Page last updated: 2024-08-07 16:13:11
Carbonic anhydrase 4
A carbonic anhydrase 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P22748]
Synonyms
EC 4.2.1.1;
Carbonate dehydratase IV;
Carbonic anhydrase IV;
CA-IV
Research
Bioassay Publications (141)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 2 (1.42) | 18.7374 |
| 1990's | 2 (1.42) | 18.2507 |
| 2000's | 44 (31.21) | 29.6817 |
| 2010's | 73 (51.77) | 24.3611 |
| 2020's | 20 (14.18) | 2.80 |
Compounds (211)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| protocatechuic acid | Homo sapiens (human) | Ki | 2.4500 | 1 | 1 |
| 4-hydroxybenzoic acid | Homo sapiens (human) | Ki | 302.3362 | 3 | 16 |
| bromide | Homo sapiens (human) | Ki | 13,459.6000 | 1 | 5 |
| hydrobromic acid | Homo sapiens (human) | Ki | 26,045.0000 | 2 | 2 |
| cadaverine | Homo sapiens (human) | Ki | 0.0520 | 1 | 1 |
| carbamyl phosphate | Homo sapiens (human) | Ki | 9.9000 | 1 | 1 |
| catechol | Homo sapiens (human) | Ki | 596.8438 | 7 | 24 |
| chlorine | Homo sapiens (human) | Ki | 51,543.8250 | 1 | 4 |
| hydrochloric acid | Homo sapiens (human) | Ki | 18,045.0000 | 2 | 2 |
| coumarin | Homo sapiens (human) | Ki | 34.5500 | 2 | 2 |
| salicylic acid | Homo sapiens (human) | Ki | 161.9571 | 2 | 14 |
| gallic acid | Homo sapiens (human) | Ki | 9.8000 | 1 | 1 |
| hydrogen sulfide | Homo sapiens (human) | Ki | 3,900.0000 | 1 | 1 |
| 4-aminophenol | Homo sapiens (human) | Ki | 531.9357 | 2 | 14 |
| guaiacol | Homo sapiens (human) | Ki | 100.1540 | 1 | 5 |
| cyanic acid | Homo sapiens (human) | Ki | 610.0000 | 1 | 1 |
| carbonic acid | Homo sapiens (human) | Ki | 15,500.0000 | 3 | 4 |
| hydrogen cyanide | Homo sapiens (human) | Ki | 770.0000 | 1 | 1 |
| hydrogen carbonate | Homo sapiens (human) | Ki | 25,902.0500 | 1 | 4 |
| thiocyanic acid | Homo sapiens (human) | Ki | 39,000.0000 | 1 | 1 |
| hydroquinone | Homo sapiens (human) | Ki | 121.4439 | 3 | 18 |
| indole | Homo sapiens (human) | Ki | 2.3300 | 1 | 1 |
| naringenin | Homo sapiens (human) | Ki | 1.1806 | 1 | 5 |
| nitrates | Homo sapiens (human) | Ki | 25,192.1750 | 1 | 4 |
| nitric acid | Homo sapiens (human) | Ki | 58,700.0000 | 2 | 2 |
| nitrites | Homo sapiens (human) | Ki | 25,565.3000 | 1 | 4 |
| phenol | Homo sapiens (human) | Ki | 110.2068 | 8 | 25 |
| pyrogallol | Homo sapiens (human) | Ki | 3.7975 | 1 | 4 |
| sulfurous acid | Homo sapiens (human) | Ki | 13,200.0000 | 1 | 1 |
| spermidine | Homo sapiens (human) | Ki | 0.1120 | 1 | 1 |
| spermine | Homo sapiens (human) | Ki | 0.0100 | 1 | 1 |
| sulfuric acid | Homo sapiens (human) | Ki | 20,666.6667 | 3 | 3 |
| catechin | Homo sapiens (human) | Ki | 4.9000 | 1 | 1 |
| acetaminophen | Homo sapiens (human) | Ki | 148.2231 | 2 | 13 |
| acetazolamide | Homo sapiens (human) | IC50 | 0.1216 | 3 | 4 |
| acetazolamide | Homo sapiens (human) | Ki | 10.0310 | 93 | 155 |
| bumetanide | Homo sapiens (human) | Ki | 18.3242 | 1 | 12 |
| celecoxib | Homo sapiens (human) | Ki | 0.6440 | 5 | 5 |
| chlorthalidone | Homo sapiens (human) | Ki | 1.3230 | 2 | 14 |
| coumaphos | Homo sapiens (human) | Ki | 5.4800 | 1 | 1 |
| dichlorphenamide | Homo sapiens (human) | Ki | 31.9482 | 9 | 31 |
| ethoxzolamide | Homo sapiens (human) | Ki | 8.3473 | 12 | 26 |
| foscarnet | Homo sapiens (human) | Ki | 820.0000 | 1 | 1 |
| furosemide | Homo sapiens (human) | Ki | 14.6201 | 2 | 14 |
| hydrochlorothiazide | Homo sapiens (human) | Ki | 18.6042 | 1 | 12 |
| hydroflumethiazide | Homo sapiens (human) | Ki | 20.3203 | 1 | 12 |
| hydroxyurea | Homo sapiens (human) | Ki | 113.0000 | 1 | 1 |
| indapamide | Homo sapiens (human) | Ki | 18.7742 | 2 | 14 |
| mafenide | Homo sapiens (human) | Ki | 5.7000 | 2 | 2 |
| methazolamide | Homo sapiens (human) | IC50 | 0.0792 | 2 | 3 |
| methazolamide | Homo sapiens (human) | Ki | 10.0504 | 10 | 25 |
| metolazone | Homo sapiens (human) | Ki | 22.0639 | 1 | 12 |
| potassium chloride | Homo sapiens (human) | Ki | 90.0000 | 1 | 1 |
| potassium iodide | Homo sapiens (human) | Ki | 80.0000 | 1 | 1 |
| resorcinol | Homo sapiens (human) | Ki | 333.9158 | 4 | 19 |
| resveratrol | Homo sapiens (human) | Ki | 4.0100 | 1 | 1 |
| saccharin | Homo sapiens (human) | Ki | 7.9200 | 2 | 2 |
| imatinib | Homo sapiens (human) | Ki | 4.5530 | 1 | 1 |
| sulfanilamide | Homo sapiens (human) | Ki | 8.0700 | 4 | 4 |
| sulthiame | Homo sapiens (human) | Ki | 52.8232 | 1 | 12 |
| trichlormethiazide | Homo sapiens (human) | Ki | 43.7840 | 2 | 26 |
| trientine | Homo sapiens (human) | Ki | 35.0000 | 1 | 1 |
| wb 4101 | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| zonisamide | Homo sapiens (human) | IC50 | 1.8600 | 1 | 1 |
| zonisamide | Homo sapiens (human) | Ki | 98.2498 | 7 | 25 |
| cyanides | Homo sapiens (human) | Ki | 199.9750 | 1 | 4 |
| sulfamic acid | Homo sapiens (human) | Ki | 75.4150 | 5 | 8 |
| carbostyril | Homo sapiens (human) | Ki | 0.3600 | 2 | 2 |
| sodium citrate, anhydrous | Homo sapiens (human) | Ki | 0.0990 | 1 | 1 |
| quinethazone | Homo sapiens (human) | Ki | 18.1300 | 1 | 2 |
| veratrole | Homo sapiens (human) | Ki | 14.3200 | 2 | 2 |
| 4-phenylphenol | Homo sapiens (human) | Ki | 31.0825 | 1 | 4 |
| veratric acid | Homo sapiens (human) | Ki | 6.4800 | 1 | 1 |
| benzenearsonic acid | Homo sapiens (human) | Ki | 15,811.6567 | 3 | 6 |
| benzenesulfonamide | Homo sapiens (human) | IC50 | 2.0000 | 1 | 1 |
| benzenesulfonamide | Homo sapiens (human) | Ki | 1.1200 | 1 | 1 |
| anisole | Homo sapiens (human) | Ki | 14.3200 | 1 | 1 |
| diethylenetriamine | Homo sapiens (human) | Ki | 116.0000 | 1 | 1 |
| malic acid, disodium salt | Homo sapiens (human) | Ki | 53.7000 | 1 | 1 |
| catechin | Homo sapiens (human) | Ki | 6.0775 | 2 | 4 |
| thiocyanate | Homo sapiens (human) | Ki | 10,202.5250 | 1 | 4 |
| ninhydrin | Homo sapiens (human) | Ki | 100.0000 | 1 | 1 |
| sodium carbonate | Homo sapiens (human) | Ki | 5,700.0000 | 1 | 1 |
| syringic acid | Homo sapiens (human) | Ki | 10.6000 | 1 | 1 |
| herniarin | Homo sapiens (human) | Ki | 8.3000 | 1 | 1 |
| coumarin-3-carboxylic acid | Homo sapiens (human) | Ki | 9.7000 | 1 | 1 |
| 2-methylcyclohexanone | Homo sapiens (human) | Ki | 8.9300 | 1 | 1 |
| 4-cyanophenol | Homo sapiens (human) | Ki | 247.7720 | 2 | 14 |
| methylphosphonic acid | Homo sapiens (human) | Ki | 310.0000 | 1 | 1 |
| hydrofluoric acid | Homo sapiens (human) | Ki | 70.0000 | 1 | 1 |
| n-(1-naphthyl)ethylenediamine | Homo sapiens (human) | Ki | 0.0580 | 1 | 1 |
| phenylphosphonic acid | Homo sapiens (human) | Ki | 5.4000 | 1 | 1 |
| methylene diphosphonate | Homo sapiens (human) | Ki | 5,340.0000 | 1 | 1 |
| 1,6-diaminohexane | Homo sapiens (human) | Ki | 0.4500 | 1 | 1 |
| benzolamide | Homo sapiens (human) | Ki | 15.5829 | 2 | 9 |
| chloric acid | Homo sapiens (human) | Ki | 64,900.0000 | 1 | 1 |
| carbonates | Homo sapiens (human) | Ki | 23,451.5000 | 1 | 4 |
| benzeneseleninic acid | Homo sapiens (human) | Ki | 100.0000 | 1 | 1 |
| phosphoric acid, trisodium salt | Homo sapiens (human) | Ki | 0.0840 | 1 | 1 |
| perchloric acid | Homo sapiens (human) | Ki | 767,000.0000 | 1 | 1 |
| iodic acid | Homo sapiens (human) | Ki | 108,700.0000 | 1 | 1 |
| sodium pyrophosphate | Homo sapiens (human) | Ki | 1,010.0000 | 1 | 1 |
| potassium nitrate | Homo sapiens (human) | Ki | 58,700.0000 | 1 | 1 |
| sodium sulfate | Homo sapiens (human) | Ki | 9,000.0000 | 1 | 1 |
| bromic acid | Homo sapiens (human) | Ki | 128,000.0000 | 1 | 1 |
| nitrous acid | Homo sapiens (human) | Ki | 30,800.0000 | 1 | 1 |
| hydrazoic acid | Homo sapiens (human) | Ki | 65,100.0000 | 1 | 1 |
| hydroiodic acid | Homo sapiens (human) | Ki | 5,540.0000 | 2 | 2 |
| sodium selenate | Homo sapiens (human) | Ki | 138,000.0000 | 1 | 1 |
| fluorides | Homo sapiens (human) | Ki | 150,031.1000 | 1 | 4 |
| iodine | Homo sapiens (human) | Ki | 6,667.0000 | 1 | 4 |
| sodium azide | Homo sapiens (human) | Ki | 65,100.0000 | 1 | 1 |
| azides | Homo sapiens (human) | Ki | 16,652.4250 | 1 | 4 |
| 7-ethoxycoumarin | Homo sapiens (human) | Ki | 35.7000 | 1 | 1 |
| dobutamine | Homo sapiens (human) | Ki | 8.9800 | 1 | 1 |
| foscarnet sodium | Homo sapiens (human) | Ki | 820.0000 | 2 | 2 |
| succinylsulfanilamide | Homo sapiens (human) | Ki | 0.4860 | 1 | 1 |
| sodium persulfate | Homo sapiens (human) | Ki | 1,000.0000 | 1 | 1 |
| metaperiodate | Homo sapiens (human) | Ki | 226,000.0000 | 1 | 1 |
| 4-chlorobenzenesulfonamide | Homo sapiens (human) | Ki | 0.0003 | 1 | 1 |
| benzeneboronic acid | Homo sapiens (human) | Ki | 10,323.9150 | 5 | 8 |
| 4-amino-6-chloro-1,3-benzenedisulfonamide | Homo sapiens (human) | Ki | 0.2700 | 2 | 2 |
| plasmenylserine | Homo sapiens (human) | Ki | 4,260.0000 | 1 | 1 |
| brinzolamide | Homo sapiens (human) | IC50 | 0.0313 | 2 | 3 |
| brinzolamide | Homo sapiens (human) | Ki | 3.9500 | 2 | 2 |
| 2,4-disulfamyl-5-trifluoromethylaniline | Homo sapiens (human) | Ki | 4.8300 | 1 | 1 |
| epicatechin | Homo sapiens (human) | Ki | 4.1660 | 1 | 5 |
| hesperetin | Homo sapiens (human) | Ki | 0.1021 | 1 | 1 |
| methanesulfonamide | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| 2-aminobenzenesulfonamide | Homo sapiens (human) | Ki | 1.3100 | 1 | 1 |
| 3,7-diazanonane-1,9-diamine | Homo sapiens (human) | Ki | 44.0000 | 1 | 1 |
| sulfamide | Homo sapiens (human) | Ki | 172.4222 | 6 | 9 |
| 5-amino-1,3,4-thiadiazole-2-sulfonamide | Homo sapiens (human) | Ki | 0.8067 | 3 | 3 |
| aminozolamide | Homo sapiens (human) | Ki | 0.0190 | 1 | 1 |
| 6-hydroxyethoxzolamide | Homo sapiens (human) | Ki | 0.0150 | 1 | 1 |
| hydrogen sulfite | Homo sapiens (human) | Ki | 30,052.4250 | 1 | 4 |
| cyanates | Homo sapiens (human) | Ki | 167.0750 | 1 | 4 |
| valdecoxib | Homo sapiens (human) | Ki | 1.0067 | 3 | 3 |
| estrone-3-o-sulfamate | Homo sapiens (human) | Ki | 1.0400 | 1 | 1 |
| 1-naphthylacetylspermine | Homo sapiens (human) | Ki | 0.0180 | 1 | 1 |
| 4-(2-aminoethyl)benzenesulfonamide | Homo sapiens (human) | Ki | 2.1396 | 3 | 3 |
| lacosamide | Homo sapiens (human) | Ki | 0.5250 | 1 | 1 |
| potassium bromide | Homo sapiens (human) | Ki | 90.0000 | 1 | 1 |
| u-104 | Homo sapiens (human) | Ki | 0.2860 | 2 | 2 |
| bortezomib | Homo sapiens (human) | Ki | 6.5100 | 1 | 1 |
| naringenin | Homo sapiens (human) | Ki | 0.0795 | 1 | 1 |
| taxifolin | Homo sapiens (human) | Ki | 9.0982 | 1 | 1 |
| eriodictyol | Homo sapiens (human) | Ki | 0.0728 | 1 | 1 |
| resveratrol | Homo sapiens (human) | Ki | 4.4700 | 1 | 1 |
| rwj 37947 | Homo sapiens (human) | Ki | 0.0360 | 1 | 1 |
| ferulic acid | Homo sapiens (human) | Ki | 10.8000 | 1 | 1 |
| sodium thiocyanate | Homo sapiens (human) | Ki | 39,000.0000 | 1 | 1 |
| sodium bicarbonate | Homo sapiens (human) | Ki | 6,600.0000 | 2 | 2 |
| sodium acetate, anhydrous | Homo sapiens (human) | Ki | 550.0000 | 1 | 1 |
| sodium benzoate | Homo sapiens (human) | Ki | 74.7000 | 1 | 1 |
| potassium fluoride | Homo sapiens (human) | Ki | 70.0000 | 1 | 1 |
| ditiocarb sodium | Homo sapiens (human) | Ki | 6.5000 | 1 | 1 |
| hydroxyphenethylferulate | Homo sapiens (human) | Ki | 44.0000 | 1 | 1 |
| 2-hydroxycinnamic acid | Homo sapiens (human) | Ki | 62.3000 | 1 | 1 |
| trans-4-coumaric acid | Homo sapiens (human) | Ki | 9.6000 | 1 | 1 |
| s 1033 | Homo sapiens (human) | Ki | 0.4460 | 1 | 1 |
| caffeic acid | Homo sapiens (human) | Ki | 10.1000 | 1 | 1 |
| 7-methoxy-2-oxo-1-benzopyran-3-carboxylic acid ethyl ester | Homo sapiens (human) | Ki | 7.2000 | 1 | 1 |
| formic acid, sodium salt | Homo sapiens (human) | Ki | 1,250.0000 | 2 | 2 |
| sitagliptin | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| sodium hexafluorophosphate | Homo sapiens (human) | Ki | 19,100.0000 | 1 | 1 |
| quercetin | Homo sapiens (human) | Ki | 6.7533 | 3 | 6 |
| biochanin a | Homo sapiens (human) | Ki | 7.0785 | 1 | 1 |
| apigenin | Homo sapiens (human) | Ki | 6.8750 | 1 | 4 |
| luteolin | Homo sapiens (human) | Ki | 2.6066 | 2 | 5 |
| quercetin 3-o-glucopyranoside | Homo sapiens (human) | Ki | 0.0757 | 1 | 1 |
| kaempferol | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| chrysin | Homo sapiens (human) | Ki | 0.5377 | 1 | 1 |
| galangin | Homo sapiens (human) | Ki | 0.5683 | 1 | 1 |
| 3-methylquercetin | Homo sapiens (human) | Ki | 0.2129 | 1 | 1 |
| morin | Homo sapiens (human) | Ki | 13.5500 | 1 | 4 |
| daidzein | Homo sapiens (human) | Ki | 0.7187 | 1 | 1 |
| salvianolic acid a | Homo sapiens (human) | Ki | 0.0666 | 1 | 1 |
| puerarin | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| ellagic acid | Homo sapiens (human) | Ki | 9.0800 | 1 | 1 |
| astragalin | Homo sapiens (human) | Ki | 5.5912 | 1 | 1 |
| dorzolamide | Homo sapiens (human) | IC50 | 0.0262 | 2 | 3 |
| dorzolamide | Homo sapiens (human) | Ki | 42.3007 | 10 | 21 |
| topiramate | Homo sapiens (human) | Ki | 27.7630 | 10 | 30 |
| irosustat | Homo sapiens (human) | Ki | 54.4255 | 2 | 13 |
| tiliroside | Homo sapiens (human) | Ki | 5.4687 | 1 | 1 |
| 3-cyano-7-hydroxycoumarin | Homo sapiens (human) | Ki | 48.2209 | 1 | 11 |
| famotidine | Homo sapiens (human) | Ki | 0.9388 | 1 | 1 |
| lithospermic acid | Homo sapiens (human) | Ki | 0.1012 | 1 | 1 |
| 6-hydroxybenzothiazide-2-sulfonamide | Homo sapiens (human) | Ki | 0.0170 | 1 | 1 |
| sodium bisulfate | Homo sapiens (human) | Ki | 1,100.0000 | 1 | 1 |
| cryolite | Homo sapiens (human) | Ki | 124,000.0000 | 1 | 1 |
| sodium lactate | Homo sapiens (human) | Ki | 1,530.0000 | 1 | 1 |
| sodium nitrite | Homo sapiens (human) | Ki | 30,800.0000 | 1 | 1 |
| dodoneine | Homo sapiens (human) | Ki | 9.6100 | 1 | 1 |
Drugs with Activation Measurements
Drugs with Other Measurements
Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid.Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008
Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the methanoarchaeon Methanobacterium thermoautotrophicum (Cab) with anions.Bioorganic & medicinal chemistry letters, , Sep-06, Volume: 14, Issue:17, 2004
Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Analysis of saponins and phenolic compounds as inhibitors of α-carbonic anhydrase isoenzymes.Journal of enzyme inhibition and medicinal chemistry, , Volume: 28, Issue:2, 2013
Carbonic anhydrase inhibitors: in vitro inhibition of α isoforms (hCA I, hCA II, bCA III, hCA IV) by flavonoids.Journal of enzyme inhibition and medicinal chemistry, , Volume: 28, Issue:2, 2013
Simple methanesulfonates are hydrolyzed by the sulfatase carbonic anhydrase activity.Journal of enzyme inhibition and medicinal chemistry, , Volume: 27, Issue:6, 2012
Structure-activity relationships for the interaction of 5,10-dihydroindeno[1,2-b]indole derivatives with human and bovine carbonic anhydrase isoforms I, II, III, IV and VI.European journal of medicinal chemistry, , Volume: 49, 2012
Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid.Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008
Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the methanoarchaeon Methanobacterium thermoautotrophicum (Cab) with anions.Bioorganic & medicinal chemistry letters, , Sep-06, Volume: 14, Issue:17, 2004
Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
New chemotypes acting as isozyme-selective carbonic anhydrase inhibitors with low affinity for the offtarget cytosolic isoform II.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 22, Issue:6, 2012
Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins.Journal of medicinal chemistry, , Jan-14, Volume: 53, Issue:1, 2010
Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V, and IX with anions isosteric and isoelectronic with sulfate, nitrate, and carbonate.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 15, Issue:3, 2005
Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the methanoarchaeon Methanobacterium thermoautotrophicum (Cab) with anions.Bioorganic & medicinal chemistry letters, , Sep-06, Volume: 14, Issue:17, 2004
Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Binding site comparison for coumarin inhibitors and amine/amino acid activators of human carbonic anhydrases.European journal of medicinal chemistry, , Dec-15, Volume: 226, 2021
α-Carbonic anhydrases are strongly activated by spinaceamine derivatives.Bioorganic & medicinal chemistry, , 03-01, Volume: 27, Issue:5, 2019
Carbonic anhydrase activators. Activation of the membrane-associated isoform XV with amino acids and amines.Bioorganic & medicinal chemistry letters, , Jul-01, Volume: 19, Issue:13, 2009
Sildenafil is a strong activator of mammalian carbonic anhydrase isoforms I-XIV.Bioorganic & medicinal chemistry, , Aug-15, Volume: 17, Issue:16, 2009
Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 18, Issue:15, 2008
Carbonic anhydrase activators: L-Adrenaline plugs the active site entrance of isozyme II, activating better isoforms I, IV, VA, VII, and XIV.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 17, Issue:3, 2007
Carbonic anhydrase activators: X-ray crystal structure of the adduct of human isozyme II with L-histidine as a platform for the design of stronger activators.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 15, Issue:23, 2005
Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V, and IX with anions isosteric and isoelectronic with sulfate, nitrate, and carbonate.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 15, Issue:3, 2005
Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Analysis of saponins and phenolic compounds as inhibitors of α-carbonic anhydrase isoenzymes.Journal of enzyme inhibition and medicinal chemistry, , Volume: 28, Issue:2, 2013
Carbonic anhydrase inhibitors: in vitro inhibition of α isoforms (hCA I, hCA II, bCA III, hCA IV) by flavonoids.Journal of enzyme inhibition and medicinal chemistry, , Volume: 28, Issue:2, 2013
Synthesis of C-cinnamoyl glycosides and their inhibitory activity against mammalian carbonic anhydrases.Bioorganic & medicinal chemistry, , Mar-15, Volume: 21, Issue:6, 2013
Simple methanesulfonates are hydrolyzed by the sulfatase carbonic anhydrase activity.Journal of enzyme inhibition and medicinal chemistry, , Volume: 27, Issue:6, 2012
Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 20, Issue:17, 2010
Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule.Journal of medicinal chemistry, , Aug-12, Volume: 53, Issue:15, 2010
Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid.Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008
Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V, and IX with anions isosteric and isoelectronic with sulfate, nitrate, and carbonate.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 15, Issue:3, 2005
Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the methanoarchaeon Methanobacterium thermoautotrophicum (Cab) with anions.Bioorganic & medicinal chemistry letters, , Sep-06, Volume: 14, Issue:17, 2004
Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Discovery of a Potent and Highly Selective Dipeptidyl Peptidase IV and Carbonic Anhydrase Inhibitor as "Antidiabesity" Agents Based on Repurposing and Morphing of WB-4101.Journal of medicinal chemistry, , 10-27, Volume: 65, Issue:20, 2022
[no title available]Journal of medicinal chemistry, , 10-13, Volume: 65, Issue:19, 2022
2-(2-Hydroxyethyl)piperazine derivatives as potent human carbonic anhydrase inhibitors: Synthesis, enzyme inhibition, computational studies and antiglaucoma activity.European journal of medicinal chemistry, , Jan-15, Volume: 228, 2022
Recent advances in the medicinal chemistry of carbonic anhydrase inhibitors.European journal of medicinal chemistry, , Jan-01, Volume: 209, 2021
Novel benzenesulfonamides aryl and arylsulfone conjugates adopting tail/dual tail approaches: Synthesis, carbonic anhydrase inhibitory activity and molecular modeling studies.European journal of medicinal chemistry, , Oct-05, Volume: 221, 2021
Tellurides bearing benzensulfonamide as carbonic anhydrase inhibitors with potent antitumor activity.Bioorganic & medicinal chemistry letters, , 08-01, Volume: 45, 2021
Ninhydrins inhibit carbonic anhydrases directly binding to the metal ion.European journal of medicinal chemistry, , Jan-01, Volume: 209, 2021
Inhibition studies on carbonic anhydrase isoforms I, II, IV and IX with N-arylsubstituted secondary sulfonamides featuring a bicyclic tetrahydroindazole scaffold.European journal of medicinal chemistry, , Aug-05, Volume: 220, 2021
Chalcogenides-incorporating carbonic anhydrase inhibitors concomitantly reverted oxaliplatin-induced neuropathy and enhanced antiproliferative action.European journal of medicinal chemistry, , Dec-05, Volume: 225, 2021
Inhibition of Carbonic Anhydrase Using SLC-149: Support for a Noncatalytic Function of CAIX in Breast Cancer.Journal of medicinal chemistry, , 02-11, Volume: 64, Issue:3, 2021
Handling drug-target selectivity: A study on ureido containing Carbonic Anhydrase inhibitors.European journal of medicinal chemistry, , Feb-15, Volume: 212, 2021
Sulfonamide Inhibitors of Human Carbonic Anhydrases Designed through a Three-Tails Approach: Improving Ligand/Isoform Matching and Selectivity of Action.Journal of medicinal chemistry, , 07-09, Volume: 63, Issue:13, 2020
Bioisosteric Development of Multitarget Nonsteroidal Anti-Inflammatory Drug-Carbonic Anhydrases Inhibitor Hybrids for the Management of Rheumatoid Arthritis.Journal of medicinal chemistry, , 03-12, Volume: 63, Issue:5, 2020
Structural Basis of Nanomolar Inhibition of Tumor-Associated Carbonic Anhydrase IX: X-Ray Crystallographic and Inhibition Study of Lipophilic Inhibitors with Acetazolamide Backbone.Journal of medicinal chemistry, , 11-12, Volume: 63, Issue:21, 2020
Glycomimetic Based Approach toward Selective Carbonic Anhydrase Inhibitors.ACS medicinal chemistry letters, , May-14, Volume: 11, Issue:5, 2020
Phenyl(thio)phosphon(amid)ate Benzenesulfonamides as Potent and Selective Inhibitors of Human Carbonic Anhydrases II and VII Counteract Allodynia in a Mouse Model of Oxaliplatin-Induced Neuropathy.Journal of medicinal chemistry, , 05-28, Volume: 63, Issue:10, 2020
Discovery of Potent Dual-Tailed Benzenesulfonamide Inhibitors of Human Carbonic Anhydrases Implicated in Glaucoma and in Vivo Profiling of Their Intraocular Pressure-Lowering Action.Journal of medicinal chemistry, , 03-26, Volume: 63, Issue:6, 2020
[no title available]Journal of medicinal chemistry, , 01-09, Volume: 63, Issue:1, 2020
Halogenated and di-substituted benzenesulfonamides as selective inhibitors of carbonic anhydrase isoforms.European journal of medicinal chemistry, , Jan-01, Volume: 185, 2020
From random to rational: A discovery approach to selective subnanomolar inhibitors of human carbonic anhydrase IV based on the Castagnoli-Cushman multicomponent reaction.European journal of medicinal chemistry, , Nov-15, Volume: 182, 2019
Synthesis of novel tellurides bearing benzensulfonamide moiety as carbonic anhydrase inhibitors with antitumor activity.European journal of medicinal chemistry, , Nov-01, Volume: 181, 2019
[no title available]ACS medicinal chemistry letters, , Apr-11, Volume: 10, Issue:4, 2019
Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects.European journal of medicinal chemistry, , Sep-01, Volume: 177, 2019
Continued exploration and tail approach synthesis of benzenesulfonamides containing triazole and dual triazole moieties as carbonic anhydrase I, II, IV and IX inhibitors.European journal of medicinal chemistry, , Dec-01, Volume: 183, 2019
Highly hydrophilic 1,3-oxazol-5-yl benzenesulfonamide inhibitors of carbonic anhydrase II for reduction of glaucoma-related intraocular pressure.Bioorganic & medicinal chemistry, , 11-01, Volume: 27, Issue:21, 2019
Synthesis and Evaluation of Carbonic Anhydrase Inhibitors with Carbon Monoxide Releasing Properties for the Management of Rheumatoid Arthritis.Journal of medicinal chemistry, , 08-08, Volume: 62, Issue:15, 2019
Bis-benzoxaboroles: Design, Synthesis, and Biological Evaluation as Carbonic Anhydrase Inhibitors.ACS medicinal chemistry letters, , Aug-08, Volume: 10, Issue:8, 2019
Synthesis of novel 4-functionalized 1,5-diaryl-1,2,3-triazoles containing benzenesulfonamide moiety as carbonic anhydrase I, II, IV and IX inhibitors.European journal of medicinal chemistry, , Apr-25, Volume: 150, 2018
Dual-tail arylsulfone-based benzenesulfonamides differently match the hydrophobic and hydrophilic halves of human carbonic anhydrases active sites: Selective inhibitors for the tumor-associated hCA IX isoform.European journal of medicinal chemistry, , May-25, Volume: 152, 2018
Discovery of new 2, 5-disubstituted 1,3-selenazoles as selective human carbonic anhydrase IX inhibitors with potent anti-tumor activity.European journal of medicinal chemistry, , Sep-05, Volume: 157, 2018
4-Substituted Benzenesulfonamides Incorporating Bi/Tricyclic Moieties Act as Potent and Isoform-Selective Carbonic Anhydrase II/IX Inhibitors.Journal of medicinal chemistry, , 07-12, Volume: 61, Issue:13, 2018
Famotidine, an Antiulcer Agent, Strongly Inhibits ACS medicinal chemistry letters, , Oct-11, Volume: 9, Issue:10, 2018
Discovery of Novel Nonsteroidal Anti-Inflammatory Drugs and Carbonic Anhydrase Inhibitors Hybrids (NSAIDs-CAIs) for the Management of Rheumatoid Arthritis.Journal of medicinal chemistry, , 06-14, Volume: 61, Issue:11, 2018
Benzimidazole design, synthesis, and docking to build selective carbonic anhydrase VA inhibitors.Bioorganic & medicinal chemistry, , 02-01, Volume: 26, Issue:3, 2018
Design and synthesis of novel benzenesulfonamide containing 1,2,3-triazoles as potent human carbonic anhydrase isoforms I, II, IV and IX inhibitors.European journal of medicinal chemistry, , Jul-15, Volume: 155, 2018
2-Benzylpiperazine: A new scaffold for potent human carbonic anhydrase inhibitors. Synthesis, enzyme inhibition, enantioselectivity, computational and crystallographic studies and in vivo activity for a new class of intraocular pressure lowering agents.European journal of medicinal chemistry, , May-10, Volume: 151, 2018
Design and Synthesis of Novel Nonsteroidal Anti-Inflammatory Drugs and Carbonic Anhydrase Inhibitors Hybrids (NSAIDs-CAIs) for the Treatment of Rheumatoid Arthritis.Journal of medicinal chemistry, , 02-09, Volume: 60, Issue:3, 2017
Bortezomib inhibits mammalian carbonic anhydrases.Bioorganic & medicinal chemistry, , 10-01, Volume: 25, Issue:19, 2017
Human carbonic anhydrase inhibitory profile of mono- and bis-sulfonamides synthesized via a direct sulfochlorination of 3- and 4-(hetero)arylisoxazol-5-amine scaffolds.Bioorganic & medicinal chemistry, , 03-15, Volume: 25, Issue:6, 2017
Discovery of 4-sulfamoyl-phenyl-β-lactams as a new class of potent carbonic anhydrase isoforms I, II, IV and VII inhibitors: The first example of subnanomolar CA IV inhibitors.Bioorganic & medicinal chemistry, , 01-15, Volume: 25, Issue:2, 2017
Synthesis of Novel Selenides Bearing Benzenesulfonamide Moieties as Carbonic Anhydrase I, II, IV, VII, and IX Inhibitors.ACS medicinal chemistry letters, , Dec-14, Volume: 8, Issue:12, 2017
Novel indolin-2-one-based sulfonamides as carbonic anhydrase inhibitors: Synthesis, in vitro biological evaluation against carbonic anhydrases isoforms I, II, IV and VII and molecular docking studies.European journal of medicinal chemistry, , Feb-15, Volume: 127, 2017
Novel 4/3-((4-oxo-5-(2-oxoindolin-3-ylidene)thiazolidin-2-ylidene)amino) benzenesulfonamides: Synthesis, carbonic anhydrase inhibitory activity, anticancer activity and molecular modelling studies.European journal of medicinal chemistry, , Oct-20, Volume: 139, 2017
Discovery of New Selenoureido Analogues of 4-(4-Fluorophenylureido)benzenesulfonamide as Carbonic Anhydrase Inhibitors.ACS medicinal chemistry letters, , Sep-14, Volume: 8, Issue:9, 2017
Discovery of New Sulfonamide Carbonic Anhydrase IX Inhibitors Incorporating Nitrogenous Bases.ACS medicinal chemistry letters, , Dec-14, Volume: 8, Issue:12, 2017
Lucky Switcheroo: Dramatic Potency and Selectivity Improvement of Imidazoline Inhibitors of Human Carbonic Anhydrase VII.ACS medicinal chemistry letters, , Oct-12, Volume: 8, Issue:10, 2017
Evaluation of selenide, diselenide and selenoheterocycle derivatives as carbonic anhydrase I, II, IV, VII and IX inhibitors.Bioorganic & medicinal chemistry, , 04-15, Volume: 25, Issue:8, 2017
Synthesis and biological evaluation of cyclic imides incorporating benzenesulfonamide moieties as carbonic anhydrase I, II, IV and IX inhibitors.Bioorganic & medicinal chemistry, , 03-01, Volume: 25, Issue:5, 2017
Synthesis of bulky-tailed sulfonamides incorporating pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidin-1(5H)-yl) moieties and evaluation of their carbonic anhydrases I, II, IV and IX inhibitory effects.Bioorganic & medicinal chemistry, , 04-01, Volume: 25, Issue:7, 2017
Synthesis of isoxazole-containing sulfonamides with potent carbonic anhydrase II and VII inhibitory properties.Bioorganic & medicinal chemistry, , 02-15, Volume: 25, Issue:4, 2017
Microwave assisted synthesis of novel tetrazole/sulfonamide derivatives based on octahydroacridine, xanthene and chromene skeletons as inhibitors of the carbonic anhydrases isoforms I, II, IV and VII.Bioorganic & medicinal chemistry letters, , 01-01, Volume: 27, Issue:1, 2017
PEGylated Bis-Sulfonamide Carbonic Anhydrase Inhibitors Can Efficiently Control the Growth of Several Carbonic Anhydrase IX-Expressing Carcinomas.Journal of medicinal chemistry, , 05-26, Volume: 59, Issue:10, 2016
Microwave assisted synthesis of novel acridine-acetazolamide conjugates and investigation of their inhibition effects on human carbonic anhydrase isoforms hCA I, II, IV and VII.Bioorganic & medicinal chemistry, , 08-15, Volume: 24, Issue:16, 2016
Inhibition of carbonic anhydrase isoforms I, II, IV, VII and XII with carboxylates and sulfonamides incorporating phthalimide/phthalic anhydride scaffolds.Bioorganic & medicinal chemistry, , Jan-01, Volume: 24, Issue:1, 2016
An Unusual Natural Product Primary Sulfonamide: Synthesis, Carbonic Anhydrase Inhibition, and Protein X-ray Structures of Psammaplin C.Journal of medicinal chemistry, , 06-09, Volume: 59, Issue:11, 2016
Phosphate Chemical Probes Designed for Location Specific Inhibition of Intracellular Carbonic Anhydrases.Journal of medicinal chemistry, , Sep-24, Volume: 58, Issue:18, 2015
New natural product carbonic anhydrase inhibitors incorporating phenol moieties.Bioorganic & medicinal chemistry, , Nov-15, Volume: 23, Issue:22, 2015
Inhibition studies of new ureido-substituted sulfonamides incorporating a GABA moiety against human carbonic anhydrase isoforms I-XIV.Bioorganic & medicinal chemistry, , Dec-15, Volume: 22, Issue:24, 2014
Discovery and characterization of novel selective inhibitors of carbonic anhydrase IX.Journal of medicinal chemistry, , Nov-26, Volume: 57, Issue:22, 2014
Combining the tail and the ring approaches for obtaining potent and isoform-selective carbonic anhydrase inhibitors: solution and X-ray crystallographic studies.Bioorganic & medicinal chemistry, , Jan-01, Volume: 22, Issue:1, 2014
Analysis of saponins and phenolic compounds as inhibitors of α-carbonic anhydrase isoenzymes.Journal of enzyme inhibition and medicinal chemistry, , Volume: 28, Issue:2, 2013
Carbonic anhydrase inhibitors: in vitro inhibition of α isoforms (hCA I, hCA II, bCA III, hCA IV) by flavonoids.Journal of enzyme inhibition and medicinal chemistry, , Volume: 28, Issue:2, 2013
Metronidazole-coumarin conjugates and 3-cyano-7-hydroxy-coumarin act as isoform-selective carbonic anhydrase inhibitors.Journal of enzyme inhibition and medicinal chemistry, , Volume: 28, Issue:2, 2013
Simple methanesulfonates are hydrolyzed by the sulfatase carbonic anhydrase activity.Journal of enzyme inhibition and medicinal chemistry, , Volume: 27, Issue:6, 2012
Synthesis and carbonic anhydrase inhibitory properties of novel cyclohexanonyl bromophenol derivatives.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 22, Issue:3, 2012
α-Carbonic anhydrases are sulfatases with cyclic diol monosulfate esters.Journal of enzyme inhibition and medicinal chemistry, , Volume: 27, Issue:1, 2012
Synthesis and carbonic anhydrase inhibitory properties of novel bromophenols and their derivatives including natural products: vidalol B.European journal of medicinal chemistry, , Volume: 54, 2012
Structure-activity relationships for the interaction of 5,10-dihydroindeno[1,2-b]indole derivatives with human and bovine carbonic anhydrase isoforms I, II, III, IV and VI.European journal of medicinal chemistry, , Volume: 49, 2012
Sulfonamides incorporating 1,3,5-triazine moieties selectively and potently inhibit carbonic anhydrase transmembrane isoforms IX, XII and XIV over cytosolic isoforms I and II: Solution and X-ray crystallographic studies.Bioorganic & medicinal chemistry, , May-15, Volume: 19, Issue:10, 2011
Synthesis of rhodamine B-benzenesulfonamide conjugates and their inhibitory activity against human α- and bacterial/fungal β-carbonic anhydrases.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 21, Issue:18, 2011
Synthesis and crystallographic analysis of new sulfonamides incorporating NO-donating moieties with potent antiglaucoma action.Bioorganic & medicinal chemistry letters, , Jun-01, Volume: 21, Issue:11, 2011
Purification and inhibition studies with anions and sulfonamides of an α-carbonic anhydrase from the Antarctic seal Leptonychotes weddellii.Bioorganic & medicinal chemistry, , Mar-15, Volume: 19, Issue:6, 2011
Carbonic anhydrase inhibitors. The X-ray crystal structure of human isoform II in adduct with an adamantyl analogue of acetazolamide resides in a less utilized binding pocket than most hydrophobic inhibitors.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 20, Issue:15, 2010
Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule.Journal of medicinal chemistry, , Aug-12, Volume: 53, Issue:15, 2010
The coumarin-binding site in carbonic anhydrase accommodates structurally diverse inhibitors: the antiepileptic lacosamide as an example and lead molecule for novel classes of carbonic anhydrase inhibitors.Journal of medicinal chemistry, , Jan-28, Volume: 53, Issue:2, 2010
Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 20, Issue:12, 2010
A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 19, Issue:5, 2009
Carbonic anhydrase inhibitors: inhibition studies of a coral secretory isoform with inorganic anions.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 19, Issue:3, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference.Journal of medicinal chemistry, , Jan-22, Volume: 52, Issue:2, 2009
Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-binding, more isoform-selective inhibitors.Journal of medicinal chemistry, , Oct-08, Volume: 52, Issue:19, 2009
The protein tyrosine kinase inhibitors imatinib and nilotinib strongly inhibit several mammalian alpha-carbonic anhydrase isoforms.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 19, Issue:15, 2009
Carbonic anhydrase inhibitors: 2-substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes VA and VB over the cytosolic and membrane-associated carbonic anhydrases I, II and IV.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 18, Issue:24, 2008
Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-ray crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 18, Issue:15, 2008
Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid.Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008
Carbonic anhydrase inhibitors. Interaction of 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 18, Issue:3, 2008
Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors: thioxolone versus sulfonamides for obtaining isozyme-selective inhibitors?Bioorganic & medicinal chemistry letters, , Jul-15, Volume: 18, Issue:14, 2008
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors: interactions of phenols with the 12 catalytically active mammalian isoforms (CA I-XIV).Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 18, Issue:5, 2008
Carbonic anhydrase inhibitors. Inhibition of cytosolic isoforms I and II, and extracellular isoforms IV, IX, and XII with sulfamides incorporating sugar moieties.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 17, Issue:18, 2007
Carbonic anhydrases as targets for medicinal chemistry.Bioorganic & medicinal chemistry, , Jul-01, Volume: 15, Issue:13, 2007
Carbonic anhydrase inhibitors. Inhibition of isoforms I, II, IV, VA, VII, IX, and XIV with sulfonamides incorporating fructopyranose-thioureido tails.Bioorganic & medicinal chemistry letters, , May-15, Volume: 17, Issue:10, 2007
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrase inhibitors: clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue.Journal of medicinal chemistry, , Nov-30, Volume: 49, Issue:24, 2006
Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Benzolamide is not a membrane-impermeant carbonic anhydrase inhibitor.Journal of enzyme inhibition and medicinal chemistry, , Volume: 19, Issue:3, 2004
Carbonic anhydrase inhibitors: synthesis of sulfonamides incorporating dtpa tails and of their zinc complexes with powerful topical antiglaucoma properties.Bioorganic & medicinal chemistry letters, , Feb-26, Volume: 11, Issue:4, 2001
2H-Thieno[3,2-e]- and [2,3-e]-1,2-thiazine-6-sulfonamide 1,1-dioxides as ocular hypotensive agents: synthesis, carbonic anhydrase inhibition and evaluation in the rabbit.Bioorganic & medicinal chemistry, , Volume: 8, Issue:5, 2000
Acetazolamide-like carbonic anhydrase inhibitors with topical ocular hypotensive activity.Journal of medicinal chemistry, , Jul-10, Volume: 35, Issue:14, 1992
Synthesis and physicochemical properties of thiadiazolo[3,2-a]pyrimidinesulfonamides and thiadiazolo[3,2-a]triazinesulfonamides as candidates for topically effective carbonic anhydrase inhibitors.Journal of medicinal chemistry, , Volume: 30, Issue:11, 1987
N-Substituted sulfonamide carbonic anhydrase inhibitors with topical effects on intraocular pressure.Journal of medicinal chemistry, , Volume: 29, Issue:8, 1986
Recent advances in the medicinal chemistry of carbonic anhydrase inhibitors.European journal of medicinal chemistry, , Jan-01, Volume: 209, 2021
Synthesis of bulky-tailed sulfonamides incorporating pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidin-1(5H)-yl) moieties and evaluation of their carbonic anhydrases I, II, IV and IX inhibitory effects.Bioorganic & medicinal chemistry, , 04-01, Volume: 25, Issue:7, 2017
Tricyclic sulfonamides incorporating benzothiopyrano[4,3-c]pyrazole and pyridothiopyrano[4,3-c]pyrazole effectively inhibit α- and β-carbonic anhydrase: X-ray crystallography and solution investigations on 15 isoforms.Journal of medicinal chemistry, , Nov-26, Volume: 55, Issue:22, 2012
Carbonic anhydrase inhibitors. The X-ray crystal structure of human isoform II in adduct with an adamantyl analogue of acetazolamide resides in a less utilized binding pocket than most hydrophobic inhibitors.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 20, Issue:15, 2010
Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference.Journal of medicinal chemistry, , Jan-22, Volume: 52, Issue:2, 2009
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Inhibition of mammalian carbonic anhydrases I-XIV with grayanotoxin III: solution and in silico studies.Journal of enzyme inhibition and medicinal chemistry, , Volume: 29, Issue:4, 2014
Synthesis and crystallographic analysis of new sulfonamides incorporating NO-donating moieties with potent antiglaucoma action.Bioorganic & medicinal chemistry letters, , Jun-01, Volume: 21, Issue:11, 2011
Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule.Journal of medicinal chemistry, , Aug-12, Volume: 53, Issue:15, 2010
Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrases as targets for medicinal chemistry.Bioorganic & medicinal chemistry, , Jul-01, Volume: 15, Issue:13, 2007
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrase inhibitors: clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue.Journal of medicinal chemistry, , Nov-30, Volume: 49, Issue:24, 2006
Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors: in vitro inhibition of α isoforms (hCA I, hCA II, bCA III, hCA IV) by flavonoids.Journal of enzyme inhibition and medicinal chemistry, , Volume: 28, Issue:2, 2013
Synthesis and carbonic anhydrase inhibitory properties of novel cyclohexanonyl bromophenol derivatives.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 22, Issue:3, 2012
Structure-activity relationships for the interaction of 5,10-dihydroindeno[1,2-b]indole derivatives with human and bovine carbonic anhydrase isoforms I, II, III, IV and VI.European journal of medicinal chemistry, , Volume: 49, 2012
Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 20, Issue:12, 2010
A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 19, Issue:5, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference.Journal of medicinal chemistry, , Jan-22, Volume: 52, Issue:2, 2009
Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors: interactions of phenols with the 12 catalytically active mammalian isoforms (CA I-XIV).Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 18, Issue:5, 2008
Carbonic anhydrases as targets for medicinal chemistry.Bioorganic & medicinal chemistry, , Jul-01, Volume: 15, Issue:13, 2007
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrase inhibitors: clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue.Journal of medicinal chemistry, , Nov-30, Volume: 49, Issue:24, 2006
Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference.Journal of medicinal chemistry, , Jan-22, Volume: 52, Issue:2, 2009
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Benzimidazole design, synthesis, and docking to build selective carbonic anhydrase VA inhibitors.Bioorganic & medicinal chemistry, , 02-01, Volume: 26, Issue:3, 2018
Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference.Journal of medicinal chemistry, , Jan-22, Volume: 52, Issue:2, 2009
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors: synthesis of sulfonamides incorporating dtpa tails and of their zinc complexes with powerful topical antiglaucoma properties.Bioorganic & medicinal chemistry letters, , Feb-26, Volume: 11, Issue:4, 2001
A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 19, Issue:5, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference.Journal of medicinal chemistry, , Jan-22, Volume: 52, Issue:2, 2009
Carbonic anhydrase inhibitors. Interaction of 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 18, Issue:3, 2008
Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors: interactions of phenols with the 12 catalytically active mammalian isoforms (CA I-XIV).Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 18, Issue:5, 2008
Carbonic anhydrases as targets for medicinal chemistry.Bioorganic & medicinal chemistry, , Jul-01, Volume: 15, Issue:13, 2007
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrase inhibitors: clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue.Journal of medicinal chemistry, , Nov-30, Volume: 49, Issue:24, 2006
Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Benzolamide is not a membrane-impermeant carbonic anhydrase inhibitor.Journal of enzyme inhibition and medicinal chemistry, , Volume: 19, Issue:3, 2004
Carbonic anhydrase inhibitors: synthesis of sulfonamides incorporating dtpa tails and of their zinc complexes with powerful topical antiglaucoma properties.Bioorganic & medicinal chemistry letters, , Feb-26, Volume: 11, Issue:4, 2001
2H-Thieno[3,2-e]- and [2,3-e]-1,2-thiazine-6-sulfonamide 1,1-dioxides as ocular hypotensive agents: synthesis, carbonic anhydrase inhibition and evaluation in the rabbit.Bioorganic & medicinal chemistry, , Volume: 8, Issue:5, 2000
Synthesis and physicochemical properties of thiadiazolo[3,2-a]pyrimidinesulfonamides and thiadiazolo[3,2-a]triazinesulfonamides as candidates for topically effective carbonic anhydrase inhibitors.Journal of medicinal chemistry, , Volume: 30, Issue:11, 1987
Analysis of saponins and phenolic compounds as inhibitors of α-carbonic anhydrase isoenzymes.Journal of enzyme inhibition and medicinal chemistry, , Volume: 28, Issue:2, 2013
Carbonic anhydrase inhibitors: in vitro inhibition of α isoforms (hCA I, hCA II, bCA III, hCA IV) by flavonoids.Journal of enzyme inhibition and medicinal chemistry, , Volume: 28, Issue:2, 2013
Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid.Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008
[no title available]Journal of medicinal chemistry, , 01-09, Volume: 63, Issue:1, 2020
Cyclic secondary sulfonamides: unusually good inhibitors of cancer-related carbonic anhydrase enzymes.Journal of medicinal chemistry, , Apr-24, Volume: 57, Issue:8, 2014
Combining the tail and the ring approaches for obtaining potent and isoform-selective carbonic anhydrase inhibitors: solution and X-ray crystallographic studies.Bioorganic & medicinal chemistry, , Jan-01, Volume: 22, Issue:1, 2014
The coumarin-binding site in carbonic anhydrase accommodates structurally diverse inhibitors: the antiepileptic lacosamide as an example and lead molecule for novel classes of carbonic anhydrase inhibitors.Journal of medicinal chemistry, , Jan-28, Volume: 53, Issue:2, 2010
Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors: synthesis of sulfonamides incorporating dtpa tails and of their zinc complexes with powerful topical antiglaucoma properties.Bioorganic & medicinal chemistry letters, , Feb-26, Volume: 11, Issue:4, 2001
Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference.Journal of medicinal chemistry, , Jan-22, Volume: 52, Issue:2, 2009
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Substituted thieno[2,3-b]thiophenes and related congeners: Synthesis, β-glucuronidase inhibition activity, crystal structure, and POM analyses.Bioorganic & medicinal chemistry, , Dec-01, Volume: 22, Issue:23, 2014
Carbonic anhydrase inhibitors: in vitro inhibition of α isoforms (hCA I, hCA II, bCA III, hCA IV) by flavonoids.Journal of enzyme inhibition and medicinal chemistry, , Volume: 28, Issue:2, 2013
Simple methanesulfonates are hydrolyzed by the sulfatase carbonic anhydrase activity.Journal of enzyme inhibition and medicinal chemistry, , Volume: 27, Issue:6, 2012
Synthesis and carbonic anhydrase inhibitory properties of novel cyclohexanonyl bromophenol derivatives.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 22, Issue:3, 2012
Structure-activity relationships for the interaction of 5,10-dihydroindeno[1,2-b]indole derivatives with human and bovine carbonic anhydrase isoforms I, II, III, IV and VI.European journal of medicinal chemistry, , Volume: 49, 2012
The coumarin-binding site in carbonic anhydrase accommodates structurally diverse inhibitors: the antiepileptic lacosamide as an example and lead molecule for novel classes of carbonic anhydrase inhibitors.Journal of medicinal chemistry, , Jan-28, Volume: 53, Issue:2, 2010
Which carbonic anhydrases are targeted by the antiepileptic sulfonamides and sulfamates?Chemical biology & drug design, , Volume: 74, Issue:3, 2009
Carbonic anhydrase inhibitors: 2-substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes VA and VB over the cytosolic and membrane-associated carbonic anhydrases I, II and IV.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 18, Issue:24, 2008
Carbonic anhydrase inhibitors. Interaction of 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 18, Issue:3, 2008
Carbonic anhydrase inhibitors. Interaction of the antiepileptic drug sulthiame with twelve mammalian isoforms: kinetic and X-ray crystallographic studies.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 17, Issue:17, 2007
Characterization and anions inhibition studies of an α-carbonic anhydrase from the teleost fish Dicentrarchus labrax.Bioorganic & medicinal chemistry, , Jan-15, Volume: 19, Issue:2, 2011
Carbonic anhydrase inhibitors: the membrane-associated isoform XV is highly inhibited by inorganic anions.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 19, Issue:4, 2009
Carbonic anhydrase inhibitors: inhibition studies of a coral secretory isoform with inorganic anions.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 19, Issue:3, 2009
Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V, and IX with anions isosteric and isoelectronic with sulfate, nitrate, and carbonate.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 15, Issue:3, 2005
Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Carbonic anhydrase activators. Activation of the membrane-associated isoform XV with amino acids and amines.Bioorganic & medicinal chemistry letters, , Jul-01, Volume: 19, Issue:13, 2009
Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 18, Issue:15, 2008
Carbonic anhydrase activators. Activation of the membrane-associated isoform XV with amino acids and amines.Bioorganic & medicinal chemistry letters, , Jul-01, Volume: 19, Issue:13, 2009
Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 18, Issue:15, 2008
Binding site comparison for coumarin inhibitors and amine/amino acid activators of human carbonic anhydrases.European journal of medicinal chemistry, , Dec-15, Volume: 226, 2021
Carbonic anhydrase activators. Activation of the membrane-associated isoform XV with amino acids and amines.Bioorganic & medicinal chemistry letters, , Jul-01, Volume: 19, Issue:13, 2009
Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 18, Issue:15, 2008
Carbonic anhydrase activators: X-ray crystal structure of the adduct of human isozyme II with L-histidine as a platform for the design of stronger activators.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 15, Issue:23, 2005
Binding site comparison for coumarin inhibitors and amine/amino acid activators of human carbonic anhydrases.European journal of medicinal chemistry, , Dec-15, Volume: 226, 2021
Carbonic anhydrase activators. Activation of the membrane-associated isoform XV with amino acids and amines.Bioorganic & medicinal chemistry letters, , Jul-01, Volume: 19, Issue:13, 2009
Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 18, Issue:15, 2008
Carbonic anhydrase activators: X-ray crystal structure of the adduct of human isozyme II with L-histidine as a platform for the design of stronger activators.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 15, Issue:23, 2005
Carbonic anhydrase activators. Activation of the membrane-associated isoform XV with amino acids and amines.Bioorganic & medicinal chemistry letters, , Jul-01, Volume: 19, Issue:13, 2009
Carbonic anhydrase activators: kinetic and X-ray crystallographic study for the interaction of D- and L-tryptophan with the mammalian isoforms I-XIV.Bioorganic & medicinal chemistry, , Sep-15, Volume: 16, Issue:18, 2008
Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 18, Issue:15, 2008
Synthesis and carbonic anhydrase inhibitory properties of novel cyclohexanonyl bromophenol derivatives.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 22, Issue:3, 2012
Structure-activity relationships for the interaction of 5,10-dihydroindeno[1,2-b]indole derivatives with human and bovine carbonic anhydrase isoforms I, II, III, IV and VI.European journal of medicinal chemistry, , Volume: 49, 2012
Carbonic anhydrase inhibitors: the membrane-associated isoform XV is highly inhibited by inorganic anions.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 19, Issue:4, 2009
Carbonic anhydrase inhibitors: inhibition studies of a coral secretory isoform with inorganic anions.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 19, Issue:3, 2009
Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Synthesis and carbonic anhydrase inhibitory properties of novel cyclohexanonyl bromophenol derivatives.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 22, Issue:3, 2012
Sulfonylmethanesulfonamide inhibitors of carbonic anhydrase.Journal of medicinal chemistry, , Jul-23, Volume: 36, Issue:15, 1993
Carbonic anhydrase activators. Activation of the membrane-associated isoform XV with amino acids and amines.Bioorganic & medicinal chemistry letters, , Jul-01, Volume: 19, Issue:13, 2009
Sildenafil is a strong activator of mammalian carbonic anhydrase isoforms I-XIV.Bioorganic & medicinal chemistry, , Aug-15, Volume: 17, Issue:16, 2009
Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 18, Issue:15, 2008
Binding site comparison for coumarin inhibitors and amine/amino acid activators of human carbonic anhydrases.European journal of medicinal chemistry, , Dec-15, Volume: 226, 2021
Carbonic anhydrase activators. Activation of the membrane-associated isoform XV with amino acids and amines.Bioorganic & medicinal chemistry letters, , Jul-01, Volume: 19, Issue:13, 2009
Carbonic anhydrase activators: kinetic and X-ray crystallographic study for the interaction of D- and L-tryptophan with the mammalian isoforms I-XIV.Bioorganic & medicinal chemistry, , Sep-15, Volume: 16, Issue:18, 2008
Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 18, Issue:15, 2008
Analysis of saponins and phenolic compounds as inhibitors of α-carbonic anhydrase isoenzymes.Journal of enzyme inhibition and medicinal chemistry, , Volume: 28, Issue:2, 2013
Carbonic anhydrase inhibitors: in vitro inhibition of α isoforms (hCA I, hCA II, bCA III, hCA IV) by flavonoids.Journal of enzyme inhibition and medicinal chemistry, , Volume: 28, Issue:2, 2013
Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with phosphates, carbamoyl phosphate, and the phosphonate antiviral drug foscarnet.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Carbonic anhydrase activators. Activation of the membrane-associated isoform XV with amino acids and amines.Bioorganic & medicinal chemistry letters, , Jul-01, Volume: 19, Issue:13, 2009
Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 18, Issue:15, 2008
Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V, and IX with anions isosteric and isoelectronic with sulfate, nitrate, and carbonate.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 15, Issue:3, 2005
Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with phosphates, carbamoyl phosphate, and the phosphonate antiviral drug foscarnet.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V, and IX with anions isosteric and isoelectronic with sulfate, nitrate, and carbonate.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 15, Issue:3, 2005
Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V, and IX with anions isosteric and isoelectronic with sulfate, nitrate, and carbonate.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 15, Issue:3, 2005
Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V, and IX with anions isosteric and isoelectronic with sulfate, nitrate, and carbonate.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 15, Issue:3, 2005
Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the methanoarchaeon Methanobacterium thermoautotrophicum (Cab) with anions.Bioorganic & medicinal chemistry letters, , Sep-06, Volume: 14, Issue:17, 2004
Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Phosph(on)ate as a zinc-binding group in metalloenzyme inhibitors: X-ray crystal structure of the antiviral drug foscarnet complexed to human carbonic anhydrase I.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 17, Issue:8, 2007
Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with phosphates, carbamoyl phosphate, and the phosphonate antiviral drug foscarnet.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V, and IX with anions isosteric and isoelectronic with sulfate, nitrate, and carbonate.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 15, Issue:3, 2005
Bortezomib inhibits mammalian carbonic anhydrases.Bioorganic & medicinal chemistry, , 10-01, Volume: 25, Issue:19, 2017
Carbonic anhydrase inhibitors: inhibition studies of a coral secretory isoform with inorganic anions.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 19, Issue:3, 2009
Carbonic anhydrase inhibitors: the membrane-associated isoform XV is highly inhibited by inorganic anions.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 19, Issue:4, 2009
Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors: synthesis of sulfonamides incorporating dtpa tails and of their zinc complexes with powerful topical antiglaucoma properties.Bioorganic & medicinal chemistry letters, , Feb-26, Volume: 11, Issue:4, 2001
Discovery of Potent Dual-Tailed Benzenesulfonamide Inhibitors of Human Carbonic Anhydrases Implicated in Glaucoma and in Vivo Profiling of Their Intraocular Pressure-Lowering Action.Journal of medicinal chemistry, , 03-26, Volume: 63, Issue:6, 2020
Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors. Interaction of the antiepileptic drug sulthiame with twelve mammalian isoforms: kinetic and X-ray crystallographic studies.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 17, Issue:17, 2007
Structural aspects of isozyme selectivity in the binding of inhibitors to carbonic anhydrases II and IV.Journal of medicinal chemistry, , Feb-14, Volume: 45, Issue:4, 2002
2H-Thieno[3,2-e]- and [2,3-e]-1,2-thiazine-6-sulfonamide 1,1-dioxides as ocular hypotensive agents: synthesis, carbonic anhydrase inhibition and evaluation in the rabbit.Bioorganic & medicinal chemistry, , Volume: 8, Issue:5, 2000
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Binding site comparison for coumarin inhibitors and amine/amino acid activators of human carbonic anhydrases.European journal of medicinal chemistry, , Dec-15, Volume: 226, 2021
Carbonic anhydrase activators. Activation of the membrane-associated isoform XV with amino acids and amines.Bioorganic & medicinal chemistry letters, , Jul-01, Volume: 19, Issue:13, 2009
Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 18, Issue:15, 2008
Binding site comparison for coumarin inhibitors and amine/amino acid activators of human carbonic anhydrases.European journal of medicinal chemistry, , Dec-15, Volume: 226, 2021
Carbonic anhydrase activators. Activation of the membrane-associated isoform XV with amino acids and amines.Bioorganic & medicinal chemistry letters, , Jul-01, Volume: 19, Issue:13, 2009
Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 18, Issue:15, 2008
Carbonic anhydrase activators. Activation of the membrane-associated isoform XV with amino acids and amines.Bioorganic & medicinal chemistry letters, , Jul-01, Volume: 19, Issue:13, 2009
Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 18, Issue:15, 2008
Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 20, Issue:12, 2010
Carbonic anhydrase inhibitors: inhibition studies of a coral secretory isoform with inorganic anions.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 19, Issue:3, 2009
Carbonic anhydrase inhibitors: the membrane-associated isoform XV is highly inhibited by inorganic anions.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 19, Issue:4, 2009
Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V, and IX with anions isosteric and isoelectronic with sulfate, nitrate, and carbonate.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 15, Issue:3, 2005
Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Carbonic anhydrase inhibitors. The X-ray crystal structure of human isoform II in adduct with an adamantyl analogue of acetazolamide resides in a less utilized binding pocket than most hydrophobic inhibitors.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 20, Issue:15, 2010
Carbonic anhydrase inhibitors. Interaction of 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 18, Issue:3, 2008
Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors: synthesis of sulfonamides incorporating dtpa tails and of their zinc complexes with powerful topical antiglaucoma properties.Bioorganic & medicinal chemistry letters, , Feb-26, Volume: 11, Issue:4, 2001
Carbonic anhydrase activators. Activation of the membrane-associated isoform XV with amino acids and amines.Bioorganic & medicinal chemistry letters, , Jul-01, Volume: 19, Issue:13, 2009
Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 18, Issue:15, 2008
Recent advances in the medicinal chemistry of carbonic anhydrase inhibitors.European journal of medicinal chemistry, , Jan-01, Volume: 209, 2021
Tricyclic sulfonamides incorporating benzothiopyrano[4,3-c]pyrazole and pyridothiopyrano[4,3-c]pyrazole effectively inhibit α- and β-carbonic anhydrase: X-ray crystallography and solution investigations on 15 isoforms.Journal of medicinal chemistry, , Nov-26, Volume: 55, Issue:22, 2012
Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase activators. Activation of the membrane-associated isoform XV with amino acids and amines.Bioorganic & medicinal chemistry letters, , Jul-01, Volume: 19, Issue:13, 2009
Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 18, Issue:15, 2008
Novel indolin-2-one-based sulfonamides as carbonic anhydrase inhibitors: Synthesis, in vitro biological evaluation against carbonic anhydrases isoforms I, II, IV and VII and molecular docking studies.European journal of medicinal chemistry, , Feb-15, Volume: 127, 2017
Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors: synthesis of sulfonamides incorporating dtpa tails and of their zinc complexes with powerful topical antiglaucoma properties.Bioorganic & medicinal chemistry letters, , Feb-26, Volume: 11, Issue:4, 2001
Carbonic anhydrase activators. Activation of the membrane-associated isoform XV with amino acids and amines.Bioorganic & medicinal chemistry letters, , Jul-01, Volume: 19, Issue:13, 2009
Carbonic anhydrase activators: kinetic and X-ray crystallographic study for the interaction of D- and L-tryptophan with the mammalian isoforms I-XIV.Bioorganic & medicinal chemistry, , Sep-15, Volume: 16, Issue:18, 2008
Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 18, Issue:15, 2008
[no title available]Journal of medicinal chemistry, , 01-09, Volume: 63, Issue:1, 2020
Discovery of New Selenoureido Analogues of 4-(4-Fluorophenylureido)benzenesulfonamide as Carbonic Anhydrase Inhibitors.ACS medicinal chemistry letters, , Sep-14, Volume: 8, Issue:9, 2017
Carbonic anhydrase activators. Activation of the membrane-associated isoform XV with amino acids and amines.Bioorganic & medicinal chemistry letters, , Jul-01, Volume: 19, Issue:13, 2009
Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 18, Issue:15, 2008
Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with carboxylates.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 15, Issue:3, 2005
Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with phosphates, carbamoyl phosphate, and the phosphonate antiviral drug foscarnet.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with carboxylates.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 15, Issue:3, 2005
Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with phosphates, carbamoyl phosphate, and the phosphonate antiviral drug foscarnet.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Analysis of saponins and phenolic compounds as inhibitors of α-carbonic anhydrase isoenzymes.Journal of enzyme inhibition and medicinal chemistry, , Volume: 28, Issue:2, 2013
Carbonic anhydrase inhibitors: in vitro inhibition of α isoforms (hCA I, hCA II, bCA III, hCA IV) by flavonoids.Journal of enzyme inhibition and medicinal chemistry, , Volume: 28, Issue:2, 2013
Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
New natural product carbonic anhydrase inhibitors incorporating phenol moieties.Bioorganic & medicinal chemistry, , Nov-15, Volume: 23, Issue:22, 2015
Carbonic anhydrase inhibitors: in vitro inhibition of α isoforms (hCA I, hCA II, bCA III, hCA IV) by flavonoids.Journal of enzyme inhibition and medicinal chemistry, , Volume: 28, Issue:2, 2013
Discovery of Potent Dual-Tailed Benzenesulfonamide Inhibitors of Human Carbonic Anhydrases Implicated in Glaucoma and in Vivo Profiling of Their Intraocular Pressure-Lowering Action.Journal of medicinal chemistry, , 03-26, Volume: 63, Issue:6, 2020
Synthesis and crystallographic analysis of new sulfonamides incorporating NO-donating moieties with potent antiglaucoma action.Bioorganic & medicinal chemistry letters, , Jun-01, Volume: 21, Issue:11, 2011
Thioether benzenesulfonamide inhibitors of carbonic anhydrases II and IV: structure-based drug design, synthesis, and biological evaluation.Bioorganic & medicinal chemistry, , May-01, Volume: 18, Issue:9, 2010
Nitric oxide-donating carbonic anhydrase inhibitors for the treatment of open-angle glaucoma.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 19, Issue:23, 2009
Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-binding, more isoform-selective inhibitors.Journal of medicinal chemistry, , Oct-08, Volume: 52, Issue:19, 2009
Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrases as targets for medicinal chemistry.Bioorganic & medicinal chemistry, , Jul-01, Volume: 15, Issue:13, 2007
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrase inhibitors: clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue.Journal of medicinal chemistry, , Nov-30, Volume: 49, Issue:24, 2006
Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors: synthesis of sulfonamides incorporating dtpa tails and of their zinc complexes with powerful topical antiglaucoma properties.Bioorganic & medicinal chemistry letters, , Feb-26, Volume: 11, Issue:4, 2001
2H-Thieno[3,2-e]- and [2,3-e]-1,2-thiazine-6-sulfonamide 1,1-dioxides as ocular hypotensive agents: synthesis, carbonic anhydrase inhibition and evaluation in the rabbit.Bioorganic & medicinal chemistry, , Volume: 8, Issue:5, 2000
The coumarin-binding site in carbonic anhydrase accommodates structurally diverse inhibitors: the antiepileptic lacosamide as an example and lead molecule for novel classes of carbonic anhydrase inhibitors.Journal of medicinal chemistry, , Jan-28, Volume: 53, Issue:2, 2010
Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 20, Issue:12, 2010
Carbonic anhydrase inhibitors: 2-substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes VA and VB over the cytosolic and membrane-associated carbonic anhydrases I, II and IV.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 18, Issue:24, 2008
Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-ray crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 18, Issue:15, 2008
Carbonic anhydrase inhibitors. Inhibition of cytosolic isoforms I and II, and extracellular isoforms IV, IX, and XII with sulfamides incorporating sugar moieties.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 17, Issue:18, 2007
Carbonic anhydrases as targets for medicinal chemistry.Bioorganic & medicinal chemistry, , Jul-01, Volume: 15, Issue:13, 2007
Carbonic anhydrase inhibitors. Inhibition of isoforms I, II, IV, VA, VII, IX, and XIV with sulfonamides incorporating fructopyranose-thioureido tails.Bioorganic & medicinal chemistry letters, , May-15, Volume: 17, Issue:10, 2007
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrase inhibitors: clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue.Journal of medicinal chemistry, , Nov-30, Volume: 49, Issue:24, 2006
Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Enables
This protein enables 3 target(s):
| Target | Category | Definition |
|---|
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| zinc ion binding | molecular function | Binding to a zinc ion (Zn). [GOC:ai] |
| carbonate dehydratase activity | molecular function | Catalysis of the reaction: hydrogencarbonate + H+ = CO2 + H2O. [EC:4.2.1.1] |
Located In
This protein is located in 14 target(s):
| Target | Category | Definition |
|---|
| rough endoplasmic reticulum | cellular component | The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae. [ISBN:0198506732] |
| endoplasmic reticulum-Golgi intermediate compartment | cellular component | A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi and Golgi-to-ER transport. [GOC:pr, PMID:16723730] |
| Golgi apparatus | cellular component | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. [ISBN:0198506732] |
| trans-Golgi network | cellular component | The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination. [GOC:vw, ISBN:0815316194] |
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| external side of plasma membrane | cellular component | The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface. [GOC:dos, GOC:tb] |
| cell surface | cellular component | The external part of the cell wall and/or plasma membrane. [GOC:jl, GOC:mtg_sensu, GOC:sm] |
| membrane | cellular component | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
| apical plasma membrane | cellular component | The region of the plasma membrane located at the apical end of the cell. [GOC:curators] |
| transport vesicle membrane | cellular component | The lipid bilayer surrounding a transport vesicle. [GOC:mah] |
| secretory granule membrane | cellular component | The lipid bilayer surrounding a secretory granule. [GOC:mah] |
| brush border membrane | cellular component | The portion of the plasma membrane surrounding the brush border. [GOC:mah] |
| perinuclear region of cytoplasm | cellular component | Cytoplasm situated near, or occurring around, the nucleus. [GOC:jid] |
| extracellular exosome | cellular component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
Active In
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
Involved In
This protein is involved in 2 target(s):
| Target | Category | Definition |
|---|
| bicarbonate transport | biological process | The directed movement of bicarbonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc] |
| one-carbon metabolic process | biological process | The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. [GOC:hjd, GOC:mah, GOC:pde] |