Page last updated: 2024-08-07 16:18:45
Beta-3 adrenergic receptor
A beta-3 adrenergic receptor that is encoded in the genome of rat. [OMA:P26255, PRO:DNx]
Synonyms
Beta-3 adrenoreceptor;
Beta-3 adrenoceptor
Research
Bioassay Publications (19)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 8 (42.11) | 18.7374 |
| 1990's | 7 (36.84) | 18.2507 |
| 2000's | 3 (15.79) | 29.6817 |
| 2010's | 1 (5.26) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (26)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| n(8)-bromoacetyl-n(1)-3'-(4-indolyloxy)-2'-hydroxypropyl-1,8-diamino-4-menthane | Rattus norvegicus (Norway rat) | Ki | 0.0009 | 2 | 2 |
| buspirone | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 1 |
| haloperidol | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| isoproterenol | Rattus norvegicus (Norway rat) | IC50 | 0.2125 | 2 | 2 |
| ondansetron | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| pindobind | Rattus norvegicus (Norway rat) | Ki | 0.0135 | 2 | 2 |
| propranolol | Rattus norvegicus (Norway rat) | IC50 | 0.0120 | 2 | 3 |
| propranolol | Rattus norvegicus (Norway rat) | Ki | 1.6000 | 1 | 1 |
| tetrahydropapaverine | Rattus norvegicus (Norway rat) | Ki | 1.0000 | 1 | 2 |
| tetrahydropapaveroline | Rattus norvegicus (Norway rat) | Ki | 0.3000 | 1 | 2 |
| flavodilol | Rattus norvegicus (Norway rat) | Ki | 0.0040 | 1 | 1 |
| 1-(2-allylphenoxy)-3-((8-bromoacetylamino-4-menthane-1-yl)amino)-1-propanol | Rattus norvegicus (Norway rat) | Ki | 0.2585 | 2 | 2 |
| 4-(3-chloroanilino)quinazoline | Rattus norvegicus (Norway rat) | IC50 | 0.0110 | 1 | 1 |
| (R)-norlaudanosoline | Rattus norvegicus (Norway rat) | Ki | 30.0000 | 1 | 2 |
| cilastatin | Rattus norvegicus (Norway rat) | Ki | 0.1700 | 1 | 3 |
| cilansetron | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| vn2222 | Rattus norvegicus (Norway rat) | Ki | 0.7500 | 1 | 1 |
| 1-(2-allylphenoxy)-3-((1-bromoacetylamino-4-menthane-8-yl)amino)-2-propanol | Rattus norvegicus (Norway rat) | Ki | 0.0255 | 2 | 2 |
| clozapine | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| norepinephrine, (+,-)-isomer | Rattus norvegicus (Norway rat) | EC50 | 1.9000 | 2 | 2 |
| n(8)-bromoacetyl-n(1)-3'-(4-indolyloxy)-2'-hydroxypropyl-1,8-diamino-4-menthane | Rattus norvegicus (Norway rat) | Kd | 0.0019 | 2 | 3 |
| 6-fluoronorepinephrine | Rattus norvegicus (Norway rat) | EC50 | 10.0000 | 1 | 1 |
| isoproterenol | Rattus norvegicus (Norway rat) | EC50 | 0.0470 | 2 | 2 |
| pindobind | Rattus norvegicus (Norway rat) | Kd | 0.0017 | 2 | 2 |
| 4-[(1S)-1-hydroxy-2-(propan-2-ylamino)ethyl]benzene-1,2-diol | Rattus norvegicus (Norway rat) | EC50 | 63.0000 | 1 | 1 |
| du-21220 | Rattus norvegicus (Norway rat) | EC50 | 0.1906 | 1 | 1 |
| 1-(2-allylphenoxy)-3-((8-bromoacetylamino-4-menthane-1-yl)amino)-1-propanol | Rattus norvegicus (Norway rat) | Kd | 0.0516 | 4 | 9 |
| 3-fluoronorepinephrine | Rattus norvegicus (Norway rat) | EC50 | 0.0630 | 1 | 1 |
| cl 316243 | Rattus norvegicus (Norway rat) | EC50 | 0.0251 | 1 | 1 |
| brl 37344 | Rattus norvegicus (Norway rat) | EC50 | 0.0011 | 2 | 2 |
| 1-(2-allylphenoxy)-3-((1-bromoacetylamino-4-menthane-8-yl)amino)-2-propanol | Rattus norvegicus (Norway rat) | Kd | 0.1278 | 4 | 7 |
| 6-fluoronorepinephrine monohydrochloride, (+-)-isomer | Rattus norvegicus (Norway rat) | EC50 | 51.5000 | 2 | 2 |