Proteins > Oxysterols receptor LXR-alpha
Page last updated: 2024-08-07 17:04:40

Oxysterols receptor LXR-alpha

An oxysterols receptor LXR-alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13133]

Synonyms

Liver X receptor alpha;
Nuclear receptor subfamily 1 group H member 3

Research

Bioassay Publications (61)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's21 (34.43)29.6817
2010's36 (59.02)24.3611
2020's4 (6.56)2.80

Compounds (30)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
1-deoxynojirimycinHomo sapiens (human)IC50137.500034
podocarpic acidHomo sapiens (human)IC5050.000011
22s-hydroxycholesterolHomo sapiens (human)Ki0.180011
gw 3965Homo sapiens (human)IC500.5691810
t0901317Homo sapiens (human)IC506.54022123
t0901317Homo sapiens (human)Ki0.095033
genisteinHomo sapiens (human)IC5046.000034
pregna-4,17-diene-3,16-dioneHomo sapiens (human)IC50100.000011
3-chloro-4-(3-(7-propyl-3-trifluoromethyl-6-benzisoxazolyl)propylthio)phenylacetic acidHomo sapiens (human)IC500.033722
riccardin cHomo sapiens (human)IC506.575034
way 252623Homo sapiens (human)IC500.127323
gsk4112Homo sapiens (human)IC505.000011
sr9009Homo sapiens (human)IC506.300011
sr9011Homo sapiens (human)IC5013.000011
sr9238Homo sapiens (human)IC500.187022

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
betulinic acidHomo sapiens (human)EC5050.000011
25-hydroxycholesterolHomo sapiens (human)EC501.160022
bexaroteneHomo sapiens (human)EC500.196011
3 beta-hydroxy-delta 5-cholenic acidHomo sapiens (human)EC503.000022
podocarpic acidHomo sapiens (human)EC5050.000022
(20s)-20-hydroxycholesterolHomo sapiens (human)EC500.470022
24-hydroxycholesterolHomo sapiens (human)EC500.130022
27-hydroxycholesterolHomo sapiens (human)EC500.250022
cyanidinHomo sapiens (human)EC503.500011
cyanidinHomo sapiens (human)Kd2.200011
(22r)-22-hydroxycholesterolHomo sapiens (human)EC506.393366
gw 3965Homo sapiens (human)EC500.32282326
gw 3965Homo sapiens (human)Kd6.970011
t0901317Homo sapiens (human)EC500.20134446
t0901317Homo sapiens (human)Kd0.092411
alitretinoinHomo sapiens (human)EC501.090011
24,25-epoxycholesterolHomo sapiens (human)EC502.778699
piericidin aHomo sapiens (human)Kd3.240011
pregna-4,17-diene-3,16-dioneHomo sapiens (human)EC50100.000011
acanthoic acidHomo sapiens (human)EC500.180011
3-chloro-4-(3-(7-propyl-3-trifluoromethyl-6-benzisoxazolyl)propylthio)phenylacetic acidHomo sapiens (human)EC501.559245
bms 687453Homo sapiens (human)EC5025.000011
way 252623Homo sapiens (human)EC503.690144
cholenic acid dimethylamideHomo sapiens (human)EC500.254033
glucopiericidin aHomo sapiens (human)Kd3,492,000.000011

Drugs with Other Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
betulinic acidHomo sapiens (human)LC5025.000011
podocarpic acidHomo sapiens (human)LC5050.000011
acanthoic acidHomo sapiens (human)LC500.250011
3-chloro-4-(3-(7-propyl-3-trifluoromethyl-6-benzisoxazolyl)propylthio)phenylacetic acidHomo sapiens (human)LC500.035011

Enables

This protein enables 11 target(s):

TargetCategoryDefinition
transcription cis-regulatory region bindingmolecular functionBinding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. [GOC:txnOH]
DNA-binding transcription factor activity, RNA polymerase II-specificmolecular functionA DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. [GOC:txnOH-2018]
DNA-binding transcription activator activity, RNA polymerase II-specificmolecular functionA DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II. [GOC:aruk, GOC:txnOH-2018, PMID:20737563, PMID:27145859]
DNA bindingmolecular functionAny molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
nuclear receptor activitymolecular functionA DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytosol, which leads to its translocation to the nucleus. [GOC:txnOH-2018, PMID:23457262]
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
zinc ion bindingmolecular functionBinding to a zinc ion (Zn). [GOC:ai]
cholesterol bindingmolecular functionBinding to cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. [GOC:jl, ISBN:0198506732]
chromatin DNA bindingmolecular functionBinding to DNA that is assembled into chromatin. [GOC:mah]
sterol response element bindingmolecular functionBinding to a sterol response element (SRE), a nonpalindromic sequence found in the promoters of genes involved in lipid metabolism. [GOC:vk, PMID:11994399]
RNA polymerase II cis-regulatory region sequence-specific DNA bindingmolecular functionBinding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. [GOC:txnOH-2018]

Located In

This protein is located in 4 target(s):

TargetCategoryDefinition
nucleuscellular componentA membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
nucleoplasmcellular componentThat part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
cytoplasmcellular componentThe contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
cytosolcellular componentThe part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

Active In

This protein is active in 1 target(s):

TargetCategoryDefinition
nucleuscellular componentA membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]

Part Of

This protein is part of 3 target(s):

TargetCategoryDefinition
RNA polymerase II transcription regulator complexcellular componentA transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II. [GOC:tb]
chromatincellular componentThe ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. [GOC:elh, PMID:20404130]
receptor complexcellular componentAny protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. [GOC:go_curators]

Involved In

This protein is involved in 37 target(s):

TargetCategoryDefinition
negative regulation of transcription by RNA polymerase IIbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH]
hormone-mediated signaling pathwaybiological processThe series of molecular signals mediated by the detection of a hormone. [GOC:sm]
negative regulation of macrophage derived foam cell differentiationbiological processAny process that decreases the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions. [GOC:add, GOC:BHF, GOC:dph, GOC:tb]
positive regulation of triglyceride biosynthetic processbiological processAny process that increases the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol. [GOC:BHF, GOC:tb]
positive regulation of cholesterol effluxbiological processAny process that increases the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle. [GOC:BHF, GOC:dph, GOC:tb]
negative regulation of cholesterol storagebiological processAny process that decreases the rate or extent of cholesterol storage. Cholesterol storage is the accumulation and maintenance in cells or tissues of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. [GOC:BHF, GOC:dph, GOC:tb]
intracellular receptor signaling pathwaybiological processThe series of molecular signals initiated by a ligand binding to a receptor located within a cell. [GOC:bf, GOC:mah]
negative regulation of lipid transportbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]
positive regulation of cholesterol transportbiological processAny process that activates or increases the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]
positive regulation of transporter activitybiological processAny process that activates or increases the activity of a transporter. [GOC:mah]
response to progesteronebiological processAny process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a progesterone stimulus. [GOC:sl]
positive regulation of toll-like receptor 4 signaling pathwaybiological processAny process that activates or increases the frequency, rate, or extent of toll-like receptor 4 signaling pathway. [GOC:add, PMID:16551253, PMID:17328678]
phosphatidylcholine acyl-chain remodelingbiological processRemodeling the acyl chains of phosphatidylcholine, through sequential deacylation and re-acylation reactions, to generate phosphatidylcholine containing different types of fatty acid acyl chains. [GOC:mw, PMID:18195019, PMID:18458083]
cholesterol homeostasisbiological processAny process involved in the maintenance of an internal steady state of cholesterol within an organism or cell. [GOC:go_curators]
regulation of circadian rhythmbiological processAny process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours. [GOC:dph, GOC:jl, GOC:tb]
mRNA transcription by RNA polymerase IIbiological processThe cellular synthesis of messenger RNA (mRNA) from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. [GOC:jl, ISBN:0321000382]
negative regulation of macrophage activationbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of macrophage activation. [GOC:jl]
apoptotic cell clearancebiological processThe recognition and removal of an apoptotic cell by a neighboring cell or by a phagocyte. [GOC:rk, PMID:14685684]
positive regulation of fatty acid biosynthetic processbiological processAny process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids. [GOC:go_curators]
negative regulation of proteolysisbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein. [GOC:go_curators]
positive regulation of DNA-templated transcriptionbiological processAny process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH]
positive regulation of transcription by RNA polymerase IIbiological processAny process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. [GOC:go_curators, GOC:txnOH]
positive regulation of lipid biosynthetic processbiological processAny process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids. [GOC:ai]
negative regulation of pinocytosisbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of pinocytosis. Pinocytosis is the process in which cells take in liquid material from their external environment; literally 'cell drinking'. Liquid is enclosed in vesicles, formed by invagination of the plasma membrane. These vesicles then move into the cell and pass their contents to endosomes. [GOC:go_curators]
negative regulation of inflammatory responsebiological processAny process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response. [GOC:ai]
positive regulation of lipoprotein lipase activitybiological processAny process that activates or increases the activity of the enzyme lipoprotein lipase. [GOC:ai]
positive regulation of protein metabolic processbiological processAny process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein. [GOC:ai]
lipid homeostasisbiological processAny process involved in the maintenance of an internal steady state of lipid within an organism or cell. [GOC:BHF, GOC:rl]
sterol homeostasisbiological processAny process involved in the maintenance of an internal steady state of sterol within an organism or cell. [GOC:BHF, GOC:rl]
negative regulation of type II interferon-mediated signaling pathwaybiological processAny process that decreases the rate, frequency or extent of an interferon-gamma-mediated signaling pathway. [GOC:dph]
triglyceride homeostasisbiological processAny process involved in the maintenance of an internal steady state of triglyceride within an organism or cell. [GOC:BHF, GOC:mah]
cellular response to lipopolysaccharidebiological processAny process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria. [GOC:mah]
negative regulation of pancreatic juice secretionbiological processAny process that decreases the rate, frequency or extent of pancreatic juice secretion, the regulated release of pancreatic juice by the exocrine pancreas into the upper part of the intestine. [GOC:BHF, GOC:dph, GOC:tb]
negative regulation of secretion of lysosomal enzymesbiological processAny process that decreases the rate, frequency or extent of secretion of lysosomal enzymes, the controlled release of lysosomal enzymes by a cell. [GOC:BHF]
negative regulation of cold-induced thermogenesisbiological processAny process that stops, prevents, or reduces the rate of cold-induced thermogenesis. [PMID:27876809]
negative regulation of response to endoplasmic reticulum stressbiological processAny process that stops, prevents or reduces the frequency, rate or extent of a response to endoplasmic reticulum stress. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:11381086]
cell differentiationbiological processThe cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. [ISBN:0198506732]