Proteins > Metallo-beta-lactamase type 2
Page last updated: 2024-08-07 19:54:36
Metallo-beta-lactamase type 2
A protein that is a translation product of any of the plasmid-encoded copies of the blaNDM-1 gene in Klebsiella pneumoniae. [PRO:DNx, UniProtKB:C7C422]
Synonyms
EC 3.5.2.6;
B2 metallo-beta-lactamase;
Beta-lactamase type II;
Metallo-beta-lactamase NDM-1;
Metallo-beta-lactamase type II;
New Delhi metallo-beta-lactamase-1;
NDM-1
Research
Bioassay Publications (2)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (13)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| indolebutyric acid | Klebsiella pneumoniae | IC50 | 1,947.9200 | 1 | 2 |
| captopril | Klebsiella pneumoniae | IC50 | 49.9594 | 1 | 2 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| indolebutyric acid | Klebsiella pneumoniae | Kd | 800.1640 | 1 | 2 |
| captopril | Klebsiella pneumoniae | Kd | 14.0627 | 1 | 2 |
| meropenem | Klebsiella pneumoniae | Kd | 11.0000 | 1 | 1 |
Drugs with Other Measurements
Fragment-based discovery of inhibitor scaffolds targeting the metallo-β-lactamases NDM-1 and VIM-2.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 26, Issue:8, 2016
Characterization of a new metallo-beta-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India.Antimicrobial agents and chemotherapy, , Volume: 53, Issue:12, 2009