Page last updated: 2024-11-07

aldosterone and Necrosis

aldosterone has been researched along with Necrosis in 22 studies

Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.

Research Excerpts

ExcerptRelevanceReference
" Administration of angiotensin II and Nomega-nitro-L-arginine methyl ester (L-NAME; nitric oxide synthesis inhibitor) to male rats drinking 1% saline caused hypertension, severe biventricular myocardial necrosis, proteinuria, and fibrinoid necrosis of renal and cardiac vessels."7.70Aldosterone: a mediator of myocardial necrosis and renal arteriopathy. ( Adler, GK; Kifor, I; Ochoa-Maya, MR; Rennke, HG; Rocha, R; Stier, CT; Williams, GH, 2000)
"Heart failure is a major cause of cardiovascular morbidity and mortality and its incidence is on the increase."6.43Neurohormones and heart failure: the importance of aldosterone. ( Ferro, A; Odedra, K, 2006)
"Felodipine has a protective effect on the myocardium and kidney as evidenced by decreased perivascular inflammation, myocardial necrosis and fibrosis."5.36Effect of felodipine on myocardial and renal injury induced by aldosterone-high salt hypertension in uninephrectomized rats. ( Franco, M; Janicki, JS; Matsubara, BB; Matsubara, LS, 2010)
"The reactive fibrosis is thought to be related to MC excess, while cell loss and microscopic scarring may be secondary to enhanced potassium excretion or a cytotoxic effect of aldosterone."5.29Myocardial fibrosis in the rat with mineralocorticoid excess. Prevention of scarring by amiloride. ( Campbell, SE; Janicki, JS; Matsubara, BB; Weber, KT, 1993)
" Administration of angiotensin II and Nomega-nitro-L-arginine methyl ester (L-NAME; nitric oxide synthesis inhibitor) to male rats drinking 1% saline caused hypertension, severe biventricular myocardial necrosis, proteinuria, and fibrinoid necrosis of renal and cardiac vessels."3.70Aldosterone: a mediator of myocardial necrosis and renal arteriopathy. ( Adler, GK; Kifor, I; Ochoa-Maya, MR; Rennke, HG; Rocha, R; Stier, CT; Williams, GH, 2000)
"Fibrosis is a fundamental component of the adverse structural remodeling of myocardium present in the failing heart."2.47Cellular and molecular pathways to myocardial necrosis and replacement fibrosis. ( Ahokas, RA; Bhattacharya, SK; Gandhi, MS; Gerling, IC; Kamalov, G; Shahbaz, AU; Sun, Y; Weber, KT, 2011)
"Heart failure is a major cause of cardiovascular morbidity and mortality and its incidence is on the increase."2.43Neurohormones and heart failure: the importance of aldosterone. ( Ferro, A; Odedra, K, 2006)
"Aldosterone has several deleterious properties."2.41Aldosterone: cardiovascular assault. ( Struthers, AD, 2002)
"Reactive fibrosis is associated with elevations in plasma aldosterone concentrations that are inappropriate relative to dietary sodium intake."2.38Factors associated with reactive and reparative fibrosis of the myocardium. ( Brilla, CG; Weber, KT, 1992)
"Felodipine has a protective effect on the myocardium and kidney as evidenced by decreased perivascular inflammation, myocardial necrosis and fibrosis."1.36Effect of felodipine on myocardial and renal injury induced by aldosterone-high salt hypertension in uninephrectomized rats. ( Franco, M; Janicki, JS; Matsubara, BB; Matsubara, LS, 2010)
"The reactive fibrosis is thought to be related to MC excess, while cell loss and microscopic scarring may be secondary to enhanced potassium excretion or a cytotoxic effect of aldosterone."1.29Myocardial fibrosis in the rat with mineralocorticoid excess. Prevention of scarring by amiloride. ( Campbell, SE; Janicki, JS; Matsubara, BB; Weber, KT, 1993)

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-19906 (27.27)18.7374
1990's3 (13.64)18.2507
2000's6 (27.27)29.6817
2010's7 (31.82)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Khan, MU1
Zhao, W3
Zhao, T2
Al Darazi, F1
Ahokas, RA5
Sun, Y5
Bhattacharya, SK5
Gerling, IC5
Weber, KT8
Gandhi, MS2
Deshmukh, PA1
Kamalov, G4
Whaley, JT1
Tichy, JR1
Shahbaz, AU2
Matsubara, BB2
Franco, M1
Janicki, JS2
Matsubara, LS1
Zia, AA1
Newman, KP1
McGee, JE1
Ferron, L1
Ruchon, Y1
Renaud, JF1
Capuano, V1
Todkar, A1
Di Chiara, M1
Loffing-Cueni, D1
Bettoni, C1
Mohaupt, M1
Loffing, J1
Wagner, CA1
Struthers, AD1
Rocha, R2
Martin-Berger, CL1
Yang, P1
Scherrer, R1
Delyani, J1
McMahon, E1
WEXLER, BC1
KITTINGER, GW1
SELYE, H1
Odedra, K1
Ferro, A1
Fazekas, AG1
Kókai, K1
Kovács, K1
Robert, V1
Silvestre, JS1
Charlemagne, D1
Sabri, A1
Trouvé, P1
Wassef, M1
Swynghedauw, B1
Delcayre, C1
Campbell, SE1
Stier, CT1
Kifor, I1
Ochoa-Maya, MR1
Rennke, HG1
Williams, GH1
Adler, GK1
Severson, JA1
Fell, RD1
Griffith, DR1
Brilla, CG1
Castleman, B1
Scully, RE1
McNeely, BU1
Fisher, CE1
Turner, FA1
Horton, R1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Randomised Open Label, Blinded End Point Trial to Compare the Effects of Spironolactone With Chlortalidone on LV Mass in Stage 3 Chronic Kidney Disease (SPIRO-CKD)[NCT02502981]Phase 4154 participants (Actual)Interventional2014-06-30Active, not recruiting
Is Spironolactone Safe and Effective in the Treatment of Cardiovascular Disease in Mild Chronic Renal Failure?[NCT00291720]Phase 2120 participants (Actual)Interventional2005-04-30Completed
Mineralocorticoid Receptor, Coronary Microvascular Function, and Cardiac Efficiency in Hypertension[NCT05593055]Phase 475 participants (Anticipated)Interventional2023-08-25Recruiting
Usefulness of Spironolactone for the Prevention of Acute Kidney Injury in Critically Ill Patients With Invasive Mechanical Ventilation[NCT03206658]Phase 390 participants (Anticipated)Interventional2017-08-01Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

5 reviews available for aldosterone and Necrosis

ArticleYear
Cellular and molecular pathways to myocardial necrosis and replacement fibrosis.
    Heart failure reviews, 2011, Volume: 16, Issue:1

    Topics: Aldosterone; Animals; Disease Models, Animal; Fibrosis; Heart Failure; Humans; Hypercalciuria; Hyper

2011
From aldosteronism to oxidative stress: the role of excessive intracellular calcium accumulation.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2010, Volume: 33, Issue:11

    Topics: Aldosterone; Animals; Calcium; Coronary Vessels; Disease Models, Animal; Hyperaldosteronism; Myocard

2010
Aldosterone: cardiovascular assault.
    American heart journal, 2002, Volume: 144, Issue:5 Suppl

    Topics: Aldosterone; Autonomic Nervous System Diseases; Cardiomegaly; Endothelium, Vascular; Fibrinolysis; F

2002
Neurohormones and heart failure: the importance of aldosterone.
    International journal of clinical practice, 2006, Volume: 60, Issue:7

    Topics: Adaptation, Physiological; Aldosterone; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Convert

2006
Factors associated with reactive and reparative fibrosis of the myocardium.
    Basic research in cardiology, 1992, Volume: 87 Suppl 1

    Topics: Aldosterone; Animals; Cardiomyopathies; Fibroblasts; Fibrosis; Humans; Myocardium; Necrosis; Wound H

1992

Other Studies

17 other studies available for aldosterone and Necrosis

ArticleYear
Nebivolol: a multifaceted antioxidant and cardioprotectant in hypertensive heart disease.
    Journal of cardiovascular pharmacology, 2013, Volume: 62, Issue:5

    Topics: Aldosterone; Animals; Antioxidants; Benzopyrans; Calcium; Cardiotonic Agents; Cytosol; Disease Model

2013
Causes and consequences of zinc dyshomeostasis in rats with chronic aldosteronism.
    Journal of cardiovascular pharmacology, 2008, Volume: 52, Issue:3

    Topics: Acetazolamide; Aldosterone; Animals; Calcium; Chronic Disease; Disease Models, Animal; Homeostasis;

2008
Temporal responses to intrinsically coupled calcium and zinc dyshomeostasis in cardiac myocytes and mitochondria during aldosteronism.
    American journal of physiology. Heart and circulatory physiology, 2010, Volume: 298, Issue:2

    Topics: Aldosterone; Animals; Calcium; Dinoprost; Disease Models, Animal; Glutathione Peroxidase; Homeostasi

2010
Effect of felodipine on myocardial and renal injury induced by aldosterone-high salt hypertension in uninephrectomized rats.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2010, Volume: 43, Issue:5

    Topics: Aldosterone; Animals; Blood Pressure; Calcium Channel Blockers; Disease Models, Animal; Felodipine;

2010
T-type Ca²+ signalling regulates aldosterone-induced CREB activation and cell death through PP2A activation in neonatal cardiomyocytes.
    Cardiovascular research, 2011, Apr-01, Volume: 90, Issue:1

    Topics: Aldosterone; Animals; Animals, Newborn; Apoptosis; bcl-X Protein; Calcium Channels, T-Type; Calcium

2011
Aldosterone deficiency adversely affects pregnancy outcome in mice.
    Pflugers Archiv : European journal of physiology, 2012, Volume: 464, Issue:4

    Topics: Aldosterone; Animals; Blood Pressure; Cytochrome P-450 CYP11B2; Diet; Disease Models, Animal; Female

2012
Selective aldosterone blockade prevents angiotensin II/salt-induced vascular inflammation in the rat heart.
    Endocrinology, 2002, Volume: 143, Issue:12

    Topics: Adrenalectomy; Aldosterone; Angiotensin II; Animals; Body Weight; Coronary Disease; Coronary Vessels

2002
STEROIDS PRODUCED IN VITRO BY ADRENAL GLANDS OF NORMAL AND ARTERIOSCLEROTIC RATS DURING AND AFTER DRUG-INDUCED MYOCARDIAL NECROSIS.
    Circulation research, 1965, Volume: 16

    Topics: Adrenal Cortex Hormones; Adrenal Glands; Aldosterone; Arteriosclerosis; Heart Failure; In Vitro Tech

1965
Protection by a steroid-spirolactone against certain types of cardiac necroses.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1960, Volume: 104

    Topics: Aldosterone; Heart; Humans; Mineralocorticoid Receptor Antagonists; Myocardium; Necrosis; Spironolac

1960
From inflammation to fibrosis: a stiff stretch of highway.
    Hypertension (Dallas, Tex. : 1979), 2004, Volume: 43, Issue:4

    Topics: Aldosterone; Angiotensin II; Animals; Aorta, Abdominal; Apoptosis; Cell Adhesion Molecules; Collagen

2004
Effect of hexadimethrine bromide on the conversion of 4-14C-progesterone into aldosterone and corticosterone by rat adrenals.
    Steroids, 1967, Volume: 9, Issue:5

    Topics: Adrenal Glands; Aldosterone; Animals; Carbon Isotopes; Chromatography; Chromatography, Thin Layer; C

1967
Biological determinants of aldosterone-induced cardiac fibrosis in rats.
    Hypertension (Dallas, Tex. : 1979), 1995, Volume: 26, Issue:6 Pt 1

    Topics: Aldosterone; Animals; Blotting, Northern; Collagen; Fibrosis; Heart; Histocytochemistry; Hypertensio

1995
Myocardial fibrosis in the rat with mineralocorticoid excess. Prevention of scarring by amiloride.
    American journal of hypertension, 1993, Volume: 6, Issue:6 Pt 1

    Topics: Aldosterone; Amiloride; Animals; Cardiomyopathies; Cicatrix; Collagen; Disease Models, Animal; Drug

1993
Aldosterone: a mediator of myocardial necrosis and renal arteriopathy.
    Endocrinology, 2000, Volume: 141, Issue:10

    Topics: Adrenalectomy; Aldosterone; Angiotensin II; Animals; Blood Pressure; Cardiomyopathies; Enzyme Inhibi

2000
Aldosterone: a mediator of myocardial necrosis and renal arteriopathy.
    Endocrinology, 2000, Volume: 141, Issue:10

    Topics: Adrenalectomy; Aldosterone; Angiotensin II; Animals; Blood Pressure; Cardiomyopathies; Enzyme Inhibi

2000
Aldosterone: a mediator of myocardial necrosis and renal arteriopathy.
    Endocrinology, 2000, Volume: 141, Issue:10

    Topics: Adrenalectomy; Aldosterone; Angiotensin II; Animals; Blood Pressure; Cardiomyopathies; Enzyme Inhibi

2000
Aldosterone: a mediator of myocardial necrosis and renal arteriopathy.
    Endocrinology, 2000, Volume: 141, Issue:10

    Topics: Adrenalectomy; Aldosterone; Angiotensin II; Animals; Blood Pressure; Cardiomyopathies; Enzyme Inhibi

2000
Aldosterone: a mediator of myocardial necrosis and renal arteriopathy.
    Endocrinology, 2000, Volume: 141, Issue:10

    Topics: Adrenalectomy; Aldosterone; Angiotensin II; Animals; Blood Pressure; Cardiomyopathies; Enzyme Inhibi

2000
Aldosterone: a mediator of myocardial necrosis and renal arteriopathy.
    Endocrinology, 2000, Volume: 141, Issue:10

    Topics: Adrenalectomy; Aldosterone; Angiotensin II; Animals; Blood Pressure; Cardiomyopathies; Enzyme Inhibi

2000
Aldosterone: a mediator of myocardial necrosis and renal arteriopathy.
    Endocrinology, 2000, Volume: 141, Issue:10

    Topics: Adrenalectomy; Aldosterone; Angiotensin II; Animals; Blood Pressure; Cardiomyopathies; Enzyme Inhibi

2000
Aldosterone: a mediator of myocardial necrosis and renal arteriopathy.
    Endocrinology, 2000, Volume: 141, Issue:10

    Topics: Adrenalectomy; Aldosterone; Angiotensin II; Animals; Blood Pressure; Cardiomyopathies; Enzyme Inhibi

2000
Aldosterone: a mediator of myocardial necrosis and renal arteriopathy.
    Endocrinology, 2000, Volume: 141, Issue:10

    Topics: Adrenalectomy; Aldosterone; Angiotensin II; Animals; Blood Pressure; Cardiomyopathies; Enzyme Inhibi

2000
Aldosterone: a mediator of myocardial necrosis and renal arteriopathy.
    Endocrinology, 2000, Volume: 141, Issue:10

    Topics: Adrenalectomy; Aldosterone; Angiotensin II; Animals; Blood Pressure; Cardiomyopathies; Enzyme Inhibi

2000
Aldosterone: a mediator of myocardial necrosis and renal arteriopathy.
    Endocrinology, 2000, Volume: 141, Issue:10

    Topics: Adrenalectomy; Aldosterone; Angiotensin II; Animals; Blood Pressure; Cardiomyopathies; Enzyme Inhibi

2000
Aldosterone: a mediator of myocardial necrosis and renal arteriopathy.
    Endocrinology, 2000, Volume: 141, Issue:10

    Topics: Adrenalectomy; Aldosterone; Angiotensin II; Animals; Blood Pressure; Cardiomyopathies; Enzyme Inhibi

2000
Aldosterone: a mediator of myocardial necrosis and renal arteriopathy.
    Endocrinology, 2000, Volume: 141, Issue:10

    Topics: Adrenalectomy; Aldosterone; Angiotensin II; Animals; Blood Pressure; Cardiomyopathies; Enzyme Inhibi

2000
Aldosterone: a mediator of myocardial necrosis and renal arteriopathy.
    Endocrinology, 2000, Volume: 141, Issue:10

    Topics: Adrenalectomy; Aldosterone; Angiotensin II; Animals; Blood Pressure; Cardiomyopathies; Enzyme Inhibi

2000
Aldosterone: a mediator of myocardial necrosis and renal arteriopathy.
    Endocrinology, 2000, Volume: 141, Issue:10

    Topics: Adrenalectomy; Aldosterone; Angiotensin II; Animals; Blood Pressure; Cardiomyopathies; Enzyme Inhibi

2000
Aldosterone: a mediator of myocardial necrosis and renal arteriopathy.
    Endocrinology, 2000, Volume: 141, Issue:10

    Topics: Adrenalectomy; Aldosterone; Angiotensin II; Animals; Blood Pressure; Cardiomyopathies; Enzyme Inhibi

2000
Adrenocortical function in response to myocardial necrosis in exercise-trained rats.
    Journal of applied physiology: respiratory, environmental and exercise physiology, 1978, Volume: 44, Issue:1

    Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Aldosterone; Animals; Body Weight; Cardiomyopathies; Co

1978
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 39-1972.
    The New England journal of medicine, 1972, Sep-28, Volume: 287, Issue:13

    Topics: Adenoma; Adrenal Gland Diseases; Adrenal Gland Neoplasms; Adrenal Glands; Aldosterone; Diagnosis, Di

1972
Remission of primary hyperaldosteronism after adrenal venography.
    The New England journal of medicine, 1971, Aug-05, Volume: 285, Issue:6

    Topics: Adrenal Gland Neoplasms; Adrenal Glands; Aldosterone; Catheterization; Humans; Hyperaldosteronism; M

1971