Proteins > NAD-dependent histone deacetylase SIR2
Page last updated: 2024-08-07 12:53:12

NAD-dependent histone deacetylase SIR2

A protein that is a translation product of the SIR2 gene in yeast. [PRO:DNx, UniProtKB:P06700]

Synonyms

EC 2.3.1.286;
Regulatory protein SIR2;
Silent information regulator 2

Research

Bioassay Publications (4)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (50.00)29.6817
2010's2 (50.00)24.3611
2020's0 (0.00)2.80

Compounds (8)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
coumarinSaccharomyces cerevisiae S288CIC50150.000011
3,4-dihydrocoumarinSaccharomyces cerevisiae S288CIC50122.000011
niacinamideSaccharomyces cerevisiae S288CIC5050.000011
fenofibrateSaccharomyces cerevisiae S288CIC5067.000022
1,8-naphthalenedicarboxylic acid anhydrideSaccharomyces cerevisiae S288CIC508.800011
2(3h)-benzofuranoneSaccharomyces cerevisiae S288CIC50150.000011
1-keto-1,2,3,4-tetrahydrophenanthreneSaccharomyces cerevisiae S288CIC5081.000011
sirtinolSaccharomyces cerevisiae S288CIC5058.000022

Drugs with Other Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
coumarinSaccharomyces cerevisiae S288CInhibition0.740011
coumarinSaccharomyces cerevisiae S288CMGC150.000011
3,4-dihydrocoumarinSaccharomyces cerevisiae S288CInhibition0.150011
3,4-dihydrocoumarinSaccharomyces cerevisiae S288CMGC0.850011
fenofibrateSaccharomyces cerevisiae S288CInhibition0.660011
fenofibrateSaccharomyces cerevisiae S288CMGC0.490011
1,8-naphthalenedicarboxylic acid anhydrideSaccharomyces cerevisiae S288CInhibition0.940011
1,8-naphthalenedicarboxylic acid anhydrideSaccharomyces cerevisiae S288CMGC150.000011
2(3h)-benzofuranoneSaccharomyces cerevisiae S288CInhibition0.890011
2(3h)-benzofuranoneSaccharomyces cerevisiae S288CMGC24.000011
1-keto-1,2,3,4-tetrahydrophenanthreneSaccharomyces cerevisiae S288CMGC150.000011