5-hydroxydecanoate has been researched along with Necrosis in 8 studies
5-hydroxydecanoic acid: Potassium Channel Blocker; RN refers to parent cpd
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Levosimendan is a positive inotropic drug for the treatment of acute decompensated heart failure (HF)." | 3.81 | Levosimendan exerts anti-inflammatory effects on cardiac myocytes and endothelial cells in vitro. ( Aliabadi, A; Buchberger, E; de Martin, R; Demyanets, S; Gröger, M; Hofer-Warbinek, R; Huber, K; Kastl, SP; Kaun, C; Krychtiuk, KA; Maurer, G; Pisoni, J; Rauscher, S; Speidl, WS; Watzke, L; Wojta, J; Zuckermann, A, 2015) |
| " Preconditioning with 10 microM adenosine limited necrosis (10." | 3.72 | Adenosine-mediated early preconditioning in mouse: protective signaling and concentration dependent effects. ( Headrick, JP; Peart, J, 2003) |
| " Inhibition of mitochondrial K(ATP)channels with 5-hydroxydecanoate had no effect on baseline LVDP, LVEDP, or coronary flow but abolished the beneficial effects of alcohol on LV contractile recovery and myocyte necrosis." | 3.70 | Chronic ethanol-induced myocardial protection requires activation of mitochondrial K(ATP) channels. ( Gray, MO; Zhou, HZ; Zhu, P, 2000) |
| "Propofol treatments were initiated at various time intervals: 1 or 24 h before ischemia, only during ischemia, or only during reperfusion." | 1.35 | The role of KATP channels on propofol preconditioning in a cellular model of renal ischemia-reperfusion. ( Assad, AR; Capella, MA; Delou, JM; Fonseca, LM; Lopes, AG; Nascimento, JH; Verçosa, N; Villela, NR, 2009) |
| " In a first study to characterize effects of sex and the dose-response profile of estrogen on infarct size, the drug was intravenously administered at 10 or 20 microg/kg." | 1.31 | Cardioprotective effects of 17 beta-estradiol produced by activation ofmitochondrial ATP-sensitive K(+)Channels in canine hearts. ( Lee, TM; Lee, YT; Su, SF; Tsai, CC; Tsai, CH, 2000) |
| "Myocardial infarction was induced by occlusion of the anterior descending coronary artery for 60 min and reperfusion for 270 min." | 1.31 | Mitochondrial ATP dependent potassium channels mediate non-ischemic preconditioning by tachycardia in dogs. ( Domenech, R; Macho, P; Sánchez, G; Schwarze, H; Solis, E, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (75.00) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Krychtiuk, KA | 1 |
| Watzke, L | 1 |
| Kaun, C | 1 |
| Buchberger, E | 1 |
| Hofer-Warbinek, R | 1 |
| Demyanets, S | 1 |
| Pisoni, J | 1 |
| Kastl, SP | 1 |
| Rauscher, S | 1 |
| Gröger, M | 1 |
| Aliabadi, A | 1 |
| Zuckermann, A | 1 |
| Maurer, G | 1 |
| de Martin, R | 1 |
| Huber, K | 1 |
| Wojta, J | 1 |
| Speidl, WS | 1 |
| Liang, W | 1 |
| Chen, M | 1 |
| Zheng, D | 1 |
| Li, J | 1 |
| Song, M | 1 |
| Zhang, W | 1 |
| Feng, J | 1 |
| Lan, J | 1 |
| Assad, AR | 1 |
| Delou, JM | 1 |
| Fonseca, LM | 1 |
| Villela, NR | 1 |
| Nascimento, JH | 1 |
| Verçosa, N | 1 |
| Lopes, AG | 1 |
| Capella, MA | 1 |
| Peart, J | 1 |
| Headrick, JP | 1 |
| Lee, TM | 1 |
| Su, SF | 1 |
| Tsai, CC | 1 |
| Lee, YT | 1 |
| Tsai, CH | 1 |
| Zhu, P | 1 |
| Zhou, HZ | 1 |
| Gray, MO | 1 |
| Hale, SL | 1 |
| Kloner, RA | 1 |
| Macho, P | 1 |
| Solis, E | 1 |
| Sánchez, G | 1 |
| Schwarze, H | 1 |
| Domenech, R | 1 |
8 other studies available for 5-hydroxydecanoate and Necrosis
| Article | Year |
|---|---|
Levosimendan exerts anti-inflammatory effects on cardiac myocytes and endothelial cells in vitro.
Topics: Anti-Inflammatory Agents; Cell Adhesion; Cells, Cultured; Decanoic Acids; E-Selectin; Enzyme-Linked | 2015 |
The Opening of ATP-Sensitive K+ Channels Protects H9c2 Cardiac Cells Against the High Glucose-Induced Injury and Inflammation by Inhibiting the ROS-TLR4-Necroptosis Pathway.
Topics: Acetylcysteine; Animals; Apoptosis; Cell Line; Decanoic Acids; Diazoxide; Gene Expression Regulation | 2017 |
The role of KATP channels on propofol preconditioning in a cellular model of renal ischemia-reperfusion.
Topics: Adenosine Triphosphate; Animals; Antimycin A; Apoptosis; Cell Survival; Cytoprotection; Decanoic Aci | 2009 |
Adenosine-mediated early preconditioning in mouse: protective signaling and concentration dependent effects.
Topics: Adenosine; Adenosine Diphosphate; Alkaloids; Animals; Benzophenanthridines; Calcium Channel Blockers | 2003 |
Cardioprotective effects of 17 beta-estradiol produced by activation ofmitochondrial ATP-sensitive K(+)Channels in canine hearts.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Blood Flow Velocity; Decanoic Acids; Dogs; | 2000 |
Chronic ethanol-induced myocardial protection requires activation of mitochondrial K(ATP) channels.
Topics: Alcohol Drinking; Animals; Coronary Circulation; Creatine Kinase; Decanoic Acids; Ethanol; Hydroxy A | 2000 |
Effect of combined K(ATP) channel activation and Na(+)/H(+) exchange inhibition on infarct size in rabbits.
Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Decanoic Acids; Diazoxide; Guanidines; Heart Rate; | 2000 |
Mitochondrial ATP dependent potassium channels mediate non-ischemic preconditioning by tachycardia in dogs.
Topics: Adenosine; Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Blood Flow Velocity; Decanoic Ac | 2001 |