Page last updated: 2024-08-07 15:36:09
3-hydroxy-3-methylglutaryl-coenzyme A reductase
A 3-hydroxy-3-methylglutaryl-coenzyme A reductase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P04035]
Synonyms
HMG-CoA reductase;
EC 1.1.1.34
Research
Bioassay Publications (23)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (30.43) | 18.2507 |
| 2000's | 7 (30.43) | 29.6817 |
| 2010's | 7 (30.43) | 24.3611 |
| 2020's | 2 (8.70) | 2.80 |
Compounds (20)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| meglutol | Homo sapiens (human) | IC50 | 4.0000 | 1 | 1 |
| meglutol | Homo sapiens (human) | Ki | 0.0235 | 1 | 1 |
| cisapride | Homo sapiens (human) | IC50 | 3.3700 | 1 | 0 |
| vorinostat | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| lovastatin | Homo sapiens (human) | IC50 | 4.0109 | 10 | 9 |
| simvastatin | Homo sapiens (human) | IC50 | 0.7843 | 8 | 7 |
| simvastatin | Homo sapiens (human) | Ki | 34.0013 | 2 | 2 |
| pravastatin | Homo sapiens (human) | IC50 | 0.1452 | 3 | 2 |
| atorvastatin | Homo sapiens (human) | IC50 | 0.0064 | 3 | 2 |
| atorvastatin | Homo sapiens (human) | Ki | 0.0062 | 1 | 1 |
| mevastatin | Homo sapiens (human) | IC50 | 0.0483 | 4 | 3 |
| 25-hydroxycholesterol | Homo sapiens (human) | IC50 | 0.3000 | 1 | 1 |
| cerivastatin | Homo sapiens (human) | IC50 | 0.0050 | 2 | 1 |
| rosuvastatin | Homo sapiens (human) | IC50 | 0.0045 | 3 | 3 |
| rosuvastatin | Homo sapiens (human) | Ki | 35.5004 | 2 | 2 |
| alpha-asarone | Homo sapiens (human) | IC50 | 2.9482 | 2 | 2 |
| hr 780 | Homo sapiens (human) | IC50 | 0.0050 | 1 | 1 |
| nk 104 | Homo sapiens (human) | IC50 | 8.9000 | 1 | 1 |
| (6E)-7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid | Homo sapiens (human) | IC50 | 0.0142 | 2 | 1 |
| tannins | Homo sapiens (human) | IC50 | 3.1270 | 1 | 0 |
| pravastatin sodium | Homo sapiens (human) | IC50 | 0.7000 | 2 | 2 |
| 7-oxo-ganoderic acid z | Homo sapiens (human) | IC50 | 22.3000 | 1 | 1 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| 25-hydroxycholesterol | Homo sapiens (human) | EC50 | 0.6300 | 1 | 1 |
| sk&f 99085 | Homo sapiens (human) | EC50 | 0.6730 | 2 | 2 |
| rosuvastatin | Homo sapiens (human) | Kd | 0.0170 | 1 | 1 |
| sr 12813 | Homo sapiens (human) | EC50 | 1.1000 | 1 | 1 |
Enables
This protein enables 5 target(s):
| Target | Category | Definition |
|---|---|---|
| hydroxymethylglutaryl-CoA reductase (NADPH) activity | molecular function | Catalysis of the reaction: (R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 H+ + 2 NADPH. [PMID:29224355, RHEA:15989] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| GTPase regulator activity | molecular function | Binds to and modulates the activity of a GTPase. [GOC:mah] |
| NADPH binding | molecular function | Binding to the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions. [GOC:mah] |
| coenzyme A binding | molecular function | Binding to coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. [GOC:krc, ISBN:0198547684] |
Located In
This protein is located in 3 target(s):
| Target | Category | Definition |
|---|---|---|
| peroxisomal membrane | cellular component | The lipid bilayer surrounding a peroxisome. [GOC:mah] |
| endoplasmic reticulum | cellular component | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732] |
| endoplasmic reticulum membrane | cellular component | The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah] |
Active In
This protein is active in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| endoplasmic reticulum membrane | cellular component | The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah] |
| peroxisomal membrane | cellular component | The lipid bilayer surrounding a peroxisome. [GOC:mah] |
Involved In
This protein is involved in 10 target(s):
| Target | Category | Definition |
|---|---|---|
| cholesterol biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. [GOC:ai] |
| visual learning | biological process | Any process in an organism in which a change in behavior of an individual occurs in response to repeated exposure to a visual cue. [GOC:jid, ISBN:0582227089] |
| coenzyme A metabolic process | biological process | The chemical reactions and pathways involving coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. [ISBN:0198547684] |
| negative regulation of protein catabolic process | biological process | Any process that stops, prevents or reduces the frequency, rate or extent of protein catabolic process. [GO_REF:0000058, GOC:kmv, GOC:obol, GOC:TermGenie, PMID:24785082] |
| negative regulation of protein secretion | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell. [GOC:ai] |
| long-term synaptic potentiation | biological process | A process that modulates synaptic plasticity such that synapses are changed resulting in the increase in the rate, or frequency of synaptic transmission at the synapse. [GOC:dgh, GOC:dph] |
| regulation of ERK1 and ERK2 cascade | biological process | Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. [GOC:add, ISBN:0121245462, ISBN:0896039986] |
| negative regulation of amyloid-beta clearance | biological process | Any process that stops, prevents or reduces the frequency, rate or extent of amyloid-beta clearance. [GOC:BHF, GOC:TermGenie] |
| isoprenoid biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. [ISBN:0198506732] |
| sterol biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. [GOC:go_curators] |