Page last updated: 2024-08-08 00:08:34
Ubiquitin carboxyl-terminal hydrolase 7
A ubiquitin carboxyl-terminal hydrolase 7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q93009]
Synonyms
EC 3.4.19.12;
Deubiquitinating enzyme 7;
Herpesvirus-associated ubiquitin-specific protease;
Ubiquitin thioesterase 7;
Ubiquitin-specific-processing protease 7
Research
Bioassay Publications (5)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (6)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| ursolic acid | Homo sapiens (human) | IC50 | 7.0000 | 1 | 1 |
| xestoquinone | Homo sapiens (human) | IC50 | 0.1300 | 1 | 1 |
| bardoxolone methyl | Homo sapiens (human) | IC50 | 14.0800 | 1 | 1 |
| p5091 | Homo sapiens (human) | IC50 | 4.2000 | 2 | 2 |
| hbx 41108 | Homo sapiens (human) | IC50 | 0.4200 | 2 | 2 |
| 1-(5-((2,4-difluorophenyl)thio)-4-nitrothiophen-2-yl)ethanone | Homo sapiens (human) | IC50 | 11.7767 | 3 | 3 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| p5091 | Homo sapiens (human) | EC50 | 6.1000 | 2 | 2 |
| 1-(5-((2,4-difluorophenyl)thio)-4-nitrothiophen-2-yl)ethanone | Homo sapiens (human) | EC50 | 4.2000 | 1 | 1 |
Enables
This protein enables 6 target(s):
| Target | Category | Definition |
|---|---|---|
| p53 binding | molecular function | Binding to one of the p53 family of proteins. [GOC:hjd] |
| cysteine-type endopeptidase activity | molecular function | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE] |
| cysteine-type deubiquitinase activity | molecular function | An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated. [GOC:jh2, PMID:30783221] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| deubiquitinase activity | molecular function | An isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated. [GOC:mec, PMID:30783221] |
| K48-linked deubiquitinase activity | molecular function | Hydrolysis of a ubiquitin unit from a ubiquitinated protein linked via the Lys48 residue of ubiquitin. [GOC:bf, GOC:PARL, PMID:22970133] |
Located In
This protein is located in 5 target(s):
| Target | Category | Definition |
|---|---|---|
| nucleus | cellular component | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators] |
| nucleoplasm | cellular component | That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653] |
| chromosome | cellular component | A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. [ISBN:0198547684] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| nuclear body | cellular component | Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins. [GOC:ma, PMID:10330182] |
Active In
This protein is active in 3 target(s):
| Target | Category | Definition |
|---|---|---|
| PML body | cellular component | A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection. [GOC:ma, PMID:10944585] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| nucleus | cellular component | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators] |
Part Of
This protein is part of 1 target(s):
| Target | Category | Definition |
|---|---|---|
| protein-containing complex | cellular component | A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. [GOC:dos, GOC:mah] |
Involved In
This protein is involved in 19 target(s):
| Target | Category | Definition |
|---|---|---|
| transcription-coupled nucleotide-excision repair | biological process | The nucleotide-excision repair process that carries out preferential repair of DNA lesions on the actively transcribed strand of the DNA duplex. In addition, the transcription-coupled nucleotide-excision repair pathway is required for the recognition and repair of a small subset of lesions that are not recognized by the global genome nucleotide excision repair pathway. [PMID:10197977, PMID:11900249] |
| DNA alkylation repair | biological process | The repair of alkylation damage in DNA, e.g. the removal of a non-physiological alkyl group from a nucleobase. This is usually mediated by DNA alkyltransferases. [PMID:10946226, PMID:35543797] |
| proteolysis | biological process | The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. [GOC:bf, GOC:mah] |
| protein ubiquitination | biological process | The process in which one or more ubiquitin groups are added to a protein. [GOC:ai] |
| protein deubiquitination | biological process | The removal of one or more ubiquitin groups from a protein. [GOC:ai] |
| regulation of protein stability | biological process | Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation. [GOC:dph, GOC:mah, GOC:tb] |
| negative regulation of NF-kappaB transcription factor activity | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB. [GOC:dph, GOC:rl, GOC:tb] |
| negative regulation of proteasomal ubiquitin-dependent protein catabolic process | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. [GOC:mah] |
| regulation of circadian rhythm | biological process | Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours. [GOC:dph, GOC:jl, GOC:tb] |
| negative regulation of gene expression via chromosomal CpG island methylation | biological process | An epigenetic gene regulation mechanism that negatively regulates gene expression by methylation of cytosine residues in chromosomal CpG islands. CpG islands are genomic regions that contain a high frequency of the CG dinucleotide associated with the transcription start site of genes. [PMID:11898023, Wikipedia:Cpg_island] |
| negative regulation of gluconeogenesis | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of gluconeogenesis. [GOC:go_curators] |
| rhythmic process | biological process | Any process pertinent to the generation and maintenance of rhythms in the physiology of an organism. [GOC:jid] |
| protein stabilization | biological process | Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation. [GOC:ai] |
| regulation of DNA-binding transcription factor activity | biological process | Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription. [GOC:ai] |
| symbiont-mediated disruption of host cell PML body | biological process | The process in which an organism effects a change that impairs the structure or function of the host PML body. A PML body is a nuclear body that reacts against SP100 auto-antibodies (PML = promyelocytic leukemia). The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:BHF, GOC:jl] |
| regulation of signal transduction by p53 class mediator | biological process | Any process that modulates the frequency, rate or extent of signal transduction by p53 class mediator. [GOC:TermGenie] |
| negative regulation of TORC1 signaling | biological process | Any process that stops, prevents or reduces the frequency, rate or extent of TORC1 signaling. [GO_REF:0000058, GOC:TermGenie, PMID:25366275] |
| regulation of telomere capping | biological process | Any process that modulates the frequency, rate or extent of telomere capping. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892] |
| regulation of retrograde transport, endosome to Golgi | biological process | Any process that modulates the frequency, rate or extent of retrograde transport, endosome to Golgi. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23395371] |