Proteins > Protein mono-ADP-ribosyltransferase PARP12
Page last updated: 2024-08-07 21:20:39
Protein mono-ADP-ribosyltransferase PARP12
A protein mono-ADP-ribosyltransferase PARP12 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H0J9]
Synonyms
EC 2.4.2.-;
ADP-ribosyltransferase diphtheria toxin-like 12;
ARTD12;
Poly [ADP-ribose] polymerase 12;
PARP-12;
Zinc finger CCCH domain-containing protein 1
Research
Bioassay Publications (3)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
Compounds (7)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| pj-34 | Homo sapiens (human) | IC50 | 0.2269 | 1 | 2 |
| 4-Methoxybenzamide | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| rucaparib | Homo sapiens (human) | IC50 | 6.6285 | 1 | 2 |
| veliparib | Homo sapiens (human) | IC50 | 59.1422 | 1 | 2 |
| olaparib | Homo sapiens (human) | IC50 | 10.1415 | 1 | 2 |
| niraparib | Homo sapiens (human) | IC50 | 0.4367 | 1 | 2 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| rucaparib | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| niraparib | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| bmn 673 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
Discovery of 5-{4-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}-Journal of medicinal chemistry, , 10-14, Volume: 64, Issue:19, 2021
Structural Basis for Potency and Promiscuity in Poly(ADP-ribose) Polymerase (PARP) and Tankyrase Inhibitors.Journal of medicinal chemistry, , 02-23, Volume: 60, Issue:4, 2017
Discovery of 5-{4-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}-Journal of medicinal chemistry, , 10-14, Volume: 64, Issue:19, 2021
Structural Basis for Potency and Promiscuity in Poly(ADP-ribose) Polymerase (PARP) and Tankyrase Inhibitors.Journal of medicinal chemistry, , 02-23, Volume: 60, Issue:4, 2017
Enables
This protein enables 6 target(s):
| Target | Category | Definition |
|---|
| RNA binding | molecular function | Binding to an RNA molecule or a portion thereof. [GOC:jl, GOC:mah] |
| nucleotidyltransferase activity | molecular function | Catalysis of the transfer of a nucleotidyl group to a reactant. [ISBN:0198506732] |
| metal ion binding | molecular function | Binding to a metal ion. [GOC:ai] |
| NAD+- protein-cysteine ADP-ribosyltransferase activity | molecular function | Catalysis of the reaction: L-cysteinyl-[protein] + NAD+ = H+ + nicotinamide + S-(ADP-D-ribosyl)-L-cysteinyl-[protein]. [PMID:25043379, RHEA:56612] |
| NAD+-protein ADP-ribosyltransferase activity | molecular function | Catalysis of the reaction: amino acyl-[protein] + NAD+ = H+ + (ADP-D-ribosyl)-amino acyl-[protein] + nicotinamide. [PMID:1899243] |
| NAD+ ADP-ribosyltransferase activity | molecular function | Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor. [EC:2.4.2.30] |
Active In
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|
| nucleus | cellular component | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators] |
Involved In
This protein is involved in 1 target(s):
| Target | Category | Definition |
|---|
| protein auto-ADP-ribosylation | biological process | The ADP-ribosylation by a protein of one or more of its own amino acid residues, or residues on an identical protein. [GOC:BHF, GOC:rl] |