A retinal rod rhodopsin-sensitive cGMP 3,5-cyclic phosphodiesterase subunit gamma that is encoded in the genome of human. [PRO:DNx, UniProtKB:P18545]
GMP-PDE gamma;
EC 3.1.4.35
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (66.67) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| dipyridamole | Homo sapiens (human) | Ki | 0.1250 | 1 | 1 |
| tadalafil | Homo sapiens (human) | IC50 | 2.9280 | 5 | 5 |
| sildenafil | Homo sapiens (human) | IC50 | 0.0188 | 4 | 4 |
| sildenafil | Homo sapiens (human) | Ki | 0.0500 | 1 | 1 |
| zaprinast | Homo sapiens (human) | Ki | 0.4000 | 1 | 1 |
| vardenafil | Homo sapiens (human) | IC50 | 0.0077 | 3 | 3 |
This protein enables 5 target(s):
| Target | Category | Definition |
|---|---|---|
| enzyme inhibitor activity | molecular function | Binds to and stops, prevents or reduces the activity of an enzyme. [GOC:ai, GOC:ebc] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| spectrin binding | molecular function | Binding to spectrin, a protein that is the major constituent of the erythrocyte cytoskeletal network. It associates with band 4.1 (see band protein) and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. It is composed of nonhomologous chains, alpha and beta, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers. [GOC:mah, ISBN:0198506732] |
| cGMP binding | molecular function | Binding to cGMP, the nucleotide cyclic GMP (guanosine 3',5'-cyclophosphate). [GOC:ai] |
| 3',5'-cyclic-GMP phosphodiesterase activity | molecular function | Catalysis of the reaction: 3',5'-cyclic GMP + H2O = GMP + H+. [RHEA:16957] |
This protein is located in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| photoreceptor disc membrane | cellular component | Stack of disc membranes located inside a photoreceptor outer segment, and containing densely packed molecules of photoreceptor proteins that traverse the lipid bilayer. Disc membranes arise as evaginations of the ciliary membrane during the development of the outer segment and may or may not remain contiguous with the ciliary membrane. [GOC:bj, GOC:krc, GOC:pde, PMID:11826267, PMID:19501669, PMID:2537204, PMID:26574505, PMID:6771304, PMID:7507907] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| photoreceptor outer segment membrane | cellular component | The membrane surrounding the outer segment of a vertebrate photoreceptor. [GOC:jl] |
This protein is involved in 4 target(s):
| Target | Category | Definition |
|---|---|---|
| visual perception | biological process | The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image. [GOC:ai] |
| positive regulation of MAPK cascade | biological process | Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade. [GOC:go_curators] |
| positive regulation of epidermal growth factor receptor signaling pathway | biological process | Any process that activates or increases the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity. [GOC:go_curators] |
| positive regulation of G protein-coupled receptor signaling pathway | biological process | Any process that activates or increases the frequency, rate or extent of G protein-coupled receptor signaling pathway activity. [GOC:go_curators] |