clofazimine has been researched along with Necrosis in 2 studies
Clofazimine: A fat-soluble riminophenazine dye used for the treatment of leprosy. It has been used investigationally in combination with other antimycobacterial drugs to treat Mycobacterium avium infections in AIDS patients. Clofazimine also has a marked anti-inflammatory effect and is given to control the leprosy reaction, erythema nodosum leprosum. (From AMA Drug Evaluations Annual, 1993, p1619)
clofazimine : 3-Isopropylimino-3,5-dihydro-phenazine in which the hydrogen at position 5 is substituted substituted by a 4-chlorophenyl group, and that at position 2 is substituted by a (4-chlorophenyl)amino group. A dark red crystalline solid, clofazimine is an antimycobacterial and is one of the main drugs used for the treatment of multi-bacillary leprosy. However, it can cause red/brown discolouration of the skin, so other treatments are often preferred in light-skinned patients.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kokesch-Himmelreich, J | 1 |
| Treu, A | 1 |
| Race, AM | 1 |
| Walter, K | 1 |
| Hölscher, C | 1 |
| Römpp, A | 1 |
| Irwin, SM | 1 |
| Gruppo, V | 1 |
| Brooks, E | 1 |
| Gilliland, J | 1 |
| Scherman, M | 1 |
| Reichlen, MJ | 1 |
| Leistikow, R | 1 |
| Kramnik, I | 1 |
| Nuermberger, EL | 1 |
| Voskuil, MI | 1 |
| Lenaerts, AJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pharmacometrics to Advance Novel Regimens for Drug-resistant Tuberculosis[NCT03827811] | 625 participants (Anticipated) | Observational | 2020-01-30 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 other studies available for clofazimine and Necrosis
| Article | Year |
|---|---|
Do Anti-tuberculosis Drugs Reach Their Target?─High-Resolution Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging Provides Information on Drug Penetration into Necrotic Granulomas.
Topics: Animals; Antitubercular Agents; Clofazimine; Granuloma; Humans; Lasers; Mice; Mycobacterium tubercul | 2022 |
Limited activity of clofazimine as a single drug in a mouse model of tuberculosis exhibiting caseous necrotic granulomas.
Topics: Animals; Antitubercular Agents; Bacterial Load; Clofazimine; Disease Models, Animal; Female; Granulo | 2014 |