Page last updated: 2024-09-24

3,3'-dioctadecylindocarbocyanine

Description

3,3'-dioctadecylindocarbocyanine: RN given refers to parent cpd [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

dilC18(3)(1+) : The cationic form of a C3 cyanine dye having 3,3-dimethyl-1-octadecylindoleinine units at each end. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID5706736
CHEBI ID52818
MeSH IDM0082368

Synonyms (8)

Synonym
3,3'-dioctadecylindocarbocyanine
2-[3-(3,3-dimethyl-1-octadecyl-1,3-dihydro-2h-indol-2-ylidene)prop-1-en-1-yl]-3,3-dimethyl-1-octadecyl-3h-indolium
1,1'-dotic
2-(3-(1,3-dihydro-3,3-dimethyl-1-octadecyl-2h-indol-2-ylidene)-1-propenyl)-3,3-dimethyl-1-octadecyl-3h-indolium
CHEBI:52818
dilc18(3)(1+)
1,1'-dioctadecyl-3,3,3',3'-tetramethylindocarbocyanine
Q27123626

Roles (1)

RoleDescription
fluorochromeA fluorescent dye used to stain biological specimens.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (2)

ClassDescription
Cy5 dye
indolium ion
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (656)

TimeframeStudies, This Drug (%)All Drugs %
pre-199022 (3.35)18.7374
1990's429 (65.40)18.2507
2000's133 (20.27)29.6817
2010's64 (9.76)24.3611
2020's8 (1.22)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials2 (0.29%)5.53%
Reviews6 (0.87%)6.00%
Case Studies1 (0.15%)4.05%
Observational0 (0.00%)0.25%
Other680 (98.69%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research Highlights

Safety/Toxicity (6)

ArticleYear
DiI labeling of human adipose-derived stem cells: evaluation of DNA damage, toxicity and functional impairment.
Cells, tissues, organs, Volume: 197, Issue: 5
2013
Synthetic liposomes are protective from bleomycin-induced lung toxicity.
American journal of physiology. Lung cellular and molecular physiology, Volume: 301, Issue: 2
2011
Long-term efficacy and safety of human umbilical cord mesenchymal stromal cells in rotenone-induced hemiparkinsonian rats.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, Volume: 16, Issue: 11
2010
Toxicity in vital fluorescence microscopy: effect of dimethylsulfoxide, rhodamine-123, and DiI-low density lipoprotein on fibroblast growth in vitro.
In vitro cellular & developmental biology : journal of the Tissue Culture Association, Volume: 27A, Issue: 8
1991
Toxicity of "DiI" for embryonic rat motoneurons and sensory neurons in vitro.
Life sciences, Volume: 49, Issue: 26
1991
Direct visualisation and quantification of cellular cytotoxicity using two colour flourescence.
Journal of immunological methods, Nov-25, Volume: 156, Issue: 1
1992
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Pharmacokinetics (1)

ArticleYear
Delayed increase of cell volume of single pyramidal cells in live rat hippocampal slices upon kainate application.
Neuroscience letters, May-19, Volume: 191, Issue: 1-2
1995
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Dosage (3)

ArticleYear
Alcohol exposure during the first two trimesters-equivalent alters the development of corpus callosum projection neurons in the rat.
Alcohol (Fayetteville, N.Y.), Volume: 42, Issue: 4
2008
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Interactions (1)

ArticleYear
DiI tracing in combination with immunocytochemistry for analysis of connectivities and chemoarchitectonics of specific neural systems in a teleost, the Atlantic salmon.
Journal of neuroscience methods, Volume: 42, Issue: 1-2
1992
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]