| Assay ID | Title | Year | Journal | Article |
|---|
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | | | |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID1745845 | Primary qHTS for Inhibitors of ATXN expression | | | |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID89021 | Inhibition of the production of Interleukin-1-beta from human peripheral blood monocytes stimulated with lipopolysaccharide (LPS) | 1993 | Journal of medicinal chemistry, May-14, Volume: 36, Issue:10
| 2'-substituted chalcone derivatives as inhibitors of interleukin-1 biosynthesis. |
| AID1272634 | Cytoprotective activity against amyloid beta-induced oxidative stress in mouse Neuro2a cells assessed as cell viability at 250 uM after 6 hrs by MTT assay | 2016 | Bioorganic & medicinal chemistry, Feb-15, Volume: 24, Issue:4
| Hydroxylated chalcones with dual properties: Xanthine oxidase inhibitors and radical scavengers. |
| AID1167300 | Antioxidant activity assessed as DPPH radical scavenging activity incubated at room temperature for 20 mins by UV-visible spectrophotometry | 2014 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 24, Issue:21
| Design, synthesis and exploring the quantitative structure-activity relationship of some antioxidant flavonoid analogues. |
| AID295382 | Cytotoxicity against human HT29 cells ATCC HTB38 in aerobic condition assessed as survival at 100 uM by sulforhodamine assay | 2007 | Bioorganic & medicinal chemistry, May-15, Volume: 15, Issue:10
| Synthetic chalcones, flavanones, and flavones as antitumoral agents: biological evaluation and structure-activity relationships. |
| AID513968 | Mutagenic activity in Salmonella typhimurium TA98 assessed as crosslinking-associated increase in number of revertants at 25 ug/plate after 48 hrs by Ames test | 2010 | Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14
| Identification of chalcones as in vivo liver monofunctional phase II enzymes inducers. |
| AID1697932 | Antiproliferative activity against human THP-1 cells assessed as reduction in cell viability after 72 hrs by MTS assay | 2020 | Journal of natural products, 10-23, Volume: 83, Issue:10
| Natural and Semisynthetic Chalcones as Dual FLT3 and Microtubule Polymerization Inhibitors. |
| AID1142531 | Inhibition of BChE (unknown origin) using BCh iodide as substrate preincubated for 15 mins prior to substrate addition measured after 10 mins by Ellman's method | 2014 | European journal of medicinal chemistry, Jun-10, Volume: 80 | Dual inhibition of the α-glucosidase and butyrylcholinesterase studied by molecular field topology analysis. |
| AID361221 | Cytotoxicity against HGF cells | 2001 | Journal of natural products, Feb, Volume: 64, Issue:2
| Cytotoxic flavonoids with isoprenoid groups from Morus mongolica. |
| AID1186727 | Cytotoxicity against human WM115 cells by MTT assay | 2014 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 24, Issue:17
| Cytotoxic activity of substituted chalcones in terms of molecular electronic properties. |
| AID1461517 | Inhibition of bovine milk xanthine oxidase pre-incubated for 30 mins followed by xanthine addition and measured every 30 secs for 5 mins by spectrophotometry | 2017 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 27, Issue:15
| Synthesis and evaluation of hydroxychalcones as multifunctional non-purine xanthine oxidase inhibitors for the treatment of hyperuricemia. |
| AID361219 | Cytotoxicity against human HSC2 cells | 2001 | Journal of natural products, Feb, Volume: 64, Issue:2
| Cytotoxic flavonoids with isoprenoid groups from Morus mongolica. |
| AID513962 | Induction of quinone reductase activity in rat liver at 22.5 mg/kg, po qd | 2010 | Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14
| Identification of chalcones as in vivo liver monofunctional phase II enzymes inducers. |
| AID1285404 | Induction of quinone reductase activity in cytosolic fraction of Wistar rat liver at 15 mg/kg/day, po for two weeks using 2,6-DCIP as substrate measured for 1 min relative to control | 2016 | Bioorganic & medicinal chemistry, Apr-15, Volume: 24, Issue:8
| In vivo phase II-enzymes inducers, as potential chemopreventive agents, based on the chalcone and furoxan skeletons. |
| AID513975 | Toxicity in Sprague-Dawley rat assessed as haemoglobin level at 250 mg/kg, po (RVb = 15.1 +/- 4.1 g/L) | 2010 | Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14
| Identification of chalcones as in vivo liver monofunctional phase II enzymes inducers. |
| AID1697934 | Antiproliferative activity against human MV4-11 cells assessed as reduction in cell viability at 50 uM after 72 hrs by MTS assay relative to control | 2020 | Journal of natural products, 10-23, Volume: 83, Issue:10
| Natural and Semisynthetic Chalcones as Dual FLT3 and Microtubule Polymerization Inhibitors. |
| AID1285421 | Toxicity in Wistar rat assessed as change in behaviors at 15 mg/kg/day, po for two weeks | 2016 | Bioorganic & medicinal chemistry, Apr-15, Volume: 24, Issue:8
| In vivo phase II-enzymes inducers, as potential chemopreventive agents, based on the chalcone and furoxan skeletons. |
| AID1076733 | Growth inhibition of cisplatin-resistant human A2780cis cells after 7 days by crystal violet staining based clonogenic assay | 2014 | Bioorganic & medicinal chemistry, Mar-15, Volume: 22, Issue:6
| Polyphenols bearing cinnamaldehyde scaffold showing cell growth inhibitory effects on the cisplatin-resistant A2780/Cis ovarian cancer cells. |
| AID638551 | Inhibition of MRP1 overexpressed in human 2008 MRP1 cells assessed as calcein AM accumulation at 10 uM by fluorimetry | 2012 | Bioorganic & medicinal chemistry, Jan-01, Volume: 20, Issue:1
| Investigation of chalcones and benzochalcones as inhibitors of breast cancer resistance protein. |
| AID144377 | Ability to induce NAD(P)H quinone reductase activity in cultured Hepa 1c1c7 murine hepatoma cells. | 1998 | Journal of medicinal chemistry, Dec-17, Volume: 41, Issue:26
| Chemoprotective properties of phenylpropenoids, bis(benzylidene)cycloalkanones, and related Michael reaction acceptors: correlation of potencies as phase 2 enzyme inducers and radical scavengers. |
| AID1461521 | Antioxidant activity assessed as DPPH free radical scavenging activity incubated for 30 mins at 2000 uM | 2017 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 27, Issue:15
| Synthesis and evaluation of hydroxychalcones as multifunctional non-purine xanthine oxidase inhibitors for the treatment of hyperuricemia. |
| AID513970 | Mutagenic activity in Salmonella typhimurium TA98 assessed as crosslinking-associated increase in number of revertants at 225 ug/plate after 48 hrs by Ames test | 2010 | Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14
| Identification of chalcones as in vivo liver monofunctional phase II enzymes inducers. |
| AID295381 | Cytotoxicity against human MCF7 cells ATCC HTB38 in aerobic condition assessed as survival at 100 uM by sulforhodamine assay | 2007 | Bioorganic & medicinal chemistry, May-15, Volume: 15, Issue:10
| Synthetic chalcones, flavanones, and flavones as antitumoral agents: biological evaluation and structure-activity relationships. |
| AID418269 | Cytotoxicity against mouse RAW264.7 cells assessed as cell viability at 10 uM by MTT assay | 2009 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 19, Issue:6
| Inhibitory activity of prostaglandin E2 production by the synthetic 2'-hydroxychalcone analogues: Synthesis and SAR study. |
| AID1697930 | Antiproliferative activity against human MOLM-13 cells assessed as reduction in cell viability after 72 hrs by MTS assay | 2020 | Journal of natural products, 10-23, Volume: 83, Issue:10
| Natural and Semisynthetic Chalcones as Dual FLT3 and Microtubule Polymerization Inhibitors. |
| AID548110 | Antiparasitic activity against Trypanosoma cruzi T2 epimastigotes assessed as growth inhibition at 25 uM after 5 days | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12
| Massive screening yields novel and selective Trypanosoma cruzi triosephosphate isomerase dimer-interface-irreversible inhibitors with anti-trypanosomal activity. |
| AID513964 | Induction glutathione-CYP1A1 in rat liver at 22.5 mg/kg, po qd by EROD assay | 2010 | Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14
| Identification of chalcones as in vivo liver monofunctional phase II enzymes inducers. |
| AID1142530 | Inhibition of yeast alpha-glucosidase type 3 using p-nitrophenyl-alpha-D-glucopyranoside as substrate preincubated with substrate for 5 mins prior to enzyme challenge for 30 mins by absorbance analysis | 2014 | European journal of medicinal chemistry, Jun-10, Volume: 80 | Dual inhibition of the α-glucosidase and butyrylcholinesterase studied by molecular field topology analysis. |
| AID418267 | Inhibition of COX2-mediated PGE2 production in LPS-stimulated mouse RAW264.7 cells at 10 uM by enzyme immunoassay | 2009 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 19, Issue:6
| Inhibitory activity of prostaglandin E2 production by the synthetic 2'-hydroxychalcone analogues: Synthesis and SAR study. |
| AID1285405 | Induction of glutathione S-transferase activity in cytosolic fraction of Wistar rat liver at 15 mg/kg/day, po for two weeks using CDNB as substrate measured for 1 min relative to control | 2016 | Bioorganic & medicinal chemistry, Apr-15, Volume: 24, Issue:8
| In vivo phase II-enzymes inducers, as potential chemopreventive agents, based on the chalcone and furoxan skeletons. |
| AID548113 | Inhibition of Trypanosoma cruzi triosephosphate isomerase at 400 uM after 2 hrs | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12
| Massive screening yields novel and selective Trypanosoma cruzi triosephosphate isomerase dimer-interface-irreversible inhibitors with anti-trypanosomal activity. |
| AID295383 | Growth inhibition of TK10 cells by sulforhodamine assay | 2007 | Bioorganic & medicinal chemistry, May-15, Volume: 15, Issue:10
| Synthetic chalcones, flavanones, and flavones as antitumoral agents: biological evaluation and structure-activity relationships. |
| AID513957 | Cytotoxicity against human MCF7 cells | 2010 | Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14
| Identification of chalcones as in vivo liver monofunctional phase II enzymes inducers. |
| AID1697936 | Antiproliferative activity against human K562 cells assessed as reduction in cell viability at 50 uM after 72 hrs by MTS assay relative to control | 2020 | Journal of natural products, 10-23, Volume: 83, Issue:10
| Natural and Semisynthetic Chalcones as Dual FLT3 and Microtubule Polymerization Inhibitors. |
| AID513976 | Toxicity in Sprague-Dawley rat assessed as glutamic-pyruvate level at 250 mg/kg, po (RVb = 22.8 +/-13.2 U/L) | 2010 | Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14
| Identification of chalcones as in vivo liver monofunctional phase II enzymes inducers. |
| AID513956 | Induction of quinone reductase activity in rat liver at 15 mg/kg, po qd | 2010 | Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14
| Identification of chalcones as in vivo liver monofunctional phase II enzymes inducers. |
| AID513977 | Toxicity in Sprague-Dawley rat assessed as glutamic-oxalate transaminase level at 250 mg/kg, po (RVb = 71.4 +/- 7.8 U/L) | 2010 | Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14
| Identification of chalcones as in vivo liver monofunctional phase II enzymes inducers. |
| AID1697941 | Inhibition of FLT3 ITD mutant in human MV4-11 cells assessed as inhibition of ERK phosphorylation at 25 to 50 uM incubated for 2 hrs by immunoblotting analysis | 2020 | Journal of natural products, 10-23, Volume: 83, Issue:10
| Natural and Semisynthetic Chalcones as Dual FLT3 and Microtubule Polymerization Inhibitors. |
| AID1697944 | Inhibition of FLT3 (unknown origin) at 100 uM in presence of ATP relative to control | 2020 | Journal of natural products, 10-23, Volume: 83, Issue:10
| Natural and Semisynthetic Chalcones as Dual FLT3 and Microtubule Polymerization Inhibitors. |
| AID183256 | Inhibition of lipid peroxidation in rat liver microsomes at 1 uM | 1993 | Journal of medicinal chemistry, Nov-26, Volume: 36, Issue:24
| 3,4-Dihydroxychalcones as potent 5-lipoxygenase and cyclooxygenase inhibitors. |
| AID513971 | Mutagenic activity in Salmonella Typhimurium TA98 assessed as crosslinking-associated increase in number of revertants at 20 ug/plate after 48 hrs by Ames test | 2010 | Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14
| Identification of chalcones as in vivo liver monofunctional phase II enzymes inducers. |
| AID513958 | Cytotoxicity against human TK10 cells | 2010 | Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14
| Identification of chalcones as in vivo liver monofunctional phase II enzymes inducers. |
| AID295386 | Growth inhibition of HK2 cells by sulforhodamine assay | 2007 | Bioorganic & medicinal chemistry, May-15, Volume: 15, Issue:10
| Synthetic chalcones, flavanones, and flavones as antitumoral agents: biological evaluation and structure-activity relationships. |
| AID1186726 | Cytotoxicity against human NALM6 cells by MTT assay | 2014 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 24, Issue:17
| Cytotoxic activity of substituted chalcones in terms of molecular electronic properties. |
| AID513961 | Induction glutathione-CYP1A1 in rat liver at 15 mg/kg, po qd by EROD assay | 2010 | Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14
| Identification of chalcones as in vivo liver monofunctional phase II enzymes inducers. |
| AID1697931 | Antiproliferative activity against human MV4-11 cells assessed as reduction in cell viability after 72 hrs by MTS assay | 2020 | Journal of natural products, 10-23, Volume: 83, Issue:10
| Natural and Semisynthetic Chalcones as Dual FLT3 and Microtubule Polymerization Inhibitors. |
| AID513960 | Induction glutathione-S-transferase activity in rat liver at 15 mg/kg, po qd | 2010 | Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14
| Identification of chalcones as in vivo liver monofunctional phase II enzymes inducers. |
| AID670957 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 at 256 ug/ml after 24 hrs by disc diffusion method | 2012 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14
| Synthesis and anti Methicillin resistant Staphylococcus aureus activity of substituted chalcones alone and in combination with non-beta-lactam antibiotics. |
| AID1285420 | Toxicity in Wistar rat assessed as change in body weight at 15 mg/kg/day, po for two weeks | 2016 | Bioorganic & medicinal chemistry, Apr-15, Volume: 24, Issue:8
| In vivo phase II-enzymes inducers, as potential chemopreventive agents, based on the chalcone and furoxan skeletons. |
| AID638477 | Inhibition of BCRP in human MCF7/MX cells assessed as Hoechst 33342 accumulation preincubated for 30 mins by Fluorometry | 2012 | Bioorganic & medicinal chemistry, Jan-01, Volume: 20, Issue:1
| Investigation of chalcones and benzochalcones as inhibitors of breast cancer resistance protein. |
| AID513963 | Induction glutathione-S-transferase activity in rat liver at 22.5 mg/kg, po qd | 2010 | Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14
| Identification of chalcones as in vivo liver monofunctional phase II enzymes inducers. |
| AID295380 | Cytotoxicity against human TK10 cells in aerobic condition assessed as survival at 100 uM by sulforhodamine assay | 2007 | Bioorganic & medicinal chemistry, May-15, Volume: 15, Issue:10
| Synthetic chalcones, flavanones, and flavones as antitumoral agents: biological evaluation and structure-activity relationships. |
| AID1543107 | Selectivity index, ratio of CC50 for cytotoxicity in mouse NCTC-929 cells to EC50 for Antitrypanosomal activity against Trypanosoma cruzi trypomastigotes infected in LLC-MK2-ATCC CCL7 cells | 2019 | Bioorganic & medicinal chemistry letters, 06-15, Volume: 29, Issue:12
| Structure-activity relationship study of antitrypanosomal chalcone derivatives using multivariate analysis. |
| AID7118 | In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determined at 100 uM | 1993 | Journal of medicinal chemistry, Nov-26, Volume: 36, Issue:24
| 3,4-Dihydroxychalcones as potent 5-lipoxygenase and cyclooxygenase inhibitors. |
| AID513967 | Mutagenic activity in Salmonella typhimurium TA98 assessed as crosslinking-associated increase in number of revertants at 8 ug/plate after 48 hrs by Ames test | 2010 | Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14
| Identification of chalcones as in vivo liver monofunctional phase II enzymes inducers. |
| AID1543106 | Cytotoxicity in mouse NCTC-929 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay | 2019 | Bioorganic & medicinal chemistry letters, 06-15, Volume: 29, Issue:12
| Structure-activity relationship study of antitrypanosomal chalcone derivatives using multivariate analysis. |
| AID513966 | Mutagenic activity in Salmonella typhimurium TA98 assessed as crosslinking-associated increase in number of revertants at 3 ug/plate after 48 hrs by Ames test | 2010 | Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14
| Identification of chalcones as in vivo liver monofunctional phase II enzymes inducers. |
| AID513974 | Toxicity in Sprague-Dawley rat assessed as leucocyte level at 250 mg/kg, po (RVb = 200 +/- 1500 /uL) | 2010 | Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14
| Identification of chalcones as in vivo liver monofunctional phase II enzymes inducers. |
| AID295385 | Growth inhibition of HT29 cells by sulforhodamine assay | 2007 | Bioorganic & medicinal chemistry, May-15, Volume: 15, Issue:10
| Synthetic chalcones, flavanones, and flavones as antitumoral agents: biological evaluation and structure-activity relationships. |
| AID1272633 | Antioxidant activity assessed as DPPH radical scavenging activity by measuring remaining DPPH level at 20 uM after 30 mins by plate reader analysis | 2016 | Bioorganic & medicinal chemistry, Feb-15, Volume: 24, Issue:4
| Hydroxylated chalcones with dual properties: Xanthine oxidase inhibitors and radical scavengers. |
| AID295384 | Growth inhibition of MCF7 cells by sulforhodamine assay | 2007 | Bioorganic & medicinal chemistry, May-15, Volume: 15, Issue:10
| Synthetic chalcones, flavanones, and flavones as antitumoral agents: biological evaluation and structure-activity relationships. |
| AID513959 | Cytotoxicity against human HT-29 cells | 2010 | Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14
| Identification of chalcones as in vivo liver monofunctional phase II enzymes inducers. |
| AID1285422 | Toxicity in Wistar rat assessed as survival at 15 mg/kg/day, po for two weeks | 2016 | Bioorganic & medicinal chemistry, Apr-15, Volume: 24, Issue:8
| In vivo phase II-enzymes inducers, as potential chemopreventive agents, based on the chalcone and furoxan skeletons. |
| AID361220 | Cytotoxicity against human HSG cells | 2001 | Journal of natural products, Feb, Volume: 64, Issue:2
| Cytotoxic flavonoids with isoprenoid groups from Morus mongolica. |
| AID513978 | Toxicity in Sprague-Dawley rat assessed as change in body weight at 250 mg/kg, po | 2010 | Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14
| Identification of chalcones as in vivo liver monofunctional phase II enzymes inducers. |
| AID443496 | Inhibition of TNFalpha induced NF-kappaB activation in human A549 cells by luciferase reporter gene assay | 2009 | Journal of medicinal chemistry, Nov-26, Volume: 52, Issue:22
| Structure-activity relationship studies of chalcone leading to 3-hydroxy-4,3',4',5'-tetramethoxychalcone and its analogues as potent nuclear factor kappaB inhibitors and their anticancer activities. |
| AID638550 | Inhibition of MDR1 in human A2780adr cells assessed as calcein AM accumulation at 10 uM by fluorimetry | 2012 | Bioorganic & medicinal chemistry, Jan-01, Volume: 20, Issue:1
| Investigation of chalcones and benzochalcones as inhibitors of breast cancer resistance protein. |
| AID638478 | Inhibition of human BCRP expressed in MDCK2 cells assessed as Hoechst 33342 accumulation preincubated for 30 mins by fluorimetry | 2012 | Bioorganic & medicinal chemistry, Jan-01, Volume: 20, Issue:1
| Investigation of chalcones and benzochalcones as inhibitors of breast cancer resistance protein. |
| AID1186725 | Cytotoxicity against human HL60 cells by MTT assay | 2014 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 24, Issue:17
| Cytotoxic activity of substituted chalcones in terms of molecular electronic properties. |
| AID1543105 | Antitrypanosomal activity against Trypanosoma cruzi Y trypomastigotes infected in LLC-MK2-ATCC CCL7 cells assessed as reduction in parasite growth incubated for 24 hrs by Alamar blue dye based assay | 2019 | Bioorganic & medicinal chemistry letters, 06-15, Volume: 29, Issue:12
| Structure-activity relationship study of antitrypanosomal chalcone derivatives using multivariate analysis. |
| AID670950 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus ATCC 25923 at 256 ug/ml after 24 hrs by disc diffusion method | 2012 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14
| Synthesis and anti Methicillin resistant Staphylococcus aureus activity of substituted chalcones alone and in combination with non-beta-lactam antibiotics. |
| AID1272632 | Inhibition of bovine xanthine oxidase assessed as conversion of xanthine to uric acid by spectroscopic analysis | 2016 | Bioorganic & medicinal chemistry, Feb-15, Volume: 24, Issue:4
| Hydroxylated chalcones with dual properties: Xanthine oxidase inhibitors and radical scavengers. |
| AID759072 | Cytotoxicity against human HCT116 cells assessed as cell viability at 15 uM after 48 hrs by MTT assay relative to control | 2013 | European journal of medicinal chemistry, Jul, Volume: 65 | Superior anticancer activity of halogenated chalcones and flavonols over the natural flavonol quercetin. |
| AID102612 | The compound was tested for antiproliferative activity against MCF-7 human breast cancer cells | 2001 | Bioorganic & medicinal chemistry letters, Dec-17, Volume: 11, Issue:24
| Flavonoids: structural requirements for antiproliferative activity on breast cancer cells. |
| AID161175 | Inhibition of Prostaglandin G/H synthase activity in sheep seminal vesicle was determined 100 uM | 1993 | Journal of medicinal chemistry, Nov-26, Volume: 36, Issue:24
| 3,4-Dihydroxychalcones as potent 5-lipoxygenase and cyclooxygenase inhibitors. |
| AID1697933 | Antiproliferative activity against human MV4-11 cells assessed as reduction in cell viability at 25 uM after 72 hrs by MTS assay relative to control | 2020 | Journal of natural products, 10-23, Volume: 83, Issue:10
| Natural and Semisynthetic Chalcones as Dual FLT3 and Microtubule Polymerization Inhibitors. |
| AID513969 | Mutagenic activity in Salmonella typhimurium TA98 assessed as crosslinking-associated increase in number of revertants at 75 ug/plate after 48 hrs by Ames test | 2010 | Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14
| Identification of chalcones as in vivo liver monofunctional phase II enzymes inducers. |
| AID1461520 | Antioxidant activity assessed as ABTS free radical scavenging activity by measuring trolox equivalents after 6 mins | 2017 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 27, Issue:15
| Synthesis and evaluation of hydroxychalcones as multifunctional non-purine xanthine oxidase inhibitors for the treatment of hyperuricemia. |
| AID548112 | Inhibition of Trypanosoma cruzi triosephosphate isomerase at 100 uM after 2 hrs | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12
| Massive screening yields novel and selective Trypanosoma cruzi triosephosphate isomerase dimer-interface-irreversible inhibitors with anti-trypanosomal activity. |
| AID513965 | Induction of quinone reductase activity in human MCF7 cells | 2010 | Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14
| Identification of chalcones as in vivo liver monofunctional phase II enzymes inducers. |
| AID310815 | Antibacterial activity against Mycobacterium tuberculosis H37Rv at 12.5 ug/mL | 2007 | European journal of medicinal chemistry, Feb, Volume: 42, Issue:2
| A review of anti-infective and anti-inflammatory chalcones. |
| AID661075 | Antidiabetic activity in mouse 3T3L1 cells assessed as decrease in glucose consumption from cell culture medium using 450 mg/dL D-glucose at 30 ug/mL after 24 hrs (Rvb = 310 +/- 4 mg/dl) | 2012 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
| Synthesis of chalcone derivatives as potential anti-diabetic agents. |
| AID1697935 | Antiproliferative activity against human K562 cells assessed as reduction in cell viability at 25 uM after 72 hrs by MTS assay relative to control | 2020 | Journal of natural products, 10-23, Volume: 83, Issue:10
| Natural and Semisynthetic Chalcones as Dual FLT3 and Microtubule Polymerization Inhibitors. |
| AID361222 | Selectivity ratio of CC50 for HGF cells to CC50 for human HSC2 cells | 2001 | Journal of natural products, Feb, Volume: 64, Issue:2
| Cytotoxic flavonoids with isoprenoid groups from Morus mongolica. |
| AID548108 | Selectivity for Trypanosoma cruzi triosephosphate isomerase over human triosephosphate isomerase | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12
| Massive screening yields novel and selective Trypanosoma cruzi triosephosphate isomerase dimer-interface-irreversible inhibitors with anti-trypanosomal activity. |
| AID1799680 | Enzyme Inhibition Assay from Article 10.1080/14756360400015231: \\Synthesis and inhibitory potential towards acetylcholinesterase, butyrylcholinesterase and lipoxygenase of some variably substituted chalcones.\\ | 2005 | Journal of enzyme inhibition and medicinal chemistry, Feb, Volume: 20, Issue:1
| Synthesis and inhibitory potential towards acetylcholinesterase, butyrylcholinesterase and lipoxygenase of some variably substituted chalcones. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |