Page last updated: 2024-08-07 12:53:12
NAD-dependent histone deacetylase SIR2
A protein that is a translation product of the SIR2 gene in yeast. [PRO:DNx, UniProtKB:P06700]
Synonyms
EC 2.3.1.286;
Regulatory protein SIR2;
Silent information regulator 2
Research
Bioassay Publications (4)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (8)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| coumarin | Saccharomyces cerevisiae S288C | IC50 | 150.0000 | 1 | 1 |
| 3,4-dihydrocoumarin | Saccharomyces cerevisiae S288C | IC50 | 122.0000 | 1 | 1 |
| niacinamide | Saccharomyces cerevisiae S288C | IC50 | 50.0000 | 1 | 1 |
| fenofibrate | Saccharomyces cerevisiae S288C | IC50 | 67.0000 | 2 | 2 |
| 1,8-naphthalenedicarboxylic acid anhydride | Saccharomyces cerevisiae S288C | IC50 | 8.8000 | 1 | 1 |
| 2(3h)-benzofuranone | Saccharomyces cerevisiae S288C | IC50 | 150.0000 | 1 | 1 |
| 1-keto-1,2,3,4-tetrahydrophenanthrene | Saccharomyces cerevisiae S288C | IC50 | 81.0000 | 1 | 1 |
| sirtinol | Saccharomyces cerevisiae S288C | IC50 | 58.0000 | 2 | 2 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| coumarin | Saccharomyces cerevisiae S288C | Inhibition | 0.7400 | 1 | 1 |
| coumarin | Saccharomyces cerevisiae S288C | MGC | 150.0000 | 1 | 1 |
| 3,4-dihydrocoumarin | Saccharomyces cerevisiae S288C | Inhibition | 0.1500 | 1 | 1 |
| 3,4-dihydrocoumarin | Saccharomyces cerevisiae S288C | MGC | 0.8500 | 1 | 1 |
| fenofibrate | Saccharomyces cerevisiae S288C | Inhibition | 0.6600 | 1 | 1 |
| fenofibrate | Saccharomyces cerevisiae S288C | MGC | 0.4900 | 1 | 1 |
| 1,8-naphthalenedicarboxylic acid anhydride | Saccharomyces cerevisiae S288C | Inhibition | 0.9400 | 1 | 1 |
| 1,8-naphthalenedicarboxylic acid anhydride | Saccharomyces cerevisiae S288C | MGC | 150.0000 | 1 | 1 |
| 2(3h)-benzofuranone | Saccharomyces cerevisiae S288C | Inhibition | 0.8900 | 1 | 1 |
| 2(3h)-benzofuranone | Saccharomyces cerevisiae S288C | MGC | 24.0000 | 1 | 1 |
| 1-keto-1,2,3,4-tetrahydrophenanthrene | Saccharomyces cerevisiae S288C | MGC | 150.0000 | 1 | 1 |