Deoxycytidylate deaminase

A deoxycytidylate deaminase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P32321]

EC 3.5.4.12;
dCMP deaminase

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
deoxycytidine monophosphate	Homo sapiens (human)	Km	87.0000	1	1

This protein enables 5 target(s):

Target	Category	Definition
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
zinc ion binding	molecular function	Binding to a zinc ion (Zn). [GOC:ai]
identical protein binding	molecular function	Binding to an identical protein or proteins. [GOC:jl]
deoxyribonucleoside 5'-monophosphate N-glycosidase activity	molecular function	Catalysis of the reaction: a deoxyribonucleoside 5'-monophosphate + H2O = deoxyribose 5-monophosphate + a purine or pyrimidine base. [GOC:ab, PMID:17234634]
dCMP deaminase activity	molecular function	Catalysis of the reaction: dCMP + H2O = dUMP + NH3. [EC:3.5.4.12]

This protein is located in 1 target(s):

Target	Category	Definition
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

This protein is active in 1 target(s):

Target	Category	Definition
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]

This protein is involved in 4 target(s):

Target	Category	Definition
pyrimidine nucleotide metabolic process	biological process	The chemical reactions and pathways involving a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. [GOC:go_curators, ISBN:0198506732]
nucleotide biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates). [GOC:go_curators]
nucleoside salvage	biological process	Any process which produces a nucleotide, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose (a deoxyribonucleotide), from derivatives of it without de novo synthesis. [GOC:jl]
cytidine deamination	biological process	The removal of amino group in the presence of water. [GOC:sm]