An interleukin-8 that is encoded in the genome of human. [PMID:15623624, SALO:AJ]
IL-8; This protein enables 5 target(s): This protein is located in 1 target(s): This protein is active in 1 target(s): This protein is involved in 27 target(s):
C-X-C motif chemokine 8;
Chemokine (C-X-C motif) ligand 8;
Emoctakin;
Granulocyte chemotactic protein 1;
GCP-1;
Monocyte-derived neutrophil chemotactic factor;
MDNCF;
Monocyte-derived neutrophil-activating peptide;Research
Bioassay Publications (1)
Timeframe Studies on this Protein(%) All Drugs % pre-1990 0 (0.00) 18.7374 1990's 0 (0.00) 18.2507 2000's 1 (100.00) 29.6817 2010's 0 (0.00) 24.3611 2020's 0 (0.00) 2.80 Compounds (7)
Drugs with Inhibition Measurements
Drug Taxonomy Measurement Average (mM) Bioassay(s) Publication(s) diclofenac Homo sapiens (human) IC50 0.0080 1 1 indomethacin Homo sapiens (human) IC50 0.0500 1 1 tolmetin Homo sapiens (human) IC50 0.0900 1 1 ibufenac Homo sapiens (human) IC50 1.0000 1 1 ibuprofen, (r)-isomer Homo sapiens (human) IC50 0.0500 1 1 ketoprofen Homo sapiens (human) IC50 0.0200 1 1 2-anilinophenylacetic acid Homo sapiens (human) IC50 1.0000 1 1 Enables
Target Category Definition interleukin-8 receptor binding molecular function Binding to an interleukin-8 receptor. [GOC:go_curators] protein binding molecular function Binding to a protein. [GOC:go_curators] chemokine activity molecular function The function of a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria. [GOC:BHF, GOC:rl, PMID:12183377, Wikipedia:Chemokine] heparin binding molecular function Binding to heparin, a member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues. [GOC:jl, ISBN:0198506732] CXCR chemokine receptor binding molecular function Binding to a chemokine receptor in the CXCR family. [GOC:ceb, PMID:11910892] Located In
Target Category Definition extracellular region cellular component The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators] Active In
Target Category Definition extracellular space cellular component That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684] Involved In
Target Category Definition angiogenesis biological process Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. [ISBN:0878932453] response to molecule of bacterial origin biological process Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of bacterial origin such as peptides derived from bacterial flagellin. [GOC:rl, GOC:sm] chemotaxis biological process The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). [ISBN:0198506732] inflammatory response biological process The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. [GO_REF:0000022, ISBN:0198506732] signal transduction biological process The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. [GOC:go_curators, GOC:mtg_signaling_feb11] G protein-coupled receptor signaling pathway biological process The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor] negative regulation of cell population proliferation biological process Any process that stops, prevents or reduces the rate or extent of cell proliferation. [GOC:go_curators] calcium-mediated signaling biological process Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions. [GOC:signaling] regulation of cell adhesion biological process Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix. [GOC:mah] neutrophil chemotaxis biological process The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding. [GOC:jl, ISBN:0198506732] receptor internalization biological process A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane. [GOC:bf, GOC:mah, GOC:signaling, PMID:15006537, PMID:19643732] response to endoplasmic reticulum stress biological process Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen. [GOC:cjm, GOC:mah] intracellular signal transduction biological process The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] neutrophil activation biological process The change in morphology and behavior of a neutrophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. [GOC:mgi_curators, ISBN:0781735149] cellular response to fibroblast growth factor stimulus biological process Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an fibroblast growth factor stimulus. [GOC:jl, GOC:yaf] regulation of single stranded viral RNA replication via double stranded DNA intermediate biological process Any process that modulates the frequency, rate or extent of single stranded viral RNA replication via double stranded DNA intermediate. [GOC:go_curators] negative regulation of G protein-coupled receptor signaling pathway biological process Any process that stops, prevents, or reduces the frequency, rate or extent of G protein-coupled receptor signaling pathway. [GOC:go_curators] positive regulation of angiogenesis biological process Any process that activates or increases angiogenesis. [GOC:go_curators] embryonic digestive tract development biological process The process whose specific outcome is the progression of the gut over time, from its formation to the mature structure during embryonic development. The gut is the region of the digestive tract extending from the beginning of the intestines to the anus. [GOC:go_curators] induction of positive chemotaxis biological process Any process that initiates the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical. [GOC:ai] cellular response to lipopolysaccharide biological process Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria. [GOC:mah] cellular response to interleukin-1 biological process Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus. [GOC:mah] cellular response to tumor necrosis factor biological process Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus. [GOC:mah] positive regulation of neutrophil chemotaxis biological process Any process that increases the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding. [GOC:dph, GOC:tb] regulation of entry of bacterium into host cell biological process Any process that modulates the frequency, rate or extent of entry of bacterium into host cell. [GOC:obol] antimicrobial humoral immune response mediated by antimicrobial peptide biological process An immune response against microbes mediated by anti-microbial peptides in body fluid. [PMID:15761415, PMID:24287494] chemokine-mediated signaling pathway biological process The series of molecular signals initiated by a chemokine binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:mah, GOC:signaling]