fomepizole has been researched along with Necrosis in 6 studies
Fomepizole: A pyrazole and competitive inhibitor of ALCOHOL DEHYDROGENASE that is used for the treatment of poisoning by ETHYLENE GLYCOL or METHANOL.
fomepizole : A member of the class of pyrazoles that is 1H-pyrazole substituted by a methyl group at position 4.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| "When administered four hours after a toxic dose of acetaminophen, 4-methylpyrazole significantly inhibits hepatotoxicity in the rat, as reflected by lower levels of serum transaminases and lesser degrees of hepatic necrosis." | 3.69 | 4-Methylpyrazole blocks acetaminophen hepatotoxicity in the rat. ( Baevsky, RH; Brennan, RJ; DelVecchio, JA; Lefevre, R; Mankes, RF; Raccio-Robak, N; Zink, BJ, 1994) |
| "The basis for susceptibility to halothane-induced liver necrosis in guinea-pigs was examined." | 3.69 | Halothane-induced liver injury in guinea-pigs: importance of cytochrome P450 enzyme activity and hepatic blood flow. ( Farrell, GC; Field, J; Frost, L; Mahoney, J; Tapner, M; Weltman, M, 1996) |
| "Necrosis was analyzed by quantification of lactate dehydrogenase (LDH) release into culture medium." | 1.31 | Cytotoxicity of millimolar concentrations of ethanol on HepG2 human tumor cell line compared to normal rat hepatocytes in vitro. ( Castañeda, F; Kinne, RK, 2000) |
| " In conclusion, the administration of 4-MP and/or NAC after 4 h of administering toxic dose of acetaminophen, inhibits hepatotoxicity in rats." | 1.31 | Comparison of the therapeutic efficacy of 4-methylpyrazole and N-acetylcysteine on acetaminophen (paracetamol) hepatotoxicity in rats. ( Acar, HV; Cankir, Z; Cermik, H; Cinan, U; Danaci, M; Küçükardali, Y; Nalbant, S; Ozkan, S; Top, C, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Akakpo, JY | 1 |
| Jaeschke, MW | 1 |
| Etemadi, Y | 1 |
| Artigues, A | 1 |
| Toerber, S | 1 |
| Olivos, H | 1 |
| Shrestha, B | 1 |
| Midey, A | 1 |
| Jaeschke, H | 1 |
| Ramachandran, A | 1 |
| Huang, W | 1 |
| Booth, DM | 1 |
| Cane, MC | 1 |
| Chvanov, M | 1 |
| Javed, MA | 1 |
| Elliott, VL | 1 |
| Armstrong, JA | 1 |
| Dingsdale, H | 1 |
| Cash, N | 1 |
| Li, Y | 1 |
| Greenhalf, W | 1 |
| Mukherjee, R | 1 |
| Kaphalia, BS | 1 |
| Jaffar, M | 1 |
| Petersen, OH | 1 |
| Tepikin, AV | 1 |
| Sutton, R | 1 |
| Criddle, DN | 1 |
| Brennan, RJ | 1 |
| Mankes, RF | 1 |
| Lefevre, R | 1 |
| Raccio-Robak, N | 1 |
| Baevsky, RH | 1 |
| DelVecchio, JA | 1 |
| Zink, BJ | 1 |
| Farrell, GC | 1 |
| Frost, L | 1 |
| Tapner, M | 1 |
| Field, J | 1 |
| Weltman, M | 1 |
| Mahoney, J | 1 |
| Castañeda, F | 1 |
| Kinne, RK | 1 |
| Küçükardali, Y | 1 |
| Cinan, U | 1 |
| Acar, HV | 1 |
| Ozkan, S | 1 |
| Top, C | 1 |
| Nalbant, S | 1 |
| Cermik, H | 1 |
| Cankir, Z | 1 |
| Danaci, M | 1 |
6 other studies available for fomepizole and Necrosis
| Article | Year |
|---|---|
Desorption Electrospray Ionization Mass Spectrometry Imaging Allows Spatial Localization of Changes in Acetaminophen Metabolism in the Liver after Intervention with 4-Methylpyrazole.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Fomepizole; Humans; Liver; Mice; Mic | 2022 |
Fatty acid ethyl ester synthase inhibition ameliorates ethanol-induced Ca2+-dependent mitochondrial dysfunction and acute pancreatitis.
Topics: Acinar Cells; Acyltransferases; Animals; Apoptosis; Calcium; Calcium Signaling; Carboxylesterase; Ce | 2014 |
4-Methylpyrazole blocks acetaminophen hepatotoxicity in the rat.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Dose-Response Relationshi | 1994 |
Halothane-induced liver injury in guinea-pigs: importance of cytochrome P450 enzyme activity and hepatic blood flow.
Topics: Animals; Arteries; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Fomepizole; Genetic Pred | 1996 |
Cytotoxicity of millimolar concentrations of ethanol on HepG2 human tumor cell line compared to normal rat hepatocytes in vitro.
Topics: Alcohol Dehydrogenase; Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Division; Cells, Cultured | 2000 |
Comparison of the therapeutic efficacy of 4-methylpyrazole and N-acetylcysteine on acetaminophen (paracetamol) hepatotoxicity in rats.
Topics: Acetaminophen; Acetylcysteine; Alcohol Dehydrogenase; Analgesics, Non-Narcotic; Animals; Antidotes; | 2002 |