Protein-L-isoaspartate(D-aspartate) O-methyltransferase

A protein-L-isoaspartate(D-aspartate) O-methyltransferase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P22061]

Synonyms

PIMT;
EC 2.1.1.77;
L-isoaspartyl protein carboxyl methyltransferase;
Protein L-isoaspartyl/D-aspartyl methyltransferase;
Protein-beta-aspartate methyltransferase

Research

Bioassay Publications (1)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	1 (100.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Compounds (2)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
s-adenosylmethionine	Homo sapiens (human)	Ki	106.0000	2	2
sinefungin	Homo sapiens (human)	Ki	86.5000	2	2

Enables

This protein enables 3 target(s):

Target	Category	Definition
protein-L-isoaspartate (D-aspartate) O-methyltransferase activity	molecular function	Catalysis of the reaction: S-adenosyl-L-methionine + protein L-beta-aspartate = S-adenosyl-L-homocysteine + protein L-beta-aspartate methyl ester. [EC:2.1.1.77]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
cadherin binding	molecular function	Binding to cadherin, a type I membrane protein involved in cell adhesion. [GOC:bf]

Located In

This protein is located in 3 target(s):

Target	Category	Definition
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
extracellular exosome	cellular component	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]
extracellular vesicle	cellular component	Any vesicle that is part of the extracellular region. [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]

Involved In

This protein is involved in 2 target(s):

Target	Category	Definition
protein methylation	biological process	The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom. [GOC:ai]
protein repair	biological process	The process of restoring a protein to its original state after damage by such things as oxidation or spontaneous decomposition of residues. [GOC:mlg]