Compounds > cl 277082
Page last updated: 2024-11-07

cl 277082

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

CL 277082: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID125893
CHEMBL ID277986
SCHEMBL ID408973
MeSH IDM0144138

Synonyms (19)

Synonym
cl-277082
ddpmhu
CHEMBL277986 ,
3-(2,4-difluorophenyl)-1-[[4-(2,2-dimethylpropyl)phenyl]methyl]-1-heptylurea
3-(2,4-difluorophenyl)-1-[4-(2,2-dimethylpropyl)benzyl]-1-heptylurea
96224-26-9
bdbm50022279
3-(2,4-difluoro-phenyl)-1-[4-(2,2-dimethyl-propyl)-benzyl]-1-heptyl-urea
kof50ra8pq ,
n'-(2,4-difluororphenyl)-n-((4-(2,2-dimethylpropyl)phenyl)methyl)-n-heptylurea
urea, n'-(2,4-difluorophenyl)-n-((4-(2,2-dimethylpropyl)phenyl)methyl)-n-heptyl-
unii-kof50ra8pq
cl 277082
SCHEMBL408973
n'-(2,4-difluorophenyl)-n-heptyl-n-(4-neopentylbenzyl)urea
n'-(2,4-difluorophenyl)-n-((4-(2,2-dimethylpropyl)phenyl)methyl)-n-heptylurea
n'-(2,4-difluorophenyl)-n-{[4-(2,2-dimethylpropyl)phenyl]methyl}-n-heptylcarbamimidic acid
DTXSID70914605
AKOS040751209

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
" This compound displayed excellent in vitro efficacy, irrespective of dosing method, indicating superior characteristics compared to other ACAT inhibitors."( Synthesis, X-ray crystal structure, and biological activity of FR186054, a novel, potent, orally active inhibitor of acyl-CoA:cholesterol O-acyltransferase (ACAT) bearing a pyrazole ring.
Hagihara, H; Ishibe, N; Kinoshita, T; Sakuma, Y; Sawada, M; Takasugi, H; Tanaka, A; Tanaka, H; Terasawa, T, 1998)		0.3
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (2)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Sterol O-acyltransferase 1Homo sapiens (human)IC50 (µMol)0.68000.02501.79758.0000AID126499; AID31809; AID92022
Acyl-CoA:cholesterol acyltransferase Oryctolagus cuniculus (rabbit)IC50 (µMol)0.14330.00600.98467.6000AID31204; AID31205; AID31218
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (8)

Processvia Protein(s)Taxonomy
cholesterol metabolic processSterol O-acyltransferase 1Homo sapiens (human)
cholesterol metabolic processSterol O-acyltransferase 1Homo sapiens (human)
macrophage derived foam cell differentiationSterol O-acyltransferase 1Homo sapiens (human)
cholesterol storageSterol O-acyltransferase 1Homo sapiens (human)
cholesterol effluxSterol O-acyltransferase 1Homo sapiens (human)
very-low-density lipoprotein particle assemblySterol O-acyltransferase 1Homo sapiens (human)
low-density lipoprotein particle clearanceSterol O-acyltransferase 1Homo sapiens (human)
cholesterol homeostasisSterol O-acyltransferase 1Homo sapiens (human)
positive regulation of amyloid precursor protein biosynthetic processSterol O-acyltransferase 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (5)

Processvia Protein(s)Taxonomy
fatty-acyl-CoA bindingSterol O-acyltransferase 1Homo sapiens (human)
sterol O-acyltransferase activitySterol O-acyltransferase 1Homo sapiens (human)
protein bindingSterol O-acyltransferase 1Homo sapiens (human)
cholesterol bindingSterol O-acyltransferase 1Homo sapiens (human)
cholesterol O-acyltransferase activitySterol O-acyltransferase 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (3)

Processvia Protein(s)Taxonomy
endoplasmic reticulumSterol O-acyltransferase 1Homo sapiens (human)
endoplasmic reticulum membraneSterol O-acyltransferase 1Homo sapiens (human)
membraneSterol O-acyltransferase 1Homo sapiens (human)
endoplasmic reticulum membraneSterol O-acyltransferase 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (39)

Assay IDTitleYearJournalArticle
AID125519Effect the compound on Cholesterol O-Acyltransferase (ACAT)-catalyzed cholesteryl oleate formation (COF) in cultured monkey arterial smooth muscle cells in experiment 2 in the presence of Cationized Low-density lipoproteins +1 uM1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Potential antiatherosclerotic agents. 5. An acyl-CoA:cholesterol O-acyltransferase inhibitor with hypocholesterolemic activity.
AID191837Compound was evaluated for the effect of serum lipids in cholesterol-fed rats Serum triglyceride at a dose of 10 mg/kg per day1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Potential antiatherosclerotic agents. 5. An acyl-CoA:cholesterol O-acyltransferase inhibitor with hypocholesterolemic activity.
AID176593Hypocholesterolemic activity to reduce plasma total cholesterol level by 50% after dietary administration in cholesterol-fed rats1998Bioorganic & medicinal chemistry letters, Jan-06, Volume: 8, Issue:1
Synthesis, X-ray crystal structure, and biological activity of FR186054, a novel, potent, orally active inhibitor of acyl-CoA:cholesterol O-acyltransferase (ACAT) bearing a pyrazole ring.
AID125517Effect on Cholesterol O-Acyltransferase (ACAT)-catalyzed cholesteryl oleate formation (COF) in cultured monkey arterial smooth muscle cells Cationized-LDL1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Potential antiatherosclerotic agents. 5. An acyl-CoA:cholesterol O-acyltransferase inhibitor with hypocholesterolemic activity.
AID178588Effective dose to reduce plasma total cholesterol level by 50% of the control value in cholesterol fed rats1998Journal of medicinal chemistry, Jun-18, Volume: 41, Issue:13
Inhibitors of acyl-CoA:cholesterol O-acyltransferase. 2. Identification and structure-activity relationships of a novel series of N-alkyl-N-(heteroaryl-substituted benzyl)-N'-arylureas.
AID185873Effect of liver Cholesterol absorption in cholesterol-fed rats1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Potential antiatherosclerotic agents. 5. An acyl-CoA:cholesterol O-acyltransferase inhibitor with hypocholesterolemic activity.
AID31202Inhibition against acyl coenzyme A:cholesterol acyltransferase derived from rabbit aorta homogenate1993Journal of medicinal chemistry, May-28, Volume: 36, Issue:11
Structure-activity relationship of a series of phenylureas linked to 4-phenylimidazole. Novel potent inhibitors of acyl-CoA:cholesterol O-acyltransferase with antiatherosclerotic activity. 2.
AID92022Compound was evaluated for the effect on Cholesterol O-Acyltransferase (ACAT) in intestinal microsomes1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Potential antiatherosclerotic agents. 5. An acyl-CoA:cholesterol O-acyltransferase inhibitor with hypocholesterolemic activity.
AID177206Tested for hypocholesterolemic activity required to decrease serum total cholesterol1993Journal of medicinal chemistry, May-28, Volume: 36, Issue:11
Structure-activity relationship of a series of phenylureas linked to 4-phenylimidazole. Novel potent inhibitors of acyl-CoA:cholesterol O-acyltransferase with antiatherosclerotic activity. 2.
AID31063In vitro inhibitory activity against acyl coenzyme A:cholesterol acyltransferase in liver microsomes isolated from cholesterol-fed rabbits1994Journal of medicinal chemistry, Mar-18, Volume: 37, Issue:6
Inhibitors of acyl-CoA:cholesterol acyltransferase. 1. Synthesis and hypocholesterolemic activity of dibenz[b,e]oxepin-11-carboxanilides.
AID38740Effect on Cholesterol O-Acyltransferase (ACAT)-catalyzed cholesteryl oleate formation (COF) in cultured monkey arterial smooth muscle (LDL)+0.1 uM1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Potential antiatherosclerotic agents. 5. An acyl-CoA:cholesterol O-acyltransferase inhibitor with hypocholesterolemic activity.
AID84848In vivo dose effecting the cholesteryl esters in cholesterol-fed hamsters at a dose of 50(mpk)1995Journal of medicinal chemistry, May-12, Volume: 38, Issue:10
Substituted (1,2-diarylethyl)amide acyl-CoA:cholesterol acyltransferase inhibitors: effect of polar groups on in vitro and in vivo activity.
AID172939Effect of serum lipids in cholesterol-fed rats and Serum cholesterol at a dose of 1 mg/kg per day of the compound.1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Potential antiatherosclerotic agents. 5. An acyl-CoA:cholesterol O-acyltransferase inhibitor with hypocholesterolemic activity.
AID87101In vivo hypocholesterolemic activity in golden hamsters, fed with a diet containing 2% cholesterol at a dose of 10 mg/kg, po1994Journal of medicinal chemistry, Mar-18, Volume: 37, Issue:6
Inhibitors of acyl-CoA:cholesterol acyltransferase. 1. Synthesis and hypocholesterolemic activity of dibenz[b,e]oxepin-11-carboxanilides.
AID31065In vitro inhibitory activity towards ACAT by the displacement of [1-14C]oleolyl-CoA from the small intestine of cholesterol-fed rabbits1998Bioorganic & medicinal chemistry letters, Jan-06, Volume: 8, Issue:1
Synthesis, X-ray crystal structure, and biological activity of FR186054, a novel, potent, orally active inhibitor of acyl-CoA:cholesterol O-acyltransferase (ACAT) bearing a pyrazole ring.
AID191839Effect of serum lipids in cholesterol-fed rats Serum triglyceride at a dose of 1 mg/kg per day of the compound.1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Potential antiatherosclerotic agents. 5. An acyl-CoA:cholesterol O-acyltransferase inhibitor with hypocholesterolemic activity.
AID31664In vitro inhibition of acyl coenzyme A:cholesterol acyltransferase 1, rat liver microsomal assay1995Journal of medicinal chemistry, May-12, Volume: 38, Issue:10
Substituted (1,2-diarylethyl)amide acyl-CoA:cholesterol acyltransferase inhibitors: effect of polar groups on in vitro and in vivo activity.
AID185874Effect of liver Cholesterol absorption in cholesterol-fed rats1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Potential antiatherosclerotic agents. 5. An acyl-CoA:cholesterol O-acyltransferase inhibitor with hypocholesterolemic activity.
AID84307In vivo effect on cholesteryl esters in cholesterol-fed hamsters at a dose of 50(mpk)1995Journal of medicinal chemistry, May-12, Volume: 38, Issue:10
Substituted (1,2-diarylethyl)amide acyl-CoA:cholesterol acyltransferase inhibitors: effect of polar groups on in vitro and in vivo activity.
AID126499Inhibition of smooth muscle cell ACAT activity for cells stimulated by cationized LDL.1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Potential antiatherosclerotic agents. 5. An acyl-CoA:cholesterol O-acyltransferase inhibitor with hypocholesterolemic activity.
AID191838Effect of serum lipids in cholesterol-fed rats Serum triglyceride at a dose of 1 mg/kg per day of the compound.1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Potential antiatherosclerotic agents. 5. An acyl-CoA:cholesterol O-acyltransferase inhibitor with hypocholesterolemic activity.
AID31218In vitro inhibitory activity against Acyl coenzyme A:cholesterol acyltransferase (ACAT) in rabbit intestinal microsomes1998Journal of medicinal chemistry, Jun-18, Volume: 41, Issue:13
Inhibitors of acyl-CoA:cholesterol O-acyltransferase. 2. Identification and structure-activity relationships of a novel series of N-alkyl-N-(heteroaryl-substituted benzyl)-N'-arylureas.
AID31810Compound was evaluated for the effect on Cholesterol O-Acyltransferase (ACAT) in Liver microsomes1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Potential antiatherosclerotic agents. 5. An acyl-CoA:cholesterol O-acyltransferase inhibitor with hypocholesterolemic activity.
AID31685Effect on Cholesterol O-Acyltransferase (ACAT)-catalyzed cholesteryl oleate formation (COF) in cultured monkey arterial smooth muscle cells in the presence of Cationized Low-density lipoproteins + 0.3 uM1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Potential antiatherosclerotic agents. 5. An acyl-CoA:cholesterol O-acyltransferase inhibitor with hypocholesterolemic activity.
AID31809Inhibition of smooth muscle cell ACAT activity for cells stimulated by native LDL.1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Potential antiatherosclerotic agents. 5. An acyl-CoA:cholesterol O-acyltransferase inhibitor with hypocholesterolemic activity.
AID176592Hypocholesterolemic activity by administration of gavage in PEG400 as a vehicle in cholesterol-fed rats; ND not determined1998Bioorganic & medicinal chemistry letters, Jan-06, Volume: 8, Issue:1
Synthesis, X-ray crystal structure, and biological activity of FR186054, a novel, potent, orally active inhibitor of acyl-CoA:cholesterol O-acyltransferase (ACAT) bearing a pyrazole ring.
AID84311In vivo effect on serum cholesterol level of cholesterol-fed hamsters at a dose of 50(mpk)1995Journal of medicinal chemistry, May-12, Volume: 38, Issue:10
Substituted (1,2-diarylethyl)amide acyl-CoA:cholesterol acyltransferase inhibitors: effect of polar groups on in vitro and in vivo activity.
AID177673Effective concentration required to effect liver cholesterol concentrations in rat1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Potential antiatherosclerotic agents. 5. An acyl-CoA:cholesterol O-acyltransferase inhibitor with hypocholesterolemic activity.
AID31205Inhibition against acyl coenzyme A:cholesterol acyltransferase derived from rabbit intestine microsomes1993Journal of medicinal chemistry, May-28, Volume: 36, Issue:11
Structure-activity relationship of a series of phenylureas linked to 4-phenylimidazole. Novel potent inhibitors of acyl-CoA:cholesterol O-acyltransferase with antiatherosclerotic activity. 2.
AID31070Tested for inhibition against acyl coenzyme A:cholesterol acyltransferase from rabbit aorta homogenate.1993Journal of medicinal chemistry, May-28, Volume: 36, Issue:11
Structure-activity relationship of N-[2-(dimethylamino)-6-[3-(5-methyl-4-phenyl-1H-imidazol-1-yl)propoxy] phenyl]-N'-pentylurea and analogues. Novel potent inhibitors of acyl-CoA:cholesterol O-acyltransferase with antiatherosclerotic activity.
AID172938Compound was evaluated for the effect on serum lipids in cholesterol-fed rats1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Potential antiatherosclerotic agents. 5. An acyl-CoA:cholesterol O-acyltransferase inhibitor with hypocholesterolemic activity.
AID101862Compound was evaluated for the effect on Cholesterol O-Acyltransferase (ACAT) in Aorta (homogenate Low-density lipoproteins (LDL)1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Potential antiatherosclerotic agents. 5. An acyl-CoA:cholesterol O-acyltransferase inhibitor with hypocholesterolemic activity.
AID87102In vivo hypocholesterolemic activity in golden hamsters, fed with a diet containing 2% cholesterol at a dose of 30 mg/kg, po1994Journal of medicinal chemistry, Mar-18, Volume: 37, Issue:6
Inhibitors of acyl-CoA:cholesterol acyltransferase. 1. Synthesis and hypocholesterolemic activity of dibenz[b,e]oxepin-11-carboxanilides.
AID31204Tested for inhibition against acyl coenzyme A:cholesterol acyltransferase from rabbit intestine microsomes.1993Journal of medicinal chemistry, May-28, Volume: 36, Issue:11
Structure-activity relationship of N-[2-(dimethylamino)-6-[3-(5-methyl-4-phenyl-1H-imidazol-1-yl)propoxy] phenyl]-N'-pentylurea and analogues. Novel potent inhibitors of acyl-CoA:cholesterol O-acyltransferase with antiatherosclerotic activity.
AID31683Effect on Cholesterol O-Acyltransferase (ACAT)-catalyzed cholesteryl oleate formation (COF) in cultured monkey arterial smooth muscle cells1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Potential antiatherosclerotic agents. 5. An acyl-CoA:cholesterol O-acyltransferase inhibitor with hypocholesterolemic activity.
AID31684Effect on Cholesterol O-Acyltransferase (ACAT)-catalyzed cholesteryl oleate formation (COF) in cultured monkey arterial smooth muscle cells (LDL)+1 uM1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Potential antiatherosclerotic agents. 5. An acyl-CoA:cholesterol O-acyltransferase inhibitor with hypocholesterolemic activity.
AID125518Effect on Cholesterol O-Acyltransferase (ACAT)-catalyzed cholesteryl oleate formation (COF) in cultured monkey arterial smooth muscle cells in experiment 2 in the presence ofCationized Low-density lipoproteins +10 uM1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Potential antiatherosclerotic agents. 5. An acyl-CoA:cholesterol O-acyltransferase inhibitor with hypocholesterolemic activity.
AID125516Effect on Cholesterol O-Acyltransferase (ACAT)-catalyzed cholesteryl oleate formation (COF) in cultured monkey arterial smooth muscle cells (LDL)+10 uM1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Potential antiatherosclerotic agents. 5. An acyl-CoA:cholesterol O-acyltransferase inhibitor with hypocholesterolemic activity.
AID31808Effect on Cholesterol O-Acyltransferase (ACAT)-catalyzed cholesteryl oleate formation (COF) in cultured monkey arterial smooth muscle cells in experiment 2 in the presence ofCationized Low-density lipoproteins +3 uM1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Potential antiatherosclerotic agents. 5. An acyl-CoA:cholesterol O-acyltransferase inhibitor with hypocholesterolemic activity.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (25)

TimeframeStudies, This Drug (%)All Drugs %
pre-19903 (12.00)18.7374
1990's21 (84.00)18.2507
2000's1 (4.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.75

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.75 (24.57)
Research Supply Index3.30 (2.92)
Research Growth Index5.05 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.75)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (4.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other24 (96.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
carbamates
[no description available]		1.9810amino-acid anion
urea
pseudourea: clinical use; structure. isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.		2.3920isourea;
monocarboxylic acid amide;
one-carbon compound		Daphnia magna metabolite;
Escherichia coli metabolite;
fertilizer;
flour treatment agent;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
clofibrate
angiokapsul: contains clofibrate & insoitolnicotinate		1.9910aromatic ether;
ethyl ester;
monochlorobenzenes		anticholesteremic drug;
antilipemic drug;
geroprotector;
PPARalpha agonist
probucol
Probucol: A drug used to lower LDL and HDL cholesterol yet has little effect on serum-triglyceride or VLDL cholesterol. (From Martindale, The Extra Pharmacopoeia, 30th ed, p993).. probucol : A dithioketal that is propane-2,2-dithiol in which the hydrogens attached to both sulfur atoms are replaced by 3,5-di-tert-butyl-4-hydroxyphenyl groups. An anticholesteremic drug with antioxidant and anti-inflammatory properties, it is used to treat high levels of cholesterol in blood.		1.9910dithioketal;
polyphenol		anti-inflammatory drug;
anticholesteremic drug;
antilipemic drug;
antioxidant;
cardiovascular drug
methionine
Methionine: A sulfur-containing essential L-amino acid that is important in many body functions.. methionine : A sulfur-containing amino acid that is butyric acid bearing an amino substituent at position 2 and a methylthio substituent at position 4.		2.0110aspartate family amino acid;
L-alpha-amino acid;
methionine zwitterion;
methionine;
proteinogenic amino acid		antidote to paracetamol poisoning;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical
pyrroles
1H-pyrrole : A tautomer of pyrrole that has the double bonds at positions 2 and 4.. pyrrole : A five-membered monocyclic heteroarene comprising one NH and four CH units which forms the parent compound of the pyrrole group of compounds. Its five-membered ring structure has three tautomers. A 'closed class'.. azole : Any monocyclic heteroarene consisting of a five-membered ring containing nitrogen. Azoles can also contain one or more other non-carbon atoms, such as nitrogen, sulfur or oxygen.		2.420pyrrole;
secondary amine
tetradecanoylphorbol acetate
Tetradecanoylphorbol Acetate: A phorbol ester found in CROTON OIL with very effective tumor promoting activity. It stimulates the synthesis of both DNA and RNA.. phorbol ester : Esters of phorbol, originally found in croton oil (from Croton tiglium, of the family Euphorbiaceae). A number of phorbol esters possess activity as tumour promoters and activate the mechanisms associated with cell growth. Some of these are used in experiments as activators of protein kinase C.. phorbol 13-acetate 12-myristate : A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types.		1.9810acetate ester;
diester;
phorbol ester;
tertiary alpha-hydroxy ketone;
tetradecanoate ester		antineoplastic agent;
apoptosis inducer;
carcinogenic agent;
mitogen;
plant metabolite;
protein kinase C agonist;
reactive oxygen species generator
phenyl acetate
phenyl acetate: The ester formed between phenol and acetic acid. Don't confuse with phenylacetic acid derivatives listed under PHENYLACETATES.. phenyl acetate : An acetate ester obtained by the formal condensation of phenol with acetic acid.		1.9810benzenes;
phenyl acetates
bezafibrate
[no description available]		1.9910aromatic ether;
monocarboxylic acid amide;
monocarboxylic acid;
monochlorobenzenes		antilipemic drug;
environmental contaminant;
geroprotector;
xenobiotic
simvastatin
Simvastatin: A derivative of LOVASTATIN and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic LDL RECEPTORS, it increases breakdown of LDL CHOLESTEROL.. simvastatin : A member of the class of hexahydronaphthalenes that is lovastatin in which the 2-methylbutyrate ester moiety has been replaced by a 2,2-dimethylbutyrate ester group. It is used as a cholesterol-lowering and anti-cardiovascular disease drug.		1.9910delta-lactone;
fatty acid ester;
hexahydronaphthalenes;
statin (semi-synthetic)		EC 1.1.1.34/EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitor;
EC 3.4.24.83 (anthrax lethal factor endopeptidase) inhibitor;
ferroptosis inducer;
geroprotector;
prodrug
pravastatin
Pravastatin: An antilipemic fungal metabolite isolated from cultures of Nocardia autotrophica. It acts as a competitive inhibitor of HMG CoA reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES).. pravastatin : A carboxylic ester resulting from the formal condensation of (S)-2-methylbutyric acid with the hydroxy group adjacent to the ring junction of (3R,5R)-7-[(1S,2S,6S,8S,8aR)-6,8-dihydroxy-2-methyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid. Derived from microbial transformation of mevastatin, pravastatin is a reversible inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA). The sodium salt is used for lowering cholesterol and preventing cardiovascular disease. It is one of the lower potency statins, but has the advantage of fewer side effects compared with lovastatin and simvastatin.		1.99103-hydroxy carboxylic acid;
carbobicyclic compound;
carboxylic ester;
hydroxy monocarboxylic acid;
secondary alcohol;
statin (semi-synthetic)		anticholesteremic drug;
environmental contaminant;
metabolite;
xenobiotic
atorvastatin
[no description available]		2.0110aromatic amide;
dihydroxy monocarboxylic acid;
monofluorobenzenes;
pyrroles;
statin (synthetic)		environmental contaminant;
xenobiotic
25-hydroxycholesterol
[no description available]		2.42025-hydroxy steroid;
oxysterol		human metabolite
octimibate
[no description available]		1.9810
lecimibide
[no description available]		2.3920
7-hydroxystaurosporine
[no description available]		1.9810
san 58035
[no description available]		1.9810
pd 128042
PD 128042: structure given in first source		2.6830anilide
n-(2,6-bis(1-methylethyl)phenyl)-n'-((1-(4-(dimethylamino)phenyl)cyclopentyl)methyl)urea hydrochloride
N-(2,6-bis(1-methylethyl)phenyl)-N'-((1-(4-(dimethylamino)phenyl)cyclopentyl)methyl)urea hydrochloride: structure given in first source; a lipid regulator		1.9810
e 5324
E 5324: structure given in first source		1.9810
cp 113818
CP 113818: structure in first source		1.9910
f 1394
F 1394: an acyl-CoA:cholesterol acyltransferase (ACAT) inibitor; structure given in first source		1.9910
ym17e
YM17E: structure given in first source		1.9810
mevalonic acid
Mevalonic Acid: A dihydroxy monocarboxylic acid and precursor in the biosynthetic pathway known as the mevalonate pathway, which produces terpenes and steroids that are vital for diverse cellular functions.. mevalonic acid : A racemate composed of equimolar amounts of (R)- and (S)-mevalonic acid.. (R)-mevalonic acid : The (R)-enantiomer of mevalonic acid.		1.99103,5-dihydroxy-3-methylpentanoic acid
oleic acid
Oleic Acid: An unsaturated fatty acid that is the most widely distributed and abundant fatty acid in nature. It is used commercially in the preparation of oleates and lotions, and as a pharmaceutical solvent. (Stedman, 26th ed). oleic acid : An octadec-9-enoic acid in which the double bond at C-9 has Z (cis) stereochemistry.		2.6830octadec-9-enoic acidantioxidant;
Daphnia galeata metabolite;
EC 3.1.1.1 (carboxylesterase) inhibitor;
Escherichia coli metabolite;
mouse metabolite;
plant metabolite;
solvent
phorbol-12,13-didecanoate
phorbol-12,13-didecanoate: RN given refers to (1aR-(1a alpha,1b beta,4a beta,7a alpha,7b alpha,8 alpha,9 beta,9a alpha))-isomer		1.9810
kt 5720
KT 5720: indolocarbazole; synthetic derivative of K 252a. KT 5720 : An organic heterooctacyclic compound that is 1H,1'H-2,2'-biindole in which the nitrogens have undergone formal oxidative coupling to positions 2 and 5 of hexyl (3S)-3-hydroxy-2-methyltetrahydrofuran-3-carboxylate (the 2R,3S,5S product), and in which the 3 and 3' positions of the biindole moiety have also undergone formal oxidative coupling to positions 3 and 4 of 1,5-dihydro-2H-pyrrol-2-one.		1.9810carboxylic ester;
gamma-lactam;
hemiaminal;
indolocarbazole;
organic heterooctacyclic compound;
semisynthetic derivative;
tertiary alcohol		EC 2.7.11.11 (cAMP-dependent protein kinase) inhibitor
((2,6-bis(1-methylethyl)phenoxy)sulfonyl)carbamic acid 2,6-bis(1-methylethyl)phenyl ester
((2,6-bis(1-methylethyl)phenoxy)sulfonyl)carbamic acid 2,6-bis(1-methylethyl)phenyl ester: a water soluble inhibitor of ACAT; structure in first source		1.9810
lr 16
LR 16: structure given in first source; has potent effects on oxygen affinity of hemoglobin, on blood cholesterol and on low density lipoprotein		1.9910
staurosporine
staurosporinium : Conjugate acid of staurosporine.		1.9810ammonium ion derivative
pd 138142-15
[no description available]		1.9910
phosphatidylcholines
Phosphatidylcholines: Derivatives of PHOSPHATIDIC ACIDS in which the phosphoric acid is bound in ester linkage to a CHOLINE moiety.		2.39201,2-diacyl-sn-glycero-3-phosphocholine
cholestyramine resin
Cholestyramine Resin: A strongly basic anion exchange resin whose main constituent is polystyrene trimethylbenzylammonium Cl(-) anion.		1.9810
filipin
Filipin: A complex of polyene antibiotics obtained from Streptomyces filipinensis. Filipin III alters membrane function by interfering with membrane sterols, inhibits mitochondrial respiration, and is proposed as an antifungal agent. Filipins I, II, and IV are less important.		1.9810
ConditionIndicatedRelationship StrengthStudiesTrials
Arteriosclerosis
Thickening and loss of elasticity of the walls of ARTERIES of all sizes. There are many forms classified by the types of lesions and arteries involved, such as ATHEROSCLEROSIS with fatty lesions in the ARTERIAL INTIMA of medium and large muscular arteries.		02.6730
Necrosis
The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.		01.9910
Elevated Cholesterol
[description not available]		01.9810
Hypercholesterolemia
A condition with abnormally high levels of CHOLESTEROL in the blood. It is defined as a cholesterol value exceeding the 95th percentile for the population.		01.9810
Alloxan Diabetes
[description not available]		02.3820
Body Weight
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.		01.9810
Granulomas
[description not available]		06.9710
Granuloma
A relatively small nodular inflammatory lesion containing grouped mononuclear phagocytes, caused by infectious and noninfectious agents.		06.9710