A neutral amino acid transporter A that is encoded in the genome of human. [PRO:DNx, UniProtKB:P43007]
Alanine/serine/cysteine/threonine transporter 1;
ASCT-1;
SATT;
Solute carrier family 1 member 4
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0) | 18.7374 |
| 1990's | 0 (0) | 18.2507 |
| 2000's | 0 (0) | 29.6817 |
| 2010's | 0 (0) | 24.3611 |
| 2020's | 0 (0) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| hydroxyproline | Homo sapiens (human) | IC50 | 1,094.0000 | 2 | 0 |
| serine | Homo sapiens (human) | IC50 | 292.0000 | 1 | 0 |
| glutamine | Homo sapiens (human) | IC50 | 3,373.0000 | 1 | 0 |
| asparagine | Homo sapiens (human) | IC50 | 656.0000 | 1 | 0 |
| 4-hydroxyphenylglycine, (s)-isomer | Homo sapiens (human) | IC50 | 1,661.0000 | 2 | 0 |
| D-serine | Homo sapiens (human) | IC50 | 3,937.0000 | 1 | 0 |
| gamma-glutamine-4-nitroanilide | Homo sapiens (human) | IC50 | 6,000.0000 | 2 | 0 |
| proline | Homo sapiens (human) | IC50 | 2,139.0000 | 1 | 0 |
This protein enables 11 target(s):
| Target | Category | Definition |
|---|---|---|
| chloride channel activity | molecular function | Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. [GOC:mtg_transport, GOC:pr, ISBN:0815340729] |
| amino acid transmembrane transporter activity | molecular function | Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. [GOC:ai, GOC:mtg_transport, ISBN:0815340729] |
| L-alanine transmembrane transporter activity | molecular function | Enables the transfer of L-alanine from one side of a membrane to the other. L-alanine is the L-enantiomer of 2-aminopropanoic acid. [GOC:go_curators, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] |
| L-aspartate transmembrane transporter activity | molecular function | Enables the transfer of L-aspartate from one side of a membrane to the other. L-aspartate is the anion derived from aspartic acid. [GOC:go_curators, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] |
| L-cystine transmembrane transporter activity | molecular function | Enables the transfer of L-cystine from one side of a membrane to the other. [GOC:go_curators, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] |
| L-glutamine transmembrane transporter activity | molecular function | Enables the transfer of L-glutamine from one side of a membrane to the other. L-glutamine is 2-amino-4-carbamoylbutanoic acid. [GOC:ai, GOC:mtg_transport, ISBN:0815340729] |
| L-proline transmembrane transporter activity | molecular function | Enables the transfer of L-proline from one side of a membrane to the other. L-proline is pyrrolidine-2-carboxylic acid. [GOC:ai, GOC:mtg_transport, ISBN:0815340729] |
| L-serine transmembrane transporter activity | molecular function | Enables the transfer of L-serine from one side of a membrane to the other. L-serine is the L-enantiomer of 2-amino-3-hydroxypropanoic acid. [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, RHEA:35031] |
| L-threonine transmembrane transporter activity | molecular function | Enables the transfer of L-threonine from one side of a membrane to the other. L-threonine is (2R*,3S*)-2-amino-3-hydroxybutanoic acid. [GOC:ai, GOC:mtg_transport, ISBN:0815340729] |
| symporter activity | molecular function | Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. [GOC:mtg_transport, ISBN:0815340729, PMID:10839820] |
| L-hydroxyproline transmembrane transporter activity | molecular function | Enables the transfer of L-hydroxyproline from one side of a membrane to the other. [GOC:mah, PMID:14502423] |
This protein is located in 8 target(s):
| Target | Category | Definition |
|---|---|---|
| centrosome | cellular component | A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle. [GOC:mah, ISBN:0198547684] |
| intermediate filament | cellular component | A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: Type I, acidic keratins; Type II, basic keratins; Type III, including desmin, vimentin and others; Type IV, neurofilaments and related filaments; and Type V, lamins. [http://www.cytochemistry.net/Cell-biology/intermediate_filaments.htm, ISBN:0198506732] |
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| cell surface | cellular component | The external part of the cell wall and/or plasma membrane. [GOC:jl, GOC:mtg_sensu, GOC:sm] |
| membrane | cellular component | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
| melanosome | cellular component | A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells. [GOC:jl, PMID:11584301] |
| synapse | cellular component | The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110] |
| extracellular exosome | cellular component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
This protein is involved in 17 target(s):
| Target | Category | Definition |
|---|---|---|
| amino acid transport | biological process | The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai] |
| glutamine transport | biological process | The directed movement of glutamine, 2-amino-4-carbamoylbutanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai] |
| L-alanine transport | biological process | The directed movement of L-alanine, the L-enantiomer of 2-aminopropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai, GOC:jsg, GOC:mah] |
| L-cystine transport | biological process | The directed movement of L-cystine (also known as dicysteine) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:go_curators, ISBN:0198506732] |
| proline transport | biological process | The directed movement of proline, pyrrolidine-2-carboxylic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai] |
| L-serine transport | biological process | The directed movement of L-serine, the L-enantiomer of 2-amino-3-hydroxypropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai, GOC:jsg, GOC:mah] |
| threonine transport | biological process | The directed movement of threonine, (2R*,3S*)-2-amino-3-hydroxybutanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai] |
| hydroxyproline transport | biological process | The directed movement of hydroxyproline into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah, PMID:14502423] |
| synaptic transmission, glutamatergic | biological process | The vesicular release of glutamate from a presynapse, across a chemical synapse, the subsequent activation of glutamate receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. [GOC:dos] |
| proline transmembrane transport | biological process | The directed movement of proline, pyrrolidine-2-carboxylic acid, across a membrane by means of some agent such as a transporter or pore. [GOC:vw] |
| cognition | biological process | The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory. [ISBN:0721619908] |
| L-aspartate import across plasma membrane | biological process | The directed movement of L-aspartate from outside of a cell, across the plasma membrane and into the cytosol. [GO_REF:0000069, PMID:7914198] |
| transport across blood-brain barrier | biological process | The directed movement of substances (e.g. macromolecules, small molecules, ions) through the blood-brain barrier. [GOC:aruk, GOC:bc, PMID:29377008] |
| chloride transmembrane transport | biological process | The process in which chloride is transported across a membrane. [GOC:TermGenie, GOC:vw] |
| L-serine import across plasma membrane | biological process | The directed movement of L-serine into a cell. [GO_REF:0000075, GOC:TermGenie, PMID:23895341] |
| L-alanine import across plasma membrane | biological process | The directed import of L-alanine from the extracellular region across the plasma membrane and into the cytosol. [GO_REF:0000075, GOC:kmv, GOC:TermGenie, PMID:21097500] |
| L-glutamate transmembrane transport | biological process | The directed movement of L-glutamate across a membrane by means of some agent such as a transporter or a pore. [PMID:21307582] |