4-hydroxyphenylpyruvate dioxygenase

A 4-hydroxyphenylpyruvate dioxygenase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P32754]

EC 1.13.11.27;
4-hydroxyphenylpyruvic acid oxidase;
4HPPD;
HPD;
HPPDase

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
nitisinone	Homo sapiens (human)	Ki	0.0370	1	1

This protein enables 3 target(s):

Target	Category	Definition
4-hydroxyphenylpyruvate dioxygenase activity	molecular function	Catalysis of the reaction: 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2. [EC:1.13.11.27]
protein homodimerization activity	molecular function	Binding to an identical protein to form a homodimer. [GOC:jl]
metal ion binding	molecular function	Binding to a metal ion. [GOC:ai]

This protein is located in 2 target(s):

Target	Category	Definition
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
extracellular exosome	cellular component	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]

This protein is active in 2 target(s):

Target	Category	Definition
Golgi membrane	cellular component	The lipid bilayer surrounding any of the compartments of the Golgi apparatus. [GOC:mah]
endoplasmic reticulum membrane	cellular component	The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah]

This protein is involved in 2 target(s):

Target	Category	Definition
L-phenylalanine catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid. [GOC:go_curators]
tyrosine catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid. [GOC:go_curators]