Proteins > Peroxisome proliferator-activated receptor delta
Page last updated: 2024-08-07 16:34:25
Peroxisome proliferator-activated receptor delta
A peroxisome proliferator-activated receptor delta that is encoded in the genome of mouse. [OMA:P35396, PRO:DNx]
Synonyms
PPAR-delta;
Nuclear hormone receptor 1;
NUC1;
Nuclear receptor subfamily 1 group C member 2;
Peroxisome proliferator-activated receptor beta;
PPAR-beta
Research
Bioassay Publications (14)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (7.14) | 18.2507 |
| 2000's | 6 (42.86) | 29.6817 |
| 2010's | 6 (42.86) | 24.3611 |
| 2020's | 1 (7.14) | 2.80 |
Compounds (12)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| gsk0660 | Mus musculus (house mouse) | IC50 | 0.1740 | 2 | 2 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| gw 2433 | Mus musculus (house mouse) | EC50 | 0.4100 | 1 | 1 |
| bezafibrate | Mus musculus (house mouse) | EC50 | 110.0000 | 2 | 2 |
| telmisartan | Mus musculus (house mouse) | EC50 | 10.0000 | 1 | 1 |
| mk 767 | Mus musculus (house mouse) | EC50 | 7.2000 | 1 | 1 |
| gw 7647 | Mus musculus (house mouse) | EC50 | 2.9000 | 1 | 1 |
| l-165041 | Mus musculus (house mouse) | EC50 | 3.8000 | 1 | 1 |
| gw 501516 | Mus musculus (house mouse) | EC50 | 0.0594 | 5 | 5 |
| gw 9578 | Mus musculus (house mouse) | EC50 | 2.4000 | 3 | 3 |
| l 796449 | Mus musculus (house mouse) | EC50 | 0.0230 | 1 | 1 |
| gw0742 | Mus musculus (house mouse) | EC50 | 0.0179 | 2 | 2 |
| gw 590735 | Mus musculus (house mouse) | EC50 | 1.3500 | 2 | 2 |
The PPARs: from orphan receptors to drug discovery.Journal of medicinal chemistry, , Feb-24, Volume: 43, Issue:4, 2000
A ureido-thioisobutyric acid (GW9578) is a subtype-selective PPARalpha agonist with potent lipid-lowering activity.Journal of medicinal chemistry, , Sep-23, Volume: 42, Issue:19, 1999
Discovery and structure-based design of a new series of potent and selective PPARδ agonists utilizing a virtual screening method.Bioorganic & medicinal chemistry letters, , 03-01, Volume: 59, 2022
Highly selective peroxisome proliferator-activated receptor δ (PPARδ) modulator demonstrates improved safety profile compared to GW501516.Bioorganic & medicinal chemistry letters, , 02-01, Volume: 28, Issue:3, 2018
Novel bisaryl substituted thiazoles and oxazoles as highly potent and selective peroxisome proliferator-activated receptor delta agonists.Journal of medicinal chemistry, , Jan-14, Volume: 53, Issue:1, 2010
Identification and synthesis of a novel selective partial PPARdelta agonist with full efficacy on lipid metabolism in vitro and in vivo.Journal of medicinal chemistry, , Apr-05, Volume: 50, Issue:7, 2007
Novel selective small molecule agonists for peroxisome proliferator-activated receptor delta (PPARdelta)--synthesis and biological activity.Bioorganic & medicinal chemistry letters, , May-05, Volume: 13, Issue:9, 2003
Glycine amides as PPARalpha agonists.Bioorganic & medicinal chemistry letters, , Jun-01, Volume: 20, Issue:11, 2010
The PPARs: from orphan receptors to drug discovery.Journal of medicinal chemistry, , Feb-24, Volume: 43, Issue:4, 2000
A ureido-thioisobutyric acid (GW9578) is a subtype-selective PPARalpha agonist with potent lipid-lowering activity.Journal of medicinal chemistry, , Sep-23, Volume: 42, Issue:19, 1999
Selective peroxisome proliferator-activated receptor δ isosteric selenium agonists as potent anti-atherogenic agents in vivo.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 20, Issue:24, 2010
Novel selective small molecule agonists for peroxisome proliferator-activated receptor delta (PPARdelta)--synthesis and biological activity.Bioorganic & medicinal chemistry letters, , May-05, Volume: 13, Issue:9, 2003
Design, synthesis and evaluation of trifluoromethane sulfonamide derivatives as new potent and selective peroxisome proliferator-activated receptor alpha agonists.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 18, Issue:2, 2008
Substituted 2-[(4-aminomethyl)phenoxy]-2-methylpropionic acid PPARalpha agonists. 1. Discovery of a novel series of potent HDLc raising agents.Journal of medicinal chemistry, , Feb-22, Volume: 50, Issue:4, 2007