physiological sciences : JPS, , Volume: 66, Issue:3, 2016
Miltirone protects human EA.hy926 endothelial cells from oxidized low-density lipoprotein-derived oxidative stress via a heme oxygenase-1 and MAPK/Nrf2 dependent pathway.Phytomedicine : international journal of phytotherapy and phytopharmacology, , Dec-15, Volume: 23, Issue:14, 2016
Cryptotanshinone, an orally bioactive herbal compound from Danshen, attenuates atherosclerosis in apolipoprotein E-deficient mice: role of lectin-like oxidized LDL receptor-1 (LOX-1).British journal of pharmacology, , Volume: 172, Issue:23, 2015
Tanshinone IIA attenuates atherosclerosis in ApoE(-/-) mice through down-regulation of scavenger receptor expression.European journal of pharmacology, , Jan-10, Volume: 650, Issue:1, 2011
Cryptotanshinone attenuates in vitro oxLDL-induced pre-lesional atherosclerotic events.Planta medica, , Volume: 77, Issue:16, 2011
Minocycline reduces plaque size in diet induced atherosclerosis via p27(Kip1).Atherosclerosis, , Volume: 219, Issue:1, 2011
PARP1 is required for adhesion molecule expression in atherogenesis.Cardiovascular research, , Apr-01, Volume: 78, Issue:1, 2008
Tanshinone IIA downregulates the CD40 expression and decreases MMP-2 activity on atherosclerosis induced by high fatty diet in rabbit.Journal of ethnopharmacology, , Jan-17, Volume: 115, Issue:2, 2008
Tanshinone II A attenuates atherosclerotic calcification in rat model by inhibition of oxidative stress.Vascular pharmacology, , Volume: 46, Issue:6, 2007
Design, synthesis, and structure-activity relationship of podocarpic acid amides as liver X receptor agonists for potential treatment of atherosclerosis.Bioorganic & medicinal chemistry letters, , Oct-15, Volume: 15, Issue:20, 2005
JAK2/STAT3/BMP-2 axis and NF-κB pathway are involved in erythropoietin-induced calcification in rat vascular smooth muscle cells.Clinical and experimental nephrology, , Volume: 23, Issue:4, 2019
Renoprotective effect of Tanshinone IIA, an active component of Salvia miltiorrhiza, on rats with chronic kidney disease.Phytotherapy research : PTR, , Volume: 24, Issue:12, 2010
Key role of organic cation transporter 2 for the nephrotoxicity effect of triptolide in rheumatoid arthritis.International immunopharmacology, , Volume: 77, 2019
Is "Chinese herbs nephropathy" a prejudicial term?American journal of kidney diseases : the official journal of the National Kidney Foundation, , Volume: 38, Issue:5, 2001
Aristolochic acid nephropathy in a Chinese patient: time to abandon the term "Chinese herbs nephropathy"?American journal of kidney diseases : the official journal of the National Kidney Foundation, , Volume: 38, Issue:5, 2001
Analyses of DNA adducts formed by ochratoxin A and aristolochic acid in patients with Chinese herbs nephropathy.Mutation research, , Jul-25, Volume: 494, Issue:1-2, 2001
Effects of steroids on the progression of renal failure in chronic interstitial renal fibrosis: a pilot study in Chinese herbs nephropathy.American journal of kidney diseases : the official journal of the National Kidney Foundation, , Volume: 27, Issue:2, 1996
Anticancer activity of cryptotanshinone on acute lymphoblastic leukemia cells.Archives of toxicology, , Volume: 90, Issue:9, 2016
Low dose triptolide reverses chemoresistance in adult acute lymphoblastic leukemia cells via reactive oxygen species generation and DNA damage response disruption.Oncotarget, , Dec-20, Volume: 7, Issue:51, 2016
Cryptotanshinone deregulates unfolded protein response and eukaryotic initiation factor signaling in acute lymphoblastic leukemia cells.Phytomedicine : international journal of phytotherapy and phytopharmacology, , Feb-15, Volume: 23, Issue:2, 2016
Miltirone Induces G2/M Cell Cycle Arrest and Apoptosis in CCRF-CEM Acute Lymphoblastic Leukemia Cells.Journal of natural products, , Jun-26, Volume: 78, Issue:6, 2015
Triptolide inhibits MDM2 and induces apoptosis in acute lymphoblastic leukemia cells through a p53-independent pathway.Molecular cancer therapeutics, , Volume: 12, Issue:2, 2013
CDA: combinatorial drug discovery using transcriptional response modules.PloS one, , Volume: 7, Issue:8, 2012
Nitric oxide is synthesized in acute leukemia cells after exposure to phenolic antioxidants and initially protects against mitochondrial membrane depolarization.Cancer letters, , Nov-08, Volume: 215, Issue:1, 2004
Armepavine oxalate induces cell death on CCRF-CEM leukemia cell line through an apoptotic pathway.Life sciences, , Jun-18, Volume: 75, Issue:5, 2004
Dihydrotanshinone Attenuates LPS-Induced Acute Lung Injury in Mice by Upregulating LXRα.Inflammation, , Volume: 45, Issue:1, 2022
Development and assessment of countermeasure formulations for treatment of lung injury induced by chlorine inhalation.Toxicology and applied pharmacology, , May-01, Volume: 298, 2016
Effect of triptolide on the regulation of ATP‑binding cassette transporter A1 expression in lipopolysaccharide‑induced acute lung injury of rats.Molecular medicine reports, , Volume: 10, Issue:6, 2014
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Combination treatment with triptolide and hydroxycamptothecin synergistically enhances apoptosis in A549 lung adenocarcinoma cells through PP2A-regulated ERK, p38 MAPKs and Akt signaling pathways.International journal of oncology, , Volume: 46, Issue:3, 2015
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Triptolide decreases rheumatoid arthritis fibroblast-like synoviocyte proliferation, invasion, inflammation and presents a therapeutic effect in collagen-induced arthritis rats via inactivating lncRNA RP11-83J16.1 mediated URI1 and β-catenin signaling.International immunopharmacology, , Volume: 99, 2021
Acupoint nanocomposite hydrogel for simulation of acupuncture and targeted delivery of triptolide against rheumatoid arthritis.Journal of nanobiotechnology, , Dec-07, Volume: 19, Issue:1, 2021
Construction of a pH-responsive, ultralow-dose triptolide nanomedicine for safe rheumatoid arthritis therapy.Acta biomaterialia, , Volume: 121, 2021
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The Study of Cellular Mechanism of Triptolide in the Treatment of Cancer, Bone Loss and Cardiovascular Disease and Triptolide's Toxicity.Current stem cell research & therapy, , Volume: 15, Issue:1, 2020
Tylophorine-based compounds are therapeutic in rheumatoid arthritis by targeting the caprin-1 ribonucleoprotein complex and inhibiting expression of associated c-Myc and HIF-1α.Pharmacological research, , Volume: 152, 2020
Prediction of triptolide targets in rheumatoid arthritis using network pharmacology and molecular docking.International immunopharmacology, , Volume: 80, 2020
Transdermal drug delivery of triptolide-loaded nanostructured lipid carriers: Preparation, pharmacokinetic, and evaluation for rheumatoid arthritis.International journal of pharmaceutics, , Jan-10, Volume: 554, 2019
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The triptolide-induced apoptosis of osteoclast precursor by degradation of cIAP2 and treatment of rheumatoid arthritis of TNF-transgenic mice.Phytotherapy research : PTR, , Volume: 33, Issue:2, 2019
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Triptolide inhibits the inflammatory activities of neutrophils to ameliorate chronic arthritis.Molecular immunology, , Volume: 101, 2018
Study on the efficacy and mechanism of triptolide on treating TNF transgenic mice with rheumatoid arthritis.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 106, 2018
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Sodium tanshinone IIA sulfonate inhibits hypoxia-induced enhancement of SOCE in pulmonary arterial smooth muscle cells via the PKG-PPAR-γ signaling axis.American journal of physiology. Cell physiology, , 07-01, Volume: 311, Issue:1, 2016
Triptolide Improves Diabetic Nephropathy by Regulating Th Cell Balance and Macrophage Infiltration in Rat Models of Diabetic Nephropathy.Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, , Volume: 124, Issue:6, 2016
Microglial activation induced by the alarmin S100B is regulated by poly(ADP-ribose) polymerase-1.Glia, , Volume: 64, Issue:11, 2016
Anti-Inflammatory and Neuroprotective Effects of Triptolide via the NF-κB Signaling Pathway in a Rat MCAO Model.Anatomical record (Hoboken, N.J. : 2007), , Volume: 299, Issue:2, 2016
Therapeutic effect of dioscin on collagen-induced arthritis through reduction of Th1/Th2.International immunopharmacology, , Volume: 39, 2016
Cryptotanshinone protects against adriamycin-induced mitochondrial dysfunction in cardiomyocytes.Pharmaceutical biology, , Volume: 54, Issue:2, 2016
Frataxin Deficiency Promotes Excess Microglial DNA Damage and Inflammation that Is Rescued by PJ34.PloS one, , Volume: 11, Issue:3, 2016
Triptolide Attenuates Myocardial Ischemia/Reperfusion Injuries in Rats by Inducing the Activation of Nrf2/HO-1 Defense Pathway.Cardiovascular toxicology, , Volume: 16, Issue:4, 2016
Antidepressant effects of TBE-31 and MCE-1, the novel Nrf2 activators, in an inflammation model of depression.European journal of pharmacology, , Dec-15, Volume: 793, 2016
Triptolide Attenuates Inflammatory Response in Membranous Glomerulo-Nephritis Rat via Downregulation of NF-κB Signaling Pathway.Kidney & blood pressure research, , Volume: 41, Issue:6, 2016
A novel selective prostaglandin E2 synthesis inhibitor relieves pyrexia and arthritis in Guinea pigs inflammatory models.Journal of pharmacological sciences, , Volume: 130, Issue:2, 2016
PARP inhibition attenuates early brain injury through NF-κB/MMP-9 pathway in a rat model of subarachnoid hemorrhage.Brain research, , 08-01, Volume: 1644, 2016
Effect of sodium tanshinone IIA sulfonate treatment in a rat model of preeclampsia.American journal of physiology. Regulatory, integrative and comparative physiology, , Feb-01, Volume: 308, Issue:3, 2015
Protective effects of triptolide on retinal ganglion cells in a rat model of chronic glaucoma.Drug design, development and therapy, , Volume: 9, 2015
Improvement of spatial learning by facilitating large-conductance calcium-activated potassium channel with transcranial magnetic stimulation in Alzheimer's disease model mice.Neuropharmacology, , Volume: 97, 2015
Cryptotanshinone inhibits breast cancer cell growth by suppressing estrogen receptor signaling.Cancer biology & therapy, , Volume: 16, Issue:1, 2015
Sodium tanshinone IIA sulfonate ameliorates experimental coronary no-reflow phenomenon through down-regulation of FGL2.Life sciences, , Dec-01, Volume: 142, 2015
Anti-inflammatory effects of triptolide on IgA nephropathy in rats.Immunopharmacology and immunotoxicology, , Volume: 37, Issue:5, 2015
Targeting lipid peroxidation and mitochondrial imbalance in Friedreich's ataxia.Pharmacological research, , Volume: 99, 2015
Triptolide (TPL) improves locomotor function recovery in rats and reduces inflammation after spinal cord injury.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, , Volume: 36, Issue:5, 2015
A novel NAD(P)H-dependent carbonyl reductase specifically expressed in the thyroidectomized chicken fatty liver: catalytic properties and crystal structure.The FEBS journal, , Volume: 282, Issue:20, 2015
Sodium tanshinone IIA sulfonate ameliorates ischemia-induced myocardial inflammation and lipid accumulation in Beagle dogs through NLRP3 inflammasome.International journal of cardiology, , Oct-01, Volume: 196, 2015
Targeted delivery of NK007 to macrophages to treat colitis.Journal of pharmaceutical sciences, , Volume: 104, Issue:7, 2015
Cognitive recovery by chronic activation of the large-conductance calcium-activated potassium channel in a mouse model of Alzheimer's disease.Neuropharmacology, , Volume: 92, 2015
Protective actions of PJ34, a poly(ADP-ribose)polymerase inhibitor, on the blood-brain barrier after traumatic brain injury in mice.Neuroscience, , Apr-16, Volume: 291, 2015
Triptolide suppresses airway goblet cell hyperplasia and Muc5ac expression via NF-κB in a murine model of asthma.Molecular immunology, , Volume: 64, Issue:1, 2015
The potential of follicle-stimulating hormone peptide-modified triptolide-loaded nanoparticles to induce a mouse model of premature ovarian insufficiency.International journal of nanomedicine, , Volume: 10, 2015
Triptolide preserves cognitive function and reduces neuropathology in a mouse model of Alzheimer's disease.PloS one, , Volume: 9, Issue:9, 2014
Triptolide synergistically enhances temozolomide-induced apoptosis and potentiates inhibition of NF-κB signaling in glioma initiating cells.The American journal of Chinese medicine, , Volume: 42, Issue:2, 2014
Triptolide synergistically enhances antitumor activity of oxaliplatin in colon carcinoma in vitro and in vivo.DNA and cell biology, , Volume: 33, Issue:7, 2014
MCL1 and BCL-xL levels in solid tumors are predictive of dinaciclib-induced apoptosis.PloS one, , Volume: 9, Issue:10, 2014
Anti-inflammatory effects of triptolide by inhibiting the NF-κB signalling pathway in LPS-induced acute lung injury in a murine model.Molecular medicine reports, , Volume: 10, Issue:1, 2014
Triptolide treatment reduces Alzheimer's disease (AD)-like pathology through inhibition of BACE1 in a transgenic mouse model of AD.Disease models & mechanisms, , Volume: 7, Issue:12, 2014
Evidence for involvement of spinal RANTES in the antinociceptive effects of triptolide, a diterpene triepoxide, in a rat model of bone cancer pain.Basic & clinical pharmacology & toxicology, , Volume: 115, Issue:6, 2014
Effects of triptolide on degeneration of dendritic spines induced by Aβ1-40 injection in rat hippocampus.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, , Volume: 35, Issue:1, 2014
NAD(+)-dependent activation of Sirt1 corrects the phenotype in a mouse model of mitochondrial disease.Cell metabolism, , Jun-03, Volume: 19, Issue:6, 2014
Triptolide attenuates acute small-for-size liver graft injury in rats by inhibition of Toll-like receptor 4.Transplantation proceedings, , Volume: 46, Issue:10, 2014
PARP-1 inhibition attenuates neuronal loss, microglia activation and neurological deficits after traumatic brain injury.Journal of neurotrauma, , Apr-15, Volume: 31, Issue:8, 2014
CD133+ tumor initiating cells in a syngenic murine model of pancreatic cancer respond to Minnelide.Clinical cancer research : an official journal of the American Association for Cancer Research, , May-01, Volume: 20, Issue:9, 2014
Cryptotanshinone reverses ovarian insulin resistance in mice through activation of insulin signaling and the regulation of glucose transporters and hormone synthesizing enzymes.Fertility and sterility, , Volume: 102, Issue:2, 2014
Cryptotanshinone inhibits lung tumorigenesis and induces apoptosis in cancer cells in vitro and in vivo.Molecular medicine reports, , Volume: 9, Issue:6, 2014
Anti-inflammatory effects of triptolide improve left ventricular function in a rat model of diabetic cardiomyopathy.Cardiovascular diabetology, , Mar-25, Volume: 12, 2013
Effect of ketoconazole, a cytochrome P450 inhibitor, on the efficacy of quinine and halofantrine against Schistosoma mansoni in mice.The Korean journal of parasitology, , Volume: 51, Issue:2, 2013
Improved retinal ganglion cell survival through retinal microglia suppression by a chinese herb extract, triptolide, in the DBA/2J mouse model of glaucoma.Ocular immunology and inflammation, , Volume: 21, Issue:5, 2013
Prevention of rt-PA induced blood-brain barrier component degradation by the poly(ADP-ribose)polymerase inhibitor PJ34 after ischemic stroke in mice.Experimental neurology, , Volume: 248, 2013
Activated microglia provide a neuroprotective role by balancing glial cell-line derived neurotrophic factor and tumor necrosis factor-α secretion after subacute cerebral ischemia.International journal of molecular medicine, , Volume: 31, Issue:1, 2013
Tylophorine, a phenanthraindolizidine alkaloid isolated from Tylophora indica exerts antiangiogenic and antitumor activity by targeting vascular endothelial growth factor receptor 2-mediated angiogenesis.Molecular cancer, , Jul-29, Volume: 12, 2013
A novel tylophorine analog W-8 up-regulates forkhead boxP3 expression and ameliorates murine colitis.Journal of leukocyte biology, , Volume: 93, Issue:1, 2013
Implication of the TRPM4 nonselective cation channel in mammalian sinus rhythm.Heart rhythm, , Volume: 10, Issue:11, 2013
Regulation of antioxidant system, lipids and fatty acid β-oxidation contributes to the cardioprotective effect of sodium tanshinone IIA sulphonate in isoproterenol-induced myocardial infarction in rats.Atherosclerosis, , Volume: 230, Issue:1, 2013
Triptolide downregulates Treg cells and the level of IL-10, TGF-β, and VEGF in melanoma-bearing mice.Planta medica, , Volume: 79, Issue:15, 2013
Sodium tanshinone IIA sulfonate protects rat myocardium against ischemia-reperfusion injury via activation of PI3K/Akt/FOXO3A/Bim pathway.Acta pharmacologica Sinica, , Volume: 34, Issue:11, 2013
Administration of poly(ADP-ribose) polymerase inhibitor into bronchial artery attenuates pulmonary pathophysiology after smoke inhalation and burn in an ovine model.Burns : journal of the International Society for Burn Injuries, , Volume: 38, Issue:8, 2012
NF-κB inhibition significantly upregulates the norepinephrine transporter system, causes apoptosis in pheochromocytoma cell lines and prevents metastasis in an animal model.International journal of cancer, , Nov-15, Volume: 131, Issue:10, 2012
Poly(ADP-ribose) polymerase 1 activation is required for cisplatin nephrotoxicity.Kidney international, , Volume: 82, Issue:2, 2012
Contribution of PARP to endothelial dysfunction and hypertension in a rat model of pre-eclampsia.British journal of pharmacology, , Volume: 166, Issue:7, 2012
LLDT-67 attenuates MPTP-induced neurotoxicity in mice by up-regulating NGF expression.Acta pharmacologica Sinica, , Volume: 33, Issue:9, 2012
Effects of triptolide on the synaptophysin expression of hippocampal neurons in the AD cellular model.International immunopharmacology, , Volume: 13, Issue:2, 2012
TRAIL induces necroptosis involving RIPK1/RIPK3-dependent PARP-1 activation.Cell death and differentiation, , Volume: 19, Issue:12, 2012
Anti-inflammatory and neuroprotective effects of triptolide on traumatic brain injury in rats.Respiratory physiology & neurobiology, , Jun-15, Volume: 182, Issue:1, 2012
Spinal cannabinoid receptor type 2 agonist reduces mechanical allodynia and induces mitogen-activated protein kinase phosphatases in a rat model of neuropathic pain.The journal of pain, , Volume: 13, Issue:9, 2012
MRx102, a triptolide derivative, has potent antileukemic activity in vitro and in a murine model of AML.Leukemia, , Volume: 26, Issue:3, 2012
Triptolide increases transcript and protein levels of survival motor neurons in human SMA fibroblasts and improves survival in SMA-like mice.British journal of pharmacology, , Volume: 166, Issue:3, 2012
The effects of triptolide on airway remodelling and transforming growth factor-β₁/Smad signalling pathway in ovalbumin-sensitized mice.Immunology, , Volume: 132, Issue:3, 2011
Triptolide protects mice from ischemia/reperfusion injury by inhibition of IL-17 production.International immunopharmacology, , Volume: 11, Issue:10, 2011
Dual, constrictor-to-dilator, response of the mouse ductus arteriosus to the microsomal prostaglandin E synthase-1 inhibitor, 2-(6-chloro-1H-phenanthro[9,10d]imidazole- 2-yl)isophthalonitrile.Neonatology, , Volume: 100, Issue:2, 2011
Sac-0601 prevents retinal vascular leakage in a mouse model of diabetic retinopathy.European journal of pharmacology, , Apr-25, Volume: 657, Issue:1-3, 2011
Anti-inflammatory activities of Taxusabietane A isolated from Taxus wallichiana Zucc.Fitoterapia, , Volume: 82, Issue:7, 2011
Effectiveness of triptolide-coated stent on decreasing inflammation and attenuation of intimal hyperplasia in a pig after coronary angioplasty.Angiology, , Volume: 62, Issue:3, 2011
[Neuroprotective effects of tanshinone II A on vascular dementia in rats].Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, , Volume: 35, Issue:14, 2010
Renoprotective effect of Tanshinone IIA, an active component of Salvia miltiorrhiza, on rats with chronic kidney disease.Phytotherapy research : PTR, , Volume: 24, Issue:12, 2010
Triptolide promotes spinal cord repair by inhibiting astrogliosis and inflammation.Glia, , Volume: 58, Issue:8, 2010
Triptolide reduces cyst formation in a neonatal to adult transition Pkd1 model of ADPKD.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, , Volume: 25, Issue:7, 2010
Postischemic poly (ADP-ribose) polymerase (PARP) inhibition reduces ischemia reperfusion injury in a hind-limb ischemia model.Surgery, , Volume: 148, Issue:1, 2010
Preparation and anti-inflammatory activity of triptolide ethosomes in an erythema model.Journal of liposome research, , Volume: 20, Issue:4, 2010
[Effect of tanshitone on prevention and treatment of retinoic acid induced osteoporosis in mice].Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, , Volume: 35, Issue:21, 2010
Tanshinone II A attenuates inflammatory responses of rats with myocardial infarction by reducing MCP-1 expression.Phytomedicine : international journal of phytotherapy and phytopharmacology, , Volume: 17, Issue:3-4, 2010
Triptolide prolonged allogeneic islet graft survival in chemically induced and spontaneously diabetic mice without impairment of islet function.Hepatobiliary & pancreatic diseases international : HBPD INT, , Volume: 9, Issue:3, 2010
Triptolide reduces proteinuria in experimental membranous nephropathy and protects against C5b-9-induced podocyte injury in vitro.Kidney international, , Volume: 77, Issue:11, 2010
Z-Bisdehydrodoisynolic acid (Z-BDDA): an estrogenic seco-steroid that enhances behavioral recovery following moderate fluid percussion brain injury in male rats.Brain research, , Nov-29, Volume: 1362, 2010
Antiangiogenic activity of Tripterygium wilfordii and its terpenoids.Journal of ethnopharmacology, , Jan-12, Volume: 121, Issue:1, 2009
Oral administration of triptolide ameliorates the clinical signs of experimental autoimmune encephalomyelitis (EAE) by induction of HSP70 and stabilization of NF-kappaB/IkappaBalpha transcriptional complex.Journal of neuroimmunology, , Dec-10, Volume: 217, Issue:1-2, 2009
Discovery of disubstituted phenanthrene imidazoles as potent, selective and orally active mPGES-1 inhibitors.Bioorganic & medicinal chemistry letters, , Oct-15, Volume: 19, Issue:20, 2009
Cryptotanshinone, a compound from Salvia miltiorrhiza modulates amyloid precursor protein metabolism and attenuates beta-amyloid deposition through upregulating alpha-secretase in vivo and in vitro.Neuroscience letters, , Mar-13, Volume: 452, Issue:2, 2009
Triptolide exerts anti-tumor effect on oral cancer and KB cells in vitro and in vivo.Oral oncology, , Volume: 45, Issue:7, 2009
Therapeutic effects of triptolide on interleukin-10 gene-deficient mice with colitis.International immunopharmacology, , Dec-20, Volume: 8, Issue:13-14, 2008
Effective therapy for nephritis in (NZB x NZW)F1 mice with triptolide and tripdiolide, the principal active components of the Chinese herbal remedy Tripterygium wilfordii Hook F.Arthritis and rheumatism, , Volume: 58, Issue:6, 2008
[Effect of tanshinone II A on angiotensin receptor in hypertrophic myocardium of rats with pressure over-loading].Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, , Volume: 28, Issue:7, 2008
Inhibition of prostaglandin and nitric oxide production in lipopolysaccharide-treated RAW 264.7 cells by tanshinones from the roots of Salvia miltiorrhiza bunge.Archives of pharmacal research, , Volume: 31, Issue:6, 2008
Tanshinone IIA suppresses inflammatory bone loss by inhibiting the synthesis of prostaglandin E2 in osteoblasts.European journal of pharmacology, , Dec-28, Volume: 601, Issue:1-3, 2008
Effect of tanshinone on the levels of nitric oxide synthase and acetylcholinesterase in the brain of Alzheimer's disease rat model.Clinical and investigative medicine. Medecine clinique et experimentale, , Oct-01, Volume: 31, Issue:5, 2008
PARP1 is required for adhesion molecule expression in atherogenesis.Cardiovascular research, , Apr-01, Volume: 78, Issue:1, 2008
Tanshinone IIA down-regulates the protein expression of ErbB-2 and up-regulates TNF-alpha in colon cancer cells in vitro and in vivo.International journal of molecular medicine, , Volume: 22, Issue:6, 2008
[Effects of cryptotanshinone in lowering androgens synthesis for the prenatally androgenized male rats].Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, , Volume: 28, Issue:11, 2008
Tanshinone IIA downregulates the CD40 expression and decreases MMP-2 activity on atherosclerosis induced by high fatty diet in rabbit.Journal of ethnopharmacology, , Jan-17, Volume: 115, Issue:2, 2008
Age, gender, and hormonal status modulate the vascular toxicity of the diesel exhaust extract phenanthraquinone.Journal of toxicology and environmental health. Part A, , Volume: 71, Issue:7, 2008
Tanshinone IIB, a primary active constituent from Salvia miltiorrhza, exhibits neuro-protective activity in experimentally stroked rats.Neuroscience letters, , May-07, Volume: 417, Issue:3, 2007
Transport of cryptotanshinone, a major active triterpenoid in Salvia miltiorrhiza Bunge widely used in the treatment of stroke and Alzheimer's disease, across the blood-brain barrier.Current drug metabolism, , Volume: 8, Issue:4, 2007
Experimental AA amyloidosis in mice is inhibited by treatment with triptolide, a purified traditional Chinese medicine.International immunopharmacology, , Volume: 7, Issue:9, 2007
Tanshinone II A attenuates atherosclerotic calcification in rat model by inhibition of oxidative stress.Vascular pharmacology, , Volume: 46, Issue:6, 2007
Cardiotoxicity reduction induced by halofantrine entrapped in nanocapsule devices.Life sciences, , Mar-13, Volume: 80, Issue:14, 2007
Substituted phenanthrene imidazoles as potent, selective, and orally active mPGES-1 inhibitors.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 17, Issue:24, 2007
[The inhibitive effect of sodium tanshinone II A sulfonic acid on intimal hyperplasia in rabbit iliac artery ballon injury model].Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, , Volume: 30, Issue:7, 2007
Abrogation of skin disease in LUPUS-prone MRL/FASlpr mice by means of a novel tylophorine analog.Arthritis and rheumatism, , Volume: 54, Issue:10, 2006
Poly adenosine diphosphate-ribose polymerase inhibitor PJ34 abolishes systemic proinflammatory responses to thoracic aortic ischemia and reperfusion.Journal of the American College of Surgeons, , Volume: 203, Issue:1, 2006
I.c.v. administration of the nonsteroidal glucocorticoid receptor antagonist, CP-472555, prevents exacerbated hypoglycemia during repeated insulin administration.Neuroscience, , Jun-30, Volume: 140, Issue:2, 2006
Beneficial effects of PJ34 and INO-1001, two novel water-soluble poly(ADP-ribose) polymerase inhibitors, on the consequences of traumatic brain injury in rat.Brain research, , Apr-18, Volume: 1041, Issue:2, 2005
Poly(ADP-ribose) polymerase inhibitor PJ-34 reduces mesenteric vascular injury induced by experimental cardiopulmonary bypass with cardiac arrest.American journal of physiology. Heart and circulatory physiology, , Volume: 288, Issue:6, 2005
[Inhibitive effect to collagen fiber of tanshinone II A in iliac artery following balloon injury in rabbit].Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, , Volume: 28, Issue:10, 2005
Protection effect of triptolide to liver injury in rats with severe acute pancreatitis.Hepatobiliary & pancreatic diseases international : HBPD INT, , Volume: 4, Issue:4, 2005
(+)-Z-Bisdehydrodoisynolic acid ameliorates obesity and the metabolic syndrome in female ZDF rats.Obesity research, , Volume: 13, Issue:11, 2005
The therapeutic effects of PJ34 [N-(6-oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide.HCl], a selective inhibitor of poly(ADP-ribose) polymerase, in experimental allergic encephalomyelitis are associated with immunomodulation.The Journal of pharmacology and experimental therapeutics, , Volume: 310, Issue:3, 2004
Interaction between inducible nitric oxide synthase and poly(ADP-ribose) polymerase in focal ischemic brain injury.Stroke, , Volume: 35, Issue:12, 2004
CYP1A induction and blue sac disease in early developmental stages of rainbow trout (Oncorhynchus Mykiss) exposed to retene.Journal of toxicology and environmental health. Part A, , Apr-11, Volume: 66, Issue:7, 2003
Effect of a chemical mixture on dermal penetration of arsenic and nickel in male pig in vitro.Journal of toxicology and environmental health. Part A, , Apr-11, Volume: 66, Issue:7, 2003
Systemic and hepatosplanchnic hemodynamic and metabolic effects of the PARP inhibitor PJ34 during hyperdynamic porcine endotoxemia.Shock (Augusta, Ga.), , Volume: 19, Issue:5, 2003
Role of the activation of the nuclear enzyme poly(ADP-ribose) polymerase in the pathogenesis of periodontitis.Journal of dental research, , Volume: 82, Issue:12, 2003
The suppressive effect of triptolide on experimental autoimmune uveoretinitis by down-regulating Th1-type response.International immunopharmacology, , Volume: 3, Issue:10-11, 2003
Structure-activity relationships in allergic contact dermatitis. Part III. The sensitizing capacity of substituted phenanthrenequinones: a quantum-mechanical approach.American journal of contact dermatitis : official journal of the American Contact Dermatitis Society, , Volume: 14, Issue:2, 2003
Novel isoquinolinone-derived inhibitors of poly(ADP-ribose) polymerase-1: pharmacological characterization and neuroprotective effects in an in vitro model of cerebral ischemia.The Journal of pharmacology and experimental therapeutics, , Volume: 305, Issue:3, 2003
Role of poly(ADP-ribose) polymerase activation in endotoxin-induced cardiac collapse in rodents.Biochemical pharmacology, , Dec-15, Volume: 64, Issue:12, 2002
Protective effect of a novel, potent inhibitor of poly(adenosine 5'-diphosphate-ribose) synthetase in a porcine model of severe bacterial sepsis.Critical care medicine, , Volume: 30, Issue:5, 2002
Proarrhythmic potential of halofantrine, terfenadine and clofilium in a modified in vivo model of torsade de pointes.British journal of pharmacology, , Volume: 135, Issue:4, 2002
Protective effect of carnosol on CCl(4)-induced acute liver damage in rats.European journal of gastroenterology & hepatology, , Volume: 14, Issue:9, 2002
[The effect of triptolide on the expression of BCL-2, ICE in pulmonary tissue of asthmatic guinea pig].Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology, , Volume: 17, Issue:3, 2001
Chronic aristolochic acid toxicity in rabbits: a model of Chinese herbs nephropathy?Kidney international, , Volume: 59, Issue:6, 2001
Cancer chemopreventive activities of S-3-1, a synthetic derivative of danshinone.Journal of Asian natural products research, , Volume: 3, Issue:1, 2001
Protective effects of PJ34, a novel, potent inhibitor of poly(ADP-ribose) polymerase (PARP) in in vitro and in vivo models of stroke.International journal of molecular medicine, , Volume: 7, Issue:3, 2001
[Establishment of model of aristolochic acid-induced chronic renal interstitial fibrosis in rats].Zhonghua yi xue za zhi, , Sep-25, Volume: 81, Issue:18, 2001
Inhibition of cellular immune responses by Tylophora indica in experimental models.Phytomedicine : international journal of phytotherapy and phytopharmacology, , Volume: 8, Issue:5, 2001
Triptolide attenuates pulmonary arterial hypertension and neointimal formation in rats.American journal of respiratory and critical care medicine, , Volume: 162, Issue:6, 2000
Modulation of halofantrine resistance after coadministration of halofantrine with diverse pharmacological agents in a rodent malaria model.Life sciences, , Aug-04, Volume: 67, Issue:11, 2000
Mechanism of cardiotoxicity of halofantrine.Clinical pharmacology and therapeutics, , Volume: 67, Issue:5, 2000
Activity of azithromycin as a blood schizonticide against rodent and human plasmodia in vivo.The American journal of tropical medicine and hygiene, , Volume: 52, Issue:2, 1995
Effect of nonapeptide fragments of uteroglobin and lipocortin I on oedema and mast cell degranulation.European journal of pharmacology, , Nov-03, Volume: 264, Issue:3, 1994
Plasmodium falciparum and Plasmodium vivax infections in the owl monkey (Aotus trivirgatus). III. Methods employed in the search for new blood schizonticidal drugs.The American journal of tropical medicine and hygiene, , Volume: 27, Issue:4, 1978
Evaluating new antimalarial drugs against trophozoite induced Plasmodium cynomolgi malaria in rhesus monkeys.The American journal of tropical medicine and hygiene, , Volume: 25, Issue:1, 1976
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[The induction of nonspecific resistance by lysozyme and aristolochia acid in bacterial and viral infections].Zentralblatt fur Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. 1. Abt. Medizinisch-hygienische Bakteriologie, Virusforschung und Parasitologie. Originale, , Volume: 213, Issue:3, 1970
Triptolide prevents and attenuates neuropathic pain via inhibiting central immune response.Pain physician, , Volume: 15, Issue:6
Sodium Tanshinone IIA Sulfonate Attenuates Tumor Oxidative Stress and Promotes Apoptosis in an Intermittent Hypoxia Mouse Model.Technology in cancer research & treatment, , Volume: 19
The synergistic effect of treatment with triptolide and MK-801 in the rat neuropathic pain model.Molecular pain, , Volume: 13
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Longitudinal study of [D10]phenanthrene metabolism by the diol epoxide pathway in smokers.Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, , Volume: 18, Issue:2, 2013
Metabolism of [D10]phenanthrene to tetraols in smokers for potential lung cancer susceptibility assessment: comparison of oral and inhalation routes of administration.The Journal of pharmacology and experimental therapeutics, , Volume: 338, Issue:1, 2011
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In vivo evaluation of the safety of triptolide-loaded hydrogel-thickened microemulsion.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, , Volume: 46, Issue:12, 2008
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[4 cases of recurring pseudo-scarlet fever due to the use of phenanthrene alkaloids with a 6-hydroxy group (codeine and morphine)].Nederlands tijdschrift voor geneeskunde, , Apr-30, Volume: 121, Issue:18, 1977
Comparison of a 9-phenanthrene methanol (WR33063), a 4-quinoline methanol (WR30090), and quinine for falciparum malaria in Thailand.Transactions of the Royal Society of Tropical Medicine and Hygiene, , Volume: 69, Issue:3, 1975
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Plasma 11-hydroxycorticoid levels after carbenoxolone sodium.British medical journal, , Aug-29, Volume: 3, Issue:5721, 1970
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New synthetic compounds in the treatment of amoebiasis.Journal of the Indian Medical Association, , Apr-16, Volume: 30, Issue:8, 1958
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Protein translation associated to PERK arm is a new target for regulation of metainflammation: A connection with hepatocyte cholesterol.Journal of cellular biochemistry, , Volume: 120, Issue:3, 2019
Sodium tanshinone IIA sulfonate ameliorates hepatic steatosis by inhibiting lipogenesis and inflammation.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 111, 2019
Sodium tanshinone IIA sulfonate prevents lipopolysaccharide-induced inflammation via suppressing nuclear factor-κB signaling pathway in human umbilical vein endothelial cells.Canadian journal of physiology and pharmacology, , Volume: 96, Issue:1, 2018
Association of polycyclic aromatic hydrocarbons exposure with atherosclerotic cardiovascular disease risk: A role of mean platelet volume or club cell secretory protein.Environmental pollution (Barking, Essex : 1987), , Volume: 233, 2018
Triptolide inhibits donor-specific antibody production and attenuates mixed antibody-mediated renal allograft injury.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, , Volume: 18, Issue:5, 2018
Triptolide up-regulates metabotropic glutamate receptor 5 to inhibit microglia activation in the lipopolysaccharide-induced model of Parkinson's disease.Brain, behavior, and immunity, , Volume: 71, 2018
Improved Reperfusion and Vasculoprotection by the Poly(ADP-Ribose)Polymerase Inhibitor PJ34 After Stroke and Thrombolysis in Mice.Molecular neurobiology, , Volume: 55, Issue:12, 2018
Cryptotanshinone Attenuates Oxidative Stress and Inflammation through the Regulation of Nrf-2 and NF-κB in Mice with Unilateral Ureteral Obstruction.Basic & clinical pharmacology & toxicology, , Volume: 123, Issue:6, 2018
Triptolide inhibits the inflammatory activities of neutrophils to ameliorate chronic arthritis.Molecular immunology, , Volume: 101, 2018
Triptolide mitigates radiation-induced pneumonitis via inhibition of alveolar macrophages and related inflammatory molecules.Oncotarget, , Jul-11, Volume: 8, Issue:28, 2017
Synergic effects of 9,10-phenanthrenequinone and cadmium on pro-inflammatory responses in airway epithelial cells.Environmental toxicology and pharmacology, , Volume: 52, 2017
Sodium tanshinone IIA sulfonate improves inflammation, aortic endothelial cell apoptosis, disseminated intravascular coagulation and multiple organ damage in a rat heat stroke model.Molecular medicine reports, , Volume: 16, Issue:1, 2017
Triptolide-Assisted Phosphorylation of p53 Suppresses Inflammation-Induced NF-κB Survival Pathways in Cancer Cells.Molecular and cellular biology, , 08-01, Volume: 37, Issue:15, 2017
Triptolide exerts protective effects against fibrosis following ileocolonic anastomosis by mechanisms involving the miR-16-1/HSP70 pathway in IL-10-deficient mice.International journal of molecular medicine, , Volume: 40, Issue:2, 2017
Cryptotanshinone protects against IL-1β-induced inflammation in human osteoarthritis chondrocytes and ameliorates the progression of osteoarthritis in mice.International immunopharmacology, , Volume: 50, 2017
Tanshinone IIA Sodium sulfonate regulates antioxidant system, inflammation, and endothelial dysfunction in atherosclerosis by downregulation of CLIC1.European journal of pharmacology, , Nov-15, Volume: 815, 2017
Sodium tanshinone IIA sulfonate attenuates hemorrhagic shock-induced organ damages by nuclear factor-kappa B pathway.The Journal of surgical research, , Volume: 209, 2017
Frataxin Deficiency Promotes Excess Microglial DNA Damage and Inflammation that Is Rescued by PJ34.PloS one, , Volume: 11, Issue:3, 2016
A novel selective prostaglandin E2 synthesis inhibitor relieves pyrexia and arthritis in Guinea pigs inflammatory models.Journal of pharmacological sciences, , Volume: 130, Issue:2, 2016
Triptolide Attenuates Inflammatory Response in Membranous Glomerulo-Nephritis Rat via Downregulation of NF-κB Signaling Pathway.Kidney & blood pressure research, , Volume: 41, Issue:6, 2016
Antidepressant effects of TBE-31 and MCE-1, the novel Nrf2 activators, in an inflammation model of depression.European journal of pharmacology, , Dec-15, Volume: 793, 2016
Protective effects of triptolide on TLR4 mediated autoimmune and inflammatory response induced myocardial fibrosis in diabetic cardiomyopathy.Journal of ethnopharmacology, , Dec-04, Volume: 193, 2016
Triptolide (TPL) improves locomotor function recovery in rats and reduces inflammation after spinal cord injury.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, , Volume: 36, Issue:5, 2015
Tripchlorolide ameliorates experimental autoimmune encephalomyelitis by down-regulating ERK1/2-NF-κB and JAK/STAT signaling pathways.Journal of neurochemistry, , Volume: 133, Issue:1, 2015
Denbinobin upregulates miR-146a expression and attenuates IL-1β-induced upregulation of ICAM-1 and VCAM-1 expressions in osteoarthritis fibroblast-like synoviocytes.Journal of molecular medicine (Berlin, Germany), , Volume: 92, Issue:11, 2014
The poly(adenosine diphosphate-ribose) polymerase inhibitor PJ34 reduces pulmonary ischemia-reperfusion injury in rats.Transplantation, , Sep-27, Volume: 98, Issue:6, 2014
Triptolide preserves cognitive function and reduces neuropathology in a mouse model of Alzheimer's disease.PloS one, , Volume: 9, Issue:9, 2014
PPARγ and RXR ligands disrupt the inflammatory cross-talk in the hypoxic breast cancer stem cells niche.Journal of cellular physiology, , Volume: 229, Issue:11, 2014
Complete Freund's adjuvant-induced acute inflammatory pain could be attenuated by triptolide via inhibiting spinal glia activation in rats.The Journal of surgical research, , May-01, Volume: 188, Issue:1, 2014
TAB1: a target of triptolide in macrophages.Chemistry & biology, , Feb-20, Volume: 21, Issue:2, 2014
Anti-inflammatory phenanthrene derivatives from stems of Dendrobium denneanum.Phytochemistry, , Volume: 95, 2013
Triptolide in the treatment of psoriasis and other immune-mediated inflammatory diseases.British journal of clinical pharmacology, , Volume: 74, Issue:3, 2012
Biological activity and safety of Tripterygium extract prepared by sodium carbonate extraction.Molecules (Basel, Switzerland), , Sep-17, Volume: 17, Issue:9, 2012
Local suppression of pro-inflammatory cytokines and the effects in BMP-2-induced bone regeneration.Biomaterials, , Volume: 33, Issue:1, 2012
MKP-1: a negative feedback effector that represses MAPK-mediated pro-inflammatory signaling pathways and cytokine secretion in human airway smooth muscle cells.Cellular signalling, , Volume: 24, Issue:4, 2012
Nuclear receptors agonists exert opposing effects on the inflammation dependent survival of breast cancer stem cells.Cell death and differentiation, , Volume: 19, Issue:7, 2012
Cryptotanshinone suppressed inflammatory cytokines secretion in RAW264.7 macrophages through inhibition of the NF-κB and MAPK signaling pathways.Inflammation, , Volume: 34, Issue:2, 2011
Potent anti-inflammatory effects of denbinobin mediated by dual inhibition of expression of inducible no synthase and cyclooxygenase 2.Shock (Augusta, Ga.), , Volume: 35, Issue:2, 2011
Triptolide, histone acetyltransferase inhibitor, suppresses growth and chemosensitizes leukemic cells through inhibition of gene expression regulated by TNF-TNFR1-TRADD-TRAF2-NIK-TAK1-IKK pathway.Biochemical pharmacology, , Nov-01, Volume: 82, Issue:9, 2011
Triptolide promotes spinal cord repair by inhibiting astrogliosis and inflammation.Glia, , Volume: 58, Issue:8, 2010
The natural flavonoid apigenin suppresses Th1- and Th2-related chemokine production by human monocyte THP-1 cells through mitogen-activated protein kinase pathways.Journal of medicinal food, , Volume: 13, Issue:2, 2010
9,10-dihydro-2,5-dimethoxyphenanthrene-1,7-diol, from Eulophia ochreata, inhibits inflammatory signalling mediated by Toll-like receptors.British journal of pharmacology, , Volume: 160, Issue:5, 2010
Tanshinone II A attenuates inflammatory responses of rats with myocardial infarction by reducing MCP-1 expression.Phytomedicine : international journal of phytotherapy and phytopharmacology, , Volume: 17, Issue:3-4, 2010
Anti-inflammatory effects of tanshinone IIA on radiation-induced microglia BV-2 cells inflammatory response.Cancer biotherapy & radiopharmaceuticals, , Volume: 24, Issue:6, 2009
Inhibition of poly(ADP-ribose) polymerase suppresses inflammation and promotes recovery after ischemic injury.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, , Volume: 29, Issue:4, 2009
Triptolide inhibits COX-2 expression and PGE2 release by suppressing the activity of NF-kappaB and JNK in LPS-treated microglia.Journal of neurochemistry, , Volume: 107, Issue:3, 2008
Tanshinone IIA suppresses inflammatory bone loss by inhibiting the synthesis of prostaglandin E2 in osteoblasts.European journal of pharmacology, , Dec-28, Volume: 601, Issue:1-3, 2008
PARP1 is required for adhesion molecule expression in atherogenesis.Cardiovascular research, , Apr-01, Volume: 78, Issue:1, 2008
Inflammation in Parkinson's disease: an update.Current opinion in investigational drugs (London, England : 2000), , Volume: 9, Issue:5, 2008
Triptolide modulates T-cell inflammatory responses and ameliorates experimental autoimmune encephalomyelitis.Journal of neuroscience research, , Aug-15, Volume: 86, Issue:11, 2008
Use of a poly(ADP-ribose) polymerase inhibitor to suppress inflammation and neuronal death after cerebral ischemia-reperfusion.Stroke, , Volume: 38, Issue:2 Suppl, 2007
Triptolide, a diterpenoid triepoxide, suppresses inflammation and cartilage destruction in collagen-induced arthritis mice.Biochemical pharmacology, , Jan-01, Volume: 73, Issue:1, 2007
Triptolide suppresses proinflammatory cytokine-induced matrix metalloproteinase and aggrecanase-1 gene expression in chondrocytes.Biochemical and biophysical research communications, , Feb-04, Volume: 327, Issue:1, 2005
Triptolide, a Chinese herbal extract, protects dopaminergic neurons from inflammation-mediated damage through inhibition of microglial activation.Journal of neuroimmunology, , Volume: 148, Issue:1-2, 2004
The function of mitogen-activated protein kinase phosphatase-1 in peptidoglycan-stimulated macrophages.The Journal of biological chemistry, , Dec-24, Volume: 279, Issue:52, 2004
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Attempts to find new antimalarials; derivatives of phenanthrene; amino alcohols of the type -CHOHCH2NR3, derived from 9-bromophenanthrene.The Journal of organic chemistry, , Volume: 11, Issue:4, 1946
Attempts to find new antimalarials; derivatives of phenanthrene; amino alcohols of the type -CHOHCH(CH3)NR2 and amino ketones of the type COCH2CH2NR2 derived from 9-bromophenanthrene.The Journal of organic chemistry, , Volume: 11, Issue:4, 1946
Attempts to find new antimalarials; derivatives of phenanthrene; 1(or 8)-acetyl-9-halophenanthrene.The Journal of organic chemistry, , Volume: 11, Issue:4, 1946
Attempts to find new antimalarials; derivatives of phenanthrene; amino alcohols derived from 9-chlorophenanthrene.The Journal of organic chemistry, , Volume: 11, Issue:4, 1946
Attempts to find new antimalarials; alkanolamines derived from phenanthrene and anthracene.The Journal of organic chemistry, , Volume: 11, Issue:4, 1946
Attempts to find new antimalarials; amino alcohols of type, CHOHCH2NR2 derived from 3-chloro-9-acetylphenanthrene.The Journal of organic chemistry, , Volume: 11, Issue:5, 1946
Attempts to find new antimalarials; amino alcohols of the type, CHOHCH2NR2 derived from 3-chloro-6-acetylphenanthrene.The Journal of organic chemistry, , Volume: 11, Issue:5, 1946
Attempts to find new antimalarials; amino alcohols of the type, CHOHCH2NR2 derived from 3-chloro-10-acetylphenanthrene.The Journal of organic chemistry, , Volume: 11, Issue:5, 1946
Attempts to find new antimalarials; amino alcohols of the type=m=mCHOHCH2NR2 derived from 3-bromo-10-acetyl-phenanthrene.The Journal of organic chemistry, , Volume: 11, Issue:6, 1946
Attempts to find new antimalarials; amino alcohols of the type=m=mCH2CHOHCH2NR2 derived from phenanthrene and tetrahydrophenanthrene.The Journal of organic chemistry, , Volume: 11, Issue:6, 1946
Attempts to find new antimalarials; amino alcohols of the type=m=mCHOHCH2NR2 derived from dichlorophenanthrenes.The Journal of organic chemistry, , Volume: 11, Issue:6, 1946
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Sodium tanshinone IIA sulfonate affects Marek's disease virus replication by inhibiting gB expression.Pharmaceutical biology, , Volume: 54, Issue:4, 2016
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Triptolide inhibits the proliferation and migration of medulloblastoma Daoy cells by upregulation of microRNA-138.Journal of cellular biochemistry, , Volume: 119, Issue:12, 2018
CAT3, a novel agent for medulloblastoma and glioblastoma treatment, inhibits tumor growth by disrupting the Hedgehog signaling pathway.Cancer letters, , 10-28, Volume: 381, Issue:2, 2016
αvβ3 integrin-specific exosomes engineered with cyclopeptide for targeted delivery of triptolide against malignant melanoma.Journal of nanobiotechnology, , Aug-23, Volume: 20, Issue:1, 2022
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Engineering Exosomes Endowed with Targeted Delivery of Triptolide for Malignant Melanoma Therapy.ACS applied materials & interfaces, , Sep-15, Volume: 13, Issue:36, 2021
Triptolide modulates tumour-colonisation and anti-tumour effect of attenuated Salmonella encoding DNase I.Applied microbiology and biotechnology, , Volume: 103, Issue:2, 2019
An in-silico study examining the induction of apoptosis by Cryptotanshinone in metastatic melanoma cell lines.BMC cancer, , Aug-29, Volume: 18, Issue:1, 2018
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Cryptotanshinone induces melanoma cancer cells apoptosis via ROS-mitochondrial apoptotic pathway and impairs cell migration and invasion.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 82, 2016
Triptolide induces S phase arrest via the inhibition of cyclin E and CDC25A and triggers apoptosis via caspase- and mitochondrial-dependent signaling pathways in A375.S2 human melanoma cells.Oncology reports, , Volume: 29, Issue:3, 2013
Triptolide induced DNA damage in A375.S2 human malignant melanoma cells is mediated via reduction of DNA repair genes.Oncology reports, , Volume: 29, Issue:2, 2013
Triptolide downregulates Treg cells and the level of IL-10, TGF-β, and VEGF in melanoma-bearing mice.Planta medica, , Volume: 79, Issue:15, 2013
Triptolide inhibits proliferation and induces apoptosis of human melanoma A375 cells.Asian Pacific journal of cancer prevention : APJCP, , Volume: 13, Issue:4, 2012
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Cryptotanshinone has diverse effects on cell cycle events in melanoma cell lines with different metastatic capacity.Cancer chemotherapy and pharmacology, , Volume: 68, Issue:1, 2011
Inhibition of PARP activity by PJ-34 leads to growth impairment and cell death associated with aberrant mitotic pattern and nucleolar actin accumulation in M14 melanoma cell line.Journal of cellular physiology, , Volume: 222, Issue:2, 2010
Triptolide inhibits the growth and metastasis of solid tumors.Molecular cancer therapeutics, , Volume: 2, Issue:1, 2003
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Suppression of the migration and invasion is mediated by triptolide in B16F10 mouse melanoma cells through the NF-kappaB-dependent pathway.Environmental toxicology, , Volume: 31, Issue:12, 2016
Inhibition of Cancer Angiogenesis Using Triptolide Nanoparticles.Journal of biomedical nanotechnology, , Volume: 11, Issue:5, 2015
Cryptotanshinone has diverse effects on cell cycle events in melanoma cell lines with different metastatic capacity.Cancer chemotherapy and pharmacology, , Volume: 68, Issue:1, 2011
Carnosol inhibits the invasion of B16/F10 mouse melanoma cells by suppressing metalloproteinase-9 through down-regulating nuclear factor-kappa B and c-Jun.Biochemical pharmacology, , Jan-15, Volume: 69, Issue:2, 2005
Triptolide inhibits the growth and metastasis of solid tumors.Molecular cancer therapeutics, , Volume: 2, Issue:1, 2003
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Triptolide Rescues Spatial Memory Deficits and Amyloid-β Aggregation Accompanied by Inhibition of Inflammatory Responses and MAPKs Activity in APP/PS1 Transgenic Mice.Current Alzheimer research, , Volume: 13, Issue:3, 2016
Triptolide preserves cognitive function and reduces neuropathology in a mouse model of Alzheimer's disease.PloS one, , Volume: 9, Issue:9, 2014
Tanshinone I enhances learning and memory, and ameliorates memory impairment in mice via the extracellular signal-regulated kinase signalling pathway.British journal of pharmacology, , Volume: 158, Issue:4, 2009
Cryptotanshinone, a compound from Salvia miltiorrhiza modulates amyloid precursor protein metabolism and attenuates beta-amyloid deposition through upregulating alpha-secretase in vivo and in vitro.Neuroscience letters, , Mar-13, Volume: 452, Issue:2, 2009
Tanshinone congeners improve memory impairments induced by scopolamine on passive avoidance tasks in mice.European journal of pharmacology, , Nov-28, Volume: 574, Issue:2-3, 2007
Triptolide suppresses oral cancer cell PD-L1 expression in the interferon-γ-modulated microenvironment in vitro, in vivo, and in clinical patients.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 133, 2021
Anti-oral cancer effects of triptolide by downregulation of DcR3 in vitro, in vivo, and in preclinical patient-derived tumor xenograft model.Head & neck, , Volume: 41, Issue:5, 2019
STAT3- and GSK3β-mediated Mcl-1 regulation modulates TPF resistance in oral squamous cell carcinoma.Carcinogenesis, , 03-12, Volume: 40, Issue:1, 2019
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KO-202125, a sauristolactam derivate, induces apoptosis to prevent KB human oral squamous carcinoma cells through inhibition of cyclooxygenase-2 expression.European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP), , Volume: 19, Issue:1, 2010
Triptolide exerts anti-tumor effect on oral cancer and KB cells in vitro and in vivo.Oral oncology, , Volume: 45, Issue:7, 2009
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Effects of miR-32 targeting PTEN on proliferation and apoptosis of myeloma cells.European review for medical and pharmacological sciences, , Volume: 24, Issue:7, 2020
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Triptolide blocks the STAT3 signaling pathway through induction of protein tyrosine phosphatase SHP-1 in multiple myeloma cells.International journal of molecular medicine, , Volume: 40, Issue:5, 2017
Triptolide Induces Cell Apoptosis by Targeting H3K4me3 and Downstream Effector Proteins in KM3 Multiple Myeloma Cells.Current pharmaceutical biotechnology, , Volume: 17, Issue:2, 2015
PJ34, a poly(ADP-ribose) polymerase (PARP) inhibitor, reverses melphalan-resistance and inhibits repair of DNA double-strand breaks by targeting the FA/BRCA pathway in multidrug resistant multiple myeloma cell line RPMI8226/R.International journal of oncology, , Volume: 46, Issue:1, 2015
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Triptolide induces apoptotic cell death of multiple myeloma cells via transcriptional repression of Mcl-1.International journal of oncology, , Volume: 44, Issue:4, 2014
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Triptolide enhances the sensitivity of multiple myeloma cells to dexamethasone via microRNAs.Leukemia & lymphoma, , Volume: 53, Issue:6, 2012
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Triptolide induces cell-cycle arrest and apoptosis of human multiple myeloma cells in vitro via altering expression of histone demethylase LSD1 and JMJD2B.Acta pharmacologica Sinica, , Volume: 33, Issue:1, 2012
Triptolide-induced apoptosis by inactivating nuclear factor-kappa B apoptotic pathway in multiple myeloma in vitro.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, , Volume: 31, Issue:4, 2011
Role of triptolide in cell proliferation, cell cycle arrest, apoptosis and histone methylation in multiple myeloma U266 cells.European journal of pharmacology, , Nov-10, Volume: 646, Issue:1-3, 2010
Triptolide alters histone H3K9 and H3K27 methylation state and induces G0/G1 arrest and caspase-dependent apoptosis in multiple myeloma in vitro.Toxicology, , Jan-12, Volume: 267, Issue:1-3, 2010
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Interleukin-6-independent expression of glucocorticoid receptor is upregulated by triptolide in multiple myeloma.Leukemia & lymphoma, , Volume: 50, Issue:5, 2009
Triptolide overcomes dexamethasone resistance and enhanced PS-341-induced apoptosis via PI3k/Akt/NF-kappaB pathways in human multiple myeloma cells.International journal of molecular medicine, , Volume: 22, Issue:4, 2008
Triptolide inhibits transcription factor NF-kappaB and induces apoptosis of multiple myeloma cells.Leukemia research, , Volume: 29, Issue:1, 2005
Triptolide induces atrophy of myotubes by triggering IRS-1 degradation and activating the FoxO3 pathway.Toxicology in vitro : an international journal published in association with BIBRA, , Volume: 65, 2020
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Arsenic trioxide and triptolide synergistically induce apoptosis in the SKM‑1 human myelodysplastic syndrome cell line.Molecular medicine reports, , Volume: 14, Issue:5, 2016
Inhibitors of poly ADP-ribose polymerase (PARP) induce apoptosis of myeloid leukemic cells: potential for therapy of myeloid leukemia and myelodysplastic syndromes.Haematologica, , Volume: 94, Issue:5, 2009
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Prevention of endotoxin-induced cardiomyopathy using sodium tanshinone IIA sulfonate: Involvement of augmented autophagy and NLRP3 inflammasome suppression.European journal of pharmacology, , Oct-15, Volume: 909, 2021
Protective effects of triptolide on TLR4 mediated autoimmune and inflammatory response induced myocardial fibrosis in diabetic cardiomyopathy.Journal of ethnopharmacology, , Dec-04, Volume: 193, 2016
Cryptotanshinone protects against adriamycin-induced mitochondrial dysfunction in cardiomyocytes.Pharmaceutical biology, , Volume: 54, Issue:2, 2016
Sodium Tanshinone IIA Sulfonate Improves Adverse Ventricular Remodeling Post-MI by Reducing Myocardial Necrosis, Modulating Inflammation, and Promoting Angiogenesis.Current pharmaceutical design, , Volume: 28, Issue:9, 2022
Sodium Tanshinone IIA sulfonate for acute myocardial infarction: a systematic review and Meta-analysis.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, , Volume: 41, Issue:1, 2021
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Cryptotanshinone attenuates cardiac fibrosis via downregulation of COX-2, NOX-2, and NOX-4.Journal of cardiovascular pharmacology, , Volume: 64, Issue:1, 2014
The cardioprotective effect of sodium tanshinone IIA sulfonate and the optimizing of therapeutic time window in myocardial ischemia/reperfusion injury in rats.Atherosclerosis, , Volume: 235, Issue:2, 2014
Sodium tanshinone IIA sulfonate protects rat myocardium against ischemia-reperfusion injury via activation of PI3K/Akt/FOXO3A/Bim pathway.Acta pharmacologica Sinica, , Volume: 34, Issue:11, 2013
Nanovesicles system for rapid-onset sublingual delivery containing sodium tanshinone IIA sulfonate: in vitro and in vivo evaluation.Journal of pharmaceutical sciences, , Volume: 102, Issue:7, 2013
Regulation of antioxidant system, lipids and fatty acid β-oxidation contributes to the cardioprotective effect of sodium tanshinone IIA sulphonate in isoproterenol-induced myocardial infarction in rats.Atherosclerosis, , Volume: 230, Issue:1, 2013
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Tanshinone IIA pretreatment protects myocardium against ischaemia/reperfusion injury through the phosphatidylinositol 3-kinase/Akt-dependent pathway in diabetic rats.Diabetes, obesity & metabolism, , Volume: 12, Issue:4, 2010
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Effect of triptolide and chemotherapy on carcinoembryonic and carbohydrate antigens levels and first-line treatment of recurrent nasopharyngeal carcinoma.Cellular and molecular biology (Noisy-le-Grand, France), , Aug-31, Volume: 67, Issue:2, 2021
Downregulation of miR-144 by triptolide enhanced p85α-PTEN complex formation causing S phase arrest of human nasopharyngeal carcinoma cells.European journal of pharmacology, , Jul-15, Volume: 855, 2019
Triptolide inhibits Epstein-Barr nuclear antigen 1 expression by increasing sensitivity of mitochondria apoptosis of nasopharyngeal carcinoma cells.Journal of experimental & clinical cancer research : CR, , Aug-15, Volume: 37, Issue:1, 2018
Triptolide inhibits cell growth and GRP78 protein expression but induces cell apoptosis in original and radioresistant NPC cells.Oncotarget, , Aug-02, Volume: 7, Issue:31, 2016
Triptolide Combined with Radiotherapy for the Treatment of Nasopharyngeal Carcinoma via NF-κB-Related Mechanism.International journal of molecular sciences, , Dec-19, Volume: 17, Issue:12, 2016
Triptolide Induces Apoptosis and Synergizes with Cisplatin in Cisplatin-Resistant HNE1/DDP Nasopharyngeal Cancer Cells.Folia biologica, , Volume: 61, Issue:5, 2015
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LYW-6, a novel cryptotanshinone derived STAT3 targeting inhibitor, suppresses colorectal cancer growth and metastasis.Pharmacological research, , Volume: 153, 2020
Dihydrotanshinone I inhibits ovarian cancer cell proliferation and migration by transcriptional repression of PIK3CA gene.Journal of cellular and molecular medicine, , Volume: 24, Issue:19, 2020
Dehydroeffusol inhibits hypoxia-induced epithelial-mesenchymal transition in non-small cell lung cancer cells through the inactivation of Wnt/β-catenin pathway.Bioscience reports, , 05-29, Volume: 40, Issue:5, 2020
EMT-related protein expression in polyploid giant cancer cells and their daughter cells with different passages after triptolide treatment.Medical oncology (Northwood, London, England), , Aug-12, Volume: 36, Issue:9, 2019
Cryptotanshinone inhibits the growth and invasion of colon cancer by suppressing inflammation and tumor angiogenesis through modulating MMP/TIMP system, PI3K/Akt/mTOR signaling and HIF-1α nuclear translocation.International immunopharmacology, , Volume: 65, 2018
Dehydroeffusol inhibits viability and epithelial-mesenchymal transition through the Hedgehog and Akt/mTOR signaling pathways in neuroblastoma cells.European journal of pharmacology, , Jun-15, Volume: 829, 2018
A new synthetic derivative of cryptotanshinone KYZ3 as STAT3 inhibitor for triple-negative breast cancer therapy.Cell death & disease, , 10-27, Volume: 9, Issue:11, 2018
EGFR inhibition by (-)-epigallocatechin-3-gallate and IIF treatments reduces breast cancer cell invasion.Bioscience reports, , Jun-30, Volume: 37, Issue:3, 2017
Cryptotanshinone sensitizes antitumor effect of paclitaxel on tongue squamous cell carcinoma growth by inhibiting the JAK/STAT3 signaling pathway.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 95, 2017
Triptolide inhibits the growth of osteosarcoma by regulating microRNA-181a via targeting PTEN gene in vivo and vitro.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, , Volume: 39, Issue:4, 2017
AMD3100 combined with triptolide inhibit proliferation, invasion and metastasis and induce apoptosis of human U2OS osteosarcoma cells.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 86, 2017
Anti-tumor and chemosensitization effects of Cryptotanshinone extracted from Salvia miltiorrhiza Bge. on ovarian cancer cells in vitro.Journal of ethnopharmacology, , Jun-09, Volume: 205, 2017
Enhancement of triptolide-loaded micelles on tumorigenicity inhibition of human ovarian cancer.Journal of biomaterials science. Polymer edition, , Volume: 27, Issue:7, 2016
Suppression of the migration and invasion is mediated by triptolide in B16F10 mouse melanoma cells through the NF-kappaB-dependent pathway.Environmental toxicology, , Volume: 31, Issue:12, 2016
The triptolide derivative MRx102 inhibits Wnt pathway activation and has potent anti-tumor effects in lung cancer.BMC cancer, , 07-11, Volume: 16, 2016
Triptolide inhibits the migration and invasion of human prostate cancer cells via Caveolin-1/CD147/MMPs pathway.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 84, 2016
Cryptotanshinone induces melanoma cancer cells apoptosis via ROS-mitochondrial apoptotic pathway and impairs cell migration and invasion.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 82, 2016
Triptolide Inhibits Lung Cancer Cell Migration, Invasion, and Metastasis.The Annals of thoracic surgery, , Volume: 100, Issue:5, 2015
The novel anti-neuroblastoma agent PF403, inhibits proliferation and invasion in vitro and in brain xenografts.International journal of oncology, , Volume: 47, Issue:1, 2015
Design, synthesis and biological evaluation of 1-phenanthryl-tetrahydroisoquinoline derivatives as novel p21-activated kinase 4 (PAK4) inhibitors.Organic & biomolecular chemistry, , Mar-28, Volume: 13, Issue:12, 2015
Triptolide inhibits ovarian cancer cell invasion by repression of matrix metalloproteinase 7 and 19 and upregulation of E-cadherin.Experimental & molecular medicine, , Nov-30, Volume: 44, Issue:11, 2012
Triptolide inhibits proliferation and invasion of malignant glioma cells.Journal of neuro-oncology, , Volume: 109, Issue:1, 2012
Denbinobin, a phenanthrene from dendrobium nobile, inhibits invasion and induces apoptosis in SNU-484 human gastric cancer cells.Oncology reports, , Volume: 27, Issue:3, 2012
p38γ mitogen-activated protein kinase contributes to oncogenic properties maintenance and resistance to poly (ADP-ribose)-polymerase-1 inhibition in breast cancer.Neoplasia (New York, N.Y.), , Volume: 13, Issue:5, 2011
Triptolide, histone acetyltransferase inhibitor, suppresses growth and chemosensitizes leukemic cells through inhibition of gene expression regulated by TNF-TNFR1-TRADD-TRAF2-NIK-TAK1-IKK pathway.Biochemical pharmacology, , Nov-01, Volume: 82, Issue:9, 2011
Inhibitive effect of triptolide on invasiveness of human fibrosarcoma cells by downregulating matrix metalloproteinase-9 expression.Asian Pacific journal of tropical medicine, , Volume: 4, Issue:6, 2011
Poly(ADP-ribose)-dependent regulation of Snail1 protein stability.Oncogene, , Oct-20, Volume: 30, Issue:42, 2011
A small-molecule triptolide suppresses angiogenesis and invasion of human anaplastic thyroid carcinoma cells via down-regulation of the nuclear factor-kappa B pathway.Molecular pharmacology, , Volume: 75, Issue:4, 2009
Inhibitory effects of tanshinone II-A on invasion and metastasis of human colon carcinoma cells.Acta pharmacologica Sinica, , Volume: 30, Issue:11, 2009
Tanshinone I suppresses growth and invasion of human breast cancer cells, MDA-MB-231, through regulation of adhesion molecules.Carcinogenesis, , Volume: 29, Issue:10, 2008
Induction of apoptosis and inhibition of cell adhesive and invasive effects by tanshinone IIA in acute promyelocytic leukemia cells in vitro.Journal of biomedical science, , Volume: 13, Issue:6, 2006
Triptolide inhibits tumor promoter-induced uPAR expression via blocking NF-kappaB signaling in human gastric AGS cells.Anticancer research, , Volume: 27, Issue:5A
Tanshinone II-A inhibits invasion and metastasis of human hepatocellular carcinoma cells in vitro and in vivo.Tumori, , Volume: 95, Issue:6
LYW-6, a novel cryptotanshinone derived STAT3 targeting inhibitor, suppresses colorectal cancer growth and metastasis.Pharmacological research, , Volume: 153, 2020
Dihydrotanshinone I inhibits ovarian cancer cell proliferation and migration by transcriptional repression of PIK3CA gene.Journal of cellular and molecular medicine, , Volume: 24, Issue:19, 2020
Triptolide Inhibits Breast Cancer Cell Metastasis Through Inducing the Expression of miR-146a, a Negative Regulator of Rho GTPase.Oncology research, , Sep-23, Volume: 27, Issue:9, 2019
Triptolide prevents proliferation and migration of Esophageal Squamous Cell Cancer via MAPK/ERK signaling pathway.European journal of pharmacology, , May-15, Volume: 851, 2019
AMD3100 combined with triptolide inhibit proliferation, invasion and metastasis and induce apoptosis of human U2OS osteosarcoma cells.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 86, 2017
GD3 synthase regulates epithelial-mesenchymal transition and metastasis in breast cancer.Oncogene, , Jun-04, Volume: 34, Issue:23, 2015
Triptolide Inhibits Lung Cancer Cell Migration, Invasion, and Metastasis.The Annals of thoracic surgery, , Volume: 100, Issue:5, 2015
15,16-Dihydrotanshinone I-induced apoptosis in human colorectal cancer cells: involvement of ATF3.Anticancer research, , Volume: 33, Issue:8, 2013
NF-κB inhibition significantly upregulates the norepinephrine transporter system, causes apoptosis in pheochromocytoma cell lines and prevents metastasis in an animal model.International journal of cancer, , Nov-15, Volume: 131, Issue:10, 2012
Denbinobin suppresses breast cancer metastasis through the inhibition of Src-mediated signaling pathways.The Journal of nutritional biochemistry, , Volume: 22, Issue:8, 2011
p38γ mitogen-activated protein kinase contributes to oncogenic properties maintenance and resistance to poly (ADP-ribose)-polymerase-1 inhibition in breast cancer.Neoplasia (New York, N.Y.), , Volume: 13, Issue:5, 2011
Triptolide, histone acetyltransferase inhibitor, suppresses growth and chemosensitizes leukemic cells through inhibition of gene expression regulated by TNF-TNFR1-TRADD-TRAF2-NIK-TAK1-IKK pathway.Biochemical pharmacology, , Nov-01, Volume: 82, Issue:9, 2011
Inhibitory effects of tanshinone II-A on invasion and metastasis of human colon carcinoma cells.Acta pharmacologica Sinica, , Volume: 30, Issue:11, 2009
Tanshinone IIA: a potent, natural anti-carcinogenic agent for the management of systemic malignancies.Chinese journal of integrative medicine, , Volume: 15, Issue:2, 2009
Anticancer effects of tanshinone I in human non-small cell lung cancer.Molecular cancer therapeutics, , Volume: 7, Issue:11, 2008
Triptolide inhibits the growth and metastasis of solid tumors.Molecular cancer therapeutics, , Volume: 2, Issue:1, 2003
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Effect of triptolide and chemotherapy on carcinoembryonic and carbohydrate antigens levels and first-line treatment of recurrent nasopharyngeal carcinoma.Cellular and molecular biology (Noisy-le-Grand, France), , Aug-31, Volume: 67, Issue:2, 2021
MYC Inhibition Depletes Cancer Stem-like Cells in Triple-Negative Breast Cancer.Cancer research, , 12-01, Volume: 77, Issue:23, 2017
A comprehensive review on celastrol, triptolide and triptonide: Insights on their pharmacological activity, toxicity, combination therapy, new dosage form and novel drug delivery routes.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 162, 2023
The Syntheses and Medicinal Attributes of Phenanthrenes as Anticancer Agents: A Quinquennial Update.Current medicinal chemistry, , Volume: 29, Issue:20, 2022
Naringenin and cryptotanshinone shift the immune response towards Th1 and modulate T regulatory cells via JAK2/STAT3 pathway in breast cancer.BMC complementary medicine and therapies, , May-23, Volume: 22, Issue:1, 2022
Phytochemicals in Cancer Immune Checkpoint Inhibitor Therapy.Biomolecules, , 07-27, Volume: 11, Issue:8, 2021
Triptolide: reflections on two decades of research and prospects for the future.Natural product reports, , 04-28, Volume: 38, Issue:4, 2021
Comprehensive live-cell imaging analysis of cryptotanshinone and synergistic drug-screening effects in various human and canine cancer cell lines.PloS one, , Volume: 16, Issue:2, 2021
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Cigarette smoking enhances the metabolic activation of the polycyclic aromatic hydrocarbon phenanthrene in humans.Carcinogenesis, , 04-30, Volume: 42, Issue:4, 2021
The Study of Cellular Mechanism of Triptolide in the Treatment of Cancer, Bone Loss and Cardiovascular Disease and Triptolide's Toxicity.Current stem cell research & therapy, , Volume: 15, Issue:1, 2020
Synthesis of naphthalimide-phenanthro[9,10-d]imidazole derivatives: In vitro evaluation, binding interaction with DNA and topoisomerase inhibition.Bioorganic chemistry, , Volume: 96, 2020
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Triptolide, A Potential Autophagy Modulator.Chinese journal of integrative medicine, , Volume: 25, Issue:3, 2019
Status, sources, and risk assessment of polycyclic aromatic hydrocarbons in urban soils of Xi'an, China.Environmental science and pollution research international, , Volume: 25, Issue:19, 2018
Shotgun Proteomics and Quantitative Pathway Analysis of the Mechanisms of Action of Dehydroeffusol, a Bioactive Phytochemical with Anticancer Activity from Juncus effusus.Journal of proteome research, , 07-06, Volume: 17, Issue:7, 2018
An oxanthroquinone derivative that disrupts RAS plasma membrane localization inhibits cancer cell growth.The Journal of biological chemistry, , 08-31, Volume: 293, Issue:35, 2018
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Innovative DNA-Targeted Metallo-prodrug Strategy Combining Histone Deacetylase Inhibition with Oxidative Stress.Molecular pharmaceutics, , 11-05, Volume: 15, Issue:11, 2018
Triptolide inhibits tumor growth by induction of cellular senescence.Oncology reports, , Volume: 37, Issue:1, 2017
Codelivery of doxorubicin and triptolide with reduction-sensitive lipid-polymer hybrid nanoparticles for in vitro and in vivo synergistic cancer treatment.International journal of nanomedicine, , Volume: 12, 2017
Cryptotanshinone activates AMPK-TSC2 axis leading to inhibition of mTORC1 signaling in cancer cells.BMC cancer, , 01-07, Volume: 17, Issue:1, 2017
Exclusive destruction of mitotic spindles in human cancer cells.Oncotarget, , Mar-28, Volume: 8, Issue:13, 2017
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KIFC1: a promising chemotherapy target for cancer treatment?Oncotarget, , Jul-26, Volume: 7, Issue:30, 2016
Cryptotanshinone, a novel tumor angiogenesis inhibitor, destabilizes tumor necrosis factor-α mRNA via decreasing nuclear-cytoplasmic translocation of RNA-binding protein HuR.Molecular carcinogenesis, , Volume: 55, Issue:10, 2016
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eIF4E binding protein 1 expression is associated with clinical survival outcomes in colorectal cancer.Oncotarget, , Sep-15, Volume: 6, Issue:27, 2015
Targeting a ribonucleoprotein complex containing the caprin-1 protein and the c-Myc mRNA suppresses tumor growth in mice: an identification of a novel oncotarget.Oncotarget, , Feb-10, Volume: 6, Issue:4, 2015
Synergistic anticancer effects of triptolide and celastrol, two main compounds from thunder god vine.Oncotarget, , Oct-20, Volume: 6, Issue:32, 2015
Inhibition of Cancer Angiogenesis Using Triptolide Nanoparticles.Journal of biomedical nanotechnology, , Volume: 11, Issue:5, 2015
MCL1 and BCL-xL levels in solid tumors are predictive of dinaciclib-induced apoptosis.PloS one, , Volume: 9, Issue:10, 2014
Triptolide, a diterpene, inhibits osteoclastogenesis, induced by RANKL signaling and human cancer cells.Biochimie, , Volume: 105, 2014
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Triptolide-mediated inhibition of interferon signaling enhances vesicular stomatitis virus-based oncolysis.Molecular therapy : the journal of the American Society of Gene Therapy, , Volume: 21, Issue:11, 2013
Phenanthrenes from Juncus effusus.Planta medica, , Volume: 79, Issue:15, 2013
Herbal compound triptolide synergistically enhanced antitumor activity of vasostatin120-180.Anti-cancer drugs, , Volume: 24, Issue:9, 2013
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Antagonist effect of triptolide on AKT activation by truncated retinoid X receptor-alpha.PloS one, , Volume: 7, Issue:4, 2012
A small molecule inhibitor of p53-inducible protein phosphatase PPM1D.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 22, Issue:1, 2012
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Natural product triptolide mediates cancer cell death by triggering CDK7-dependent degradation of RNA polymerase II.Cancer research, , Oct-15, Volume: 72, Issue:20, 2012
Cytotoxicity and DNA binding property of phenanthrene imidazole with polyglycol side chains.Bioorganic & medicinal chemistry letters, , Oct-15, Volume: 22, Issue:20, 2012
[Identification of two small molecule inhibitors of hypoxia-inducible factor 1 with different cell-based screening model].Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, , Volume: 37, Issue:14, 2012
Cryptotanshinone activates p38/JNK and inhibits Erk1/2 leading to caspase-independent cell death in tumor cells.Cancer prevention research (Philadelphia, Pa.), , Volume: 5, Issue:5, 2012
Platinum(II) phenanthroimidazoles for targeting telomeric G-quadruplexes.ChemMedChem, , Jan-02, Volume: 7, Issue:1, 2012
A phenanthrene derived PARP inhibitor is an extra-centrosomes de-clustering agent exclusively eradicating human cancer cells.BMC cancer, , Sep-26, Volume: 11, 2011
The main anticancer bullets of the Chinese medicinal herb, thunder god vine.Molecules (Basel, Switzerland), , Jun-23, Volume: 16, Issue:6, 2011
Increased accumulation of hypoxia-inducible factor-1α with reduced transcriptional activity mediates the antitumor effect of triptolide.Molecular cancer, , Oct-11, Volume: 9, 2010
Cryptotanshinone inhibits cancer cell proliferation by suppressing Mammalian target of rapamycin-mediated cyclin D1 expression and Rb phosphorylation.Cancer prevention research (Philadelphia, Pa.), , Volume: 3, Issue:8, 2010
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RNA polymerase - an important molecular target of triptolide in cancer cells.Cancer letters, , Jun-28, Volume: 292, Issue:2, 2010
Triptolide and management of systemic malignancies besides pancreatic carcinomas.World journal of gastroenterology, , Feb-28, Volume: 15, Issue:8, 2009
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An indomethacin analogue, N-(4-chlorobenzoyl)-melatonin, is a selective inhibitor of aldo-keto reductase 1C3 (type 2 3alpha-HSD, type 5 17beta-HSD, and prostaglandin F synthase), a potential target for the treatment of hormone dependent and hormone indepeBiochemical pharmacology, , Jan-15, Volume: 75, Issue:2, 2008
Sodium Tanshinone IIA Sulfonate Improves Adverse Ventricular Remodeling Post-MI by Reducing Myocardial Necrosis, Modulating Inflammation, and Promoting Angiogenesis.Current pharmaceutical design, , Volume: 28, Issue:9, 2022
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Dihydrotanshinone I inhibits ovarian tumor growth by activating oxidative stress through Keap1-mediated Nrf2 ubiquitination degradation.Free radical biology & medicine, , 02-20, Volume: 180, 2022
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Functional Exosome-Mediated Delivery of Triptolide Endowed with Targeting Properties as Chemotherapy Carriers for Ovarian Carcinoma.Journal of biomedical nanotechnology, , Mar-01, Volume: 17, Issue:3, 2021
Triptolide inhibits JAK2/STAT3 signaling and induces lethal autophagy through ROS generation in cisplatin‑resistant SKOV3/DDP ovarian cancer cells.Oncology reports, , Volume: 45, Issue:5, 2021
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Cryptotanshinone suppresses cell proliferation and glucose metabolism via STAT3/SIRT3 signaling pathway in ovarian cancer cells.Cancer medicine, , Volume: 7, Issue:9, 2018
Co-Delivery of Triptolide and Curcumin for Ovarian Cancer Targeting Therapy via mPEG-DPPE/CaP Nanoparticle.Journal of biomedical nanotechnology, , Oct-01, Volume: 14, Issue:10, 2018
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Inhibition effect of triptolide on human epithelial ovarian cancer via adjusting cellular immunity and angiogenesis.Oncology reports, , Volume: 39, Issue:3, 2018
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Selective tumor cell killing by triptolide in p53 wild-type and p53 mutant ovarian carcinomas.Medical oncology (Northwood, London, England), , Volume: 31, Issue:7, 2014
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Triptolide inhibits ovarian cancer cell invasion by repression of matrix metalloproteinase 7 and 19 and upregulation of E-cadherin.Experimental & molecular medicine, , Nov-30, Volume: 44, Issue:11, 2012
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A novel selective prostaglandin E2 synthesis inhibitor relieves pyrexia and arthritis in Guinea pigs inflammatory models.Journal of pharmacological sciences, , Volume: 130, Issue:2, 2016
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Macropinocytic dextran facilitates KRAS-targeted delivery while reducing drug-induced tumor immunity depletion in pancreatic cancer.Theranostics, , Volume: 12, Issue:3, 2022
Minnelide synergizes with conventional chemotherapy by targeting both cancer and associated stroma components in pancreatic cancer.Cancer letters, , 07-01, Volume: 537, 2022
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Polypyridyl-Based Copper Phenanthrene Complexes: Combining Stability with Enhanced DNA Recognition.Chemistry (Weinheim an der Bergstrasse, Germany), , Jan-13, Volume: 27, Issue:3, 2021
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Cryptotanshinone, a novel PDK 4 inhibitor, suppresses bladder cancer cell invasiveness via the mTOR/β‑catenin/N‑cadherin axis.International journal of oncology, , Volume: 59, Issue:1, 2021
Sequential delivery of nanoformulated α-mangostin and triptolide overcomes permeation obstacles and improves therapeutic effects in pancreatic cancer.Biomaterials, , Volume: 241, 2020
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Targeting the Oncogene KRAS Mutant Pancreatic Cancer by Synergistic Blocking of Lysosomal Acidification and Rapid Drug Release.ACS nano, , 04-23, Volume: 13, Issue:4, 2019
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Triptolide enhances TRAIL sensitivity of pancreatic cancer cells by activating autophagy via downregulation of PUM1.Phytomedicine : international journal of phytotherapy and phytopharmacology, , Volume: 62, 2019
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Effect of halofantrine on QT interval in children.Pathogens and global health, , Volume: 106, Issue:2, 2012
Identification and functional validation of the novel antimalarial resistance locus PF10_0355 in Plasmodium falciparum.PLoS genetics, , Volume: 7, Issue:4, 2011
In vitro susceptibility of Plasmodium falciparum to monodesethylamodiaquine, quinine, mefloquine and halofantrine in Abidjan (Côte d'Ivoire).African health sciences, , Volume: 10, Issue:2, 2010
Cytotoxic and antiplasmodial compounds from the roots of Strophioblachia fimbricalyx.Journal of natural products, , Volume: 72, Issue:10, 2009
The in-vitro susceptibilities of Ghanaian Plasmodium falciparum to antimalarial drugs.Annals of tropical medicine and parasitology, , Volume: 101, Issue:5, 2007
Decreasing pfmdr1 copy number in plasmodium falciparum malaria heightens susceptibility to mefloquine, lumefantrine, halofantrine, quinine, and artemisinin.The Journal of infectious diseases, , Aug-15, Volume: 194, Issue:4, 2006
Efficacy and safety of halofantrine in Pakistani children and adults with malaria caused by P. falciparum and P. vivax.The Southeast Asian journal of tropical medicine and public health, , Volume: 37, Issue:4, 2006
[Mefloquine versus halofantrine in children suffering from acute uncomplicated falciparum malaria].Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, , Volume: 12 Suppl 1, 2005
Halofantrine efficacy in non-immune children with imported acute Plasmodium falciparum malaria Infection.European journal of pediatrics, , Volume: 163, Issue:1, 2004
Emerging drug--resistance and guidelines for treatment of malaria.Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, , Volume: 14, Issue:5, 2004
Defective DNA repair as a potential mechanism for the rapid development of drug resistance in Plasmodium falciparum.Biochemistry, , May-04, Volume: 43, Issue:17, 2004
Genetic and biochemical aspects of drug resistance in malaria parasites.Current drug targets. Infectious disorders, , Volume: 4, Issue:1, 2004
In vitro activity of chloroquine, quinine, mefloquine and halofantrine against Gabonese isolates of Plasmodium falciparum.Tropical medicine & international health : TM & IH, , Volume: 8, Issue:1, 2003
Short report: in vivo sensitivity of Plasmodium falciparum to halofantrine in southern central Vietnam.The American journal of tropical medicine and hygiene, , Volume: 69, Issue:5, 2003
The clinical spectrum of severe imported falciparum malaria in the intensive care unit: report of 188 cases in adults.American journal of respiratory and critical care medicine, , Mar-01, Volume: 167, Issue:5, 2003
[Treatment of uncomplicated Plasmodium falciparum malaria in children: comparison of halofantrine with mefloquine].Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, , Volume: 10 Suppl 5, 2003
In-vitro sensitivity of Plasmodium falciparum to chloroquine, halofantrine, mefloquine and quinine in Madagascar.East African medical journal, , Volume: 79, Issue:5, 2002
Atovaquone + proguanil: new preparation. Second-line antimalarial combination.Prescrire international, , Volume: 11, Issue:61, 2002
The effects of antimalarial drugs on ventricular repolarization.The American journal of tropical medicine and hygiene, , Volume: 67, Issue:1, 2002
[A collective malarial infestation during a humanitarian mission in west Africa].Bulletin de la Societe de pathologie exotique (1990), , Volume: 95, Issue:2, 2002
Apparent drug failure following artesunate treatment of Plasmodium falciparum malaria in Freetown, Sierra Leone: four case reports.Annals of tropical medicine and parasitology, , Volume: 95, Issue:5, 2001
Clinical trial of halofantrine with modified doses for treatment of malaria in the hospital for tropical diseases.The Southeast Asian journal of tropical medicine and public health, , Volume: 32, Issue:2, 2001
[Epidemiological and therapeutic aspects of plasmodial infection from Plasmodium vivax].Medecine tropicale : revue du Corps de sante colonial, , Volume: 60, Issue:4, 2000
Cytoadherence characteristics of Plasmodium falciparum isolates in Thailand using an in vitro human lung endothelial cells model.The American journal of tropical medicine and hygiene, , Volume: 62, Issue:1, 2000
Malaria chemoprophylaxis with tafenoquine: a randomised study.Lancet (London, England), , Jun-10, Volume: 355, Issue:9220, 2000
Phenotypic and genotypic characteristics of recently adapted isolates of Plasmodium falciparum from Thailand.The American journal of tropical medicine and hygiene, , Volume: 60, Issue:3, 1999
[Health assessments of a military company stationed on the Maroni River in French Guiana].Medecine tropicale : revue du Corps de sante colonial, , Volume: 59, Issue:1, 1999
[Imported pediatric malaria in Marseille].Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, , Volume: 6, Issue:9, 1999
[Long QTc interval complicating halofantrine therapy in 2 children with Plasmodium falciparum malaria].Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, , Volume: 6, Issue:9, 1999
Molecular epidemiology of malaria in Yaounde, Cameroon V. analysis of the omega repetitive region of the plasmodium falciparum CG2 gene and chloroquine resistance.The American journal of tropical medicine and hygiene, , Volume: 61, Issue:5, 1999
Inoculum effect leads to overestimation of in vitro resistance for artemisinin derivatives and standard antimalarials: a Gambian field study.Parasitology, , Volume: 119 ( Pt 5), 1999
Combination atovaquone and proguanil hydrochloride vs. halofantrine for treatment of acute Plasmodium falciparum malaria in children.The Pediatric infectious disease journal, , Volume: 18, Issue:5, 1999
Risk factors for gametocyte carriage in uncomplicated falciparum malaria.The American journal of tropical medicine and hygiene, , Volume: 60, Issue:6, 1999
The comparative efficacy and tolerability of CGP 56697 (artemether + lumefantrine) versus halofantrine in the treatment of uncomplicated falciparum malaria in travellers returning from the Tropics to The Netherlands and France.International journal of antimicrobial agents, , Volume: 12, Issue:2, 1999
In vitro susceptibility of African isolates of Plasmodium falciparum from Gabon to pyronaridine.The American journal of tropical medicine and hygiene, , Volume: 60, Issue:1, 1999
In vitro sensitivity of Plasmodium falciparum to halofantrine compared with chloroquine, quinine and mefloquine in the region of Bobo-Dioulasso, Burkina Faso (West Africa).Tropical medicine & international health : TM & IH, , Volume: 3, Issue:5, 1998
Follow-up of the susceptibility of Plasmodium falciparum to antimalarials in Gabon.The American journal of tropical medicine and hygiene, , Volume: 58, Issue:5, 1998
In vitro activity of artemether against African isolates (Senegal) of Plasmodium falciparum in comparison with standard antimalarial drugs.The American journal of tropical medicine and hygiene, , Volume: 58, Issue:3, 1998
Halofantrine in the treatment of falciparum malaria.JPMA. The Journal of the Pakistan Medical Association, , Volume: 48, Issue:5, 1998
Halofantrine in the treatment of uncomplicated falciparum malaria with a three-dose regimen in Papua New Guinea: a preliminary report.Papua and New Guinea medical journal, , Volume: 41, Issue:1, 1998
In vitro susceptibility of Plasmodium falciparum isolates to halofantrine in the Central Province of Papua New Guinea.Papua and New Guinea medical journal, , Volume: 41, Issue:1, 1998
[Treatment of malaria: let us be sensible!].Presse medicale (Paris, France : 1983), , Jan-24, Volume: 27, Issue:3, 1998
In vitro susceptibility of African Plasmodium falciparum isolates to dihydroartemisinin and the risk factors for resistance to qinghaosu.Medecine tropicale : revue du Corps de sante colonial, , Volume: 58, Issue:3 Suppl, 1998
[Pulmonary manifestations associated with malaria].Revue de pneumologie clinique, , Volume: 54, Issue:6, 1998
[The proper use of antimalarial drugs currently available].Bulletin de la Societe de pathologie exotique (1990), , Volume: 91, Issue:5 Pt 1-2, 1998
In vitro susceptibility of Gabonese wild isolates of Plasmodium falciparum to artemether, and comparison with chloroquine, quinine, halofantrine and amodiaquine.Parasitology, , Volume: 117 ( Pt 6), 1998
[Relapse of Plasmodium falciparum malaria after the return from the Ivory Coast. Type R1 halofantrine resistance or successive infections by 2 different strains?].Presse medicale (Paris, France : 1983), , Oct-17, Volume: 27, Issue:31, 1998
Is halofantrine still advisable in malaria attacks?Annals of tropical medicine and parasitology, , Volume: 91, Issue:7, 1997
[The treatment of malaria].Nederlands tijdschrift voor geneeskunde, , Sep-13, Volume: 141, Issue:37, 1997
Plasmodium falciparum: evaluation of lactate dehydrogenase in monitoring therapeutic responses to standard antimalarial drugs in Nigeria.Experimental parasitology, , Volume: 87, Issue:3, 1997
Recrudescence of Plasmodium falciparum malaria contracted in Lombok, Indonesia after quinine/doxycycline and mefloquine: case report.The New Zealand medical journal, , Jul-11, Volume: 110, Issue:1047, 1997
Supportive pentoxifylline in falciparum malaria: no effect on tumor necrosis factor alpha levels or clinical outcome: a prospective, randomized, placebo-controlled study.The American journal of tropical medicine and hygiene, , Volume: 56, Issue:4, 1997
Halofantrine and primaquine for radical cure of malaria in Irian Jaya, Indonesia.Annals of tropical medicine and parasitology, , Volume: 91, Issue:1, 1997
Halofantrine in G-6 PD deficiency.The Journal of the Association of Physicians of India, , Volume: 45, Issue:11, 1997
[Malaria in expatriates in Africa. 154 cases. Clinical problems and therapeutic difficulties].Presse medicale (Paris, France : 1983), , Feb-15, Volume: 26, Issue:4, 1997
Efficacy of low-dose halofantrine for second treatment of uncomplicated falciparum malaria.Lancet (London, England), , Jan-25, Volume: 349, Issue:9047, 1997
Cardiac effects of standard-dose halofantrine therapy.The American journal of tropical medicine and hygiene, , Volume: 54, Issue:3, 1996
A clinical trial with halofantrine on patients with falciparum malaria in Colombia.Bulletin of the World Health Organization, , Volume: 74, Issue:6, 1996
Electrocardiographic changes and halofantrine plasma level during acute falciparum malaria.The American journal of tropical medicine and hygiene, , Volume: 54, Issue:3, 1996
Evaluation of the safety and efficacy of micronized halofantrine in the treatment of semi-immune patients with acute, Plasmodium falciparum malaria.Annals of tropical medicine and parasitology, , Volume: 90, Issue:5, 1996
Antimalarial drugs reduce cytoadherence and rosetting Plasmodium falciparum.The Journal of infectious diseases, , Volume: 173, Issue:3, 1996
[The halofantrine treatment of Plasmodium falciparum malaria. Clinical experience].Anales espanoles de pediatria, , Volume: 44, Issue:2, 1996
In vivo efficacy of chloroquine, halofantrine, pyrimethamine-sulfadoxine and qinghaosu (artesunate) in the treatment of malaria in Calabar, Nigeria.The Central African journal of medicine, , Volume: 42, Issue:4, 1996
[Diagnostic and prognostic importance of laboratory tests in malaria in airports. Study of six recent cases].Pathologie-biologie, , Volume: 44, Issue:4, 1996
[Electrocardiographic changes due to halofantrine in the treatment of malaria: therapeutic implications].Bulletin de l'Academie nationale de medecine, , Volume: 180, Issue:1, 1996
A randomised controlled trial to assess the relative efficacy of chloroquine, amodiaquine, halofantrine and Fansidar in the treatment of uncomplicated malaria in children.East African medical journal, , Volume: 73, Issue:3, 1996
Activity of azithromycin as a blood schizonticide against rodent and human plasmodia in vivo.The American journal of tropical medicine and hygiene, , Volume: 52, Issue:2, 1995
[Plasma levels of halofantrine during two therapeutic sessions at a 7 day interval].Presse medicale (Paris, France : 1983), , Jun-17, Volume: 24, Issue:22, 1995
New antimalarials. A risk-benefit analysis.Drug safety, , Volume: 12, Issue:4, 1995
Halofantrine in the treatment of falciparum malaria.Indian journal of malariology, , Volume: 32, Issue:1, 1995
Halofantrine pharmacokinetics in Kenyan children with non-severe and severe malaria.British journal of clinical pharmacology, , Volume: 39, Issue:3, 1995
A case of dual chloroquine and halofantrine treatment failure in Zimbabwe.The Central African journal of medicine, , Volume: 41, Issue:10, 1995
Pharmacokinetics of an extended-dose halofantrine regimen in patients with malaria and in healthy volunteers.Clinical pharmacology and therapeutics, , Volume: 57, Issue:5, 1995
Pharmacology and pharmacokinetics of new antimalarials.Medecine tropicale : revue du Corps de sante colonial, , Volume: 55, Issue:4 Suppl, 1995
Efficacy of halofantrine in the treatment of uncomplicated falciparum malaria.East African medical journal, , Volume: 72, Issue:12, 1995
Plasmodium falciparum and Plasmodium vivax: lactate dehydrogenase activity and its application for in vitro drug susceptibility assay.Experimental parasitology, , Volume: 80, Issue:2, 1995
Quinine resistant falciparum malaria acquired in east Africa.Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ), , Volume: 46, Issue:1, 1995
Efficacy and tolerance of extended-dose halofantrine for drug-resistant falciparum malaria in Thailand.The American journal of tropical medicine and hygiene, , Volume: 50, Issue:2, 1994
Selection for mefloquine resistance in Plasmodium falciparum is linked to amplification of the pfmdr1 gene and cross-resistance to halofantrine and quinine.Proceedings of the National Academy of Sciences of the United States of America, , Feb-01, Volume: 91, Issue:3, 1994
In vivo sensitivity of Plasmodium falciparum to halofantrine hydrochloride in Burkina Faso.The American journal of tropical medicine and hygiene, , Volume: 50, Issue:1, 1994
[Malaria prophylaxis: recommendations adapted again].Nederlands tijdschrift voor geneeskunde, , Aug-20, Volume: 138, Issue:34, 1994
Clinical efficacy and pharmacokinetics of micronized halofantrine for the treatment of acute uncomplicated falciparum malaria in nonimmune patients.The American journal of tropical medicine and hygiene, , Volume: 51, Issue:2, 1994
[Plasmodium falciparum malaria resistant to halofantrine in Madagascar. A case].Presse medicale (Paris, France : 1983), , Mar-26, Volume: 23, Issue:12, 1994
High dose chloroquine versus micronized halofantrine in chloroquine-resistant Plasmodium falciparum malaria.The Journal of antimicrobial chemotherapy, , Volume: 33, Issue:4, 1994
Recrudescence of falciparum malaria following treatment with halofantrine.Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases, , Volume: 68, Issue:4, 1994
Comparison of micronized halofantrine with chloroquine-antibiotic combinations for treating Plasmodium falciparum malaria in adults from Gabon.The American journal of tropical medicine and hygiene, , Volume: 50, Issue:6, 1994
Halofantrine in acute malaria.The Journal of the Association of Physicians of India, , Volume: 42, Issue:5, 1994
Clinical pharmacokinetics of halofantrine.Clinical pharmacokinetics, , Volume: 27, Issue:2, 1994
Comparison of capillary whole blood, venous whole blood, and plasma concentrations of mefloquine, halofantrine, and desbutyl-halofantrine measured by high-performance liquid chromatography.The American journal of tropical medicine and hygiene, , Volume: 51, Issue:6, 1994
[Malaria prophylaxis in travellers: the radical halofantrine cure after returning from an endemic zone should be abandoned].Medecine tropicale : revue du Corps de sante colonial, , Volume: 54, Issue:2, 1994
Halofantrine in acute malaria.The Journal of the Association of Physicians of India, , Volume: 42, Issue:5, 1994
Halofantrine treatment of Plasmodium falciparum malaria.Annals of internal medicine, , Jan-15, Volume: 120, Issue:2, 1994
[A case of Plasmodium falciparum malaria successfully treated with halofantrine].Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases, , Volume: 68, Issue:3, 1994
[Ventricular arrhythmia and halofantrine intake. Probable deleterious effect. Apropos of 3 cases].Bulletin de la Societe de pathologie exotique (1990), , Volume: 86, Issue:5, 1993
Efficacy and safety of halofantrine in acute malaria.The Journal of the Association of Physicians of India, , Volume: 41, Issue:8, 1993
[Difficulties of diagnosis and treatment of malaria outbreaks in Europeans living in Burkina Faso].Bulletin de la Societe de pathologie exotique (1990), , Volume: 86, Issue:5, 1993
Cardiac effect of halofantrine.Lancet (London, England), , Aug-21, Volume: 342, Issue:8869, 1993
Halofantrine sensitivity.Lancet (London, England), , Jul-03, Volume: 342, Issue:8862, 1993
Falciparum malaria: differential effects of antimalarial drugs on ex vivo parasite viability during the critical early phase of therapy.The American journal of tropical medicine and hygiene, , Volume: 49, Issue:1, 1993
Clinical trials with halofantrine in acute uncomplicated falciparum malaria in Thailand.The Southeast Asian journal of tropical medicine and public health, , Volume: 24, Issue:1, 1993
[Antimalarial measures in expatriates in the Congo. Trends 1989-1992].Annales de la Societe belge de medecine tropicale, , Volume: 73, Issue:2, 1993
Halofantrine resistance in African countries.Lancet (London, England), , May-15, Volume: 341, Issue:8855, 1993
Cardiac effects of antimalarial treatment with halofantrine.Lancet (London, England), , Apr-24, Volume: 341, Issue:8852, 1993
Halofantrine--an alternative treatment for malaria.Drug and therapeutics bulletin, , Jul-19, Volume: 31, Issue:15, 1993
Halofantrine versus mefloquine in treatment of multidrug-resistant falciparum malaria.Lancet (London, England), , Apr-24, Volume: 341, Issue:8852, 1993
Artemisinin compounds in treatment of malaria.Lancet (London, England), , Apr-17, Volume: 341, Issue:8851, 1993
Fast emergence of Plasmodium falciparum resistance to halofantrine.Lancet (London, England), , Apr-03, Volume: 341, Issue:8849, 1993
Amplification of pfmdr 1 associated with mefloquine and halofantrine resistance in Plasmodium falciparum from Thailand.Molecular and biochemical parasitology, , Volume: 57, Issue:1, 1993
[Halofantrine in the treatment of imported malaria in nonimmune travelers].Deutsche medizinische Wochenschrift (1946), , Feb-26, Volume: 118, Issue:8, 1993
Halofantrine resistance in African countries.Lancet (London, England), , May-15, Volume: 341, Issue:8855, 1993
Halofantrine: a new substance for treatment of multidrug-resistant malaria.The Clinical investigator, , Volume: 71, Issue:1, 1993
Pharmacokinetics, efficacy and toxicity of parenteral halofantrine in uncomplicated malaria.British journal of clinical pharmacology, , Volume: 36, Issue:6, 1993
Efficacy of micronized halofantrine in semi-immune patients with acute uncomplicated falciparum malaria in Cameroon.Antimicrobial agents and chemotherapy, , Volume: 37, Issue:9, 1993
Drug alert: halofantrine.Releve epidemiologique hebdomadaire, , Sep-10, Volume: 68, Issue:37, 1993
Halofantrine in the treatment of acute malaria: a multi-centre study in 268 patients.Current medical research and opinion, , Volume: 13, Issue:3, 1993
Postexposure administration of halofantrine for the prevention of malaria.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, , Volume: 17, Issue:4, 1993
Susceptibility of Plasmodium falciparum strains to mefloquine in an urban area in Senegal.Bulletin of the World Health Organization, , Volume: 70, Issue:3, 1992
Proposals for a new therapeutic strategy for simple Plasmodium falciparum malaria attacks in Cameroon.Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ), , Volume: 43, Issue:2, 1992
[Efficacy of radical treatment with halofantrine on the prevention of imported Plasmodium falciparum malaria].Annales de la Societe belge de medecine tropicale, , Volume: 72, Issue:4, 1992
Efficacy, safety and acceptability of halofantrine in the treatment of acute Plasmodium falciparum malaria in African children (Gabon).Journal of tropical pediatrics, , Volume: 38, Issue:1, 1992
Emergence of multidrug-resistant Plasmodium falciparum in Thailand: in vitro tracking.The American journal of tropical medicine and hygiene, , Volume: 47, Issue:1, 1992
[Treatment of malaria in children in France].Pediatrie, , Volume: 47, Issue:5, 1992
[Parasitemia in Plasmodium falciparum malarial attacks in children].Presse medicale (Paris, France : 1983), , Nov-14, Volume: 21, Issue:38, 1992
Comparative trial on the response of Plasmodium falciparum to halofantrine and mefloquine in Trat Province, eastern Thailand.The Southeast Asian journal of tropical medicine and public health, , Volume: 23, Issue:1, 1992
In vitro activity of halofantrine and its relationship to other standard antimalarial drugs against African isolates and clones of Plasmodium falciparum.The American journal of tropical medicine and hygiene, , Volume: 47, Issue:4, 1992
The efficacy of halofantrine in the treatment of acute malaria in nonimmune travelers.The American journal of tropical medicine and hygiene, , Volume: 47, Issue:1, 1992
The treatment of falciparum malaria in children with halofantrine suspension.Memorias do Instituto Oswaldo Cruz, , Volume: 87 Suppl 3, 1992
Halofantrine and acute intravascular haemolysis.Lancet (London, England), , Oct-10, Volume: 340, Issue:8824, 1992
Type RI resistance to halofantrine in West Africa.Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ), , Volume: 42, Issue:4, 1991
[Trial of halofantrine in the treatment of malaria attacks by Plasmodium falciparum in Dakar (Senegal)].Bulletin de la Societe de pathologie exotique (1990), , Volume: 84, Issue:3, 1991
[Malaria in the republic of São Tomé and Principe. Epidemiologic evaluation and chemoresistance of P. falciparum].Bulletin de la Societe de pathologie exotique (1990), , Volume: 84, Issue:3, 1991
Halofantrine in the treatment of acute uncomplicated falciparum malaria in the Philippines.The Southeast Asian journal of tropical medicine and public health, , Volume: 22, Issue:3, 1991
Pharmacokinetics of halofantrine and n-desbutylhalofantrine in patients with falciparum malaria following a multiple dose regimen of halofantrine.European journal of clinical pharmacology, , Volume: 41, Issue:2, 1991
Halofantrine for the treatment of mefloquine chemoprophylaxis failures in Plasmodium falciparum infections.The American journal of tropical medicine and hygiene, , Volume: 45, Issue:4, 1991
Comparative cardiac effects of halofantrine and chloroquine plus chlorpheniramine in children with acute uncomplicated falciparum malaria.Transactions of the Royal Society of Tropical Medicine and Hygiene, , Volume: 93, Issue:1
Problems in the therapy of mixed malarial infections: a case of infection with Plasmodium falciparum and P. malariae treated with mefloquine and halofantrine.Transactions of the Royal Society of Tropical Medicine and Hygiene, , Volume: 87, Issue:6
Halofantrine versus quinine-Fansidar combination in the treatment of post-chloroquine falciparum parasitaemia.Papua and New Guinea medical journal, , Volume: 41, Issue:3-4
Decreasing chloroquine resistance in Plasmodium falciparum isolates from Gabon.Transactions of the Royal Society of Tropical Medicine and Hygiene, , Volume: 94, Issue:5
[Congenital malaria. A case observed in twins born to an asymptomatic mother].Presse medicale (Paris, France : 1983), , Volume: 23, Issue:17
[Drug resistant tropical malaria in the Republic of Guinea (West Africa)].Meditsinskaia parazitologiia i parazitarnye bolezni, , Issue:2
Choice of therapy for imported cases of falciparum malaria in children: a retrospective study of 100 cases seen in Marseilles, France.Transactions of the Royal Society of Tropical Medicine and Hygiene, , Volume: 87, Issue:1
Halofantrine treatment of uncomplicated falciparum malaria with high parasitaemia.Transactions of the Royal Society of Tropical Medicine and Hygiene, , Volume: 87, Issue:1
Comparative efficacy of halofantrine, chloroquine and sulfadoxine-pyrimethamine for treatment of acute uncomplicated falciparum malaria in Nigerian children.Transactions of the Royal Society of Tropical Medicine and Hygiene, , Volume: 91, Issue:1
Cardiac complications of halofantrine: a prospective study of 20 patients.Transactions of the Royal Society of Tropical Medicine and Hygiene, , Volume: 89, Issue:4
[Current aspects of malaria in expatriates in the Central African Republic].Medecine tropicale : revue du Corps de sante colonial, , Volume: 51, Issue:4
[Lipid profile during specific malaria therapy in Gabonese children].Sante (Montrouge, France), , Volume: 5, Issue:2
Severe cardiac toxicity due to halofantrine: importance of underlying heart disease.Journal of travel medicine, , Volume: 9, Issue:4
Halofantrine given with food for falciparum malaria.Transactions of the Royal Society of Tropical Medicine and Hygiene, , Volume: 86, Issue:3
Malaria: treatment.Journal of the Royal College of Physicians of London, , Volume: 32, Issue:3
[How to perform and interpret the results of a chemoresistance test of Plasmodium falciparum in malaria patients in a tropical region].Sante (Montrouge, France), , Volume: 6, Issue:3
A new micronized formulation of halofantrine hydrochloride in the treatment of acute Plasmodium falciparum malaria.Transactions of the Royal Society of Tropical Medicine and Hygiene, , Volume: 87, Issue:4
Atovaquone plus proguanil versus halofantrine for the treatment of imported acute uncomplicated Plasmodium falciparum malaria in non-immune adults: a randomized comparative trial.The American journal of tropical medicine and hygiene, , Volume: 63, Issue:5-6
Comparative efficacy of chloroquine plus chlorpheniramine and halofantrine in acute uncomplicated falciparum malaria in Nigerian children.Transactions of the Royal Society of Tropical Medicine and Hygiene, , Volume: 92, Issue:4
Cardiac effects of halofantrine in children suffering from acute uncomplicated falciparum malaria.Transactions of the Royal Society of Tropical Medicine and Hygiene, , Volume: 92, Issue:4
Treatment of murine cerebral malaria by artemisone in combination with conventional antimalarial drugs: antiplasmodial effects and immune responses.Antimicrobial agents and chemotherapy, , Volume: 58, Issue:8, 2014
Recrudescence of Plasmodium falciparum malaria contracted in Lombok, Indonesia after quinine/doxycycline and mefloquine: case report.The New Zealand medical journal, , Jul-11, Volume: 110, Issue:1047, 1997
[Treatment of malaria in children in France].Pediatrie, , Volume: 47, Issue:5, 1992
Efficacy and safety of halofantrine in Pakistani children and adults with malaria caused by P. falciparum and P. vivax.The Southeast Asian journal of tropical medicine and public health, , Volume: 37, Issue:4, 2006
Genetic and biochemical aspects of drug resistance in malaria parasites.Current drug targets. Infectious disorders, , Volume: 4, Issue:1, 2004
[Epidemiological and therapeutic aspects of plasmodial infection from Plasmodium vivax].Medecine tropicale : revue du Corps de sante colonial, , Volume: 60, Issue:4, 2000
Assessing drug sensitivity of Plasmodium vivax to halofantrine or choroquine in southern, central Vietnam using an extended 28-day in vivo test and polymerase chain reaction genotyping.The American journal of tropical medicine and hygiene, , Volume: 62, Issue:6, 2000
[The proper use of antimalarial drugs currently available].Bulletin de la Societe de pathologie exotique (1990), , Volume: 91, Issue:5 Pt 1-2, 1998
Halofantrine in G-6 PD deficiency.The Journal of the Association of Physicians of India, , Volume: 45, Issue:11, 1997
Halofantrine and primaquine for radical cure of malaria in Irian Jaya, Indonesia.Annals of tropical medicine and parasitology, , Volume: 91, Issue:1, 1997
[The treatment of malaria].Nederlands tijdschrift voor geneeskunde, , Sep-13, Volume: 141, Issue:37, 1997
Prolongation of the QT interval observed in a Japanese patient with vivax malaria following treatment with halofantrine.Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases, , Volume: 69, Issue:12, 1995
Treatment of chloroquine-resistant Plasmodium vivax with chloroquine and primaquine or halofantrine.The Journal of infectious diseases, , Volume: 171, Issue:6, 1995
Plasmodium falciparum and Plasmodium vivax: lactate dehydrogenase activity and its application for in vitro drug susceptibility assay.Experimental parasitology, , Volume: 80, Issue:2, 1995
Sudden deaths while on halofantrine treatments--a report of two cases from peshawar.JPMA. The Journal of the Pakistan Medical Association, , Volume: 44, Issue:5, 1994
Halofantrine in acute malaria.The Journal of the Association of Physicians of India, , Volume: 42, Issue:5, 1994
Halofantrine in acute malaria.The Journal of the Association of Physicians of India, , Volume: 42, Issue:5, 1994
Postexposure administration of halofantrine for the prevention of malaria.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, , Volume: 17, Issue:4, 1993
Halofantrine: a new substance for treatment of multidrug-resistant malaria.The Clinical investigator, , Volume: 71, Issue:1, 1993
[Halofantrine in the treatment of imported malaria in nonimmune travelers].Deutsche medizinische Wochenschrift (1946), , Feb-26, Volume: 118, Issue:8, 1993
Efficacy and safety of halofantrine in acute malaria.The Journal of the Association of Physicians of India, , Volume: 41, Issue:8, 1993
Drug alert: halofantrine.Releve epidemiologique hebdomadaire, , Sep-10, Volume: 68, Issue:37, 1993
Halofantrine in the treatment of acute malaria: a multi-centre study in 268 patients.Current medical research and opinion, , Volume: 13, Issue:3, 1993
The efficacy of halofantrine in the treatment of acute malaria in nonimmune travelers.The American journal of tropical medicine and hygiene, , Volume: 47, Issue:1, 1992
The treatment of falciparum malaria in children with halofantrine suspension.Memorias do Instituto Oswaldo Cruz, , Volume: 87 Suppl 3, 1992
Studies in human malaria; the suppressive action of a phenanthrene amino alcohol, NIH-204 (SN-1796) against sporozoite-induced vivax malaria (St. Elizabeth strain).American journal of hygiene, , Volume: 46, Issue:1, 1947
Cardiac complications of halofantrine: a prospective study of 20 patients.Transactions of the Royal Society of Tropical Medicine and Hygiene, , Volume: 89, Issue:4
Malaria: treatment.Journal of the Royal College of Physicians of London, , Volume: 32, Issue:3
The Inhibition Effect of Triptolide on Human Endometrial Carcinoma Cell Line HEC-1B: a in vitro and in vivo Studies.Asian Pacific journal of cancer prevention : APJCP, , Volume: 16, Issue:11, 2015
Triptolide induces apoptosis in endometrial cancer via a p53‑independent mitochondrial pathway.Molecular medicine reports, , Volume: 9, Issue:1, 2014
Novel target genes responsive to the anti-growth activity of triptolide in endometrial and ovarian cancer cells.Cancer letters, , Nov-28, Volume: 297, Issue:2, 2010
Natural-derived compounds and their mechanisms in potential autosomal dominant polycystic kidney disease (ADPKD) treatment.Clinical and experimental nephrology, , Volume: 25, Issue:11, 2021
Triptolide-containing formulation in patients with autosomal dominant polycystic kidney disease and proteinuria: an uncontrolled trial.American journal of kidney diseases : the official journal of the National Kidney Foundation, , Volume: 63, Issue:6, 2014
Triptolide reduces cyst formation in a neonatal to adult transition Pkd1 model of ADPKD.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, , Volume: 25, Issue:7, 2010
Triptolide reduces cystogenesis in a model of ADPKD.Journal of the American Society of Nephrology : JASN, , Volume: 19, Issue:9, 2008
Four Main Active Ingredients Derived from a Traditional Chinese Medicine Guanxin Shutong Capsule Cause Cardioprotection during Myocardial Ischemia Injury Calcium Overload Suppression.Phytotherapy research : PTR, , Volume: 31, Issue:3, 2017
Sodium tanshinone IIA sulfonate ameliorates ischemia-induced myocardial inflammation and lipid accumulation in Beagle dogs through NLRP3 inflammasome.International journal of cardiology, , Oct-01, Volume: 196, 2015
Tanshinone IIA pretreatment protects myocardium against ischaemia/reperfusion injury through the phosphatidylinositol 3-kinase/Akt-dependent pathway in diabetic rats.Diabetes, obesity & metabolism, , Volume: 12, Issue:4, 2010
Cryptotanshinone, a lipophilic compound of Salvia miltiorrriza root, inhibits TNF-alpha-induced expression of adhesion molecules in HUVEC and attenuates rat myocardial ischemia/reperfusion injury in vivo.European journal of pharmacology, , Jul-01, Volume: 614, Issue:1-3, 2009
Preclinical factors affecting the pharmacokinetic behaviour of tanshinone IIA, an investigational new drug isolated from Salvia miltiorrhiza for the treatment of ischaemic heart diseases.Xenobiotica; the fate of foreign compounds in biological systems, , Volume: 38, Issue:2, 2008
Sodium tanshinone IIA sulfonate protects cardiomyocytes against oxidative stress-mediated apoptosis through inhibiting JNK activation.Journal of cardiovascular pharmacology, , Volume: 51, Issue:4, 2008
[Anti-inflammatory constituents, aloesin and aloemannan in Aloe species and effects of tanshinon VI in Salvia miltiorrhiza on heart].Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, , Volume: 123, Issue:7, 2003
Scavenging effects of salvia miltiorrhiza on free radicals and its protection for myocardial mitochondrial membranes from ischemia-reperfusion injury.Biochemistry and molecular biology international, , Volume: 38, Issue:6, 1996
Safety/Toxicity (281)
| Article | Year |
|---|
Endophytic Bacillus sp. R1 and Its Roles in Assisting Phytoremediation and Alleviating the Toxicity of Aluminum Combined Phenanthrene Contaminations in Brassica napus.
Current microbiology, , Oct-31, Volume: 80, Issue:12 | 2023 |
Integument colour change: Tracking delayed growth of Oppia nitens as a sub-lethal indicator of soil toxicity.
Environmental pollution (Barking, Essex : 1987), , Dec-15, Volume: 339 | 2023 |
Microplastics reduced bioavailability and altered toxicity of phenanthrene to maize (Zea mays L.) through modulating rhizosphere microbial community and maize growth.
Chemosphere, , Volume: 345 | 2023 |
The efficacy and safety of sodium tanshinone ⅡA sulfonate injection in the treatment of unstable angina pectoris: A systematic review and meta-analysis.
PloS one, , Volume: 18, Issue:8 | 2023 |
Recent advances in the pharmacological applications and liver toxicity of triptolide.
Chemico-biological interactions, , Sep-01, Volume: 382 | 2023 |
Cardiac toxicity of phenanthrene depends on developmental stage in Atlantic cod (Gadus morhua).
The Science of the total environment, , Jul-10, Volume: 881 | 2023 |
A comprehensive review on celastrol, triptolide and triptonide: Insights on their pharmacological activity, toxicity, combination therapy, new dosage form and novel drug delivery routes.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 162 | 2023 |
Mechanistic insights into phenanthrene-triggered oxidative stress-associated neurotoxicity, genotoxicity, and behavioral disturbances toward the brandling worm (Eisenia fetida) brain: The need for an ecotoxicological evaluation.
Journal of hazardous materials, , 05-15, Volume: 450 | 2023 |
Investigating the adverse outcome pathways (AOP) of neurotoxicity induced by DBDPE with a combination of in vitro and in silico approaches.
Journal of hazardous materials, , 05-05, Volume: 449 | 2023 |
Triptolide and l-ascorbate palmitate co-loaded micelles for combination therapy of rheumatoid arthritis and side effect attenuation.
Drug delivery, , Volume: 29, Issue:1 | 2022 |
Neuroprotection of Triptolide against Amyloid-Beta1-42-induced toxicity via the Akt/mTOR/p70S6K-mediated Autophagy Pathway.
Anais da Academia Brasileira de Ciencias, , Volume: 94, Issue:2 | 2022 |
ROS-independent cytotoxicity of 9,10-phenanthrenequinone inhibits cell cycle progression and spindle assembly during meiotic maturation in mouse oocytes.
Journal of hazardous materials, , 08-15, Volume: 436 | 2022 |
New mechanism of nephrotoxicity of triptolide: Oxidative stress promotes cGAS-STING signaling pathway.
Free radical biology & medicine, , 08-01, Volume: 188 | 2022 |
Promotion of the biodegradation of phenanthrene adsorbed on microplastics by the functional bacterial consortium QY1 in the presence of humic acid: Bioavailability and toxicity evaluation.
Environmental pollution (Barking, Essex : 1987), , Aug-15, Volume: 307 | 2022 |
Antibiotic pretreatment promotes orally-administered triptolide absorption and aggravates hepatotoxicity and intestinal injury in mice.
Journal of ethnopharmacology, , Jun-28, Volume: 292 | 2022 |
Establishment of cytochrome P450 1a gene-knockout Javanese medaka, Oryzias javanicus, which distinguishes toxicity modes of the polycyclic aromatic hydrocarbons, pyrene and phenanthrene.
Marine pollution bulletin, , Volume: 178 | 2022 |
Remediation of phenanthrene phytotoxicity by the interaction of rice and endophytic fungus P. liquidambaris in practice.
Ecotoxicology and environmental safety, , Apr-15, Volume: 235 | 2022 |
Efficient biodegradation of phenanthrene using Pseudomonas stutzeri LSH-PAH1 with the addition of sophorolipids: Alleviation of biotoxicity and cometabolism studies.
Environmental pollution (Barking, Essex : 1987), , May-15, Volume: 301 | 2022 |
Moderate acidification mitigates the toxic effects of phenanthrene on the mitten crab Eriocheir sinensis.
Chemosphere, , Volume: 294 | 2022 |
Toxic mechanism on phenanthrene-triggered cell apoptosis, genotoxicity, immunotoxicity and activity changes of immunity protein in Eisenia fetida: Combined analysis at cellular and molecular levels.
The Science of the total environment, , May-01, Volume: 819 | 2022 |
Folate-modified triptolide liposomes target activated macrophages for safe rheumatoid arthritis therapy.
Biomaterials science, , Jan-18, Volume: 10, Issue:2 | 2022 |
Microplastics increase the accumulation of phenanthrene in the ovaries of marine medaka (Oryzias melastigma) and its transgenerational toxicity.
Journal of hazardous materials, , 02-15, Volume: 424, Issue:Pt D | 2022 |
Targeting tryptophan metabolism reveals Clematichinenoside AR alleviates triptolide-induced hepatotoxicity.
Journal of pharmaceutical and biomedical analysis, , Jan-20, Volume: 208 | 2022 |
Developmental toxicity of cryptotanshinone on the early-life stage of zebrafish development.
Human & experimental toxicology, , Volume: 40, Issue:12_suppl | 2021 |
Role of MicroRNA-155 in Triptolide-induced hepatotoxicity via the Nrf2-Dependent pathway.
Journal of ethnopharmacology, , Dec-05, Volume: 281 | 2021 |
Biodegradation and detoxification of phenanthrene in in vitro and in vivo conditions by a newly isolated ligninolytic fungus Coriolopsis byrsina strain APC5 and characterization of their metabolites for environmental safety.
Environmental science and pollution research international, , Volume: 29, Issue:41 | 2022 |
Acute and chronic toxicity of microcystin-LR and phenanthrene alone or in combination to the cladoceran (Daphnia magna).
Ecotoxicology and environmental safety, , Sep-01, Volume: 220 | 2021 |
Toxic mechanism on phenanthrene-induced cytotoxicity, oxidative stress and activity changes of superoxide dismutase and catalase in earthworm (Eisenia foetida): A combined molecular and cellular study.
Journal of hazardous materials, , 09-15, Volume: 418 | 2021 |
Toxicity of two representative petroleum hydrocarbons, toluene and phenanthrene, to five Atlantic coral species.
Marine pollution bulletin, , Volume: 169 | 2021 |
Toxicity evaluation of the metabolites derived from the degradation of phenanthrene by one of a soil ubiquitous PAHs-degrading strain Rhodococcus qingshengii FF.
Journal of hazardous materials, , 08-05, Volume: 415 | 2021 |
Gamma-aminobutyric acid improves phenanthrene phytotoxicity tolerance in cucumber through the glutathione-dependent system of antioxidant defense.
Ecotoxicology and environmental safety, , Jul-01, Volume: 217 | 2021 |
Effects of polystyrene microplastics on uptake and toxicity of phenanthrene in soybean.
The Science of the total environment, , Aug-20, Volume: 783 | 2021 |
Cryptotanshinone Ameliorates Doxorubicin-Induced Cardiotoxicity by Targeting Akt-GSK-3β-mPTP Pathway In Vitro.
Molecules (Basel, Switzerland), , Mar-08, Volume: 26, Issue:5 | 2021 |
Triptolide and atorvastatin synergistically promote hepatotoxicity in cultured hepatocytes and female Sprague-Dawley rats by inhibiting pregnane X receptor-mediated transcriptional activation of CYP3A4.
Toxicology letters, , May-15, Volume: 342 | 2021 |
Effects of Phenanthrene Exposure on Cholesterol Homeostasis and Cardiotoxicity in Zebrafish Embryos.
Environmental toxicology and chemistry, , Volume: 40, Issue:6 | 2021 |
Triptolide delivery: Nanotechnology-based carrier systems to enhance efficacy and limit toxicity.
Pharmacological research, , Volume: 165 | 2021 |
Immune toxicity of phenanthrene and its combined effects of white spot syndrome virus on the survival of kuruma shrimp (Penaeus Japonicus).
Ecotoxicology and environmental safety, , Jan-15, Volume: 208 | 2021 |
Synthesis of glutathione as a central aspect of PAH toxicity in liver cells: A comparison between phenanthrene, Benzo[b]Fluoranthene and their mixtures.
Ecotoxicology and environmental safety, , Jan-15, Volume: 208 | 2021 |
Construction of a pH-responsive, ultralow-dose triptolide nanomedicine for safe rheumatoid arthritis therapy.
Acta biomaterialia, , Volume: 121 | 2021 |
[Arctiin antagonizes triptolide-induced renal toxicity in rats via anti-inflammatory pathway].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University, , Oct-30, Volume: 40, Issue:10 | 2020 |
Measured and predicted acute toxicity of phenanthrene and MC252 crude oil to vertically migrating deep-sea crustaceans.
Environmental science and pollution research international, , Volume: 27, Issue:36 | 2020 |
Catalpol coordinately regulates phase I and II detoxification enzymes of Triptolide through CAR and NRF2 pathways to reduce Triptolide-induced hepatotoxicity.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 129 | 2020 |
Circadian clock regulates hepatotoxicity of Tripterygium wilfordii through modulation of metabolism.
The Journal of pharmacy and pharmacology, , Volume: 72, Issue:12 | 2020 |
Attenuation of doxorubicin-induced cardiotoxicity by
Aging, , 05-26, Volume: 12, Issue:10 | 2020 |
TFEB-NF-κB inflammatory signaling axis: a novel therapeutic pathway of Dihydrotanshinone I in doxorubicin-induced cardiotoxicity.
Journal of experimental & clinical cancer research : CR, , May-24, Volume: 39, Issue:1 | 2020 |
Cisplatin nephrotoxicity is induced via poly(ADP-ribose) polymerase activation in adult zebrafish and mice.
American journal of physiology. Regulatory, integrative and comparative physiology, , 05-01, Volume: 318, Issue:5 | 2020 |
Gut microbiota protects from triptolide-induced hepatotoxicity: Key role of propionate and its downstream signalling events.
Pharmacological research, , Volume: 155 | 2020 |
Sodium tanshinone IIA sulfonate protects against Aβ-induced cell toxicity through regulating Aβ process.
Journal of cellular and molecular medicine, , Volume: 24, Issue:6 | 2020 |
Molecularly Engineering Triptolide with Aptamers for High Specificity and Cytotoxicity for Triple-Negative Breast Cancer.
Journal of the American Chemical Society, , 02-12, Volume: 142, Issue:6 | 2020 |
miR398 is involved in the relief of phenanthrene-induced oxidative toxicity in wheat roots.
Environmental pollution (Barking, Essex : 1987), , Volume: 258 | 2020 |
Combined treatment of melatonin and sodium tanshinone IIA sulfonate reduced the neurological and cardiovascular toxicity induced by deltamethrin in zebrafish.
Chemosphere, , Volume: 243 | 2020 |
Low level of polystyrene microplastics decreases early developmental toxicity of phenanthrene on marine medaka (Oryzias melastigma).
Journal of hazardous materials, , 03-05, Volume: 385 | 2020 |
Key role of organic cation transporter 2 for the nephrotoxicity effect of triptolide in rheumatoid arthritis.
International immunopharmacology, , Volume: 77 | 2019 |
Triptolide-loaded nanoparticles targeting breast cancer in vivo with reduced toxicity.
International journal of pharmaceutics, , Dec-15, Volume: 572 | 2019 |
[Study on difference of liver toxicity and its molecular mechanisms caused by Tripterygium wilfordii multiglycoside and equivalent amount of triptolid in rats].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, , Volume: 44, Issue:16 | 2019 |
Combined toxic effects of microcystin-LR and phenanthrene on growth and antioxidant system of duckweed (Lemna gibba L.).
Ecotoxicology and environmental safety, , Dec-15, Volume: 185 | 2019 |
Toxic effects of triptolide on adrenal steroidogenesis in H295R cells and female rats.
Journal of biochemical and molecular toxicology, , Volume: 33, Issue:11 | 2019 |
Mitochondria-dependent apoptosis in triptolide-induced hepatotoxicity is associated with the Drp1 activation.
Toxicology mechanisms and methods, , Volume: 30, Issue:2 | 2020 |
Understanding the cardiac toxicity of the anthropogenic pollutant phenanthrene on the freshwater indicator species, the brown trout (Salmo trutta): From whole heart to cardiomyocytes.
Chemosphere, , Volume: 239 | 2020 |
The role of inflammasome activation in Triptolide-induced acute liver toxicity.
International immunopharmacology, , Volume: 75 | 2019 |
Triptolide-induced hepatotoxicity via apoptosis and autophagy in zebrafish.
Journal of applied toxicology : JAT, , Volume: 39, Issue:11 | 2019 |
Triptolide induces toxicity in inner ear stem cells via promoting DNA damage.
Toxicology in vitro : an international journal published in association with BIBRA, , Volume: 61 | 2019 |
Partitioning of chemical contaminants to microplastics: Sorption mechanisms, environmental distribution and effects on toxicity and bioaccumulation.
Environmental pollution (Barking, Essex : 1987), , Volume: 252, Issue:Pt B | 2019 |
Protective Effect of Vitamin C on Triptolide-induced Acute Hepatotoxicity in Mice through mitigation of oxidative stress.
Anais da Academia Brasileira de Ciencias, , Jun-19, Volume: 91, Issue:2 | 2019 |
High-content analysis boosts identification of the initial cause of triptolide-induced hepatotoxicity.
Journal of applied toxicology : JAT, , Volume: 39, Issue:9 | 2019 |
Phenanthrene, but not its isomer anthracene, effectively activates both human and mouse nuclear receptor constitutive androstane receptor (CAR) and induces hepatotoxicity in mice.
Toxicology and applied pharmacology, , 09-01, Volume: 378 | 2019 |
Neurodevelopmental toxicity assessments of alkyl phenanthrene and Dechlorane Plus co-exposure in zebrafish.
Ecotoxicology and environmental safety, , Sep-30, Volume: 180 | 2019 |
In vivo protective effects of chlorogenic acid against triptolide-induced hepatotoxicity and its mechanism.
Pharmaceutical biology, , Volume: 56, Issue:1 | 2018 |
MicroRNA expression, targeting, release dynamics and early-warning biomarkers in acute cardiotoxicity induced by triptolide in rats.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 111 | 2019 |
The Study of Cellular Mechanism of Triptolide in the Treatment of Cancer, Bone Loss and Cardiovascular Disease and Triptolide's Toxicity.
Current stem cell research & therapy, , Volume: 15, Issue:1 | 2020 |
The drought and high wet soil condition impact on PAH (phenanthrene) toxicity towards nitrifying bacteria.
Journal of hazardous materials, , 04-15, Volume: 368 | 2019 |
Catalpol and panax notoginseng saponins synergistically alleviate triptolide-induced hepatotoxicity through Nrf2/ARE pathway.
Toxicology in vitro : an international journal published in association with BIBRA, , Volume: 56 | 2019 |
Increased ZnO nanoparticle toxicity to wheat upon co-exposure to phenanthrene.
Environmental pollution (Barking, Essex : 1987), , Volume: 247 | 2019 |
Selenium alleviates phytotoxicity of phenanthrene and pyrene in Alternanthera Philoxeroides.
International journal of phytoremediation, , Volume: 20, Issue:14 | 2018 |
A new perspective of triptolide-associated hepatotoxicity: Liver hypersensitivity upon LPS stimulation.
Toxicology, , 02-15, Volume: 414 | 2019 |
Drp1-associated mitochondrial dysfunction and mitochondrial autophagy: a novel mechanism in triptolide-induced hepatotoxicity.
Cell biology and toxicology, , Volume: 35, Issue:3 | 2019 |
The effect of pH on the acute toxicity of phenanthrene in a marine microalgae Chlorella salina.
Scientific reports, , 12-04, Volume: 8, Issue:1 | 2018 |
Galactosylated chitosan triptolide nanoparticles for overcoming hepatocellular carcinoma: Enhanced therapeutic efficacy, low toxicity, and validated network regulatory mechanisms.
Nanomedicine : nanotechnology, biology, and medicine, , Volume: 15, Issue:1 | 2019 |
Possible role of hepatic macrophage recruitment and activation in triptolide-induced hepatotoxicity.
Toxicology letters, , Dec-15, Volume: 299 | 2018 |
Poly(ADP-ribosyl)ated PXR is a critical regulator of acetaminophen-induced hepatotoxicity.
Cell death & disease, , 07-26, Volume: 9, Issue:8 | 2018 |
Cytotoxicity of Air Pollutant 9,10-Phenanthrenequinone: Role of Reactive Oxygen Species and Redox Signaling.
BioMed research international, , Volume: 2018 | 2018 |
Metabolic alterations in triptolide-induced acute hepatotoxicity.
Biomedical chromatography : BMC, , Volume: 32, Issue:10 | 2018 |
Licorice root extract and magnesium isoglycyrrhizinate protect against triptolide-induced hepatotoxicity via up-regulation of the Nrf2 pathway.
Drug delivery, , Volume: 25, Issue:1 | 2018 |
Isoliquiritigenin protects against triptolide-induced hepatotoxicity in mice through Nrf2 activation.
Die Pharmazie, , Jul-07, Volume: 71, Issue:7 | 2016 |
Atractylodes lancea rhizome water extract reduces triptolide-induced toxicity and enhances anti-inflammatory effects.
Chinese journal of natural medicines, , Volume: 15, Issue:12 | 2017 |
Triptolide-induced hepatotoxicity can be alleviated when combined with Panax notoginseng saponins and Catapol.
Journal of ethnopharmacology, , Mar-25, Volume: 214 | 2018 |
Protective effects of silymarin on triptolide-induced acute hepatotoxicity in rats.
Molecular medicine reports, , Volume: 17, Issue:1 | 2018 |
Characterization of Triptolide-Induced Hepatotoxicity by Imaging and Transcriptomics in a Novel Zebrafish Model.
Toxicological sciences : an official journal of the Society of Toxicology, , 10-01, Volume: 159, Issue:2 | 2017 |
Cytotoxicity of anticancer drugs and PJ-34 (poly(ADP-ribose)polymerase-1 (PARP-1) inhibitor) on HL-60 and Jurkat cells.
Advances in clinical and experimental medicine : official organ Wroclaw Medical University, , Volume: 26, Issue:3 | |
A novel topoisomerase 2a inhibitor, cryptotanshinone, suppresses the growth of PC3 cells without apparent cytotoxicity.
Toxicology and applied pharmacology, , 09-01, Volume: 330 | 2017 |
Inhibition of Poly(ADP-ribose) Polymerase-1 Enhances Gene Expression of Selected Sirtuins and APP Cleaving Enzymes in Amyloid Beta Cytotoxicity.
Molecular neurobiology, , Volume: 55, Issue:6 | 2018 |
UPLC/ESI-QTOF-MS-based metabolomics survey on the toxicity of triptolide and detoxication of licorice.
Chinese journal of natural medicines, , Volume: 15, Issue:6 | 2017 |
Neurotoxicity of alkylated polycyclic aromatic compounds in human neuroblastoma cells.
Journal of toxicology and environmental health. Part A, , Volume: 80, Issue:5 | 2017 |
Self-protection against triptolide-induced toxicity in human hepatic cells via Nrf2-ARE-NQO1 pathway.
Chinese journal of integrative medicine, , Volume: 23, Issue:12 | 2017 |
Toxicity of triptolide and the molecular mechanisms involved.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 90 | 2017 |
Potentially reversible acute cerebellar toxicity associated with Minnelide.
Neuroradiology, , Volume: 59, Issue:4 | 2017 |
Effect of multi-walled carbon nanotubes on phytotoxicity of sediments contaminated by phenanthrene and cadmium.
Chemosphere, , Volume: 172 | 2017 |
Enhancement of the bioavailability of a novel anticancer compound (acetyltanshinone IIA) by encapsulation within mPEG-PLGA nanoparticles: a study of formulation optimization, toxicity, and pharmacokinetics.
Oncotarget, , Feb-14, Volume: 8, Issue:7 | 2017 |
Triptolide Induces hepatotoxicity via inhibition of CYP450s in Rat liver microsomes.
BMC complementary and alternative medicine, , Jan-05, Volume: 17, Issue:1 | 2017 |
Effects of nanoplastics and microplastics on toxicity, bioaccumulation, and environmental fate of phenanthrene in fresh water.
Environmental pollution (Barking, Essex : 1987), , Volume: 219 | 2016 |
Long-term Use (10)
| Article | Year |
|---|
Fosdagrocorat (PF-04171327) versus prednisone or placebo in rheumatoid arthritis: a randomised, double-blind, multicentre, phase IIb study.
RMD open, , Volume: 5, Issue:1 | 2019 |
Pharmacokinetics and pharmacodynamics of orally administered acetylenic tricyclic bis(cyanoenone), a highly potent Nrf2 activator with a reversible covalent mode of action.
Biochemical and biophysical research communications, , Sep-25, Volume: 465, Issue:3 | 2015 |
Tripchlorolide improves age-associated cognitive deficits by reversing hippocampal synaptic plasticity impairment and NMDA receptor dysfunction in SAMP8 mice.
Behavioural brain research, , Jan-01, Volume: 258 | 2014 |
Improved retinal ganglion cell survival through retinal microglia suppression by a chinese herb extract, triptolide, in the DBA/2J mouse model of glaucoma.
Ocular immunology and inflammation, , Volume: 21, Issue:5 | 2013 |
Disseminated cutaneous Kaposi sarcoma in a patient receiving triptolide/tripdiolide for rheumatoid arthritis.
Medical science monitor : international medical journal of experimental and clinical research, , Volume: 18, Issue:8 | 2012 |
[Effects of triptolide on hypothalamic-pituitary-adrenal axis of rats].
Fa yi xue za zhi, , Volume: 26, Issue:4 | 2010 |
Inhibition by miltirone of up-regulation of GABAA receptor alpha4 subunit mRNA by ethanol withdrawal in hippocampal neurons.
European journal of pharmacology, , Jun-28, Volume: 494, Issue:2-3 | 2004 |
Chronic aristolochic acid toxicity in rabbits: a model of Chinese herbs nephropathy?
Kidney international, , Volume: 59, Issue:6 | 2001 |
Quantitative analysis of aristolochic acids, toxic compounds, contained in some medicinal plants.
Journal of ethnopharmacology, , Volume: 64, Issue:2 | 1999 |
Miltirone, a central benzodiazepine receptor partial agonist from a Chinese medicinal herb Salvia miltiorrhiza.
Neuroscience letters, , Jun-24, Volume: 127, Issue:2 | 1991 |
Pharmacokinetics (86)
| Article | Year |
|---|
Pharmacokinetics, distribution and efficacy of triptolide PLGA microspheres after intra-articular injection in a rat rheumatoid arthritis model.
Xenobiotica; the fate of foreign compounds in biological systems, , Volume: 51, Issue:6 | 2021 |
Pharmacokinetic, bioavailability, and metabolism studies of lusianthridin, a dihydrophenanthrene compound, in rats by liquid chromatography/electrospray ionization tandem mass spectrometry.
Journal of pharmaceutical and biomedical analysis, , Feb-20, Volume: 195 | 2021 |
Dihydrotanshinone I Increase Amyloid-β Clearance and Decrease Tau Phosphorylation via Enhancing Autophagy.
Pharmacology, , Volume: 105, Issue:5-6 | 2020 |
Comparative pharmacokinetics and tissue distribution of cryptotanshinone, tanshinone IIA, dihydrotanshinone I, and tanshinone I after oral administration of pure tanshinones and liposoluble extract of Salvia miltiorrhiza to rats.
Biopharmaceutics & drug disposition, , Volume: 41, Issue:1-2 | 2020 |
Sodium tanshinone IIA sulfonate: A review of pharmacological activity and pharmacokinetics.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 118 | 2019 |
A network pharmacology integrated pharmacokinetics strategy for uncovering pharmacological mechanism of compounds absorbed into the blood of Dan-Lou tablet on coronary heart disease.
Journal of ethnopharmacology, , Oct-05, Volume: 242 | 2019 |
Dihydromyricetin affect the pharmacokinetics of triptolide in rats.
Xenobiotica; the fate of foreign compounds in biological systems, , Volume: 50, Issue:3 | 2020 |
Lower clearance of sodium tanshinone IIA sulfonate in coronary heart disease patients and the effect of total bilirubin: a population pharmacokinetics analysis.
Chinese journal of natural medicines, , Volume: 17, Issue:3 | 2019 |
Transdermal drug delivery of triptolide-loaded nanostructured lipid carriers: Preparation, pharmacokinetic, and evaluation for rheumatoid arthritis.
International journal of pharmaceutics, , Jan-10, Volume: 554 | 2019 |
Preclinical Pharmacokinetics of Triptolide: A Potential Antitumor Drug.
Current drug metabolism, , Volume: 20, Issue:2 | 2019 |
Effects of Danshen capsules on the pharmacokinetics and pharmacodynamics of clopidogrel in healthy volunteers.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, , Volume: 119 | 2018 |
CYP3A4 inducer and inhibitor strongly affect the pharmacokinetics of triptolide and its derivative in rats.
Acta pharmacologica Sinica, , Volume: 39, Issue:8 | 2018 |
Development of triptolide-nanoemulsion gels for percutaneous administration: physicochemical, transport, pharmacokinetic and pharmacodynamic characteristics.
Journal of nanobiotechnology, , Dec-04, Volume: 15, Issue:1 | 2017 |
Population Pharmacokinetics of Fosdagrocorat (PF-04171327), a Dissociated Glucocorticoid Receptor Agonist, in Patients With Rheumatoid Arthritis.
Clinical and translational science, , Volume: 11, Issue:1 | 2018 |
Association of polycyclic aromatic hydrocarbons exposure with atherosclerotic cardiovascular disease risk: A role of mean platelet volume or club cell secretory protein.
Environmental pollution (Barking, Essex : 1987), , Volume: 233 | 2018 |
Dissociated Agonist of Glucocorticoid Receptor or Prednisone for Active Rheumatoid Arthritis: Effects on P1NP and Osteocalcin Pharmacodynamics.
CPT: pharmacometrics & systems pharmacology, , Volume: 6, Issue:7 | 2017 |
Triptolide Promotes the Clearance of α-Synuclein by Enhancing Autophagy in Neuronal Cells.
Molecular neurobiology, , Volume: 54, Issue:3 | 2017 |
Determination of Sodium Tanshinone IIA Sulfonate in human plasma by LC-MS/MS and its application to a clinical pharmacokinetic study.
Journal of pharmaceutical and biomedical analysis, , Mar-20, Volume: 121 | 2016 |
In situ investigation into surfactant effects on the clearance of polycyclic aromatic hydrocarbons adsorbed onto soybean leaf surfaces.
Environmental pollution (Barking, Essex : 1987), , Volume: 210 | 2016 |
Assessment of pharmacokinetic compatibility of short acting CDRI candidate trioxane derivative, 99-411, with long acting prescription antimalarials, lumefantrine and piperaquine.
Scientific reports, , Nov-25, Volume: 5 | 2015 |
Simultaneous determination of tanshinones and polyphenolics in rat plasma by UPLC-MS/MS and its application to the pharmacokinetic interaction between them.
Drug testing and analysis, , Volume: 8, Issue:7 | 2016 |
Pharmacokinetics and pharmacodynamics of orally administered acetylenic tricyclic bis(cyanoenone), a highly potent Nrf2 activator with a reversible covalent mode of action.
Biochemical and biophysical research communications, , Sep-25, Volume: 465, Issue:3 | 2015 |
Influence of Verapamil on Pharmacokinetics of Triptolide in Rats.
European journal of drug metabolism and pharmacokinetics, , Volume: 41, Issue:4 | 2016 |
Pharmacokinetics and tissue distribution study in mice of triptolide-loaded lipid emulsion and accumulation effect on pancreas.
Drug delivery, , Volume: 23, Issue:4 | 2016 |
Triptolide: progress on research in pharmacodynamics and toxicology.
Journal of ethnopharmacology, , Aug-08, Volume: 155, Issue:1 | 2014 |
Nanostructured lipid carriers as a novel oral delivery system for triptolide: induced changes in pharmacokinetics profile associated with reduced toxicity in male rats.
International journal of nanomedicine, , Volume: 9 | 2014 |
Effects of triptolide on the pharmacokinetics of cyclophosphamide in rats: a possible role of cytochrome P3A4 inhibition.
Chinese journal of integrative medicine, , Volume: 20, Issue:7 | 2014 |
Simultaneous determination of triptolide and its prodrug MC002 in dog blood by LC-MS/MS and its application in pharmacokinetic studies.
Journal of ethnopharmacology, , Oct-28, Volume: 150, Issue:1 | 2013 |
A rapid UFLC-MS/MS method for simultaneous determination of formononetin, cryptotanshinone, tanshinone IIA and emodin in rat plasma and its application to a pharmacokinetic study of Bu Shen Huo Xue formula.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, , Aug-01, Volume: 932 | 2013 |
Population pharmacokinetics of halofantrine in healthy volunteers and patients with symptomatic falciparum malaria.
The Journal of pharmacy and pharmacology, , Volume: 64, Issue:11 | 2012 |
Prediction of the pharmacokinetic parameters of triptolide in rats based on endogenous molecules in pre-dose baseline serum.
PloS one, , Volume: 7, Issue:8 | 2012 |
Intravenous dosing conditions may affect systemic clearance for highly lipophilic drugs: implications for lymphatic transport and absolute bioavailability studies.
Journal of pharmaceutical sciences, , Volume: 101, Issue:9 | 2012 |
[Pharmacokinetics of triptolide in Triptergium wilfordii microemulsion gel].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, , Volume: 36, Issue:2 | 2011 |
[Effects of combination of Salvia miltiorrhiza and Panax notoginseng on the pharmacokinetics of their major bioactive components in Beagle dog].
Yao xue xue bao = Acta pharmaceutica Sinica, , Volume: 45, Issue:11 | 2010 |
Derivatization of (5R)-hydroxytriptolide from benzylamine to enhance mass spectrometric detection: application to a Phase I pharmacokinetic study in humans.
Analytica chimica acta, , Mar-09, Volume: 689, Issue:1 | 2011 |
Simultaneous determination of danshensu, rosmarinic acid, cryptotanshinone, tanshinone IIA, tanshinone I and dihydrotanshinone I by liquid chromatographic-mass spectrometry and the application to pharmacokinetics in rats.
Journal of pharmaceutical and biomedical analysis, , Nov-02, Volume: 53, Issue:3 | 2010 |
Effect of fluconazole on the pharmacokinetics of halofantrine in healthy volunteers.
Journal of clinical pharmacy and therapeutics, , Volume: 34, Issue:6 | 2009 |
Pharmacokinetic interaction studies of tanshinones with tolbutamide, a model CYP2C11 probe substrate, using liver microsomes, primary hepatocytes and in vivo in the rat.
Phytomedicine : international journal of phytotherapy and phytopharmacology, , Volume: 17, Issue:3-4 | 2010 |
Determination of lumefantrine in rat plasma by liquid-liquid extraction using LC-MS/MS with electrospray ionization: assay development, validation and application to a pharmacokinetic study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, , Apr-15, Volume: 877, Issue:11-12 | 2009 |
Lactadherin and clearance of platelet-derived microvesicles.
Blood, , Feb-05, Volume: 113, Issue:6 | 2009 |
Determination of tanshinone I in rat plasma by high-performance liquid chromatography and its application to pharmacokinetic studies.
Journal of chromatographic science, , Volume: 46, Issue:8 | 2008 |
Pharmacokinetic interaction between tanshinones and polyphenolic extracts of salvia miltinorrhiza BUNGE after intravenous administration in rats.
Biological & pharmaceutical bulletin, , Volume: 31, Issue:8 | 2008 |
[Comparative research on pharmacodynamics of Danshen co-microemulsion on hemorheology in rats with hyperlipidemia].
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, , Volume: 31, Issue:4 | 2008 |
Plasma and urinary tanshinol from Salvia miltiorrhiza (Danshen) can be used as pharmacokinetic markers for cardiotonic pills, a cardiovascular herbal medicine.
Drug metabolism and disposition: the biological fate of chemicals, , Volume: 36, Issue:8 | 2008 |
Pharmacokinetic characterization of hydroxylpropyl-beta-cyclodextrin-included complex of cryptotanshinone, an investigational cardiovascular drug purified from Danshen (Salvia miltiorrhiza).
Xenobiotica; the fate of foreign compounds in biological systems, , Volume: 38, Issue:4 | 2008 |
The prediction of the hepatic clearance of tanshinone IIA in rat liver subcellular fractions: accuracy improvement.
Current drug metabolism, , Volume: 9, Issue:1 | 2008 |
Simultaneous determination of tanshinone I, dihydrotanshinone I, tanshinone IIA and cryptotanshinone in rat plasma by liquid chromatography-tandem mass spectrometry: application to a pharmacokinetic study of a standardized fraction of Salvia miltiorrhiza,
Biomedical chromatography : BMC, , Volume: 22, Issue:5 | 2008 |
Preclinical factors affecting the pharmacokinetic behaviour of tanshinone IIA, an investigational new drug isolated from Salvia miltiorrhiza for the treatment of ischaemic heart diseases.
Xenobiotica; the fate of foreign compounds in biological systems, , Volume: 38, Issue:2 | 2008 |
Effect of kolanut on the pharmacokinetics of the antimalarial drug halofantrine.
European journal of clinical pharmacology, , Volume: 64, Issue:1 | 2008 |
Effects of the coexisting diterpenoid tanshinones on the pharmacokinetics of cryptotanshinone and tanshinone IIA in rat.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, , Volume: 32, Issue:4-5 | 2007 |
Simultaneous determination and pharmacokinetic study of water-soluble and lipid-soluble components of danshen in rat plasma using HPLC-UV method.
Biomedical chromatography : BMC, , Volume: 21, Issue:11 | 2007 |
Simultaneous determination of danshensu, ferulic acid, cryptotanshinone and tanshinone IIA in rabbit plasma by HPLC and their pharmacokinetic application in danxiongfang.
Journal of pharmaceutical and biomedical analysis, , Sep-03, Volume: 44, Issue:5 | 2007 |
[Pharmacokinetic interactions between the main components in the extracts of Salvia miltiorrhiza Bge. in rat].
Yao xue xue bao = Acta pharmaceutica Sinica, , Volume: 42, Issue:3 | 2007 |
[Pharmacokinetics of triptolide in Beagle dogs].
Yao xue xue bao = Acta pharmaceutica Sinica, , Volume: 42, Issue:1 | 2007 |
Ion-pair reversed-phase HPLC method for determination of sodium tanshinone IIA sulfonate in biological samples and its pharmacokinetics and biodistribution in mice.
Chemical & pharmaceutical bulletin, , Volume: 55, Issue:5 | 2007 |
Pharmacokinetic study of triptolide, a constituent of immunosuppressive chinese herb medicine, in rats.
Biological & pharmaceutical bulletin, , Volume: 30, Issue:4 | 2007 |
Pharmacokinetics, absorption and tissue distribution of tanshinone IIA solid dispersion.
Planta medica, , Volume: 72, Issue:14 | 2006 |
Liquid chromatographic/mass spectrometry assay of triptolide in dog plasma and its application to pharmacokinetic study.
Journal of pharmaceutical and biomedical analysis, , May-03, Volume: 41, Issue:2 | 2006 |
Danshen: an overview of its chemistry, pharmacology, pharmacokinetics, and clinical use.
Journal of clinical pharmacology, , Volume: 45, Issue:12 | 2005 |
Preparation and pharmacokinetic evaluation of Tashinone IIA solid lipid nanoparticles.
Drug development and industrial pharmacy, , Volume: 31, Issue:6 | 2005 |
Effects of tetracycline on the pharmacokinetics of halofantrine in healthy volunteers.
British journal of clinical pharmacology, , Volume: 58, Issue:1 | 2004 |
Efficacy and pharmacokinetics of intravenous nanocapsule formulations of halofantrine in Plasmodium berghei-infected mice.
Antimicrobial agents and chemotherapy, , Volume: 48, Issue:4 | 2004 |
Biodegradation kinetics of volatile hydrophobic organic compounds in cultures with variable fractional volumes.
Biotechnology and bioengineering, , Mar-20, Volume: 85, Issue:6 | 2004 |
Pharmacokinetics, efficacy and toxicity of parenteral halofantrine in uncomplicated malaria.
British journal of clinical pharmacology, , Volume: 36, Issue:6 | 1993 |
[Determination of tanshinone IIA in rat plasma and the pharmacokinetics by RP-HPLC method].
Yao xue xue bao = Acta pharmaceutica Sinica, , Volume: 38, Issue:5 | 2003 |
Does stereoselective lymphatic absorption contribute to the enantioselective pharmacokinetics of halofantrine In Vivo?
Biopharmaceutics & drug disposition, , Volume: 24, Issue:4 | 2003 |
Pharmacokinetic and pharmacodynamic interaction between grapefruit juice and halofantrine.
Clinical pharmacology and therapeutics, , Volume: 72, Issue:5 | 2002 |
The influence of lipids on stereoselective pharmacokinetics of halofantrine: Important implications in food-effect studies involving drugs that bind to lipoproteins.
Journal of pharmaceutical sciences, , Volume: 91, Issue:8 | 2002 |
Stereoselective pharmacokinetics of desbutylhalofantrine, a metabolite of halofantrine, in the rat after administration of the racemic metabolite or parent drug.
Biopharmaceutics & drug disposition, , Volume: 21, Issue:9 | 2000 |
Pharmacokinetics of halofantrine in the rat: stereoselectivity and interspecies comparisons.
Biopharmaceutics & drug disposition, , Volume: 20, Issue:3 | 1999 |
Altered pharmacokinetics of halofantrine by an antacid, magnesium carbonate.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, , Volume: 46, Issue:3 | 1998 |
Association of halofantrine with postprandially derived plasma lipoproteins decreases its clearance relative to administration in the fasted state.
Journal of pharmaceutical sciences, , Volume: 87, Issue:8 | 1998 |
Pharmacology and pharmacokinetics of new antimalarials.
Medecine tropicale : revue du Corps de sante colonial, , Volume: 55, Issue:4 Suppl | 1995 |
Clinical efficacy and pharmacokinetics of micronized halofantrine for the treatment of acute uncomplicated falciparum malaria in nonimmune patients.
The American journal of tropical medicine and hygiene, , Volume: 51, Issue:2 | 1994 |
Clinical pharmacokinetics in the treatment of tropical diseases. Some applications and limitations.
Clinical pharmacokinetics, , Volume: 27, Issue:2 | 1994 |
Clinical pharmacokinetics of halofantrine.
Clinical pharmacokinetics, , Volume: 27, Issue:2 | 1994 |
Pharmacokinetics of an extended-dose halofantrine regimen in patients with malaria and in healthy volunteers.
Clinical pharmacology and therapeutics, , Volume: 57, Issue:5 | 1995 |
Effect of fasting, induction, sex and age on clearance of benz(a)anthracene and chrysene by isolated perfused rat liver.
Toxicology letters, , Volume: 19, Issue:1-2 | |
Numerical taxonomy of phenanthrene-degrading bacteria isolated from the Chesapeake Bay.
Applied and environmental microbiology, , Volume: 48, Issue:5 | 1984 |
Clinical pharmacokinetics of antimalarial drugs.
Clinical pharmacokinetics, , Volume: 10, Issue:3 | |
[Pharmacokinetics of antimalarials: quinine and mefloquine, halofantrine, qinghaosu, amino-4-quinolines].
Medecine tropicale : revue du Corps de sante colonial, , Volume: 46, Issue:4 | |
In vitro pharmacodynamic assay for cancer drug development: application to crisnatol, a new DNA intercalator.
Cancer research, , Dec-01, Volume: 49, Issue:23 | 1989 |
Pharmacokinetics of halofantrine in man: effects of food and dose size.
British journal of clinical pharmacology, , Volume: 28, Issue:1 | 1989 |
Pharmacokinetics of halofantrine in Thai patients with acute uncomplicated falciparum malaria.
British journal of clinical pharmacology, , Volume: 31, Issue:4 | 1991 |
Pharmacokinetics of halofantrine and n-desbutylhalofantrine in patients with falciparum malaria following a multiple dose regimen of halofantrine.
European journal of clinical pharmacology, , Volume: 41, Issue:2 | 1991 |
Halofantrine. A review of its antimalarial activity, pharmacokinetic properties and therapeutic potential.
Drugs, , Volume: 43, Issue:2 | 1992 |
Bioavailability (278)
| Article | Year |
|---|
Pharmacological activity and clinical progress of Triptolide and its derivatives LLDT-8, PG490-88Na, and Minnelide: a narrative review.
European review for medical and pharmacological sciences, , Volume: 27, Issue:21 | 2023 |
Microplastics reduced bioavailability and altered toxicity of phenanthrene to maize (Zea mays L.) through modulating rhizosphere microbial community and maize growth.
Chemosphere, , Volume: 345 | 2023 |
The role of microplastics in the process of laccase-assisted phytoremediation of phenanthrene-contaminated soil.
The Science of the total environment, , Dec-20, Volume: 905 | 2023 |
Adsorption of Phenanthrene on Multi-Walled Carbon Nanotubes in the Presence of Nonionic Surfactants.
International journal of environmental research and public health, , 02-18, Volume: 20, Issue:4 | 2023 |
Tandemly duplicated CYP82Ds catalyze 14-hydroxylation in triptolide biosynthesis and precursor production in Saccharomyces cerevisiae.
Nature communications, , 02-16, Volume: 14, Issue:1 | 2023 |
Differences in structure and composition of soil humic substances and their binding for polycyclic aromatic hydrocarbons in different climatic zones.
Environmental pollution (Barking, Essex : 1987), , Apr-01, Volume: 322 | 2023 |
Metabolic fates and response strategies of microorganisms to aromatic compounds with different structures.
Bioresource technology, , Volume: 366 | 2022 |
Evaluation of biostimulation, bioaugmentation, and organic amendments application on the bioremediation of recalcitrant hydrocarbons of soil.
Chemosphere, , Volume: 307, Issue:Pt 1 | 2022 |
Promotion of the biodegradation of phenanthrene adsorbed on microplastics by the functional bacterial consortium QY1 in the presence of humic acid: Bioavailability and toxicity evaluation.
Environmental pollution (Barking, Essex : 1987), , Aug-15, Volume: 307 | 2022 |
Interfacial biodegradation of phenanthrene in bacteria-carboxymethyl cellulose-stabilized Pickering emulsions.
Applied microbiology and biotechnology, , Volume: 106, Issue:9-10 | 2022 |
Mechanochemical preparation of triptolide-loaded self-micelle solid dispersion with enhanced oral bioavailability and improved
Drug delivery, , Volume: 29, Issue:1 | 2022 |
Ball-milled biochar can act as a preferable biocompatibility material to enhance phenanthrene degradation by stimulating bacterial metabolism.
Bioresource technology, , Volume: 350 | 2022 |
Inhalable cryptotanshinone spray-dried swellable microparticles for pulmonary fibrosis therapy by regulating TGF-β1/Smad3, STAT3 and SIRT3 pathways.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, , Volume: 172 | 2022 |
Folate-modified triptolide liposomes target activated macrophages for safe rheumatoid arthritis therapy.
Biomaterials science, , Jan-18, Volume: 10, Issue:2 | 2022 |
[Preparation of triptolide-loaded dissolving microneedles and its transdermal penetration].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, , Volume: 46, Issue:20 | 2021 |
Self-assembled fungus-biochar composite pellets (FBPs) for enhanced co-sorption-biodegradation towards phenanthrene.
Chemosphere, , Volume: 286, Issue:Pt 3 | 2022 |
Rhizosphere interactions between PAH-degrading bacteria and Pteris vittata L. on arsenic and phenanthrene dynamics and transformation.
Chemosphere, , Volume: 285 | 2021 |
Sorption mechanism of naphthalene by diesel soot: Insight from displacement with phenanthrene/p-nitrophenol.
Journal of environmental sciences (China), , Volume: 106 | 2021 |
Long-term exposure to environmental levels of phenanthrene disrupts spermatogenesis in male mice.
Environmental pollution (Barking, Essex : 1987), , Sep-15, Volume: 285 | 2021 |
Expression profile of a novel glutathione S-transferase gene in the marine polychaete Perinereis aibuhitensis in short-term responses to phenanthrene, fluoranthene, and benzo[α]pyrene.
Marine pollution bulletin, , Volume: 169 | 2021 |
Bioaugmentation treatment of polycyclic aromatic hydrocarbon-polluted soil in a slurry bioreactor with a bacterial consortium and hydroxypropyl-β-cyclodextrin.
Environmental technology, , Volume: 43, Issue:21 | 2022 |
γ-Cyclodextrin metal-organic framework as a carrier to deliver triptolide for the treatment of hepatocellular carcinoma.
Drug delivery and translational research, , Volume: 12, Issue:5 | 2022 |
Triptolide delivery: Nanotechnology-based carrier systems to enhance efficacy and limit toxicity.
Pharmacological research, , Volume: 165 | 2021 |
Pharmacokinetic, bioavailability, and metabolism studies of lusianthridin, a dihydrophenanthrene compound, in rats by liquid chromatography/electrospray ionization tandem mass spectrometry.
Journal of pharmaceutical and biomedical analysis, , Feb-20, Volume: 195 | 2021 |
Responses of phenanthrene degradation to the changes in bioavailability and microbial community structure in soils amended with biochars pyrolyzed at low and high temperatures.
Journal of hazardous materials, , 05-15, Volume: 410 | 2021 |
Non-targeted metabolomics reveal the impact of phenanthrene stress on root exudates of ten urban greening tree species.
Environmental research, , Volume: 196 | 2021 |
Microbial vanadate reduction coupled to co-metabolic phenanthrene biodegradation in groundwater.
Water research, , Nov-01, Volume: 186 | 2020 |
Therapeutic applications and delivery systems for triptolide.
Drug delivery and translational research, , Volume: 10, Issue:6 | 2020 |
Mechanism of the biodemulsifier-enhanced biodegradation of phenanthrene by Achromobacter sp. LH-1.
Colloids and surfaces. B, Biointerfaces, , Volume: 195 | 2020 |
Competitive Adsorption of Polycyclic Aromatic Hydrocarbons to Carbon Nanotubes and the Impact on Bioavailability to Fathead Minnow (Pimephales promelas).
Environmental toxicology and chemistry, , Volume: 39, Issue:9 | 2020 |
Functional oral nanoparticles for delivering silibinin and cryptotanshinone against breast cancer lung metastasis.
Journal of nanobiotechnology, , May-30, Volume: 18, Issue:1 | 2020 |
Phytoremediation effect of Medicago sativa colonized by Piriformospora indica in the phenanthrene and cadmium co-contaminated soil.
BMC biotechnology, , 04-28, Volume: 20, Issue:1 | 2020 |
Therapeutic targets of thunder god vine (Tripterygium wilfordii hook) in rheumatoid arthritis (Review).
Molecular medicine reports, , Volume: 21, Issue:6 | 2020 |
Different bioavailability of phenanthrene to two bacterial species and effects of trehalose lipids on the bioavailability.
Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering, , Volume: 55, Issue:3 | 2020 |
[Research progress on triptolide functionalized nanoparticulate drug delivery systems for tumor treatment].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, , Volume: 44, Issue:21 | 2019 |
Non-bioavailability of extracellular 1-hydroxy-2-naphthoic acid restricts the mineralization of phenanthrene by Rhodococcus sp. WB9.
The Science of the total environment, , Feb-20, Volume: 704 | 2020 |
Low level of polystyrene microplastics decreases early developmental toxicity of phenanthrene on marine medaka (Oryzias melastigma).
Journal of hazardous materials, , 03-05, Volume: 385 | 2020 |
Design, Synthesis, and in Vitro Biological Evaluation of 14-Hydroxytylophorine-dichloroacetate Co-drugs as Antiproliferative Agents.
Chemical & pharmaceutical bulletin, , Nov-01, Volume: 67, Issue:11 | 2019 |
Partitioning of chemical contaminants to microplastics: Sorption mechanisms, environmental distribution and effects on toxicity and bioaccumulation.
Environmental pollution (Barking, Essex : 1987), , Volume: 252, Issue:Pt B | 2019 |
Triptolide: Medicinal chemistry, chemical biology and clinical progress.
European journal of medicinal chemistry, , Aug-15, Volume: 176 | 2019 |
Cubic and hexagonal liquid crystals as drug carriers for the transdermal delivery of triptolide.
Drug delivery, , Volume: 26, Issue:1 | 2019 |
Triptolide and Its Derivatives as Cancer Therapies.
Trends in pharmacological sciences, , Volume: 40, Issue:5 | 2019 |
Natural and assisted dissipation of polycyclic aromatic hydrocarbons in a long-term co-contaminated soil with creosote and potentially toxic elements.
The Science of the total environment, , Apr-10, Volume: 660 | 2019 |
Biodegradation of phenanthrene by biodemulsifier-producing strain Achromobacter sp. LH-1 and the study on its metabolisms and fermentation kinetics.
Ecotoxicology and environmental safety, , Nov-15, Volume: 163 | 2018 |
[Sorption of Phenanthrene to Soybean and Wheat Roots and the Bioavailability of Sorbed Phenanthrene].
Huan jing ke xue= Huanjing kexue, , Jun-08, Volume: 38, Issue:6 | 2017 |
Rhamnolipid influences biosorption and biodegradation of phenanthrene by phenanthrene-degrading strain Pseudomonas sp. Ph6.
Environmental pollution (Barking, Essex : 1987), , Volume: 240 | 2018 |
Reduced bioavailability and plant uptake of polycyclic aromatic hydrocarbons from soil slurry amended with biochars pyrolyzed under various temperatures.
Environmental science and pollution research international, , Volume: 25, Issue:17 | 2018 |
Investigations of microbial degradation of polycyclic aromatic hydrocarbons based on
Environmental science and pollution research international, , Volume: 25, Issue:7 | 2018 |
Transepithelial transfer of phenanthrene, but not of benzo[a]pyrene, is inhibited by fatty acids in the proximal intestine of rainbow trout (Oncorhynchus mykiss).
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, , Volume: 204 | 2018 |
Interactions between Pteris vittata L. genotypes and a polycyclic aromatic hydrocarbon (PAH)-degrading bacterium (Alcaligenes sp.) in arsenic uptake and PAH-dissipation.
Environmental pollution (Barking, Essex : 1987), , Volume: 230 | 2017 |
Solution or suspension - Does it matter for lipid based systems? In vivo studies of chase dosing lipid vehicles with aqueous suspensions of a poorly soluble drug.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, , Volume: 117 | 2017 |
Response of low-molecular-weight organic acids in mangrove root exudates to exposure of polycyclic aromatic hydrocarbons.
Environmental science and pollution research international, , Volume: 24, Issue:13 | 2017 |
Assessment of microplastic-sorbed contaminant bioavailability through analysis of biomarker gene expression in larval zebrafish.
Marine pollution bulletin, , Mar-15, Volume: 116, Issue:1-2 | 2017 |
Enhancement of the bioavailability of a novel anticancer compound (acetyltanshinone IIA) by encapsulation within mPEG-PLGA nanoparticles: a study of formulation optimization, toxicity, and pharmacokinetics.
Oncotarget, , Feb-14, Volume: 8, Issue:7 | 2017 |
Effects of dissolved organic matter derived from forest leaf litter on biodegradation of phenanthrene in aqueous phase.
Journal of hazardous materials, , Feb-15, Volume: 324, Issue:Pt B | 2017 |
Phenanthrene Bioavailability and Toxicity to Daphnia magna in the Presence of Carbon Nanotubes with Different Physicochemical Properties.
Environmental science & technology, , 11-15, Volume: 50, Issue:22 | 2016 |
Specific adsorption of cadmium on surface-engineered biocompatible organoclay under metal-phenanthrene mixed-contamination.
Water research, , Nov-01, Volume: 104 | 2016 |
Influence of temperature on phenanthrene toxicity towards nitrifying bacteria in three soils with different properties.
Environmental pollution (Barking, Essex : 1987), , Volume: 216 | 2016 |
Mycoremediation of manganese and phenanthrene by Pleurotus eryngii mycelium enhanced by Tween 80 and saponin.
Applied microbiology and biotechnology, , Volume: 100, Issue:16 | 2016 |
[Aging Law of PAHs in Contaminated Soil and Their Enrichment in Earthworms Characterized by Chemical Extraction Techniques].
Huan jing ke xue= Huanjing kexue, , Volume: 36, Issue:12 | 2015 |
Carbon Nanotube Properties Influence Adsorption of Phenanthrene and Subsequent Bioavailability and Toxicity to Pseudokirchneriella subcapitata.
Environmental science & technology, , Mar-01, Volume: 50, Issue:5 | 2016 |
Influences of humic acid on the bioavailability of phenanthrene and alkyl phenanthrenes to early life stages of marine medaka (Oryzias melastigma).
Environmental pollution (Barking, Essex : 1987), , Volume: 210 | 2016 |
Electrokinetic-Enhanced Remediation of Phenanthrene-Contaminated Soil Combined with Sphingomonas sp. GY2B and Biosurfactant.
Applied biochemistry and biotechnology, , Volume: 178, Issue:7 | 2016 |
Effects of root exudates on the leachability, distribution, and bioavailability of phenanthrene and pyrene from mangrove sediments.
Environmental science and pollution research international, , Volume: 23, Issue:6 | 2016 |
The Effect of Digestion and Drug Load on Halofantrine Absorption from Self-nanoemulsifying Drug Delivery System (SNEDDS).
The AAPS journal, , Volume: 18, Issue:1 | 2016 |
Extractive biodegradation and bioavailability assessment of phenanthrene in the cloud point system by Sphingomonas polyaromaticivorans.
Applied microbiology and biotechnology, , Volume: 100, Issue:1 | 2016 |
Simultaneous determination of tanshinones and polyphenolics in rat plasma by UPLC-MS/MS and its application to the pharmacokinetic interaction between them.
Drug testing and analysis, , Volume: 8, Issue:7 | 2016 |
Effects of cowpea (Vigna unguiculata) root mucilage on microbial community response and capacity for phenanthrene remediation.
Journal of environmental sciences (China), , Jul-01, Volume: 33 | 2015 |
Extracellular polymeric substances govern the development of biofilm and mass transfer of polycyclic aromatic hydrocarbons for improved biodegradation.
Bioresource technology, , Volume: 193 | 2015 |
Heavy metal-immobilizing organoclay facilitates polycyclic aromatic hydrocarbon biodegradation in mixed-contaminated soil.
Journal of hazardous materials, , Nov-15, Volume: 298 | 2015 |
Absorption and Metabolism Characteristics of Triptolide as Determined by a Sensitive and Reliable LC-MS/MS Method.
Molecules (Basel, Switzerland), , May-18, Volume: 20, Issue:5 | 2015 |
Fluorene and Phenanthrene Uptake and Accumulation by Wheat, Alfalfa and Sunflower from the Contaminated Soil.
International journal of phytoremediation, , Volume: 17, Issue:12 | 2015 |
Simultaneous quantification of proposed anti-malarial combination comprising of lumefantrine and CDRI 97-78 in rat plasma using the HPLC-ESI-MS/MS method: application to drug interaction study.
Malaria journal, , Apr-22, Volume: 14 | 2015 |
The influence of multiwalled carbon nanotubes on polycyclic aromatic hydrocarbon (PAH) bioavailability and toxicity to soil microbial communities in alfalfa rhizosphere.
Ecotoxicology and environmental safety, , Volume: 116 | 2015 |
Comparing the genotoxicity of a potentially carcinogenic and a noncarcinogenic PAH, singly, and in binary combination, on peripheral blood cells of the European sea bass.
Environmental toxicology, , Volume: 31, Issue:11 | 2016 |
Characterising the exchangeability of phenanthrene associated with naturally occurring soil colloids using an isotopic dilution technique.
Environmental pollution (Barking, Essex : 1987), , Volume: 199 | 2015 |
Cysteine-β-cyclodextrin enhanced phytoremediation of soil co-contaminated with phenanthrene and lead.
Environmental science and pollution research international, , Volume: 22, Issue:13 | 2015 |
Fullerene-associated phenanthrene contributes to bioaccumulation but is not toxic to fish.
Environmental toxicology and chemistry, , Volume: 34, Issue:5 | 2015 |
In silico understanding of the cyclodextrin-phenanthrene hybrid assemblies in both aqueous medium and bacterial membranes.
Journal of hazardous materials, , Mar-21, Volume: 285 | 2015 |
Dissipation of phenanthrene and pyrene at the aerobic-anaerobic soil interface: differentiation induced by the rhizosphere of PAH-tolerant and PAH-sensitive rice (Oryza sativa L.) cultivars.
Environmental science and pollution research international, , Volume: 22, Issue:5 | 2015 |
The impact of biochar on the bioaccessibility of (14)C-phenanthrene in aged soil.
Environmental science. Processes & impacts, , Volume: 16, Issue:11 | 2014 |
Role of desorption kinetics in the rhamnolipid-enhanced biodegradation of polycyclic aromatic hydrocarbons.
Environmental science & technology, , Sep-16, Volume: 48, Issue:18 | 2014 |
Enhancing plant-microbe associated bioremediation of phenanthrene and pyrene contaminated soil by SDBS-Tween 80 mixed surfactants.
Journal of environmental sciences (China), , May-01, Volume: 26, Issue:5 | 2014 |
Combined effects of DOM and biosurfactant enhanced biodegradation of polycylic armotic hydrocarbons (PAHs) in soil-water systems.
Environmental science and pollution research international, , Volume: 21, Issue:17 | 2014 |
Hydroxypropyl-β-cyclodextrin extractability and bioavailability of phenanthrene in humin and humic acid fractions from different soils and sediments.
Environmental science and pollution research international, , Volume: 21, Issue:14 | 2014 |
Bioavailability of hydrocarbons to bacterial consortia during Triton X-100 mediated biodegradation in aqueous media.
Acta biochimica Polonica, , Volume: 60, Issue:4 | 2013 |
Potential use of a self-dying reporter bacterium to determine the bioavailability of aged phenanthrene in soil: comparison with physicochemical measures.
Journal of hazardous materials, , Jan-30, Volume: 265 | 2014 |
The variability of standard artificial soils: behaviour, extractability and bioavailability of organic pollutants.
Journal of hazardous materials, , Jan-15, Volume: 264 | 2014 |
Isolation and characterization of a novel phenanthrene (PHE) degrading strain Psuedomonas sp. USTB-RU from petroleum contaminated soil.
Journal of hazardous materials, , Dec-15, Volume: 263 Pt 2 | 2013 |
Utilizing surfactants to control the sorption, desorption, and biodegradation of phenanthrene in soil-water system.
Journal of environmental sciences (China), , Jul-01, Volume: 25, Issue:7 | 2013 |
Polycyclic aromatic hydrocarbon degradation of phytoplankton-associated Arenibacter spp. and description of Arenibacter algicola sp. nov., an aromatic hydrocarbon-degrading bacterium.
Applied and environmental microbiology, , Volume: 80, Issue:2 | 2014 |
Effects of sterile storage, cation saturation and substrate additions on the degradability and extractability of nonylphenol and phenanthrene in soil.
Chemosphere, , Volume: 93, Issue:9 | 2013 |
Identification of soil bacteria able to degrade phenanthrene bound to a hydrophobic sorbent in situ.
Environmental pollution (Barking, Essex : 1987), , Volume: 180 | 2013 |
Partitioning of phenanthrene into surfactant hemi-micelles on the bacterial cell surface and implications for surfactant-enhanced biodegradation.
Water research, , Sep-01, Volume: 47, Issue:13 | 2013 |
Bioaccumulation-depuration kinetics and effects of phenanthrene on Mediterranean mussel (Mytilus galloprovincialis).
Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering, , Volume: 48, Issue:9 | 2013 |
A mouse model to evaluate the impact of species, sex, and lipid load on lymphatic drug transport.
Pharmaceutical research, , Volume: 30, Issue:12 | 2013 |
Reduction in the earthworm metabolomic response after phenanthrene exposure in soils with high soil organic carbon content.
Environmental pollution (Barking, Essex : 1987), , Volume: 175 | 2013 |
Mineralization of phenanthrene sorbed on multiwalled carbon nanotubes.
Environmental toxicology and chemistry, , Volume: 32, Issue:4 | 2013 |
Synthesis and biological evaluation of tylophorine-derived dibenzoquinolines as orally active agents: exploration of the role of tylophorine e ring on biological activity.
Journal of medicinal chemistry, , Dec-13, Volume: 55, Issue:23 | 2012 |
Population pharmacokinetics of halofantrine in healthy volunteers and patients with symptomatic falciparum malaria.
The Journal of pharmacy and pharmacology, , Volume: 64, Issue:11 | 2012 |
Dosage (180)
| Article | Year |
|---|
Microbe combined with Fe
Environmental science and pollution research international, , Volume: 30, Issue:53 | 2023 |
Impact of phenanthrene co-administration on the toxicokinetics of benzo[a]pyrene in humans. UPLC-accelerator mass spectrometry following oral microdosing.
Chemico-biological interactions, , Sep-01, Volume: 382 | 2023 |
Taxonomic and functional responses of soil and root bacterial communities associated with poplar exposed to a contamination gradient of phenanthrene.
FEMS microbiology ecology, , 05-31, Volume: 99, Issue:6 | 2023 |
A comprehensive review on celastrol, triptolide and triptonide: Insights on their pharmacological activity, toxicity, combination therapy, new dosage form and novel drug delivery routes.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 162 | 2023 |
A pH-responsive phosphoprotein washing fluid for the removal of phenanthrene from contaminated peat moss in the cold region.
Chemosphere, , Volume: 313 | 2023 |
Hydrophobic microporous extraction on polyurethane sponges for convenient and sensitive analysis of organic molecules in water.
Rapid communications in mass spectrometry : RCM, , Nov-15, Volume: 36, Issue:21 | 2022 |
Urinary polycyclic aromatic hydrocarbon metabolites were associated with hypertension in US adults: data from NHANES 2009-2016.
Environmental science and pollution research international, , Volume: 29, Issue:53 | 2022 |
Novel CD44-targeting and pH/redox-dual-stimuli-responsive core-shell nanoparticles loading triptolide combats breast cancer growth and lung metastasis.
Journal of nanobiotechnology, , Jun-23, Volume: 19, Issue:1 | 2021 |
Toxicity of two representative petroleum hydrocarbons, toluene and phenanthrene, to five Atlantic coral species.
Marine pollution bulletin, , Volume: 169 | 2021 |
Pharmacokinetics, distribution and efficacy of triptolide PLGA microspheres after intra-articular injection in a rat rheumatoid arthritis model.
Xenobiotica; the fate of foreign compounds in biological systems, , Volume: 51, Issue:6 | 2021 |
A pilot study of golexanolone, a new GABA-A receptor-modulating steroid antagonist, in patients with covert hepatic encephalopathy.
Journal of hepatology, , Volume: 75, Issue:1 | 2021 |
Alkylated phenanthrene distributions in black rockfish (Sebastes schlegelii) and biotransformation into hydroxylated metabolites after intragastric administration.
The Science of the total environment, , Mar-25, Volume: 762 | 2021 |
Measured and predicted acute toxicity of phenanthrene and MC252 crude oil to vertically migrating deep-sea crustaceans.
Environmental science and pollution research international, , Volume: 27, Issue:36 | 2020 |
Circadian clock regulates hepatotoxicity of Tripterygium wilfordii through modulation of metabolism.
The Journal of pharmacy and pharmacology, , Volume: 72, Issue:12 | 2020 |
Therapeutic targets of thunder god vine (Tripterygium wilfordii hook) in rheumatoid arthritis (Review).
Molecular medicine reports, , Volume: 21, Issue:6 | 2020 |
Pharmacological and molecular docking assessment of cryptotanshinone as natural-derived analgesic compound.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 126 | 2020 |
Gut microbiota protects from triptolide-induced hepatotoxicity: Key role of propionate and its downstream signalling events.
Pharmacological research, , Volume: 155 | 2020 |
Sodium tanshinone IIA sulfonate protects against Aβ
International journal of biological macromolecules, , May-15, Volume: 151 | 2020 |
Assessment of schwertmannite, jarosite and goethite as adsorbents for efficient adsorption of phenanthrene in water and the regeneration of spent adsorbents by heterogeneous fenton-like reaction.
Chemosphere, , Volume: 244 | 2020 |
[Effect of triptolide on Th17/Treg cells in spleen].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, , Volume: 44, Issue:15 | 2019 |
Degradation of phenanthrene and fluoranthene in a slurry bioreactor using free and Ca-alginate-immobilized Sphingomonas pseudosanguinis and Pseudomonas stutzeri bacteria.
Journal of environmental management, , Nov-01, Volume: 249 | 2019 |
Effects of phenanthrene on oxidative stress and inflammation in lung and liver of female rats.
Environmental toxicology, , Volume: 35, Issue:1 | 2020 |
Dihydromyricetin affect the pharmacokinetics of triptolide in rats.
Xenobiotica; the fate of foreign compounds in biological systems, , Volume: 50, Issue:3 | 2020 |
Removal of phenanthrene and pyrene from contaminated sandy soil using hydrogen peroxide oxidation catalyzed by basic oxygen furnace slag.
Environmental science and pollution research international, , Volume: 26, Issue:9 | 2019 |
Dual-function of triptriolide in podocytes injury: inhibiting of apoptosis and restoring of survival.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 109 | 2019 |
Identification of hepatotoxic and nephrotoxic potential markers of triptolide in mice with delayed-type hypersensitivity.
Journal of pharmaceutical and biomedical analysis, , Oct-25, Volume: 160 | 2018 |
[Triptolide induces oxidative stress and apoptosis and activates PIK3/Akt signaling pathway in TM4 sertoli cells].
Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences, , Aug-18, Volume: 50, Issue:4 | 2018 |
Preclinical Pharmacokinetics of Triptolide: A Potential Antitumor Drug.
Current drug metabolism, , Volume: 20, Issue:2 | 2019 |
[Preparation and transdermal permeation of triptolide and ferulic acid ethosomes gel
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, , Volume: 43, Issue:6 | 2018 |
[Effects of Triptolide Combined with Homoharringtonine on Proliferation and Apoptosis of KG-1α Cells].
Zhongguo shi yan xue ye xue za zhi, , Volume: 26, Issue:2 | 2018 |
Renal and Hematologic Comparative Effects of Dissociated Agonist of the Glucocorticoid Receptor and Prednisone in Dogs With and Without Food Restriction.
International journal of toxicology, , Volume: 37, Issue:3 | |
In-situ examination of graphene and graphene oxide impact on the depuration of phenanthrene and fluoranthene adsorbed onto spinach (Spinacia oleracea L.) leaf surfaces.
Environmental pollution (Barking, Essex : 1987), , Volume: 237 | 2018 |
EFFECT OF TRIPTOLIDE ON PROLIFERATION AND APOPTOSIS OF ANGIOTENSIN II-INDUCED CARDIAC FIBROBLASTS
African journal of traditional, complementary, and alternative medicines : AJTCAM, , Volume: 14, Issue:1 | 2017 |
Solution or suspension - Does it matter for lipid based systems? In vivo studies of chase dosing lipid vehicles with aqueous suspensions of a poorly soluble drug.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, , Volume: 117 | 2017 |
JTP-117968, a novel selective glucocorticoid receptor modulator, exhibits improved transrepression/transactivation dissociation.
European journal of pharmacology, , May-15, Volume: 803 | 2017 |
Response of phenolic metabolism to cadmium and phenanthrene and its influence on pollutant translocations in the mangrove plant Aegiceras corniculatum (L.) Blanco (Ac).
Ecotoxicology and environmental safety, , Volume: 141 | 2017 |
Analysis of 3D Prints by X-ray Computed Microtomography and Terahertz Pulsed Imaging.
Pharmaceutical research, , Volume: 34, Issue:5 | 2017 |
Protective effects of triptolide on TLR4 mediated autoimmune and inflammatory response induced myocardial fibrosis in diabetic cardiomyopathy.
Journal of ethnopharmacology, , Dec-04, Volume: 193 | 2016 |
Triptolide inhibits cell growth and GRP78 protein expression but induces cell apoptosis in original and radioresistant NPC cells.
Oncotarget, , Aug-02, Volume: 7, Issue:31 | 2016 |
Adsorption and bioaccessibility of phenanthrene on carbon nanotubes in the in vitro gastrointestinal system.
The Science of the total environment, , Oct-01, Volume: 566-567 | 2016 |
Predicting the probability of successful efficacy of a dissociated agonist of the glucocorticoid receptor from dose-response analysis.
Journal of pharmacokinetics and pharmacodynamics, , Volume: 43, Issue:3 | 2016 |
Applying quantitative and semi-quantitative histopathology to address the interaction between sediment-bound polycyclic aromatic hydrocarbons in fish gills.
Ecotoxicology and environmental safety, , Volume: 131 | 2016 |
The Effect of Digestion and Drug Load on Halofantrine Absorption from Self-nanoemulsifying Drug Delivery System (SNEDDS).
The AAPS journal, , Volume: 18, Issue:1 | 2016 |
Pharmacokinetics and pharmacodynamics of orally administered acetylenic tricyclic bis(cyanoenone), a highly potent Nrf2 activator with a reversible covalent mode of action.
Biochemical and biophysical research communications, , Sep-25, Volume: 465, Issue:3 | 2015 |
A high throughput passive dosing format for the Fish Embryo Acute Toxicity test.
Chemosphere, , Volume: 139 | 2015 |
Reproductive and transgenerational toxicities of phenanthrene on female marine medaka (Oryzias melastigma).
Aquatic toxicology (Amsterdam, Netherlands), , Volume: 162 | 2015 |
How does predation affect the bioaccumulation of hydrophobic organic compounds in aquatic organisms?
Environmental science & technology, , Apr-21, Volume: 49, Issue:8 | 2015 |
Enterocarpam-III induces human liver and breast cancer cell apoptosis via mitochondrial and caspase-9 activation.
Asian Pacific journal of cancer prevention : APJCP, , Volume: 16, Issue:5 | 2015 |
Gender Differences in the Toxicokinetics of Triptolide after Single- and Multiple-dose Administration in Rats.
Drug research, , Volume: 65, Issue:11 | 2015 |
Cryptotanshinone, an orally bioactive herbal compound from Danshen, attenuates atherosclerosis in apolipoprotein E-deficient mice: role of lectin-like oxidized LDL receptor-1 (LOX-1).
British journal of pharmacology, , Volume: 172, Issue:23 | 2015 |
Two new anxiolytic phenanthrenes found in the medullae of Juncus effusus.
Natural product communications, , Volume: 9, Issue:8 | 2014 |
Enhancing plant-microbe associated bioremediation of phenanthrene and pyrene contaminated soil by SDBS-Tween 80 mixed surfactants.
Journal of environmental sciences (China), , May-01, Volume: 26, Issue:5 | 2014 |
Simultaneous control of phenanthrene and drought by dual exposure system: the degree of synergistic interactions in springtails was exposure dependent.
Environmental science & technology, , Aug-19, Volume: 48, Issue:16 | 2014 |
[Adsorption of phenanthrene from aqueous solution on cetylpyridinium bromide (CPB) -modified zeolite].
Huan jing ke xue= Huanjing kexue, , Volume: 35, Issue:2 | 2014 |
Oxidative stress and DNA damage responses to phenanthrene exposure in the estuarine guppy Poecilia vivipara.
Marine environmental research, , Volume: 98 | 2014 |
Nanostructured lipid carriers as a novel oral delivery system for triptolide: induced changes in pharmacokinetics profile associated with reduced toxicity in male rats.
International journal of nanomedicine, , Volume: 9 | 2014 |
Efficacy of triptolide for children with moderately severe Henoch-Schönlein purpura nephritis presenting with nephrotic range proteinuria: a prospective and controlled study in China.
BioMed research international, , Volume: 2013 | 2013 |
Accelerated follicle depletion in vitro and in vivo in Sprague-Dawley rats using the combination of 4-vinylcyclohexene diepoxide and triptolide.
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians, , Volume: 44, Issue:4 Suppl | 2013 |
Tanshinone VI inhibits the expression of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1.
International journal of immunopathology and pharmacology, , Volume: 26, Issue:4 | |
Adsorption of phenanthrene on multilayer graphene as affected by surfactant and exfoliation.
Environmental science & technology, , Volume: 48, Issue:1 | 2014 |
Physiological and molecular responses of springtails exposed to phenanthrene and drought.
Environmental pollution (Barking, Essex : 1987), , Volume: 184 | 2014 |
Phenanthrene binding by humic acid-protein complexes as studied by passive dosing technique.
Environmental pollution (Barking, Essex : 1987), , Volume: 184 | 2014 |
A novel passive dosing system for determining the toxicity of phenanthrene to early life stages of zebrafish.
The Science of the total environment, , Oct-01, Volume: 463-464 | 2013 |
Herbal compound triptolide synergistically enhanced antitumor activity of amino-terminal fragment of urokinase.
Molecular cancer, , Jun-08, Volume: 12 | 2013 |
The impact of lymphatic transport on the systemic disposition of lipophilic drugs.
Journal of pharmaceutical sciences, , Volume: 102, Issue:7 | 2013 |
CDA: combinatorial drug discovery using transcriptional response modules.
PloS one, , Volume: 7, Issue:8 | 2012 |
Using resin to generate a non-invasive intestinal bile-depleted rat model was unsuccessful.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, , Sep-29, Volume: 47, Issue:2 | 2012 |
Comparison of toxicokinetic and tissue distribution of triptolide-loaded solid lipid nanoparticles vs free triptolide in rats.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, , Nov-20, Volume: 47, Issue:4 | 2012 |
Intravenous dosing conditions may affect systemic clearance for highly lipophilic drugs: implications for lymphatic transport and absolute bioavailability studies.
Journal of pharmaceutical sciences, , Volume: 101, Issue:9 | 2012 |
Pulmonary surfactant suppressed phenanthrene adsorption on carbon nanotubes through solubilization and competition as examined by passive dosing technique.
Environmental science & technology, , May-15, Volume: 46, Issue:10 | 2012 |
Effects of triptolide on the synaptophysin expression of hippocampal neurons in the AD cellular model.
International immunopharmacology, , Volume: 13, Issue:2 | 2012 |
Influence of bile on the absorption of halofantrine from lipid-based formulations.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, , Volume: 81, Issue:2 | 2012 |
Dynamic passive dosing for studying the biotransformation of hydrophobic organic chemicals: microbial degradation as an example.
Environmental science & technology, , May-01, Volume: 46, Issue:9 | 2012 |
In vitro and in vivo performance of novel supersaturated self-nanoemulsifying drug delivery systems (super-SNEDDS).
Journal of controlled release : official journal of the Controlled Release Society, , May-30, Volume: 160, Issue:1 | 2012 |
Chronic exposure to phenanthrene influences the spermatogenesis of male Sebastiscus marmoratus: U-shaped effects and the reason for them.
Environmental science & technology, , Dec-01, Volume: 45, Issue:23 | 2011 |
In vitro properties of surface-modified solid lipid microspheres containing an antimalarial drug: halofantrine.
Asian Pacific journal of tropical medicine, , Volume: 4, Issue:4 | 2011 |
A high-sensitivity UPLC-MS/MS method for simultaneous determination and confirmation of triptolide in zebrafish embryos.
Biomedical chromatography : BMC, , Volume: 25, Issue:8 | 2011 |
Effect of bile on the oral absorption of halofantrine in polyethylene glycol 400 and polysorbate 80 formulations dosed to bile duct cannulated rats.
The Journal of pharmacy and pharmacology, , Volume: 63, Issue:6 | 2011 |
Metabolism of [D10]phenanthrene to tetraols in smokers for potential lung cancer susceptibility assessment: comparison of oral and inhalation routes of administration.
The Journal of pharmacology and experimental therapeutics, , Volume: 338, Issue:1 | 2011 |
EROD activity in peripheral blood lymphocytes and 1-hydroxypyrene in urine and milk as biomarkers of PAH exposure in dairy ruminants.
Environmental toxicology and chemistry, , Volume: 30, Issue:6 | 2011 |
[Absorption mechanism of tanshinone II A, cryptotanshinone, tanshinone I and tanshinones extract in rat small intestine in vivo].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, , Volume: 35, Issue:21 | 2010 |
A novel excipient, 1-perfluorohexyloctane shows limited utility for the oral delivery of poorly water-soluble drugs.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, , Mar-18, Volume: 42, Issue:4 | 2011 |
Bioaccumulation of 14C60 by the earthworm Eisenia fetida.
Environmental science & technology, , Dec-01, Volume: 44, Issue:23 | 2010 |
Effects of polysorbate 80 on the in-vitro precipitation and oral bioavailability of halofantrine from polyethylene glycol 400 formulations in rats.
The Journal of pharmacy and pharmacology, , Volume: 62, Issue:1 | 2010 |
Sex differences in subacute toxicity and hepatic microsomal metabolism of triptolide in rats.
Toxicology, , Apr-30, Volume: 271, Issue:1-2 | 2010 |
Transfer kinetics to egg yolk and modeling residue recovered in yolk of readily metabolized molecules: polycyclic aromatic hydrocarbons orally administered to laying hens.
Chemosphere, , Volume: 78, Issue:8 | 2010 |
Effects of phenanthrene on hepatic enzymatic activities in tilapia (Oreochromis niloticus female x O. aureus male).
Journal of environmental sciences (China), , Volume: 21, Issue:6 | 2009 |
Lymphatic transport of Methylnortestosterone undecanoate (MU) and the bioavailability of methylnortestosterone are highly sensitive to the mass of coadministered lipid after oral administration of MU.
The Journal of pharmacology and experimental therapeutics, , Volume: 331, Issue:2 | 2009 |
Sodium tanshinone IIA sulfonate increased intestinal hemodynamics without systemic circulatory changes in healthy newborn piglets.
American journal of physiology. Heart and circulatory physiology, , Volume: 297, Issue:4 | 2009 |
Triptolide functions as a potent angiogenesis inhibitor.
International journal of cancer, , Jan-01, Volume: 126, Issue:1 | 2010 |
Double-tagged fluorescent bacterial bioreporter for the study of polycyclic aromatic hydrocarbon diffusion and bioavailability.
Environmental microbiology, , Volume: 11, Issue:9 | 2009 |
Impact of recurring intermediate insulin-induced hypoglycemia on hypothalamic paraventricular corticotropin-releasing hormone, oxytocin, vasopressin and glucokinase gene profiles: role of type II glucocorticoid receptors.
Experimental brain research, , Volume: 195, Issue:4 | 2009 |
[Suppression of murine EAE by triptolide is related to downregulation of INF-gamma and upregulation of IL-10 secretion in splenic lymphocytes].
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, , Volume: 25, Issue:3 | 2009 |
Identification of surrogate measures of diesel exhaust exposure in a controlled chamber study.
Environmental science & technology, , Dec-01, Volume: 42, Issue:23 | 2008 |
The effect of experimental hyperlipidemia on the stereoselective tissue distribution, lipoprotein association and microsomal metabolism of (+/-)-halofantrine.
Journal of pharmaceutical sciences, , Volume: 98, Issue:7 | 2009 |
Multigeneration exposure of the springtail Folsomia candida to phenanthrone: from dose-response relationships to threshold concentrations.
Environmental science & technology, , Sep-15, Volume: 42, Issue:18 | 2008 |
Intestinal lymphatic transport of halofantrine in rats assessed using a chylomicron flow blocking approach: the influence of polysorbate 60 and 80.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, , Oct-02, Volume: 35, Issue:3 | 2008 |
Pharmacokinetic interaction between tanshinones and polyphenolic extracts of salvia miltinorrhiza BUNGE after intravenous administration in rats.
Biological & pharmaceutical bulletin, , Volume: 31, Issue:8 | 2008 |
Effect of oxidant dosage on integrated electrochemical remediation of contaminant mixtures in soils.
Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering, , Jul-01, Volume: 43, Issue:8 | 2008 |
Preclinical factors affecting the pharmacokinetic behaviour of tanshinone IIA, an investigational new drug isolated from Salvia miltiorrhiza for the treatment of ischaemic heart diseases.
Xenobiotica; the fate of foreign compounds in biological systems, , Volume: 38, Issue:2 | 2008 |
Interactions (20)
| Article | Year |
|---|
Microbe combined with Fe
Environmental science and pollution research international, , Volume: 30, Issue:53 | 2023 |
Effects and mechanisms of trifluridine alone or in combination with cryptotanshinone in inhibiting malignant biological behavior of gastric cancer.
Cell cycle (Georgetown, Tex.), , Volume: 22, Issue:12 | 2023 |
Quantitative analysis of polycyclic aromatic hydrocarbons (PAHs) in water by surface-enhanced Raman spectroscopy (SERS) combined with Random Forest.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, , Feb-15, Volume: 287, Issue:Pt 1 | 2023 |
Detoxification strategies of triptolide based on drug combinations and targeted delivery methods.
Toxicology, , 03-15, Volume: 469 | 2022 |
Identification of lusianthridin metabolites in rat liver microsomes by liquid chromatography combined with electrospray ionization time-of-flight mass spectrometry.
Biomedical chromatography : BMC, , Volume: 35, Issue:3 | 2021 |
Study on the molecular interactions of hydroxylated polycyclic aromatic hydrocarbons with catalase using multi-spectral methods combined with molecular docking.
Food chemistry, , Mar-30, Volume: 309 | 2020 |
Comparison of the effect of three different topoisomerase II inhibitors combined with cisplatin in human glioblastoma cells sensitized with double strand break repair inhibitors.
Molecular biology reports, , Volume: 46, Issue:4 | 2019 |
Ghrelin combined with sodium tanshinone IIA sulfonate pretreatment reduces apoptosis and fractalkine expression induced by high-dose glucose in human umbilical vein endothelial cells.
Minerva endocrinologica, , Volume: 45, Issue:1 | 2020 |
[Effects of Triptolide Combined with Homoharringtonine on Proliferation and Apoptosis of KG-1α Cells].
Zhongguo shi yan xue ye xue za zhi, , Volume: 26, Issue:2 | 2018 |
Dihydroisotanshinone I combined with radiation inhibits the migration ability of prostate cancer cells through DNA damage and CCL2 pathway.
BMC pharmacology & toxicology, , 01-31, Volume: 19, Issue:1 | 2018 |
AMD3100 combined with triptolide inhibit proliferation, invasion and metastasis and induce apoptosis of human U2OS osteosarcoma cells.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 86 | 2017 |
Electrokinetic-Enhanced Remediation of Phenanthrene-Contaminated Soil Combined with Sphingomonas sp. GY2B and Biosurfactant.
Applied biochemistry and biotechnology, , Volume: 178, Issue:7 | 2016 |
Treatment of murine cerebral malaria by artemisone in combination with conventional antimalarial drugs: antiplasmodial effects and immune responses.
Antimicrobial agents and chemotherapy, , Volume: 58, Issue:8 | 2014 |
Low-dose triptolide in combination with idarubicin induces apoptosis in AML leukemic stem-like KG1a cell line by modulation of the intrinsic and extrinsic factors.
Cell death & disease, , Dec-05, Volume: 4 | 2013 |
In vivo effect of triptolide combined with glycyrrhetinic acid on rat cytochrome P450 enzymes.
Yao xue xue bao = Acta pharmaceutica Sinica, , Volume: 48, Issue:7 | 2013 |
[Triptolide combined with irbesartan synergistically blocks podocyte injury in a type 2 diabetes rat model].
Zhonghua nei ke za zhi, , Volume: 51, Issue:2 | 2012 |
Metabolite identification of triptolide by data-dependent accurate mass spectrometric analysis in combination with online hydrogen/deuterium exchange and multiple data-mining techniques.
Rapid communications in mass spectrometry : RCM, , Oct-30, Volume: 25, Issue:20 | 2011 |
[Apoptosis of MR2 cells induced by Tanshinone II A combined with arsenic trioxide].
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, , Volume: 40, Issue:5 | 2009 |
Synergistic effect of triptolide combined with 5-fluorouracil on colon carcinoma.
Postgraduate medical journal, , Volume: 83, Issue:979 | 2007 |
Degradation mechanisms of benzo[a]pyrene and its accumulated metabolites by biodegradation combined with chemical oxidation.
Chemosphere, , Volume: 67, Issue:7 | 2007 |
Natural Sources (10)
| Article | Year |
|---|
Tanshinones inhibit NLRP3 inflammasome activation by alleviating mitochondrial damage to protect against septic and gouty inflammation.
International immunopharmacology, , Volume: 97 | 2021 |
Triptolide: Medicinal chemistry, chemical biology and clinical progress.
European journal of medicinal chemistry, , Aug-15, Volume: 176 | 2019 |
Discovery of thalicthuberine as a novel antimitotic agent from nature that disrupts microtubule dynamics and induces apoptosis in prostate cancer cells.
Cell cycle (Georgetown, Tex.), , Volume: 17, Issue:5 | 2018 |
Downregulation of Sp1 by Minnelide leads to decrease in HSP70 and decrease in tumor burden of gastric cancer.
PloS one, , Volume: 12, Issue:2 | 2017 |
A renal-targeted triptolide aminoglycoside (TPAG) conjugate for lowering systemic toxicities of triptolide.
Fitoterapia, , Volume: 103 | 2015 |
Structural and physiochemical characterization of rhamnolipids produced by Acinetobacter calcoaceticus, Enterobacter asburiae and Pseudomonas aeruginosa in single strain and mixed cultures.
Journal of biotechnology, , Jan-10, Volume: 193 | 2015 |
Triptolide-induced cell death in pancreatic cancer is mediated by O-GlcNAc modification of transcription factor Sp1.
The Journal of biological chemistry, , Nov-22, Volume: 288, Issue:47 | 2013 |
Coexisted components of Salvia miltiorrhiza enhance intestinal absorption of cryptotanshinone via inhibition of the intestinal P-gp.
Phytomedicine : international journal of phytotherapy and phytopharmacology, , Nov-15, Volume: 19, Issue:14 | 2012 |
Degradable rosin-ester-caprolactone graft copolymers.
Biomacromolecules, , Jun-13, Volume: 12, Issue:6 | 2011 |
Biodegradation of phenanthrene by fungi screened from nature.
Pakistan journal of biological sciences : PJBS, , Aug-01, Volume: 10, Issue:15 | 2007 |