A folate receptor alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:P15328]
FR-alpha;
Adult folate-binding protein;
FBP;
Folate receptor 1;
Folate receptor, adult;
KB cells FBP;
Ovarian tumor-associated antigen MOv18
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| methotrexate | Homo sapiens (human) | IC50 | 0.2262 | 4 | 4 |
| 10-propargyl-10-deazaaminopterin | Homo sapiens (human) | IC50 | 0.5840 | 2 | 2 |
| raltitrexed | Homo sapiens (human) | IC50 | 0.5075 | 4 | 4 |
| pemetrexed | Homo sapiens (human) | IC50 | 0.2417 | 6 | 6 |
This protein enables 4 target(s):
| Target | Category | Definition |
|---|---|---|
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| folic acid binding | molecular function | Binding to folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines. [GOC:jl, ISBN:0198506732] |
| folic acid receptor activity | molecular function | Combining selectively with extracellular folic acid and delivering it into the cell via endocytosis. [GOC:BHF, GOC:hal] |
| signaling receptor activity | molecular function | Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response. [GOC:bf, GOC:signaling] |
This protein is located in 16 target(s):
| Target | Category | Definition |
|---|---|---|
| Golgi membrane | cellular component | The lipid bilayer surrounding any of the compartments of the Golgi apparatus. [GOC:mah] |
| endosome | cellular component | A vacuole to which materials ingested by endocytosis are delivered. [ISBN:0198506732, PMID:19696797] |
| endoplasmic reticulum membrane | cellular component | The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah] |
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| external side of plasma membrane | cellular component | The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface. [GOC:dos, GOC:tb] |
| cell surface | cellular component | The external part of the cell wall and/or plasma membrane. [GOC:jl, GOC:mtg_sensu, GOC:sm] |
| ER to Golgi transport vesicle membrane | cellular component | The lipid bilayer surrounding a vesicle transporting substances from the endoplasmic reticulum to the Golgi. [GOC:ai, GOC:ascb_2009, GOC:dph, GOC:tb] |
| membrane | cellular component | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
| basolateral plasma membrane | cellular component | The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. [GOC:go_curators] |
| apical plasma membrane | cellular component | The region of the plasma membrane located at the apical end of the cell. [GOC:curators] |
| transport vesicle | cellular component | Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell. [GOC:mah, PMID:22160157] |
| clathrin-coated vesicle | cellular component | A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes. [GOC:mah, PMID:11252894] |
| brush border membrane | cellular component | The portion of the plasma membrane surrounding the brush border. [GOC:mah] |
| endoplasmic reticulum-Golgi intermediate compartment membrane | cellular component | The lipid bilayer surrounding any of the compartments of the endoplasmic reticulum (ER)-Golgi intermediate compartment system. [GOC:mah, GOC:pr, PMID:16723730] |
| extracellular exosome | cellular component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
| nucleus | cellular component | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| external side of plasma membrane | cellular component | The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface. [GOC:dos, GOC:tb] |
This protein is involved in 15 target(s):
| Target | Category | Definition |
|---|---|---|
| heart looping | biological process | The tube morphogenesis process in which the primitive heart tube loops asymmetrically. This looping brings the primitive heart chambers into alignment preceding their future integration. Heart looping begins with dextral-looping and ends when the main regional divisions of the mature heart and primordium of the great arterial trunks become established preceeding septation. [GOC:dph, PMID:12094232] |
| neural crest cell migration involved in heart formation | biological process | The characteristic movement of a cell from the dorsal ridge of the neural tube towards the heart and that contributes to heart formation. [GOC:mtg_heart] |
| cardiac neural crest cell migration involved in outflow tract morphogenesis | biological process | The orderly movement of a neural crest cell from one site to another that will contribute to the morphogenesis of the outflow tract. [GOC:mtg_heart] |
| receptor-mediated endocytosis | biological process | An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles. [GOC:mah, ISBN:0716731363] |
| folic acid transport | biological process | The directed movement of folic acid (pteroylglutamic acid) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines. [GOC:ai] |
| regulation of transforming growth factor beta receptor signaling pathway | biological process | Any process that modulates the frequency, rate or extent of activity of any TGF-beta receptor signaling pathway. [GOC:mah] |
| axon regeneration | biological process | The regrowth of axons following their loss or damage. [GOC:dgh, GOC:dph, GOC:tb] |
| folic acid metabolic process | biological process | The chemical reactions and pathways involving folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines. [ISBN:0198506732] |
| regulation of canonical Wnt signaling pathway | biological process | Any process that modulates the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. [GOC:dph, GOC:sdb_2009, GOC:tb] |
| pharyngeal arch artery morphogenesis | biological process | The process in which the anatomical structures of a pharyngeal arch artery is generated and organized. The pharyngeal arch arteries are a series of six paired embryological vascular structures, the development of which give rise to several major arteries, such as the stapedial artery, the middle meningeal artery, the internal carotid artery and the pulmonary artery. [GOC:BHF, GOC:dph, PMID:20122914] |
| anterior neural tube closure | biological process | The step in the formation of the neural tube, where the paired anterior neural folds are brought together and fuse at the dorsal midline. [GOC:BHF, GOC:dph, GOC:hal, PMID:17286298] |
| cellular response to folic acid | biological process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a folic acid stimulus. [GOC:mah] |
| cell adhesion | biological process | The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. [GOC:hb, GOC:pf] |
| fusion of sperm to egg plasma membrane involved in single fertilization | biological process | The binding and fusion of a sperm, with the plasma membrane of the oocyte as part of the process of single fertilization. In sperm with flagella, binding occurs at the posterior (post-acrosomal) region of the sperm head. [GOC:dph, GOC:jl, http://arbl.cvmbs.colostate.edu/hbooks/pathphys/reprod/fert/fert.html] |
| sperm-egg recognition | biological process | The initial contact step made between the sperm plasma membrane and outer layer of the egg during fertilization. [GOC:bf] |