An aldo-keto reductase family 1 member C4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P17516]
EC 1.1.1.-;
EC 1.1.1.209;
EC 1.1.1.210;
EC 1.1.1.51;
EC 1.1.1.53;
EC 1.1.1.62;
3-alpha-hydroxysteroid dehydrogenase type I;
3-alpha-HSD1;
1.1.1.357;
3alpha-hydroxysteroid 3-dehydrogenase;
Chlordecone reductase;
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| flufenamic acid | Homo sapiens (human) | IC50 | 100.0000 | 2 | 2 |
| flurbiprofen | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| indomethacin | Homo sapiens (human) | IC50 | 77.0000 | 2 | 2 |
| meclofenamic acid | Homo sapiens (human) | IC50 | 100.0000 | 2 | 2 |
| mefenamic acid | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| 3,5-dichlorosalicylic acid | Homo sapiens (human) | Ki | 16.1432 | 2 | 9 |
| 3,5-dibromosalicylic acid | Homo sapiens (human) | Ki | 45.7000 | 1 | 1 |
| dexibuprofen | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| octyl gallate | Homo sapiens (human) | IC50 | 4.0400 | 1 | 1 |
| naproxen | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| jasmonic acid | Homo sapiens (human) | Ki | 37.0000 | 1 | 1 |
| caffeic acid phenethyl ester | Homo sapiens (human) | IC50 | 5.2750 | 2 | 2 |
This protein enables 16 target(s):
| Target | Category | Definition |
|---|---|---|
| retinal dehydrogenase activity | molecular function | Catalysis of the reaction: retinal + NAD+ + H2O = retinoate + NADH. Acts on both 11-trans and 13-cis forms of retinal. [EC:1.2.1.36] |
| aldo-keto reductase (NADPH) activity | molecular function | Catalysis of the reaction: an alcohol + NADP+ = an aldehyde or a ketone + NADPH + H+. [GOC:ai] |
| estradiol 17-beta-dehydrogenase [NAD(P)] activity | molecular function | Catalysis of the reaction: estradiol-17-beta + NAD(P)+ = estrone + NAD(P)H + H+. The activity can use NAD+ or NADP+ as the acceptor. [EC:1.1.1.62] |
| electron transfer activity | molecular function | A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. [Wikipedia:Electron_transfer] |
| bile acid transmembrane transporter activity | molecular function | Enables the transfer of bile acid from one side of a membrane to the other. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine. [GOC:ai] |
| oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor | molecular function | Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule. [GOC:ai] |
| dihydrotestosterone 17-beta-dehydrogenase activity | molecular function | Catalysis of the reaction: 5alpha-dihydrotestosterone + NAD+ = 5alpha-androstane-3,17-dione + NADH. [GOC:ecd, http://www.brenda-enzymes.org/php/result_flat.php4?ecno=1.1.1.63, PMID:4152755] |
| androsterone dehydrogenase activity | molecular function | Catalysis of the reaction: NAD(P)+ + androsterone = NAD(P)H + H+ + 5-alpha-androstane-3,17-dione. [EC:1.1.1.209, MetaCyc:1.1.1.209-RXN] |
| 5alpha-androstane-3beta,17beta-diol dehydrogenase activity | molecular function | Catalysis of the reaction: 5alpha-androstane-3beta,17beta-diol + NADP+ = 17beta-hydroxy-5alpha-androstan-3-one + H+ + NADPH. [EC:1.1.1.210, RHEA:16297] |
| testosterone dehydrogenase (NAD+) activity | molecular function | Catalysis of the reaction: testosterone + NAD+ = androst-4-ene-3,17-dione + NADH. [EC:1.1.1.239] |
| androstan-3-alpha,17-beta-diol dehydrogenase activity | molecular function | Catalysis of the reaction: NAD+ + androstan-3-alpha,17-beta-diol = 17-beta-hydroxyandrostan-3-one + NADH + H+. [EC:1.1.1.53, MetaCyc:1.1.1.53-RXN] |
| testosterone 17-beta-dehydrogenase (NADP+) activity | molecular function | Catalysis of the reaction: NADP+ + testosterone = NADPH + H+ + androst-4-ene-3,17-dione. [EC:1.1.1.64, MetaCyc:1.1.1.64-RXN] |
| chlordecone reductase activity | molecular function | Catalysis of the reaction: chlordecone alcohol + NADP+ = chlordecone + H+ + NADPH. [EC:1.1.1.225, RHEA:14401] |
| aldose reductase (NADPH) activity | molecular function | Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+. [EC:1.1.1.21] |
| ketosteroid monooxygenase activity | molecular function | Catalysis of the reaction: O2 + NADPH + progesterone = H2O + NADP+ + testosterone acetate. [EC:1.14.13.54, MetaCyc:1.14.13.54-RXN] |
| bile acid binding | molecular function | Binding to a bile acid, a steroid carboxylic acids occurring in bile. [GOC:rph] |
This protein is located in 3 target(s):
| Target | Category | Definition |
|---|---|---|
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| extracellular exosome | cellular component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
This protein is involved in 10 target(s):
| Target | Category | Definition |
|---|---|---|
| retinoid metabolic process | biological process | The chemical reactions and pathways involving retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity. [ISBN:0198506732] |
| bile acid biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile. [GOC:go_curators] |
| steroid metabolic process | biological process | The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. [ISBN:0198547684] |
| androgen metabolic process | biological process | The chemical reactions and pathways involving androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics. [ISBN:0198506732] |
| bile acid and bile salt transport | biological process | The directed movement of bile acid and bile salts into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:dph, GOC:krc, PMID:12663868, PMID:14699511] |
| daunorubicin metabolic process | biological process | The chemical reactions and pathways involving daunorubicin, a chemotherapeutic of the anthracycline family that is given as a treatment for some types of cancer. [PMID:20837989] |
| doxorubicin metabolic process | biological process | The chemical reactions and pathways involving doxorubicin, an anthracycline antibiotic, used in cancer chemotherapy. [PMID:10200167] |
| cellular response to jasmonic acid stimulus | biological process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a jasmonic acid stimulus. [GOC:mah] |
| prostaglandin metabolic process | biological process | The chemical reactions and pathways involving prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities. [ISBN:0198506732] |
| progesterone metabolic process | biological process | The chemical reactions and pathways involving progesterone, a steroid hormone produced in the ovary which prepares and maintains the uterus for pregnancy. Also found in plants. [GOC:jl, http://www.cogsci.princeton.edu/] |