Page last updated: 2024-10-25

clofazimine and Necrosis

clofazimine has been researched along with Necrosis in 2 studies

Clofazimine: A fat-soluble riminophenazine dye used for the treatment of leprosy. It has been used investigationally in combination with other antimycobacterial drugs to treat Mycobacterium avium infections in AIDS patients. Clofazimine also has a marked anti-inflammatory effect and is given to control the leprosy reaction, erythema nodosum leprosum. (From AMA Drug Evaluations Annual, 1993, p1619)
clofazimine : 3-Isopropylimino-3,5-dihydro-phenazine in which the hydrogen at position 5 is substituted substituted by a 4-chlorophenyl group, and that at position 2 is substituted by a (4-chlorophenyl)amino group. A dark red crystalline solid, clofazimine is an antimycobacterial and is one of the main drugs used for the treatment of multi-bacillary leprosy. However, it can cause red/brown discolouration of the skin, so other treatments are often preferred in light-skinned patients.

Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (50.00)24.3611
2020's1 (50.00)2.80

Authors

AuthorsStudies
Kokesch-Himmelreich, J1
Treu, A1
Race, AM1
Walter, K1
Hölscher, C1
Römpp, A1
Irwin, SM1
Gruppo, V1
Brooks, E1
Gilliland, J1
Scherman, M1
Reichlen, MJ1
Leistikow, R1
Kramnik, I1
Nuermberger, EL1
Voskuil, MI1
Lenaerts, AJ1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Pharmacometrics to Advance Novel Regimens for Drug-resistant Tuberculosis[NCT03827811]625 participants (Anticipated)Observational2020-01-30Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

2 other studies available for clofazimine and Necrosis

ArticleYear
Do Anti-tuberculosis Drugs Reach Their Target?─High-Resolution Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging Provides Information on Drug Penetration into Necrotic Granulomas.
    Analytical chemistry, 2022, 04-12, Volume: 94, Issue:14

    Topics: Animals; Antitubercular Agents; Clofazimine; Granuloma; Humans; Lasers; Mice; Mycobacterium tubercul

2022
Limited activity of clofazimine as a single drug in a mouse model of tuberculosis exhibiting caseous necrotic granulomas.
    Antimicrobial agents and chemotherapy, 2014, Volume: 58, Issue:7

    Topics: Animals; Antitubercular Agents; Bacterial Load; Clofazimine; Disease Models, Animal; Female; Granulo

2014